Detailed information for compound 424455

Basic information

Technical information
  • TDR Targets ID: 424455
  • Name: (2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2H-pyra zolo[3,4-c]pyridin-5-yl)pyridin-3-yl]oxypropa n-2-amine
  • MW: 398.46 | Formula: C23H22N6O
  • H donors: 3 H acceptors: 3 LogP: 2.66 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@@H](Cc1c[nH]c2c1cccc2)COc1cncc(c1)c1ncc2c(c1)c(C)n[nH]2
  • InChi: 1S/C23H22N6O/c1-14-20-8-22(27-12-23(20)29-28-14)16-7-18(11-25-9-16)30-13-17(24)6-15-10-26-21-5-3-2-4-19(15)21/h2-5,7-12,17,26H,6,13,24H2,1H3,(H,28,29)/t17-/m0/s1
  • InChiKey: BNFMNOMUDQORMA-KRWDZBQOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-1-(1H-indol-3-yl)-3-[[5-(3-methyl-2H-pyrazolo[3,4-c]pyridin-5-yl)-3-pyridyl]oxy]propan-2-amine
  • (2S)-1-(1H-indol-3-yl)-3-[[5-(3-methyl-2H-pyrazolo[3,4-c]pyridin-5-yl)-3-pyridyl]oxy]-2-propanamine
  • (2S)-1-(1H-indol-3-yl)-3-[5-(3-methyl-2H-pyrazolo[3,4-c]pyridin-5-yl)pyridin-3-yl]oxy-propan-2-amine
  • [(1S)-1-(1H-indol-3-ylmethyl)-2-[[5-(3-methyl-2H-pyrazolo[3,4-c]pyridin-5-yl)-3-pyridyl]oxy]ethyl]amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein kinase, cAMP-dependent, catalytic, beta References
Homo sapiens protein kinase, cAMP-dependent, catalytic, gamma Starlite/ChEMBL References
Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha References
Homo sapiens v-akt murine thymoma viral oncogene homolog 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/RSK/P70 protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium knowlesi RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase 2, putative Get druggable targets OG5_126635 All targets in OG5_126635
Theileria parva cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Neospora caninum Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Cryptosporidium hominis protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium yoelii kinase Akt/PKB-related Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei protein kinase A catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium knowlesi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K07390 monothiol glutaredoxin, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi Protein kinase B Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium falciparum RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania infantum protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K08792 serum/glucocorticoid regulated kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis rac serine:threonine kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_126635 All targets in OG5_126635
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania mexicana protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus serine threonine protein kinase nrc Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania braziliensis protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium berghei rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva cAMP-dependent protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus calcium:calmodulin dependent protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans likely protein kinase similar to S. cerevisiae YPK2 (YMR104C) Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma congolense protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii AGC kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi p70 ribosomal S6 kinase beta Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126635 All targets in OG5_126635
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Protein kinase DC2, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04456 RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/AKT protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei protein lipid droplet kinase (LDK) protein kinase, cAMP-dependent, catalytic, beta 358 aa 320 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Trichomonas vaginalis glycogen phosphorylase, putative 0.1239 0.0928 1
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0003 0.0003
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0147 0.01 0.217
Leishmania major hypothetical protein, conserved 0.0057 0.0031 0.0263
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0031 0.0263
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0021 0.0021
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0134 0.009 0.1933
Onchocerca volvulus 0.0134 0.009 0.0908
Brugia malayi Protein-tyrosine phosphatase 1 0.0134 0.009 0.0401
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0186 0.0129 0.0576
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0021 0.0093
Echinococcus multilocularis Glutaredoxin protein 5 0.0025 0.0007 0.003
Onchocerca volvulus 0.0134 0.009 0.0908
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0021 0.0224
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0134 0.009 0.0401
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0134 0.009 0.0401
Echinococcus multilocularis glycogen phosphorylase 0.1239 0.0928 0.4142
