Detailed information for compound 539961

Basic information

Technical information
  • TDR Targets ID: 539961
  • Name: N-[9-[(1S,6R,8R,9R)-3,9-dihydroxy-3-oxo-2,4,7 -trioxa-3$l^{5}-phosphabicyclo[4.3.0]nonan-8- yl]purin-6-yl]butanamide
  • MW: 399.296 | Formula: C14H18N5O7P
  • H donors: 3 H acceptors: 7 LogP: -1.87 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@H]2[C@H]([C@H]1O)OP(=O)(OC2)O
  • InChi: 1S/C14H18N5O7P/c1-2-3-8(20)18-12-9-13(16-5-15-12)19(6-17-9)14-10(21)11-7(25-14)4-24-27(22,23)26-11/h5-7,10-11,14,21H,2-4H2,1H3,(H,22,23)(H,15,16,18,20)/t7-,10-,11-,14-/m1/s1
  • InChiKey: NVGDLMUKSMHEQT-FRJWGUMJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[9-[(1S,6R,8R,9R)-3,9-dihydroxy-3-oxo-2,4,7-trioxa-3$l^{5}-phosphabicyclo[4.3.0]nonan-8-yl]-6-purinyl]butanamide
  • N-[9-[(1S,6R,8R,9R)-3,9-dihydroxy-3-keto-2,4,7-trioxa-3$l^{5}-phosphabicyclo[4.3.0]nonan-8-yl]purin-6-yl]butyramide
  • monobutyryl cyclic AMP
  • 13117-60-7
  • 29117-37-1
  • 32266-36-7
  • 33116-16-4
  • Adenosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate)
  • Cyclic N6-monobutyryl-AMP
  • Cyclic N6-monobutyryladenosine-3',5'-monophosphate
  • Monobutyryl adnosine cyclic 3',5'-monophosphate
  • N(6)-Butyryl adenosine-3',5'-cyclic monophosphate
  • N(6)-Butyryl cyclic AMP
  • N(6)-Monobutyryl adenosine-3',5'-cyclic monophosphate
  • N(6)-Monobutyryl cyclic AMP
  • N6-Butyryl-3',5'-cyclic AMP
  • N6-Butyryl-cAMP
  • N6-Butyryladenosine 3',5'-cyclic phosphate
  • N6-Monobutyryl-cAMP
  • N6-Monobutyryladenosine-3',5'-cyclic monophosphate
  • N6-Monobutyryladenosine-3',5'-cyclic monophosphoric acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1146 0.3191 1
Mycobacterium tuberculosis Conserved protein 0.0118 0.028 0.0732
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0046 0.011
Schistosoma mansoni pyruvate kinase 0.0037 0.0051 0.016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0011 0.0035
Loa Loa (eye worm) hypothetical protein 0.0263 0.069 0.2136
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0093 0.0135
Loa Loa (eye worm) hypothetical protein 0.0118 0.028 0.0846
Echinococcus multilocularis pyruvate kinase 0.0037 0.0051 0.0051
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0011 0.0011
Schistosoma mansoni glutathione synthetase 0.0395 0.1066 0.334
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.008 0.0174 0.0391
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0011 0.0035
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0118 0.028 0.0732
Echinococcus granulosus pyruvate kinase 0.0037 0.0051 0.016
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0141
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1146 0.3191 1
Mycobacterium tuberculosis Probable hydrolase 0.0118 0.028 0.0732
Echinococcus multilocularis geminin 0.034 0.0909 0.0909
Trypanosoma brucei hypothetical protein, conserved 0.0118 0.028 0.0729
Loa Loa (eye worm) hypothetical protein 0.0035 0.0046 0.011
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0039 0.0056 0.0019
Leishmania major polyprenyl synthase, putative 0.0566 0.155 0.4773
Schistosoma mansoni hypothetical protein 0.0035 0.0046 0.0145
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0016 0.0016
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0051 0.0126
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0092 0.0256
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0011 0.0035
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1146 0.3191 1
Plasmodium vivax hypothetical protein, conserved 0.0118 0.028 0.0878
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.028 0.0729
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0051 0.0003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0051 0.0126
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1146 0.3191 1
Plasmodium falciparum pyruvate kinase 0.0037 0.0051 0.016
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0072 0.015 0.0653
Onchocerca volvulus 0.0118 0.028 1
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0011 0.0035
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0572 0.1565 0.4904
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0572 0.1565 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0118 0.028 0.0878
Loa Loa (eye worm) hypothetical protein 0.0118 0.028 0.0846
Mycobacterium ulcerans lipase LipD 0.0118 0.028 0.0729
Mycobacterium tuberculosis Probable lipase LipE 0.0118 0.028 0.0732
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0395 0.1066 0.3231
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0566 0.155 0.4856
Schistosoma mansoni coup transcription factor 0.0023 0.0011 0.0035
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1146 0.3191 0.3191
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0141
