Detailed information for compound 445177

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 412.54 | Formula: C25H33FN2O2
  • H donors: 0 H acceptors: 0 LogP: 4.48 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)[C@@H]1CN(C)Cc2c1ccc(c2)OCCCN1CCC(CC1)F
  • InChi: 1S/C25H33FN2O2/c1-27-17-20-16-23(30-15-3-12-28-13-10-21(26)11-14-28)8-9-24(20)25(18-27)19-4-6-22(29-2)7-5-19/h4-9,16,21,25H,3,10-15,17-18H2,1-2H3/t25-/m0/s1
  • InChiKey: AHOJZWPBIHIALS-VWLOTQADSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H3 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0158 0.1624 0.242
Schistosoma mansoni neuropeptide receptor 0.0158 0.1624 0.2397
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0113 0.109 0.1598
Trypanosoma brucei heat shock protein, putative 0.0594 0.6712 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0025 0.0066 0.0046
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0099
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0066 0.0069
Brugia malayi Probable DNA topoisomerase II 0.0113 0.109 0.1598
Loa Loa (eye worm) serotonin transporter b 0.0146 0.1481 0.2206
Echinococcus multilocularis G-protein coupled receptor, putative 0.0158 0.1624 0.1607
Mycobacterium tuberculosis Possible oxidoreductase 0.0534 0.6004 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0113 0.109 0.1598
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0066 0.0069
Trypanosoma cruzi Heat shock protein 83, putative 0.0594 0.6712 1
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.049 0.5494 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0113 0.109 0.1072
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0158 0.1624 0.242
Echinococcus multilocularis neuropeptide Y receptor 0.0158 0.1624 0.1607
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Schistosoma mansoni hypothetical protein 0.0158 0.1624 0.2397
Mycobacterium tuberculosis Conserved hypothetical protein 0.0198 0.2084 0.3448
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0113 0.109 0.1598
Schistosoma mansoni pyruvate dehydrogenase 0.0113 0.109 0.1598
Brugia malayi hypothetical protein 0.0158 0.1624 0.2397
Trypanosoma brucei heat shock protein, putative 0.0594 0.6712 1
Schistosoma mansoni amine GPCR 0.0158 0.1624 0.2397
Loa Loa (eye worm) hypothetical protein 0.0044 0.0291 0.0433
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Trypanosoma cruzi DNA topoisomerase II, putative 0.0113 0.109 0.1598
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0158 0.1624 0.1607
Echinococcus granulosus alpha 1A adrenergic receptor 0.0158 0.1624 0.2397
Schistosoma mansoni hypothetical protein 0.0158 0.1624 0.2397
Brugia malayi hypothetical protein 0.0158 0.1624 0.2397
Trichomonas vaginalis receptor histidine kinase, putative 0.0113 0.109 0.1598
Echinococcus granulosus biogenic amine 5HT receptor 0.0158 0.1624 0.2397
Loa Loa (eye worm) hypothetical protein 0.0076 0.0669 0.0997
Mycobacterium ulcerans two component sensor kinase MprB 0.0113 0.109 0.1787
Echinococcus multilocularis neuropeptide FF receptor 2 0.0158 0.1624 0.1607
Leishmania major heat shock protein, putative 0.031 0.3399 0.505
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1624 0.1607
Brugia malayi Tachykinin-like peptides receptor 99D 0.0158 0.1624 0.2397
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Brugia malayi putative neuropeptide receptor 0.0158 0.1624 0.2397
Brugia malayi follicle stimulating hormone receptor 0.0158 0.1624 0.2397
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0099
Echinococcus multilocularis serotonin receptor 0.0158 0.1624 0.1607
Onchocerca volvulus 0.0158 0.1624 0.4674
Trichomonas vaginalis heat shock protein, putative 0.0367 0.4063 0.6042
Schistosoma mansoni heat shock protein 0.031 0.3399 0.505
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Plasmodium vivax heat shock protein 90, putative 0.031 0.3399 0.5016
Leishmania major mitochondrial DNA topoisomerase II 0.0113 0.109 0.1598
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0263 0.2845 0.4221
Schistosoma mansoni neuropeptide receptor 0.0158 0.1624 0.2397
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.023 0.021
Brugia malayi hypothetical protein 0.0025 0.0066 0.0069
Schistosoma mansoni biogenic amine receptor 0.0158 0.1624 0.2397
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0158 0.1624 0.2397
