Detailed information for compound 504530

Basic information

Technical information
  • TDR Targets ID: 504530
  • Name: (E)-3-(4-bromophenyl)-1-(4-tert-butylphenyl)p rop-2-en-1-one
  • MW: 343.258 | Formula: C19H19BrO
  • H donors: 0 H acceptors: 1 LogP: 6.05 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)/C=C/C(=O)c1ccc(cc1)C(C)(C)C
  • InChi: 1S/C19H19BrO/c1-19(2,3)16-9-7-15(8-10-16)18(21)13-6-14-4-11-17(20)12-5-14/h4-13H,1-3H3/b13-6+
  • InChiKey: FTUXPHRBWFOZFG-AWNIVKPZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-(4-bromophenyl)-1-(4-tert-butylphenyl)-2-propen-1-one
  • ZINC06410680

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Onchocerca volvulus 0.0066 0.0075 0.0136
Onchocerca volvulus 0.0043 0.0019 0.0035
Echinococcus granulosus 7tm_1 domain containing protein 0.0089 0.0133 0.0133
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0468 0.109 0.1522
Echinococcus multilocularis tyrosine protein kinase Blk 0.0124 0.0221 0.0221
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0089 0.0133 0.0133
Echinococcus granulosus fmrfamide receptor 0.0089 0.0133 0.0133
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0043 0.0019 0.0035
Brugia malayi SH2 domain containing protein 0.0066 0.0075 0.0104
Echinococcus granulosus tyrosine protein kinase otk 0.004 0.0009 0.0009
Echinococcus granulosus neuropeptide Y receptor 0.0089 0.0133 0.0133
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0129 0.0235 0.0235
Schistosoma mansoni opsin-like receptor 0.0089 0.0133 0.0243
Schistosoma mansoni vav2 0.0045 0.0023 0.0042
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0089 0.0133 0.0133
Echinococcus granulosus tyrosine protein kinase Srms 0.0066 0.0075 0.0075
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.0133 0.0133
Brugia malayi hypothetical protein 0.0089 0.0133 0.0186
Echinococcus granulosus growth factor receptor bound protein 2 0.0053 0.0044 0.0044
Echinococcus granulosus orexin receptor type 2 0.0089 0.0133 0.0133
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0066 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.0013
Echinococcus granulosus tyrosine protein kinase HCK 0.0088 0.013 0.013
Schistosoma mansoni opsin-like receptor 0.0089 0.0133 0.0243
Schistosoma mansoni septate junction protein 0.004 0.0009 0.0017
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0089 0.0133 0.0133
Brugia malayi hypothetical protein 0.0089 0.0133 0.0186
Plasmodium falciparum amino acid transporter, putative 0.0374 0.0853 0.0858
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0374 0.0853 0.1192
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus granulosus Immunoglobulin 0.0109 0.0184 0.0184
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0051 0.0038 0.0038
Brugia malayi Dopamine receptor protein 2 0.0089 0.0133 0.0186
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Brugia malayi Fibronectin type III domain containing protein 0.012 0.0212 0.0296
Brugia malayi Protein kinase domain containing protein 0.0172 0.0342 0.0478
Echinococcus multilocularis fmrfamide receptor 0.0089 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus granulosus raf serine:threonine protein kinase 0.0244 0.0525 0.0525
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus multilocularis neuroglian 0.0051 0.0038 0.0038
Schistosoma mansoni sodium/chloride dependent transporter 0.2204 0.5471 1
Echinococcus granulosus roundabout 2 0.0051 0.0038 0.0038
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0141 0.0265 0.0265
Entamoeba histolytica protein kinase, putative 0.0042 0.0015 0.1179
Loa Loa (eye worm) hypothetical protein 0.0237 0.0508 0.0709
Loa Loa (eye worm) hypothetical protein 0.0186 0.0378 0.0529
Brugia malayi Protein kinase domain containing protein 0.0066 0.0075 0.0104
Schistosoma mansoni neuropeptide receptor 0.0089 0.0133 0.0243
Loa Loa (eye worm) SRC-1 0.0141 0.0265 0.0371
Schistosoma mansoni hypothetical protein 0.0089 0.0133 0.0243
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0374 0.0853 0.0858
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Schistosoma mansoni amine GPCR 0.0089 0.0133 0.0243
Loa Loa (eye worm) hypothetical protein 0.0374 0.0853 0.1192
Schistosoma mansoni neuroglian 0.0051 0.0038 0.0069
Onchocerca volvulus 0.0089 0.0133 0.0243
Schistosoma mansoni neuropeptide F-like receptor 0.0089 0.0133 0.0243
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0089 0.0133 0.0243
Echinococcus granulosus neuropeptide Y receptor 0.0089 0.0133 0.0133
Echinococcus granulosus c src tyrosine kinase 0.0083 0.0119 0.0119
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0374 0.0853 0.156
Echinococcus multilocularis slit 2 protein 0.0057 0.0053 0.0053
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0048 0.003 0.0042
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0089 0.0133 0.0243
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0051 0.0038 0.0038
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0089 0.0133 0.0133
Schistosoma mansoni protein kinase 0.0042 0.0015 0.0028
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0089 0.0133 0.0186
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0075 0.0104
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0042 0.0015 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.0133 0.0133
Schistosoma mansoni nephrin 0.0051 0.0038 0.0069
