TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 453.019 | Formula: C26H33ClN4O
H donors: 3 H acceptors: 1 LogP: 4.64 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CC(N1CCC(CC1)CNC[C@@H](c1ccccc1)NC(=O)c1ccc2c(c1)[nH]cc2Cl)C
InChi: 1S/C26H33ClN4O/c1-18(2)31-12-10-19(11-13-31)15-28-17-25(20-6-4-3-5-7-20)30-26(32)21-8-9-22-23(27)16-29-24(22)14-21/h3-9,14,16,18-19,25,28-29H,10-13,15,17H2,1-2H3,(H,30,32)/t25-/m0/s1
InChiKey: XQGIURLDQVHECN-VWLOTQADSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	GTP-binding protein, putative	0.0021	0.0066	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0361	0.1631
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0185	0.0968
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0148	0.0999	0.4489
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0037	0.0185	1
Trichomonas vaginalis	ran, putative	0.0021	0.0066	0.0318
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0053	0.0306	0.133
Schistosoma mansoni	ferritin	0.0017	0.0038	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0171	0.0737
Schistosoma mansoni	hypothetical protein	0.008	0.0499	0.0486
Schistosoma mansoni	ferritin	0.0017	0.0038	0.0023
Onchocerca volvulus		0.0107	0.0702	0.596
Schistosoma mansoni	hypothetical protein	0.0303	0.2142	0.2131
Echinococcus granulosus	TRP transient receptor potential channel	0.0036	0.0178	0.0164
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.1828	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0107	0.0702	0.3796
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0258	0.0258
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0177	0.0164
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0107	0.0702	0.3235
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0686	0.4959	0.5235
Onchocerca volvulus		0.0081	0.051	0.4297
Schistosoma mansoni	apoferritin-2	0.0017	0.0038	0.0023
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0034	0.0164	0.0158
Entamoeba histolytica	hypothetical protein	0.0023	0.0082	0.117
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0157	0.0165
Echinococcus multilocularis	short transient receptor potential channel 6	0.0064	0.0385	0.0371
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0093	0.0594	0.0581
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0066	0.0052
Schistosoma mansoni	ferritin	0.0017	0.0038	0.0023
Mycobacterium ulcerans	chorismate mutase	0.0463	0.332	0.3495
Schistosoma mansoni	ran	0.0021	0.0066	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0154	0.066
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0157	0.0165
Schistosoma mansoni	cpg binding protein	0.0057	0.0335	0.0322
Brugia malayi	beta-lactamase family protein	0.0107	0.0702	0.3796
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.1237	0.6752
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0107	0.0702	0.0689
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0093	0.0594	0.502
Trichomonas vaginalis	D-aminoacylase, putative	0.0107	0.0702	0.3815
Mycobacterium ulcerans	hypothetical protein	0.0164	0.1121	0.1171
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0037	0.0185	0.0171
Brugia malayi	MH2 domain containing protein	0.012	0.0798	0.4322
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0034	0.0164	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0702	0.3235
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0171	0.2277
Brugia malayi	serine/threonine-protein kinase plk-2	0.0093	0.0594	0.3197
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0201	0.0879
Toxoplasma gondii	hypothetical protein	0.005	0.0283	0.3842
Mycobacterium tuberculosis	Probable hydrolase	0.0107	0.0702	0.0742
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0014	0.0018	0.0004
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0037	0.0185	0.0777
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.1828	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0082	0.0404
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0252	0.1766	0.8232
Trichomonas vaginalis	D-aminoacylase, putative	0.0107	0.0702	0.3815
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0258	0.0273
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0066	0.0245
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0044	0.0235	0.1009
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0121	0.0489
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0258	0.0258
Brugia malayi	intermediate filament protein	0.0081	0.051	0.2737
Leishmania major	hypothetical protein, conserved	0.0107	0.0702	0.3138
Schistosoma mansoni	transient receptor potential channel	0.0064	0.0385	0.0371
Loa Loa (eye worm)	branched-chain amino acid aminotransferase	0.0092	0.059	0.2706
Schistosoma mansoni	transient receptor potential channel 4	0.0097	0.0627	0.0614
Schistosoma mansoni	hypothetical protein	0.0172	0.1179	0.1167
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0082	0.0404
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0303	0.2142	1
Brugia malayi	Branched-chain amino acid aminotransferase, cytosolic, putative	0.0092	0.059	0.3174
Brugia malayi	exodeoxyribonuclease III family protein	0.0037	0.0185	0.094
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0258	0.1346
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0185	0.0777
Entamoeba histolytica	hypothetical protein	0.0036	0.0177	0.2817
Mycobacterium ulcerans	bacterioferritin BfrB	0.0017	0.0038	0.0025
Onchocerca volvulus		0.0018	0.0042	0.0244
