Detailed information for compound 511106

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 337.363 | Formula: C16H14F3N3S
  • H donors: 2 H acceptors: 0 LogP: 4.33 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=S)N/N=C(\c1cccc(c1)C(F)(F)F)/c1ccc(cc1)C
  • InChi: 1S/C16H14F3N3S/c1-10-5-7-11(8-6-10)14(21-22-15(20)23)12-3-2-4-13(9-12)16(17,18)19/h2-9H,1H3,(H3,20,22,23)/b21-14-
  • InChiKey: CTYIIVFLDQCJPG-STZFKDTASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.00173822 0.0956339 0.0950719
Plasmodium falciparum serine repeat antigen 1 0.000995025 0.036454 0.16991
Onchocerca volvulus 0.00230221 0.140544 0.594595
Entamoeba histolytica cysteine proteinase, putative 0.00319348 0.211514 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.00173822 0.0956339 0.149383
Loa Loa (eye worm) cathepsin B 0.00597015 0.432617 0.430524
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.000995025 0.036454 0.0358552
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.00173822 0.0956339 0.149383
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.00173822 0.0956339 0.149383
Giardia lamblia Hypothetical protein 0.000995025 0.036454 0.0842639
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.000995025 0.036454 0.0358552
Echinococcus multilocularis multidrug resistance associated protein 1 0.001033 0.0394775 0.0388806
Entamoeba histolytica cysteine protease, putative 0.00188629 0.107424 0.506433
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.211514 0.441889
Echinococcus multilocularis cathepsin l cysteine peptidase 0.00319348 0.211514 0.211024
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.000995025 0.036454 0.16991
Echinococcus multilocularis cathepsin L cysteine protease 0.00319348 0.211514 0.211024
Leishmania major ABC-thiol transporter 0.001033 0.0394775 0.0899465
Giardia lamblia Dipeptidyl-peptidase I precursor 0.000995025 0.036454 0.0842639
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.00173822 0.0956339 0.0950719
Loa Loa (eye worm) hypothetical protein 0.000995025 0.036454 0.0328995
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.00173822 0.0956339 0.149383
Brugia malayi Cathepsin L-like precursor 0.00319348 0.211514 0.18864
Entamoeba histolytica cysteine proteinase, putative 0.00230221 0.140544 0.663477
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.211514 0.441889
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.000995025 0.036454 0.16991
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.00173822 0.0956339 0.149383
Giardia lamblia Dipeptidyl-peptidase I precursor 0.000995025 0.036454 0.0842639
Giardia lamblia MRP-like ABC transporter 0.001033 0.0394775 0.091253
Brugia malayi cahepsin L-like non-peptiedase homolog 0.000995025 0.036454 0.0085019
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.000545025 0.000621065 0.5
Loa Loa (eye worm) hypothetical protein 0.00173822 0.0956339 0.0922978
Trypanosoma cruzi cruzipain precursor, putative 0.00319348 0.211514 0.211024
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.000995025 0.036454 0.16991
Loa Loa (eye worm) hypothetical protein 0.00173043 0.0950129 0.0916744
Trypanosoma cruzi cruzipain precursor, putative 0.000891266 0.0281917 0.0275878
Brugia malayi Papain family cysteine protease containing protein 0.00188629 0.107424 0.081531
Giardia lamblia Cathepsin L precursor 0.000995025 0.036454 0.0842639
Loa Loa (eye worm) papain family cysteine protease containing protein 0.00319348 0.211514 0.208605
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.00173822 0.0956339 0.149383
Plasmodium falciparum cysteine proteinase falcipain 1 0.00188629 0.107424 0.506433
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.000995025 0.036454 0.0842639
Plasmodium vivax unspecified product 0.000891266 0.0281917 0.130733
Toxoplasma gondii cathepsin CPC2 0.000995025 0.036454 0.0829474
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.211514 0.441889
Schistosoma mansoni multidrug resistance protein 0.00173822 0.0956339 0.0950719
