Detailed information for compound 53063

Basic information

Technical information
  • TDR Targets ID: 53063
  • Name: (2S,5S,6R,11R)-11-benzyl-6-heptyl-5,12-dimeth yl-2-propan-2-yl-3,7-dioxa-12-azacyclododecan e-1,4,8-trione
  • MW: 473.645 | Formula: C28H43NO5
  • H donors: 0 H acceptors: 3 LogP: 6.98 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCC[C@H]1OC(=O)CC[C@H](Cc2ccccc2)N(C(=O)[C@@H](OC(=O)[C@H]1C)C(C)C)C
  • InChi: 1S/C28H43NO5/c1-6-7-8-9-13-16-24-21(4)28(32)34-26(20(2)3)27(31)29(5)23(17-18-25(30)33-24)19-22-14-11-10-12-15-22/h10-12,14-15,20-21,23-24,26H,6-9,13,16-19H2,1-5H3/t21-,23+,24+,26-/m0/s1
  • InChiKey: VHUIPQJPOUPXDB-PFHLPCBSSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S,5S,6R,11R)-11-benzyl-6-heptyl-2-isopropyl-5,12-dimethyl-3,7-dioxa-12-azacyclododecane-1,4,8-trione
  • (2S,5S,6R,11R)-6-heptyl-5,12-dimethyl-11-(phenylmethyl)-2-propan-2-yl-3,7-dioxa-12-azacyclododecane-1,4,8-trione
  • (2S,5R,10R,11S)-10-heptyl-4,11-dimethyl-5-(phenylmethyl)-2-propan-2-yl-1,9-dioxa-4-azacyclododecane-3,8,12-trione
  • (2S,5R,10R,11S)-10-heptyl-2-isopropyl-4,11-dimethyl-5-(phenylmethyl)-1,9-dioxa-4-azacyclododecane-3,8,12-trione
  • (2S,5R,10R,11S)-5-(benzyl)-10-heptyl-2-isopropyl-4,11-dimethyl-1,9-dioxa-4-azacyclododecane-3,8,12-trione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi peter pan protein, putative 0.006 0.044 0.0385
Echinococcus multilocularis neuropeptide s receptor 0.0057 0.041 0.1124
Echinococcus granulosus expressed protein 0.0361 0.3648 1
Schistosoma mansoni opsin-like receptor 0.0057 0.041 0.0589
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0174 0.0389
Onchocerca volvulus 0.0057 0.041 0.0503
Schistosoma mansoni adenoreceptor 0.0057 0.041 0.0589
Brugia malayi Tachykinin-like peptides receptor 99D 0.0057 0.041 0.0914
Brugia malayi Fli-1 protein 0.0223 0.2183 0.4865
Echinococcus granulosus dro:myosuppressin receptor 0.0057 0.041 0.1124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0277 0.0397
Schistosoma mansoni gabp alpha 0.0074 0.0583 0.0837
Entamoeba histolytica hypothetical protein 0.0047 0.0296 0.4583
Loa Loa (eye worm) hypothetical protein 0.0063 0.0469 0.1045
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0312 0.3127 1
Echinococcus multilocularis fmrfamide receptor 0.0057 0.041 0.1124
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.041 0.1124
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.041 0.1124
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Schistosoma mansoni hypothetical protein 0.0057 0.041 0.0589
Loa Loa (eye worm) hypothetical protein 0.0324 0.3261 0.7267
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.041 0.0589
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0057 0.041 0.0914
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.041 0.1124
Brugia malayi PAS domain containing protein 0.0048 0.0307 0.0684
Trypanosoma brucei hypothetical protein, conserved 0.0081 0.0659 0.0605
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0021 0.002 0.0029
Schistosoma mansoni histamine h1 receptor 0.0057 0.041 0.0589
Brugia malayi Pre-SET motif family protein 0.006 0.0435 0.097
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.041 0.0914
Echinococcus granulosus 7tm_1 domain containing protein 0.0057 0.041 0.1124
Echinococcus granulosus biogenic amine 5HT receptor 0.0057 0.041 0.1124
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0174 0.0477
Brugia malayi RNase H family protein 0.0066 0.0497 0.1107
Brugia malayi neuropeptide F receptor 0.0057 0.041 0.0914
Echinococcus multilocularis g protein coupled receptor 0.0057 0.041 0.1124
Brugia malayi AKH receptor 0.0057 0.041 0.0914
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.041 0.1124
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0307 0.0441
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0452 0.4626 0.4595
Onchocerca volvulus 0.0047 0.0296 0.0259
Plasmodium vivax SET domain protein, putative 0.006 0.0435 0.0544
Onchocerca volvulus 0.0057 0.041 0.0503
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.041 0.0914
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.041 0.1124
Echinococcus granulosus g-protein coupled receptor 0.0057 0.041 0.1124
Echinococcus multilocularis neuropeptide FF receptor 2 0.0057 0.041 0.1124
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0056 0.0393 0.0565
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0435 0.1193
Brugia malayi hypothetical protein 0.0057 0.041 0.0914
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Brugia malayi DNA polymerase alpha catalytic subunit 0.0045 0.0281 0.0625
Brugia malayi Brix domain containing protein 0.006 0.044 0.098