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0134 0.009 0.009
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0144 0.0097 0.0435
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0134 0.009 0.0401
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0021 0.0093
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Entamoeba histolytica glycogen phosphorylase, putative 0.1239 0.0928 1
Brugia malayi hypothetical protein 0.0134 0.009 0.0401
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0134 0.009 0.0401
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0028
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0186 0.0129 0.139
Onchocerca volvulus 0.0134 0.009 0.0908
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0186 0.0129 0.139
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0134 0.009 0.0401
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0134 0.009 0.0401
Brugia malayi hypothetical protein 0.0134 0.009 0.0401
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.2401 0.1808 0.1808
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.002 0.0003 0.0015
Onchocerca volvulus 0.0134 0.009 0.0908
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0578 0.0427 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0021 0.0224
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0147 0.01 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0021 0.0224
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0134 0.009 0.0401
Brugia malayi C1-like domain containing protein 0.0044 0.0022 0.0097
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0186 0.0129 0.139
Echinococcus granulosus netrin receptor unc 5 0.0152 0.0103 0.046
Echinococcus multilocularis neuroligin 0.0024 0.0006 0.0028
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0147 0.01 0.217
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0044 0.0022 0.0097
Echinococcus granulosus serine/threonine protein kinase 0.0032 0.0012 0.0054
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.297 0.224 0.224
Trypanosoma brucei protein tyrosine phosphatase 1 0.0134 0.009 0.1702
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0031 0.0534
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0153 0.0104 0.0104
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0134 0.009 0.0401
Echinococcus granulosus nervana 2 0.0025 0.0007 0.003
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0134 0.009 0.0401
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0134 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Loa Loa (eye worm) glycogen phosphorylase 0.1239 0.0928 0.4142
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0134 0.009 0.0401
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0134 0.009 0.0401
Brugia malayi Uncoordinated protein 44 0.0152 0.0103 0.046
Onchocerca volvulus Netrin receptor homolog 0.0152 0.0103 0.1051
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0028
Onchocerca volvulus 0.0134 0.009 0.0908
Trypanosoma brucei RNA helicase, putative 0.0217 0.0153 0.3253
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0134 0.009 0.0401
Echinococcus granulosus neuroligin 0.0024 0.0006 0.0028
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0022 0.0233
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0147 0.01 0.0446
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.0103 0.046
Brugia malayi hypothetical protein 0.0134 0.009 0.0401
Schistosoma mansoni protein tyrosine phosphatase 0.0134 0.009 0.009
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0134 0.009 0.0401
Toxoplasma gondii hypothetical protein 0.0093 0.0059 0.0104
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Leishmania major tyrosine specific protein phosphatase, putative 0.0134 0.009 0.1702
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0147 0.01 0.0446
Schistosoma mansoni gliotactin 0.0024 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0152 0.0103 0.046
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Echinococcus granulosus Glutaredoxin protein 5 0.0025 0.0007 0.003
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0134 0.009 0.0401
Schistosoma mansoni hypothetical protein 0.0217 0.0153 0.0153
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0134 0.009 0.0401
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0147 0.01 0.1946
Giardia lamblia Glycogen phosphorylase 0.1239 0.0928 1
Onchocerca volvulus 0.0134 0.009 0.0908
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0134 0.009 0.0969
Schistosoma mansoni glycogen phosphorylase 0.1239 0.0928 0.0928
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0134 0.009 0.0401
Schistosoma mansoni netrin receptor unc5 0.0152 0.0103 0.0103
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0134 0.009 0.0401
Entamoeba histolytica glycogen phosphorylase, putative 0.0536 0.0394 0.4251
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0536 0.0394 1
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0003 0.0003
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0134 0.009 0.009