Entamoeba histolytica P-glycoprotein-2 0.00173822 0.0956339 0.450526
Echinococcus multilocularis cathepsin L 0.000995025 0.036454 0.0358552
Leishmania major cathepsin L-like protease 0.00319348 0.211514 0.488183
Echinococcus granulosus multidrug resistance associated protein 1 0.001033 0.0394775 0.0388806
Echinococcus granulosus cathepsin l cysteine peptidase 0.00319348 0.211514 0.211024
Loa Loa (eye worm) hypothetical protein 0.00230221 0.140544 0.137373
Plasmodium falciparum serine repeat antigen 6 0.000995025 0.036454 0.16991
Plasmodium falciparum serine repeat antigen 2 0.000995025 0.036454 0.16991
Onchocerca volvulus 0.00319348 0.211514 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00188629 0.107424 0.179144
Entamoeba histolytica papain family cysteine protease domain containing protein 0.000995025 0.036454 0.16991
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.001033 0.0394775 0.0899465
Onchocerca volvulus 0.00319348 0.211514 1
Leishmania major cathepsin L-like protease 0.00319348 0.211514 0.488183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.211514 0.441889
Brugia malayi cathepsin L precursor 0.000995025 0.036454 0.0085019
Loa Loa (eye worm) hypothetical protein 0.001033 0.0394775 0.0359343
Plasmodium vivax unspecified product 0.00188629 0.107424 0.506433
Echinococcus granulosus cathepsin L 0.000995025 0.036454 0.0358552
Brugia malayi Papain family cysteine protease containing protein 0.00188629 0.107424 0.081531
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00188629 0.107424 0.10687
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00230221 0.140544 0.262745
Brugia malayi cathepsin Z-like cysteine proteinase 0.000995025 0.036454 0.0085019
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00173822 0.0956339 0.0950719
Giardia lamblia Cathepsin B precursor 0.00597015 0.432617 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.00319348 0.211514 0.441889
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.00173822 0.0956339 0.149383
Entamoeba histolytica P-glycoprotein-2, putative 0.00173822 0.0956339 0.450526
Echinococcus granulosus cathepsin L cysteine protease 0.00188629 0.107424 0.10687
Giardia lamblia Multidrug resistance-associated protein 1 0.001033 0.0394775 0.091253
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.00173822 0.0956339 0.149383
Plasmodium falciparum serine repeat antigen 3 0.000995025 0.036454 0.16991
Echinococcus granulosus cathepsin b 0.0130955 1 1
Echinococcus multilocularis cathepsin b 0.0130955 1 1
Entamoeba histolytica cysteine protease, putative 0.00188629 0.107424 0.506433
Entamoeba histolytica ATP-binding cassette protein, putative 0.001033 0.0394775 0.184247
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.00597015 0.432617 0.432264
Loa Loa (eye worm) hypothetical protein 0.000891266 0.0281917 0.0246068
Trypanosoma cruzi cysteine peptidase, putative 0.00319348 0.211514 0.211024
Plasmodium falciparum serine repeat antigen 4 0.000995025 0.036454 0.16991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.211514 0.441889
Echinococcus granulosus multidrug resistance associated protein 7 0.001033 0.0394775 0.0388806
Onchocerca volvulus 0.00319348 0.211514 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.00319348 0.211514 0.211024
Brugia malayi Cathepsin L-like precursor 0.00319348 0.211514 0.18864
Loa Loa (eye worm) multidrug resistance protein 3 0.00173822 0.0956339 0.0922978
Schistosoma mansoni cathepsin F (C01 family) 0.00230221 0.140544 0.14001
Loa Loa (eye worm) hypothetical protein 0.000995025 0.036454 0.0328995
Entamoeba histolytica cysteine protease, putative 0.00319348 0.211514 1
Leishmania major cathepsin L-like protease 0.00319348 0.211514 0.488183
Toxoplasma gondii cathepsin CPL 0.00319348 0.211514 0.488183
Onchocerca volvulus 0.00319348 0.211514 1
Giardia lamblia Hypothetical protein 0.000995025 0.036454 0.0842639
Brugia malayi cathepsin B-like cysteine proteinase 0.0130955 1 1
