Detailed information for compound 460921

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 350.457 | Formula: C21H26N4O
  • H donors: 1 H acceptors: 3 LogP: 2.07 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C[C@@H]1CCCC1C(=O)[C@@H]1CN(C[C@@H]1N)Cc1cc(C)c(c(c1)C)C#N
  • InChi: 1S/C21H26N4O/c1-13-6-15(7-14(2)18(13)9-23)10-25-11-19(20(24)12-25)21(26)17-5-3-4-16(17)8-22/h6-7,16-17,19-20H,3-5,10-12,24H2,1-2H3/t16-,17?,19+,20-/m0/s1
  • InChiKey: XFLMPAVFJGLLHK-NGWLPYQTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0422 0.177
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0197 0.0798
Loa Loa (eye worm) hypothetical protein 0.0015 0.0197 0.0339
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0602 0.2613
Loa Loa (eye worm) inositol-1 0.0044 0.0856 0.1771
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.2202 0.3804
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0592 0.098
Brugia malayi CXXC zinc finger family protein 0.003 0.0557 0.1122
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0394 0.1683
Plasmodium falciparum thioredoxin reductase 0.0016 0.0235 0.0195
Schistosoma mansoni cpg binding protein 0.003 0.0557 0.0938
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0602 0.3185
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0197 0.1115
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0394 0.0767
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0314 0.0313
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0593 0.084
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0076 0.0074
Schistosoma mansoni hypothetical protein 0.0031 0.0572 0.0963
Onchocerca volvulus 0.0043 0.0843 0.1453
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0572 0.0943
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0197 0.0798
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0752 0.2167
Plasmodium vivax multidomain scavenger receptor, putative 0.0043 0.0843 0.0659
Schistosoma mansoni cpg binding protein 0.0032 0.0597 0.1008
Trypanosoma brucei glucose transporter, putative 0.0032 0.0602 0.4098
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.225 0.3888
Leishmania major oligopeptidase b 0.0017 0.024 0.1393
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0856 0.5183
Plasmodium falciparum hexose transporter 0.0105 0.225 0.2218
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0013 0.0156 0.0214
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0044 0.0856 1
Schistosoma mansoni hypothetical protein 0.0043 0.0843 0.1438
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0235 0.0039
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0942 0.1593
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0197 0.134
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Echinococcus granulosus RUN 0.0043 0.0843 0.1419
Schistosoma mansoni inositol monophosphatase 0.0044 0.0856 0.1461
Toxoplasma gondii sugar transporter ST1 0.0015 0.0197 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0197 0.0798
Loa Loa (eye worm) hypothetical protein 0.0017 0.024 0.0432
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0879 0.1821
Schistosoma mansoni loxhd1 0.0043 0.0843 0.1438
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.225 1
Leishmania major hypothetical protein, conserved 0.0015 0.0197 0.1092
Toxoplasma gondii prolyl endopeptidase 0.0017 0.024 0.0303
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0197 0.0798
Echinococcus multilocularis solute carrier family 22 0.0015 0.0197 0.0286
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0076 0.0074
Brugia malayi major facilitator superfamily protein 0.0015 0.0197 0.0339
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0235 0.1362
Echinococcus granulosus voltage gated potassium channel 0.0013 0.0156 0.0214
Loa Loa (eye worm) hypothetical protein 0.0015 0.0197 0.0339
Brugia malayi Sugar transporter family protein 0.0015 0.0197 0.0339
Trypanosoma brucei glucose transporter 2A 0.0032 0.0602 0.4098
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0812 0.3555
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0602 0.3185
Loa Loa (eye worm) hypothetical protein 0.0039 0.0744 0.1529
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0394 0.0652
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0879 0.1482
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0008 0.0041 0.0012
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.0062 0.0046
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0592 0.4034
Brugia malayi hypothetical protein 0.0054 0.1089 0.2279
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0235 0.0304
Schistosoma mansoni lipoxygenase 0.018 0.3967 0.6906
Echinococcus multilocularis solute carrier family 22 0.0015 0.0197 0.0286
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0578 0.143
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.2326 0.8835
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0235 0.1362
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0422 0.177
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0602 0.4098
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Schistosoma mansoni protein kinase 0.0032 0.0592 0.1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0572 0.0943
Loa Loa (eye worm) prolyl oligopeptidase 0.0209 0.4642 1
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0148 0.324 0.5625
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0017 0.024 0.1633
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.225 0.3888
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.2107 0.4491
Giardia lamblia Alanyl dipeptidyl peptidase 0.0017 0.024 0.1131
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0197 0.0339
Trypanosoma brucei prolyl oligopeptidase, putative 0.0017 0.024 0.1633
Brugia malayi hypothetical protein 0.0015 0.0197 0.0339
