Detailed information for compound 432962

Basic information

Technical information
  • TDR Targets ID: 432962
  • Name: (4S)-5-(decylamino)-5-oxo-4-(2-oxohexadecanoy lamino)pentanoic acid
  • MW: 538.803 | Formula: C31H58N2O5
  • H donors: 3 H acceptors: 5 LogP: 9.94 Rotable bonds: 30
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCCCCCCCC(=O)C(=O)N[C@H](C(=O)NCCCCCCCCCC)CCC(=O)O
  • InChi: 1S/C31H58N2O5/c1-3-5-7-9-11-13-14-15-16-17-19-21-23-28(34)31(38)33-27(24-25-29(35)36)30(37)32-26-22-20-18-12-10-8-6-4-2/h27H,3-26H2,1-2H3,(H,32,37)(H,33,38)(H,35,36)/t27-/m0/s1
  • InChiKey: CSDAMUIBAFBAMB-MHZLTWQESA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4S)-5-(decylamino)-4-(1,2-dioxohexadecylamino)-5-oxopentanoic acid
  • (4S)-5-(decylamino)-5-keto-4-(2-ketohexadecanoylamino)valeric acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) follicle stimulating hormone receptor 0.025 0.0327 0.4711
Schistosoma mansoni alpha-glucosidase 0.0161 0.0176 0.2496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0465 0.0695 0.1925
Plasmodium vivax hypothetical protein, conserved 0.0089 0.0054 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0105 0.0081 0.0421
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0089 0.0054 0.0686
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0465 0.0695 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0105 0.0081 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0028 0.2887
Entamoeba histolytica hypothetical protein 0.0119 0.0104 0.078
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0465 0.0695 0.1925
Brugia malayi Glycosyl hydrolases family 31 protein 0.0187 0.022 0.3097
Loa Loa (eye worm) hypothetical protein 0.011 0.0089 0.1284
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2726 0.4552 0.4551
Echinococcus multilocularis geminin 0.0377 0.0544 0.0541
Mycobacterium ulcerans acyl-CoA synthetase 0.0105 0.0081 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0099 0.0071 0.0263
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0099 0.0071 0.0983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0292 0.04 0.5399
Brugia malayi AMP-binding enzyme family protein 0.0105 0.0081 0.1078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Loa Loa (eye worm) hypothetical protein 0.0216 0.027 0.3885
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0209 0.0258 0.3718
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0089 0.0054 0.0051
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0089 0.0054 0.0739
Leishmania major phosphatidylinositol 4-kinase, putative 0.0089 0.0054 0.0132
Loa Loa (eye worm) phosphatidylinositol 3 0.0089 0.0054 0.0781
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0119 0.0104 0.0101
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0465 0.0695 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0089 0.0054 0.0739
Loa Loa (eye worm) Ulp1 protease 0.0099 0.0071 0.1024
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0465 0.0695 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0089 0.0054 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0262 0.0349 0.4601
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.0007 0.0057
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0007 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0089 0.0054 0.0051
Brugia malayi FAT domain containing protein 0.0203 0.0247 0.3496
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0187 0.0221 0.2596
Brugia malayi HSF-type DNA-binding domain containing protein 0.0107 0.0084 0.1117
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0028 0.2887
Leishmania major 4-coumarate:coa ligase-like protein 0.0105 0.0081 0.0207
Toxoplasma gondii target of rapamycin (TOR), putative 0.0465 0.0695 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0305 0.0423 0.6041
Brugia malayi follicle stimulating hormone receptor 0.025 0.0327 0.4657
Leishmania major 4-coumarate:coa ligase-like protein 0.0105 0.0081 0.0207
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0089 0.0054 1
Leishmania major phosphatidylinositol kinase, putative 0.0089 0.0054 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0465 0.0695 0.1899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0105 0.0081 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.0196 0.2219
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0465 0.0695 0.1925
Schistosoma mansoni fkbp-rapamycin associated protein 0.0262 0.0349 0.5
Schistosoma mansoni alpha-glucosidase 0.0161 0.0176 0.2496
Loa Loa (eye worm) hypothetical protein 0.0105 0.0081 0.1169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Echinococcus granulosus serine protein kinase ATM 0.0305 0.0423 0.042
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0089 0.0054 0.0686
Trypanosoma cruzi hypothetical protein, conserved 0.2067 0.3427 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0292 0.04 0.5399
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0099 0.0071 0.0931
Loa Loa (eye worm) phosphatidylinositol 3 0.0465 0.0695 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0105 0.0081 0.0421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0262 0.0349 0.4601
Entamoeba histolytica acyl-CoA synthetase, putative 0.0105 0.0081 0.0421
Schistosoma mansoni hypothetical protein 0.0089 0.0054 0.0739
Trichomonas vaginalis conserved hypothetical protein 0.0198 0.0239 0.2882
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0089 0.0054 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0079 0.0036 0.3875
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0305 0.0423 0.6063
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0465 0.0695 0.0692
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0465 0.0695 0.1899
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0089 0.0054 0.0781
Trichomonas vaginalis conserved hypothetical protein 0.0292 0.04 0.5399
Loa Loa (eye worm) hypothetical protein 0.0079 0.0036 0.0516
