Detailed information for compound 45115

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 559.678 | Formula: C27H37N5O6S
  • H donors: 4 H acceptors: 6 LogP: -0.12 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(CC1)C(=O)[C@H](NC(=O)C(N)(C)C)CCCc1ccccc1
  • InChi: 1S/C27H37N5O6S/c1-27(2,28)26(36)29-22(13-8-11-20-9-4-3-5-10-20)25(35)32-17-15-31(16-18-32)23-14-7-6-12-21(23)30-39(37,38)19-24(33)34/h3-7,9-10,12,14,22,30H,8,11,13,15-19,28H2,1-2H3,(H,29,36)(H,33,34)/t22-/m1/s1
  • InChiKey: XEQZWAYIVODKJP-JOCHJYFZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens growth hormone secretagogue receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni rhodopsin-like orphan GPCR growth hormone secretagogue receptor 289 aa 243 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hexose transporter 0.0032 0.0484 0.6562
Schistosoma mansoni sugar transporter 0.0015 0.0074 0.0218
Giardia lamblia Multidrug resistance-associated protein Mrp2 0.004 0.0665 0.9462
Echinococcus granulosus ATP binding cassette sub family B 0.004 0.0665 0.2328
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.003 0.0423 0.1467
Plasmodium vivax ABC transporter B family member 6, putative 0.0042 0.0699 0.063
Echinococcus multilocularis ATP binding cassette sub family B 0.0042 0.0699 0.2448
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0459 0.1405
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0274 0.3197
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0063 0.1196 0.4217
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0198 0.0661
Leishmania major ATP-binding cassette protein subfamily B, member 1, putative 0.0042 0.0699 0.2446
Schistosoma mansoni nuclear receptor 0.003 0.0423 0.1464
Echinococcus granulosus General substrate transporter 0.009 0.1813 0.6417
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0274 0.0201
Loa Loa (eye worm) hypothetical protein 0.0025 0.0323 0.0828
Echinococcus multilocularis ATP binding cassette sub family B 0.0042 0.0699 0.2448
Brugia malayi major facilitator superfamily protein 0.0015 0.0074 0.0218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0063 0.1196 0.315
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0133 0.2818 1
Echinococcus granulosus multidrug resistance protein 1 0.0133 0.2818 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.036 0.0925
Schistosoma mansoni protein kinase 0.0032 0.0474 0.1646
Brugia malayi ABC transporter 0.004 0.0665 0.2326
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0042 0.0699 0.1047
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0133 0.2818 1
Plasmodium falciparum proline--tRNA ligase 0.0037 0.058 0.0568
Schistosoma mansoni steroid hormone receptor ad4bp 0.0063 0.1196 0.4217
Trypanosoma cruzi ABC transporter of the mitochondrion, putative 0.0042 0.0699 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0063 0.1196 0.4217
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0198 0.0661
Giardia lamblia ABC transporter, putative 0.0042 0.0699 1
Echinococcus granulosus hyperpolarization activated cyclic 0.002 0.0198 0.0664
Echinococcus granulosus ATP binding cassette sub family B 0.0042 0.0699 0.2448
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0093 0.1887 0.6606
Brugia malayi ABC transporter family protein 0.0042 0.0699 0.2446
Loa Loa (eye worm) hypothetical protein 0.004 0.0665 0.1738
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0423 0.1467
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0063 0.1196 0.4219
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.002 0.0198 0.0661
Schistosoma mansoni nuclear hormone receptor 0.0063 0.1196 0.4217
Loa Loa (eye worm) hypothetical protein 0.0033 0.0506 0.1314
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0133 0.2818 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0506 0.1761
Schistosoma mansoni multidrug resistance protein 0.0042 0.0699 0.2446
Trichomonas vaginalis ABC transporter, putative 0.0133 0.2818 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0063 0.1196 0.4217
Plasmodium vivax ABC transporter B family member 3, putative 0.0042 0.0699 0.063
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0081 0.1611 0.5696
Schistosoma mansoni multidrug resistance protein 0.0133 0.2818 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0423 0.1467
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0063 0.1196 0.4217
Loa Loa (eye worm) hypothetical protein 0.0033 0.0506 0.1314
Loa Loa (eye worm) hypothetical protein 0.0063 0.1196 0.315
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0042 0.0699 0.1047
Giardia lamblia Multidrug resistance-associated protein 1 0.0042 0.0699 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.2785 0.7381
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0475 0.0463
Loa Loa (eye worm) hypothetical protein 0.0133 0.2818 0.7471
Trichomonas vaginalis ABC transporter, putative 0.0133 0.2818 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0133 0.2818 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0063 0.1196 0.315
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0042 0.0699 0.2446