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.024 0.0382
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0602 0.2613
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0041 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.024 0.0339
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.2107 0.4491
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0169 0.3721 0.5602
Leishmania major glucose transporter, lmgt1 0.0032 0.0602 0.3929
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0856 0.5828
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0394 0.2474
Schistosoma mansoni sugar transporter 0.0015 0.0197 0.0307
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0723 0.1209
Loa Loa (eye worm) hypothetical protein 0.0015 0.0197 0.0339
Plasmodium falciparum mitogen-activated protein kinase 2 0.0169 0.3721 0.3695
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0843 0.1419
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0235 0.0586
Loa Loa (eye worm) hypothetical protein 0.0031 0.0578 0.1166
Echinococcus multilocularis solute carrier family 22 0.0015 0.0197 0.0286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.2202 0.3818
Echinococcus granulosus cGMP dependent protein kinase 1 0.0008 0.0041 0.0012
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0235 0.0195
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.0062 0.0046
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0942 0.3098
Schistosoma mansoni inositol transporter 0.0148 0.324 0.5635
Entamoeba histolytica hypothetical protein 0.0023 0.0394 0.2504
Schistosoma mansoni inositol transporter 0.0148 0.324 0.5635
Treponema pallidum NADH oxidase 0.0016 0.0235 1
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0017 0.024 0.0382
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0235 0.0354
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0044 0.0856 0.124
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0044 0.0856 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0394 0.0767
Schistosoma mansoni sugar transporter 0.0015 0.0197 0.0307
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0592 0.098
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0578 0.0954
Toxoplasma gondii thioredoxin reductase 0.0047 0.0942 0.1371
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0034 0.0022
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0856 0.3752
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0062 0.0195
Plasmodium falciparum thioredoxin reductase 0.0047 0.0942 0.0904
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.1468 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0062 0.005
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0592 0.098
Echinococcus granulosus prolyl endopeptidase 0.0017 0.024 0.0361
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0592 0.1198
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0394 0.3775
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0235 0.0195
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0009 0.0062 0.005
Leishmania major trypanothione reductase 0.0047 0.0942 0.631
Loa Loa (eye worm) sugar transporter 0.0015 0.0197 0.0339
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0235 0.0423
Schistosoma mansoni sugar transporter 0.0015 0.0197 0.0307
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0148 0.324 0.5625
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0592 0.098
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0394 0.0632
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0209 0.4642 0.8089
Loa Loa (eye worm) hypothetical protein 0.0015 0.0197 0.0339
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0593 0.0554
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0197 0.0307
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Plasmodium vivax CDK-related protein kinase 6, putative 0.0444 1 1
Entamoeba histolytica protein kinase, putative 0.0032 0.0592 0.5723
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0197 0.0286
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0843 0.1419
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.024 0.0432
Echinococcus granulosus solute carrier family 22 0.0015 0.0197 0.0286
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0572 0.1153
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0578 0.1166
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0235 0.1636
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0578 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Brugia malayi Doublecortin family protein 0.0043 0.0843 0.1742
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0593 0.0554
Trypanosoma cruzi hexose transporter 0.0032 0.0602 0.3185
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0235 0.0304
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0723 0.1483
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0017 0.024 0.0339
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0592 0.098
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0017 0.024 0.0991
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0169 0.3721 0.3595
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0136 0.0207
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0592 0.1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0062 0.0195
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.1468 0.2173
Echinococcus granulosus acylamino acid releasing enzyme 0.0017 0.024 0.0361
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0422 0.0382
Brugia malayi glutathione reductase 0.0047 0.0942 0.1958
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0394 1
Schistosoma mansoni cpg binding protein 0.0032 0.0597 0.1008
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0602 0.3929
Plasmodium falciparum glutathione reductase 0.0047 0.0942 0.0904
