TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 370.484 | Formula: C19H34N2O5
H donors: 3 H acceptors: 5 LogP: 3.64 Rotable bonds: 18
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCCCCCC(=O)C(=O)N[C@H](C(=O)NCC)CCC(=O)O
InChi: 1S/C19H34N2O5/c1-3-5-6-7-8-9-10-11-12-16(22)19(26)21-15(13-14-17(23)24)18(25)20-4-2/h15H,3-14H2,1-2H3,(H,20,25)(H,21,26)(H,23,24)/t15-/m0/s1
InChiKey: HSPVUUZZNCMAIZ-HNNXBMFYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0262	0.0349	0.0346
Onchocerca volvulus		0.011	0.0089	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0465	0.0695	1
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0089	0.0054	0.0051
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0216	0.027	0.0639
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Echinococcus multilocularis	serine protein kinase ATM	0.0305	0.0423	0.042
Loa Loa (eye worm)	TAR-binding protein	0.0209	0.0258	0.3718
Brugia malayi	AMP-binding enzyme family protein	0.0105	0.0081	0.1078
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0084	0.1207
Loa Loa (eye worm)	phosphatidylinositol 3	0.0465	0.0695	1
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0099	0.0071	0.0263
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0089	0.0054	0.0686
Entamoeba histolytica	heat shock transcription factor, putative	0.0107	0.0084	0.0463
Entamoeba histolytica	hypothetical protein	0.0119	0.0104	0.078
Echinococcus multilocularis	expressed conserved protein	0.0145	0.0149	0.0146
Echinococcus multilocularis	tumor protein p63	0.0751	0.1183	0.118
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0465	0.0695	1
Echinococcus granulosus	expressed conserved protein	0.0145	0.0149	0.0146
Trichomonas vaginalis	conserved hypothetical protein	0.0173	0.0196	0.2219
Toxoplasma gondii	FATC domain-containing protein	0.0305	0.0423	0.5749
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0089	0.0054	0.0132
Schistosoma mansoni	hypothetical protein	0.0203	0.0247	0.3533
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0079	0.0036	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0209	0.0258	0.3653
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0305	0.0423	0.5749
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0262	0.0349	0.4601
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0089	0.0054	0.0051
Schistosoma mansoni	hypothetical protein	0.0377	0.0544	0.7824
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0262	0.0349	0.4601
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0105	0.0081	0.0421
Brugia malayi	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0099	0.0071	0.0931
Loa Loa (eye worm)	phosphatidylinositol 3	0.0465	0.0695	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0292	0.04	0.5399
Trypanosoma cruzi	hypothetical protein, conserved	0.2067	0.3427	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0089	0.0054	0.0686
Echinococcus granulosus	serine protein kinase ATM	0.0305	0.0423	0.042
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0036	0.0516
Trichomonas vaginalis	conserved hypothetical protein	0.0292	0.04	0.5399
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0089	0.0054	0.0781
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0465	0.0695	0.1899
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0465	0.0695	0.0692
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0305	0.0423	0.6063
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0079	0.0036	0.3875
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0089	0.0054	1
Trichomonas vaginalis	conserved hypothetical protein	0.0198	0.0239	0.2882
Schistosoma mansoni	hypothetical protein	0.0089	0.0054	0.0739
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0105	0.0081	0.0421
Schistosoma mansoni	tar DNA-binding protein	0.0209	0.0258	0.3689
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0465	0.0695	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0262	0.0349	0.0874
Entamoeba histolytica	heat shock transcription factor, putative	0.0107	0.0084	0.0463
Loa Loa (eye worm)	hypothetical protein	0.0262	0.0349	0.5023
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0465	0.0695	1
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0089	0.0054	0.0051
Schistosoma mansoni	tar DNA-binding protein	0.0209	0.0258	0.3689
Echinococcus multilocularis	tar DNA binding protein	0.0209	0.0258	0.0255
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0089	0.0054	0.0686
Echinococcus granulosus	lysosomal alpha glucosidase	0.0187	0.022	0.0217
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0105	0.0081	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0089	0.0054	0.0781
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0089	0.0054	1
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0089	0.0054	0.0781
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0262	0.0349	0.4601
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Loa Loa (eye worm)	RNA binding protein	0.0209	0.0258	0.3718
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0187	0.022	0.0217
Echinococcus granulosus	tar DNA binding protein	0.0209	0.0258	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0036	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0054	0.0781
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0089	0.0054	0.0739
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0105	0.0081	1
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0062	0.0007	0.0057
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0062	0.0007	0.0004
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0262	0.0349	0.4601
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0089	0.0054	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0465	0.0695	1
Loa Loa (eye worm)	Ulp1 protease	0.0099	0.0071	0.1024
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0089	0.0054	0.0739
