Detailed information for compound 47323

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 288.272 | Formula: C8H16O9S
  • H donors: 5 H acceptors: 7 LogP: -3.35 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(O)(COS(=O)(=O)C)C(C(C1O)O)O
  • InChi: 1S/C8H16O9S/c1-18(14,15)16-3-8(13)7(12)6(11)5(10)4(2-9)17-8/h4-7,9-13H,2-3H2,1H3
  • InChiKey: RODJTJLRGLQAPX-UHFFFAOYSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni neuropeptide receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0006 0.0018 0.0018
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0202 0.0514
Echinococcus granulosus tyrosine kinase 0.0006 0.0008 0.0008
Brugia malayi putative neuropeptide receptor NPR1 0.0006 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0009 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Schistosoma mansoni tyrosine kinase 0.0009 0.0061 0.0061
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0152 0.2211 0.2211
Onchocerca volvulus 0.0065 0.0909 0.2678
Trypanosoma brucei RNA helicase, putative 0.0242 0.3575 1
Schistosoma mansoni biogenic amine receptor 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.007 0.0114
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0114
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0202 0.0202
Echinococcus multilocularis G-protein coupled receptor, putative 0.0006 0.0018 0.0018
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0809 0.0809
Schistosoma mansoni amine GPCR 0.0006 0.0018 0.0018
Echinococcus multilocularis neuropeptide Y receptor 0.0006 0.0018 0.0018
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0202 0.0202
Echinococcus granulosus tyrosine protein kinase shark 0.0006 0.0008 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0202 0.0468
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0006 0.0008 0.0008
Echinococcus multilocularis 0.0008 0.0046 0.0046
Schistosoma mansoni neuropeptide f receptor 76f 0.0006 0.0018 0.0018
Onchocerca volvulus 0.0006 0.0018 0.0038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0006 0.0018 0.0018
Loa Loa (eye worm) G-protein coupled receptor 0.0006 0.0018 0.0029
Brugia malayi neuropeptide F receptor 0.0006 0.0018 0.0045
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0909 0.0909
Schistosoma mansoni biogenic amine receptor 0.0006 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0065 0.0909 0.0909
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.007 0.0177
Brugia malayi Serotonin receptor 0.0006 0.0018 0.0045
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0006 0.0018 0.0029
Onchocerca volvulus 0.0006 0.0018 0.0038
Loa Loa (eye worm) proprotein convertase 2 0.0008 0.0046 0.0075
Loa Loa (eye worm) hypothetical protein 0.0058 0.0794 0.1303
Echinococcus multilocularis rhodopsin orphan GPCR 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0065 0.0909 0.1491
Echinococcus multilocularis somatostatin receptor 0.0006 0.0018 0.0018
Echinococcus granulosus neuropeptides capa receptor 0.0006 0.0018 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0065 0.0909 0.1491
Brugia malayi Guanylate kinase family protein 0.0006 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.041 0.6097 1
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0114
Onchocerca volvulus 0.0006 0.0018 0.0038
Schistosoma mansoni myosin xvIII 0.0006 0.0018 0.0018
Echinococcus multilocularis expressed protein 0.0362 0.5373 0.5373
Onchocerca volvulus 0.0029 0.0358 0.1045
Echinococcus granulosus rhodopsin orphan GPCR 0.0006 0.0018 0.0018
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0008 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Onchocerca volvulus 0.0006 0.0018 0.0038
Schistosoma mansoni adapter molecule crk 0.0007 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Echinococcus granulosus rhodopsin orphan GPCR 0.0006 0.0018 0.0018
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0202 0.0202
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0152 0.2211 0.2211
Schistosoma mansoni neuropeptide receptor 0.0006 0.0018 0.0018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.2961 0.4858
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.0794 0.0794
Brugia malayi SRC-1 0.0009 0.0061 0.0156
Brugia malayi Protein kinase domain containing protein 0.0006 0.0008 0.002
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0065 0.0909 0.0909
Schistosoma mansoni polycystin 1-related 0.0058 0.0794 0.0794
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0009 0.0061 0.0061
Echinococcus granulosus biogenic amine 5HT receptor 0.0006 0.0018 0.0018
Brugia malayi RE15519p 0.0006 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0065 0.0909 0.1491
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0006 0.0018 0.0018
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0006 0.0018 0.0018
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.3787 0.6211