Trypanosoma brucei	polo-like protein kinase	0.0093	0.0594	0.2644
Echinococcus granulosus	short transient receptor potential channel 6	0.0064	0.0385	0.0371
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0258	0.1113
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.008	0.0499	0.0486
Entamoeba histolytica	hypothetical protein	0.0036	0.0177	0.2817
Echinococcus granulosus	transient receptor potential ion channel A	0.0094	0.0603	0.059
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0122	0.0809	0.0796
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0235	0.1009
Mycobacterium ulcerans	hypothetical protein	0.0107	0.0702	0.0728
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0258	0.0258
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0594	0.3219
Echinococcus granulosus	beta LACTamase domain containing family member	0.0107	0.0702	0.0689
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0177	0.0164
Loa Loa (eye worm)	beta-lactamase	0.0107	0.0702	0.3235
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0038	0.0193	0.0189
Echinococcus multilocularis	transient receptor potential gamma protein	0.0097	0.0627	0.0614
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0812	0.5881	0.5875
Schistosoma mansoni	ap endonuclease	0.0037	0.0185	0.0171
Echinococcus multilocularis	musashi	0.0081	0.051	0.0497
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0038	0.0193	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0038	0.0193	0.1016
Loa Loa (eye worm)	latrophilin receptor protein 2	0.008	0.0499	0.2279
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0014	0.0014	0.0015
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0107	0.0702	0.0728
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.1828	1
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.1828	1
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0036	0.0178	0.0164
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0312	0.2208	1
Mycobacterium ulcerans	branched-chain amino acid aminotransferase	0.0092	0.059	0.0609
Schistosoma mansoni	cpg binding protein	0.0061	0.0359	0.0346
Onchocerca volvulus	Glucosylceramidase homolog	0.0171	0.1169	1
Mycobacterium tuberculosis	Conserved protein	0.0107	0.0702	0.0742
Echinococcus multilocularis	snurportin 1	0.0303	0.2142	0.2131
Mycobacterium tuberculosis	Conserved protein	0.0107	0.0702	0.0742
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0193	0.0817
Trypanosoma cruzi	hypothetical protein, conserved	0.0107	0.0702	0.3138
Echinococcus multilocularis	expressed protein	0.0017	0.0038	0.0023
Giardia lamblia	Hypothetical protein	0.0026	0.0107	0.0771
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0178	0.0772
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0014	0.0014	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0171	0.0737
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0014	0.0015
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0044	0.0235	0.1009
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0035	0.0171	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.025	0.1328
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0082	0.0404
Trichomonas vaginalis	branched-chain amino acid aminotransferase, putative	0.0092	0.059	0.3196
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0121	0.156
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0258	0.0258
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0093	0.0594	1
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0014	0.0014	0.0015
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0014	0.0014	0.0015
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0014	0.0015
Mycobacterium ulcerans	lipase LipD	0.0107	0.0702	0.0728
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0044	0.0233	0.1028
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.008	0.0499	0.0486
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0066	0.0238
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0138	0.0928	0.0915
Schistosoma mansoni	ran	0.0021	0.0066	0.0052
Brugia malayi	RNA, U transporter 1	0.0081	0.0506	0.2715
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0627	0.288
Schistosoma mansoni	hypothetical protein	0.0504	0.3619	0.361
Echinococcus multilocularis	geminin	0.0504	0.3619	0.361
Trypanosoma brucei	hypothetical protein, conserved	0.0107	0.0702	0.3138
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0138	0.0928	0.0915
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.0798	0.3684
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0014	0.0018	0.0004
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0193	0.0179
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0014	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0702	0.3235
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0594	0.3219
Echinococcus granulosus	lamin	0.0081	0.051	0.0497
Brugia malayi	beta-lactamase	0.0107	0.0702	0.3796
Mycobacterium leprae	Probable lipase LipE	0.0107	0.0702	0.0728
Trichomonas vaginalis	penicillin-binding protein, putative	0.0107	0.0702	0.3815
Schistosoma mansoni	hypothetical protein	0.0504	0.3619	0.361
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0093	0.0594	0.0581
Brugia malayi	Importin beta-1 subunit	0.0028	0.0121	0.0592
Brugia malayi	Latrophilin receptor protein 2	0.008	0.0499	0.2673
Brugia malayi	Transient-receptor-potential like protein	0.0036	0.0178	0.0905
