TDR Targets

Basic information

Technical information

TDR Targets ID: 432865
Name: (2,2-dimethyl-1,3-dioxolan-4-yl)methyl (5Z,8Z ,11Z,14Z)-icosa-5,8,11,14-tetraenoate
MW: 418.609 | Formula: C26H42O4
H donors: 0 H acceptors: 1 LogP: 6.88 Rotable bonds: 17
Rule of 5 violations (Lipinski): 1
SMILES: CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)OCC1COC(O1)(C)C
InChi: 1S/C26H42O4/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(27)28-22-24-23-29-26(2,3)30-24/h8-9,11-12,14-15,17-18,24H,4-7,10,13,16,19-23H2,1-3H3/b9-8-,12-11-,15-14-,18-17-
InChiKey: ZWEJNTPCOYFONY-GKFVBPDJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid (2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0044	0.0073	0.1082
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0044	0.0073	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0038	0.0055	0.0055
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0038	0.0055	0.0863
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0044	0.0073	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0334	0.5218
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0044	0.0073	0.1082
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0128	0.0334	0.0334
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0044	0.0073	0.0191
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Brugia malayi	Sugar transporter family protein	0.0021	0.0004	0.0069
Onchocerca volvulus		0.0044	0.0073	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0038	0.0055	0.0863
Schistosoma mansoni	glucose transporter	0.0021	0.0004	0.0069
Brugia malayi	Nuclear hormone receptor-like 1	0.0038	0.0055	0.0863
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0038	0.0055	0.0863
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0044	0.0073	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0044	0.0073	0.1082
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0044	0.0073	0.1082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Brugia malayi	nuclear receptor NHR-88	0.0038	0.0055	0.0863
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0227	0.0639	0.0639
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0227	0.0639	1
Schistosoma mansoni	nuclear hormone receptor	0.0038	0.0055	0.0863
Echinococcus multilocularis	FTZ F1 alpha	0.0038	0.0055	0.0055
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0038	0.0055	0.0055
Brugia malayi	Major Facilitator Superfamily protein	0.0021	0.0004	0.0069
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.3258	1	1
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0044	0.0073	0.0073
Brugia malayi	Sugar transporter family protein	0.0021	0.0004	0.0069
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0227	0.0639	0.1769
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0038	0.0055	0.0863
Onchocerca volvulus		0.0038	0.0055	0.739
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0044	0.0073	0.1082
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0044	0.0073	0.0073
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0227	0.0639	0.1838
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0038	0.0055	0.0055
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0143	0.0379	0.5897
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0044	0.0073	0.1143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0227	0.0639	0.1769
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0021	0.0004	0.0069
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0038	0.0055	0.0863
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0038	0.0055	0.0863
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0073	0.1143
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0044	0.0073	0.0199
Brugia malayi	nuclear hormone receptor	0.0038	0.0055	0.0863
Brugia malayi	Major Facilitator Superfamily protein	0.0021	0.0004	0.0069
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0227	0.0639	0.1838
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0044	0.0073	0.1143
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0044	0.0073	0.1082
Trypanosoma cruzi	hypothetical protein, conserved	0.114	0.3457	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0038	0.0055	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0038	0.0055	0.0863
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Echinococcus multilocularis		0.0044	0.0073	0.0073
Schistosoma mansoni	coup transcription factor	0.0038	0.0055	0.0863
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0038	0.0055	0.0055
Onchocerca volvulus	Protein ultraspiracle homolog	0.0038	0.0055	0.739
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0044	0.0073	0.0199
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0227	0.0639	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0044	0.0073	0.1082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0038	0.0055	0.0863
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0227	0.0639	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0073	0.1143
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0227	0.0639	0.1838
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0038	0.0055	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0128	0.0334	0.5185
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0044	0.0073	0.0199
Echinococcus multilocularis	solute carrier family 22	0.0021	0.0004	0.0004
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0073	0.1143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Onchocerca volvulus		0.0044	0.0073	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0044	0.0073	0.0199
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0073	0.1143
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0044	0.0073	0.1082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0128	0.0334	0.5185
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0244	0.3815
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0069
