Detailed information for compound 513321

Basic information

Technical information
  • TDR Targets ID: 513321
  • Name: 2-[(4-hydroxy-3,5-dimethylphenyl)methylidene] cyclopent-4-ene-1,3-dione
  • MW: 228.243 | Formula: C14H12O3
  • H donors: 1 H acceptors: 3 LogP: 2.46 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C=CC(=O)/C/1=C\c1cc(C)c(c(c1)C)O
  • InChi: 1S/C14H12O3/c1-8-5-10(6-9(2)14(8)17)7-11-12(15)3-4-13(11)16/h3-7,17H,1-2H3
  • InChiKey: YHWRISYBKMXSGJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(4-hydroxy-3,5-dimethyl-phenyl)methylene]cyclopent-4-ene-1,3-dione
  • 2-[(4-hydroxy-3,5-dimethylphenyl)methylene]cyclopent-4-ene-1,3-dione
  • 2-[(4-hydroxy-3,5-dimethyl-phenyl)methylidene]cyclopent-4-ene-1,3-dione
  • 2-(4-hydroxy-3,5-dimethyl-benzylidene)cyclopent-4-ene-1,3-quinone
  • 2-((3,5-dimethyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione
  • TX-1918
  • K00011
  • TX-1918; 2-((3,5-dimethyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens eukaryotic elongation factor 2 kinase-like Starlite/ChEMBL References
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni eukaryotic elongation factor 2 kinase (eef-2 kinase) Get druggable targets OG5_130980 All targets in OG5_130980
Leishmania donovani myosin heavy chain kinase a-like protein Get druggable targets OG5_130980 All targets in OG5_130980
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis eukaryotic elongation factor 2 kinase Get druggable targets OG5_130980 All targets in OG5_130980
Brugia malayi MHCK/EF2 kinase domain family protein Get druggable targets OG5_130980 All targets in OG5_130980
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania major myosin heavy chain kinase a-like protein Get druggable targets OG5_130980 All targets in OG5_130980
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Elongation factor 2 kinase, putative Get druggable targets OG5_130980 All targets in OG5_130980
Schistosoma japonicum expressed protein Get druggable targets OG5_130980 All targets in OG5_130980
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania infantum myosin heavy chain kinase a-like protein Get druggable targets OG5_130980 All targets in OG5_130980
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania braziliensis myosin heavy chain kinase a-like protein Get druggable targets OG5_130980 All targets in OG5_130980
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma cruzi myosin heavy chain kinase A, putative Get druggable targets OG5_130980 All targets in OG5_130980
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus eukaryotic elongation factor 2 kinase Get druggable targets OG5_130980 All targets in OG5_130980
Trypanosoma congolense myosin heavy chain kinase A, putative Get druggable targets OG5_130980 All targets in OG5_130980
Trypanosoma brucei gambiense myosin heavy chain kinase A, putative Get druggable targets OG5_130980 All targets in OG5_130980
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei myosin heavy chain kinase A, putative Get druggable targets OG5_130980 All targets in OG5_130980
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma congolense myosin heavy chain kinase A, putative Get druggable targets OG5_130980 All targets in OG5_130980
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei gambiense myosin heavy chain kinase A, putative Get druggable targets OG5_130980 All targets in OG5_130980
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma cruzi myosin heavy chain kinase A, putative Get druggable targets OG5_130980 All targets in OG5_130980
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei myosin heavy chain kinase A, putative Get druggable targets OG5_130980 All targets in OG5_130980
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08292 elongation factor 2 kinase [EC2.7.11.20], putative Get druggable targets OG5_130980 All targets in OG5_130980
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130980 All targets in OG5_130980
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma congolense myosin heavy chain kinase A, putative Get druggable targets OG5_130980 All targets in OG5_130980
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania mexicana myosin heavy chain kinase a-like protein Get druggable targets OG5_130980 All targets in OG5_130980
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0211 0.1311 0.1311
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.1878 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0014 0.0026
Echinococcus multilocularis eukaryotic elongation factor 2 kinase 0.0038 0.0178 0.0342
Loa Loa (eye worm) hypothetical protein 0.0084 0.0476 0.0476
Schistosoma mansoni lamin 0.0027 0.0107 0.0607
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0107 0.0107
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0085 0.0452
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0279 0.1757 1
Trypanosoma cruzi aminopeptidase, putative 0.0059 0.0316 0.8239
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0038 0.0219
Brugia malayi Carboxylesterase family protein 0.0066 0.0361 0.0361
Leishmania major myosin heavy chain kinase a-like protein 0.0038 0.0178 0.4851
Brugia malayi intermediate filament protein 0.0027 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0045 0.0225 0.0225
Brugia malayi hypothetical protein 0.0037 0.0167 0.0167
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0182
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0046 0.023 0.0441
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0085 0.0085
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0367 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0085 0.0085