Entamoeba histolytica glycogen phosphorylase, putative 0.1239 0.0928 1
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0134 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0043 0.0021 0.0093
Echinococcus granulosus protein tyrosine phosphatase n9 0.0134 0.009 0.0401
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0186 0.0129 0.139
Onchocerca volvulus 0.0134 0.009 0.0908
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.01 0.01
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0246 0.0175 0.078
Entamoeba histolytica PH domain containing protein kinase, putative 0.0151 0.0103 0.1106
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0147 0.01 0.0446
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0134 0.009 0.0401
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0147 0.01 0.0446
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Onchocerca volvulus 0.0134 0.009 0.0908
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0134 0.009 0.0401
Schistosoma mansoni neuroligin 3 (S09 family) 0.0024 0.0006 0.0006
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0186 0.0129 0.3161
Echinococcus multilocularis carboxylesterase 5A 0.0142 0.0096 0.0427
Brugia malayi carbohydrate phosphorylase 0.1239 0.0928 0.4142
Onchocerca volvulus 0.0134 0.009 0.0908
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0021 0.0093
Brugia malayi Protein-tyrosine phosphatase 0.0134 0.009 0.0401
Echinococcus multilocularis 0.0134 0.009 0.0401
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0028
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0134 0.009 0.0401
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0003 0.0003
Brugia malayi Carboxylesterase family protein 0.0142 0.0096 0.0427
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0134 0.009 0.0401
Loa Loa (eye worm) carboxylesterase 0.0024 0.0006 0.0028
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Onchocerca volvulus 0.0134 0.009 0.0908
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0134 0.009 0.1933
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0134 0.009 0.0401
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0134 0.009 0.0401
Onchocerca volvulus 0.0134 0.009 0.0908
Entamoeba histolytica PH domain containing protein kinase, putative 0.0151 0.0103 0.1106
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.5101 0.3855 1
Schistosoma mansoni hypothetical protein 0.0152 0.0103 0.0103
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0021 0.0224
Trichomonas vaginalis spcc417.12 protein, putative 0.0024 0.0006 0.0067
Brugia malayi Protein-tyrosine phosphatase containing protein 0.297 0.224 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0134 0.009 0.0401
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0186 0.0129 0.0576
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0152 0.0103 0.046
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0134 0.009 0.009
Echinococcus granulosus BC026374 protein S09 family 0.0024 0.0006 0.0028
Brugia malayi Protein kinase domain containing protein 0.0044 0.0022 0.0096
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0578 0.0427 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0021 0.0093
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Echinococcus multilocularis protein kinase c epsilon type 0.002 0.0003 0.0015
Loa Loa (eye worm) hypothetical protein 0.0142 0.0096 0.0427
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0134 0.009 0.0401
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0134 0.009 0.0401
Schistosoma mansoni glycogen phosphorylase 0.1239 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0147 0.01 0.0446
Echinococcus granulosus death domain containing protein 0.0152 0.0103 0.046
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0134 0.009 0.0401
Brugia malayi Protein kinase domain containing protein 0.0155 0.0105 0.0471
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0134 0.009 0.0401
Toxoplasma gondii AGC kinase 0.0147 0.01 0.0211
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0152 0.0103 0.046
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0246 0.0175 0.078
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0274 0.0196 0.4307
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0134 0.009 0.0401
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0186 0.0129 0.139
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0274 0.0196 0.4466
Loa Loa (eye worm) protein tyrosine phosphatase 0.0134 0.009 0.0401
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0147 0.01 0.1946
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Leishmania major mitochondrial DNA polymerase beta 0.0578 0.0427 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0031 0.0339
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0134 0.009 0.0401
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0134 0.009 0.0401
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0134 0.009 0.009