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.004 0.0009 0.0013
Onchocerca volvulus 0.0089 0.0133 0.0243
Brugia malayi Protein kinase domain containing protein 0.0066 0.0075 0.0104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0133 0.0243
Brugia malayi hypothetical protein 0.0089 0.0133 0.0186
Schistosoma mansoni ephrin receptor 0.0041 0.0012 0.0022
Entamoeba histolytica tyrosin kinase, putative 0.0037 0.0002 0.0138
Onchocerca volvulus 0.0089 0.0133 0.0243
Brugia malayi Tyrosine-protein kinase abl-1 0.0127 0.0229 0.032
Entamoeba histolytica protein kinase, putative 0.0088 0.013 1
Onchocerca volvulus 0.0089 0.0133 0.0243
Schistosoma mansoni adapter molecule crk 0.0053 0.0044 0.0081
Loa Loa (eye worm) TK/ALK protein kinase 0.0264 0.0574 0.0802
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Onchocerca volvulus 0.2204 0.5471 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0141 0.0265 0.0265
Loa Loa (eye worm) neuropeptide F receptor 0.0089 0.0133 0.0186
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0075 0.0104
Loa Loa (eye worm) hypothetical protein 0.0109 0.0184 0.0257
Echinococcus multilocularis neuropeptide receptor 0.0089 0.0133 0.0133
Echinococcus multilocularis tyrosine protein kinase 0.0267 0.0583 0.0583
Echinococcus granulosus sex peptide receptor 0.0089 0.0133 0.0133
Loa Loa (eye worm) CAMK protein kinase 0.0043 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.2204 0.5471 0.7642
Echinococcus granulosus tyrosine protein kinase shark 0.0488 0.1141 0.1141
Brugia malayi Sex muscle abnormal protein 5 0.0053 0.0044 0.0062
Brugia malayi follicle stimulating hormone receptor 0.0089 0.0133 0.0186
Brugia malayi Protein kinase domain containing protein 0.0264 0.0575 0.0803
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.0133 0.0133
Brugia malayi Cam kinase protein 1 0.0042 0.0015 0.0021
Schistosoma mansoni neuropeptide receptor 0.0089 0.0133 0.0243
Echinococcus multilocularis lachesin 0.004 0.0009 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0519 0.1218 0.2227
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0133 0.0243
Schistosoma mansoni hypothetical protein 0.0089 0.0133 0.0243
Echinococcus granulosus tyrosine protein kinase Fyn 0.0141 0.0265 0.0265
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0089 0.0133 0.0243
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus granulosus hemicentin 1 0.004 0.0009 0.0009
Schistosoma mansoni biogenic amine (5HT) receptor 0.0089 0.0133 0.0243
Loa Loa (eye worm) raf kinase 0.0215 0.0451 0.0629
Schistosoma mansoni growth hormone secretagogue receptor 0.0089 0.0133 0.0243
Loa Loa (eye worm) hypothetical protein 0.0374 0.0853 0.1192
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0374 0.0853 0.0853
Onchocerca volvulus 0.0066 0.0075 0.0136
Brugia malayi Sodium:neurotransmitter symporter family protein 0.2204 0.5471 0.7642
Loa Loa (eye worm) hypothetical protein 0.0053 0.0044 0.0062
Entamoeba histolytica protein kinase, putative 0.0042 0.0015 0.1179
Loa Loa (eye worm) solute carrier family 6 member 4 0.2204 0.5471 0.7642
Schistosoma mansoni tyrosine kinase 0.0146 0.0278 0.0508
Brugia malayi hypothetical protein 0.0089 0.0133 0.0186
Onchocerca volvulus 0.0089 0.0133 0.0243
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0109 0.0184 0.0184
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0374 0.0853 0.1192
Echinococcus granulosus neuropeptide FF receptor 2 0.0089 0.0133 0.0133
Loa Loa (eye worm) G-protein coupled receptor 0.0089 0.0133 0.0186
Echinococcus granulosus biogenic amine 5HT receptor 0.0089 0.0133 0.0133
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0128 0.0231 0.0231
Brugia malayi Dopamine receptor protein 1 0.0089 0.0133 0.0186
Brugia malayi Protein kinase domain containing protein 0.0066 0.0075 0.0104
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.2873 0.7159 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.3999 1 1
Schistosoma mansoni cell adhesion molecule 0.014 0.0264 0.0482
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0089 0.0133 0.0133
Toxoplasma gondii hypothetical protein 0.0374 0.0853 0.0858
Onchocerca volvulus 0.0309 0.0689 0.1259
Echinococcus multilocularis epidermal growth factor receptor 0.0146 0.0278 0.0278
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0089 0.0133 0.0243
Echinococcus granulosus slit 2 protein 0.0057 0.0053 0.0053
Loa Loa (eye worm) melatonin receptor type 1A 0.0089 0.0133 0.0186
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0374 0.0853 0.1192
Brugia malayi hypothetical protein 0.0089 0.0133 0.0186
Schistosoma mansoni tyrosine kinase 0.0452 0.105 0.1919
Brugia malayi putative neuropeptide receptor 0.0089 0.0133 0.0186
Echinococcus granulosus tyrosine protein kinase Fyn 0.0141 0.0265 0.0265
Echinococcus granulosus roundabout 2 0.0051 0.0038 0.0038
Brugia malayi hypothetical protein 0.0089 0.0133 0.0186
Plasmodium vivax hypothetical protein, conserved 0.0374 0.0853 1
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0075 0.0104
Brugia malayi Tyrosine-protein kinase abl-1 0.0162 0.0317 0.0443
Schistosoma mansoni protein kinase 0.0042 0.0017 0.003
Entamoeba histolytica protein kinase domain containing protein 0.0037 0.0002 0.0138
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0042 0.0015 0.0015
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0089 0.0133 0.0133
