TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 370.484 | Formula: C19H34N2O5
H donors: 3 H acceptors: 5 LogP: 3.64 Rotable bonds: 18
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCCCC(=O)C(=O)N[C@@H](C(=O)NCC)CCC(=O)O
InChi: 1S/C19H34N2O5/c1-3-5-6-7-8-9-10-11-12-16(22)19(26)21-15(13-14-17(23)24)18(25)20-4-2/h15H,3-14H2,1-2H3,(H,20,25)(H,21,26)(H,23,24)/t15-/m1/s1
InChiKey: HSPVUUZZNCMAIZ-OAHLLOKOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tar DNA-binding protein	0.0209	0.0258	0.3689
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0089	0.0054	0.0051
Schistosoma mansoni	hypothetical protein	0.0119	0.0104	0.1462
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0089	0.0054	0.0051
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0105	0.0081	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Entamoeba histolytica	protein kinase rad3, putative	0.0262	0.0349	0.4601
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0105	0.0081	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0262	0.0349	0.4601
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0062	0.0007	0.0004
Entamoeba histolytica	hypothetical protein	0.0119	0.0104	0.078
Echinococcus granulosus	sentrin specific protease 8	0.0099	0.0071	0.0068
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0089	0.0054	0.0051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0187	0.0221	0.3144
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0187	0.022	0.3168
Trypanosoma cruzi	target of rapamycin kinase 3	0.0465	0.0695	0.1899
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0089	0.0054	0.0051
Plasmodium vivax	hypothetical protein	0.0089	0.0054	1
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.592	1	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0089	0.0054	0.0051
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0203	0.0247	0.0244
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0465	0.0695	0.1925
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0089	0.0054	0.0051
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0203	0.0248	0.3508
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0465	0.0695	0.0692
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0119	0.0104	0.0101
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0074	0.0028	0.2887
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Entamoeba histolytica	heat shock transcription factor, putative	0.0107	0.0084	0.0463
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0465	0.0695	0.1899
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0465	0.0695	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Echinococcus multilocularis		0.0089	0.0054	0.0051
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0089	0.0054	0.0132
Onchocerca volvulus		0.0108	0.0086	0.9033
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0081	0.1169
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0089	0.0054	0.0739
Brugia malayi	hypothetical protein	0.0119	0.0104	0.1412
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0036	0.0516
Leishmania major	hypothetical protein, conserved	0.2156	0.358	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0054	0.0781
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0465	0.0695	1
Echinococcus multilocularis	sentrin specific protease 7	0.0187	0.0221	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0203	0.0248	0.3574
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0036	0.0516
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0089	0.0054	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0465	0.0695	0.1925
Schistosoma mansoni	transcription factor LCR-F1	0.0119	0.0104	0.1462
Echinococcus granulosus	sentrin specific protease 7	0.0187	0.0221	0.0218
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0465	0.0695	0.0692
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0099	0.0071	0.0263
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0292	0.04	0.5399
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0465	0.0695	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0187	0.022	0.0217
Echinococcus granulosus	tumor protein p63	0.0751	0.1183	0.118
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0105	0.0081	1
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0133	0.0128	0.0338
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0305	0.0423	0.1092
Onchocerca volvulus	Heat shock factor protein 2 homolog	0.0107	0.0084	0.8474
Onchocerca volvulus		0.0105	0.0081	0.7706
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0133	0.0128	0.0218
Brugia malayi	RNA binding protein	0.0209	0.0258	0.3653
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0262	0.0349	0.4601
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0089	0.0054	0.0781
Loa Loa (eye worm)	hypothetical protein	0.0203	0.0247	0.3562
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0089	0.0054	0.0739
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0203	0.0247	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0292	0.04	0.5758
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Trypanosoma cruzi	hypothetical protein	0.0099	0.0071	0.005
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0089	0.0054	0.0739
Echinococcus multilocularis	sentrin specific protease 8	0.0099	0.0071	0.0068
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0465	0.0695	0.1899
Leishmania major	4-coumarate:coa ligase-like protein	0.0105	0.0081	0.0207
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0465	0.0695	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0262	0.0349	0.4971
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0036	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0081	0.1169
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0262	0.0349	0.4601
