Detailed information for compound 47204

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 622.176 | Formula: C30H46ClN6O6-
  • H donors: 6 H acceptors: 6 LogP: 2.78 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 3
  • SMILES: COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)NC(=O)CC(CC(NC(=O)[C@H](Cc1c[nH]cn1)N)CC(C)C)O.[Cl-]
  • InChi: 1S/C30H46N6O6.ClH/c1-18(2)11-21(34-28(39)24(31)14-22-16-32-17-33-22)13-23(37)15-26(38)36-27(19(3)4)29(40)35-25(30(41)42-5)12-20-9-7-6-8-10-20;/h6-10,16-19,21,23-25,27,37H,11-15,31H2,1-5H3,(H,32,33)(H,34,39)(H,35,40)(H,36,38);1H/p-1/t21?,23?,24-,25+,27+;/m0./s1
  • InChiKey: NPMXEAJZYZAYGH-UEZMJICJSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Matrilysin homolog 0.0082 0.1657 0.2916
Echinococcus multilocularis geminin 0.0178 0.3958 0.3956
Schistosoma mansoni importin beta-1 0.003 0.0411 0.0399
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Leishmania major cathepsin L-like protease 0.0092 0.1897 0.6149
Schistosoma mansoni cathepsin S (C01 family) 0.002 0.0175 0.0162
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0092 0.1897 1
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Trypanosoma cruzi major cysteine proteinase, putative 0.002 0.0175 0.05
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0049 0.0072
Onchocerca volvulus 0.002 0.0175 0.0303
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0364 0.0489
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0175 0.0303
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.1202 0.1614
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0453 0.044
Schistosoma mansoni cathepsin C 0.002 0.0175 0.0162
Echinococcus multilocularis lamin dm0 0.0028 0.0364 0.0361
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0219 0.0239
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.006 0.01
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0969 0.0967
Brugia malayi cahepsin L-like non-peptiedase homolog 0.002 0.0175 0.0328
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0669 0.1175
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0969 0.2806
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0969 0.0967
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0136 0.0234
Echinococcus granulosus cathepsin l1 0.0063 0.1199 0.1197
Trichomonas vaginalis chromobox protein, putative 0.0073 0.1441 0.2536
Onchocerca volvulus Matrilysin homolog 0.0037 0.0574 0.1006
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0453 0.1613
Onchocerca volvulus 0.0092 0.1897 0.334
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0063 0.1187 0.3438
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0029 0.0382 0.0748
Leishmania major GTP-binding protein, putative 0.0022 0.0219 0.0702
Echinococcus multilocularis cysteine protease 0.0092 0.1897 0.1895
Schistosoma mansoni hypothetical protein 0.0031 0.0419 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0382 0.0667
Brugia malayi Cathepsin L-like precursor 0.0092 0.1897 0.3818
Schistosoma mansoni hypothetical protein 0.0053 0.0945 0.0933
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0219 0.0418
Onchocerca volvulus 0.0028 0.0364 0.0637
Echinococcus granulosus intermediate filament protein 0.0028 0.0364 0.0361
Onchocerca volvulus Matrix metalloproteinase homolog 0.0082 0.1657 0.2916
Echinococcus granulosus chromobox protein 1 0.0073 0.1441 0.1439
Brugia malayi intermediate filament protein 0.0028 0.0364 0.0712
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.3447 0.3438
Echinococcus multilocularis cpg binding protein 0.0032 0.045 0.0447
Brugia malayi cathepsin F-like cysteine proteinase 0.0029 0.0382 0.0748
Loa Loa (eye worm) hypothetical protein 0.003 0.0411 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0566 0.0993
Leishmania major hypothetical protein, conserved 0.0027 0.032 0.1028
Leishmania major importin beta-1 subunit, putative 0.0025 0.0274 0.0879
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0744 0.1306
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0411 0.067
Trichomonas vaginalis chromobox protein, putative 0.0073 0.1441 0.2536
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0873 0.2283
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.002 0.0175 0.0162
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0364 0.0489
Toxoplasma gondii cathepsin CPL 0.0092 0.1897 1
Schistosoma mansoni hypothetical protein 0.0178 0.3958 0.395
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0274 0.0478
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0175 0.0303
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0615 0.0826
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0092 0.1897 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0157 0.3447 0.6957
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Echinococcus multilocularis conserved hypothetical protein 0.0111 0.2343 0.2341
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Trypanosoma cruzi major cysteine proteinase, putative 0.007 0.1362 0.3946
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0175 0.0328
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0274 0.0478
Brugia malayi PHD-finger family protein 0.0031 0.0419 0.0823