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Brugia malayi PXA domain containing protein 0.0019 0.0202 0.0514
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0006 0.0018 0.0018
Schistosoma mansoni neuropeptide F-like receptor 0.0006 0.0018 0.0018
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.007 0.007
Onchocerca volvulus 0.0006 0.0008 0.0008
Onchocerca volvulus 0.0065 0.0909 0.2678
Echinococcus granulosus expressed protein 0.0362 0.5373 0.5373
Schistosoma mansoni opsin-like receptor 0.0006 0.0018 0.0018
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0008 0.0013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.007 0.007
Echinococcus multilocularis fmrfamide receptor 0.0006 0.0018 0.0018
Brugia malayi G-protein coupled receptor 0.0006 0.0018 0.0045
Schistosoma mansoni hypothetical protein 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0006 0.0018 0.0045
Echinococcus multilocularis neuropeptide s receptor 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0006 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0202 0.0331
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0202 0.0202
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0006 0.0018 0.0029
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0008 0.0046 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0065 0.0909 0.0909
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0909 0.0909
Brugia malayi PXA domain containing protein 0.0019 0.0202 0.0514
Echinococcus granulosus neuropeptides capa receptor 0.0006 0.0018 0.0018
Onchocerca volvulus 0.0006 0.0008 0.0008
Schistosoma mansoni growth hormone secretagogue receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0202 0.0202
Onchocerca volvulus 0.0008 0.0046 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0358 0.0358
Schistosoma mansoni thyroid hormone receptor 0.001 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0202 0.0331
Onchocerca volvulus 0.0006 0.0018 0.0038
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0202 0.0202
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0809 1
Echinococcus granulosus glycoprotein Antigen 5 0.0065 0.0909 0.0909
Brugia malayi Trypsin-like protease protein 5 0.0065 0.0909 0.2313
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0202 0.0202
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0006 0.0018 0.0018
Brugia malayi neuroendocrine convertase 1 precursor 0.0008 0.0046 0.0117
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0358 0.0358
Schistosoma mansoni site-1 peptidase (S08 family) 0.0008 0.0046 0.0046
Onchocerca volvulus 0.0065 0.0909 0.2678
Echinococcus multilocularis transmembrane protease serine 3 0.0065 0.0909 0.0909
Brugia malayi Pre-SET motif family protein 0.0202 0.2961 0.7534
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0266 0.3931 0.3931
Schistosoma mansoni growth factor receptor-bound protein 0.0007 0.0031 0.0031
Echinococcus granulosus tyrosine protein kinase Src64B 0.0009 0.0061 0.0061
Brugia malayi Trypsin family protein 0.0065 0.0909 0.2313
Echinococcus granulosus neuropeptide s receptor 0.0006 0.0018 0.0018
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0202 0.0202
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0065 0.0909 0.0909
Loa Loa (eye worm) TYRA-2 protein 0.0006 0.0018 0.0029
Echinococcus granulosus Polycystic kidney disease protein 0.0058 0.0794 0.0794
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0358 0.0358
Brugia malayi Serotonin receptor 0.0006 0.0018 0.0045
Schistosoma mansoni furin-1 (S08 family) 0.0008 0.0046 0.0046
Brugia malayi hypothetical protein 0.0058 0.0794 0.2021
Schistosoma mansoni site-1 peptidase (S08 family) 0.0008 0.0046 0.0046
Onchocerca volvulus 0.001 0.007 0.0191
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Echinococcus granulosus tyrosine protein kinase Fyn 0.0009 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0019 0.0202 0.0331
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0202 0.0202
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0006 0.0018 0.0018
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0202 0.0202
Brugia malayi nuclear receptor NHR-88 0.001 0.007 0.0177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.007 0.0114
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0909 0.0909
Echinococcus multilocularis Furin 1 0.0008 0.0046 0.0046
Brugia malayi hypothetical protein 0.0019 0.0202 0.0514
Echinococcus multilocularis Mastin 0.0065 0.0909 0.0909
Loa Loa (eye worm) hypothetical protein 0.0065 0.0909 0.1491
Loa Loa (eye worm) hypothetical protein 0.0019 0.0202 0.0331
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Echinococcus multilocularis Polycystic kidney disease protein 0.0058 0.0794 0.0794
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis g protein coupled receptor 0.0006 0.0018 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.007 0.0114