Loa Loa (eye worm) TK/INSR protein kinase 0.0288 0.0636 0.0889
Loa Loa (eye worm) hypothetical protein 0.012 0.0212 0.0296
Schistosoma mansoni tyrosine kinase 0.0146 0.0278 0.0508
Echinococcus multilocularis neuropeptide Y receptor 0.0089 0.0133 0.0133
Echinococcus granulosus tyrosine protein kinase Fyn 0.0141 0.0265 0.0265
Schistosoma mansoni tyrosine kinase 0.0069 0.0084 0.0154
Echinococcus multilocularis sodium and chloride dependent glycine 0.0374 0.0853 0.0853
Onchocerca volvulus Tyrosine kinase homolog 0.0358 0.0812 0.1485
Schistosoma mansoni hypothetical protein 0.0089 0.0133 0.0243
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0519 0.1218 0.1702
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0519 0.1218 0.2227
Schistosoma mansoni titin 0.004 0.0009 0.0017
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0089 0.0133 0.0186
Echinococcus granulosus neuropeptide receptor 0.0089 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.012 0.0212 0.0296
Loa Loa (eye worm) norepinephrine transporter 0.2204 0.5471 0.7642
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.004 0.0009 0.0013
Schistosoma mansoni neuropeptide receptor 0.0089 0.0133 0.0243
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0374 0.0853 0.156
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0015 0.0028
Echinococcus granulosus potassium voltage gated channel protein 0.0186 0.0378 0.0378
Echinococcus granulosus allatostatin A receptor 0.0089 0.0133 0.0133
Brugia malayi Immunoglobulin I-set domain containing protein 0.004 0.0009 0.0013
Brugia malayi larval opioid receptor 0.0089 0.0133 0.0186
Echinococcus granulosus tyrosine protein kinase Blk 0.0124 0.0221 0.0221
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0042 0.0015 0.0015
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0089 0.0133 0.0186
Schistosoma mansoni neuropeptide f receptor 76f 0.0089 0.0133 0.0243
Brugia malayi putative neuropeptide receptor NPR1 0.0089 0.0133 0.0186
Brugia malayi Protein kinase domain containing protein 0.2873 0.7159 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0089 0.0133 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0133 0.0243
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0089 0.0133 0.0243
Echinococcus multilocularis tyrosine protein kinase HCK 0.0088 0.013 0.013
Trichomonas vaginalis CAMK family protein kinase 0.0042 0.0015 1
Loa Loa (eye worm) hypothetical protein 0.0374 0.0853 0.1192
Echinococcus multilocularis neuropeptides capa receptor 0.0089 0.0133 0.0133
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.0038 0.0053
Schistosoma mansoni tyrosine kinase 0.0116 0.0203 0.0371
Brugia malayi protein-tyrosine kinase 0.0124 0.0221 0.0309
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus multilocularis N chimaerin 0.0043 0.0019 0.0019
Echinococcus granulosus neuropeptides capa receptor 0.0089 0.0133 0.0133
Echinococcus granulosus alpha 1A adrenergic receptor 0.0089 0.0133 0.0133
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0042 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.2204 0.5471 0.7642
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0053 0.0044 0.0062
Onchocerca volvulus Slit protein homolog 0.0057 0.0053 0.0096
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0089 0.0133 0.0243
Brugia malayi neuropeptide F receptor 0.0089 0.0133 0.0186
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0094 0.0146 0.0146
Echinococcus granulosus defective proboscis extension response 0.0109 0.0184 0.0184
Schistosoma mansoni serine/threonine protein kinase 0.0244 0.0525 0.096
Echinococcus multilocularis serotonin receptor 0.0089 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.0013
Echinococcus granulosus tm gpcr rhodopsin 0.0089 0.0133 0.0133
Brugia malayi Protein kinase domain containing protein 0.0288 0.0636 0.0889
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0374 0.0853 0.0853
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Entamoeba histolytica protein kinase domain containing protein 0.0042 0.0017 0.1266
Loa Loa (eye worm) hypothetical protein 0.0057 0.0053 0.0073
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0374 0.0853 0.1192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0133 0.0243
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0186 0.0378 0.0529
Onchocerca volvulus Neuropeptide F receptor homolog 0.0089 0.0133 0.0243
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.0133 0.0133
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0089 0.0133 0.0186
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0109 0.0184 0.0336
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0076 0.0101 0.0142
Brugia malayi Dopamine receptor 0.0089 0.0133 0.0186
Echinococcus granulosus titin 0.0043 0.0019 0.0019
Brugia malayi RhoGAP domain containing protein 0.0043 0.0019 0.0026
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0043 0.0019 0.0035
Loa Loa (eye worm) hypothetical protein 0.0108 0.0182 0.0254
Echinococcus multilocularis g protein coupled receptor 0.0089 0.0133 0.0133
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.0038 0.0053
Brugia malayi neuropeptide F receptor 0.0089 0.0133 0.0186
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0128 0.0231 0.0231
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0141 0.0265 0.0265
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0299 0.0664 0.0664