Toxoplasma gondii sugar transporter ST2 0.0015 0.0197 0.0237
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Loa Loa (eye worm) hypothetical protein 0.0015 0.0197 0.0339
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0592 0.098
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0696 0.4591
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0422 0.2872
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0593 0.0404
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0235 0.0304
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0017 0.024 0.1393
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0593 0.0554
Schistosoma mansoni rab6-interacting 0.0043 0.0843 0.1438
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Loa Loa (eye worm) hypothetical protein 0.0015 0.0197 0.0339
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0696 0.3928
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.225 0.3888
Brugia malayi hypothetical protein 0.0043 0.0843 0.1742
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0593 0.0554
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0235 0.0354
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0592 0.1198
Echinococcus multilocularis General substrate transporter 0.009 0.1914 0.3298
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0696 0.4591
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0593 0.084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0197 0.0339
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0062 0.0072
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0394 0.0652
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0197 0.0156
Plasmodium falciparum glutathione reductase 0.0016 0.0235 0.0195
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0062 0.005
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0235 0.0972
Trypanosoma brucei glucose transporter 1E 0.0032 0.0602 0.4098
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0235 0.1362
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0328 0.1388
Toxoplasma gondii sugar transporter ST3 0.0015 0.0197 0.0237
Echinococcus granulosus cpg binding protein 0.0032 0.0597 0.0988
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0843 0.0805
Brugia malayi prolyl oligopeptidase family protein 0.0209 0.4642 1
Brugia malayi GH02984p 0.0038 0.0723 0.1483
Trypanosoma brucei glucose transporter, putative 0.0032 0.0602 0.4098
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0257 0.5734 1
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0394 0.0538
Plasmodium vivax glutathione reductase, putative 0.0047 0.0942 0.076
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.024 0.0432
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0017 0.024 0.1633
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.118 0.1734
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0197 0.0339
Loa Loa (eye worm) doublecortin family protein 0.0043 0.0843 0.1742
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0062 0.0072
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Onchocerca volvulus Prolyl endopeptidase homolog 0.0017 0.024 0.0097
Brugia malayi prolyl oligopeptidase family protein 0.007 0.1468 0.3102
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0197 0.0798
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0235 0.0586
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.0062 0.005
Brugia malayi Cam kinase protein 1 0.0032 0.0592 0.1198
Loa Loa (eye worm) hypothetical protein 0.0009 0.0062 0.0046
Schistosoma mansoni glucose transport protein 0.0105 0.225 0.3901
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0257 0.5734 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0235 0.0161
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.1468 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0696 0.3928
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0156 0.0235
Echinococcus multilocularis Polycystic kidney disease protein 0.0043 0.0843 0.1419
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0041 0.0034
Schistosoma mansoni hypothetical protein 0.0031 0.0572 0.0963
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.1468 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0422 0.058
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Loa Loa (eye worm) hypothetical protein 0.0025 0.0422 0.0828
Loa Loa (eye worm) hypothetical protein 0.0015 0.0197 0.0339
Loa Loa (eye worm) hypothetical protein 0.0017 0.024 0.0432
Echinococcus multilocularis expressed conserved protein 0.0008 0.0041 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0235 0.0304
Brugia malayi Sugar transporter family protein 0.0105 0.225 0.4801
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.2202 0.3818
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0013 0.0156 0.025
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0197 0.0237
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0044 0.0856 1
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0547 0.09
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.2326 0.8856
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0235 0.0304
Echinococcus granulosus high affinity choline transporter 1 0.0038 0.0723 0.1209
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0696 0.051
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0235 0.1603
Loa Loa (eye worm) hypothetical protein 0.0031 0.0578 0.1166
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0578 0.1166
Trypanosoma cruzi oligopeptidase b 0.0017 0.024 0.0339
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0593 0.0554
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.225 0.3888
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.1468 1
Echinococcus granulosus inositol monophosphatase 1 0.0044 0.0856 0.1442
Echinococcus multilocularis RUN 0.0043 0.0843 0.1419