Entamoeba histolytica	hypothetical protein	0.0305	0.0423	0.5749
Trichomonas vaginalis	conserved hypothetical protein	0.0203	0.0247	0.3017
Loa Loa (eye worm)	phosphatidylinositol 3	0.0089	0.0054	0.0781
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0089	0.0054	0.0051
Brugia malayi	AMP-binding enzyme family protein	0.0105	0.0081	0.1078
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0089	0.0054	0.0686
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0105	0.0081	1
Trichomonas vaginalis	Sentrin-specific protease, putative	0.0099	0.0071	0.0263
Entamoeba histolytica	hypothetical protein	0.0119	0.0104	0.078
Schistosoma mansoni	cellular tumor antigen P53	0.011	0.0089	0.1245
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0105	0.0081	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0089	0.0054	0.0739
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0465	0.0695	0.0692
Schistosoma mansoni	hypothetical protein	0.0377	0.0544	0.7824
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0089	0.0054	0.0781
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0089	0.0054	0.0686
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0089	0.0054	0.6364
Schistosoma mansoni	tar DNA-binding protein	0.0209	0.0258	0.3689
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0079	0.0036	0.3875
Brugia malayi	TAR-binding protein	0.0209	0.0258	0.3653
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0074	0.0028	0.2887
Leishmania major	hypothetical protein, unknown function	0.0089	0.0054	0.0132
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0089	0.0054	0.0686
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0305	0.0423	0.5749
Mycobacterium ulcerans	hypothetical protein	0.0105	0.0081	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0105	0.0081	1
Schistosoma mansoni	tar DNA-binding protein	0.0209	0.0258	0.3689
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0262	0.0349	0.4601
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0099	0.0071	0.0263
Echinococcus granulosus	geminin	0.0377	0.0544	0.0541
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0089	0.0054	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Giardia lamblia	GTOR	0.0465	0.0695	1
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0089	0.0054	1
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0262	0.0349	0.0346
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0089	0.0054	0.0051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0089	0.0054	0.0781
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0089	0.0054	1
Loa Loa (eye worm)	RNA binding protein	0.0209	0.0258	0.3718
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0262	0.0349	0.4601
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0054	0.0781
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0089	0.0054	0.0739
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0036	0.0516
Echinococcus granulosus	tar DNA binding protein	0.0209	0.0258	0.0255
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0187	0.022	0.0217
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0105	0.0081	1
Schistosoma mansoni	tar DNA-binding protein	0.0209	0.0258	0.3689
Loa Loa (eye worm)	hypothetical protein	0.0262	0.0349	0.5023
Entamoeba histolytica	heat shock transcription factor, putative	0.0107	0.0084	0.0463
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0465	0.0695	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0262	0.0349	0.0874
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0089	0.0054	0.0686
Schistosoma mansoni	tar DNA-binding protein	0.0209	0.0258	0.3689
Echinococcus multilocularis	tar DNA binding protein	0.0209	0.0258	0.0255
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0089	0.0054	0.0051
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0465	0.0695	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0089	0.0054	0.0781
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0105	0.0081	1
Echinococcus granulosus	lysosomal alpha glucosidase	0.0187	0.022	0.0217
Trichomonas vaginalis	conserved hypothetical protein	0.0292	0.04	0.5399
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0036	0.0516
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0465	0.0695	0.0692
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0465	0.0695	0.1899
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0089	0.0054	0.0781
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0305	0.0423	0.6063
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0105	0.0081	0.0421
Schistosoma mansoni	hypothetical protein	0.0089	0.0054	0.0739
Trichomonas vaginalis	conserved hypothetical protein	0.0198	0.0239	0.2882
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0079	0.0036	0.3875
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0089	0.0054	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0262	0.0349	0.4601
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0105	0.0081	0.0421
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0292	0.04	0.5399
Loa Loa (eye worm)	phosphatidylinositol 3	0.0465	0.0695	1
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0099	0.0071	0.0931
Echinococcus granulosus	serine protein kinase ATM	0.0305	0.0423	0.042
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0089	0.0054	0.0686
Trypanosoma cruzi	hypothetical protein, conserved	0.2067	0.3427	1
Schistosoma mansoni	hypothetical protein	0.0203	0.0247	0.3533
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0089	0.0054	0.0132
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0262	0.0349	0.4601
Brugia malayi	RNA recognition motif domain containing protein	0.0209	0.0258	0.3653
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0305	0.0423	0.5749
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0079	0.0036	0.5