Schistosoma mansoni serine/threonine-protein kinase 0.0032 0.0012 0.0012
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0099 0.0063 0.1294
Loa Loa (eye worm) hypothetical protein 0.0153 0.0104 0.0464
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0041 0.0019 0.0084
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Echinococcus multilocularis netrin receptor unc 5 0.0152 0.0103 0.046
Echinococcus multilocularis rac serine:threonine kinase 0.0032 0.0012 0.0054
Trichomonas vaginalis AGC family protein kinase 0.0147 0.01 0.1076
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0134 0.009 0.0401
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0134 0.009 0.0401
Entamoeba histolytica PH domain containing protein kinase, putative 0.0032 0.0012 0.0129
Echinococcus granulosus acetylcholinesterase 0.0142 0.0096 0.0427
Schistosoma mansoni BC026374 protein (S09 family) 0.0024 0.0006 0.0006
Echinococcus granulosus acetylcholinesterase 0.0142 0.0096 0.0427
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0134 0.009 0.0969
Echinococcus multilocularis Glycosyl transferase, family 35 0.1239 0.0928 0.4142
Entamoeba histolytica glycogen phosphorylase, putative 0.0536 0.0394 0.4251
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0186 0.0129 0.139
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0147 0.01 0.0446
Echinococcus granulosus Ankyrin 0.0153 0.0104 0.0464
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0147 0.01 0.0446
Echinococcus multilocularis nervana 2 0.0025 0.0007 0.003
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0274 0.0196 0.4307
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Schistosoma mansoni pcd6 interacting protein-related 0.0134 0.009 0.009
Brugia malayi Carboxylesterase family protein 0.0024 0.0006 0.0028
Echinococcus multilocularis acetylcholinesterase 0.0142 0.0096 0.0427
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0134 0.009 0.0401
Echinococcus granulosus protein kinase c iota type 0.002 0.0003 0.0015
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0134 0.009 0.009
Trypanosoma cruzi Protein kinase B 0.0032 0.0012 0.0067
Onchocerca volvulus 0.0134 0.009 0.0908
Onchocerca volvulus 4.1 G protein, putative homolog 0.0134 0.009 0.0908
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0021 0.0127
Leishmania major protein kinase A catalytic subunit isoform 2 0.0147 0.01 0.1946
Entamoeba histolytica PH domain containing protein kinase, putative 0.0032 0.0012 0.0129
Loa Loa (eye worm) protein-tyrosine phosphatase 0.297 0.224 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0021 0.0279
Loa Loa (eye worm) hypothetical protein 0.0041 0.0019 0.0086
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0021 0.0093
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0024 0.0006 0.0028
Onchocerca volvulus 0.0134 0.009 0.0908
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0147 0.01 0.0446
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0021 0.0021
Entamoeba histolytica protein kinase, putative 0.0044 0.0022 0.0233
Entamoeba histolytica glycogenphosphorylase, putative 0.0536 0.0394 0.4251
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Brugia malayi Carboxylesterase family protein 0.0024 0.0006 0.0028
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.0031 0.0339
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0134 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Echinococcus multilocularis Protein kinase C, brain isozyme 0.002 0.0003 0.0015
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0025 0.0007 0.003
Schistosoma mansoni protein tyrosine phosphatase 0.0134 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0028
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0081 0.005 0.0971
Loa Loa (eye worm) AGC/PKA protein kinase 0.0147 0.01 0.0446
Echinococcus granulosus protein kinase c epsilon type 0.002 0.0003 0.0015
Schistosoma mansoni ankyrin 23/unc44 0.0152 0.0103 0.0103
Brugia malayi protein kinase C II. 0.002 0.0003 0.0015
Toxoplasma gondii AGC kinase 0.0147 0.01 0.0211
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0134 0.009 0.0401
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0134 0.009 0.0401
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0246 0.0175 0.078
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0022 0.0233
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0134 0.009 0.0969
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0081 0.005 0.0971
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0246 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0028
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Brugia malayi hypothetical protein 0.0134 0.009 0.0401
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0134 0.009 0.0401
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0134 0.009 0.1702
Echinococcus granulosus para nitrobenzyl esterase 0.0024 0.0006 0.0028
Loa Loa (eye worm) AGC/AKT protein kinase 0.0044 0.0022 0.0096
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0134 0.009 0.0401