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0113 0.109 0.1598
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0099
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Loa Loa (eye worm) hypothetical protein 0.0113 0.109 0.1624
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus granulosus biogenic amine 5HT receptor 0.0158 0.1624 0.2397
Wolbachia endosymbiont of Brugia malayi 2-nitropropane dioxygenase 0.0198 0.2084 0.2022
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Giardia lamblia Heat shock protein HSP 90-alpha 0.0594 0.6712 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0158 0.1624 0.2397
Trichomonas vaginalis heat shock protein, putative 0.0594 0.6712 1
Leishmania major heat shock protein 83-1 0.0594 0.6712 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0146 0.1481 0.2182
Trypanosoma brucei heat shock protein, putative 0.0594 0.6712 1
Echinococcus multilocularis neuropeptide receptor A26 0.0158 0.1624 0.1607
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0066 0.0069
Trichomonas vaginalis heat shock protein, putative 0.049 0.5494 0.818
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0113 0.109 0.1787
Schistosoma mansoni amine GPCR 0.0158 0.1624 0.2397
Treponema pallidum sodium- and chloride- dependent transporter 0.0146 0.1481 0.0887
Leishmania major developmentally regulated phosphoprotein-like protein 0.0113 0.109 0.1598
Echinococcus granulosus peptide allatostatin:somatostatin 0.0158 0.1624 0.2397
Onchocerca volvulus 0.0158 0.1624 0.4674
Echinococcus granulosus somatostatin receptor 0.0158 0.1624 0.2397
Brugia malayi G protein-coupled receptor 0.0158 0.1624 0.2397
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0158 0.1624 0.242
Trichomonas vaginalis receptor histidine kinase, putative 0.0113 0.109 0.1598
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1624 0.2397
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0095 0.0111
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0158 0.1624 0.1607
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0354 0.0498
Schistosoma mansoni amine GPCR 0.0158 0.1624 0.2397
Plasmodium falciparum heat shock protein 90, putative 0.0263 0.2845 0.4182
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Trypanosoma brucei heat shock protein, putative 0.0594 0.6712 1
Echinococcus granulosus neuropeptide Y receptor 0.0158 0.1624 0.2397
Brugia malayi kinase, mitochondrial precursor 0.0113 0.109 0.1598
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0113 0.109 0.1787
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Brugia malayi Serotonin receptor 0.0158 0.1624 0.2397
Brugia malayi hypothetical protein 0.0158 0.1624 0.2397
Leishmania major heat shock protein 83-1 0.0594 0.6712 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0158 0.1624 0.1607
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0025 0.0066 0.0069
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0158 0.1624 0.2397
Onchocerca volvulus 0.0158 0.1624 0.4674
Echinococcus granulosus neuropeptide FF receptor 2 0.0158 0.1624 0.2397
Mycobacterium ulcerans DNA gyrase subunit B 0.0113 0.109 0.1787
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0482 0.5399 0.8038
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0113 0.109 0.1598
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0061 0.0061
Plasmodium falciparum DNA topoisomerase 2 0.0113 0.109 0.154
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0037 0.0056
Brugia malayi GnHR receptor homolog 0.0158 0.1624 0.2397
Chlamydia trachomatis DNA gyrase subunit B 0.0113 0.109 1
Plasmodium vivax hypothetical protein, conserved 0.0113 0.109 0.154
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0158 0.1624 0.2397
Leishmania major heat shock protein 83-1 0.0594 0.6712 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Giardia lamblia Grp94/Hsp90 0.049 0.5494 0.818
Brugia malayi hypothetical protein 0.0158 0.1624 0.2397
Trypanosoma cruzi heat shock protein 85, putative 0.0482 0.5399 0.8038
Plasmodium vivax heat shock protein, putative 0.0263 0.2845 0.4182
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0113 0.109 0.1598
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus granulosus g protein coupled receptor 0.0158 0.1624 0.2397
Plasmodium vivax heat shock protein 86, putative 0.0594 0.6712 1