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.024 0.0339
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0197 0.0286
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0017 0.024 0.0303
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0112 0.0138
Loa Loa (eye worm) hypothetical protein 0.0043 0.0843 0.1742
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.2326 0.8856
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0422 0.023
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0013 0.0156 0.0214
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0602 0.4098
Brugia malayi hypothetical protein 0.0015 0.0197 0.0339
Entamoeba histolytica protein kinase, putative 0.0032 0.0592 0.5723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.2202 0.3804
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.225 0.3888
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0572 0.0943
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0074 0.0071
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Schistosoma mansoni protein kinase 0.0032 0.0592 0.1
Brugia malayi hypothetical protein 0.0025 0.0422 0.0828
Loa Loa (eye worm) hypothetical protein 0.0031 0.0572 0.1153
Loa Loa (eye worm) hypothetical protein 0.0038 0.0723 0.1483
Mycobacterium tuberculosis Probable peptidase 0.0017 0.024 0.0179
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0696 0.0658
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1397 0.2946
Trypanosoma brucei glucose transporter, putative 0.0032 0.0602 0.4098
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0197 0.0339
Plasmodium vivax hexose transporter 0.0105 0.225 0.2094
Echinococcus granulosus sodium:myo inositol cotransporter 0.0148 0.324 0.5625
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0235 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0197 0.0798
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0197 0.1092
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0879 0.1821
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0394 0.3775
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0062 0.005
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0602 0.2613
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0235 0.0972
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0062 0.0072
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0578 0.5483
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0593 0.0404
Giardia lamblia Alanyl dipeptidyl peptidase 0.0017 0.024 0.1131
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0197 0.0339
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0266 0.0543
Schistosoma mansoni hypothetical protein 0.0031 0.0572 0.0963
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0696 0.0998
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.2107 0.4491
Echinococcus multilocularis GPCR, family 2 0.0031 0.0572 0.0943
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0752 0.2307
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.024 0.0382
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0942 0.1958
Onchocerca volvulus 0.003 0.0557 0.0811
Leishmania major glucose transporter, lmgt2 0.0032 0.0602 0.3929
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0009 0.0062 0.005
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0155 0.0248
Trypanosoma brucei glucose transporter, putative 0.0032 0.0602 0.4098
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0592 0.098
Loa Loa (eye worm) hypothetical protein 0.0015 0.0197 0.0339
Echinococcus multilocularis voltage gated potassium channel 0.0013 0.0156 0.0214
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0197 0.1115
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0314 0.0486
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0723 0.1209
Echinococcus granulosus sodium:glucose cotransporter 0.0148 0.324 0.5625
Loa Loa (eye worm) hypothetical protein 0.0015 0.0197 0.0339
Loa Loa (eye worm) hypothetical protein 0.0067 0.1397 0.2946
Loa Loa (eye worm) hypothetical protein 0.0098 0.2107 0.4491
Brugia malayi Inositol-1 0.0044 0.0856 0.1771
Trypanosoma brucei sugar transporter, putative 0.0015 0.0197 0.134
Brugia malayi hypothetical protein 0.0043 0.0843 0.1742
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Echinococcus granulosus cGMP dependent protein kinase 1 0.0008 0.0041 0.0012
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.024 0.0382
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.225 0.3888
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0592 0.2571
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0578 0.0974
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0017 0.024 0.0339
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0578 0.0974
Loa Loa (eye worm) sugar transporter 0.0105 0.225 0.4801
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0209 0.4642 0.8085
Plasmodium falciparum protein kinase 7 0.0295 0.661 0.6596
Brugia malayi hypothetical protein 0.0015 0.0197 0.0339
Schistosoma mansoni hypothetical protein 0.0105 0.225 0.3901
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.2202 0.4697
Toxoplasma gondii hypothetical protein 0.0017 0.024 0.0303
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0602 0.4098
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Schistosoma mansoni sugar transporter 0.0015 0.0197 0.0307
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.1468 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0578 0.2505
Echinococcus multilocularis high affinity choline transporter 1 0.0038 0.0723 0.1209
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0112 0.0138
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.1468 0.2533
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0062 0.005
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0593 0.0404