Echinococcus granulosus glycogen phosphorylase 0.1239 0.0928 0.4142
Entamoeba histolytica protein kinase, putative 0.0041 0.0019 0.0202
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0134 0.009 0.0401
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0134 0.009 0.0401
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Loa Loa (eye worm) hypothetical protein 0.0152 0.0103 0.046
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0147 0.01 0.0446
Entamoeba histolytica protein kinase, putative 0.0044 0.0022 0.0233
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0134 0.009 0.0401
Onchocerca volvulus 0.0134 0.009 0.0908
Onchocerca volvulus 0.0134 0.009 0.0908
Trichomonas vaginalis pten, drome, putative 0.0134 0.009 0.0969
Loa Loa (eye worm) hypothetical protein 0.0142 0.0096 0.0427
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0134 0.009 0.0401
Echinococcus multilocularis protein kinase c iota type 0.002 0.0003 0.0015
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0025 0.0007 0.003
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Echinococcus multilocularis hypothetical protein 0.0134 0.009 0.0401
Schistosoma mansoni protein tyrosine phosphatase 0.0134 0.009 0.009
Echinococcus multilocularis para nitrobenzyl esterase 0.0024 0.0006 0.0028
Onchocerca volvulus 0.0134 0.009 0.0908
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0028
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0134 0.009 0.0401
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0006 0.0006
Echinococcus granulosus serine threonine protein kinase nrc 0.0028 0.0009 0.0041
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0021 0.0093
Echinococcus granulosus Protein kinase C brain isozyme 0.002 0.0003 0.0015
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0147 0.01 0.1946
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0032 0.0012 0.0067
Schistosoma mansoni atypical protein kinase C 0.002 0.0003 0.0003
Echinococcus multilocularis Ankyrin 0.0153 0.0104 0.0464
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Echinococcus granulosus nuclear factor of activated T cells 5 0.1025 0.0766 0.3418
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0134 0.009 0.009
Brugia malayi Carboxylesterase family protein 0.0142 0.0096 0.0427
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0134 0.009 0.009
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0024 0.0006 0.0006
Echinococcus multilocularis nervana 2 0.0025 0.0007 0.003
Leishmania major protein kinase A catalytic subunit 0.0147 0.01 0.1946
Onchocerca volvulus Glycogen phosphorylase homolog 0.1239 0.0928 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0186 0.0129 0.139
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0147 0.01 0.0211
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0246 0.0175 0.078
Brugia malayi Carboxylesterase family protein 0.0024 0.0006 0.0028
Brugia malayi Carboxylesterase family protein 0.0024 0.0006 0.0028
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0081 0.005 0.0712
Onchocerca volvulus 0.0041 0.0019 0.0141
Entamoeba histolytica protein kinase 2, putative 0.0028 0.0009 0.0099
Trypanosoma brucei rac serine-threonine kinase, putative 0.0044 0.0022 0.0019
Chlamydia trachomatis glycogen phosphorylase 0.1239 0.0928 0.5
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0134 0.009 0.0401
Onchocerca volvulus 0.0134 0.009 0.0908
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Schistosoma mansoni serine/threonine-protein kinase 0.0032 0.0012 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0019 0.0003 0.003
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0134 0.009 0.0401
Brugia malayi Protein-tyrosine phosphatase 0.0134 0.009 0.0401
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.297 0.224 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.297 0.224 1
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0044 0.0022 0.0097
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0081 0.005 0.0971
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0144 0.0097 0.0435
Mycobacterium tuberculosis Conserved hypothetical protein 0.0305 0.0219 0.5483
Leishmania major protein kinase A catalytic subunit isoform 1 0.0147 0.01 0.1946
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0246 0.0175 0.078
Echinococcus multilocularis nuclear factor of activated T cells 5 0.1025 0.0766 0.3418
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0022 0.0233
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0024 0.0006 0.0067
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0147 0.01 0.217
Echinococcus granulosus glycogen phosphorylase 0.1239 0.0928 0.4142
Trichomonas vaginalis glycogen phosphorylase, putative 0.1239 0.0928 1
Echinococcus granulosus carboxylesterase 5A 0.0142 0.0096 0.0427
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0134 0.009 0.0401
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0071
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0134 0.009 0.1933