Brugia malayi nuclear hormone receptor family member nhr-6 0.003 0.0423 0.1464
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0042 0.0699 0.1047
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0274 0.0931
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0074 0.0218
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0198 0.0453
Brugia malayi ABC transporter transmembrane region family protein 0.0042 0.0699 0.2446
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0027 0.036 0.124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0063 0.1196 0.315
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0133 0.2818 1
Brugia malayi ABC transporter transmembrane region family protein 0.0042 0.0699 0.2446
Leishmania major ATP-binding cassette protein subfamily C, member 8, putative 0.0042 0.0699 0.2446
Loa Loa (eye worm) hypothetical protein 0.0174 0.3768 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0133 0.2818 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0475 0.0463
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0274 0.0728
Trypanosoma brucei glucose transporter, putative 0.0032 0.0484 0.6562
Echinococcus multilocularis hyperpolarization activated cyclic 0.002 0.0198 0.0664
Brugia malayi nuclear receptor RXR 0.0033 0.0506 0.1759
Brugia malayi ABC transporter transmembrane region family protein 0.004 0.0665 0.2326
Mycobacterium tuberculosis Iron-regulated transporter IrtA 0.0042 0.0699 0.248
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0163
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.058 0.2021
Brugia malayi ABC transporter family protein 0.0133 0.2818 1
Echinococcus multilocularis FTZ F1 alpha 0.0063 0.1196 0.4219
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0081 0.1611 0.4256
Brugia malayi ABC transporter family protein 0.0042 0.0699 0.2446
Loa Loa (eye worm) hypothetical protein 0.0063 0.1196 0.315
Onchocerca volvulus 0.003 0.0423 0.1274
Trypanosoma cruzi multidrug resistance protein E, putative 0.0042 0.0699 1
Trichomonas vaginalis ABC transporter, putative 0.0133 0.2818 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0423 0.1467
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0063 0.1196 0.4217
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0474 0.1649
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0042 0.0699 1
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0506 0.1759
Echinococcus multilocularis multidrug resistance protein 1 0.0133 0.2818 1
Entamoeba histolytica P-glycoprotein-2 0.0133 0.2818 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0163
Schistosoma mansoni glucose transport protein 0.0105 0.2153 0.7628
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0484 0.1494
Schistosoma mansoni glucose transport protein 0.0105 0.2153 0.7628
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0475 0.0705
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2153 0.7628
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0074 0.0163
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0081 0.1611 0.5698
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0429 0.1485
Echinococcus granulosus cGMP dependent protein kinase 0.0012 0.0013 0.0003
Echinococcus granulosus multidrug resistance protein 1 0.0133 0.2818 1
Trichomonas vaginalis ABC transporter, putative 0.0133 0.2818 1
Schistosoma mansoni nuclear receptor nhr-48 0.003 0.0423 0.1464
Giardia lamblia Hypothetical protein 0.004 0.0665 0.9462
Brugia malayi multidrug resistance related protein 1 0.0042 0.0699 0.2446
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0484 0.168
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0133 0.2818 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0042 0.0699 0.2277
Toxoplasma gondii ATP-binding cassette sub-family B member 5 0.0042 0.0699 0.1047
Loa Loa (eye worm) hypothetical protein 0.0033 0.0506 0.1314
Entamoeba histolytica ABC transporter, putative 0.0042 0.0699 0.1671
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0174 0.3768 1
Plasmodium falciparum protein kinase 7 0.0295 0.6568 0.6564
Loa Loa (eye worm) multidrug resistance protein 3 0.0133 0.2818 0.7471
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0133 0.2818 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0133 0.2818 1
Brugia malayi ecdysone receptor 0.003 0.0423 0.1464
Onchocerca volvulus 0.0133 0.2818 1
Schistosoma mansoni voltage-gated potassium channel 0.0088 0.1773 0.6273
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0027 0.036 0.1238
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0274 0.0931
Echinococcus multilocularis solute carrier family 22 0.0015 0.0074 0.0221
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.058 0.051
Brugia malayi Steroid receptor seven-up type 2 0.0063 0.1196 0.4217
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0074 0.0221
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.003 0.0423 0.1467
Loa Loa (eye worm) hypothetical protein 0.002 0.0198 0.0494
Brugia malayi nuclear hormone receptor family member odr-7 0.003 0.0423 0.1464