Loa Loa (eye worm)	sugar transporter	0.0021	0.0004	0.0069
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0044	0.0073	0.1082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0128	0.0334	0.0953
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0044	0.0073	0.0073
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0038	0.0055	0.0863
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0044	0.0073	0.0073
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0038	0.0055	0.0863
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0128	0.0334	0.4601
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0044	0.0073	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0055	0.0863
Schistosoma mansoni	hypothetical protein	0.0021	0.0004	0.0069
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0044	0.0073	0.1143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0227	0.0639	1
Echinococcus granulosus	solute carrier family 22	0.0021	0.0004	0.0004
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0227	0.0639	0.0639
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0044	0.0073	0.0191
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0128	0.0334	0.5185
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0227	0.0639	0.1769
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0021	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0069
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0038	0.0055	0.0055
Schistosoma mansoni	hypothetical protein	0.0044	0.0073	0.1143
Schistosoma mansoni	sugar transporter	0.0021	0.0004	0.0069
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0128	0.0334	0.5185
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0123	0.0318	0.0318
Brugia malayi	hypothetical protein	0.0021	0.0004	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0055	0.0863
Giardia lamblia	Hypothetical protein	0.0044	0.0073	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0069
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0038	0.0055	0.0863
Echinococcus multilocularis	solute carrier family 22	0.0021	0.0004	0.0004
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0038	0.0055	0.0055
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0044	0.0073	0.1143
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0044	0.0073	0.1143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0073	0.1143
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0073	0.1143
Loa Loa (eye worm)	sugar transporter	0.0021	0.0004	0.0069
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0021	0.0004	0.0069
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0044	0.0073	0.0073
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0044	0.0073	0.1082
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0227	0.0639	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0044	0.0073	0.1143
Brugia malayi	Steroid receptor seven-up type 2	0.0038	0.0055	0.0863
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0128	0.0334	0.5185
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0038	0.0055	0.0863
Mycobacterium leprae	conserved hypothetical protein	0.0044	0.0073	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0038	0.0055	0.0863
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0038	0.0055	0.0055
Schistosoma mansoni	sugar transporter	0.0021	0.0004	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0084	0.0199	0.306
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0038	0.0055	0.0055
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0044	0.0073	0.1143
Onchocerca volvulus	Bile acid receptor homolog	0.0038	0.0055	0.739
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0021	0.0004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0055	0.0863
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0044	0.0073	1
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0044	0.0073	0.0073
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0044	0.0073	0.1082
Entamoeba histolytica	hypothetical protein	0.0128	0.0334	0.4601
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0128	0.0334	0.5218
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0021	0.0004	0.0004
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0021	0.0004	0.0004
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0044	0.0073	0.0199
Brugia malayi	amidase	0.0123	0.0318	0.498
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0044	0.0073	0.0199
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0227	0.0639	0.1838
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0038	0.0055	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0318	0.498
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0044	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0069
Loa Loa (eye worm)	steroid hormone receptor	0.0038	0.0055	0.0863
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Schistosoma mansoni	thyroid hormone receptor	0.0038	0.0055	0.0863
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0021	0.0004	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Echinococcus multilocularis	serine protein kinase ATM	0.0128	0.0334	0.0334
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0227	0.0639	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0084	0.0199	0.306
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0044	0.0073	0.1082
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0038	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0199	0.3109
Brugia malayi	steroid hormone receptor	0.0038	0.0055	0.0863
Brugia malayi	photoreceptor-specific nuclear receptor	0.0038	0.0055	0.0863
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0073	0.1143
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0044	0.0073	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0069
Schistosoma mansoni	glucose transport protein	0.0021	0.0004	0.0069