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0367 0.0367
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0037 0.0167 0.0891
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0068 0.0373 0.212
Onchocerca volvulus 0.0064 0.0348 0.0787
Loa Loa (eye worm) hypothetical protein 0.0279 0.1757 0.1757
Brugia malayi ephrin receptor 1 precursor 0.0032 0.0138 0.0138
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0167 0.4555
Brugia malayi Peptidase family M1 containing protein 0.0059 0.0316 0.0316
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0059 0.0316 0.1682
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0037 0.0167 0.8586
Loa Loa (eye worm) hypothetical protein 0.0037 0.0167 0.0167
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0042 0.0201 0.0294
Loa Loa (eye worm) hypothetical protein 0.0018 0.0045 0.0045
Loa Loa (eye worm) peptidase family M13 containing protein 0.0206 0.128 0.128
Loa Loa (eye worm) hypothetical protein 0.0038 0.0178 0.0178
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0059 0.0316 0.8239
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.1533 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0705 0.0705
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0046 0.023 0.0441
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0361 0.2053
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.023 0.0441
Loa Loa (eye worm) hypothetical protein 0.0064 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0206 0.128 0.128
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0182 0.0266
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0046 0.023 0.0336
Schistosoma mansoni ephrin receptor 0.0066 0.0361 0.2052
Schistosoma mansoni tyrosine kinase 0.0046 0.023 0.1309
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0085 0.2311
Loa Loa (eye worm) hypothetical protein 0.0211 0.1311 0.1311
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0188 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.0037 0.0171 0.0328
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0046 0.023 0.0441
Loa Loa (eye worm) hypothetical protein 0.0024 0.0085 0.0085
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0032 0.0032
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0367 1
Brugia malayi Peptidase family M13 containing protein 0.0279 0.1757 0.1757
Brugia malayi hypothetical protein 0.0211 0.1313 0.1313
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0059 0.0316 0.8599
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0023 0.0023
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0211 0.0309
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.023 0.0336
Brugia malayi peptidase family M13 containing protein 0.0068 0.0373 0.0373
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0073 0.0404 0.2301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.1878 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.1878 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0546 0.0798
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0546 0.3106
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0259 0.0259
Onchocerca volvulus 0.0059 0.0316 0.0715
Schistosoma mansoni neprilysin-2 (M13 family) 0.0141 0.085 0.4839
Loa Loa (eye worm) hypothetical protein 0.0211 0.1311 0.1311
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0167 0.0245
Onchocerca volvulus 0.0138 0.0834 0.1886
Echinococcus granulosus tyrosine protein kinase HCK 0.0037 0.0171 0.025
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0023 0.0023
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0188 0.0275
Brugia malayi TATA binding protein associated factor 0.0037 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0018 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0073 0.0404 0.2301
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0059 0.0316 0.0462
Echinococcus multilocularis endothelin converting enzyme 1 0.0279 0.1757 0.3372
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0259 0.0259
Echinococcus multilocularis aminopeptidase N 0.0143 0.0865 0.166
Schistosoma mansoni tyrosine kinase 0.0046 0.023 0.1309
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0037 0.0167 0.0952
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0188 0.0998
Onchocerca volvulus 0.0055 0.0287 0.065
Trypanosoma cruzi aminopeptidase, putative 0.0037 0.0167 0.3154
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0046 0.023 0.0336
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0367 0.209
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.023 0.0441
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0037 0.0167 0.3154
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0068 0.0373 0.212
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0059 0.0316 0.8599
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0361 0.0692
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0182
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0055 0.0287 0.065
Onchocerca volvulus 0.0024 0.0085 0.0192
Brugia malayi Peptidase family M1 containing protein 0.0143 0.0865 0.0865
Echinococcus granulosus intermediate filament protein 0.0027 0.0107 0.0156
Echinococcus granulosus tyrosine protein kinase Lyn 0.0046 0.023 0.0336
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.0894 0.5089
Loa Loa (eye worm) acetyltransferase 0.0147 0.0894 0.0894
Echinococcus granulosus ephrin type A receptor 4 A 0.0066 0.0361 0.0527
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0367 0.0367
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.1878 1
Loa Loa (eye worm) zinc metallopeptidase 4 0.0068 0.0373 0.0373
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0206 0.128 0.128