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0202 0.0202
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0031 0.0078
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0202 0.0514
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0006 0.0018 0.0018
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.0794 0.0794
Onchocerca volvulus 0.0065 0.0909 0.2678
Echinococcus multilocularis neuropeptide Y receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0009 0.0061 0.0061
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0114
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0065 0.0909 0.0909
Schistosoma mansoni tyrosine kinase 0.0009 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0114
Schistosoma mansoni alpha-1 adrenergic receptor 0.0006 0.0018 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0358 0.0358
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0202 0.0514
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Echinococcus multilocularis enteropeptidase 0.0065 0.0909 0.0909
Schistosoma mansoni hypothetical protein 0.0242 0.3575 0.3575
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0346 0.514 0.514
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0809 0.0809
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0809 0.8837
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Onchocerca volvulus 0.0006 0.0008 0.0008
Mycobacterium leprae Possible secreted protease 0.0008 0.0046 0.5
Echinococcus granulosus g protein coupled receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.007 0.007
Brugia malayi SH2 domain containing protein 0.0006 0.0008 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0202 0.0202
Echinococcus multilocularis neuropeptide receptor A26 0.0006 0.0018 0.0018
Schistosoma mansoni protein kinase 0.0152 0.2211 0.2211
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Schistosoma mansoni tyrosine kinase 0.0009 0.0061 0.0061
Loa Loa (eye worm) doublecortin family protein 0.0058 0.0794 0.1303
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.007 0.0177
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0008 0.0013
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0006 0.0018 0.0018
Echinococcus granulosus Mastin 0.0065 0.0909 0.0909
Brugia malayi G protein-coupled receptor F59B2.13 0.0006 0.0018 0.0045
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0202 0.0514
Echinococcus multilocularis neuropeptides capa receptor 0.0006 0.0018 0.0018
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis glycoprotein Antigen 5 0.0065 0.0909 0.0909
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Schistosoma mansoni microtubule-associated protein tau 0.0669 1 1
Echinococcus multilocularis allatostatin A receptor 0.0006 0.0018 0.0018
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0006 0.0018 0.0018
Brugia malayi endoprotease bli-4 precursor 0.0008 0.0046 0.0117
Echinococcus granulosus orexin receptor type 2 0.0006 0.0018 0.0018
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.01 0.1423 0.1423
Brugia malayi AKH receptor 0.0006 0.0018 0.0045
Echinococcus granulosus G protein coupled receptor 139 0.0006 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.007 0.0177
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0114
Schistosoma mansoni lipoxygenase 0.0346 0.514 0.514
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0202 0.0468
Echinococcus multilocularis rhodopsin orphan GPCR 0.0006 0.0018 0.0018
Echinococcus multilocularis FTZ F1 alpha 0.001 0.007 0.007
Echinococcus granulosus c src tyrosine kinase 0.0009 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.0006 0.0018 0.0018
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.007 0.007
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0342 0.0342
Onchocerca volvulus 0.0006 0.0008 0.0008
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0007 0.0031 0.005
Echinococcus multilocularis G protein coupled receptor 139 0.0006 0.0018 0.0018
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0006 0.0018 0.0018
Loa Loa (eye worm) SRC-1 0.0009 0.0061 0.0101
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0009 0.0061 0.0061
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0006 0.0008 0.0008
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0006 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.007 0.007
Echinococcus granulosus peptide allatostatin:somatostatin 0.0006 0.0018 0.0018
Echinococcus granulosus tyrosine protein kinase Fyn 0.0009 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Schistosoma mansoni neuropeptide F-like receptor 0.0006 0.0018 0.0018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.007 0.0114
Echinococcus granulosus tm gpcr rhodopsin 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Echinococcus granulosus alpha 1A adrenergic receptor 0.0006 0.0018 0.0018