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0105 0.0081 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0089 0.0054 0.0781
Echinococcus granulosus lysosomal alpha glucosidase 0.0187 0.022 0.0217
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0089 0.0054 0.0686
Echinococcus multilocularis tar DNA binding protein 0.0209 0.0258 0.0255
Schistosoma mansoni tar DNA-binding protein 0.0209 0.0258 0.3689
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0089 0.0054 0.0051
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0465 0.0695 1
Loa Loa (eye worm) hypothetical protein 0.0262 0.0349 0.5023
Entamoeba histolytica heat shock transcription factor, putative 0.0107 0.0084 0.0463
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0262 0.0349 0.0874
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0465 0.0695 1
Schistosoma mansoni tar DNA-binding protein 0.0209 0.0258 0.3689
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0105 0.0081 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0089 0.0054 0.0739
Loa Loa (eye worm) hypothetical protein 0.0089 0.0054 0.0781
Loa Loa (eye worm) hypothetical protein 0.0079 0.0036 0.0516
Echinococcus granulosus tar DNA binding protein 0.0209 0.0258 0.0255
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.022 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Loa Loa (eye worm) RNA binding protein 0.0209 0.0258 0.3718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0262 0.0349 0.4601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Loa Loa (eye worm) phosphatidylinositol kinase 0.0089 0.0054 0.0781
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0089 0.0054 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Echinococcus multilocularis serine protein kinase ATM 0.0305 0.0423 0.042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0216 0.027 0.0639
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0089 0.0054 0.0051
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0465 0.0695 1
Onchocerca volvulus 0.011 0.0089 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0262 0.0349 0.0346
Echinococcus granulosus expressed conserved protein 0.0145 0.0149 0.0146
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0465 0.0695 1
Echinococcus multilocularis expressed conserved protein 0.0145 0.0149 0.0146
Echinococcus multilocularis tumor protein p63 0.0751 0.1183 0.118
Entamoeba histolytica hypothetical protein 0.0119 0.0104 0.078
Entamoeba histolytica heat shock transcription factor, putative 0.0107 0.0084 0.0463
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0099 0.0071 0.0263
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0089 0.0054 0.0686
Loa Loa (eye worm) phosphatidylinositol 3 0.0465 0.0695 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0084 0.1207
Brugia malayi AMP-binding enzyme family protein 0.0105 0.0081 0.1078
Loa Loa (eye worm) TAR-binding protein 0.0209 0.0258 0.3718
Toxoplasma gondii FATC domain-containing protein 0.0305 0.0423 0.5749
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.0196 0.2219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Schistosoma mansoni hypothetical protein 0.0377 0.0544 0.7824
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0089 0.0054 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0262 0.0349 0.4601
Brugia malayi RNA recognition motif domain containing protein 0.0209 0.0258 0.3653
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.0423 0.5749
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0079 0.0036 0.5
Schistosoma mansoni hypothetical protein 0.0203 0.0247 0.3533
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0089 0.0054 0.0132
Brugia malayi AMP-binding enzyme family protein 0.0105 0.0081 0.1078
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0089 0.0054 0.0686
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0089 0.0054 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.0247 0.3017
Loa Loa (eye worm) phosphatidylinositol 3 0.0089 0.0054 0.0781
Trichomonas vaginalis PIKK family atypical protein kinase 0.0262 0.0349 0.4601
Entamoeba histolytica hypothetical protein 0.0305 0.0423 0.5749
Loa Loa (eye worm) hypothetical protein 0.0105 0.0081 0.1169
Loa Loa (eye worm) hypothetical protein 0.0079 0.0036 0.0516
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0465 0.0695 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0262 0.0349 0.4971
Leishmania major 4-coumarate:coa ligase-like protein 0.0105 0.0081 0.0207
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0465 0.0695 0.1899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Trypanosoma cruzi hypothetical protein 0.0099 0.0071 0.005
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0089 0.0054 0.0739
Echinococcus multilocularis sentrin specific protease 8 0.0099 0.0071 0.0068
Loa Loa (eye worm) hypothetical protein 0.0292 0.04 0.5758
Loa Loa (eye worm) phosphatidylinositol 3 0.0089 0.0054 0.0781
Loa Loa (eye worm) hypothetical protein 0.0203 0.0247 0.3562
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0089 0.0054 0.0739
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0203 0.0247 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0262 0.0349 0.4601
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0133 0.0128 0.0218
Brugia malayi RNA binding protein 0.0209 0.0258 0.3653
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0089 0.0054 0.0051
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0262 0.0349 0.0346
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0089 0.0054 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0089 0.0054 1
Giardia lamblia GTOR 0.0465 0.0695 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0262 0.0349 0.4601
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0099 0.0071 0.0263
Echinococcus granulosus geminin 0.0377 0.0544 0.0541
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0305 0.0423 0.5749