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0134 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Echinococcus multilocularis glycogen phosphorylase 0.1239 0.0928 0.4142
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0147 0.01 0.217
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.01 0.01
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0134 0.009 0.0401
Onchocerca volvulus 0.0134 0.009 0.0908
Onchocerca volvulus 0.0134 0.009 0.0908
Loa Loa (eye worm) hypothetical protein 0.0045 0.0022 0.0099
Onchocerca volvulus 0.0134 0.009 0.0908
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0134 0.009 0.009
Mycobacterium ulcerans hypothetical protein 0.0305 0.0219 0.5483
Onchocerca volvulus 0.0037 0.0016 0.0104
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0246 0.0175 0.078
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Loa Loa (eye worm) AGC/PKA protein kinase 0.0147 0.01 0.0446
Schistosoma mansoni protein kinase C mu 0.0044 0.0022 0.0022
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0134 0.009 0.0401
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Onchocerca volvulus 0.0186 0.0129 0.1331
Onchocerca volvulus 0.0134 0.009 0.0908
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.01 0.01
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0022 0.0233
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0022 0.0233
Loa Loa (eye worm) acetylcholinesterase 1 0.0142 0.0096 0.0427
Echinococcus multilocularis acetylcholinesterase 0.0142 0.0096 0.0427
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0134 0.009 0.0401
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0028 0.0009 0.0041
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0147 0.01 1
Onchocerca volvulus 0.0134 0.009 0.0908
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0031 0.0534
Brugia malayi hypothetical protein 0.0024 0.0006 0.0028
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0021 0.0093
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0028 0.0009 0.0041
Onchocerca volvulus 0.0045 0.0022 0.0172
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0578 0.0427 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0142 0.0096 0.0096
Brugia malayi hypothetical protein 0.0134 0.009 0.0401
Loa Loa (eye worm) carboxylesterase 0.0024 0.0006 0.0028
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0021 0.0279
Schistosoma mansoni glycogen phosphorylase 0.0536 0.0394 0.0394
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Loa Loa (eye worm) hypothetical protein 0.0024 0.0006 0.0028
Loa Loa (eye worm) CAMK/PKD protein kinase 0.004 0.0018 0.0081
Schistosoma mansoni acetylcholinesterase 0.0024 0.0006 0.0006
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0134 0.009 0.0401
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Giardia lamblia Kinase, AGC PKA 0.0147 0.01 0.0986
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0022 0.0233
Brugia malayi Death domain containing protein 0.0152 0.0103 0.046
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0536 0.0394 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0186 0.0129 0.139
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0129 0.0086 0.2042
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0134 0.009 0.0401
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0134 0.009 0.0401
Loa Loa (eye worm) hypothetical protein 0.0037 0.0016 0.0071
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0024 0.0006 0.0028
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0134 0.009 0.0401
Echinococcus granulosus Glycosyl transferase family 35 0.1239 0.0928 0.4142
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0186 0.0129 0.1304
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0022 0.0233
Loa Loa (eye worm) carboxylesterase 0.0142 0.0096 0.0427
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0134 0.009 0.0401
Giardia lamblia Protein tyrosine phosphatase 0.0134 0.009 0.0878
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0134 0.009 0.009
Brugia malayi p70 ribosomal S6 kinase beta 0.0041 0.0019 0.0084
Echinococcus multilocularis BC026374 protein (S09 family) 0.0024 0.0006 0.0028
Onchocerca volvulus 0.0134 0.009 0.0908
Loa Loa (eye worm) hypothetical protein 0.0134 0.009 0.0401
Echinococcus granulosus nervana 2 0.0025 0.0007 0.003

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.041 uM Antiproliferative activity against MiaPaCa cells by MTT assay ChEMBL. 17258463
EC50 (functional) = 0.041 uM Antiproliferative activity against MiaPaCa cells by MTT assay ChEMBL. 17258463
IC50 (binding) = 0.34 nM Inhibition of Akt1 ChEMBL. 17258463
IC50 (binding) = 0.34 nM Inhibition of Akt1 ChEMBL. 17258463
IC50 (binding) = 0.34 nM Inhibition of Akt ChEMBL. 19497644
IC50 (binding) = 15 nM Inhibition of PKA ChEMBL. 17258463
IC50 (binding) = 15 nM Inhibition of PKA ChEMBL. 17258463

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 17258463

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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