Echinococcus granulosus hypothetical protein 0.0006 0.0018 0.0018
Schistosoma mansoni opsin-like receptor 0.0006 0.0018 0.0018
Brugia malayi Tachykinin-like peptides receptor 99D 0.0006 0.0018 0.0045
Loa Loa (eye worm) TK protein kinase 0.0006 0.0008 0.0013
Loa Loa (eye worm) neuropeptide F receptor 0.0006 0.0018 0.0029
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0006 0.0018 0.0018
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0065 0.0909 0.0909
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Echinococcus granulosus g protein coupled receptor 0.0006 0.0018 0.0018
Brugia malayi putative neuropeptide receptor 0.0006 0.0018 0.0045
Schistosoma mansoni adenoreceptor 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0114
Brugia malayi Protein kinase domain containing protein 0.0006 0.0008 0.002
Echinococcus multilocularis neuropeptide FF receptor 2 0.0006 0.0018 0.0018
Loa Loa (eye worm) endoprotease bli-4 0.0008 0.0046 0.0075
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0065 0.0909 0.0909
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0008 0.0013
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0909 0.0909
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0006 0.0018 0.0018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0809 0.8837
Plasmodium falciparum LCCL domain-containing protein 0.0058 0.0794 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0809 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0358 0.417
Brugia malayi Tyrosine-protein kinase abl-1 0.0009 0.0061 0.0156
Echinococcus granulosus neuropeptide FF receptor 2 0.0006 0.0018 0.0018
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0006 0.0018 0.0018
Brugia malayi follicle stimulating hormone receptor 0.0256 0.3787 0.9634
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.007 0.007
Schistosoma mansoni amine GPCR 0.0006 0.0018 0.0018
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0202 0.0331
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.007 0.007
Echinococcus multilocularis tyrosine protein kinase Srms 0.0006 0.0008 0.0008
Echinococcus multilocularis tyrosine protein kinase shark 0.0006 0.0008 0.0008
Brugia malayi protein-tyrosine kinase 0.0006 0.0008 0.002
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0065 0.0909 0.2313
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0013
Echinococcus multilocularis microtubule associated protein 2 0.0669 1 1
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0065 0.0909 0.0909
Brugia malayi hypothetical protein 0.0006 0.0018 0.0045
Schistosoma mansoni neuropeptide receptor 0.0006 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.007 0.0177
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0009 0.0061 0.0061
Echinococcus granulosus membrane bound transcription factor site 1 0.0008 0.0046 0.0046
Brugia malayi GnHR receptor homolog 0.0006 0.0018 0.0045
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0009 0.0061 0.0061
Echinococcus multilocularis neuropeptides capa receptor 0.0006 0.0018 0.0018
Echinococcus granulosus NCK adaptor protein 0.0007 0.0031 0.0031
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0358 0.0358
Echinococcus granulosus RUN 0.0058 0.0794 0.0794
Schistosoma mansoni serine/threonine protein kinase 0.0006 0.0007 0.0007
Schistosoma mansoni lipoxygenase 0.0242 0.357 0.357
Onchocerca volvulus 0.0006 0.0018 0.0038
Echinococcus granulosus rhodopsin orphan GPCR 0.0006 0.0018 0.0018
Brugia malayi steroid hormone receptor 0.001 0.007 0.0177
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0065 0.0909 0.0909
Schistosoma mansoni loxhd1 0.0058 0.0794 0.0794
Onchocerca volvulus 0.0229 0.3381 1
Echinococcus multilocularis neuropeptide receptor 0.0006 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.007 0.0177
Onchocerca volvulus 0.0006 0.0018 0.0038
Echinococcus granulosus neuropeptide receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0202 0.0202
Onchocerca volvulus 0.0006 0.0008 0.0008
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0065 0.0909 0.0909
Schistosoma mansoni protein kinase 0.0152 0.2211 0.2211
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.007 0.0177
Echinococcus granulosus tyrosine protein kinase Lyn 0.0009 0.0061 0.0061
Brugia malayi Dopamine receptor protein 2 0.0006 0.0018 0.0045
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0202 0.0514
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.007 0.0177
Onchocerca volvulus 0.0065 0.0909 0.2678
Echinococcus granulosus tm gpcr rhodopsin 0.0006 0.0018 0.0018
Onchocerca volvulus Neuropeptide F receptor homolog 0.0006 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0202 0.0202
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.007 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0008 0.0013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.007 0.0177