Leishmania major peter pan protein, putative 0.006 0.044 0.0385
Echinococcus multilocularis ribonuclease H1 0.0066 0.0497 0.1362
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.041 0.0589
Echinococcus granulosus fmrfamide receptor 0.0057 0.041 0.1124
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0057 0.041 0.1124
Mycobacterium tuberculosis Conserved hypothetical protein 0.0503 0.5171 1
Schistosoma mansoni DNA polymerase gamma 0.0101 0.0873 0.1253
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0417 0.4247 0.9465
Brugia malayi RNase H family protein 0.0066 0.0497 0.1107
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Schistosoma mansoni biogenic amine receptor 0.0057 0.041 0.0589
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0516 0.0741
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0452 0.4626 0.4595
Echinococcus multilocularis neuropeptide receptor 0.0057 0.041 0.1124
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0312 0.3127 0.5908
Schistosoma mansoni opsin-like receptor 0.0057 0.041 0.0589
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.041 0.1124
Onchocerca volvulus Peter pan protein homolog 0.006 0.044 0.0566
Schistosoma mansoni hypothetical protein 0.0051 0.0342 0.0491
Loa Loa (eye worm) replication-associated protein 0.0047 0.0296 0.0659
Brugia malayi hypoxia-induced factor 1 0.0148 0.1376 0.3065
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0077 0.0617 0.0943
Schistosoma mansoni peter pan-related 0.006 0.044 0.0632
Loa Loa (eye worm) brix domain-containing protein 0.006 0.044 0.098
Brugia malayi ORL1-like opioid receptor 0.0057 0.041 0.0914
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.041 0.1124
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.041 0.1124
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.041 0.1124
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.041 0.1124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0277 0.0397
Echinococcus granulosus neuropeptide receptor 0.0057 0.041 0.1124
Echinococcus granulosus neuropeptide s receptor 0.0057 0.041 0.1124
Onchocerca volvulus 0.0057 0.041 0.0503
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.041 0.0589
Treponema pallidum ribonuclease H (rnhA) 0.0066 0.0497 0.5
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0312 0.3127 0.5
Echinococcus granulosus serotonin receptor 0.0057 0.041 0.1124
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.041 0.1124
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Brugia malayi hypothetical protein 0.0057 0.041 0.0914
Echinococcus multilocularis serotonin receptor 0.0057 0.041 0.1124
Brugia malayi Ets-domain containing protein 0.0074 0.0583 0.1299
Echinococcus granulosus g protein coupled receptor 0.0057 0.041 0.1124
Loa Loa (eye worm) melatonin receptor type 1A 0.0057 0.041 0.0914
Brugia malayi DNA polymerase I family protein 0.0101 0.0873 0.1945
Echinococcus multilocularis g-protein coupled receptor 0.0057 0.041 0.1124
Onchocerca volvulus 0.0057 0.041 0.0503
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus multilocularis G protein coupled receptor 139 0.0057 0.041 0.1124
Echinococcus granulosus peptide allatostatin:somatostatin 0.0057 0.041 0.1124
Loa Loa (eye worm) hypothetical protein 0.016 0.1508 0.3361
Brugia malayi putative neuropeptide receptor NPR1 0.0057 0.041 0.0914
Onchocerca volvulus 0.0057 0.041 0.0503
Loa Loa (eye worm) fli-1 protein 0.0223 0.2183 0.4865
Brugia malayi hypothetical protein 0.0124 0.1126 0.251
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Trypanosoma cruzi ribonuclease H1, putative 0.0066 0.0497 0.0442
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0057 0.041 0.0914
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.041 0.1124
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0284 0.2833 0.6312
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0057 0.041 0.0589
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0057 0.041 0.0589
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0057 0.041 0.1124
Plasmodium vivax hypothetical protein, conserved 0.006 0.044 0.0559
Brugia malayi G-protein coupled receptor 0.0057 0.041 0.0914
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0174 0.0477
Brugia malayi putative neuropeptide receptor 0.0057 0.041 0.0914
Brugia malayi Ets-domain containing protein 0.0074 0.0583 0.1299
Onchocerca volvulus 0.0057 0.041 0.0503
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0101 0.0876 0.24
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0435 0.0625
Echinococcus multilocularis hypothetical protein 0.0101 0.0873 0.2393