Brugia malayi Bromodomain containing protein 0.0031 0.0419 0.0823
Onchocerca volvulus 0.0092 0.1897 0.334
Echinococcus granulosus snurportin 1 0.0324 0.7448 0.7447
Brugia malayi Cathepsin L-like precursor 0.0029 0.0382 0.0748
Onchocerca volvulus Cathepsin L homolog 0.002 0.0175 0.0303
Onchocerca volvulus 0.003 0.0409 0.0715
Onchocerca volvulus Alhambra homolog 0.0031 0.0419 0.0734
Schistosoma mansoni intermediate filament proteins 0.0028 0.0364 0.0352
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0004
Echinococcus granulosus cpg binding protein 0.0032 0.045 0.0447
Plasmodium falciparum cysteine proteinase falcipain 1 0.005 0.0873 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0175 0.0303
Trypanosoma cruzi cruzipain precursor, putative 0.0142 0.3084 0.8947
Schistosoma mansoni ran 0.0022 0.0219 0.0207
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0969 0.0957
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0015 0.0034
Loa Loa (eye worm) hypothetical protein 0.0029 0.0382 0.0514
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0175 0.0303
Trypanosoma cruzi cysteine protease, putative 0.005 0.0873 0.2527
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0969 0.2806
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0744 0.1306
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0669 0.1175
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0035 0.0529 0.0517
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0045 0.0767 0.1528
Entamoeba histolytica hypothetical protein 0.0025 0.0274 0.0573
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0566 0.1635
Loa Loa (eye worm) matrix metalloproteinase 0.0037 0.0574 0.077
Echinococcus granulosus single minded 2 0.0038 0.0592 0.0589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0235
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0592 0.1173
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0235
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0969 0.1302
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0969 0.1704
Loa Loa (eye worm) hypothetical protein 0.0092 0.1897 0.2548
Trichomonas vaginalis ran, putative 0.0022 0.0219 0.0382
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Schistosoma mansoni ran 0.0022 0.0219 0.0207
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0092 0.1897 0.334
Echinococcus granulosus transcription factor btf3 0.0037 0.0566 0.0563
Loa Loa (eye worm) hypothetical protein 0.0028 0.0364 0.0489
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0453 0.045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Brugia malayi RNA, U transporter 1 0.0086 0.1752 0.3523
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0175 0.0303
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0175 0.0162
Leishmania major protein kinase, putative 0.0014 0.0015 0.0038
Loa Loa (eye worm) hypothetical protein 0.0037 0.0574 0.077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0175 0.0303
Echinococcus multilocularis importin subunit beta 1 0.003 0.0411 0.0408
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.032 0.0841
Schistosoma mansoni hypothetical protein 0.0054 0.0989 0.0977
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0175 0.0303
Brugia malayi Cathepsin L-like cysteine proteinase 0.0063 0.1199 0.2403
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0382 0.0667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Trypanosoma cruzi cysteine peptidase, putative 0.0142 0.3084 0.8947
Giardia lamblia PHD finger protein 15 0.0031 0.0419 0.2415
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.005 0.0873 0.2527
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.032 0.0841
Leishmania major basic transcription factor 3a, putative 0.0037 0.0566 0.1827
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0219 0.0257
Schistosoma mansoni cpg binding protein 0.003 0.0409 0.0396
Plasmodium vivax vivapain-1 0.005 0.0873 0.3769
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0274 0.0786
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0969 0.2806
Schistosoma mansoni cpg binding protein 0.0032 0.045 0.0437
Loa Loa (eye worm) hypothetical protein 0.0029 0.0382 0.0514
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0175 0.0162
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0136 0.0234
Leishmania major protein kinase, putative 0.0014 0.0015 0.0038
Onchocerca volvulus 0.0092 0.1897 0.334
Echinococcus granulosus cathepsin b 0.0157 0.3447 0.3445
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Loa Loa (eye worm) hypothetical protein 0.0063 0.1199 0.161
Echinococcus multilocularis transcription factor btf3 0.0037 0.0566 0.0563
Loa Loa (eye worm) hypothetical protein 0.0093 0.1907 0.256
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0219 0.0216
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0175 0.0303
Brugia malayi CXXC zinc finger family protein 0.003 0.0409 0.0801
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0419 0.0417
Onchocerca volvulus 0.0044 0.074 0.13
Plasmodium vivax vivapain-2 0.0092 0.1897 0.9297
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0175 0.0328
Trypanosoma cruzi cysteine peptidase, putative 0.0142 0.3084 0.8947