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0114
Brugia malayi Trypsin family protein 0.0065 0.0909 0.2313
Echinococcus multilocularis rhodopsin orphan GPCR 0.0006 0.0018 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0006 0.0018 0.0018
Schistosoma mansoni opsin-like receptor 0.0006 0.0018 0.0018
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0065 0.0909 0.0909
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.007 0.007
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0202 0.0202
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0006 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0019 0.0202 1
Echinococcus granulosus furin 0.0008 0.0046 0.0046
Onchocerca volvulus 0.0006 0.0008 0.0008
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0909 0.0909
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Echinococcus granulosus tyrosine protein kinase Fyn 0.0009 0.0061 0.0061
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0202 0.0202
Brugia malayi Protein kinase domain containing protein 0.0006 0.0008 0.002
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0006 0.0018 0.0029
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0008 0.0013
Onchocerca volvulus 0.0006 0.0018 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0006 0.0018 0.0018
Echinococcus multilocularis tyrosine protein kinase Abl 0.0009 0.0061 0.0061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0006 0.0018 0.0018
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.007 0.007
Loa Loa (eye worm) TK/ABL protein kinase 0.0006 0.0008 0.0013
Loa Loa (eye worm) guanylate kinase 0.0006 0.0005 0.0008
Brugia malayi Subtilase family protein 0.0266 0.3931 1
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0231 0.0231
Echinococcus multilocularis rhodopsin orphan GPCR 0.0006 0.0018 0.0018
Brugia malayi Sex muscle abnormal protein 5 0.0007 0.0031 0.0078
Onchocerca volvulus 0.0006 0.0018 0.0038
Echinococcus granulosus rhodopsin orphan GPCR 0.0006 0.0018 0.0018
Echinococcus granulosus rhodopsin orphan GPCR 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Echinococcus granulosus tyrosine protein kinase ABL1 0.0006 0.0008 0.0008
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0008 0.0046 0.0117
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0007 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0065 0.0909 0.1491
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0008 0.0046 0.0046
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0006 0.0018 0.0018
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0008 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.007 0.0177
Schistosoma mansoni nck2/grb4 0.0007 0.0031 0.0031
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0202 0.0202
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0202 0.0331
Entamoeba histolytica hypothetical protein 0.0019 0.0202 1
Schistosoma mansoni biogenic amine receptor 0.0006 0.0018 0.0018
Echinococcus granulosus g-protein coupled receptor 0.0006 0.0018 0.0018
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.007 0.0191
Brugia malayi Doublecortin family protein 0.0058 0.0794 0.2021
Schistosoma mansoni neuropeptide receptor 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.007 0.0114
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0006 0.0018 0.0018
Brugia malayi G protein-coupled receptor 0.0006 0.0018 0.0045
Trichomonas vaginalis set domain proteins, putative 0.0229 0.3381 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.007 0.0177
Echinococcus granulosus biogenic amine 5HT receptor 0.0006 0.0018 0.0018
Echinococcus granulosus Furin 1 0.0008 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.007 0.0177
Echinococcus multilocularis rhodopsin orphan GPCR 0.0006 0.0018 0.0018
Loa Loa (eye worm) steroid hormone receptor 0.001 0.007 0.0114
Brugia malayi proprotein convertase 2 0.0008 0.0046 0.0117
Loa Loa (eye worm) hypothetical protein 0.0029 0.0358 0.0587
Brugia malayi ecdysteroid receptor 0.001 0.007 0.0177
Echinococcus multilocularis g protein coupled receptor 0.0006 0.0018 0.0018
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0202 0.0331
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0007 0.0031 0.005
Schistosoma mansoni amine GPCR 0.0006 0.0018 0.0018
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0006 0.0018 0.0018
Schistosoma mansoni growth factor receptor-bound protein 0.0007 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0202 0.0468
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0202 0.0331
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0202 0.0202
Brugia malayi Protein kinase domain containing protein 0.0006 0.0008 0.002
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0909 0.0909
Schistosoma mansoni histamine h1 receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.01 0.1423 0.1423