Onchocerca volvulus 0.0057 0.041 0.0503
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0057 0.041 0.1124
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0057 0.041 0.0914
Trypanosoma brucei ingi protein (ORF1) 0.0081 0.0659 0.0605
Mycobacterium ulcerans hypothetical protein 0.0503 0.5171 1
Onchocerca volvulus 0.0057 0.041 0.0503
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Onchocerca volvulus 0.0057 0.041 0.0503
Echinococcus multilocularis g protein coupled receptor 0.0057 0.041 0.1124
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0057 0.041 0.0589
Trichomonas vaginalis set domain proteins, putative 0.0474 0.4862 1
Brugia malayi follicle stimulating hormone receptor 0.0284 0.2833 0.6312
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0057 0.041 0.0589
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0057 0.041 0.1124
Schistosoma mansoni single-minded 0.0048 0.0307 0.0441
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0312 0.3127 0.5908
Echinococcus multilocularis neuropeptide Y receptor 0.0057 0.041 0.1124
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0435 0.0625
Onchocerca volvulus 0.0057 0.041 0.0503
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0876 0.1257
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0081 0.0659 0.0605
Brugia malayi G-protein coupled receptor 0.0057 0.041 0.0914
Brugia malayi neuropeptide F receptor 0.0057 0.041 0.0914
Loa Loa (eye worm) hypothetical protein 0.0047 0.0296 0.0659
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.041 0.1124
Schistosoma mansoni amine GPCR 0.0057 0.041 0.0589
Leishmania major ribonuclease H1, putative 0.0066 0.0497 0.0442
Echinococcus multilocularis allatostatin A receptor 0.0057 0.041 0.1124
Echinococcus multilocularis serotonin receptor 0.0057 0.041 0.1124
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.041 0.0589
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0312 0.3127 1
Trichomonas vaginalis ssf, putative 0.006 0.044 0.0796
Brugia malayi hypothetical protein 0.0057 0.041 0.0914
Brugia malayi sulfakinin receptor protein 0.0057 0.041 0.0914
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Schistosoma mansoni amine GPCR 0.0057 0.041 0.0589
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Onchocerca volvulus 0.0057 0.041 0.0503
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.041 0.1124
Schistosoma mansoni hypothetical protein 0.0166 0.1574 0.226
Schistosoma mansoni hypothetical protein 0.0671 0.6964 1
Schistosoma mansoni phosphoglucomutase 0.0066 0.0497 0.0713
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0057 0.041 0.1124
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0312 0.3127 1
Schistosoma mansoni ets-related 0.0223 0.2183 0.3135
Loa Loa (eye worm) hypothetical protein 0.0101 0.0873 0.1945
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.041 0.0589
Brugia malayi Protein kinase domain containing protein 0.0439 0.4487 1
Echinococcus granulosus ribonuclease H1 0.0066 0.0497 0.1362
Schistosoma mansoni hypothetical protein 0.0057 0.041 0.0589
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0057 0.041 0.1124
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.041 0.1124
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0057 0.041 0.1124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0277 0.0397
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.041 0.1124
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.041 0.1124
Brugia malayi Dopamine receptor protein 1 0.0057 0.041 0.0914
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.041 0.1124
Toxoplasma gondii hypothetical protein 0.0154 0.1443 1
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.041 0.1124
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0277 0.0616
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0439 0.4487 1
Onchocerca volvulus 0.0057 0.041 0.0503
Trypanosoma brucei brix domain containing protein, putative 0.006 0.044 0.0385
Schistosoma mansoni phosphoglucomutase 0.0066 0.0497 0.0713
Schistosoma mansoni neuropeptide receptor 0.0057 0.041 0.0589
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus multilocularis peter pan 0.006 0.044 0.1206
Brugia malayi hypothetical protein 0.0035 0.0174 0.0388
Loa Loa (eye worm) hypothetical protein 0.0077 0.0617 0.1374
Onchocerca volvulus 0.0474 0.4862 1
Schistosoma mansoni neuropeptide receptor 0.0057 0.041 0.0589
Brugia malayi hypothetical protein 0.0057 0.041 0.0914
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0034 0.0076
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Schistosoma mansoni hypothetical protein 0.0057 0.041 0.0589