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0089 0.0133 0.0133
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0374 0.0853 0.156
Schistosoma mansoni growth factor receptor-bound protein 0.0053 0.0044 0.0081
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0128 0.0231 0.0231
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0075 0.0104
Brugia malayi Variant SH3 domain containing protein 0.0038 0.0004 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.0133 0.0133
Schistosoma mansoni neuropeptide receptor 0.0089 0.0133 0.0243
Echinococcus multilocularis serotonin transporter 0.2204 0.5471 0.5471
Brugia malayi Protein kinase domain containing protein 0.0267 0.0583 0.0814
Schistosoma mansoni sodium/chloride dependent transporter 0.0374 0.0853 0.156
Echinococcus multilocularis neuropeptide receptor 0.0089 0.0133 0.0133
Echinococcus granulosus serotonin receptor 0.0089 0.0133 0.0133
Schistosoma mansoni cell adhesion molecule 0.0051 0.0038 0.0069
Loa Loa (eye worm) hypothetical protein 0.0206 0.0429 0.0599
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0141 0.0265 0.0265
Echinococcus granulosus titin 0.0043 0.0019 0.0019
Echinococcus multilocularis tyrosine protein kinase shark 0.0488 0.1141 0.1141
Echinococcus granulosus 7TM GPCR rhodopsin 0.0089 0.0133 0.0133
Echinococcus multilocularis c src tyrosine kinase 0.0083 0.0119 0.0119
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0051 0.0038 0.0069
Echinococcus granulosus epidermal growth factor receptor 0.0146 0.0278 0.0278
Onchocerca volvulus 0.0374 0.0853 0.156
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0089 0.0133 0.0133
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0066 0.0075 0.0075
Schistosoma mansoni adenoreceptor 0.0089 0.0133 0.0243
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0089 0.0133 0.0133
Brugia malayi Melatonin receptor type 1A 0.0089 0.0133 0.0186
Echinococcus multilocularis neuroglian 0.0128 0.0233 0.0233
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0988 0.2402 0.3356
Echinococcus multilocularis tyrosine protein kinase otk 0.004 0.0009 0.0009
Echinococcus multilocularis activin receptor type 0.0042 0.0017 0.0017
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0043 0.0019 0.0026
Echinococcus multilocularis epidermal growth factor receptor 0.0146 0.0278 0.0278
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.0133 0.0133
Brugia malayi Immunoglobulin I-set domain containing protein 0.0147 0.028 0.0391
Schistosoma mansoni tyrosine kinase 0.0235 0.0502 0.0917
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Loa Loa (eye worm) TK protein kinase 0.0088 0.013 0.0182
Echinococcus multilocularis growth factor receptor bound protein 2 0.0053 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0066 0.0075 0.0104
Onchocerca volvulus 0.0089 0.0133 0.0243
Echinococcus multilocularis serotonin receptor 0.0089 0.0133 0.0133
Schistosoma mansoni vesicular amine transporter 0.0126 0.0228 0.0417
Echinococcus granulosus neuropeptide s receptor 0.0089 0.0133 0.0133
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0053 0.0044 0.0062
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0064 0.007 0.0098
Plasmodium falciparum protein kinase, putative 0.0042 0.0017 0.0001
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0042 0.0017 0.0017
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0089 0.0133 0.0243
Schistosoma mansoni biogenic amine (5HT) receptor 0.0089 0.0133 0.0243
Schistosoma mansoni tyrosine kinase 0.0224 0.0474 0.0867
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0133 0.0243
Onchocerca volvulus 0.0089 0.0133 0.0243
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0089 0.0133 0.0133
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0374 0.0853 0.1192
Echinococcus granulosus tyrosine protein kinase ABL1 0.0271 0.0593 0.0593
Brugia malayi Immunoglobulin I-set domain containing protein 0.004 0.0009 0.0013
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0089 0.0133 0.0186
Onchocerca volvulus 0.0089 0.0133 0.0243
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0374 0.0853 0.0853
Echinococcus granulosus twitchin 0.0141 0.0265 0.0265
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.0133 0.0133
Echinococcus granulosus neuropeptide receptor 0.0089 0.0133 0.0133
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0374 0.0853 0.156
Echinococcus granulosus tyrosine protein kinase Lyn 0.0154 0.0298 0.0298
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0374 0.0853 0.1192
Echinococcus granulosus NCK adaptor protein 0.0053 0.0044 0.0044
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0141 0.0265 0.0265
Plasmodium falciparum transporter, putative 0.0374 0.0853 0.0858
Echinococcus granulosus tachykinin peptides receptor 99D 0.0089 0.0133 0.0133
Schistosoma mansoni nck2/grb4 0.0053 0.0044 0.0081
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Loa Loa (eye worm) hypothetical protein 0.0142 0.0268 0.0374
Loa Loa (eye worm) hypothetical protein 0.0374 0.0853 0.1192
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0089 0.0133 0.0243
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0043 0.0019 0.0026
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0241 0.0519 0.0519
Schistosoma mansoni neuropeptide F-like receptor 0.0089 0.0133 0.0243
Echinococcus multilocularis roundabout 2 0.0051 0.0038 0.0038