Leishmania major pentamidine resistance protein 1 0.001033 0.0394775 0.0899465
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.00230221 0.140544 0.14001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.211514 0.441889
Echinococcus granulosus multidrug resistance protein 1 0.00128861 0.0598318 0.0592475
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.001033 0.0394775 0.0899465
Plasmodium falciparum serine repeat antigen 8 0.000995025 0.036454 0.16991
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00188629 0.107424 0.247232
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.00173822 0.0956339 0.21994
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.211514 0.441889
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.000995025 0.036454 0.16991
Giardia lamblia Cathepsin L precursor 0.000995025 0.036454 0.0842639
Brugia malayi cathepsin L-like cysteine proteinase 0.000995025 0.036454 0.0085019
Schistosoma mansoni cathepsin B (C01 family) 0.000995025 0.036454 0.0358552
Loa Loa (eye worm) papain family cysteine protease containing protein 0.000891266 0.0281917 0.0246068
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.000545025 0.000621065 0.5
Giardia lamblia Cathepsin L precursor 0.000995025 0.036454 0.0842639
Entamoeba histolytica cysteine proteinase 2 0.00188629 0.107424 0.506433
Giardia lamblia Cathepsin B precursor 0.000995025 0.036454 0.0842639
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00188629 0.107424 0.247232
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.000995025 0.036454 0.0358552
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.211514 0.488183
Trichomonas vaginalis ABC transporter, putative 0.00173822 0.0956339 0.149383
Giardia lamblia Cysteine protease 0.000995025 0.036454 0.0842639
Onchocerca volvulus 0.00319348 0.211514 1
Giardia lamblia Encystation-specific protease 0.000995025 0.036454 0.0842639
Brugia malayi cathepsin F-like cysteine proteinase 0.000995025 0.036454 0.0085019
Brugia malayi Cathepsin L-like precursor 0.00230221 0.140544 0.115611
Echinococcus granulosus cysteine protease 0.00188629 0.107424 0.10687
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.00188629 0.107424 0.10687
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.00173822 0.0956339 0.149383
Entamoeba histolytica multidrug resistance protein, putative 0.001033 0.0394775 0.184247
Plasmodium falciparum serine repeat antigen 7 0.000995025 0.036454 0.16991
Trypanosoma brucei multidrug resistance protein E 0.001033 0.0394775 0.0899465
Trichomonas vaginalis taga, putative 0.00173822 0.0956339 0.149383
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.00173822 0.0956339 0.5
Giardia lamblia Dipeptidyl-peptidase I precursor 0.000995025 0.036454 0.0842639
Schistosoma mansoni smdr2 0.00173822 0.0956339 0.0950719
Schistosoma mansoni multidrug resistance protein 0.00173822 0.0956339 0.0950719
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.000995025 0.036454 0.16991
Schistosoma mansoni cathepsin C 0.000995025 0.036454 0.0358552
Echinococcus granulosus cathepsin l1 0.00230221 0.140544 0.14001
Plasmodium falciparum cysteine proteinase falcipain 2a 0.00319348 0.211514 1
Echinococcus multilocularis multidrug resistance protein 1 0.00173822 0.0956339 0.0950719
Entamoeba histolytica cysteine protease, putative 0.00188629 0.107424 0.506433
Entamoeba histolytica cysteine protease, putative 0.00188629 0.107424 0.506433
Giardia lamblia Cathepsin L precursor 0.000995025 0.036454 0.0842639
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.00597015 0.432617 1
Entamoeba histolytica cysteine protease, putative 0.000995025 0.036454 0.16991
Entamoeba histolytica cysteine proteinase, putative 0.00188629 0.107424 0.506433
Entamoeba histolytica cysteine proteinase, putative 0.00319348 0.211514 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.00173822 0.0956339 0.149383
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.211514 0.488183
Loa Loa (eye worm) fibroinase 0.00319348 0.211514 0.208605