Echinococcus granulosus alpha 1A adrenergic receptor 0.0057 0.041 0.1124
Brugia malayi RNase H family protein 0.0066 0.0497 0.1107
Onchocerca volvulus 0.0047 0.0296 0.0259
Trichomonas vaginalis ribonuclease H1, putative 0.0066 0.0497 0.0915
Echinococcus granulosus g protein coupled receptor 0.0057 0.041 0.1124
Brugia malayi Probable ATP-dependent helicase DHX35 0.0033 0.0154 0.0344
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0955 1 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0516 0.1151
Brugia malayi Melibiase family protein 0.0067 0.0516 0.1151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.041 0.0589
Brugia malayi hypothetical protein 0.0057 0.041 0.0914
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.041 0.0589
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.041 0.0589
Echinococcus multilocularis zinc finger protein 598 0.006 0.0436 0.1195
Onchocerca volvulus Ribonuclease H1 homolog 0.0066 0.0497 0.0688
Brugia malayi Dopamine receptor 0.0057 0.041 0.0914
Onchocerca volvulus 0.0057 0.041 0.0503
Echinococcus multilocularis orexin receptor type 2 0.0057 0.041 0.1124
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0412 0.1129
Giardia lamblia Ribonuclease H 0.0066 0.0497 1
Loa Loa (eye worm) replication-associated protein 0.0047 0.0296 0.0659
Echinococcus granulosus peter pan 0.006 0.044 0.1206
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Loa Loa (eye worm) hypothetical protein 0.0033 0.0154 0.0344
Toxoplasma gondii ribonuclease HI protein 0.0066 0.0497 0.186
Echinococcus granulosus somatostatin receptor 0.0057 0.041 0.1124
Schistosoma mansoni opsin-like receptor 0.0057 0.041 0.0589
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.041 0.0589
Entamoeba histolytica hypothetical protein 0.0047 0.0296 0.4583
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0876 0.1257
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.041 0.0589
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0101 0.0876 0.24
Echinococcus granulosus hypothetical protein 0.0057 0.041 0.1124
Echinococcus granulosus neuropeptide FF receptor 2 0.0057 0.041 0.1124
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.0516 0.0955
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0134 0.1232 0.1181
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0229 0.2078
Echinococcus multilocularis g protein coupled receptor 0.0057 0.041 0.1124
Onchocerca volvulus Neuropeptide F receptor homolog 0.0057 0.041 0.0503
Echinococcus granulosus allatostatin A receptor 0.0057 0.041 0.1124
Echinococcus granulosus geminin 0.0166 0.1574 0.4313
Brugia malayi hypothetical protein 0.0057 0.041 0.0914
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0057 0.041 0.0914
Brugia malayi Pre-SET motif family protein 0.0417 0.4247 0.9465
Schistosoma mansoni growth hormone secretagogue receptor 0.0057 0.041 0.0589
Toxoplasma gondii melibiase subfamily protein 0.0101 0.0876 0.5121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0435 0.0625
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus multilocularis neuropeptide receptor 0.0057 0.041 0.1124
Onchocerca volvulus 0.0057 0.041 0.0503
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0277 0.0758
Toxoplasma gondii brix domain-containing protein 0.006 0.044 0.137
Trypanosoma cruzi ribonuclease H1, putative 0.0066 0.0497 0.0442
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.041 0.1124
Schistosoma mansoni hypothetical protein 0.0166 0.1574 0.226
Brugia malayi Dopamine receptor protein 2 0.0057 0.041 0.0914
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0101 0.0876 0.24
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.041 0.1124
Schistosoma mansoni peter pan-related 0.006 0.044 0.0632
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.041 0.1124
Echinococcus multilocularis fmrfamide receptor 0.0057 0.041 0.1124
Schistosoma mansoni neuropeptide f receptor 76f 0.0057 0.041 0.0589
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Onchocerca volvulus 0.0047 0.0296 0.0259
Brugia malayi GnHR receptor homolog 0.0057 0.041 0.0914
Brugia malayi G protein-coupled receptor F59B2.13 0.0057 0.041 0.0914
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0174 0.0478
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.041 0.0589
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus granulosus neuropeptide receptor 0.0057 0.041 0.1124
Brugia malayi hypothetical protein 0.0057 0.041 0.0914
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0057 0.041 0.0589
Schistosoma mansoni amine GPCR 0.0057 0.041 0.0589
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0057 0.041 0.1124