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0465	0.0695	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0465	0.0695	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0105	0.0081	0.0207
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0074	0.0028	0.2887
Entamoeba histolytica	Ulp1 protease family, C-terminal catalytic domain containing protein	0.0187	0.0221	0.2596
Brugia malayi	HSF-type DNA-binding domain containing protein	0.0107	0.0084	0.1117
Brugia malayi	FAT domain containing protein	0.0203	0.0247	0.3496
Echinococcus multilocularis	Zinc finger, PHD finger	0.0089	0.0054	0.0051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Leishmania major	phosphatidylinositol kinase, putative	0.0089	0.0054	0.0132
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0089	0.0054	1
Brugia malayi	follicle stimulating hormone receptor	0.025	0.0327	0.4657
Leishmania major	4-coumarate:coa ligase-like protein	0.0105	0.0081	0.0207
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0305	0.0423	0.6041
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Schistosoma mansoni	alpha-glucosidase	0.0161	0.0176	0.2496
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0081	0.1169
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0262	0.0349	0.5
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0465	0.0695	0.1925
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0173	0.0196	0.2219
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0105	0.0081	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0465	0.0695	0.1899
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0089	0.0054	0.0686
Entamoeba histolytica	acyl-coA synthetase, putative	0.0105	0.0081	0.0421
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0465	0.0695	0.1925
Plasmodium vivax	hypothetical protein, conserved	0.0089	0.0054	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Schistosoma mansoni	alpha-glucosidase	0.0161	0.0176	0.2496
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.025	0.0327	0.4711
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.2726	0.4552	0.4551
Loa Loa (eye worm)	hypothetical protein	0.011	0.0089	0.1284
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0187	0.022	0.3097
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0465	0.0695	0.1925
Entamoeba histolytica	hypothetical protein	0.0119	0.0104	0.078
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0074	0.0028	0.2887
Mycobacterium ulcerans	acyl-CoA synthetase	0.0105	0.0081	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0465	0.0695	1
Loa Loa (eye worm)	hypothetical protein	0.0216	0.027	0.3885
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Brugia malayi	AMP-binding enzyme family protein	0.0105	0.0081	0.1078
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0099	0.0071	0.0983
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0292	0.04	0.5399
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0099	0.0071	0.0263
Mycobacterium ulcerans	acyl-CoA synthetase	0.0105	0.0081	1
Echinococcus multilocularis	geminin	0.0377	0.0544	0.0541
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0119	0.0104	0.0101
Loa Loa (eye worm)	phosphatidylinositol 3	0.0089	0.0054	0.0781
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0089	0.0054	0.0132
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0089	0.0054	0.0739
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0089	0.0054	0.0051
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0209	0.0258	0.3718
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0465	0.0695	0.0692
Echinococcus granulosus	sentrin specific protease 7	0.0187	0.0221	0.0218
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0465	0.0695	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0292	0.04	0.5399
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0099	0.0071	0.0263
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0133	0.0128	0.0338
Echinococcus granulosus	tumor protein p63	0.0751	0.1183	0.118
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0105	0.0081	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0187	0.022	0.0217
Onchocerca volvulus		0.0105	0.0081	0.7706
Onchocerca volvulus	Heat shock factor protein 2 homolog	0.0107	0.0084	0.8474
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0305	0.0423	0.1092
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0089	0.0054	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0036	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0203	0.0248	0.3574
Schistosoma mansoni	transcription factor LCR-F1	0.0119	0.0104	0.1462
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0465	0.0695	0.1925
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Leishmania major	hypothetical protein, conserved	0.2156	0.358	1
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0036	0.0516
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Echinococcus multilocularis	sentrin specific protease 7	0.0187	0.0221	0.0218
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0465	0.0695	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0054	0.0781
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0465	0.0695	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0081	0.1169
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0089	0.0054	0.0132
Echinococcus multilocularis		0.0089	0.0054	0.0051
Onchocerca volvulus		0.0108	0.0086	0.9033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Brugia malayi	hypothetical protein	0.0119	0.0104	0.1412
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0089	0.0054	0.0739
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0465	0.0695	0.1925
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0119	0.0104	0.0101
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0074	0.0028	0.2887