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.211514 0.488183
Giardia lamblia Cathepsin B precursor 0.000995025 0.036454 0.0842639
Entamoeba histolytica cysteine protease, putative 0.000995025 0.036454 0.16991
Entamoeba histolytica hypothetical protein 0.001033 0.0394775 0.184247
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.00173822 0.0956339 0.149383
Brugia malayi ABC transporter transmembrane region family protein 0.001033 0.0394775 0.0116132
Plasmodium vivax serine-repeat antigen (SERA), putative 0.000995025 0.036454 0.16991
Loa Loa (eye worm) hypothetical protein 0.000995025 0.036454 0.0328995
Entamoeba histolytica ATP-binding cassette protein, putative 0.001033 0.0394775 0.184247
Echinococcus granulosus cathepsin l1 0.00319348 0.211514 0.211024
Leishmania major p-glycoprotein e 0.001033 0.0394775 0.0899465
Plasmodium vivax serine-repeat antigen (SERA), putative 0.000995025 0.036454 0.16991
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.00173822 0.0956339 0.149383
Loa Loa (eye worm) hypothetical protein 0.001033 0.0394775 0.0359343
Entamoeba histolytica cysteine protease, putative 0.000995025 0.036454 0.16991
Brugia malayi multidrug resistance related protein 1 0.001033 0.0394775 0.0116132
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.00173822 0.0956339 0.149383
Echinococcus multilocularis multidrug resistance associated protein 7 0.001033 0.0394775 0.0388806
Trypanosoma cruzi cysteine peptidase, putative 0.00319348 0.211514 0.211024
Plasmodium falciparum serine repeat antigen 5 0.000995025 0.036454 0.16991
Giardia lamblia Cathepsin L precursor 0.000995025 0.036454 0.0842639
Giardia lamblia Cysteine protease 0.000995025 0.036454 0.0842639
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.000995025 0.036454 0.0358552
Echinococcus multilocularis cathepsin b 0.0130955 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.000995025 0.036454 0.0085019
Brugia malayi fibroinase precursor 0.000995025 0.036454 0.0085019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.211514 0.441889
Trypanosoma cruzi cysteine peptidase, putative 0.00188629 0.107424 0.10687
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.000995025 0.036454 0.16991
Trypanosoma cruzi multidrug resistance protein E, putative 0.001033 0.0394775 0.0388806
Entamoeba histolytica P-glycoprotein 5, putative 0.00173822 0.0956339 0.450526
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00173822 0.0956339 0.0950719
Leishmania major cathepsin L-like protease 0.00319348 0.211514 0.488183
Brugia malayi Papain family cysteine protease containing protein 0.000995025 0.036454 0.0085019
Entamoeba histolytica cysteine protease, putative 0.00188629 0.107424 0.506433
Echinococcus granulosus cathepsin L 0.00188629 0.107424 0.10687
Giardia lamblia Cathepsin L-like protease 0.000995025 0.036454 0.0842639
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.211514 0.488183
Loa Loa (eye worm) ctsf protein 0.00319348 0.211514 0.208605
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.211514 0.441889
Trypanosoma cruzi cysteine peptidase, putative 0.00319348 0.211514 0.211024
Giardia lamblia Cathepsin B precursor 0.00597015 0.432617 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.00173822 0.0956339 0.21994
Leishmania major p-glycoprotein 0.00173822 0.0956339 0.21994
Schistosoma mansoni multidrug resistance protein 0.001033 0.0394775 0.0388806
Brugia malayi Cathepsin L-like cysteine proteinase 0.00230221 0.140544 0.115611
Entamoeba histolytica cysteine proteinase, putative 0.00188629 0.107424 0.506433
Trypanosoma cruzi hypothetical protein 0.000575582 0.0030543 0.00243475
Trichomonas vaginalis abcb9, putative 0.00173822 0.0956339 0.149383
Trypanosoma brucei p-glycoprotein 0.001033 0.0394775 0.0899465
Giardia lamblia Cysteine protease 0.000995025 0.036454 0.0842639
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.211514 0.441889
Leishmania major cathepsin L-like protease 0.00319348 0.211514 0.488183