Schistosoma mansoni hypothetical protein 0.0022 0.0037 0.0025
Schistosoma mansoni alpha-1 adrenergic receptor 0.0158 0.1624 0.2397
Echinococcus granulosus g protein coupled receptor 0.0158 0.1624 0.2397
Onchocerca volvulus 0.0158 0.1624 0.4674
Echinococcus granulosus 7tm_1 domain containing protein 0.0158 0.1624 0.2397
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0158 0.1624 0.1607
Mycobacterium ulcerans heat shock protein 90 0.049 0.5494 0.9146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1624 0.2397
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Trypanosoma brucei heat shock protein, putative 0.0594 0.6712 1
Loa Loa (eye worm) G-protein coupled receptor 0.0158 0.1624 0.242
Echinococcus granulosus neuropeptide receptor 0.0158 0.1624 0.2397
Brugia malayi PHD-finger family protein 0.0027 0.0091 0.0106
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0095 0.0043
Leishmania major heat shock protein 83-1 0.0594 0.6712 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1481 0.2206
Schistosoma mansoni neuropeptide F-like receptor 0.0158 0.1624 0.2397
Trypanosoma cruzi heat shock protein 85, putative 0.0594 0.6712 1
Echinococcus multilocularis neuropeptide Y receptor 0.0158 0.1624 0.1607
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.031 0.3399 0.505
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Brugia malayi G-protein coupled receptor 0.0158 0.1624 0.2397
Echinococcus granulosus zinc finger protein 0.0021 0.0024 0.0005
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0113 0.109 0.154
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Schistosoma mansoni adenoreceptor 0.0158 0.1624 0.2397
Loa Loa (eye worm) melatonin receptor type 1A 0.0158 0.1624 0.242
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus multilocularis fmrfamide receptor 0.0158 0.1624 0.1607
Brugia malayi G-protein coupled receptor 0.0158 0.1624 0.2397
Echinococcus multilocularis dro:myosuppressin receptor 0.0158 0.1624 0.1607
Mycobacterium tuberculosis Possible two component sensor kinase 0.0113 0.109 0.1787
Onchocerca volvulus 0.0158 0.1624 0.4674
Echinococcus multilocularis allatostatin A receptor 0.0158 0.1624 0.1607
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0113 0.109 0.3071
Onchocerca volvulus 0.0158 0.1624 0.4674
Schistosoma mansoni sodium/chloride dependent transporter 0.0025 0.0066 0.0069
Onchocerca volvulus 0.0158 0.1624 0.4674
Entamoeba histolytica DNA topoisomerase II, putative 0.0113 0.109 0.1598
Mycobacterium tuberculosis Conserved hypothetical protein 0.0198 0.2084 0.3448
Leishmania major hypothetical protein, conserved 0.0113 0.109 0.1598
Echinococcus granulosus neuropeptide Y receptor 0.0158 0.1624 0.2397
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1624 0.2397
Brugia malayi hypothetical protein 0.0158 0.1624 0.2397
Mycobacterium tuberculosis Conserved protein 0.0198 0.2084 0.3448
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0113 0.109 0.1787
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.031 0.3399 1
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0113 0.109 0.1787
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1624 0.2397
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1624 0.1607
Brugia malayi larval opioid receptor 0.0158 0.1624 0.2397
Toxoplasma gondii heat shock protein HSP90 0.0594 0.6712 1
Echinococcus multilocularis fmrfamide receptor 0.0158 0.1624 0.1607
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0099
Loa Loa (eye worm) hypothetical protein 0.0113 0.109 0.1624
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0113 0.109 0.1787
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0146 0.1481 0.2182
Schistosoma mansoni biogenic amine (5HT) receptor 0.0158 0.1624 0.2397
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0113 0.109 0.1787
Loa Loa (eye worm) neuropeptide F receptor 0.0158 0.1624 0.242
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0158 0.1624 0.2397
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.031 0.3399 0.3386
Echinococcus multilocularis zinc finger protein 0.0021 0.0024 0.0004
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0113 0.109 0.3071
Echinococcus multilocularis endoplasmin 0.049 0.5494 0.5484
Giardia lamblia Heat shock protein HSP 90-alpha 0.0482 0.5399 0.8038
Brugia malayi Hsp90 protein 0.031 0.3399 0.505
Toxoplasma gondii heat shock protein 75, putative 0.031 0.3399 0.5016