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.1878 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0045 0.0256
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0059 0.0316 0.1682
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0037 0.0167 0.8586
Schistosoma mansoni hypothetical protein 0.0073 0.0404 0.2301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.1878 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0032 0.0061
Loa Loa (eye worm) hypothetical protein 0.0051 0.0259 0.0259
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0085 0.0452
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0046 0.023 0.0441
Trypanosoma cruzi myosin heavy chain kinase A, putative 0.0038 0.0178 0.3526
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.1878 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0037 0.0167 0.7362
Mycobacterium ulcerans hypothetical protein 0.0024 0.0085 0.0483
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0141 0.085 0.4839
Echinococcus multilocularis lamin dm0 0.0027 0.0107 0.0205
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0085 0.0483
Loa Loa (eye worm) hypothetical protein 0.0037 0.0167 0.0167
Echinococcus multilocularis geminin 0.0172 0.1058 0.203
Echinococcus granulosus Solute carrier family 22 5 0.1052 0.6838 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.012 0.0717 0.0717
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0211 0.0276
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.023 0.0336
Echinococcus multilocularis tyrosine protein kinase Srms 0.0042 0.0201 0.0385
Schistosoma mansoni neprilysin 0.0073 0.0404 0.2301
Onchocerca volvulus 0.0143 0.0865 0.1958
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0032 0.0032
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0361 0.0528
Schistosoma mansoni hypothetical protein 0.0073 0.0404 0.2301
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0059 0.0316 0.1798
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0367 0.0537
Schistosoma mansoni hypothetical protein 0.0073 0.0404 0.2301
Loa Loa (eye worm) hypothetical protein 0.0274 0.1726 0.1726
Treponema pallidum fructose-bisphosphate aldolase 0.0297 0.1878 0.5
Echinococcus granulosus GPCR family 2 0.0016 0.0032 0.0047
Loa Loa (eye worm) hypothetical protein 0.0206 0.128 0.128
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0032 0.0032
Trypanosoma brucei myosin heavy chain kinase A, putative 0.0038 0.0178 0.0544
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0867 0.1268
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0037 0.0167 0.4555
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0023 0.0075 0.0428
Onchocerca volvulus 0.0027 0.0107 0.0241
Loa Loa (eye worm) hypothetical protein 0.0206 0.128 0.128
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0085 0.2311
Echinococcus granulosus leukotriene A 4 hydrolase 0.0248 0.1553 0.2272
Onchocerca volvulus 0.0027 0.0107 0.0241
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0085 0.0483
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.088 0.5007
Echinococcus multilocularis lamin 0.0027 0.0107 0.0205
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0248 0.1553 0.1553
Echinococcus multilocularis tyrosine protein kinase Blk 0.0042 0.0201 0.0385
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.5212 1
Schistosoma mansoni hypothetical protein 0.0073 0.0404 0.2301
Trypanosoma cruzi myosin heavy chain kinase A, putative 0.0038 0.0178 0.3526
Loa Loa (eye worm) hypothetical protein 0.0024 0.0085 0.0085
Schistosoma mansoni hypothetical protein 0.0073 0.0404 0.2301
Brugia malayi MHCK/EF2 kinase domain family protein 0.0038 0.0178 0.0178
Brugia malayi protein-tyrosine kinase 0.0042 0.0201 0.0201
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0182
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0059 0.0316 0.0606
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0046 0.023 0.0441
Loa Loa (eye worm) hypothetical protein 0.0035 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0018 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0211 0.1311 0.1311
Loa Loa (eye worm) hypothetical protein 0.0018 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0018 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0037 0.0167 0.0167
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.088 0.4753
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0068 0.0373 0.212
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0085 0.0483
Loa Loa (eye worm) hypothetical protein 0.0279 0.1757 0.1757
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0141 0.085 0.4839
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0367 0.1956
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0367 0.0705
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0085 0.0483
Mycobacterium ulcerans zinc metalloprotease 0.0279 0.1757 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0042 0.0201 0.0294
Loa Loa (eye worm) TK protein kinase 0.0042 0.0201 0.0201
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0059 0.0316 0.7428
Echinococcus granulosus tyrosine protein kinase Src64B 0.0046 0.023 0.0336
Toxoplasma gondii peptidase family M13 protein 0.0279 0.1757 1
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0248 0.1553 0.8839
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.088 0.5007
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0032 0.0061
Echinococcus granulosus acetylcholinesterase 0.0066 0.0361 0.0528
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0085 0.0452
Entamoeba histolytica aminopeptidase, putative 0.0059 0.0316 0.1682