Brugia malayi Papain family cysteine protease containing protein 0.000995025 0.036454 0.0085019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.211514 0.488183
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.001033 0.0394775 0.0388806
Trypanosoma cruzi major cysteine proteinase, putative 0.000995025 0.036454 0.0358552
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.001033 0.0394775 0.0388806
Plasmodium vivax serine-repeat antigen (SERA) 0.000995025 0.036454 0.16991
Echinococcus granulosus multidrug resistance protein 1 0.00173822 0.0956339 0.0950719
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.000995025 0.036454 0.0358552
Entamoeba histolytica ABC transporter, putative 0.001033 0.0394775 0.184247
Trypanosoma cruzi cysteine peptidase, putative 0.00319348 0.211514 0.211024
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00173822 0.0956339 0.0950719
Loa Loa (eye worm) hypothetical protein 0.00230221 0.140544 0.137373
Echinococcus granulosus multidrug resistance associated protein 4 0.000575582 0.0030543 0.00243475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00230221 0.140544 0.262745
Plasmodium vivax unspecified product 0.000995025 0.036454 0.16991
Toxoplasma gondii cathepsin CPC1 0.000995025 0.036454 0.0829474
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00173822 0.0956339 0.0950719
Giardia lamblia Cathepsin L-like protease 0.000995025 0.036454 0.0842639
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.211514 0.441889
Echinococcus multilocularis ATP binding cassette sub family B 0.00173043 0.0950129 0.0944505
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.211514 0.488183
Entamoeba histolytica P-glycoprotein-2 0.00173822 0.0956339 0.450526
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.211514 0.441889
Echinococcus multilocularis cathepsin l cysteine peptidase 0.00319348 0.211514 0.211024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.211514 0.488183
Schistosoma mansoni multidrug resistance protein 0.001033 0.0394775 0.0388806
Plasmodium falciparum cysteine proteinase falcipain 3 0.00319348 0.211514 1
Brugia malayi multidrug resistance protein 3 0.00173822 0.0956339 0.0693987
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.211514 0.441889
Plasmodium falciparum cysteine proteinase falcipain 2b 0.00319348 0.211514 1
Leishmania major cathepsin L-like protease 0.00319348 0.211514 0.488183
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.00173822 0.0956339 0.149383
Brugia malayi Cathepsin L-like precursor 0.00319348 0.211514 0.18864
Brugia malayi Cathepsin L-like precursor 0.00319348 0.211514 0.18864
Trichomonas vaginalis ABC transporter, putative 0.00173822 0.0956339 0.149383
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.001033 0.0394775 0.0899465
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.211514 0.441889
Brugia malayi Cathepsin L-like precursor 0.00230221 0.140544 0.115611
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.00597015 0.432617 1
Entamoeba histolytica cysteine proteinase 1, putative 0.00188629 0.107424 0.506433
Entamoeba histolytica cysteine protease, putative 0.00188629 0.107424 0.506433
Trichomonas vaginalis ABC transporter, putative 0.00173822 0.0956339 0.149383
Schistosoma mansoni cathepsin s 0.000891266 0.0281917 0.0275878
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.00173822 0.0956339 0.5
Onchocerca volvulus 0.00319348 0.211514 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.211514 0.441889
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.00173822 0.0956339 0.149383
Giardia lamblia Cysteine protease 0.000995025 0.036454 0.0842639
Brugia malayi Cathepsin L-like precursor 0.00319348 0.211514 0.18864
Plasmodium falciparum serine repeat antigen 9 0.000995025 0.036454 0.16991
Plasmodium vivax multidrug resistance protein 1, putative 0.00173822 0.0956339 0.450526
Trichomonas vaginalis ABC transporter, half transporter, putative 0.00173822 0.0956339 0.149383