Leishmania major heat shock protein 83-1 0.0594 0.6712 1
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0113 0.109 0.1598
Echinococcus granulosus orexin receptor type 2 0.0158 0.1624 0.2397
Echinococcus granulosus G protein coupled receptor 139 0.0158 0.1624 0.2397
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1624 0.2397
Echinococcus multilocularis serotonin transporter 0.0146 0.1481 0.1463
Echinococcus multilocularis g protein coupled receptor 0.0158 0.1624 0.1607
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0061 0.0041
Loa Loa (eye worm) solute carrier family 6 member 4 0.0146 0.1481 0.2206
Echinococcus multilocularis somatostatin receptor 0.0158 0.1624 0.1607
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0354 0.0334
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Brugia malayi G protein-coupled receptor F59B2.13 0.0158 0.1624 0.2397
Echinococcus multilocularis heat shock protein 90 0.0482 0.5399 0.5389
Trypanosoma brucei heat shock protein, putative 0.0594 0.6712 1
Schistosoma mansoni hypothetical protein 0.0563 0.6342 0.9447
Echinococcus granulosus neuropeptide receptor A26 0.0158 0.1624 0.2397
Giardia lamblia Pms1-like protein 0.0113 0.109 0.1598
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1624 0.1607
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.023 0.0313
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0025 0.0066 0.0046
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0113 0.109 0.1598
Schistosoma mansoni hypothetical protein 0.0158 0.1624 0.2397
Brugia malayi Dopamine receptor protein 1 0.0158 0.1624 0.2397
Loa Loa (eye worm) TOPoisomerase family member 0.0113 0.109 0.1624
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0158 0.1624 0.2397
Schistosoma mansoni opsin-like receptor 0.0158 0.1624 0.2397
Loa Loa (eye worm) heat shock protein 90 0.0594 0.6712 1
Mycobacterium ulcerans putative regultory protein 0.0113 0.109 0.1787
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Brugia malayi Serotonin receptor 0.0158 0.1624 0.2397
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0113 0.109 0.1598
Echinococcus multilocularis g protein coupled receptor 0.0158 0.1624 0.1607
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0113 0.109 0.1072
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0025 0.0066 0.0046
Plasmodium falciparum heat shock protein 90, putative 0.0302 0.3305 0.4873
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0066 0.0099
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0158 0.1624 0.2397
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0158 0.1624 0.1607
Loa Loa (eye worm) G-protein coupled receptor 0.0158 0.1624 0.242
Brugia malayi Bromodomain containing protein 0.0041 0.026 0.0358
Schistosoma mansoni biogenic amine receptor 0.0158 0.1624 0.2397
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1624 0.1607
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0099
Onchocerca volvulus 0.0158 0.1624 0.4674
Schistosoma mansoni bromodomain containing protein 0.0068 0.0575 0.0829
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0113 0.109 0.1598
Trypanosoma cruzi heat shock protein 85, putative 0.0594 0.6712 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0113 0.109 0.1598
Schistosoma mansoni myosin xvIII 0.0158 0.1624 0.2397
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Schistosoma mansoni amine GPCR 0.0158 0.1624 0.2397
Trypanosoma brucei heat shock protein 90, putative 0.0594 0.6712 1
Echinococcus granulosus neuropeptides capa receptor 0.0158 0.1624 0.2397
Mycobacterium tuberculosis Possible alanine rich oxidoreductase 0.0534 0.6004 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.049 0.5494 0.818
Schistosoma mansoni hypothetical protein 0.0158 0.1624 0.2397
Leishmania major heat shock protein 83-1 0.0594 0.6712 1
Echinococcus multilocularis neuropeptide receptor 0.0158 0.1624 0.1607
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0066 0.0069
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus granulosus sex peptide receptor 0.0158 0.1624 0.2397
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0113 0.109 0.1787
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0066 0.0069
Onchocerca volvulus 0.0158 0.1624 0.4674
Onchocerca volvulus 0.0158 0.1624 0.4674
Brugia malayi AKH receptor 0.0158 0.1624 0.2397