Toxoplasma gondii ABC1 family protein 0.0118 0.028 0.0878
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0359 0.1124
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0291 0.0879
Entamoeba histolytica hypothetical protein 0.0077 0.0165 0.0942
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0572 0.1565 0.4821
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0011 0.0011
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1146 0.3191 1
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0051 0.1486
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0039 0.0056 0.0016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0092 0.0256
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0572 0.1565 1
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0395 0.1066 0.3233
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0011 0.0011
Brugia malayi hypothetical protein 0.0035 0.0046 0.011
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.028 0.0729
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0566 0.155 0.4838
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0026
Schistosoma mansoni hypothetical protein 0.0054 0.0098 0.0307
Loa Loa (eye worm) inositol-1 0.008 0.0174 0.0511
Trichomonas vaginalis myo inositol monophosphatase, putative 0.008 0.0174 0.0391
Trypanosoma cruzi polyprenyl synthase, putative 0.0566 0.155 0.4773
Schistosoma mansoni hypothetical protein 0.034 0.0909 0.2849
Trichomonas vaginalis myo inositol monophosphatase, putative 0.008 0.0174 0.0391
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0395 0.1066 0.3233
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0174 0.0391
Plasmodium falciparum acyl-CoA synthetase 0.0039 0.0056 0.0176
Loa Loa (eye worm) hypothetical protein 0.0118 0.028 0.0846
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0072 0.015 0.0318
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.028 0.0729
Echinococcus multilocularis beta LACTamase domain containing family member 0.0118 0.028 0.028
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0395 0.1066 0.3233
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0052 0.0093 0.0135
Loa Loa (eye worm) hypothetical protein 0.0118 0.028 0.0846
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0051 0.0126
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0101 0.0159
Brugia malayi Inositol-1 0.008 0.0174 0.0511
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0291 0.0879
Onchocerca volvulus 0.0118 0.028 1
Loa Loa (eye worm) hypothetical protein 0.0118 0.028 0.0846
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0395 0.1066 0.1066
Schistosoma mansoni trans-prenyltransferase 0.0572 0.1565 0.4904
Onchocerca volvulus 0.0054 0.0098 0.3227
Echinococcus granulosus inositol monophosphatase 1 0.008 0.0174 0.0545
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.0359 0.1093
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0011 0.0035
Leishmania major hypothetical protein, conserved 0.0118 0.028 0.0729
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0011 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0359 0.1124
Schistosoma mansoni hypothetical protein 0.0077 0.0165 0.0517
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0395 0.1066 0.677
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0011 0.0035
Entamoeba histolytica myo-inositol monophosphatase, putative 0.008 0.0174 0.0999
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0011 0.0011
Loa Loa (eye worm) polyprenyl synthetase 0.0572 0.1565 0.4886
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0753 0.208 0.6462
Entamoeba histolytica hypothetical protein 0.0077 0.0165 0.0942
Entamoeba histolytica acyl-coA synthetase, putative 0.0052 0.0093 0.0479
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0165 0.0517
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0174 0.0391
Brugia malayi beta-lactamase 0.0118 0.028 0.0846
Schistosoma mansoni hypothetical protein 0.0025 0.0016 0.0049
Mycobacterium ulcerans hypothetical protein 0.0118 0.028 0.0729
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0359 0.1124
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0093 0.0138
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0011 0.0011
Onchocerca volvulus 0.0052 0.0093 0.3056
Mycobacterium tuberculosis Conserved protein 0.0118 0.028 0.0732
Loa Loa (eye worm) hypothetical protein 0.0055 0.0101 0.0283
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0572 0.1565 0.4821
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0359 0.1124
Schistosoma mansoni inositol monophosphatase 0.008 0.0174 0.0545
Entamoeba histolytica hypothetical protein 0.0077 0.0165 0.0942
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0572 0.1565 0.4904