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0175 0.0162
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Plasmodium falciparum importin beta, putative 0.003 0.0411 0.1372
Echinococcus multilocularis musashi 0.0028 0.0364 0.0361
Echinococcus granulosus cysteine protease 0.005 0.0873 0.0871
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0063 0.1199 0.2109
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0382 0.0514
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0969 0.1704
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0175 0.0235
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0969 0.1704
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0136 0.0234
Entamoeba histolytica cysteine proteinase 2 0.005 0.0873 0.4054
Leishmania major cathepsin L-like protease 0.0092 0.1897 0.6149
Onchocerca volvulus 0.0032 0.0456 0.0799
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.2092 0.209
Brugia malayi hypoxia-induced factor 1 0.0158 0.3481 0.7027
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0969 0.2806
Echinococcus granulosus cathepsin b 0.0157 0.3447 0.3445
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0615 0.0603
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0969 0.3136
Leishmania major cysteine peptidase A (CPA) 0.0092 0.1897 0.6149
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0037 0.0574 0.0561
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.3447 0.3438
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.032 0.0781
Onchocerca volvulus 0.0092 0.1897 0.334
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0453 0.045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0175 0.0303
Echinococcus multilocularis cathepsin L 0.002 0.0175 0.0172
Mycobacterium ulcerans hydrolase 0.0045 0.0767 1
Brugia malayi Matrixin family protein 0.009 0.1834 0.369
Echinococcus multilocularis snurportin 1 0.0324 0.7448 0.7447
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0219 0.0216
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0175 0.0328
Loa Loa (eye worm) hypothetical protein 0.0032 0.0453 0.0608
Schistosoma mansoni hypothetical protein 0.0324 0.7448 0.7444
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Brugia malayi MAP kinase sur-1 0.0054 0.0969 0.1937
Plasmodium vivax transporter, putative 0.0077 0.1537 0.735
Onchocerca volvulus 0.0037 0.0574 0.1006
Echinococcus multilocularis cathepsin b 0.0157 0.3447 0.3445
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0235
Onchocerca volvulus 0.0053 0.0945 0.1661
Brugia malayi hypothetical protein 0.0172 0.38 0.7673
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0873 0.1535
Brugia malayi Cathepsin L-like precursor 0.0092 0.1897 0.3818
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.002 0.0175 0.0303
Echinococcus granulosus importin subunit beta 1 0.003 0.0411 0.0408
Loa Loa (eye worm) hypothetical protein 0.0063 0.1199 0.161
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0175 0.0328
Brugia malayi cathepsin L-like precursor 0.0063 0.1199 0.2403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0409 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0669 0.1175
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0235
Brugia malayi Cathepsin L-like precursor 0.0063 0.1199 0.2403
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0453 0.044
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0136 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0173 0.0325
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0566 0.211
Mycobacterium leprae PROBABLE HYDROLASE 0.0045 0.0767 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0092 0.1897 0.1895
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0013 0.001
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.002 0.0175 0.0235
Echinococcus multilocularis cathepsin L cysteine protease 0.0092 0.1897 0.1895
Schistosoma mansoni chromobox protein 0.0073 0.1441 0.143
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0453 0.044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Loa Loa (eye worm) hypothetical protein 0.0032 0.0456 0.0613
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0013 0.001
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0419 0.1419
Echinococcus granulosus cathepsin l cysteine peptidase 0.0092 0.1897 0.1895
Brugia malayi jmjC domain containing protein 0.0039 0.0615 0.122
Leishmania major cathepsin L-like protease 0.0142 0.3084 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0015 0.0034
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0049 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0175 0.0303
Trypanosoma brucei protein kinase, putative 0.0054 0.0969 0.2618
Echinococcus multilocularis cysteine protease 0.0092 0.1897 0.1895
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0969 0.2618
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0136 0.0234
Loa Loa (eye worm) hypothetical protein 0.0027 0.032 0.043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0175 0.0303
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0003 0.5
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0566 0.2269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Echinococcus multilocularis lamin 0.0028 0.0364 0.0361