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.0039 0.0072
Echinococcus multilocularis allatostatin A receptor 0.0089 0.0133 0.0133
Brugia malayi Immunoglobulin I-set domain containing protein 0.0076 0.0101 0.0142
Echinococcus granulosus g protein coupled receptor 0.0089 0.0133 0.0133
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0374 0.0853 0.0853
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0089 0.0133 0.0133
Schistosoma mansoni tyrosine kinase 0.0083 0.0119 0.0217
Onchocerca volvulus 0.0039 0.0008 0.0015
Echinococcus granulosus tyrosine kinase 0.0124 0.0221 0.0221
Schistosoma mansoni tyrosine kinase 0.0141 0.0265 0.0485
Toxoplasma gondii protein kinase, putative 0.3911 0.9779 1
Echinococcus multilocularis neuropeptides capa receptor 0.0089 0.0133 0.0133
Brugia malayi Protein kinase domain containing protein 0.0066 0.0075 0.0104
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.004 0.0009 0.0009
Schistosoma mansoni tyrosine kinase 0.0146 0.0278 0.0508
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0075 0.0104
Schistosoma mansoni biogenic amine receptor 0.0089 0.0133 0.0243
Loa Loa (eye worm) hypothetical protein 0.0109 0.0185 0.0259
Brugia malayi hypothetical protein 0.012 0.0212 0.0296
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0374 0.0853 0.0853
Echinococcus multilocularis Immunoglobulin 0.0109 0.0184 0.0184
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0075 0.0104
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0374 0.0853 0.0853
Echinococcus granulosus biogenic amine 5HT receptor 0.0089 0.0133 0.0133
Brugia malayi EGF-like domain containing protein 0.0057 0.0053 0.0073
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0042 0.0015 0.0015
Schistosoma mansoni tyrosine kinase 0.0116 0.0203 0.0371
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0141 0.0265 0.0265
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0374 0.0853 0.156
Plasmodium vivax amine transporter, putative 0.0374 0.0853 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.004 0.0009 0.0013
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0374 0.0853 0.0853
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.0133 0.0133
Loa Loa (eye worm) TK protein kinase 0.0124 0.0221 0.0309
Loa Loa (eye worm) serotonin transporter b 0.2204 0.5471 0.7642
Schistosoma mansoni tyrosine kinase 0.0488 0.1141 0.2085
Schistosoma mansoni cell adhesion molecule 0.004 0.0009 0.0017
Echinococcus multilocularis g protein coupled receptor 0.0089 0.0133 0.0133
Brugia malayi hypothetical protein 0.0089 0.0133 0.0186
Echinococcus granulosus neuropeptide receptor A26 0.0089 0.0133 0.0133
Brugia malayi G protein-coupled receptor F59B2.13 0.0089 0.0133 0.0186
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0038 0.0004 0.0006
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0051 0.0038 0.0053
Echinococcus multilocularis g protein coupled receptor 0.0089 0.0133 0.0133
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0141 0.0265 0.0265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0133 0.0243
Brugia malayi G-protein coupled receptor 0.0089 0.0133 0.0186
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0374 0.0853 0.5
Echinococcus multilocularis NCK adaptor protein 0.0053 0.0044 0.0044
Schistosoma mansoni protein kinase 0.0042 0.0015 0.0028
Echinococcus multilocularis hemicentin 1 0.004 0.0009 0.0009
Trypanosoma brucei protein kinase, putative 0.0042 0.0017 0.0005
Schistosoma mansoni tyrosine kinase 0.0288 0.0636 0.1163
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.0038 0.0053
Brugia malayi Peroxidasin 0.004 0.0011 0.0015
Echinococcus multilocularis neuropeptide receptor A26 0.0089 0.0133 0.0133
Loa Loa (eye worm) TYRA-2 protein 0.0089 0.0133 0.0186
Echinococcus multilocularis G-protein coupled receptor, putative 0.0089 0.0133 0.0133
Brugia malayi G-protein coupled receptor 0.0089 0.0133 0.0186
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.0013
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0374 0.0853 0.156
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0089 0.0133 0.0186
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0089 0.0133 0.0186
Brugia malayi ORL1-like opioid receptor 0.0089 0.0133 0.0186
Schistosoma mansoni nephrin 0.0139 0.0261 0.0477
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0053 0.0044 0.0081
Brugia malayi Prion-like- 0.004 0.0009 0.0013
Echinococcus granulosus N chimaerin 0.0043 0.0019 0.0019
Echinococcus granulosus tyrosine protein kinase Src64B 0.0141 0.0265 0.0265
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0089 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.012 0.0212 0.0296
Brugia malayi Raf kinase 0.0237 0.0506 0.0707
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0519 0.1218 0.1218
Schistosoma mansoni voltage-gated potassium channel 0.0186 0.0378 0.0692
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0089 0.0133 0.0243
Echinococcus granulosus fibroblast growth factor receptor 4 0.0128 0.0231 0.0231
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0089 0.0133 0.0133
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0075 0.0104
Brugia malayi hypothetical protein 0.0089 0.0133 0.0186
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0075 0.0104
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Schistosoma mansoni amine GPCR 0.0089 0.0133 0.0243
