TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 371.313 | Formula: C19H12F3N3O2
H donors: 1 H acceptors: 2 LogP: 3.74 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)n1c2cccc(c2cc2c1nc(=O)[nH]c2=O)C(F)(F)F
InChi: 1S/C19H12F3N3O2/c1-10-5-7-11(8-6-10)25-15-4-2-3-14(19(20,21)22)12(15)9-13-16(25)23-18(27)24-17(13)26/h2-9H,1H3,(H,24,26,27)
InChiKey: HTMQMAGZNFLTMQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	Heat shock protein 83, putative	0.0026	0.0369	0.1545
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0023	0.03	0.1848
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0309	0.0807
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0173	0.0047
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0183	0.0057
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0309	0.1196
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0183	0.1073
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0045	0.0884	0.0767
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0021	0.0234	0.0981
Trypanosoma brucei	brix domain containing protein, putative	0.0062	0.1374	0.5512
Trypanosoma brucei	AMP deaminase, putative	0.0099	0.2389	1
Echinococcus multilocularis	p2X purinoceptor 4	0.0343	0.9123	0.9112
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0183	0.0057
Schistosoma mansoni	z-protein (S1r protein)	0.0019	0.0183	0.0063
Plasmodium falciparum	heat shock protein 90, putative	0.0017	0.0126	0.0445
Leishmania major	AMP deaminase, putative	0.0099	0.2389	1
Brugia malayi	regulator of G-protein signaling rgs-7	0.0019	0.0183	0.0251
Trypanosoma cruzi	heat shock protein 85, putative	0.0026	0.0369	0.1545
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0021	0.0234	0.0981
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Echinococcus multilocularis	expressed protein	0.0375	1	1
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0068	0.1532	0.6213
Trypanosoma brucei	heat shock protein, putative	0.0026	0.0369	0.1073
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.003	0.0475	0.2219
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0309	0.0807
Trypanosoma cruzi	heat shock protein 90, putative	0.0026	0.0369	0.1545
Chlamydia trachomatis	glyceraldehyde-3-phosphate dehydrogenase	0.0068	0.1532	1
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0068	0.1532	0.6213
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0309	0.1196
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0045	0.0883	0.3695
Brugia malayi	A-kinase anchor protein 10, precursor	0.0019	0.0183	0.0251
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0173	0.1591
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0173	0.0724
Leishmania major	AMP deaminase, putative,amp deaminase-like protein	0.0099	0.2389	1
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.0045	0.0883	0.5222
Echinococcus granulosus	heat shock protein 90	0.0026	0.0369	0.0246
Loa Loa (eye worm)	RGS-3 protein	0.0019	0.0183	0.0251
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0173	0.0218
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0019	0.0183	0.0057
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0309	0.1196
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0143	0.0748
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0309	0.0807
Giardia lamblia	Peter pan protein	0.0062	0.1374	0.8833
Trypanosoma brucei	heat shock protein, putative	0.0026	0.0369	0.1073
Brugia malayi	adenosine monophosphate deaminase	0.0099	0.2389	1
Echinococcus granulosus	p2X purinoceptor 4	0.0343	0.9123	0.9112
Schistosoma mansoni	peter pan-related	0.0062	0.1374	0.1386
Trichomonas vaginalis	ssf, putative	0.0062	0.1374	0.895
Plasmodium falciparum	glyceraldehyde-3-phosphate dehydrogenase	0.0068	0.1532	0.6382
Plasmodium falciparum	heat shock protein 90	0.0026	0.0369	0.1471
Schistosoma mansoni	endoplasmin	0.0026	0.0369	0.027
Schistosoma mansoni	heat shock protein	0.0026	0.0369	0.027
Mycobacterium ulcerans	heat shock protein 90	0.003	0.0475	0.2389
Schistosoma mansoni	heat shock protein	0.0026	0.0369	0.027
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0173	0.0206
Schistosoma mansoni	AMP deaminase	0.0099	0.2389	0.2515
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0309	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0183	0.0251
Toxoplasma gondii	exonuclease III APE	0.0019	0.0173	0.0139
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0026	0.0369	0.1443
Trypanosoma cruzi	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0045	0.0883	0.3695