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0274 0.3197
Echinococcus multilocularis ecdysone induced protein 78C 0.0063 0.1196 0.4219
Mycobacterium ulcerans drugs-transport transmembrane ATP-binding protein ABC transporter 0.0042 0.0699 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0063 0.1196 0.4217
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0133 0.2818 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0423 0.1094
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0063 0.1196 0.4219
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0133 0.2818 1
Brugia malayi nuclear receptor NHR-88 0.003 0.0423 0.1464
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0163
Loa Loa (eye worm) hypothetical protein 0.003 0.0423 0.1094
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0133 0.2818 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0198 0.0661
Entamoeba histolytica ATP-binding cassette protein, putative 0.0042 0.0699 0.1671
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.002 0.0198 0.0661
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0063 0.1196 0.4217
Plasmodium vivax multidrug resistance-associated protein 2, putative 0.0042 0.0699 0.063
Entamoeba histolytica P-glycoprotein-2 0.0133 0.2818 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.1196 0.315
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0032 0.0051
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0133 0.2818 0.7471
Plasmodium falciparum multidrug resistance-associated protein 1 0.0042 0.0699 0.0687
Schistosoma mansoni multidrug resistance protein 0.0042 0.0699 0.2446
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.2153 0.3265
Brugia malayi nuclear receptor NHR-67 0.003 0.0423 0.1464
Echinococcus multilocularis ATP binding cassette sub family B 0.0132 0.2785 0.988
Plasmodium vivax ABC transporter B family member 5, putative 0.0042 0.0699 0.063
Echinococcus granulosus solute carrier family 22 0.0015 0.0074 0.0221
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0459 0.1593
Echinococcus granulosus sodium channel protein 0.0082 0.1641 0.5805
Schistosoma mansoni hypothetical protein 0.0105 0.2153 0.7628
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0274 0.3197
Echinococcus multilocularis nuclear receptor nhr 48 0.003 0.0423 0.1467
Brugia malayi Sugar transporter family protein 0.0015 0.0074 0.0218
Echinococcus multilocularis multidrug resistance associated protein 1 0.0042 0.0699 0.2448
Loa Loa (eye worm) hypothetical protein 0.003 0.0423 0.1094
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0063 0.1196 0.4219
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0423 0.1274
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0198 0.0494
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2153 0.7628
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0082 0.1641 0.5803
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0474 0.1649
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0042 0.0699 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0423 0.1094
Trypanosoma brucei glucose transporter, putative 0.0032 0.0484 0.6562
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0484 0.1494
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0081 0.1611 0.5698
Echinococcus multilocularis 0.0042 0.0699 0.2448
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0484 0.6562
Trichomonas vaginalis abcb9, putative 0.0133 0.2818 1
Plasmodium vivax multidrug resistance protein 2, putative 0.0042 0.0699 0.063
Toxoplasma gondii sugar transporter ST3 0.0015 0.0074 0.0094
Plasmodium falciparum ABC transporter B family member 7, putative 0.0042 0.0699 0.0687
Trichomonas vaginalis taga, putative 0.0133 0.2818 1
Echinococcus granulosus multidrug resistance protein 1 0.0093 0.1887 0.6681
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.036 0.1238
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0074 0.0218
Brugia malayi Sugar transporter family protein 0.0015 0.0074 0.0218
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0475 0.0404
Echinococcus granulosus thyroid hormone receptor alpha 0.003 0.0423 0.1467
Brugia malayi ABC transporter 0.0042 0.0699 0.2446
Entamoeba histolytica ATP-binding cassette protein, putative 0.0042 0.0699 0.1671
Trypanosoma brucei glucose transporter, putative 0.0032 0.0484 0.6562
Plasmodium falciparum mitogen-activated protein kinase 2 0.0169 0.3642 0.3634
Schistosoma mansoni protein kinase 0.0032 0.0474 0.1646
Entamoeba histolytica P-glycoprotein-2, putative 0.0133 0.2818 1
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.036 0.1238
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0133 0.2818 1
Entamoeba histolytica P-glycoprotein 6, putative 0.0042 0.0699 0.1671
Loa Loa (eye worm) ABC transporter 0.0042 0.0699 0.1827
Loa Loa (eye worm) hypothetical protein 0.0023 0.0274 0.0695
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0042 0.0699 1
Schistosoma mansoni glucose transporter 0.0015 0.0074 0.0218
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.058 0.8094
Brugia malayi Sugar transporter family protein 0.0105 0.2153 0.7628