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0044	0.0073	0.0073
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0227	0.0639	1
Schistosoma mansoni	fatty-acid amide hydrolase	0.0123	0.0318	0.498
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0073	0.1143
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0123	0.0318	0.0318
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0227	0.0639	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0055	0.0863
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0044	0.0073	0.0073
Trichomonas vaginalis	conserved hypothetical protein	0.0099	0.0244	0.3772
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0038	0.0055	0.0055
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0044	0.0073	0.1082
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0073	0.1143
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0227	0.0639	0.1769
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0038	0.0055	0.0863
Echinococcus granulosus	FTZ F1 alpha	0.0038	0.0055	0.0055
Toxoplasma gondii	FATC domain-containing protein	0.0128	0.0334	0.5185
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0055	0.0863
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0038	0.0055	0.0863
Brugia malayi	Major Facilitator Superfamily protein	0.0021	0.0004	0.0069
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0128	0.0334	0.5218
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0038	0.0055	0.0055
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0038	0.0055	0.0863
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0038	0.0055	0.0863
Echinococcus multilocularis	Zinc finger, PHD finger	0.0044	0.0073	0.0073
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0038	0.0055	0.0863
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0044	0.0073	0.0191
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0123	0.0318	0.0318
Schistosoma mansoni	sugar transporter	0.0021	0.0004	0.0069
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0021	0.0004	0.0004
Leishmania major	hypothetical protein, unknown function	0.0044	0.0073	0.0191
Plasmodium vivax	hypothetical protein, conserved	0.0044	0.0073	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0069
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0128	0.0334	0.5218
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0055	0.0863
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0128	0.0334	0.5185
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0038	0.0055	0.0863
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0021	0.0004	0.0004
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0044	0.0073	0.0073
Echinococcus granulosus	ecdysone induced protein 78C	0.0038	0.0055	0.0055
Echinococcus granulosus	serine protein kinase ATM	0.0128	0.0334	0.0334
Schistosoma mansoni	hypothetical protein	0.0099	0.0244	0.3815
Schistosoma mansoni	amidase	0.0123	0.0318	0.498
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0038	0.0055	0.0863
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0021	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0143	0.0379	0.5897
Mycobacterium ulcerans	sugar transporter	0.0021	0.0004	0.5
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0227	0.0639	0.0639
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0044	0.0073	0.1082
Schistosoma mansoni	sugar transporter	0.0021	0.0004	0.0069
Echinococcus multilocularis	solute carrier family 22	0.0021	0.0004	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0128	0.0334	0.5185
Echinococcus multilocularis	solute carrier family 22	0.0021	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0021	0.0004	0.0069
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0044	0.0073	0.1082
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0044	0.0073	0.1143
Brugia malayi	major facilitator superfamily protein	0.0021	0.0004	0.0069
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0044	0.0073	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0055	0.0863
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0044	0.0073	0.0199
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0044	0.0073	0.1082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0073	0.1082
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0044	0.0073	0.1082
Loa Loa (eye worm)	phosphatidylinositol 3	0.0227	0.0639	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.0227	0.0639	0.1838
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0044	0.0073	0.1082
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0128	0.0334	0.0334
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0073	0.1082
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0044	0.0073	0.0199
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0099	0.0244	0.0244
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0227	0.0639	0.1769
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0128	0.0334	0.5185
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0021	0.0004	0.0004
Brugia malayi	major facilitator superfamily protein	0.0021	0.0004	0.0069
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0073	0.1143
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0021	0.0004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0069
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0038	0.0055	0.0863
Brugia malayi	ecdysteroid receptor	0.0038	0.0055	0.0863
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0044	0.0073	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0038	0.0055	0.0055
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0084	0.0199	0.0563
Echinococcus granulosus	synaptic vesicle 2 protein	0.0021	0.0004	0.0004
Brugia malayi	FAT domain containing protein	0.0099	0.0244	0.3815
Mycobacterium ulcerans	integral membrane transport protein	0.0021	0.0004	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0069
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0021	0.0004	0.0004
