Detailed information for compound 432898

Basic information

Technical information
  • TDR Targets ID: 432898
  • Name: [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ( 5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
  • MW: 418.609 | Formula: C26H42O4
  • H donors: 0 H acceptors: 1 LogP: 6.88 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)OC[C@@H]1COC(O1)(C)C
  • InChi: 1S/C26H42O4/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(27)28-22-24-23-29-26(2,3)30-24/h8-9,11-12,14-15,17-18,24H,4-7,10,13,16,19-23H2,1-3H3/b9-8-,12-11-,15-14-,18-17-/t24-/m1/s1
  • InChiKey: ZWEJNTPCOYFONY-LRGPLKKISA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Anandamide amidohydrolase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus multilocularis fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W) Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma mansoni fatty-acid amide hydrolase Get druggable targets OG5_127783 All targets in OG5_127783
Echinococcus granulosus fatty acid amide hydrolase 1 Get druggable targets OG5_127783 All targets in OG5_127783
Candida albicans hypothetical protein Get druggable targets OG5_127783 All targets in OG5_127783
Schistosoma mansoni amidase Get druggable targets OG5_127783 All targets in OG5_127783
Brugia malayi amidase Get druggable targets OG5_127783 All targets in OG5_127783
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum Fatty-acid amide hydrolase 1, putative Anandamide amidohydrolase   579 aa 499 aa 24.6 %
Echinococcus multilocularis fatty acid amide hydrolase 1 Anandamide amidohydrolase   579 aa 470 aa 28.3 %
Onchocerca volvulus Anandamide amidohydrolase   579 aa 539 aa 34.7 %
Echinococcus granulosus fatty acid amide hydrolase 1 Anandamide amidohydrolase   579 aa 470 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0044 0.0073 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0055 0.0863
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0227 0.0639 0.1838
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0044 0.0073 0.0199
Loa Loa (eye worm) hypothetical protein 0.0123 0.0318 0.498
Entamoeba histolytica hypothetical protein 0.0128 0.0334 0.4601
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0044 0.0073 0.0073
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0044 0.0073 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0044 0.0073 0.1082
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0044 0.0073 0.0199
Brugia malayi amidase 0.0123 0.0318 0.498
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0128 0.0334 0.5218
Echinococcus multilocularis synaptic vesicle 2 protein 0.0021 0.0004 0.0004
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0021 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0055 0.0863
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0021 0.0004 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0038 0.0055 0.0863
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0038 0.0055 0.0055
Mycobacterium leprae conserved hypothetical protein 0.0044 0.0073 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0038 0.0055 0.739
Schistosoma mansoni sugar transporter 0.0021 0.0004 0.0069
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0044 0.0073 0.1143
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0199 0.306
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.0334 0.5185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0038 0.0055 0.0863
Toxoplasma gondii target of rapamycin (TOR), putative 0.0227 0.0639 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0044 0.0073 0.1082
Brugia malayi Steroid receptor seven-up type 2 0.0038 0.0055 0.0863
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0044 0.0073 0.1143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0044 0.0073 0.1143
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.1143
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0073 0.1143
Loa Loa (eye worm) sugar transporter 0.0021 0.0004 0.0069
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0021 0.0004 0.0069
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0044 0.0073 0.0073
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0044 0.0073 0.1143
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0038 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0069
Echinococcus multilocularis solute carrier family 22 0.0021 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0055 0.0863
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0069
Brugia malayi hypothetical protein 0.0021 0.0004 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.0334 0.5185
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 0.0318 0.0318
Giardia lamblia Hypothetical protein 0.0044 0.0073 0.1082
Loa Loa (eye worm) hypothetical protein 0.0038 0.0055 0.0863
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0055 0.0055
Schistosoma mansoni sugar transporter 0.0021 0.0004 0.0069
Schistosoma mansoni hypothetical protein 0.0044 0.0073 0.1143
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0128 0.0334 0.5185
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0021 0.0004 0.0004
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0227 0.0639 0.1769
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0069
Loa Loa (eye worm) hypothetical protein 0.0038 0.0055 0.0863
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0044 0.0073 0.1143
Schistosoma mansoni hypothetical protein 0.0021 0.0004 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0227 0.0639 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0073 0.1082
Leishmania major phosphatidylinositol 4-kinase, putative 0.0044 0.0073 0.0191
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0227 0.0639 0.0639
Echinococcus granulosus solute carrier family 22 0.0021 0.0004 0.0004
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0044 0.0073 0.0073
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0038 0.0055 0.0863
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0044 0.0073 0.0073
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0038 0.0055 0.0863