Brugia malayi hypothetical protein 0.0006 0.0018 0.0045
Schistosoma mansoni tyrosine kinase 0.0009 0.0061 0.0061
Echinococcus granulosus neuropeptide Y receptor 0.0006 0.0018 0.0018
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0202 0.0202
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0202 0.0202
Loa Loa (eye worm) G-protein coupled receptor 0.0006 0.0018 0.0029
Brugia malayi Peripheral plasma membrane protein CASK 0.0006 0.0005 0.0013
Echinococcus multilocularis growth factor receptor bound protein 2 0.0007 0.0031 0.0031
Onchocerca volvulus 0.0006 0.0018 0.0038
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0358 0.4091
Echinococcus multilocularis neuropeptide receptor 0.0006 0.0018 0.0018
Schistosoma mansoni rab6-interacting 0.0058 0.0794 0.0794
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0202 0.0202
Onchocerca volvulus 0.0058 0.0794 0.2338
Brugia malayi ORL1-like opioid receptor 0.0006 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Brugia malayi hypothetical protein 0.0006 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0008 0.0046 0.5
Brugia malayi larval opioid receptor 0.0006 0.0018 0.0045
Brugia malayi neuropeptide F receptor 0.0006 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Echinococcus multilocularis serotonin receptor 0.0006 0.0018 0.0018
Echinococcus granulosus transmembrane protease serine 3 0.0065 0.0909 0.0909
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis neuroendocrine convertase 2 0.0008 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0006 0.0018 0.0018
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.007 0.007
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0009 0.0061 0.0061
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0009 0.0061 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.007 0.0114
Echinococcus multilocularis orexin receptor type 2 0.0006 0.0018 0.0018
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0008 0.0046 0.0046
Brugia malayi Trypsin family protein 0.0065 0.0909 0.2313
Echinococcus granulosus fmrfamide receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis fmrfamide receptor 0.0006 0.0018 0.0018
Echinococcus granulosus FTZ F1 alpha 0.001 0.007 0.007
Brugia malayi hypothetical protein 0.0058 0.0794 0.2021
Brugia malayi hypothetical protein 0.0065 0.0909 0.2313
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis RUN 0.0058 0.0794 0.0794
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0358 0.0358
Loa Loa (eye worm) trypsin family protein 0.0065 0.0909 0.1491
Echinococcus granulosus enteropeptidase 0.0065 0.0909 0.0909
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0006 0.0018 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0358 0.0358
Loa Loa (eye worm) neuropeptide F receptor 0.0006 0.0018 0.0029
Echinococcus granulosus 7tm_1 domain containing protein 0.0006 0.0018 0.0018
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0009 0.0061 0.0061
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0065 0.0909 0.0909
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0006 0.0008 0.0008
Echinococcus granulosus sex peptide receptor 0.0006 0.0018 0.0018
Schistosoma mansoni amine GPCR 0.0006 0.0018 0.0018
Echinococcus granulosus growth factor receptor bound protein 2 0.0007 0.0031 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.007 0.0177
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0006 0.0018 0.0038
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0202 0.0202
Onchocerca volvulus 0.0006 0.0018 0.0038
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.007 0.0177
Onchocerca volvulus Bile acid receptor homolog 0.001 0.007 0.0191
Onchocerca volvulus 0.0006 0.0018 0.0038
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0202 0.0202
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0008 0.0046 0.0117
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0006 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.007 0.0177
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0009 0.0061 0.0061
Echinococcus granulosus tachykinin peptides receptor 99D 0.0006 0.0018 0.0018
Echinococcus multilocularis serotonin receptor 0.0006 0.0018 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0006 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0202 0.0468
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0006 0.0018 0.0045
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0006 0.0018 0.0018
Echinococcus multilocularis g-protein coupled receptor 0.0006 0.0018 0.0018
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0202 0.0331
Loa Loa (eye worm) POT family protein 0.0216 0.3182 0.5219
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0809 0.8837
Brugia malayi nuclear hormone receptor 0.001 0.007 0.0177
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.007 0.0114
Echinococcus multilocularis NCK adaptor protein 0.0007 0.0031 0.0031