Trypanosoma cruzi	AMP deaminase, putative	0.0099	0.2389	1
Trypanosoma brucei	AMP deaminase, putative	0.0099	0.2389	1
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0183	0.0057
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Toxoplasma gondii	heat shock protein 90, putative	0.0026	0.0369	0.0721
Trypanosoma brucei	heat shock protein, putative	0.0026	0.0369	0.1073
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.0045	0.0884	0.3347
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0173	0.0206
Trypanosoma cruzi	heat shock protein 90, putative	0.0026	0.0369	0.1545
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, cytosolic	0.0068	0.1532	0.6213
Leishmania major	adenosine monophosphate deaminase, putative,AMP deaminase, putative	0.0099	0.2389	1
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0019	0.0183	0.0057
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0068	0.1532	0.6213
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0143	0.0073
Onchocerca volvulus	Peter pan protein homolog	0.0062	0.1374	0.5512
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0183	0.0057
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0309	0.5379
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0183	0.0251
Schistosoma mansoni	endoplasmin	0.0026	0.0369	0.027
Schistosoma mansoni	ap endonuclease	0.0019	0.0173	0.0052
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0309	0.0807
Trypanosoma cruzi	AMP deaminase, putative	0.0099	0.2389	1
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0068	0.1532	0.6213
Trypanosoma brucei	heat shock protein, putative	0.0026	0.0369	0.1073
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0309	0.1196
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0068	0.1532	0.1563
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0068	0.1532	0.6413
Brugia malayi	PXA domain containing protein	0.0019	0.0183	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0884	0.3347
Plasmodium vivax	adenosine/AMP deaminase, putative	0.0099	0.2389	1
Trypanosoma brucei	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0045	0.0883	0.3343
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.0047	0.095	0.3638
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0068	0.1532	0.6413
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0173	0.0724
Brugia malayi	heat shock protein 90	0.0026	0.0369	0.1073
Toxoplasma gondii	5'-nucleotidase, C-terminal domain-containing protein	0.0139	0.3495	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0143	0.0073
Loa Loa (eye worm)	glyceraldehyde-3-phosphate dehydrogenase	0.0047	0.095	0.3638
Trichomonas vaginalis	heat shock protein, putative	0.003	0.0475	0.3003
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0068	0.1532	0.1563
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0183	0.0251
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0068	0.1532	0.1424
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0019	0.0183	0.0251
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0183	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0183	0.0251
Schistosoma mansoni	P2X receptor subunit	0.0343	0.9123	1
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0068	0.1532	0.1424
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0309	0.0446
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0309	0.1196
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0068	0.1532	1
Echinococcus granulosus	peter pan	0.0062	0.1374	0.1263
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0173	0.0206
Schistosoma mansoni	P2X receptor subunit	0.0343	0.9123	1
Schistosoma mansoni	23-cyclic-nucleotide 2-phosphodiesterase	0.0139	0.3495	0.3744
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0019	0.0183	0.0251
Trypanosoma brucei	heat shock protein 90, putative	0.0026	0.0369	0.1073
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0173	0.1007
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0021	0.0234	0.0981
Trypanosoma brucei	heat shock protein, putative	0.0026	0.0369	0.1073
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0183	0.1073
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.003	0.0475	1
Plasmodium vivax	hypothetical protein, conserved	0.0062	0.1374	0.5512
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0045	0.0884	0.5709
Toxoplasma gondii	brix domain-containing protein	0.0062	0.1374	0.3702
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0068	0.1532	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2389	1