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0566 0.0993
Loa Loa (eye worm) fibroinase 0.0092 0.1897 0.2548
Brugia malayi cathepsin Z-like cysteine proteinase 0.002 0.0175 0.0328
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0873 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0873 0.4054
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Brugia malayi Cathepsin L-like precursor 0.0092 0.1897 0.3818
Brugia malayi Pre-SET motif family protein 0.0032 0.0453 0.0891
Onchocerca volvulus Cathepsin L homolog 0.0092 0.1897 0.334
Echinococcus granulosus lamin 0.0028 0.0364 0.0361
Giardia lamblia Cathepsin B precursor 0.0063 0.1187 1
Schistosoma mansoni transcription factor btf3 0.0037 0.0566 0.0554
Trypanosoma cruzi cysteine proteinase, putative 0.005 0.0873 0.2527
Loa Loa (eye worm) hypothetical protein 0.0063 0.1199 0.161
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0092 0.1897 0.2548
Schistosoma mansoni hypothetical protein 0.0178 0.3958 0.395
Loa Loa (eye worm) ctsf protein 0.0092 0.1897 0.2548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.005 0.0873 0.1535
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0157 0.3447 1
Brugia malayi beta-NAC-like protein 0.0037 0.0566 0.112
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0235
Giardia lamblia Cathepsin B precursor 0.0063 0.1187 1
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0045 0.0767 0.5
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0135 0.2918 0.2915
Entamoeba histolytica cysteine proteinase, putative 0.0092 0.1897 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0135 0.2918 0.2915
Brugia malayi cathepsin F-like cysteine proteinase 0.002 0.0175 0.0328
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0092 0.1897 0.1895
Giardia lamblia Cathepsin B precursor 0.0063 0.1187 1
Onchocerca volvulus 0.0092 0.1897 0.334
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0409 0.0549
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0707 0.0705
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0012 0.0009
Schistosoma mansoni single-minded 0.0051 0.0911 0.0899
Schistosoma mansoni cathepsin B (C01 family) 0.002 0.0175 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Trypanosoma cruzi cysteine peptidase, putative 0.0142 0.3084 0.8947
Leishmania major cathepsin L-like protease 0.0142 0.3084 1
Brugia malayi Matrixin family protein 0.0037 0.0574 0.1135
Brugia malayi Pre-SET motif family protein 0.022 0.4949 1
Brugia malayi fibroinase precursor 0.002 0.0175 0.0328
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0615 0.0613
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0219 0.0295
Echinococcus granulosus chromobox protein 1 0.0073 0.1441 0.1439
Loa Loa (eye worm) hypothetical protein 0.0172 0.38 0.5103
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0092 0.1897 0.2548
Plasmodium falciparum cysteine proteinase falcipain 3 0.0092 0.1897 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0352 0.0473
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0048 0.0079
Brugia malayi PAS domain containing protein 0.0051 0.0911 0.1819
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0132 0.0119
Leishmania major cathepsin L-like protease 0.0092 0.1897 0.6149
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0566 0.0993
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.1248 0.1237
Trypanosoma cruzi cysteine peptidase, putative 0.005 0.0873 0.2527
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0419 0.0563
Trypanosoma cruzi cysteine proteinase, putative 0.005 0.0873 0.2527
Brugia malayi hypothetical protein 0.0093 0.1907 0.3836
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0015 0.0034
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.4949 0.6645
Trypanosoma brucei cysteine peptidase C (CPC) 0.0063 0.1187 0.3378
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0969 0.3136
Onchocerca volvulus 0.0063 0.1199 0.2109
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0419 0.0407
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.005 0.0873 0.0861
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0364 0.0712
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0566 0.2269
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0219 0.0257
Onchocerca volvulus 0.0092 0.1897 0.334
Loa Loa (eye worm) matrixin family protein 0.009 0.1834 0.2463
Trichomonas vaginalis set domain proteins, putative 0.025 0.5674 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0063 0.1187 0.2088
Brugia malayi Matrixin family protein 0.0037 0.0574 0.1135
Entamoeba histolytica hypothetical protein 0.0037 0.0566 0.2269
Plasmodium falciparum phd finger protein, putative 0.0031 0.0419 0.1419
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Schistosoma mansoni eyes absent homolog 0.0093 0.1907 0.1896
Echinococcus multilocularis chromobox protein 1 0.0073 0.1441 0.1439
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0063 0.1199 0.2109
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0873 0.4054
Onchocerca volvulus 0.025 0.5674 1
Entamoeba histolytica cysteine proteinase 1, putative 0.005 0.0873 0.4054