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0133 0.2818 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0163
Echinococcus granulosus multidrug resistance protein 1 0.0133 0.2818 1
Schistosoma mansoni multidrug resistance protein 0.0042 0.0699 0.2446
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0459 0.1593
Trypanosoma brucei glucose transporter, putative 0.0032 0.0484 0.6562
Loa Loa (eye worm) hypothetical protein 0.0063 0.1196 0.315
Entamoeba histolytica P-glycoprotein-2, putative 0.004 0.0665 0.1538
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.004 0.0665 0.2155
Brugia malayi conserved hypotetical protein 0.003 0.0423 0.1464
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0474 0.1649
Brugia malayi Cyclic-nucleotide gated cation channel 0.002 0.0198 0.0661
Toxoplasma gondii hypothetical protein 0.0174 0.3768 0.5729
Echinococcus multilocularis ATP binding cassette sub family B 0.0042 0.0699 0.2448
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0063 0.1196 0.4219
Echinococcus granulosus ATP binding cassette sub family B 0.0042 0.0699 0.2448
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0459 0.1595
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0506 0.1759
Leishmania major glucose transporter, lmgt1 0.0032 0.0484 0.168
Loa Loa (eye worm) hypothetical protein 0.0033 0.0506 0.1314
Echinococcus granulosus multidrug resistance associated protein 1 0.0042 0.0699 0.2448
Loa Loa (eye worm) hypothetical protein 0.003 0.0423 0.1094
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0027 0.036 0.124
Plasmodium falciparum ABC transporter B family member 4, putative 0.0042 0.0699 0.0687
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0133 0.2818 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0063 0.1196 0.4219
Brugia malayi hypothetical protein 0.0033 0.0506 0.1759
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0133 0.2818 1
Plasmodium falciparum hexose transporter 0.0105 0.2153 0.2143
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0074 0.0221
Plasmodium vivax hexose transporter 0.0105 0.2153 0.2094
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0475 0.0404
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0074 0.0218
Trypanosoma brucei ABC transporter of the mitochondrion, putative 0.0042 0.0699 1
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0042 0.0699 0.1827
Echinococcus granulosus hyperpolarization activated cyclic 0.002 0.0198 0.0664
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0133 0.2818 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0274 0.0931
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.002 0.0198 0.0494
Schistosoma mansoni ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7) 0.0042 0.0699 0.2446
Loa Loa (eye worm) hypothetical protein 0.0063 0.1196 0.315
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0475 0.0463
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0063 0.1196 0.4219
Loa Loa (eye worm) hypothetical protein 0.0033 0.0506 0.1314
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.058 0.2021
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.002 0.0198 0.0664
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0063 0.1196 0.4219
Echinococcus multilocularis solute carrier family 22 0.0015 0.0074 0.0221
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0133 0.2818 0.428
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0063 0.1196 0.4217
Schistosoma mansoni sugar transporter 0.0015 0.0074 0.0218
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0133 0.2818 1
Schistosoma mansoni smdr2 0.0133 0.2818 1
Toxoplasma gondii ABC transporter, putative 0.0042 0.0699 0.1047
Schistosoma mansoni retinoic acid receptor RXR 0.0063 0.1196 0.4217
Entamoeba histolytica P-glycoprotein 5, putative 0.0133 0.2818 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0484 0.6562
Echinococcus multilocularis multidrug resistance associated protein 7 0.0042 0.0699 0.2448
Brugia malayi Nuclear hormone receptor E75 0.003 0.0423 0.1464
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0063 0.1196 0.4217
Echinococcus granulosus solute carrier family 22 0.0015 0.0074 0.0221
Echinococcus granulosus ecdysone induced protein 78C 0.0063 0.1196 0.4219
Loa Loa (eye worm) hypothetical protein 0.003 0.0423 0.1094
Toxoplasma gondii ABC transporter family protein 0.0042 0.0699 0.1047
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0063 0.1196 0.4217
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0163
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0274 0.3197
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0074 0.0262
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.058 0.8094
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0198 0.0664
Leishmania major glucose transporter, lmgt2 0.0032 0.0484 0.168
Toxoplasma gondii protein kinase, putative 0.0295 0.6568 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0423 0.1094
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0133 0.2818 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0192 0.0682