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0089	0.0054	0.0051
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0465	0.0695	0.0692
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0203	0.0248	0.3508
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0465	0.0695	0.1899
Entamoeba histolytica	heat shock transcription factor, putative	0.0107	0.0084	0.0463
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0187	0.022	0.3168
Schistosoma mansoni	family C48 unassigned peptidase (C48 family)	0.0187	0.0221	0.3144
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0089	0.0054	0.0051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.0465	0.0695	0.1899
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0089	0.0054	0.0051
Plasmodium vivax	hypothetical protein	0.0089	0.0054	1
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.592	1	1
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0203	0.0247	0.0244
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Entamoeba histolytica	hypothetical protein	0.0119	0.0104	0.078
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0062	0.0007	0.0004
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0089	0.0054	0.0051
Echinococcus granulosus	sentrin specific protease 8	0.0099	0.0071	0.0068
Schistosoma mansoni	hypothetical protein	0.0119	0.0104	0.1462
Schistosoma mansoni	tar DNA-binding protein	0.0209	0.0258	0.3689
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0089	0.0054	0.0051
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0089	0.0054	0.0051
Entamoeba histolytica	protein kinase rad3, putative	0.0262	0.0349	0.4601
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0105	0.0081	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0262	0.0349	0.4601
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0105	0.0081	1
Giardia lamblia	GTOR	0.0465	0.0695	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0089	0.0054	1
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0089	0.0054	1
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0262	0.0349	0.0346
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0089	0.0054	0.0051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0089	0.0054	0.0686
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0105	0.0081	1
Schistosoma mansoni	tar DNA-binding protein	0.0209	0.0258	0.3689
Mycobacterium ulcerans	hypothetical protein	0.0105	0.0081	1
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0305	0.0423	0.5749
Echinococcus granulosus	geminin	0.0377	0.0544	0.0541
Trichomonas vaginalis	Clan CE, family C48, Ulp1-like cysteine peptidase	0.0099	0.0071	0.0263
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0262	0.0349	0.4601
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Schistosoma mansoni	hypothetical protein	0.0377	0.0544	0.7824
Loa Loa (eye worm)	phosphatidylinositol 3	0.0089	0.0054	0.0781
Schistosoma mansoni	tar DNA-binding protein	0.0209	0.0258	0.3689
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0089	0.0054	0.6364
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0089	0.0054	0.0686
Brugia malayi	TAR-binding protein	0.0209	0.0258	0.3653
Leishmania major	hypothetical protein, unknown function	0.0089	0.0054	0.0132
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0074	0.0028	0.2887
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0079	0.0036	0.3875
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0105	0.0081	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Schistosoma mansoni	cellular tumor antigen P53	0.011	0.0089	0.1245
Entamoeba histolytica	hypothetical protein	0.0119	0.0104	0.078
Trichomonas vaginalis	Sentrin-specific protease, putative	0.0099	0.0071	0.0263
Mycobacterium ulcerans	acyl-CoA synthetase	0.0105	0.0081	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0465	0.0695	0.0692
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0089	0.0054	0.0739
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0089	0.0054	0.0051
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0089	0.0054	0.0686
Brugia malayi	AMP-binding enzyme family protein	0.0105	0.0081	0.1078
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0036	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0081	0.1169
Entamoeba histolytica	hypothetical protein	0.0305	0.0423	0.5749
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0262	0.0349	0.4601
Loa Loa (eye worm)	phosphatidylinositol 3	0.0089	0.0054	0.0781
Trichomonas vaginalis	conserved hypothetical protein	0.0203	0.0247	0.3017
Echinococcus multilocularis	sentrin specific protease 8	0.0099	0.0071	0.0068
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0089	0.0054	0.0739
Trypanosoma cruzi	hypothetical protein	0.0099	0.0071	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0105	0.0081	0.0207
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0465	0.0695	0.1899
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0262	0.0349	0.4971
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0465	0.0695	1
Brugia malayi	RNA binding protein	0.0209	0.0258	0.3653
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0133	0.0128	0.0218
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0262	0.0349	0.4601
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0465	0.0695	1
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0203	0.0247	0.0244
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0089	0.0054	0.0739
Loa Loa (eye worm)	hypothetical protein	0.0203	0.0247	0.3562
Loa Loa (eye worm)	phosphatidylinositol 3	0.0089	0.0054	0.0781
Loa Loa (eye worm)	hypothetical protein	0.0292	0.04	0.5758

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 30 %	Inhibition of GV sPLA2 at 0.091 mole fraction	ChEMBL.	17672443
XI50 (binding)	0	Inhibition of human GIVA cPLA2	ChEMBL.	17672443

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 432958