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0158 0.1624 0.242
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1624 0.2397
Echinococcus multilocularis G protein coupled receptor 139 0.0158 0.1624 0.1607
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1624 0.2397
Leishmania major DNA topoisomerase ii 0.0113 0.109 0.1598
Loa Loa (eye worm) hypothetical protein 0.0146 0.1481 0.2206
Echinococcus granulosus serotonin transporter 0.0146 0.1481 0.2182
Leishmania major enoyl-[acyl-carrier-protein] reductase, putative 0.0534 0.6004 0.8943
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0158 0.1624 0.4674
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Schistosoma mansoni neuropeptide receptor 0.0158 0.1624 0.2397
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1624 0.2397
Loa Loa (eye worm) endoplasmin 0.0594 0.6712 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0158 0.1624 0.2397
Echinococcus granulosus dro:myosuppressin receptor 0.0158 0.1624 0.2397
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1624 0.2397
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0113 0.109 0.3071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1624 0.1607
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0066 0.0046
Echinococcus multilocularis g protein coupled receptor 0.0158 0.1624 0.1607
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0158 0.1624 0.1607
Loa Loa (eye worm) hypothetical protein 0.0146 0.1481 0.2206
Trichomonas vaginalis heat shock protein, putative 0.0482 0.5399 0.8038
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0158 0.1624 0.1607
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Onchocerca volvulus 0.0158 0.1624 0.4674
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0113 0.109 0.1787
Entamoeba histolytica heat shock protein 90, putative 0.0594 0.6712 1
Loa Loa (eye worm) neuropeptide F receptor 0.0158 0.1624 0.242
Toxoplasma gondii Hsp90 domain-containing protein 0.0263 0.2845 0.4182
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Trichomonas vaginalis DNA topoisomerase II, putative 0.0113 0.109 0.1598
Mycobacterium ulcerans hypothetical protein 0.0534 0.6004 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus granulosus tm gpcr rhodopsin 0.0158 0.1624 0.2397
Plasmodium falciparum endoplasmin, putative 0.0367 0.4063 0.6014
Echinococcus granulosus sodium and chloride dependent glycine 0.0025 0.0066 0.0069
Schistosoma mansoni endoplasmin 0.0594 0.6712 1
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0113 0.109 0.1787
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0158 0.1624 0.1607
Loa Loa (eye worm) hypothetical protein 0.0113 0.109 0.1624
Brugia malayi Dopamine receptor protein 2 0.0158 0.1624 0.2397
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0113 0.109 0.1598
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0158 0.1624 0.2397
Echinococcus granulosus allatostatin A receptor 0.0158 0.1624 0.2397
Leishmania major heat shock protein 83-1 0.0594 0.6712 1
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0113 0.109 0.1787
Entamoeba histolytica heat shock protein 90, putative 0.0594 0.6712 1
Schistosoma mansoni amine GPCR 0.0158 0.1624 0.2397
Schistosoma mansoni histamine h1 receptor 0.0158 0.1624 0.2397
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0066 0.0069
Schistosoma mansoni biogenic amine receptor 0.0158 0.1624 0.2397
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0025 0.0066 0.0069
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Brugia malayi hypothetical protein 0.0158 0.1624 0.2397
Loa Loa (eye worm) TYRA-2 protein 0.0158 0.1624 0.242
Leishmania major heat shock protein 83-1 0.0594 0.6712 1
Leishmania major heat shock protein 83-1 0.0594 0.6712 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1624 0.2397
Echinococcus granulosus heat shock protein 90 0.0482 0.5399 0.8038
Trypanosoma brucei heat shock protein 90, putative 0.0594 0.6712 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0113 0.109 0.1598
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0113 0.109 0.1072
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.049 0.5494 0.9146
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0066 0.0069
Loa Loa (eye worm) norepinephrine transporter 0.0146 0.1481 0.2206
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1624 0.1607