Echinococcus granulosus solute carrier family 22 0.0015 0.0074 0.0221
Loa Loa (eye worm) nuclear receptor nhr-7B 0.003 0.0423 0.1094
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0042 0.0699 0.2446
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0063 0.1196 0.315
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0475 0.0463
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0163
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0423 0.1467
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0506 0.1314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0063 0.1196 0.315
Echinococcus multilocularis thyroid hormone receptor alpha 0.0063 0.1196 0.4219
Loa Loa (eye worm) hypothetical protein 0.003 0.0423 0.1094
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0063 0.1196 0.4219
Echinococcus multilocularis multidrug resistance protein 1 0.0093 0.1887 0.6681
Schistosoma mansoni thyroid hormone receptor 0.0063 0.1196 0.4217
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0082 0.1641 0.5805
Echinococcus multilocularis hyperpolarization activated cyclic 0.002 0.0198 0.0664
Loa Loa (eye worm) sugar transporter 0.0105 0.2153 0.5698
Loa Loa (eye worm) hypothetical protein 0.0031 0.0459 0.119
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0475 0.0705
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0163
Loa Loa (eye worm) hypothetical protein 0.004 0.0665 0.1738
Echinococcus granulosus multidrug resistance protein 1 0.0093 0.1887 0.6681
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0429 0.1485
Loa Loa (eye worm) hypothetical protein 0.0063 0.1196 0.315
Brugia malayi hypothetical protein 0.003 0.0423 0.1464
Onchocerca volvulus Protein ultraspiracle homolog 0.0063 0.1196 0.4088
Schistosoma mansoni coup transcription factor 0.0063 0.1196 0.4217
Entamoeba histolytica P-glycoprotein 6, putative 0.0042 0.0699 0.1671
Schistosoma mansoni smdr1 0.0042 0.0699 0.2446
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.002 0.0198 0.0664
Schistosoma mansoni glucose transport protein 0.0105 0.2153 0.7628
Brugia malayi major facilitator superfamily protein 0.0015 0.0074 0.0218
Brugia malayi hypothetical protein 0.0015 0.0074 0.0218
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0074 0.0221
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0459 0.617
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0506 0.1759
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0133 0.2818 1
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0013 0.0003
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0013 0.0003
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0474 0.1649
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.002 0.0198 0.0664
Brugia malayi hypothetical protein 0.003 0.0423 0.1464
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0274 0.0398
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0144 0.1119
Schistosoma mansoni nuclear hormone receptor 0.003 0.0423 0.1464
Entamoeba histolytica protein kinase, putative 0.0032 0.0474 0.0789
Brugia malayi P-glycoprotein-like protein 0.0042 0.0699 0.2446
Mycobacterium tuberculosis Probable drugs-transport transmembrane ATP-binding protein ABC transporter 0.0042 0.0699 0.248
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0274 0.0931
Schistosoma mansoni sugar transporter 0.0015 0.0074 0.0218
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0042 0.0699 1
Echinococcus granulosus multidrug resistance associated protein 7 0.0042 0.0699 0.2448
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0074 0.0163
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.1379 0.4756
Wolbachia endosymbiont of Brugia malayi ABC-type protease secretion system, ATPase and permease component, AprD 0.0042 0.0699 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0274 0.3197
Leishmania major ABC-thiol transporter 0.0042 0.0699 0.2446
Echinococcus multilocularis solute carrier family 22 0.0015 0.0074 0.0221
Loa Loa (eye worm) DR-78 0.003 0.0423 0.1094
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0474 0.146
Echinococcus multilocularis multidrug resistance protein 1 0.0133 0.2818 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0042 0.0699 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0699 0.1827
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.003 0.0423 0.1464
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0063 0.1196 0.4219
Schistosoma mansoni RAR-like nuclear receptor 0.0063 0.1196 0.4217
Brugia malayi multidrug resistance protein 3 0.0133 0.2818 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0063 0.1196 0.4217
Echinococcus multilocularis sodium channel protein 0.0082 0.1641 0.5805
Schistosoma mansoni multidrug resistance protein 0.004 0.0665 0.2326
Trichomonas vaginalis abcb9, putative 0.0133 0.2818 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.002 0.0198 0.0664
Brugia malayi Nuclear hormone receptor E75 0.003 0.0423 0.1464
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0459 0.5275
Entamoeba histolytica multidrug resistance protein, putative 0.0042 0.0699 0.1671