Schistosoma mansoni protein kinase 0.0032 0.0592 0.1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0592 0.098
Echinococcus granulosus General substrate transporter 0.009 0.1914 0.3298
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Echinococcus granulosus Polycystic kidney disease protein 0.0043 0.0843 0.1419
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0076 0.0077
Loa Loa (eye worm) hypothetical protein 0.0015 0.0197 0.0339
Schistosoma mansoni high-affinity choline transporter 0.0038 0.0723 0.1229
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.024 0.0991
Trichomonas vaginalis inositol monophosphatase, putative 0.0044 0.0856 0.3752
Loa Loa (eye worm) hypothetical protein 0.0038 0.0723 0.1483
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.225 0.3888
Loa Loa (eye worm) prolyl oligopeptidase 0.0017 0.024 0.0432
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0394 0.0201
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.024 0.0432
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0602 0.2613
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0557 0.1122
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0197 0.0286
Echinococcus granulosus GPCR family 2 0.0031 0.0572 0.0943
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0578 0.0954
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0136 0.0207
Schistosoma mansoni glucose transport protein 0.0105 0.225 0.3901
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0209 0.4642 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0235 0.1636
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0235 0.1636
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Trypanosoma brucei trypanothione reductase 0.0047 0.0942 0.6413
Brugia malayi Thioredoxin reductase 0.0047 0.0942 0.1958
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0235 0.1603
Echinococcus multilocularis prolyl endopeptidase 0.0017 0.024 0.0361
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0197 0.0798
Echinococcus granulosus solute carrier family 22 0.0015 0.0197 0.0286
Echinococcus multilocularis inositol monophosphatase 1 0.0044 0.0856 0.1442
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.2326 0.8856
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.2202 0.3818
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0235 0.4335
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0843 0.1419
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Trypanosoma brucei glucose transporter, putative 0.0032 0.0602 0.4098
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.2326 0.8856
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0972 0.1665
Loa Loa (eye worm) hypothetical protein 0.0017 0.024 0.0432
Echinococcus granulosus sodium:glucose cotransporter 2 0.0148 0.324 0.5625
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.1468 0.2517
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0017 0.024 0.0991
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.2202 0.4697
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0235 0.0304
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0572 0.0943
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0593 0.0404
Trypanosoma brucei glucose transporter, putative 0.0032 0.0602 0.4098
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.2602 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0235 0.0375
Loa Loa (eye worm) hypothetical protein 0.0015 0.0197 0.0339
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0879 0.1482
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0235 0.1015
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0209 0.4642 0.8085
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0592 0.1198
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0547 0.09
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0235 0.0304
Echinococcus granulosus solute carrier family 22 0.0015 0.0197 0.0286
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0602 0.3185
Schistosoma mansoni lipoxygenase 0.0257 0.5734 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0062 0.005
Schistosoma mansoni glucose transporter 0.0015 0.0197 0.0307
Trypanosoma cruzi prolyl endopeptidase 0.0017 0.024 0.0339
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0235 0.0304
Onchocerca volvulus 0.0038 0.0723 0.1184
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0602 0.2613
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0017 0.024 0.1696
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0009 0.0062 0.005
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0696 0.4742
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0314 0.0486
Echinococcus multilocularis acylamino acid releasing enzyme 0.0017 0.024 0.0361
Schistosoma mansoni hypothetical protein 0.0067 0.1397 0.2407
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0942 0.076
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.2202 0.3804
Schistosoma mansoni hypothetical protein 0.0031 0.0572 0.0963
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0235 0.1603
Mycobacterium ulcerans sugar transporter 0.0015 0.0197 0.1115
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0856 0.5709
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0972 0.1665
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0197 0.1115
Loa Loa (eye worm) hypothetical protein 0.0013 0.0156 0.025
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.2602 1
Schistosoma mansoni rab6-interacting 0.0043 0.0843 0.1438
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.1338 0.2305
Brugia malayi Sugar transporter family protein 0.0015 0.0197 0.0339
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0572 0.1153
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0394 0.2684