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0113 0.109 0.154
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1624 0.2397
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0113 0.109 0.1598
Schistosoma mansoni endoplasmin 0.0594 0.6712 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1624 0.1607
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Trichomonas vaginalis heat shock protein, putative 0.0255 0.275 0.408
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0095 0.0111
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0158 0.1624 0.2397
Brugia malayi Dopamine receptor 0.0158 0.1624 0.2397
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0113 0.109 0.154
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0158 0.1624 0.2397
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0158 0.1624 0.2397
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0113 0.109 1
Onchocerca volvulus 0.0158 0.1624 0.4674
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0158 0.1624 0.1607
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0354 0.0334
Echinococcus granulosus neuropeptide s receptor 0.0158 0.1624 0.2397
Echinococcus granulosus heat shock protein 90 0.0594 0.6712 1
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0025 0.0066 0.0069
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0066 0.0069
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0066 0.0069
Loa Loa (eye worm) hypothetical protein 0.0041 0.0261 0.0389
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0158 0.1624 0.2397
Echinococcus multilocularis neuropeptides capa receptor 0.0158 0.1624 0.1607
Onchocerca volvulus 0.0158 0.1624 0.4674
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0158 0.1624 0.2397
Echinococcus multilocularis orexin receptor type 2 0.0158 0.1624 0.1607
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0025 0.0066 0.0099
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0158 0.1624 0.2397
Brugia malayi putative neuropeptide receptor NPR1 0.0158 0.1624 0.2397
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0113 0.109 0.1787
Mycobacterium tuberculosis Conserved protein 0.0113 0.109 0.1787
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0025 0.0066 0.0069
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0158 0.1624 0.2397
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0113 0.109 0.1787
Chlamydia trachomatis DNA gyrase subunit B 0.0113 0.109 1
Echinococcus multilocularis serotonin receptor 0.0158 0.1624 0.1607
Echinococcus multilocularis heat shock protein 90 0.0594 0.6712 0.6705
Trypanosoma brucei developmentally regulated phosphoprotein 0.0113 0.109 0.1598
Plasmodium vivax DNA topoisomerase II, putative 0.0113 0.109 0.154
Brugia malayi hypothetical protein 0.0158 0.1624 0.2397
Schistosoma mansoni opsin-like receptor 0.0158 0.1624 0.2397
Echinococcus granulosus serotonin receptor 0.0158 0.1624 0.2397
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0158 0.1624 0.1607
Plasmodium falciparum heat shock protein 90 0.0594 0.6712 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0113 0.109 0.1787
Brugia malayi ORL1-like opioid receptor 0.0158 0.1624 0.2397
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0113 0.109 0.1787
Echinococcus multilocularis sex peptide receptor 0.0158 0.1624 0.1607
Brugia malayi sulfakinin receptor protein 0.0158 0.1624 0.2397
Leishmania major hypothetical protein, conserved 0.0027 0.0095 0.0111
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0158 0.1624 0.242
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0158 0.1624 0.2397
Trichomonas vaginalis endoplasmin, putative 0.0367 0.4063 0.6042
Echinococcus multilocularis neuropeptides capa receptor 0.0158 0.1624 0.1607
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0354 0.0527
Brugia malayi hypothetical protein 0.0027 0.0095 0.0111
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0158 0.1624 0.2397
Toxoplasma gondii DNA topoisomerase 2, putative 0.0113 0.109 0.154
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus granulosus neuropeptide receptor 0.0158 0.1624 0.2397
Wolbachia endosymbiont of Brugia malayi trans-2-enoyl-ACP reductase, FabK 0.0534 0.6004 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0158 0.1624 0.2397
Trypanosoma brucei RNA helicase, putative 0.0563 0.6342 0.9447