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.004 0.0665 0.2155
Plasmodium falciparum ABC transporter B family member 6, putative 0.0042 0.0699 0.0687
Leishmania major p-glycoprotein e 0.0042 0.0699 0.2446
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0063 0.1196 0.315
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0274 0.0933
Plasmodium vivax ABC transporter B family member 4, putative 0.0042 0.0699 0.063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0459 0.119
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0063 0.1196 0.4217
Plasmodium falciparum multidrug resistance protein 2 0.0042 0.0699 0.0687
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0074 0.0061
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.2153 0.7628
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0042 0.0699 0.1047
Loa Loa (eye worm) hypothetical protein 0.0133 0.2818 0.7471
Entamoeba histolytica P-glycoprotein-5 0.0133 0.2818 1
Plasmodium falciparum ABC transporter B family member 5, putative 0.0042 0.0699 0.0687
Schistosoma mansoni sugar transporter 0.0015 0.0074 0.0218
Schistosoma mansoni voltage-gated potassium channel 0.0088 0.1773 0.6273
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0063 0.1196 0.4219
Trypanosoma brucei glucose transporter 1E 0.0032 0.0484 0.6562
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0506 0.1759
Trypanosoma brucei glucose transporter, putative 0.0032 0.0484 0.6562
Trypanosoma brucei p-glycoprotein 0.0042 0.0699 1
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0484 0.1494
Entamoeba histolytica hypothetical protein 0.0042 0.0699 0.1671
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0274 0.0933
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0063 0.1196 0.4217
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0484 0.1494
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0459 0.1593
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0484 0.6562
Brugia malayi hypothetical protein 0.0015 0.0074 0.0218
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0459 0.073
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2153 0.7628
Echinococcus multilocularis General substrate transporter 0.009 0.1813 0.6417
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0127 0.0409
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2153 0.7628
Leishmania major p-glycoprotein 0.0133 0.2818 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0192 0.0682
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0474 0.1646
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0133 0.2818 1
Plasmodium falciparum multidrug resistance protein 1 0.0133 0.2818 0.2809
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.004 0.0665 0.2155
Entamoeba histolytica P-glycoprotein-1 0.0133 0.2818 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0169 0.3642 0.5537
Entamoeba histolytica P-glycoprotein 5, putative 0.004 0.0665 0.1538
Loa Loa (eye worm) hypothetical protein 0.003 0.0423 0.1094
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0042 0.0699 1
Schistosoma mansoni zinc finger protein 0.003 0.0423 0.1464
Loa Loa (eye worm) hypothetical protein 0.003 0.0423 0.1094
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0506 0.1761
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0475 0.0404
Leishmania major ATP-binding cassette protein subfamily B, member 3, putative 0.0042 0.0699 0.2446
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0163
Brugia malayi Cam kinase protein 1 0.0032 0.0474 0.1646
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0133 0.2818 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0274 0.1607
Mycobacterium leprae PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER 0.0042 0.0699 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0063 0.1196 0.4217
Brugia malayi tailless protein 0.003 0.0423 0.1464
Brugia malayi nuclear receptor RXR 0.003 0.0423 0.1464
Echinococcus granulosus solute carrier family 22 0.0015 0.0074 0.0221
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0474 0.123
Trichomonas vaginalis abcb9, putative 0.0133 0.2818 1
Echinococcus multilocularis ATP binding cassette sub family B 0.0042 0.0699 0.2448
Trypanosoma brucei ABC transporter, mitochondrial, putative 0.0042 0.0699 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0133 0.2818 1
Schistosoma mansoni thyroid hormone receptor 0.0063 0.1196 0.4217
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0484 0.1494
Echinococcus multilocularis solute carrier family 22 0.0015 0.0074 0.0221
Entamoeba histolytica protein kinase, putative 0.0032 0.0474 0.0789
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0133 0.2818 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2153 0.7628
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0074 0.0221
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0475 0.0463
Leishmania major pentamidine resistance protein 1 0.0042 0.0699 0.2446
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0474 0.1646