Schistosoma mansoni	P2X receptor subunit	0.0204	0.5297	0.5747
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0021	0.0234	0.0981
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0068	0.1532	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0309	0.0807
Trypanosoma cruzi	peter pan protein, putative	0.0062	0.1374	0.5749
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0068	0.1532	1
Entamoeba histolytica	brix domain containing protein	0.0062	0.1374	0.5512
Echinococcus multilocularis	zinc finger protein 598	0.0062	0.1363	0.1252
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0183	0.0063
Brugia malayi	glyceraldehyde 3-phosphate dehydrogenase	0.0021	0.0234	0.0477
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0309	0.0446
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative	0.0021	0.0234	0.0981
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0183	0.1073
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0183	0.0063
Giardia lamblia	Glyceraldehyde 3-phosphate dehydrogenase	0.0068	0.1532	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0183	0.0057
Plasmodium falciparum	AMP deaminase, putative	0.0099	0.2389	1
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0183	0.0251
Brugia malayi	hypothetical protein	0.0019	0.0183	0.0251
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0183	0.0063
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH2	0.0068	0.1532	0.4174
Onchocerca volvulus	AMP deaminase 2 homolog	0.0099	0.2389	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0309	0.0807
Echinococcus multilocularis	p2X purinoceptor 4	0.0343	0.9123	0.9112
Brugia malayi	PXA domain containing protein	0.0019	0.0183	0.0251
Toxoplasma gondii	glyceraldehyde-3-phosphate dehydrogenase GAPDH1	0.0068	0.1532	0.4174
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0183	0.0057
Toxoplasma gondii	5'-nucleotidase, C-terminal domain-containing protein	0.0057	0.1234	0.3287
Loa Loa (eye worm)	AMP deaminase	0.0099	0.2389	1
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0183	0.1073
Loa Loa (eye worm)	glyceraldehyde 3-phosphate dehydrogenase	0.0045	0.0884	0.3347
Trypanosoma cruzi	adenosine monophosphate deaminase-like protein, putative	0.0099	0.2389	1
Echinococcus granulosus	glyceraldehyde 3 phosphate dehydrogenase	0.0045	0.0884	0.0767
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0183	0.1073
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0309	0.0807
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0068	0.1532	0.1563
Echinococcus granulosus	heat shock protein	0.0026	0.0369	0.0246
Plasmodium vivax	heat shock protein 86, putative	0.0026	0.0369	0.1073
Trypanosoma cruzi	AMP deaminase, putative	0.0099	0.2389	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0309	0.5379
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0173	0.0206
Trypanosoma brucei	heat shock protein 90, putative	0.0026	0.0369	0.1073
Trypanosoma brucei	heat shock protein, putative	0.0026	0.0369	0.1073
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0143	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0143	0.0073
Trypanosoma brucei	adenosine monophosphate deaminase, putative	0.0099	0.2389	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0143	0.0073
Schistosoma mansoni	P2X receptor subunit	0.0204	0.5297	0.5747
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Trypanosoma cruzi	heat shock protein 85, putative	0.0026	0.0369	0.1545
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0019	0.0183	0.0251
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0173	0.1007
Echinococcus multilocularis	p2X purinoceptor 4	0.0343	0.9123	0.9112
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0183	0.0251
Echinococcus granulosus	p2X purinoceptor 4	0.0343	0.9123	0.9112
Toxoplasma gondii	AMP deaminase	0.0099	0.2389	0.6717
Giardia lamblia	Grp94/Hsp90	0.003	0.0475	0.2219
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0068	0.1532	0.6213
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0019	0.0183	0.0057
Entamoeba histolytica	heat shock protein 90, putative	0.0026	0.0369	0.1073
Trypanosoma cruzi	adenosine monophosphate deaminase, putative	0.0099	0.2389	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0143	0.0073
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0068	0.1532	0.6413
Schistosoma mansoni	ap endonuclease	0.0019	0.0173	0.0052
Schistosoma mansoni	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.0068	0.1532	0.1563