Echinococcus granulosus neuroglian 0.0128 0.0233 0.0233
Loa Loa (eye worm) TK/EGFR protein kinase 0.0146 0.0278 0.0388
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0042 0.0015 0.0015
Echinococcus granulosus tyrosine protein kinase 0.0267 0.0583 0.0583
Echinococcus granulosus tm gpcr rhodopsin 0.0089 0.0133 0.0133
Brugia malayi Serotonin receptor 0.0089 0.0133 0.0186
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0048 0.003 0.003
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0089 0.0133 0.0133
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0133 0.0243
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0089 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.1392 0.3422 0.478
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0141 0.0265 0.0265
Brugia malayi Immunoglobulin I-set domain containing protein 0.004 0.0009 0.0013
Schistosoma mansoni histamine h1 receptor 0.0089 0.0133 0.0243
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.0133 0.0133
Brugia malayi hypothetical protein 0.0089 0.0133 0.0186
Brugia malayi MH2 domain containing protein 0.0117 0.0204 0.0285
Loa Loa (eye worm) hypothetical protein 0.0209 0.0436 0.0609
Schistosoma mansoni tyrosine kinase 0.0116 0.0203 0.0371
Schistosoma mansoni tyrosine kinase 0.0141 0.0265 0.0485
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0042 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0991 0.241 0.241
Schistosoma mansoni alpha-1 adrenergic receptor 0.0089 0.0133 0.0243
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0089 0.0133 0.0243
Brugia malayi Immunoglobulin I-set domain containing protein 0.0468 0.109 0.1522
Echinococcus granulosus g-protein coupled receptor 0.0089 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.004 0.0011 0.0015
Brugia malayi Variant SH3 domain containing protein 0.0053 0.0044 0.0062
Schistosoma mansoni sodium/chloride dependent transporter 0.0387 0.0886 0.1619
Echinococcus multilocularis Immunoglobulin 0.0109 0.0184 0.0184
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0271 0.0593 0.0593
Schistosoma mansoni myosin xvIII 0.0089 0.0133 0.0243
Brugia malayi Variant SH3 domain containing protein 0.0043 0.0019 0.0026
Onchocerca volvulus 0.0374 0.0853 0.156
Loa Loa (eye worm) neuropeptide F receptor 0.0089 0.0133 0.0186
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0109 0.0184 0.0336
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0124 0.0221 0.0221
Echinococcus granulosus tyrosine protein kinase Src42A 0.0141 0.0265 0.0265
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.004 0.0009 0.0017
Brugia malayi sulfakinin receptor protein 0.0089 0.0133 0.0186
Onchocerca volvulus 0.0056 0.0051 0.0093
Echinococcus multilocularis tyrosine kinase 0.0066 0.0075 0.0075
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0089 0.0133 0.0133
Trypanosoma brucei C-8 sterol isomerase, putative 0.0988 0.2402 1
Echinococcus granulosus G protein coupled receptor 139 0.0089 0.0133 0.0133
Brugia malayi hypothetical protein 0.0066 0.0075 0.0104
Schistosoma mansoni cell adhesion molecule 0.0051 0.0038 0.0069
Brugia malayi AKH receptor 0.0089 0.0133 0.0186
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Onchocerca volvulus 0.0089 0.0133 0.0243
Echinococcus multilocularis dro:myosuppressin receptor 0.0089 0.0133 0.0133
Treponema pallidum sodium- and chloride- dependent transporter 0.2204 0.5471 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0049 0.0033 0.0033
Brugia malayi hypothetical protein 0.0089 0.0133 0.0186
Schistosoma mansoni amine GPCR 0.0089 0.0133 0.0243
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.0013
Loa Loa (eye worm) G-protein coupled receptor 0.0089 0.0133 0.0186
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus multilocularis orexin receptor type 2 0.0089 0.0133 0.0133
Echinococcus multilocularis roundabout 2 0.016 0.0312 0.0312
Schistosoma mansoni roundabout 0.004 0.0009 0.0017
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0043 0.0019 0.0019
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0374 0.0853 0.0858
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Schistosoma mansoni protein kinase 0.0042 0.0017 0.003
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0124 0.0221 0.0221
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0042 0.0017 0.0001
Loa Loa (eye worm) hypothetical protein 0.0129 0.0235 0.0329
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Onchocerca volvulus 0.0089 0.0133 0.0243
Brugia malayi Immunoglobulin I-set domain containing protein 0.012 0.0212 0.0296
Onchocerca volvulus 0.0066 0.0075 0.0136
Brugia malayi Immunoglobulin I-set domain containing protein 0.004 0.0009 0.0013
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0066 0.0075 0.5728
Loa Loa (eye worm) hypothetical protein 0.0988 0.2402 0.3356
Echinococcus granulosus roundabout 2 0.016 0.0312 0.0312
Loa Loa (eye worm) TK/ROR protein kinase 0.0049 0.0033 0.0046
Echinococcus multilocularis g-protein coupled receptor 0.0089 0.0133 0.0133
Onchocerca volvulus 0.0089 0.0133 0.0243
Schistosoma mansoni voltage-gated potassium channel 0.0186 0.0378 0.0692
Echinococcus granulosus tyrosine protein kinase Src42A 0.0094 0.0146 0.0146
Brugia malayi hypothetical protein 0.0374 0.0853 0.1192
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Schistosoma mansoni hypothetical protein 0.0089 0.0133 0.0243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0133 0.0243