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0044	0.0073	0.1082
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0073	0.1143
Entamoeba histolytica	protein kinase rad3, putative	0.0128	0.0334	0.4601
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0044	0.0073	1
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0044	0.0073	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0143	0.0379	0.5897
Echinococcus granulosus	solute carrier family 22	0.0021	0.0004	0.0004
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0021	0.0004	0.5
Leishmania major	hypothetical protein, conserved	0.1183	0.3592	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.0073	0.1143
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0038	0.0055	0.0863
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0044	0.0073	0.1143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0143	0.0379	0.5897
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0044	0.0073	0.1082
Schistosoma mansoni	thyroid hormone receptor	0.0038	0.0055	0.0863
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.0073	0.1143
Giardia lamblia	GTOR	0.0227	0.0639	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0038	0.0055	0.0863
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0044	0.0073	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0069
Brugia malayi	hypothetical protein	0.0021	0.0004	0.0069
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0021	0.0004	0.0069
Schistosoma mansoni	glucose transport protein	0.0021	0.0004	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0143	0.0379	0.5925
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0038	0.0055	0.0055
Schistosoma mansoni	glucose transport protein	0.0021	0.0004	0.0069
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0044	0.0073	0.1082
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0069
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0099	0.0244	0.0244
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0044	0.0073	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0044	0.0073	0.1082
Echinococcus granulosus	solute carrier family 22	0.0021	0.0004	0.0004
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0128	0.0334	0.5218
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.0073	0.1082
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0227	0.0639	0.0639
Echinococcus granulosus	solute carrier family 22	0.0021	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0069
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0227	0.0639	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0044	0.0073	0.1082
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0227	0.0639	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0227	0.0639	1
Brugia malayi	Sugar transporter family protein	0.0021	0.0004	0.0069
Schistosoma mansoni	retinoic acid receptor RXR	0.0038	0.0055	0.0863
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0038	0.0055	0.0863
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0044	0.0073	0.0191
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0123	0.0318	0.0318
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0128	0.0334	0.5185
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0021	0.0004	0.0004
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0227	0.0639	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0038	0.0055	0.739
Leishmania major	phosphatidylinositol kinase, putative	0.0044	0.0073	0.0191
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0044	0.0073	0.1082
Plasmodium vivax	hypothetical protein	0.0044	0.0073	1
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0044	0.0073	0.0073
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0021	0.0004	0.0004
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0038	0.0055	0.0863
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0227	0.0639	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0069
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0038	0.0055	0.0863
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0038	0.0055	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0004	0.0069
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0128	0.0334	0.0953
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0055	0.0863
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0044	0.0073	0.0073
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0044	0.0073	0.1143
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0227	0.0639	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 45 uM	Inhibition of MGL in rat cerebellum cytosolic fractions assessed as [3H]-2-oleoglycerol hydrolysis	ChEMBL.	17764163
IC50 (binding)	= 45 uM	Inhibition of MGL in rat cerebellum cytosolic fractions assessed as [3H]-2-oleoglycerol hydrolysis	ChEMBL.	17764163
IC50 (binding)	= 95 uM	Inhibition of MGL in rat cerebellum membrane fractions assessed as [3H]-2-oleoglycerol hydrolysis	ChEMBL.	17764163
IC50 (binding)	= 95 uM	Inhibition of MGL in rat cerebellum membrane fractions assessed as [3H]-2-oleoglycerol hydrolysis	ChEMBL.	17764163
IC50 (binding)	= 98 uM	Inhibition of FAAH in rat cerebellum membranes assessed as [3H]anandamide hydrolysis	ChEMBL.	17764163
IC50 (binding)	= 98 uM	Inhibition of FAAH in rat cerebellum membranes assessed as [3H]anandamide hydrolysis	ChEMBL.	17764163
Log I50 (binding)	= 4	Inhibition of MGL in rat cerebellum membrane fractions assessed as [3H]-2-oleoglycerol hydrolysis	ChEMBL.	17764163
Log I50 (binding)	= 4	Inhibition of FAAH in rat cerebellum membranes assessed as [3H]anandamide hydrolysis	ChEMBL.	17764163
Log I50 (binding)	= 4.3	Inhibition of MGL in rat cerebellum cytosolic fractions assessed as [3H]-2-oleoglycerol hydrolysis	ChEMBL.	17764163

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL230225
PubChem: 23624905

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 432865