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0183	0.0057
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0068	0.1532	0.6413
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0019	0.0183	0.0057
Brugia malayi	Glyceraldehyde 3-phosphate dehydrogenase	0.0023	0.03	0.0768
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0309	0.1196
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0068	0.1532	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0026	0.0369	0.1545
Entamoeba histolytica	hypothetical protein	0.0019	0.0183	0.0251
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0183	0.0063
Echinococcus multilocularis	peter pan	0.0062	0.1374	0.1263
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Onchocerca volvulus		0.0024	0.0309	0.0807
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0369	0.2305
Leishmania major	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0068	0.1532	0.6213
Mycobacterium tuberculosis	Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH)	0.0024	0.0301	0.5164
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0173	0.0206
Echinococcus multilocularis	heat shock protein	0.0026	0.0369	0.0246
Echinococcus granulosus	AMP deaminase 2	0.0099	0.2389	0.2292
Echinococcus granulosus	Regulator of G protein signaling 20	0.0019	0.0183	0.0057
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0183	0.0057
Entamoeba histolytica	AMP deaminase, putative	0.0099	0.2389	1
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0068	0.1532	1
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0019	0.0183	0.0063
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0019	0.0183	0.1073
Trypanosoma cruzi	AMP deaminase, putative	0.0099	0.2389	1
Trypanosoma brucei	glyceraldehyde 3-phosphate dehydrogenase, glycosomal	0.0068	0.1532	0.6213
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Brugia malayi	Endoplasmin precursor	0.0026	0.0369	0.1073
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0183	0.0063
Toxoplasma gondii	heat shock protein HSP90	0.0026	0.0369	0.0721
Plasmodium vivax	endoplasmin, putative	0.0026	0.0369	0.1073
Echinococcus multilocularis	heat shock protein 90	0.0026	0.0369	0.0246
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0183	0.0063
Loa Loa (eye worm)	PXA domain-containing protein	0.0019	0.0183	0.0251
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0183	0.0251
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0026	0.0369	0.1443
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0143	0.0073
Entamoeba histolytica	hypothetical protein	0.0019	0.0183	0.0251
Trichomonas vaginalis	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0045	0.0884	0.5709
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0309	0.0807
Leishmania major	glyceraldehyde-3-phosphate dehydrogenase-like protein	0.0045	0.0883	0.3343
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0183	0.0063
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0309	0.1196
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0183	0.0057
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0173	0.0642
Leishmania major	peter pan protein, putative	0.0062	0.1374	0.5512
Echinococcus granulosus	heat shock protein 90	0.0026	0.0369	0.0246
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, putative	0.0068	0.1532	0.6413
Plasmodium vivax	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0068	0.1532	0.6213
Treponema pallidum	5'-nucleotidase (ushA)	0.0139	0.3495	1
Echinococcus multilocularis	AMP deaminase 2	0.0099	0.2389	0.2292
Treponema pallidum	glyceraldehyde 3-phosphate dehydrogenase (gap)	0.0068	0.1532	0.4092
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0173	0.0047
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.003	0.0475	0.1539
Brugia malayi	hypothetical protein	0.0019	0.0183	0.0251
Brugia malayi	Brix domain containing protein	0.0062	0.1374	0.5512
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0026	0.0369	0.0246
Trypanosoma cruzi	AMP deaminase, putative	0.0099	0.2389	1
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0183	0.1073
Echinococcus granulosus	endoplasmin	0.003	0.0475	0.0353
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0183	0.0063
Trypanosoma brucei	AMP deaminase, putative	0.0099	0.2389	1
Echinococcus multilocularis	glyceraldehyde 3 phosphate dehydrogenase	0.0068	0.1532	0.1424
Giardia lamblia	Hypothetical protein	0.0057	0.1223	0.7723
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0309	0.0807