Trichomonas vaginalis heat shock protein, putative 0.049 0.5494 0.818
Leishmania major heat shock protein 83-1 0.0594 0.6712 1
Plasmodium falciparum DNA gyrase subunit B 0.0113 0.109 0.154
Echinococcus granulosus heat shock protein 0.0594 0.6712 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.049 0.5494 0.896
Plasmodium vivax endoplasmin, putative 0.0594 0.6712 1
Brugia malayi RE15519p 0.0158 0.1624 0.2397
Echinococcus granulosus neuropeptides capa receptor 0.0158 0.1624 0.2397
Onchocerca volvulus 0.0158 0.1624 0.4674
Onchocerca volvulus 0.0158 0.1624 0.4674
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0099
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.053 0.051
Trypanosoma cruzi heat shock protein, putative 0.031 0.3399 0.505
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0095 0.0043
Brugia malayi Melatonin receptor type 1A 0.0158 0.1624 0.2397
Mycobacterium tuberculosis Probable two component sensor kinase 0.0113 0.109 0.1787
Echinococcus granulosus fmrfamide receptor 0.0158 0.1624 0.2397
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1624 0.2397
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0158 0.1624 0.1607
Echinococcus granulosus g-protein coupled receptor 0.0158 0.1624 0.2397
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0113 0.109 0.1787
Leishmania major heat shock protein 83-1 0.0594 0.6712 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0021 0.0031
Echinococcus multilocularis neuropeptide receptor 0.0158 0.1624 0.1607
Trypanosoma brucei heat shock protein 84, putative 0.031 0.3399 0.505
Schistosoma mansoni neuropeptide receptor 0.0158 0.1624 0.2397
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0113 0.109 0.1787
Echinococcus multilocularis rhodopsin orphan GPCR 0.0158 0.1624 0.1607
Trypanosoma cruzi heat shock protein 90, putative 0.0594 0.6712 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0158 0.1624 0.1607
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0113 0.109 0.1598
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0354 0.0498
Plasmodium vivax DNA gyrase subunit B, putative 0.0113 0.109 0.154
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0095 0.0043
Echinococcus granulosus endoplasmin 0.049 0.5494 0.818
Brugia malayi Endoplasmin precursor 0.0594 0.6712 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0158 0.1624 0.2397
Schistosoma mansoni heat shock protein 0.0594 0.6712 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0158 0.1624 0.2397
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Schistosoma mansoni neuropeptide F-like receptor 0.0158 0.1624 0.2397
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1624 0.2397
Mycobacterium ulcerans 2-nitropropane dioxygenase 0.0534 0.6004 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0354 0.0498
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0158 0.1624 0.1607
Echinococcus granulosus hypothetical protein 0.0158 0.1624 0.2397
Mycobacterium ulcerans hypothetical protein 0.0198 0.2084 0.3448
Leishmania major heat shock protein 83-1 0.0594 0.6712 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0113 0.109 0.1787
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0354 0.0498
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0158 0.1624 0.2397
Echinococcus granulosus rhodopsin orphan GPCR 0.0158 0.1624 0.2397
Trypanosoma brucei DNA topoisomerase ii 0.0113 0.109 0.1598
Loa Loa (eye worm) hypothetical protein 0.0021 0.0021 0.0031
Onchocerca volvulus 0.0146 0.1481 0.4243
Schistosoma mansoni sodium-dependent amino acid transporter 0.0025 0.0066 0.0069
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.053 0.0761
Leishmania major heat shock protein 83-1 0.0594 0.6712 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Trichomonas vaginalis sensor histidine kinase, putative 0.0113 0.109 0.1598
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0099
Treponema pallidum heat shock protein 90 0.049 0.5494 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0158 0.1624 0.2397
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0113 0.109 0.1787
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0158 0.1624 0.2397
Echinococcus granulosus tm gpcr rhodopsin 0.0158 0.1624 0.2397
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1624 0.2397
Brugia malayi neuropeptide F receptor 0.0158 0.1624 0.2397