Schistosoma mansoni multidrug resistance protein 0.0133 0.2818 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0133 0.2818 1
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0074 0.0218
Brugia malayi hypothetical protein 0.0033 0.0506 0.1759
Schistosoma mansoni multidrug resistance protein 0.0042 0.0699 0.2446
Echinococcus granulosus FTZ F1 alpha 0.0063 0.1196 0.4219
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0163
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0459 0.1593
Echinococcus multilocularis expressed conserved protein 0.0012 0.0013 0.0003
Mycobacterium ulcerans component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD 0.0042 0.0699 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.1379 0.4756
Schistosoma mansoni nuclear receptor 0.003 0.0423 0.1464
Brugia malayi orphan nuclear receptor NR2E1 0.003 0.0423 0.1464
Onchocerca volvulus 0.003 0.0423 0.1274
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0012 0.0013 0.0003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0699 0.1827
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0474 0.641
Brugia malayi Nuclear hormone receptor-like 1 0.0063 0.1196 0.4217
Brugia malayi nuclear hormone receptor 0.0063 0.1196 0.4217
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0042 0.0699 0.1047
Brugia malayi ecdysteroid receptor 0.0063 0.1196 0.4217
Loa Loa (eye worm) sugar transporter 0.0015 0.0074 0.0163
Plasmodium falciparum multidrug resistance-associated protein 2 0.0042 0.0699 0.0687
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.2153 0.7628
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.2153 0.7575
Loa Loa (eye worm) ABC transporter 0.0042 0.0699 0.1827
Plasmodium vivax ABC transporter B family member 7, putative 0.0042 0.0699 0.063
Schistosoma mansoni nuclear hormone receptor 0.003 0.0423 0.1464
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0063 0.1196 0.4217
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0133 0.2818 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0474 0.1649
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0423 0.1467
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0063 0.1196 0.4217
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.058 0.8094
Giardia lamblia Multidrug resistance-associated protein 1 0.0042 0.0699 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0484 0.6562
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0063 0.1196 0.315
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0063 0.1196 0.4217
Schistosoma mansoni multidrug resistance protein 0.0042 0.0699 0.2446
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0063 0.1196 0.4217
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0133 0.2818 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.003 0.0423 0.1464
Loa Loa (eye worm) hypothetical protein 0.0063 0.1196 0.315
Wolbachia endosymbiont of Brugia malayi ABC-type multidrug transport system, ATPase and permease component 0.0042 0.0699 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0484 0.6562
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0423 0.1467
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0042 0.0699 0.1047
Trypanosoma cruzi ABC transporter, mitochondrial, putative 0.0042 0.0699 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0484 0.6562
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0042 0.0699 1
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0133 0.2818 0.428
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0163
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0475 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0063 0.1196 0.4217
Plasmodium vivax CDK-related protein kinase 6, putative 0.0444 1 1
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0274 0.0261
Trypanosoma brucei multidrug resistance protein E 0.0042 0.0699 1
Loa Loa (eye worm) ABC transporter 0.0042 0.0699 0.1827
Loa Loa (eye worm) nuclear hormone receptor 0.003 0.0423 0.1094
Entamoeba histolytica P-glyco protein 6, putative 0.0133 0.2818 1
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0074 0.0218
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.002 0.0198 0.0664
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0042 0.0699 0.063
Brugia malayi steroid hormone receptor 0.0063 0.1196 0.4217
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0133 0.2818 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.058 0.0865
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0042 0.0699 0.2446
Leishmania major glucose transporter, lmgt3 0.0032 0.0484 0.168
Plasmodium vivax multidrug resistance protein 1, putative 0.0133 0.2818 0.2765
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.003 0.0423 0.1464
Onchocerca volvulus 0.0063 0.1196 0.4088
Brugia malayi nuclear hormone receptor 0.003 0.0423 0.1464
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0665 0.2155
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0063 0.1196 0.4219
Loa Loa (eye worm) hypothetical protein 0.003 0.0423 0.1094
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0042 0.0699 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0474 0.123