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.1169	0.638
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0185	1
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.1828	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0157	0.0165
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0258	0.0273
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0035	0.0171	0.0166
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0594	0.3219
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0107	0.0702	0.0742
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0093	0.0594	0.2644
Entamoeba histolytica	hypothetical protein	0.0036	0.0177	0.2817
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.1169	0.638
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0014	0.0018	0.0004
Onchocerca volvulus		0.0057	0.0335	0.2781
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0312	0.2208	1
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0017	0.0038	0.004
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0258	0.0258
Schistosoma mansoni	ferritin	0.0017	0.0038	0.0023
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0066	0.0759
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0258	0.1147
Mycobacterium tuberculosis	Probable esterase LipL	0.0107	0.0702	0.0742
Loa Loa (eye worm)	inositol-1	0.0038	0.0193	0.0842
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0193	0.0179
Echinococcus multilocularis	lamin	0.0081	0.051	0.0497
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0107	0.0702	0.0689
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0702	0.3235
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0185	0.2476
Toxoplasma gondii	Branched-chain-amino-acid aminotransferase	0.0092	0.059	0.8232
Schistosoma mansoni	lamin	0.0081	0.051	0.0497
Echinococcus multilocularis	inositol monophosphatase 1	0.0038	0.0193	0.0179
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0018	0.0043	0.0029
Echinococcus multilocularis	lamin dm0	0.0081	0.051	0.0497
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0121	0.1535
Trichomonas vaginalis	D-aminoacylase, putative	0.0107	0.0702	0.3815
Mycobacterium ulcerans	beta-lactamase	0.0107	0.0702	0.0728
Toxoplasma gondii	hypothetical protein	0.0026	0.0107	0.1329
Loa Loa (eye worm)	hypothetical protein	0.0252	0.1766	0.8232
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0148	0.0999	0.4489
Schistosoma mansoni	lamin	0.0081	0.051	0.0497
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.008	0.0499	0.0486
Mycobacterium ulcerans	bacterioferritin BfrA	0.0017	0.0038	0.0025
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0047	0.0258	0.0258
Trichomonas vaginalis	penicillin-binding protein, putative	0.0107	0.0702	0.3815
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0594	0.3219
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0193	0.0817
Trichomonas vaginalis	antibiotic synthetase, putative	0.0014	0.0014	0.0031
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0258	0.0258
Echinococcus multilocularis	ferritin	0.0017	0.0038	0.0023
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0107	0.0702	0.0742
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0121	0.0108
Mycobacterium ulcerans	hypothetical protein	0.13	0.9473	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0109	0.0713	1
Leishmania major	branched-chain amino acid aminotransferase, putative	0.0092	0.059	0.2625
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0258	0.1147
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0185	0.0968
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0037	0.0185	0.2241
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0171	0.0737
Schistosoma mansoni	intermediate filament proteins	0.0081	0.051	0.0497
Entamoeba histolytica	branched-chain amino acid aminotransferase, putative	0.0092	0.059	0.9928
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0177	0.0164
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.1169	0.638
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0014	0.0014	0.0015
Loa Loa (eye worm)	hypothetical protein	0.008	0.05	0.2282
Schistosoma mansoni	cpg binding protein	0.0061	0.0359	0.0346
Trypanosoma brucei	branched-chain amino acid aminotransferase, putative	0.0092	0.059	0.2625
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0252	0.1766	0.9657
Trichomonas vaginalis	glucosylceramidase, putative	0.026	0.1828	1
Mycobacterium tuberculosis	Conserved protein	0.0107	0.0702	0.0742
Brugia malayi	Inositol-1	0.0038	0.0193	0.0988
Trypanosoma cruzi	hypothetical protein, conserved	0.0107	0.0702	0.3138
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0066	0.3064
Schistosoma mansoni	importin beta-1	0.0028	0.0121	0.0108
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0038	0.0193	0.2563
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0258	0.1113
Loa Loa (eye worm)	hypothetical protein	0.0038	0.019	0.0828
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0037	0.0185	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0702	0.3235
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0039	0.0201	0.0187
Onchocerca volvulus		0.0107	0.0702	0.596
Leishmania major	mitochondrial DNA polymerase beta	0.0312	0.2208	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0018	0.0042	0.0152
Mycobacterium ulcerans	4-amino-4-deoxychorismate lyase	0.0026	0.0107	0.0098
Loa Loa (eye worm)	hypothetical protein	0.008	0.0499	0.2279