Mycobacterium ulcerans hypothetical protein 0.0105 0.0081 1
Schistosoma mansoni tar DNA-binding protein 0.0209 0.0258 0.3689
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0105 0.0081 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0089 0.0054 0.0686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0079 0.0036 0.3875
Leishmania major hypothetical protein, unknown function 0.0089 0.0054 0.0132
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0028 0.2887
Brugia malayi TAR-binding protein 0.0209 0.0258 0.3653
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0089 0.0054 0.0686
Mycobacterium tuberculosis Conserved hypothetical protein 0.0089 0.0054 0.6364
Schistosoma mansoni tar DNA-binding protein 0.0209 0.0258 0.3689
Loa Loa (eye worm) phosphatidylinositol 3 0.0089 0.0054 0.0781
Schistosoma mansoni hypothetical protein 0.0377 0.0544 0.7824
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0089 0.0054 0.0739
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0465 0.0695 0.0692
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0105 0.0081 1
Trichomonas vaginalis Sentrin-specific protease, putative 0.0099 0.0071 0.0263
Schistosoma mansoni cellular tumor antigen P53 0.011 0.0089 0.1245
Entamoeba histolytica hypothetical protein 0.0119 0.0104 0.078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0105 0.0081 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Entamoeba histolytica heat shock transcription factor, putative 0.0107 0.0084 0.0463
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0465 0.0695 0.1899
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0203 0.0248 0.3508
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0089 0.0054 0.0051
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0465 0.0695 0.0692
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0119 0.0104 0.0101
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0028 0.2887
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0465 0.0695 0.1925
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0203 0.0247 0.0244
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.592 1 1
Plasmodium vivax hypothetical protein 0.0089 0.0054 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0089 0.0054 0.0051
Trypanosoma cruzi target of rapamycin kinase 3 0.0465 0.0695 0.1899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0089 0.0054 0.0051
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0187 0.0221 0.3144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0187 0.022 0.3168
Echinococcus granulosus sentrin specific protease 8 0.0099 0.0071 0.0068
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0089 0.0054 0.0051
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0007 0.0004
Entamoeba histolytica hypothetical protein 0.0119 0.0104 0.078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0105 0.0081 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0262 0.0349 0.4601
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0105 0.0081 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Entamoeba histolytica protein kinase rad3, putative 0.0262 0.0349 0.4601
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0089 0.0054 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0209 0.0258 0.3689
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0089 0.0054 0.0051
Schistosoma mansoni hypothetical protein 0.0119 0.0104 0.1462
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0305 0.0423 0.1092
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0107 0.0084 0.8474
Onchocerca volvulus 0.0105 0.0081 0.7706
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0105 0.0081 1
Echinococcus granulosus tumor protein p63 0.0751 0.1183 0.118
Echinococcus multilocularis lysosomal alpha glucosidase 0.0187 0.022 0.0217
Leishmania major phosphatidylinositol kinase related protein, putative 0.0133 0.0128 0.0338
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0099 0.0071 0.0263
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0292 0.04 0.5399
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0465 0.0695 1
Echinococcus granulosus sentrin specific protease 7 0.0187 0.0221 0.0218
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0465 0.0695 0.0692
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0465 0.0695 0.1925
Schistosoma mansoni transcription factor LCR-F1 0.0119 0.0104 0.1462
Loa Loa (eye worm) hypothetical protein 0.0203 0.0248 0.3574
Loa Loa (eye worm) hypothetical protein 0.0079 0.0036 0.0516
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0089 0.0054 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0054 0.0781
Echinococcus multilocularis sentrin specific protease 7 0.0187 0.0221 0.0218
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0465 0.0695 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0036 0.0516
Leishmania major hypothetical protein, conserved 0.2156 0.358 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0089 0.0054 0.0739
Brugia malayi hypothetical protein 0.0119 0.0104 0.1412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0465 0.0695 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0089 0.0054 0.0132
Echinococcus multilocularis 0.0089 0.0054 0.0051
Loa Loa (eye worm) hypothetical protein 0.0105 0.0081 0.1169
Onchocerca volvulus 0.0108 0.0086 0.9033
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0465 0.0695 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 11 % Analgesic activity in rat assessed as decrease in writhes at 0.0165 mmol/kg, ip ChEMBL. 17672443
ED50 (functional) = 0.0165 mmol/Kg Antiinflammatory activity against carrageenan-induced paw edema in rat ChEMBL. 17672443
Inhibition (binding) = 33 % Inhibition of GV sPLA2 at 0.091 mole fraction ChEMBL. 17672443
XI50 (binding) = 0.025 Inhibition of human GIVA cPLA2 ChEMBL. 17672443

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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