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0089	0.0054	0.0051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Schistosoma mansoni	hypothetical protein	0.0377	0.0544	0.7824
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.0196	0.2219
Toxoplasma gondii	FATC domain-containing protein	0.0305	0.0423	0.5749
Brugia malayi	AMP-binding enzyme family protein	0.0105	0.0081	0.1078
Loa Loa (eye worm)	TAR-binding protein	0.0209	0.0258	0.3718
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0084	0.1207
Entamoeba histolytica	hypothetical protein	0.0119	0.0104	0.078
Entamoeba histolytica	heat shock transcription factor, putative	0.0107	0.0084	0.0463
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0089	0.0054	0.0686
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0099	0.0071	0.0263
Loa Loa (eye worm)	phosphatidylinositol 3	0.0465	0.0695	1
Echinococcus granulosus	expressed conserved protein	0.0145	0.0149	0.0146
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0465	0.0695	1
Echinococcus multilocularis	tumor protein p63	0.0751	0.1183	0.118
Echinococcus multilocularis	expressed conserved protein	0.0145	0.0149	0.0146
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0089	0.0054	0.0051
Onchocerca volvulus		0.011	0.0089	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0465	0.0695	1
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0262	0.0349	0.0346
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0216	0.027	0.0639
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Echinococcus multilocularis	serine protein kinase ATM	0.0305	0.0423	0.042
Loa Loa (eye worm)	phosphatidylinositol 3	0.0089	0.0054	0.0781
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0119	0.0104	0.0101
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0209	0.0258	0.3718
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0089	0.0054	0.0051
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0089	0.0054	0.0739
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0089	0.0054	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0216	0.027	0.3885
Brugia malayi	AMP-binding enzyme family protein	0.0105	0.0081	0.1078
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0099	0.0071	0.0263
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0292	0.04	0.5399
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0099	0.0071	0.0983
Echinococcus multilocularis	geminin	0.0377	0.0544	0.0541
Mycobacterium ulcerans	acyl-CoA synthetase	0.0105	0.0081	1
Loa Loa (eye worm)	hypothetical protein	0.011	0.0089	0.1284
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.2726	0.4552	0.4551
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0187	0.022	0.3097
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0074	0.0028	0.2887
Entamoeba histolytica	hypothetical protein	0.0119	0.0104	0.078
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0465	0.0695	0.1925
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0465	0.0695	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0105	0.0081	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0105	0.0081	0.0421
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0089	0.0054	0.0686
Schistosoma mansoni	alpha-glucosidase	0.0161	0.0176	0.2496
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Plasmodium vivax	hypothetical protein, conserved	0.0089	0.0054	1
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0465	0.0695	0.1925
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.025	0.0327	0.4711
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0173	0.0196	0.2219
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0465	0.0695	0.1925
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0262	0.0349	0.5
Schistosoma mansoni	alpha-glucosidase	0.0161	0.0176	0.2496
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0081	0.1169
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0465	0.0695	0.1899
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0105	0.0081	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Leishmania major	phosphatidylinositol kinase, putative	0.0089	0.0054	0.0132
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0089	0.0054	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0305	0.0423	0.6041
Brugia malayi	follicle stimulating hormone receptor	0.025	0.0327	0.4657
Leishmania major	4-coumarate:coa ligase-like protein	0.0105	0.0081	0.0207
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0465	0.0695	1
Brugia malayi	FAT domain containing protein	0.0203	0.0247	0.3496
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0187	0.0221	0.2596
Brugia malayi	HSF-type DNA-binding domain containing protein	0.0107	0.0084	0.1117
Leishmania major	4-coumarate:coa ligase-like protein	0.0105	0.0081	0.0207
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0074	0.0028	0.2887
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Echinococcus multilocularis	Zinc finger, PHD finger	0.0089	0.0054	0.0051
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0262	0.0349	0.4601
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0062	0.0007	0.0004
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0062	0.0007	0.0057
Loa Loa (eye worm)	Ulp1 protease	0.0099	0.0071	0.1024
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0465	0.0695	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0089	0.0054	1
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0089	0.0054	0.0739
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0465	0.0695	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 12 %	Inhibition of GV sPLA2 at 0.091 mole fraction	ChEMBL.	17672443
XI50 (binding)	0	Inhibition of human GIVA cPLA2	ChEMBL.	17672443

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 432956