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0128 0.0334 0.4601
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0044 0.0073 0.1082
Loa Loa (eye worm) sugar transporter 0.0021 0.0004 0.0069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0069
Loa Loa (eye worm) hypothetical protein 0.0099 0.0244 0.3815
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0128 0.0334 0.0953
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0073 0.1143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0044 0.0073 0.0199
Onchocerca volvulus 0.0044 0.0073 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0044 0.0073 0.1082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.0334 0.5185
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0073 0.1143
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0227 0.0639 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.1143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.0334 0.5185
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0044 0.0073 0.0199
Echinococcus multilocularis solute carrier family 22 0.0021 0.0004 0.0004
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0227 0.0639 0.1838
Echinococcus multilocularis thyroid hormone receptor alpha 0.0038 0.0055 0.0055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0055 0.0863
Onchocerca volvulus Protein ultraspiracle homolog 0.0038 0.0055 0.739
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0044 0.0073 0.0199
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0038 0.0055 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0044 0.0073 0.1082
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0227 0.0639 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Schistosoma mansoni RAR-like nuclear receptor 0.0038 0.0055 0.0863
Schistosoma mansoni coup transcription factor 0.0038 0.0055 0.0863
Echinococcus multilocularis 0.0044 0.0073 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0038 0.0055 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.114 0.3457 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0044 0.0073 0.1082
Loa Loa (eye worm) phosphatidylinositol kinase 0.0044 0.0073 0.1143
Loa Loa (eye worm) major facilitator superfamily transporter 0.0021 0.0004 0.0069
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0038 0.0055 0.0863
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0227 0.0639 0.1769
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0044 0.0073 0.0199
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0038 0.0055 0.0863
Brugia malayi nuclear hormone receptor 0.0038 0.0055 0.0863
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0073 0.1143
Brugia malayi Major Facilitator Superfamily protein 0.0021 0.0004 0.0069
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0227 0.0639 0.1838
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0044 0.0073 0.1143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0143 0.0379 0.5897
Schistosoma mansoni steroid hormone receptor ad4bp 0.0038 0.0055 0.0863
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0227 0.0639 0.1769
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0044 0.0073 0.1082
Onchocerca volvulus 0.0038 0.0055 0.739
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0055 0.0055
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0227 0.0639 0.1838
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0044 0.0073 0.0073
Echinococcus multilocularis FTZ F1 alpha 0.0038 0.0055 0.0055
Brugia malayi Major Facilitator Superfamily protein 0.0021 0.0004 0.0069
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0055 0.0055
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3258 1 1
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0055 0.0863
Brugia malayi Sugar transporter family protein 0.0021 0.0004 0.0069
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0044 0.0073 0.0073
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0044 0.0073 0.1082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0044 0.0073 0.1082
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0227 0.0639 0.0639
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0227 0.0639 1
Brugia malayi nuclear receptor NHR-88 0.0038 0.0055 0.0863
Schistosoma mansoni glucose transporter 0.0021 0.0004 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0038 0.0055 0.0863
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0044 0.0073 1
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0055 0.0863
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Brugia malayi Sugar transporter family protein 0.0021 0.0004 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0038 0.0055 0.0863
Onchocerca volvulus 0.0044 0.0073 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0044 0.0073 0.1082
Loa Loa (eye worm) hypothetical protein 0.0128 0.0334 0.5218
Leishmania major phosphatidylinositol 3-kinase, putative 0.0044 0.0073 0.0191
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0128 0.0334 0.0334
Echinococcus multilocularis ecdysone induced protein 78C 0.0038 0.0055 0.0055
Mycobacterium tuberculosis Conserved hypothetical protein 0.0044 0.0073 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0044 0.0073 0.1082
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0044 0.0073 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0038 0.0055 0.0863
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0044 0.0073 0.1143
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0038 0.0055 0.0863
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0038 0.0055 0.0863
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0069
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0128 0.0334 0.0953
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0044 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0038 0.0055 0.0863
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0021 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0069
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0055 0.0863