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.007 0.007
Brugia malayi Dopamine receptor 0.0006 0.0018 0.0045
Brugia malayi Steroid receptor seven-up type 2 0.001 0.007 0.0177
Entamoeba histolytica hypothetical protein 0.0019 0.0202 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0006 0.0018 0.0018
Brugia malayi Trypsin family protein 0.0065 0.0909 0.2313
Brugia malayi hypothetical protein 0.0006 0.0008 0.002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.007 0.007
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0006 0.0018 0.0045
Brugia malayi hypothetical protein 0.0006 0.0018 0.0045
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0006 0.0018 0.0018
Brugia malayi hypothetical protein 0.0006 0.0018 0.0045
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0202 0.0202
Echinococcus granulosus rhodopsin orphan GPCR 0.0006 0.0018 0.0018
Echinococcus granulosus allatostatin A receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis dro:myosuppressin receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis g protein coupled receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Brugia malayi POT family protein 0.0216 0.3182 0.8095
Schistosoma mansoni hypothetical protein 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0075
Brugia malayi Dopamine receptor protein 1 0.0006 0.0018 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0202 0.0468
Brugia malayi hypothetical protein 0.0019 0.0202 0.0514
Echinococcus granulosus neuropeptide Y receptor 0.0006 0.0018 0.0018
Schistosoma mansoni biogenic amine (5HT) receptor 0.0006 0.0018 0.0018
Brugia malayi hypothetical protein 0.0006 0.0018 0.0045
Echinococcus granulosus g protein coupled receptor 0.0006 0.0018 0.0018
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.007 0.007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0006 0.0018 0.0018
Onchocerca volvulus 0.0006 0.0018 0.0038
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.0794 0.0794
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0202 0.0202
Schistosoma mansoni coup transcription factor 0.001 0.007 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Brugia malayi hypothetical protein 0.0006 0.0018 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0202 0.0468
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.007 0.0177
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.007 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0008 0.0013
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.007 0.007
Leishmania major hypothetical protein, conserved 0.0025 0.0296 0.3282
Schistosoma mansoni hypothetical protein 0.0058 0.0794 0.0794
Echinococcus granulosus serotonin receptor 0.0006 0.0018 0.0018
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.007 0.007
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Brugia malayi Pre-SET motif family protein 0.0029 0.0358 0.0911
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0202 0.0514
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0006 0.0018 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0296 1
Schistosoma mansoni tyrosine kinase 0.0006 0.0008 0.0008
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0202 0.0202
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.007 0.0114
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0909 0.0909
Loa Loa (eye worm) melatonin receptor type 1A 0.0006 0.0018 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0202 0.0468
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0009 0.0061 0.0061
Schistosoma mansoni nuclear hormone receptor 0.001 0.007 0.007
Onchocerca volvulus 0.0006 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0007 0.0031 0.005
Brugia malayi Protein kinase domain containing protein 0.0006 0.0008 0.002
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0809 0.0809
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0006 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0065 0.0909 0.1491
Onchocerca volvulus 0.0058 0.0794 0.2338
Echinococcus multilocularis c src tyrosine kinase 0.0009 0.0061 0.0061
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0202 0.0202
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0008 0.0013
Echinococcus multilocularis membrane bound transcription factor site 1 0.0008 0.0046 0.0046
Brugia malayi Melatonin receptor type 1A 0.0006 0.0018 0.0045
Echinococcus granulosus 7TM GPCR rhodopsin 0.0006 0.0018 0.0018
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0909 0.0909
Loa Loa (eye worm) hypothetical protein 0.041 0.6097 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.007 0.007
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0009 0.0061 0.0061
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0006 0.0018 0.0029
Loa Loa (eye worm) hypothetical protein 0.0065 0.0909 0.1491
Schistosoma mansoni hypothetical protein 0.0065 0.0909 0.0909