Loa Loa (eye worm) hypothetical protein 0.0066 0.0361 0.0361
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.1878 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0059 0.0316 0.0606
Loa Loa (eye worm) hypothetical protein 0.0013 0.0014 0.0014
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0085 0.0483
Echinococcus granulosus eukaryotic elongation factor 2 kinase 0.0038 0.0178 0.0261
Onchocerca volvulus Phospholipase A2 homolog 0.0684 0.4419 1
Loa Loa (eye worm) hypothetical protein 0.0684 0.4419 0.4419
Schistosoma mansoni eukaryotic elongation factor 2 kinase (eef-2 kinase) 0.0038 0.0178 0.1014
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0211 0.1125
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0182 0.0349
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0141 0.085 0.4839
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0032 0.0047
Schistosoma mansoni lamin 0.0027 0.0107 0.0607
Echinococcus granulosus lamin dm0 0.0027 0.0107 0.0156
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0059 0.0316 0.0606
Trypanosoma brucei myosin heavy chain kinase A, putative 0.0038 0.0178 0.0544
Mycobacterium ulcerans aminopeptidase N PepN 0.0059 0.0316 0.1798
Loa Loa (eye worm) TK/EPH protein kinase 0.0084 0.0476 0.0476
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0188 0.036
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0059 0.0316 0.0606
Loa Loa (eye worm) hypothetical protein 0.0033 0.0141 0.0141
Loa Loa (eye worm) peptidase family M13 containing protein 0.0206 0.128 0.128
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0038 0.0219
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0059 0.0316 0.0462
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0279 0.1757 0.1757
Brugia malayi hypothetical protein 0.0059 0.0316 0.0316
Echinococcus multilocularis musashi 0.0027 0.0107 0.0205
Echinococcus granulosus geminin 0.0172 0.1058 0.1547
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.0894 0.1716
Loa Loa (eye worm) hypothetical protein 0.0138 0.0834 0.0834
Loa Loa (eye worm) TK protein kinase 0.0037 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0027 0.0103 0.0103
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0279 0.1757 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0085 0.0085
Echinococcus granulosus endothelin converting enzyme 1 0.0279 0.1757 0.257
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0085 0.0483
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0141 0.085 0.4839
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0059 0.0316 0.0606
Trypanosoma brucei Aminopeptidase M1, putative 0.0059 0.0316 0.7428
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0546 0.0798
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0201 0.0385
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0037 0.0167 0.0245
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.1878 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0059 0.0316 0.0462
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0367 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0107 0.0107
Schistosoma mansoni hypothetical protein 0.0016 0.0032 0.0182
Loa Loa (eye worm) carboxylesterase 0.0066 0.0361 0.0361
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0045 0.0256
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0367 1
Onchocerca volvulus 0.0055 0.0287 0.065
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0037 0.0167 0.3154
Schistosoma mansoni intermediate filament proteins 0.0027 0.0107 0.0607
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0211 0.1125
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0032 0.0047
Brugia malayi SRC-1 0.0046 0.023 0.023
Schistosoma mansoni aminopeptidase A (M01 family) 0.0037 0.0167 0.0952
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0259 0.0259
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0546 0.3106
Loa Loa (eye worm) SRC-1 0.0046 0.023 0.023
Trypanosoma cruzi Aminopeptidase M1, putative 0.0059 0.0316 0.8239
Loa Loa (eye worm) hypothetical protein 0.0024 0.0085 0.0085
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0046 0.023 0.0441
Brugia malayi Peptidase family M1 containing protein 0.0037 0.0167 0.0167
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0037 0.0167 0.3154
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0085 0.0483
Echinococcus multilocularis ephrin type A receptor 4 A 0.0066 0.0361 0.0692
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0211 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0075
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0546 0.0546
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0546 0.1047
Loa Loa (eye worm) hypothetical protein 0.0211 0.1311 0.1311
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0037 0.0167 0.3154
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0085 0.2311
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0085 0.0483
Loa Loa (eye worm) TATA binding protein associated factor 0.0037 0.0167 0.0167
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0059 0.0316 0.1798
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0546 0.0546
Echinococcus granulosus tyrosine protein kinase Src42A 0.0046 0.023 0.0336
Loa Loa (eye worm) hypothetical protein 0.0066 0.0361 0.0361
Entamoeba histolytica protein kinase, putative 0.0016 0.0029 0.0155
Entamoeba histolytica protein kinase, putative 0.0037 0.0171 0.0911
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0023 0.0075 0.0144
Schistosoma mansoni hypothetical protein 0.0172 0.1058 0.602
Loa Loa (eye worm) hypothetical protein 0.0106 0.0624 0.0624
Brugia malayi MH2 domain containing protein 0.0118 0.0705 0.0705