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0042 0.0015 0.0021
Loa Loa (eye worm) TK/ABL protein kinase 0.0271 0.0593 0.0828
Echinococcus multilocularis tyrosine protein kinase Abl 0.0162 0.0317 0.0317
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0051 0.0038 0.0038
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0178 0.0358 0.0358
Brugia malayi protein unc-22 0.0043 0.0019 0.0026
Echinococcus granulosus g protein coupled receptor 0.0089 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0374 0.0853 0.1192
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0374 0.0853 0.0858
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0051 0.0038 0.0038
Echinococcus multilocularis neuropeptide Y receptor 0.0089 0.0133 0.0133
Onchocerca volvulus 0.0066 0.0075 0.0136
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0141 0.0265 0.0265
Echinococcus granulosus insulin receptor 0.0288 0.0636 0.0636
Onchocerca volvulus 0.0066 0.0075 0.0136
Schistosoma mansoni tyrosine kinase 0.0288 0.0636 0.1163
Echinococcus multilocularis peroxidasin 0.004 0.0011 0.0011
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0089 0.0133 0.0243
Brugia malayi Serotonin receptor 0.0089 0.0133 0.0186
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Schistosoma mansoni opsin-like receptor 0.0089 0.0133 0.0243
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0374 0.0853 0.156
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0374 0.0853 0.156
Echinococcus multilocularis potassium voltage gated channel protein 0.0186 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus granulosus hypothetical protein 0.0089 0.0133 0.0133
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0089 0.0133 0.0243
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0146 0.0278 0.0278
Schistosoma mansoni sodium-dependent amino acid transporter 0.0374 0.0853 0.156
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0519 0.1218 0.1218
Schistosoma mansoni biogenic amine receptor 0.0089 0.0133 0.0243
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Onchocerca volvulus 0.0089 0.0133 0.0243
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0519 0.1218 0.1702
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0204 0.0285
Echinococcus granulosus tyrosine kinase 0.0066 0.0075 0.0075
Onchocerca volvulus 0.0089 0.0133 0.0243
Schistosoma mansoni amine GPCR 0.0089 0.0133 0.0243
Loa Loa (eye worm) hypothetical protein 0.0042 0.0016 0.0023
Echinococcus granulosus sodium and chloride dependent glycine 0.0374 0.0853 0.0853
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Loa Loa (eye worm) hypothetical protein 0.0042 0.0015 0.0021
Echinococcus multilocularis raf serine:threonine protein kinase 0.0244 0.0525 0.0525
Toxoplasma gondii hypothetical protein 0.0374 0.0853 0.0858
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0089 0.0133 0.0243
Brugia malayi Protein kinase domain containing protein 0.0066 0.0075 0.0104
Echinococcus multilocularis sex peptide receptor 0.0089 0.0133 0.0133
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0089 0.0133 0.0133
Echinococcus multilocularis neuropeptide s receptor 0.0089 0.0133 0.0133
Brugia malayi RE15519p 0.0089 0.0133 0.0186
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0042 0.0017 0.0005
Onchocerca volvulus 0.0089 0.0133 0.0243
Echinococcus granulosus neuropeptides capa receptor 0.0089 0.0133 0.0133
Loa Loa (eye worm) TK protein kinase 0.0267 0.0583 0.0814
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0241 0.0519 0.0519
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.2204 0.5471 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0089 0.0133 0.0243
Echinococcus granulosus serotonin transporter 0.2204 0.5471 0.5471
Onchocerca volvulus 0.0089 0.0133 0.0243
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0042 0.0015 0.0015
Schistosoma mansoni tyrosine kinase 0.0128 0.0231 0.0423
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0109 0.0184 0.0257
Brugia malayi Variant SH3 domain containing protein 0.0053 0.0044 0.0062
Loa Loa (eye worm) hypothetical protein 0.0149 0.0284 0.0397
Schistosoma mansoni growth factor receptor-bound protein 0.0053 0.0044 0.0081
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus granulosus g protein coupled receptor 0.0089 0.0133 0.0133
Echinococcus granulosus rhodopsin orphan GPCR 0.0089 0.0133 0.0133
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.0039 0.0072
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0204 0.0285
Plasmodium falciparum protein kinase 7 0.3911 0.9779 1
Schistosoma mansoni septate junction protein 0.004 0.0009 0.0017
Schistosoma mansoni protein kinase 0.0042 0.0017 0.003
Echinococcus granulosus somatostatin receptor 0.0089 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0149 0.0284 0.0397
Echinococcus multilocularis titin 0.0043 0.0019 0.0019
Brugia malayi Immunoglobulin I-set domain containing protein 0.004 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.2204 0.5471 0.7642
Echinococcus multilocularis fmrfamide receptor 0.0089 0.0133 0.0133
Onchocerca volvulus 0.0066 0.0075 0.0136
Brugia malayi SH2 domain containing protein 0.0066 0.0075 0.0104
Loa Loa (eye worm) hypothetical protein 0.0374 0.0853 0.1192
Leishmania major protein kinase, putative 0.0042 0.0017 0.0005