Echinococcus granulosus peregrin 0.0031 0.0419 0.0417
Leishmania major cathepsin L-like protease 0.0092 0.1897 0.6149
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0566 0.076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Onchocerca volvulus 0.0028 0.0364 0.0637
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0873 0.1743
Plasmodium vivax hypothetical protein, conserved 0.0077 0.1537 0.735
Loa Loa (eye worm) hypothetical protein 0.0157 0.3447 0.4628
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0098 0.2028 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0453 0.045
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0175 0.0162
Plasmodium vivax unspecified product 0.0029 0.0382 0.1119
Brugia malayi Matrixin family protein 0.0037 0.0574 0.1135
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.7448 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.002 0.0175 0.0303
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0175 0.0235
Plasmodium vivax SET domain protein, putative 0.0032 0.0453 0.1499
Entamoeba histolytica cysteine proteinase, putative 0.0092 0.1897 1
Trypanosoma cruzi cysteine peptidase, putative 0.0092 0.1897 0.5501
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.032 0.092
Echinococcus multilocularis cathepsin b 0.0157 0.3447 0.3445
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.1441 0.1935
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0219 0.0628
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.005 0.0873 0.2283
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.002 0.0175 0.0303
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0411 0.067
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0419 0.1419
Onchocerca volvulus 0.0092 0.1897 0.334
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.032 0.092
Echinococcus granulosus cathepsin L cysteine proteinase 0.0092 0.1897 0.1895
Entamoeba histolytica cysteine protease, putative 0.0092 0.1897 1
Plasmodium vivax unspecified product 0.005 0.0873 0.3769
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0113 0.2386 0.6919
Schistosoma mansoni cathepsin F (C01 family) 0.0063 0.1199 0.1188
Echinococcus granulosus lamin dm0 0.0028 0.0364 0.0361
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.002 0.0175 0.0303
Brugia malayi SET domain containing protein 0.0014 0.0015 0.0005
Plasmodium vivax vivapain-3 0.005 0.0873 0.3769
Loa Loa (eye worm) hypothetical protein 0.0045 0.0767 0.103
Schistosoma mansoni jumonji domain containing protein 0.008 0.1597 0.1586
Trypanosoma cruzi cruzipain precursor, putative 0.0029 0.0382 0.1102
Loa Loa (eye worm) hypothetical protein 0.0037 0.0574 0.077
Brugia malayi Papain family cysteine protease containing protein 0.0092 0.1897 0.3818
Loa Loa (eye worm) hypothetical protein 0.0053 0.0945 0.1269
Loa Loa (eye worm) hypoxia-induced factor 1 0.0158 0.3481 0.4675
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0969 0.1704
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0175 0.0162
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.2092 0.209
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0969 0.4611
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0744 0.1306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Plasmodium vivax vivapain-2 0.0092 0.1897 0.9297
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0969 0.0967
Onchocerca volvulus 0.0038 0.0592 0.1039
Echinococcus multilocularis cathepsin L cysteine protease 0.0092 0.1897 0.1895
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0911 0.0899
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Loa Loa (eye worm) cysteine protease 0.0092 0.1897 0.2548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Plasmodium vivax importin-beta 2, putative 0.003 0.0411 0.1275
Echinococcus multilocularis cathepsin L 0.005 0.0873 0.0871
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Echinococcus granulosus cathepsin l1 0.0092 0.1897 0.1895
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0175 0.0303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.032 0.0351
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0092 0.1897 0.334
Brugia malayi Matrixin family protein 0.0037 0.0574 0.1135
Brugia malayi cathepsin L-like cysteine proteinase 0.002 0.0175 0.0328
Entamoeba histolytica cysteine proteinase, putative 0.005 0.0873 0.4054
Schistosoma mansoni cathepsin s 0.0029 0.0382 0.037
Loa Loa (eye worm) hypothetical protein 0.0041 0.0669 0.0899
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0411 0.1372
Echinococcus granulosus cathepsin L 0.005 0.0873 0.0871
Echinococcus granulosus cathepsin L 0.002 0.0175 0.0172
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0615 0.0603
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0566 0.2269
Leishmania major cathepsin L-like protease 0.0142 0.3084 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0063 0.1187 0.1175
Brugia malayi Importin beta-1 subunit 0.003 0.0411 0.0807
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.005 0.0873 0.0861
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Loa Loa (eye worm) hypothetical protein 0.0037 0.0574 0.077
Brugia malayi hypothetical protein 0.0027 0.032 0.0622