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0107	0.0702	0.0742
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0014	0.0014	0.0015
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0138	0.0928	0.5037
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0066	0.0238
Trypanosoma brucei	branched-chain amino acid aminotransferase, putative	0.0092	0.059	0.2625
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0014	0.0018	0.0004
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0258	0.1113
Loa Loa (eye worm)	hypothetical protein	0.0172	0.1179	0.5476
Schistosoma mansoni	apoferritin-2	0.0017	0.0038	0.0023
Trichomonas vaginalis	ferritin, putative	0.0017	0.0038	0.016
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.0594	0.2644
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0037	0.0185	0.9438
Echinococcus granulosus	expressed protein	0.0017	0.0038	0.0023
Trypanosoma brucei	Aminotransferase class IV, putative	0.0026	0.0107	0.0424
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0037	0.0185	0.018
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0258	0.4209
Mycobacterium tuberculosis	Branched-chain amino acid transaminase IlvE	0.0092	0.059	0.0623
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.008	0.0499	0.2673
Echinococcus multilocularis	microtubule associated protein 2	0.1372	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.018	0.1237	0.6752
Onchocerca volvulus		0.0107	0.0702	0.596
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0082	0.0309
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0044	0.0235	0.1009
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.1169	0.638
Echinococcus granulosus	lamin dm0	0.0081	0.051	0.0497
Plasmodium falciparum	importin beta, putative	0.0028	0.0121	0.6298
Echinococcus granulosus	intermediate filament protein	0.0081	0.051	0.0497
Mycobacterium leprae	Conserved hypothetical protein	0.13	0.9473	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0148	0.0999	0.4489
Mycobacterium leprae	PROBABLE BRANCHED-CHAIN AMINO ACID TRANSAMINASE ILVE	0.0092	0.059	0.0609
Echinococcus granulosus	geminin	0.0504	0.3619	0.361
Brugia malayi	cytoplasmic intermediate filament protein	0.0044	0.0233	0.1206
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0066	0.0052
Schistosoma mansoni	ferritin light chain	0.0017	0.0038	0.0023
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.026	0.1828	1
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0258	0.1346
Trypanosoma brucei	branched-chain amino acid aminotransferase, putative	0.0092	0.059	0.2625
Schistosoma mansoni	transient receptor potential channel	0.0064	0.0385	0.0371
Mycobacterium tuberculosis	Probable lipase LipE	0.0107	0.0702	0.0742
Giardia lamblia	Kinase, PLK	0.0093	0.0594	1
Giardia lamblia	Branched-chain amino acid aminotransferase lateral transfer candidate	0.0092	0.059	0.9921
Echinococcus granulosus	short transient receptor potential channel 6	0.0064	0.0385	0.0371
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.026	0.1828	0.8524
Echinococcus granulosus	snurportin 1	0.0303	0.2142	0.2131
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0066	0.0288
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0138	0.0928	0.0915
Mycobacterium leprae	conserved hypothetical protein	0.0107	0.0702	0.0728
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.0798	0.3684
Toxoplasma gondii	ABC1 family protein	0.0107	0.0702	0.9843
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0594	0.3219
Brugia malayi	Intermediate filament tail domain containing protein	0.0081	0.051	0.2737
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.0594	0.2644
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0171	0.0737
Schistosoma mansoni	transient receptor potential channel	0.0097	0.0627	0.0614
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0171	0.9194
Echinococcus granulosus	transient receptor potential gamma protein	0.0097	0.0627	0.0614
Plasmodium falciparum	aminodeoxychorismate lyase	0.0026	0.0107	0.5451
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0258	0.0258
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0081	0.051	0.2333
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0138	0.0928	0.4294
Echinococcus granulosus	inositol monophosphatase 1	0.0038	0.0193	0.0179
Echinococcus multilocularis	short transient receptor potential channel 6	0.0064	0.0385	0.0371
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0171	0.018
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.1169	0.638
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0702	0.3235
Mycobacterium tuberculosis	Chorismate mutase	0.13	0.9473	1
Brugia malayi	CXXC zinc finger family protein	0.0057	0.0335	0.1771
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0164	0.1121	0.1184
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0037	0.0185	0.0171
Onchocerca volvulus		0.0047	0.0258	0.2113
Plasmodium vivax	hypothetical protein, conserved	0.0107	0.0702	1
Loa Loa (eye worm)	intermediate filament protein	0.0081	0.051	0.2333
Mycobacterium tuberculosis	Probable oxidoreductase	0.0278	0.1956	0.2065
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0138	0.0928	0.0915
Schistosoma mansoni	microtubule-associated protein tau	0.1372	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0093	0.0594	0.0581
Schistosoma mansoni	hypothetical protein	0.0036	0.0177	0.0164
Trichomonas vaginalis	antibiotic synthetase, putative	0.0014	0.0014	0.0031