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0151 0.029 0.0405
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0075 0.0104
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0043 0.0019 0.0019
Schistosoma mansoni amine GPCR 0.0089 0.0133 0.0243
Brugia malayi Protein kinase domain containing protein 0.0519 0.1218 0.1702
Brugia malayi G protein-coupled receptor 0.0089 0.0133 0.0186
Brugia malayi SRC-1 0.0141 0.0265 0.0371
Schistosoma mansoni biogenic amine receptor 0.0089 0.0133 0.0243
Echinococcus granulosus dro:myosuppressin receptor 0.0089 0.0133 0.0133
Echinococcus granulosus lachesin 0.004 0.0009 0.0009
Echinococcus granulosus contactin 0.0051 0.0038 0.0038
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0042 0.0015 0.0015
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0019 0.0035
Echinococcus granulosus epidermal growth factor receptor 0.0146 0.0278 0.0278
Onchocerca volvulus 0.0089 0.0133 0.0243
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Brugia malayi Immunoglobulin I-set domain containing protein 0.0043 0.0019 0.0026
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0049 0.0033 0.2499
Onchocerca volvulus 0.0089 0.0133 0.0243
Leishmania major C-8 sterol isomerase-like protein 0.0988 0.2402 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0048 0.003 0.003
Onchocerca volvulus Basement membrane proteoglycan homolog 0.004 0.0009 0.0017
Echinococcus multilocularis insulin receptor 0.0288 0.0636 0.0636
Echinococcus granulosus peroxidasin 0.004 0.0011 0.0011
Brugia malayi GnHR receptor homolog 0.0089 0.0133 0.0186
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0141 0.0265 0.0265
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0519 0.1218 0.1702
Schistosoma mansoni protein kinase 0.0042 0.0015 0.0028
Echinococcus multilocularis tyrosine protein kinase Srms 0.0124 0.0221 0.0221
Entamoeba histolytica protein kinase, putative 0.0049 0.0033 0.2499
Loa Loa (eye worm) hypothetical protein 0.1392 0.3422 0.478
Echinococcus granulosus neuroglian 0.0051 0.0038 0.0038
Brugia malayi Furin-like cysteine rich region family protein 0.0146 0.0278 0.0388
Echinococcus multilocularis neuropeptide FF receptor 2 0.0089 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Echinococcus multilocularis somatostatin receptor 0.0089 0.0133 0.0133
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0299 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.004 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0053
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0042 0.0017 0.0017
Echinococcus multilocularis sodium and chloride dependent glycine 0.0374 0.0853 0.0853
Schistosoma mansoni titin 0.0043 0.0019 0.0035
Echinococcus granulosus activin receptor type 0.0042 0.0017 0.0017
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0089 0.0133 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.0047 0.0028 0.0051
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0089 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0038 0.0004 0.0006
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0089 0.0133 0.0133
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0042 0.0015 0.0021
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0049 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0089 0.0133 0.0186
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.0133 0.0133
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0075 0.0104
Loa Loa (eye worm) hypothetical protein 0.0374 0.0853 0.1192
Onchocerca volvulus 0.0374 0.0853 0.156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0089 0.0133 0.0133
Loa Loa (eye worm) TK protein kinase 0.0147 0.028 0.0391
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0988 0.2402 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0141 0.0265 0.0265
Schistosoma mansoni tyrosine kinase 0.0083 0.0119 0.0217
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0048 0.003 0.0042
Echinococcus granulosus peptide allatostatin:somatostatin 0.0089 0.0133 0.0133
Echinococcus granulosus sodium and chloride dependent glycine 0.0374 0.0853 0.0853
Echinococcus multilocularis hemicentin 1 0.004 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0089 0.0133 0.0243
Echinococcus multilocularis G protein coupled receptor 139 0.0089 0.0133 0.0133
Echinococcus multilocularis roundabout 2 0.0051 0.0038 0.0038
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0186 0.0378 0.0378
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0089 0.0133 0.0186
Loa Loa (eye worm) hypothetical protein 0.0089 0.0133 0.0186
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0083 0.0119 0.0217

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 27 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 ChEMBL. 17112640
IC50 (functional) = 27 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 ChEMBL. 17112640
IC50 (functional) = 37 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 ChEMBL. 17112640
IC50 (functional) = 37 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 ChEMBL. 17112640
Inhibition (binding) = 83 % Inhibition of Plasmodium falciparum recombinant superoxide dismutase at 50 uM ChEMBL. 17112640
Inhibition (binding) = 83 % Inhibition of Plasmodium falciparum recombinant superoxide dismutase at 50 uM ChEMBL. 17112640

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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