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.2602 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0592 0.1198
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0942 0.5858
Trypanosoma brucei oligopeptidase b 0.0017 0.024 0.1633
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0856 0.5183
Trypanosoma brucei glucose transporter, putative 0.0032 0.0602 0.4098
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0235 0.0296
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0235 0.1603
Brugia malayi major facilitator superfamily protein 0.0015 0.0197 0.0339
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0394 0.0653
Schistosoma mansoni glucose transport protein 0.0105 0.225 0.3901
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.2202 0.3804
Schistosoma mansoni serine/threonine protein kinase 0.0008 0.0041 0.0034
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0394 0.5182
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0197 0.0286
Loa Loa (eye worm) hypothetical protein 0.0043 0.0843 0.1742
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0197 0.0798
Brugia malayi Cyclic-nucleotide gated cation channel 0.0009 0.0062 0.0046
Loa Loa (eye worm) hypothetical protein 0.0015 0.0197 0.0339
Trypanosoma brucei glucose transporter, putative 0.0032 0.0602 0.4098
Echinococcus granulosus cGMP dependent protein kinase 0.0008 0.0041 0.0012
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0235 0.0039
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0394 0.0632
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0856 0.3752
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0942 0.1593
Brugia malayi hypothetical protein 0.0016 0.0223 0.0396
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0593 0.084
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0843 0.1419
Echinococcus granulosus solute carrier family 5 0.0148 0.324 0.5625
Echinococcus multilocularis solute carrier family 22 0.0015 0.0197 0.0286
Schistosoma mansoni inositol monophosphatase 0.0044 0.0856 0.1461
Echinococcus granulosus solute carrier family 22 0.0015 0.0197 0.0286
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0723 0.1039
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0602 0.2613
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0008 0.0041 0.0012
Schistosoma mansoni hypothetical protein 0.0011 0.0112 0.0159
Schistosoma mansoni sodium/solute symporter 0.0038 0.0723 0.1229
Plasmodium vivax hypothetical protein, conserved 0.0017 0.024 0.0044
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.2602 1
Leishmania major hypothetical protein, conserved 0.0025 0.0422 0.2668
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.2326 0.8856
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.1468 0.2517
Toxoplasma gondii protein kinase, putative 0.0295 0.661 1
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0572 0.1153
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0602 0.2613
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0009 0.0062 0.005
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.225 0.3888
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0197 0.0339
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Echinococcus multilocularis cpg binding protein 0.0032 0.0597 0.0988
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0422 0.0382
Trypanosoma brucei prolyl endopeptidase 0.0017 0.024 0.1633
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0017 0.024 0.1393
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0062 0.0072
Schistosoma mansoni voltage-gated potassium channel 0.0013 0.0156 0.0235
Loa Loa (eye worm) hypothetical protein 0.0054 0.1089 0.2279
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.225 0.3362
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0017 0.024 0.0179
Leishmania major glucose transporter, lmgt3 0.0032 0.0602 0.3929
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0197 0.0798
Loa Loa (eye worm) hypothetical protein 0.0015 0.0197 0.0339
Plasmodium falciparum peptidase, putative 0.0017 0.024 0.02
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0812 0.3555
Echinococcus multilocularis solute carrier family 5 0.0148 0.324 0.5625
Loa Loa (eye worm) hypothetical protein 0.0025 0.0443 0.0874
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0062 0.0072
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0394 0.1552
Schistosoma mansoni polycystin 1-related 0.0043 0.0843 0.1438
Loa Loa (eye worm) hypothetical protein 0.0015 0.0197 0.0339
Mycobacterium tuberculosis Probable reductase 0.0108 0.2326 0.8856
Trypanosoma cruzi oligopeptidase b 0.0017 0.024 0.0339
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0235 0.1362
Onchocerca volvulus 0.0043 0.0843 0.1453
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0062 0.005
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0394 0.0355
Loa Loa (eye worm) glutathione reductase 0.0047 0.0942 0.1958
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0235 0.0304
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0062 0.0072
Leishmania major protein kinase, putative 0.0032 0.0592 0.3863

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 21 % Displacement of [3H]-dofetilide from hERG at 10 uM ChEMBL. 17977724
Activity (binding) = 21 % Displacement of [3H]-dofetilide from hERG at 10 uM ChEMBL. 17977724
IC50 (binding) = 1.1 nM Inhibition of human DPP4 ChEMBL. 17977724
IC50 (binding) = 1.1 nM Inhibition of human DPP4 ChEMBL. 17977724
IC50 = 28900 nM Inhibition of hERG by patch clamp assay ChEMBL. 17977724
IC50 = 28900 nM Inhibition of hERG by patch clamp assay ChEMBL. 17977724
IC50 (binding) = 346 uM Inhibition of human DPP8 ChEMBL. 17977724
IC50 (binding) = 346 uM Inhibition of human DPP8 ChEMBL. 17977724

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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