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0009 0.0061 0.0061
Mycobacterium ulcerans hypothetical protein 0.0065 0.0909 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.007 0.007
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0008 0.0046 0.0046
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.007 0.0191
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0008 0.0046 0.0046
Echinococcus granulosus neuropeptide receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.007 0.007
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0809 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0006 0.0018 0.0018
Echinococcus granulosus tm gpcr rhodopsin 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Schistosoma mansoni rab6-interacting 0.0058 0.0794 0.0794
Brugia malayi G-protein coupled receptor 0.0006 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Brugia malayi hypothetical protein 0.0006 0.0018 0.0045
Echinococcus granulosus neuropeptide receptor A26 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0006 0.0018 0.0018
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0031 0.0078
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0006 0.0018 0.0045
Brugia malayi sulfakinin receptor protein 0.0006 0.0018 0.0045
Onchocerca volvulus 0.0006 0.0018 0.0038
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0006 0.0018 0.0018
Brugia malayi hypothetical protein 0.0006 0.0018 0.0045
Echinococcus multilocularis sex peptide receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.007 0.007
Plasmodium vivax multidomain scavenger receptor, putative 0.0058 0.0794 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0909 0.0909
Onchocerca volvulus 0.0006 0.0018 0.0038
Echinococcus granulosus neuroendocrine convertase 2 0.0008 0.0046 0.0046
Loa Loa (eye worm) subtilase 0.0266 0.3931 0.6447
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0202 0.0202
Echinococcus granulosus tyrosine protein kinase Srms 0.0006 0.0008 0.0008
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0006 0.0018 0.0018
Brugia malayi SH2 domain containing protein 0.0006 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0006 0.0018 0.0029
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0202 0.0202
Echinococcus granulosus tyrosine protein kinase Src42A 0.0009 0.0061 0.0061
Brugia malayi celfurPC protein 0.0008 0.0046 0.0117
Echinococcus granulosus tyrosine kinase 0.0006 0.0008 0.0008
Echinococcus multilocularis tyrosine kinase 0.0006 0.0008 0.0008
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0346 0.514 0.514
Schistosoma mansoni tyrosine kinase 0.0006 0.0008 0.0008
Echinococcus granulosus tyrosine protein kinase Blk 0.0006 0.0008 0.0008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.007 0.007
Echinococcus granulosus rhodopsin orphan GPCR 0.0006 0.0018 0.0018
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0809 0.0809
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.007 0.007
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0202 0.0202
Loa Loa (eye worm) TK/FER protein kinase 0.0006 0.0008 0.0013
Echinococcus granulosus somatostatin receptor 0.0006 0.0018 0.0018
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0009 0.0061 0.0061
Onchocerca volvulus 0.0065 0.0909 0.2678
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0909 0.0909
Loa Loa (eye worm) hypothetical protein 0.0019 0.0202 0.0331
Echinococcus multilocularis tyrosine protein kinase Blk 0.0006 0.0008 0.0008
Schistosoma mansoni amine GPCR 0.0006 0.0018 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0296 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0006 0.0018 0.0018
Onchocerca volvulus 0.0006 0.0018 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0202 0.0202
Echinococcus granulosus dro:myosuppressin receptor 0.0006 0.0018 0.0018
Schistosoma mansoni biogenic amine (5HT) receptor 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0008 0.0046 0.0075
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.0794 0.0794
Brugia malayi hypothetical protein 0.0006 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0058 0.0794 0.1303
Loa Loa (eye worm) hypothetical protein 0.0019 0.0202 0.0331
Schistosoma mansoni cercarial elastase (S01 family) 0.0065 0.0909 0.0909
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0065 0.0909 0.0909
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0006 0.0018 0.0018

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 3.7 mM Inhibition of rabbit glycogen phosphorylase B enzyme ChEMBL. 9154968
lnKi (binding) = 1.31 Tested for inhibition constant against glycogen phosphorylase b ChEMBL. 8057302
Log Ki (binding) = 2.43 mM Inhibitory activity against rabbit muscle glycogen phosphorylase ChEMBL. 9406599

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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