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0969 0.0967
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0707 0.0705
Trypanosoma cruzi cysteine peptidase, putative 0.0029 0.0382 0.1102
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Leishmania major cathepsin L-like protease 0.0092 0.1897 0.6149
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.1084 0.5278
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0219 0.0438
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0017
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0574 0.0571
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0092 0.1897 0.334
Brugia malayi Cathepsin L-like precursor 0.0092 0.1897 0.3818
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0136 0.0234
Brugia malayi jmjC domain containing protein 0.01 0.2092 0.4213
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0015 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.3084 1
Echinococcus granulosus geminin 0.0178 0.3958 0.3956
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0175 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Onchocerca volvulus Cathepsin F homolog 0.0092 0.1897 0.334
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.002 0.0175 0.0303
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0382 0.0514
Onchocerca volvulus Cathepsin L homolog 0.0092 0.1897 0.334
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.006 0.01
Echinococcus multilocularis peregrin 0.0031 0.0419 0.0417
Loa Loa (eye worm) cathepsin B 0.0063 0.1187 0.1594
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0063 0.1187 0.3843
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.002 0.0175 0.0162
Brugia malayi chromobox protein homolog 3 0.0041 0.0669 0.1329
Brugia malayi Heterochromatin protein 1 0.0073 0.1441 0.2894
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0092 0.1897 0.334
Entamoeba histolytica Ran family GTPase 0.0022 0.0219 0.0257
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0274 0.0478
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0566 0.121
Brugia malayi hypothetical protein 0.0017 0.0095 0.0165
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0592 0.0589
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.005 0.0873 0.0861
Schistosoma mansoni chromobox protein 0.0073 0.1441 0.143
Entamoeba histolytica cysteine proteinase, putative 0.0063 0.1199 0.5946
Schistosoma mansoni lamin 0.0028 0.0364 0.0352
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0136 0.0234
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0419 0.0417
Loa Loa (eye worm) matrixin family protein 0.0082 0.1657 0.2224
Loa Loa (eye worm) hypothetical protein 0.002 0.0175 0.0235
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.074 0.0728
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0013 0.0018
Entamoeba histolytica cysteine protease, putative 0.005 0.0873 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.0092 0.1897 0.1887
Brugia malayi Cathepsin L-like precursor 0.0092 0.1897 0.3818
Schistosoma mansoni hypothetical protein 0.043 1 1
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0566 0.1635
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.032 0.0841
Loa Loa (eye worm) hypothetical protein 0.0031 0.0419 0.0563
Echinococcus multilocularis dnaJ subfamily B 0.043 1 1
Brugia malayi Papain family cysteine protease containing protein 0.005 0.0873 0.1743
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.002 0.0175 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0175 0.0303
Toxoplasma gondii cathepsin B 0.0063 0.1187 0.5875
Brugia malayi Cathepsin L-like precursor 0.0063 0.1199 0.2403
Schistosoma mansoni cpg binding protein 0.0032 0.045 0.0437
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0157 0.3447 0.3438
Brugia malayi Hemopexin family protein 0.0053 0.0945 0.1888
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0136 0.0234
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0419 0.1319
Schistosoma mansoni cathepsin F (C01 family) 0.0092 0.1897 0.1887
Brugia malayi cathepsin L precursor 0.002 0.0175 0.0328
Loa Loa (eye worm) hypothetical protein 0.0093 0.1907 0.256
Schistosoma mansoni lamin 0.0028 0.0364 0.0352
Echinococcus granulosus cathepsin L cysteine protease 0.005 0.0873 0.0871
Toxoplasma gondii hypothetical protein 0.0077 0.1537 0.7906
Echinococcus multilocularis chromobox protein 1 0.0073 0.1441 0.1439
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0969 0.7849
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0157 0.3447 0.3438
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.002 0.0175 0.0162
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0003 0.0004
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0219 0.0628
Brugia malayi Cathepsin L-like precursor 0.0092 0.1897 0.3818

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.00074 M Inhibitory activity of the compound against human amniotic renin (competitive inhibition) ChEMBL. 6352942
Ki (binding) = 0.001 M Inhibitory activity of the compound against hog kidney renin (noncompetitive inhibition) ChEMBL. 6352942

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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