Trichomonas vaginalis penicillin-binding protein, putative 0.0118 0.028 0.0729
Mycobacterium ulcerans hypothetical protein 0.0052 0.0093 0.0135
Echinococcus granulosus pyruvate kinase 0.0037 0.0051 0.016
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0011 0.0011
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0101 0.0317
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0572 0.1565 1
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0011 0.0035
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0011 0.0035
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0051 0.016
Echinococcus multilocularis inositol monophosphatase 1 0.008 0.0174 0.0174
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0052 0.0093 0.0135
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0165 0.0165
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.0359 0.1093
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1146 0.3191 1
Mycobacterium ulcerans esterase/lipase LipP 0.0118 0.028 0.0729
Echinococcus granulosus survival motor neuron protein 1 0.0263 0.069 0.2164
Schistosoma mansoni inositol monophosphatase 0.008 0.0174 0.0545
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0052 0.0093 0.0135
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0118 0.028 0.0729
Brugia malayi Polyprenyl synthetase family protein 0.0572 0.1565 0.4886
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1146 0.3191 1
Trichomonas vaginalis esterase, putative 0.0118 0.028 0.0729
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0093 0.0135
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0011 0.0011
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0395 0.1066 0.6412
Echinococcus multilocularis survival motor neuron protein 1 0.0263 0.069 0.069
Echinococcus multilocularis pyruvate kinase 0.0029 0.0029 0.0029
Brugia malayi MH2 domain containing protein 0.0122 0.0291 0.0879
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0052 0.0093 0.0258
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0101 0.0317
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0118 0.028 0.0732
Brugia malayi beta-lactamase family protein 0.0118 0.028 0.0846
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0572 0.1565 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0092 0.0256
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0359 0.0359
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0011 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0093 0.0135
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0011 0.0035
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0174 0.0391
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0093 0.0279
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0011 0.0035
Mycobacterium leprae Probable lipase LipE 0.0118 0.028 0.1513
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0051 0.0126
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0051 0.0126
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0052 0.0093 0.0135
Schistosoma mansoni hypothetical protein 0.034 0.0909 0.2849
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1146 0.3191 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0118 0.028 0.0878
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0101 0.0317
Mycobacterium tuberculosis Probable lipase LipD 0.0118 0.028 0.0732
Brugia malayi beta-lactamase family protein 0.0118 0.028 0.0846
Echinococcus granulosus geminin 0.034 0.0909 0.2849
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0052 0.0093 0.0279
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0039 0.0056 0.0049
Loa Loa (eye worm) hypothetical protein 0.0052 0.0093 0.0258
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase) 0.0176 0.0445 0.1258
Plasmodium vivax acyl-CoA synthetase, putative 0.0039 0.0056 0.0176
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0011 0.0035
Schistosoma mansoni survival motor neuron protein 0.0054 0.0098 0.0307
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0359 0.1124
Loa Loa (eye worm) hypothetical protein 0.0118 0.028 0.0846
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0011 0.0035
Trypanosoma cruzi polyprenyl synthase, putative 0.0566 0.155 0.4773
Brugia malayi hypothetical protein 0.0263 0.069 0.2136
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0572 0.1565 0.4904
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1146 0.3191 1
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0093 0.0258
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0566 0.155 0.4856
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0051 0.1486
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0011 0.0035
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0011 0.0035
Onchocerca volvulus 0.0118 0.028 1