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0107 0.0107
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.1878 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0248 0.1553 0.298
Schistosoma mansoni hypothetical protein 0.0172 0.1058 0.602
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0361 0.0692
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0107 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0546 0.3106
Loa Loa (eye worm) hypothetical protein 0.0279 0.1757 0.1757
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0211 0.1311 0.1311
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0068 0.0373 0.212
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0705 0.0705
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0075
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0037 0.0167 0.7362
Brugia malayi Carboxylesterase family protein 0.0066 0.0361 0.0361
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0038 0.0219
Schistosoma mansoni endothelin-converting enzyme-related 0.0068 0.0373 0.212
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0211 0.0276
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0361 0.0692
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0014 0.002
Loa Loa (eye worm) aminopeptidase N 0.0059 0.0316 0.0316
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0059 0.0316 0.0606
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0085 0.0483
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0055 0.0287 0.042
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0055 0.0287 0.1634
Mycobacterium leprae probable zinc metalloprotease 0.0279 0.1757 1
Onchocerca volvulus 0.0055 0.0287 0.065
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0038 0.0219
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.0894 0.0894
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0059 0.0316 0.0462
Echinococcus granulosus aminopeptidase N 0.0143 0.0865 0.1265
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0068 0.0373 0.212
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0032 0.0061
Echinococcus granulosus tyrosine kinase 0.0042 0.0201 0.0294
Onchocerca volvulus 0.0037 0.0167 0.0379
Trypanosoma brucei Aminopeptidase M1, putative 0.0059 0.0316 0.7428
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0045 0.5
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.1878 1
Onchocerca volvulus Phospholipase A2 homolog 0.0274 0.1726 0.3905
Mycobacterium ulcerans aminopeptidase N PepN 0.0037 0.0167 0.0952
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0055 0.0287 0.0551
Onchocerca volvulus 0.0055 0.0287 0.065
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.023 0.0336
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0546 0.1047
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Brugia malayi Phospholipase A2 family protein 0.0684 0.4419 0.4419
Echinococcus granulosus acetylcholinesterase 0.0066 0.0361 0.0528
Schistosoma mansoni hypothetical protein 0.0035 0.0154 0.0877
Echinococcus granulosus lamin 0.0027 0.0107 0.0156
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.023 0.0441

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 2070 nM Antitumor activity against human HepG2 cells ChEMBL. 18077363
EC50 (functional) = 2070 nM Antitumor activity against human HepG2 cells ChEMBL. 18077363
EC50 (functional) = 230000 nM Antitumor activity against human HCT116 cells ChEMBL. 18077363
EC50 (functional) = 230000 nM Antitumor activity against human HCT116 cells ChEMBL. 18077363
IC50 (binding) = 440 nM Inhibition of eEF2 kinase (unknown origin) ChEMBL. 18077363
IC50 (binding) = 440 nM Inhibition of eEF2 kinase (unknown origin) ChEMBL. 18077363
IC50 (binding) = 4400 nM Inhibition of Src (unknown origin) ChEMBL. 18077363
IC50 (binding) = 4400 nM Inhibition of Src (unknown origin) ChEMBL. 18077363
IC50 (binding) = 44000 nM Inhibition of PKA (unknown origin) ChEMBL. 18077363
IC50 (binding) = 44000 nM Inhibition of PKC (unknown origin) ChEMBL. 18077363
IC50 (binding) = 440000 nM Inhibition of EGFR (unknown origin) ChEMBL. 18077363
IC50 (binding) = 440000 nM Inhibition of EGFR (unknown origin) ChEMBL. 18077363
Thermal melting change (binding) = -7.9 degrees C Delta TM value showing the stabilisation of RSK2b produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -7.1 degrees C Delta TM value showing the stabilisation of JAK1~B produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -5.7 degrees C Delta TM value showing the stabilisation of PIM2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -4.6 degrees C Delta TM value showing the stabilisation of DRAK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -4.1 degrees C Delta TM value showing the stabilisation of TNIK produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -3.4 degrees C Delta TM value showing the stabilisation of CDK6 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -3.1 degrees C Delta TM value showing the stabilisation of VRK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -2.9 degrees C Delta TM value showing the stabilisation of GSK3B produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -2.6 degrees C Delta TM value showing the stabilisation of PAK6 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -2.2 degrees C Delta TM value showing the stabilisation of AMPKA2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -2.2 degrees C Delta TM value showing the stabilisation of CDKL1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -2 degrees C Delta TM value showing the stabilisation of MEK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -1.6 degrees C Delta TM value showing the stabilisation