Giardia lamblia MRP-like ABC transporter 0.0042 0.0699 1
Plasmodium falciparum ABC transporter B family member 3, putative 0.0042 0.0699 0.0687
Echinococcus granulosus voltage gated potassium channel 0.0027 0.036 0.124
Brugia malayi hypothetical protein 0.0042 0.0699 0.2446
Loa Loa (eye worm) hypothetical protein 0.003 0.0423 0.1094
Schistosoma mansoni multidrug resistance protein 0.0133 0.2818 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0474 0.1649
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0074 0.0262
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0484 0.6562
Loa Loa (eye worm) hypothetical protein 0.0174 0.3768 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0133 0.2818 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0042 0.0699 0.1671
Toxoplasma gondii sugar transporter ST2 0.0015 0.0074 0.0094
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0063 0.1196 0.4219
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0074 0.0094
Brugia malayi multidrug Resistance Protein family member (mrp-5), putative 0.0042 0.0699 0.2446
Trypanosoma brucei glucose transporter, putative 0.0032 0.0484 0.6562
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0133 0.2818 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0207 0.0486
Loa Loa (eye worm) steroid hormone receptor 0.0063 0.1196 0.315
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0474 0.1649
Leishmania major hypothetical protein, conserved 0.0015 0.0074 0.0218
Brugia malayi ABC transporter family protein 0.0042 0.0699 0.2446
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0133 0.2818 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0475 0.0705
Loa Loa (eye worm) hypothetical protein 0.0063 0.1196 0.315
Loa Loa (eye worm) hypothetical protein 0.003 0.0423 0.1094
Onchocerca volvulus Bile acid receptor homolog 0.0063 0.1196 0.4088
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0133 0.2818 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0163
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0133 0.2818 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0423 0.1274
Loa Loa (eye worm) hypothetical protein 0.0071 0.1378 0.3636
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0198 0.0661
Echinococcus granulosus cGMP dependent protein kinase 1 0.0012 0.0013 0.0003
Brugia malayi nuclear receptor NHR-88 0.0063 0.1196 0.4217
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0169 0.3642 0.3595
Loa Loa (eye worm) hypothetical protein 0.0174 0.3768 1
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0042 0.0699 0.2446
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.2153 0.7628
Brugia malayi photoreceptor-specific nuclear receptor 0.0063 0.1196 0.4217
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0484 0.1494
Trypanosoma brucei glucose transporter 2A 0.0032 0.0484 0.6562
Echinococcus granulosus cyclic nucleotide gated cation channel 0.002 0.0198 0.0664
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0163
Entamoeba histolytica ATP-binding cassette protein, putative 0.0042 0.0699 0.1671
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0484 0.1494
Schistosoma mansoni ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6) 0.004 0.0665 0.2326
Toxoplasma gondii sugar transporter ST1 0.0015 0.0074 0.0094
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0459 0.1595
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0063 0.1196 0.4219
Giardia lamblia Multidrug resistance-associated protein 1 0.004 0.0665 0.9462
Loa Loa (eye worm) hypothetical protein 0.0042 0.0699 0.1827
Schistosoma mansoni protein kinase 0.0032 0.0474 0.1646
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0474 0.1649
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.003 0.0423 0.1467
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0133 0.2818 1
Leishmania major protein kinase, putative 0.0032 0.0474 0.1646
Brugia malayi hypothetical protein 0.0015 0.0074 0.0218
Schistosoma mansoni 60S ribosomal protein L21 0.0017 0.0127 0.0409
Loa Loa (eye worm) hypothetical protein 0.0032 0.0474 0.123
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0132 0.2785 0.988
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0484 0.6562
Loa Loa (eye worm) nuclear receptor NHR-67 0.003 0.0423 0.1094
Echinococcus granulosus nuclear receptor nhr 48 0.003 0.0423 0.1467
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0063 0.1196 0.4088
Echinococcus multilocularis voltage gated potassium channel 0.0027 0.036 0.124
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0198 0.0453
Loa Loa (eye worm) hypothetical protein 0.0015 0.0074 0.0163

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = -8.64 Agonist activity at human GHS-R1 ChEMBL. 17329109
EC50 (functional) = 2.3 nM Concentration required for GH-releasing activity in the rat pituitary cell assay was determined in vitro ChEMBL. 9871779
EC50 (functional) = 2.3 nM Agonist activity at human GHS-R1 ChEMBL. 17329109

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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