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0227 0.0639 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0227 0.0639 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0021 0.0004 0.0004
Plasmodium vivax hypothetical protein 0.0044 0.0073 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0044 0.0073 0.1082
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0044 0.0073 0.0073
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0038 0.0055 0.739
Leishmania major phosphatidylinositol kinase, putative 0.0044 0.0073 0.0191
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0044 0.0073 0.0191
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 0.0318 0.0318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.0334 0.5185
Loa Loa (eye worm) phosphatidylinositol 3 0.0227 0.0639 1
Brugia malayi Sugar transporter family protein 0.0021 0.0004 0.0069
Schistosoma mansoni retinoic acid receptor RXR 0.0038 0.0055 0.0863
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0038 0.0055 0.0863
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0069
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0227 0.0639 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0227 0.0639 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0044 0.0073 0.1082
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0128 0.0334 0.5218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0073 0.1082
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0227 0.0639 0.0639
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0044 0.0073 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0044 0.0073 0.1082
Echinococcus granulosus solute carrier family 22 0.0021 0.0004 0.0004
Echinococcus granulosus solute carrier family 22 0.0021 0.0004 0.0004
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0044 0.0073 0.1082
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0038 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0143 0.0379 0.5925
Schistosoma mansoni glucose transport protein 0.0021 0.0004 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0069
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0099 0.0244 0.0244
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0044 0.0073 0.0199
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0038 0.0055 0.0863
Schistosoma mansoni glucose transport protein 0.0021 0.0004 0.0069
Brugia malayi hypothetical protein 0.0021 0.0004 0.0069
Loa Loa (eye worm) major facilitator superfamily transporter 0.0021 0.0004 0.0069
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0055 0.0863
Trichomonas vaginalis PIKK family atypical protein kinase 0.0143 0.0379 0.5897
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0044 0.0073 0.1082
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0073 0.1143
Giardia lamblia GTOR 0.0227 0.0639 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0073 0.1143
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0038 0.0055 0.0863
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0021 0.0004 0.5
Leishmania major hypothetical protein, conserved 0.1183 0.3592 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0044 0.0073 0.1143
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0073 0.1143
Entamoeba histolytica protein kinase rad3, putative 0.0128 0.0334 0.4601
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0044 0.0073 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0044 0.0073 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0143 0.0379 0.5897
Echinococcus granulosus solute carrier family 22 0.0021 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0069
Brugia malayi FAT domain containing protein 0.0099 0.0244 0.3815
Mycobacterium ulcerans integral membrane transport protein 0.0021 0.0004 0.5
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0021 0.0004 0.0004
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0044 0.0073 0.1082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0044 0.0073 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0038 0.0055 0.0055
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0084 0.0199 0.0563
Brugia malayi ecdysteroid receptor 0.0038 0.0055 0.0863
Echinococcus granulosus synaptic vesicle 2 protein 0.0021 0.0004 0.0004
Brugia malayi major facilitator superfamily protein 0.0021 0.0004 0.0069
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0073 0.1143
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0021 0.0004 0.5
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0038 0.0055 0.0863
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0099 0.0244 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0227 0.0639 0.1769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.0334 0.5185
Echinococcus granulosus Sugar transporter ERD6 protein 0.0021 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0128 0.0334 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0073 0.1082
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0044 0.0073 0.0199
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0044 0.0073 0.0199
Loa Loa (eye worm) hypothetical protein 0.0038 0.0055 0.0863
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0044 0.0073 0.1082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0073 0.1082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0227 0.0639 0.1838
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0044 0.0073 0.1082
Loa Loa (eye worm) phosphatidylinositol 3 0.0227 0.0639 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0044 0.0073 0.1082
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0044 0.0073 0.1143
Brugia malayi major facilitator superfamily protein 0.0021 0.0004 0.0069
Giardia lamblia Phosphatidylinositol 4-kinase 0.0044 0.0073 0.1082
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0044 0.0073 1
Echinococcus multilocularis solute carrier family 22 0.0021 0.0004 0.0004
Echinococcus multilocularis solute carrier family 22 0.0021 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.0334 0.5185
Brugia malayi hypothetical protein 0.0021 0.0004 0.0069
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0044 0.0073 0.1082