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus granulosus rhodopsin orphan GPCR 0.0057 0.041 0.1124
Echinococcus multilocularis G-protein coupled receptor, putative 0.0057 0.041 0.1124
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0435 0.1193
Echinococcus multilocularis neuropeptide receptor A26 0.0057 0.041 0.1124
Echinococcus multilocularis dro:myosuppressin receptor 0.0057 0.041 0.1124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.041 0.0589
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.1376 0.3065
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0516 0.0741
Echinococcus multilocularis sex peptide receptor 0.0057 0.041 0.1124
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0277 0.0616
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.041 0.0589
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0057 0.041 0.1124
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0229 0.2078
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0057 0.041 0.0914
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0134 0.1232 0.1181
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0057 0.041 0.0914
Schistosoma mansoni neuropeptide receptor 0.0057 0.041 0.0589
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus granulosus G protein coupled receptor 139 0.0057 0.041 0.1124
Onchocerca volvulus 0.0047 0.0296 0.0259
Brugia malayi Melatonin receptor type 1A 0.0057 0.041 0.0914
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.041 0.1124
Brugia malayi RE15519p 0.0057 0.041 0.0914
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0174 0.025
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0057 0.041 0.0589
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0876 0.1257
Echinococcus granulosus g protein coupled receptor 0.0057 0.041 0.1124
Echinococcus granulosus zinc finger protein 598 0.006 0.0436 0.1195
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Trypanosoma brucei ingi protein (ORF1) 0.0081 0.0659 0.0605
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Schistosoma mansoni amine GPCR 0.0057 0.041 0.0589
Entamoeba histolytica hypothetical protein 0.0047 0.0296 0.4583
Echinococcus granulosus tachykinin peptides receptor 99D 0.0057 0.041 0.1124
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0229 0.2078
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0312 0.3127 0.5908
Brugia malayi Serotonin receptor 0.0057 0.041 0.0914
Trypanosoma brucei unspecified product 0.0081 0.0659 0.0605
Echinococcus multilocularis expressed protein 0.0361 0.3648 1
Loa Loa (eye worm) neuropeptide F receptor 0.0057 0.041 0.0914
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0435 0.1193
Echinococcus granulosus neuropeptides capa receptor 0.0057 0.041 0.1124
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0229 0.2078
Echinococcus granulosus 7TM GPCR rhodopsin 0.0057 0.041 0.1124
Onchocerca volvulus 0.0057 0.041 0.0503
Trypanosoma brucei ribonuclease H1 0.0066 0.0497 0.0442
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0056 0.0393 0.1078
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0277 0.0758
Schistosoma mansoni alpha-1 adrenergic receptor 0.0057 0.041 0.0589
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0057 0.041 0.0589
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0056 0.0393 0.1078
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0583 0.1598
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0955 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0057 0.041 0.0589
Schistosoma mansoni phosphoglucomutase 0.0066 0.0497 0.0713
Schistosoma mansoni biogenic amine (5HT) receptor 0.0057 0.041 0.0589
Entamoeba histolytica fatty acid elongase, putative 0.004 0.0229 0.2078
Brugia malayi hypothetical protein 0.0057 0.041 0.0914
Loa Loa (eye worm) DEAH box polypeptide 35 0.0033 0.0154 0.0344
Echinococcus multilocularis rhodopsin orphan GPCR 0.0057 0.041 0.1124
Echinococcus multilocularis geminin 0.0166 0.1574 0.4313
Schistosoma mansoni biogenic amine receptor 0.0057 0.041 0.0589
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0057 0.041 0.0914
Echinococcus granulosus DNA polymerase subunit gamma 0.0101 0.0873 0.2393
Schistosoma mansoni myosin xvIII 0.0057 0.041 0.0589
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0277 0.0758
Echinococcus granulosus orexin receptor type 2 0.0057 0.041 0.1124
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0435 0.1331
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.041 0.1124
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0057 0.041 0.1124
Brugia malayi G protein-coupled receptor 0.0057 0.041 0.0914