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0121	0.0489
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.1169	0.638
Mycobacterium ulcerans	esterase/lipase LipP	0.0107	0.0702	0.0728
Leishmania major	hypothetical protein, conserved	0.0026	0.0107	0.0424
Schistosoma mansoni	kinase	0.0047	0.0259	0.0245
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0193	0.1016
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0107	0.0702	0.0689
Echinococcus granulosus	ferritin	0.0017	0.0038	0.0023
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0014	0.0014	0.0015
Loa Loa (eye worm)	histone methyltransferase	0.0018	0.0043	0.0138
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0258	0.4209
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0258	0.1346
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0138	0.0928	0.0915
Schistosoma mansoni	ferritin light chain	0.0017	0.0038	0.0023
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.008	0.0499	0.0486
Brugia malayi	latrophilin 2 splice variant baaae	0.0172	0.1179	0.6425
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0037	0.0185	0.0801
Trypanosoma cruzi	Aminotransferase class IV, putative	0.0026	0.0107	0.0424
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0057	0.0335	0.151
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0258	0.0258
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0138	0.0928	0.0915
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0017	0.0038	0.0025
Echinococcus multilocularis	cpg binding protein	0.0061	0.0359	0.0346
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0037	0.0185	0.0195
Echinococcus multilocularis	transient receptor potential ion channel A	0.0094	0.0603	0.059
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0093	0.0594	0.2726
Brugia malayi	beta-lactamase family protein	0.0107	0.0702	0.3796
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0138	0.0928	0.0915
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0038	0.0193	0.309
Mycobacterium tuberculosis	Probable amino acid aminotransferase	0.0026	0.0107	0.0113
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0033	0.0157	0.0165
Mycobacterium tuberculosis	Chorismate mutase	0.0463	0.332	0.3504
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0258	0.0258
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0252	0.1766	0.9657
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0193	0.1016
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0037	0.0185	0.294
Schistosoma mansoni	hypothetical protein	0.008	0.0499	0.0486
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0017	0.0038	0.004
Schistosoma mansoni	ap endonuclease	0.0037	0.0185	0.0171
Mycobacterium ulcerans	short chain dehydrogenase	0.0278	0.1956	0.2053
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0258	0.4209
Trichomonas vaginalis	esterase, putative	0.0107	0.0702	0.3815
Schistosoma mansoni	hypothetical protein	0.008	0.0499	0.0486
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0121	0.0108
Schistosoma mansoni	hypothetical protein	0.008	0.0499	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0258	0.1147
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0066	0.0238
Trichomonas vaginalis	glucosylceramidase, putative	0.0171	0.1169	0.638
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0171	0.0737
Trichomonas vaginalis	subgroup IIIi aminotransferase, putative	0.0092	0.059	0.3196
Brugia malayi	hypothetical protein	0.0036	0.0177	0.0901
Loa Loa (eye worm)	hypothetical protein	0.0038	0.019	0.0828
Toxoplasma gondii	exonuclease III APE	0.0037	0.0185	0.2437
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0014	0.0014	0.0015
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0082	0.0309
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.025	0.1328
Echinococcus multilocularis	GPCR, family 2	0.008	0.0499	0.0486
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0018	0.0043	0.0029
Mycobacterium tuberculosis	Probable lipase LipD	0.0107	0.0702	0.0742
Plasmodium vivax	aminodeoxychorismate lyase, putative	0.0026	0.0107	0.135
Loa Loa (eye worm)	hypothetical protein	0.0081	0.051	0.2333
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0702	0.3235
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0014	0.0018	0.0004
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0594	0.3219
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0193	0.0817
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0185	0.0777
Entamoeba histolytica	hypothetical protein	0.0036	0.0177	0.2817
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.0594	0.3219
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0312	0.2208	1
Echinococcus granulosus	cpg binding protein	0.0061	0.0359	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0121	0.0505
Entamoeba histolytica	Ran family GTPase	0.0021	0.0066	0.0901
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0193	0.0817
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0066	0.0747
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0039	0.0201	0.0187
Echinococcus granulosus	GPCR family 2	0.008	0.0499	0.0486
Onchocerca volvulus		0.0081	0.051	0.4297

Activities

Activity type	Activity value	Assay description	Source	Reference
Kapp (binding)	= 1200 10^6L/mol	Binding affinity to F10a	ChEMBL.	17881231
Kapp (binding)	= 1200 10^6L/mol	Binding affinity to F10a	ChEMBL.	17881231

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 462006