Schistosoma mansoni sugar transporter 0.0021 0.0004 0.0069
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0021 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0038 0.0055 0.0863
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0069
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0227 0.0639 0.0639
Mycobacterium ulcerans sugar transporter 0.0021 0.0004 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0379 0.5897
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0044 0.0073 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0038 0.0055 0.0863
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0021 0.0004 0.0004
Schistosoma mansoni amidase 0.0123 0.0318 0.498
Echinococcus granulosus ecdysone induced protein 78C 0.0038 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0099 0.0244 0.3815
Echinococcus granulosus serine protein kinase ATM 0.0128 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0069
Schistosoma mansoni fkbp-rapamycin associated protein 0.0128 0.0334 0.5218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0073 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0055 0.0863
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.0334 0.5185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Schistosoma mansoni sugar transporter 0.0021 0.0004 0.0069
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0123 0.0318 0.0318
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0021 0.0004 0.0004
Leishmania major hypothetical protein, unknown function 0.0044 0.0073 0.0191
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0128 0.0334 0.5218
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0038 0.0055 0.0863
Brugia malayi Major Facilitator Superfamily protein 0.0021 0.0004 0.0069
Echinococcus multilocularis Zinc finger, PHD finger 0.0044 0.0073 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0038 0.0055 0.0863
Leishmania major phosphatidylinositol kinase related protein, putative 0.0044 0.0073 0.0191
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0038 0.0055 0.0055
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0038 0.0055 0.0863
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0038 0.0055 0.0863
Echinococcus granulosus FTZ F1 alpha 0.0038 0.0055 0.0055
Toxoplasma gondii FATC domain-containing protein 0.0128 0.0334 0.5185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0055 0.0863
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0244 0.3772
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0044 0.0073 0.0073
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0038 0.0055 0.0055
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0227 0.0639 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0055 0.0863
Leishmania major phosphatidylinositol 3-kinase, putative 0.0227 0.0639 0.1769
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0038 0.0055 0.0863
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0073 0.1143
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0044 0.0073 0.1082
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0044 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0069
Schistosoma mansoni glucose transport protein 0.0021 0.0004 0.0069
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0073 0.1143
Echinococcus granulosus fatty acid amide hydrolase 1 0.0123 0.0318 0.0318
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0227 0.0639 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0123 0.0318 0.498
Brugia malayi steroid hormone receptor 0.0038 0.0055 0.0863
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0073 0.1143
Brugia malayi photoreceptor-specific nuclear receptor 0.0038 0.0055 0.0863
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0044 0.0073 0.1082
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0038 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0084 0.0199 0.3109
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0044 0.0073 0.1082
Loa Loa (eye worm) steroid hormone receptor 0.0038 0.0055 0.0863
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0021 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Schistosoma mansoni thyroid hormone receptor 0.0038 0.0055 0.0863
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0639 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0004 0.0069
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0227 0.0639 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.0199 0.306
Echinococcus multilocularis serine protein kinase ATM 0.0128 0.0334 0.0334

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 17 uM Inhibition of FAAH in rat cerebellum membranes assessed as [3H]anandamide hydrolysis ChEMBL. 17764163
IC50 (binding) = 17 uM Inhibition of FAAH in rat cerebellum membranes assessed as [3H]anandamide hydrolysis ChEMBL. 17764163
Inhibition (binding) = 38 % Inhibition of MGL in rat cerebellum membrane fractions assessed as [3H]-2-oleoglycerol hydrolysis at 100 uM ChEMBL. 17764163
Inhibition (binding) = 38 % Inhibition of MGL in rat cerebellum membrane fractions assessed as [3H]-2-oleoglycerol hydrolysis at 100 uM ChEMBL. 17764163
Inhibition (binding) = 46 % Inhibition of MGL in rat cerebellum cytosolic fractions assessed as [3H]-2-oleoglycerol hydrolysis at 100 uM ChEMBL. 17764163
Inhibition (binding) = 46 % Inhibition of MGL in rat cerebellum cytosolic fractions assessed as [3H]-2-oleoglycerol hydrolysis at 100 uM ChEMBL. 17764163
Log I50 (binding) = 4.76 Inhibition of FAAH in rat cerebellum membranes assessed as [3H]anandamide hydrolysis ChEMBL. 17764163
Log I50 (binding) < 4 Inhibition of MGL in rat cerebellum cytosolic fractions assessed as [3H]-2-oleoglycerol hydrolysis ChEMBL. 17764163
Log I50 (binding) < 4 Inhibition of MGL in rat cerebellum membrane fractions assessed as [3H]-2-oleoglycerol hydrolysis ChEMBL. 17764163
Log I50 (binding) = 4.76 Inhibition of FAAH in rat cerebellum membranes assessed as [3H]anandamide hydrolysis ChEMBL. 17764163

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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