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0025 0.0066 0.0069
Echinococcus granulosus tm gpcr rhodopsin 0.0158 0.1624 0.2397
Trypanosoma cruzi heat shock protein 85, putative 0.0594 0.6712 1
Echinococcus granulosus g protein coupled receptor 0.0158 0.1624 0.2397
Leishmania major heat shock protein 83-1 0.0594 0.6712 1
Brugia malayi Bromodomain containing protein 0.0081 0.0723 0.1049
Brugia malayi hypothetical protein 0.0158 0.1624 0.2397
Brugia malayi heat shock protein 90 0.0594 0.6712 1
Leishmania major heat shock protein 83-1 0.0594 0.6712 1
Trypanosoma cruzi heat shock protein 90, putative 0.034 0.3739 0.5557
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0158 0.1624 0.2397
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0142
Echinococcus granulosus 7TM GPCR rhodopsin 0.0158 0.1624 0.2397
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0113 0.109 0.1598
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0113 0.109 0.154
Schistosoma mansoni DNA topoisomerase II 0.0113 0.109 0.1598
Trypanosoma brucei heat shock protein, putative 0.0594 0.6712 1
Brugia malayi hypothetical protein 0.0158 0.1624 0.2397
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0066 0.0069
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0025 0.0066 0.0069
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0025 0.0066 0.0069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0354 0.0498
Leishmania major heat shock protein 83-1 0.0594 0.6712 1
Onchocerca volvulus 0.0158 0.1624 0.4674
Mycobacterium ulcerans hypothetical protein 0.0198 0.2084 0.3448
Loa Loa (eye worm) hypothetical protein 0.0046 0.0315 0.0469
Toxoplasma gondii heat shock protein 90, putative 0.0594 0.6712 1
Mycobacterium ulcerans two component regulator - sensor kinase 0.0113 0.109 0.1787
Schistosoma mansoni opsin-like receptor 0.0158 0.1624 0.2397
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0158 0.1624 0.2397
Trypanosoma brucei Heat shock protein 83, putative 0.0594 0.6712 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0095 0.0111
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0158 0.1624 0.2397
Trichomonas vaginalis 2-nitropropane dioxygenase precursor, putative 0.0534 0.6004 0.8943
Brugia malayi neuropeptide F receptor 0.0158 0.1624 0.2397
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0025 0.0066 0.0069
Echinococcus multilocularis heat shock protein 0.0594 0.6712 0.6705
Trypanosoma cruzi heat shock protein 90, putative 0.0482 0.5399 0.8038
Onchocerca volvulus Neuropeptide F receptor homolog 0.0158 0.1624 0.4674
Echinococcus multilocularis g-protein coupled receptor 0.0158 0.1624 0.1607
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0113 0.109 0.1787
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0095 0.0043
Loa Loa (eye worm) heat shock protein 75 0.031 0.3399 0.5065
Schistosoma mansoni sodium/chloride dependent transporter 0.0146 0.1481 0.2182
Schistosoma mansoni heat shock protein 0.0594 0.6712 1
Trypanosoma brucei heat shock protein, putative 0.0594 0.6712 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0158 0.1624 0.2397
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0354 0.0498
Echinococcus multilocularis sodium and chloride dependent glycine 0.0025 0.0066 0.0046
Echinococcus multilocularis neuropeptide s receptor 0.0158 0.1624 0.1607
Echinococcus granulosus tachykinin peptides receptor 99D 0.0158 0.1624 0.2397
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Onchocerca volvulus 0.0158 0.1624 0.4674
Schistosoma mansoni zinc finger protein 0.0021 0.0024 0.0005
Loa Loa (eye worm) hypothetical protein 0.0158 0.1624 0.242
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0158 0.1624 0.1607
Brugia malayi hypothetical protein 0.0158 0.1624 0.2397
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0113 0.109 0.1598
Leishmania major heat shock protein 83-1 0.0594 0.6712 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2.7 nM Binding affinity to human SERT ChEMBL. 17616397
Ki (binding) = 2.7 nM Binding affinity to human SERT ChEMBL. 17616397
Ki (binding) = 4 nM Binding affinity to human histamine H3 receptor ChEMBL. 17616397
Ki (binding) = 4 nM Binding affinity to human histamine H3 receptor ChEMBL. 17616397

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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