of ERK3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -1.5 degrees C Delta TM value showing the stabilisation of CLK3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -1.4 degrees C Delta TM value showing the stabilisation of CAMKK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -1.4 degrees C Delta TM value showing the stabilisation of PIM1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -1 degrees C Delta TM value showing the stabilisation of CAMK1D produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.8 degrees C Delta TM value showing the stabilisation of CLK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.4 degrees C Delta TM value showing the stabilisation of CAMK1G produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.4 degrees C Delta TM value showing the stabilisation of CLK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.4 degrees C Delta TM value showing the stabilisation of NEK6 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.4 degrees C Delta TM value showing the stabilisation of PDK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.3 degrees C Delta TM value showing the stabilisation of VRK3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.1 degrees C Delta TM value showing the stabilisation of CAMK2B produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.1 degrees C Delta TM value showing the stabilisation of CAMK4 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.1 degrees C Delta TM value showing the stabilisation of CK1G3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.1 degrees C Delta TM value showing the stabilisation of MST4 (2) produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.1 degrees C Delta TM value showing the stabilisation of CK1G1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.1 degrees C Delta TM value showing the stabilisation of OSR1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.1 degrees C Delta TM value showing the stabilisation of PAK5 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.2 degrees C Delta TM value showing the stabilisation of NDR1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.2 degrees C Delta TM value showing the stabilisation of PBK produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.2 degrees C Delta TM value showing the stabilisation of VRK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.3 degrees C Delta TM value showing the stabilisation of CAMK2G produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.3 degrees C Delta TM value showing the stabilisation of DMPK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.4 degrees C Delta TM value showing the stabilisation of MST4(1) produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.4 degrees C Delta TM value showing the stabilisation of YSK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.5 degrees C Delta TM value showing the stabilisation of CK1G2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.5 degrees C Delta TM value showing the stabilisation of PRKACA produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.6 degrees C Delta TM value showing the stabilisation of DAPK3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.6 degrees C Delta TM value showing the stabilisation of ERK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.6 degrees C Delta TM value showing the stabilisation of PLK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.7 degrees C Delta TM value showing the stabilisation of PAK4 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.7 degrees C Delta TM value showing the stabilisation of RIOK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.7 degrees C Delta TM value showing the stabilisation of SLK produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.8 degrees C Delta TM value showing the stabilisation of NEK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.8 degrees C Delta TM value showing the stabilisation of MST1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1 degrees C Delta TM value showing the stabilisation of CDK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.1 degrees C Delta TM value showing the stabilisation of CAMK2D produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.2 degrees C Delta TM value showing the stabilisation of CAMK2A produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.2 degrees C Delta TM value showing the stabilisation of LOK produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.3 degrees C Delta TM value showing the stabilisation of PLK4 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.8 degrees C Delta TM value showing the stabilisation of RSK2a produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 2.2 degrees C Delta TM value showing the stabilisation of PCTK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 2.3 degrees C Delta TM value showing the stabilisation of p38beta produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 2.5 degrees C Delta TM value showing the stabilisation of CHEK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 2.6 degrees C Delta TM value showing the stabilisation of ASK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 3.2 degrees C Delta TM value showing the stabilisation of MPSK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 3.6 degrees C Delta TM value showing the stabilisation of PIM3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 7.9 degrees C Delta TM value showing the stabilisation of MAP2K6 produced by compound binding ChEMBL. 18077363

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 18077363

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.