Echinococcus multilocularis somatostatin receptor 0.0057 0.041 0.1124
Brugia malayi larval opioid receptor 0.0057 0.041 0.0914
Loa Loa (eye worm) replication-associated protein 0.0047 0.0296 0.0659
Schistosoma mansoni hypothetical protein 0.0035 0.0174 0.025
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0057 0.041 0.1124
Onchocerca volvulus 0.006 0.0435 0.0556
Schistosoma mansoni hypothetical protein 0.0057 0.041 0.0589
Schistosoma mansoni neuropeptide receptor 0.0057 0.041 0.0589
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0452 0.4626 0.4595
Entamoeba histolytica brix domain containing protein 0.006 0.044 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus granulosus neuropeptide receptor A26 0.0057 0.041 0.1124
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0057 0.041 0.0589
Giardia lamblia Peter pan protein 0.006 0.044 0.7081
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Loa Loa (eye worm) TYRA-2 protein 0.0057 0.041 0.0914
Schistosoma mansoni amine GPCR 0.0057 0.041 0.0589
Brugia malayi Serotonin receptor 0.0057 0.041 0.0914
Onchocerca volvulus 0.0057 0.041 0.0503
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0057 0.041 0.1124
Echinococcus granulosus sex peptide receptor 0.0057 0.041 0.1124
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0057 0.041 0.0503
Loa Loa (eye worm) G-protein coupled receptor 0.0057 0.041 0.0914
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0057 0.041 0.0914
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0435 0.0625
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0134 0.1232 0.1181
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0057 0.041 0.0914
Schistosoma mansoni neuropeptide F-like receptor 0.0057 0.041 0.0589
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0164 0.1545 0.1497
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0057 0.041 0.0589
Echinococcus granulosus single minded 2 0.0035 0.0174 0.0478
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0583 0.1299
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Trypanosoma brucei RNA helicase, putative 0.0671 0.6964 0.6947
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0057 0.041 0.1124
Schistosoma mansoni biogenic amine receptor 0.0057 0.041 0.0589
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0057 0.041 0.0589
Echinococcus granulosus neuropeptide Y receptor 0.0057 0.041 0.1124
Loa Loa (eye worm) hypothetical protein 0.006 0.0435 0.097
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0057 0.041 0.1124
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0876 0.1257
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus granulosus tm gpcr rhodopsin 0.0057 0.041 0.1124
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0955 1 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0583 0.1598
Onchocerca volvulus 0.0047 0.0296 0.0259
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0134 0.1232 0.1181
Brugia malayi Cytochrome P450 family protein 0.0022 0.0034 0.0076
Brugia malayi hypothetical protein 0.016 0.1508 0.3361
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Echinococcus multilocularis neuropeptides capa receptor 0.0057 0.041 0.1124
Onchocerca volvulus 0.0057 0.041 0.0503
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0277 0.0758
Brugia malayi hypothetical protein 0.0057 0.041 0.0914
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Loa Loa (eye worm) hypothetical protein 0.0057 0.041 0.0914
Trypanosoma cruzi peter pan protein, putative 0.006 0.044 0.0385
Brugia malayi hypothetical protein 0.0057 0.041 0.0914
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0057 0.041 0.1124
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0057 0.041 0.1124

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 6 uM Multidrug-resistant reversal activity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycoprotein) in the presence of 10 nM vincristine ChEMBL. 10386932
IC50 (functional) = 6 uM Multidrug-resistant reversal activity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycoprotein) in the presence of 10 nM vincristine ChEMBL. 10386932
IC50 (functional) = 33.7 uM Evaluated for cytotoxicity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycoprotein) in the absence of 10 nM vincristine ChEMBL. 10386932
IC50 (functional) = 33.7 uM Evaluated for cytotoxicity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycoprotein) in the absence of 10 nM vincristine ChEMBL. 10386932
Ratio (functional) = 5.6 Ratio of IC50 of cytotoxicity to the IC50 of MDR- reversal for P388/VMDRC.04 cells ChEMBL. 10386932

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.