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0566 0.155 0.4838
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0093 0.0258
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0101 0.0159
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1146 0.3191 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0052 0.0093 0.0138
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0019 0.0026
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0011 0.0035
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0174 0.0391
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.008 0.0174 0.0545
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0395 0.1066 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0092 0.0256
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0395 0.1066 0.334
Brugia malayi AMP-binding enzyme family protein 0.0052 0.0093 0.0258
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0093 0.0479
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0093 0.0135
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1146 0.3191 1
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0572 0.1565 0.4821
Loa Loa (eye worm) hypothetical protein 0.0052 0.0093 0.0258
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1146 0.3191 1
Trichomonas vaginalis inositol monophosphatase, putative 0.008 0.0174 0.0391
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0359 0.0359
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0165 0.0517
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0118 0.028 0.0846
Mycobacterium tuberculosis Probable esterase LipL 0.0118 0.028 0.0732
Giardia lamblia Pyruvate kinase 0.0037 0.0051 0.016
Mycobacterium leprae conserved hypothetical protein 0.0118 0.028 0.1513
Leishmania major hypothetical protein, conserved 0.0055 0.0101 0.0159
Treponema pallidum octaprenyl-diphosphate synthase 0.0566 0.155 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0118 0.028 0.0729
Leishmania major solanesyl-diphosphate synthase, putative 0.0572 0.1565 0.4821
Leishmania major farnesyl pyrophosphate synthase 0.1146 0.3191 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0051 0.0126
Mycobacterium tuberculosis Conserved protein 0.0118 0.028 0.0732
Loa Loa (eye worm) polyprenyl synthetase 0.1146 0.3191 1
Brugia malayi Polyprenyl synthetase family protein 0.1146 0.3191 1
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0051 0.1486
Brugia malayi hypothetical protein 0.0077 0.0165 0.0484
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0118 0.028 0.0878
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0011 0.0011
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0572 0.1565 0.1565
Brugia malayi hypothetical protein 0.0055 0.0101 0.0283
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1146 0.3191 1
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0572 0.1565 0.4821
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0011 0.0035
Schistosoma mansoni pyruvate kinase 0.0037 0.0051 0.016
Loa Loa (eye worm) beta-lactamase 0.0118 0.028 0.0846
Echinococcus multilocularis pyruvate kinase 0.0037 0.0051 0.0051
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0566 0.155 0.155
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0118 0.028 0.0732
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0572 0.1565 0.4821
Trichomonas vaginalis D-aminoacylase, putative 0.0118 0.028 0.0729
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1146 0.3191 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0118 0.028 0.0729
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0572 0.1565 0.4904
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0051 0.016
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0098 0.0273
Entamoeba histolytica acyl-CoA synthetase, putative 0.0052 0.0093 0.0479
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0011 0.0035
Mycobacterium ulcerans beta-lactamase 0.0118 0.028 0.0729
Entamoeba histolytica hypothetical protein 0.0077 0.0165 0.0942
Mycobacterium ulcerans acyl-CoA synthetase 0.0052 0.0093 0.0135
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0011 0.0035
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0016 0.0049
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0101 0.0317
Giardia lamblia Farnesyl diphosphate synthase 0.1146 0.3191 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0118 0.028 0.0846
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0141
Leishmania major 4-coumarate:coa ligase-like protein 0.0052 0.0093 0.0135
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0011 0.0035
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0101 0.0159
Loa Loa (eye worm) hypothetical protein 0.0039 0.0056 0.0141

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.