Treponema pallidum	heat shock protein 90	0.003	0.0475	0.0908
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0183	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0183	0.0251
Echinococcus multilocularis	regulator of G protein signaling	0.0019	0.0183	0.0057
Echinococcus granulosus	zinc finger protein 598	0.0062	0.1363	0.1252
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0183	0.0063
Loa Loa (eye worm)	brix domain-containing protein	0.0062	0.1374	0.5512
Wolbachia endosymbiont of Brugia malayi	glyceraldehyde-3-phosphate dehydrogenase, GapA	0.0068	0.1532	1
Trypanosoma brucei	heat shock protein, putative	0.0026	0.0369	0.1073
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0183	0.0063
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0369	0.2305
Schistosoma mansoni	peter pan-related	0.0062	0.1374	0.1386
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.0183	0.0251
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0068	0.1532	0.6413
Echinococcus multilocularis	endoplasmin	0.003	0.0475	0.0353
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0183	0.0057
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Trypanosoma cruzi	glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative	0.0068	0.1532	0.6413
Entamoeba histolytica	heat shock protein 90, putative	0.0026	0.0369	0.1073
Entamoeba histolytica	glyceraldehyde-3-phosphate dehydrogenase, putative	0.0068	0.1532	0.6213
Trypanosoma cruzi	peter pan protein, putative	0.0062	0.1374	0.5749
Trypanosoma cruzi	heat shock protein, putative	0.0017	0.0126	0.0529
Plasmodium falciparum	BRIX domain, putative	0.0062	0.1374	0.5712
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0309	0.0807
Echinococcus multilocularis	heat shock protein 90	0.0026	0.0369	0.0246
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.003	0.0475	1
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0183	0.0057
Trypanosoma brucei	Heat shock protein 83, putative	0.0026	0.0369	0.1073
Loa Loa (eye worm)	endoplasmin	0.0026	0.0369	0.1073
Loa Loa (eye worm)	heat shock protein 90	0.0026	0.0369	0.1073
Entamoeba histolytica	AMP deaminase, putative	0.0099	0.2389	1
Leishmania major	AMP deaminase, putative,adenosine monophosphate deaminase-like protein	0.0099	0.2389	1
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Leishmania major	heat shock protein 83-1	0.0026	0.0369	0.1073
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0019	0.0183	0.0251
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0309	0.1196
Trichomonas vaginalis	heat shock protein, putative	0.003	0.0475	0.3003
Entamoeba histolytica	hypothetical protein	0.0019	0.0183	0.0251
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0183	0.0063
Trypanosoma brucei	heat shock protein, putative	0.0026	0.0369	0.1073
Mycobacterium ulcerans	glyceraldehyde 3-phosphate dehydrogenase Gap	0.0068	0.1532	1
Echinococcus granulosus	p2X purinoceptor 4	0.0343	0.9123	0.9112
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0309	0.0807
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0019	0.0183	0.0057
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0173	0.0206
Schistosoma mansoni	23-cyclic-nucleotide 2-phosphodiesterase	0.0139	0.3484	0.3732
Trypanosoma cruzi	heat shock protein 85, putative	0.0026	0.0369	0.1545

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Stabilization of p53 in RPE cells at 5 to 10 uM after 24 hrs by western blotting relative to HL198C	ChEMBL.	17064912
Activity (functional)		Stabilization of p53 in RPE cells at 1 uM after 24 hrs by western blotting	ChEMBL.	17064912
Activity (functional)	0	Stabilization of p53 in RPE cells at 1 uM after 24 hrs by western blotting	ChEMBL.	17064912
Activity (functional)	0	Stabilization of p53 in RPE cells at 5 to 10 uM after 24 hrs by western blotting relative to HL198C	ChEMBL.	17064912
Activity (functional)	0	Stabilization of p53 level in RKO cells	ChEMBL.	17064912
Activity (functional)	0	Induction of p21WAF1/CIP1 level in RPE cells	ChEMBL.	17064912
Activity (functional)	0	Induction of apoptosis in RKO cells	ChEMBL.	17064912
Activity (functional)	0	Induction of apoptosis in RKO/E6 cells	ChEMBL.	17064912
Activity (functional)	= 62 %	Cell cycle arrest in RKO cells by accumulation at G1 phase	ChEMBL.	17064912
Activity (functional)	= 62 %	Cell cycle arrest in RKO cells by accumulation at G1 phase	ChEMBL.	17064912

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL225641

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 420437