Entamoeba histolytica P-glycoprotein-5 0.00173822 0.0956339 0.450526
Loa Loa (eye worm) hypothetical protein 0.000995025 0.036454 0.0328995
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0130955 1 1
Loa Loa (eye worm) hypothetical protein 0.000891266 0.0281917 0.0246068
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.000995025 0.036454 0.16991
Echinococcus granulosus multidrug resistance protein 1 0.00173822 0.0956339 0.0950719
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.211514 0.488183
Onchocerca volvulus Cathepsin L homolog 0.00319348 0.211514 1
Loa Loa (eye worm) hypothetical protein 0.0130955 1 1
Entamoeba histolytica cysteine proteinase, putative 0.00188629 0.107424 0.506433
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.001033 0.0394775 0.0359343
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.000995025 0.036454 0.0358552
Schistosoma mansoni multidrug resistance protein 0.001033 0.0394775 0.0388806
Echinococcus multilocularis multidrug resistance protein 1 0.00128861 0.0598318 0.0592475
Plasmodium vivax vivapain-3 0.00188629 0.107424 0.506433
Echinococcus multilocularis cathepsin L 0.00188629 0.107424 0.10687
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.000995025 0.036454 0.0328995
Entamoeba histolytica cysteine protease, putative 0.00188629 0.107424 0.506433
Entamoeba histolytica cysteine protease, putative 0.00188629 0.107424 0.506433
Entamoeba histolytica ATP-binding cassette protein, putative 0.001033 0.0394775 0.184247
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.000545025 0.000621065 0.5
Loa Loa (eye worm) hypothetical protein 0.0010252 0.0388565 0.0353109
Trypanosoma brucei multidrug resistance-associated protein, putative 0.001033 0.0394775 0.0899465
Trypanosoma cruzi cysteine protease, putative 0.00188629 0.107424 0.10687
Leishmania major cathepsin L-like protease 0.00319348 0.211514 0.488183
Brugia malayi ABC transporter family protein 0.00173822 0.0956339 0.0693987
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00188629 0.107424 0.179144
Giardia lamblia Cathepsin B precursor 0.00597015 0.432617 1
Brugia malayi cathepsin L-like precursor 0.00230221 0.140544 0.115611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.211514 0.441889
Giardia lamblia Cathepsin B precursor 0.000995025 0.036454 0.0842639
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0130955 1 1
Giardia lamblia Multidrug resistance-associated protein 1 0.001033 0.0394775 0.091253
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.00319348 0.211514 0.441889
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.211514 0.441889
Giardia lamblia Multidrug resistance-associated protein 1 0.0010252 0.0388565 0.0898174
Trichomonas vaginalis ABC transporter, half transporter, putative 0.00173822 0.0956339 0.149383
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.211514 0.441889
Onchocerca volvulus 0.00319348 0.211514 1
Schistosoma mansoni cathepsin F (C01 family) 0.00319348 0.211514 0.211024
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.00173822 0.0956339 0.149383
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.00319348 0.211514 0.208605
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.001033 0.0394775 0.0899465
Giardia lamblia Cathepsin B precursor 0.000995025 0.036454 0.0842639
Brugia malayi Papain family cysteine protease containing protein 0.00319348 0.211514 0.18864
Plasmodium falciparum multidrug resistance protein 1 0.00173822 0.0956339 0.450526
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.00173822 0.0956339 0.149383
Trypanosoma brucei multidrug resistance-associated protein, putative 0.001033 0.0394775 0.0899465
Schistosoma mansoni cathepsin F (C01 family) 0.00319348 0.211514 0.211024
Onchocerca volvulus Cathepsin L homolog 0.00319348 0.211514 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.00173822 0.0956339 0.149383
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.00597015 0.432617 0.432264
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.001033 0.0394775 0.0899465
Plasmodium vivax vivapain-1 0.00188629 0.107424 0.506433
Echinococcus multilocularis cathepsin L cysteine protease 0.00319348 0.211514 0.211024
Toxoplasma gondii cathepsin B 0.00597015 0.432617 1
Schistosoma mansoni cathepsin S (C01 family) 0.000995025 0.036454 0.0358552
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.00173822 0.0956339 0.0950719
Echinococcus granulosus multidrug resistance protein 1 0.00173822 0.0956339 0.0950719
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.211514 0.488183
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.00173822 0.0956339 0.0950719
Loa Loa (eye worm) hypothetical protein 0.000995025 0.036454 0.0328995
Leishmania major cysteine peptidase A (CPA) 0.00319348 0.211514 0.488183
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.000995025 0.036454 0.0358552
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.00173822 0.0956339 0.149383
Loa Loa (eye worm) papain family cysteine protease containing protein 0.000995025 0.036454 0.0328995
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.000995025 0.036454 0.0358552
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.211514 0.488183
Trichomonas vaginalis ABC transporter, putative 0.00173822 0.0956339 0.149383
Trypanosoma cruzi cysteine peptidase, putative 0.000891266 0.0281917 0.0275878
Leishmania major cathepsin L-like protease 0.00319348 0.211514 0.488183
Entamoeba histolytica cysteine protease, putative 0.00188629 0.107424 0.506433
Giardia lamblia ABC transporter, putative 0.001033 0.0394775 0.091253
Trichomonas vaginalis abcb9, putative 0.00173822 0.0956339 0.149383
Trypanosoma brucei cysteine peptidase C (CPC) 0.00597015 0.432617 1
Entamoeba histolytica P-glycoprotein-1 0.00173822 0.0956339 0.450526
Echinococcus multilocularis multidrug resistance protein 1 0.00173822 0.0956339 0.0950719
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.000995025 0.036454 0.0358552
Entamoeba histolytica cysteine protease, putative 0.00188629 0.107424 0.506433
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.00173822 0.0956339 0.0922978
Schistosoma mansoni multidrug resistance protein 0.001033 0.0394775 0.0388806
Entamoeba histolytica cysteine protease, putative 0.000995025 0.036454 0.16991
Echinococcus multilocularis cysteine protease 0.00319348 0.211514 0.211024
Plasmodium vivax vivapain-2 0.00319348 0.211514 1
Loa Loa (eye worm) hypothetical protein 0.000995025 0.036454 0.0328995
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00188629 0.107424 0.10687
Onchocerca volvulus Cathepsin F homolog 0.00319348 0.211514 1
Echinococcus multilocularis multidrug resistance associated protein 4 0.000575582 0.0030543 0.00243475
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.00319348 0.211514 0.488183
Echinococcus granulosus multidrug resistance protein 1 0.00128861 0.0598318 0.0592475
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.00173822 0.0956339 0.21994
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.000995025 0.036454 0.16991
Trypanosoma cruzi major cysteine proteinase, putative 0.000995025 0.036454 0.0358552
Loa Loa (eye worm) cysteine protease 0.00319348 0.211514 0.208605
Brugia malayi Cathepsin L-like precursor 0.00319348 0.211514 0.18864
Trypanosoma cruzi cysteine proteinase, putative 0.00188629 0.107424 0.10687
Giardia lamblia Cathepsin L precursor 0.000995025 0.036454 0.0842639
Echinococcus granulosus cathepsin b 0.0130955 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.000995025 0.036454 0.0328995
Plasmodium vivax serine-repeat antigen (SERA) 0.000995025 0.036454 0.16991
Loa Loa (eye worm) hypothetical protein 0.000891266 0.0281917 0.0246068
Loa Loa (eye worm) hypothetical protein 0.00319348 0.211514 0.208605
Echinococcus multilocularis cysteine protease 0.00319348 0.211514 0.211024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.211514 0.441889
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.000995025 0.036454 0.16991
Plasmodium vivax vivapain-2 0.00319348 0.211514 1
Giardia lamblia Cathepsin B precursor 0.000995025 0.036454 0.0842639
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.00128861 0.0598318 0.0590106
Entamoeba histolytica cysteine protease, putative 0.00188629 0.107424 0.506433
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.211514 0.441889
Onchocerca volvulus 0.00173822 0.0956339 0.338055
Entamoeba histolytica papain family cysteine protease domain containing protein 0.000995025 0.036454 0.16991
Loa Loa (eye worm) hypothetical protein 0.00230221 0.140544 0.137373
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.000995025 0.036454 0.16991
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.00173822 0.0956339 0.149383
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0130955 1 1
Loa Loa (eye worm) hypothetical protein 0.00173822 0.0956339 0.0922978
Entamoeba histolytica cysteine protease, putative 0.00188629 0.107424 0.506433
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.211514 0.441889
Trypanosoma cruzi cysteine proteinase, putative 0.00188629 0.107424 0.10687
Entamoeba histolytica cysteine proteinase, putative 0.00188629 0.107424 0.506433
Entamoeba histolytica ATP-binding cassette protein, putative 0.001033 0.0394775 0.184247
Toxoplasma gondii preprocathepsin c precursor, putative 0.000995025 0.036454 0.0829474
Entamoeba histolytica cysteine protease, putative 0.000995025 0.036454 0.16991
Entamoeba histolytica hypothetical protein 0.000995025 0.036454 0.16991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.00319348 0.211514 0.441889
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0130955 1 1
Entamoeba histolytica cysteine protease, putative 0.00188629 0.107424 0.506433
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.00173822 0.0956339 0.0950719
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0130955 1 1
Entamoeba histolytica P-glyco protein 6, putative 0.00173822 0.0956339 0.450526
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.00188629 0.107424 0.10687
Entamoeba histolytica cysteine protease, putative 0.000995025 0.036454 0.16991
Trichomonas vaginalis abcb9, putative 0.00173822 0.0956339 0.149383
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.00173043 0.0950129 0.0944505
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.000995025 0.036454 0.16991
Brugia malayi Papain family cysteine protease containing protein 0.000995025 0.036454 0.0085019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.00319348 0.211514 0.441889
Schistosoma mansoni multidrug resistance protein 0.00173822 0.0956339 0.0950719

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.5 uM Antitrypanosomal activity against Trypanosoma brucei ChEMBL. 18420405
EC50 (functional) = 1.5 uM Antitrypanosomal activity against Trypanosoma brucei ChEMBL. 18420405
EC50 (functional) = 30 uM Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 infected human O+ erythrocytes by DNA stain with pepstatin ChEMBL. 19447616
EC50 (functional) > 30 uM Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 infected human O+ erythrocytes by DNA stain without pepstatin ChEMBL. 19447616
IC50 (binding) = 0.008 uM Inhibition of Trypanosoma brucei rhodesain ChEMBL. 18420405
IC50 (binding) = 0.0094 uM Inhibition of human cathepsin L ChEMBL. 18420405
IC50 (binding) = 0.0094 uM Inhibition of human cathepsin L ChEMBL. 18420405
IC50 (binding) = 0.21 uM Inhibition of Trypanosoma brucei cathepsin B ChEMBL. 18420405
IC50 (binding) = 0.21 uM Inhibition of human cathepsin B ChEMBL. 18420405
IC50 (binding) = 0.21 uM Inhibition of human cathepsin B ChEMBL. 18420405
Ratio EC50 (functional) > 17 Therapeutic index, ratio of EC50 for human Raji cells to EC50 for Trypanosoma brucei ChEMBL. 18420405

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Trypanosoma brucei gambiense 18420405
Trypanosoma brucei ChEMBL23 18420405

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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