Detailed information for compound 540645

Basic information

Technical information
  • TDR Targets ID: 540645
  • Name: bruceanic acid B
  • MW: 546.52 | Formula: C27H30O12
  • H donors: 3 H acceptors: 8 LogP: 0.66 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)C12OCC34C2C(OC(=O)c2ccccc2)C(=O)OC4CC(C(C3C(C1O)O)(C)CC(=O)O)C(=O)C
  • InChi: 1S/C27H30O12/c1-12(28)14-9-15-26-11-37-27(24(35)36-3,21(32)17(31)19(26)25(14,2)10-16(29)30)20(26)18(23(34)38-15)39-22(33)13-7-5-4-6-8-13/h4-8,14-15,17-21,31-32H,9-11H2,1-3H3,(H,29,30)
  • InChiKey: WPXXXQOSXRQJOB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 132616-54-7
  • 3,10-Ethano-1H,8H-furo(3,4-d)(1)benzopyran-9-acetic acid, 8-acetyl-4-(benzoyloxy)octahydro-11,12-dihydroxy-3-(methoxycarbonyl)-9-methyl-5-oxo-, (3S-(3alpha,3aalpha,4alpha,6aalpha,8alpha,9beta,10alpha,10aS*,11S*,12R*))-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0039 0.0034
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0059 0.0035
Schistosoma mansoni sugar transporter 0.0017 0.0039 0.0016
Brugia malayi Serotonin receptor 0.0024 0.0174 0.0325
Brugia malayi larval opioid receptor 0.0024 0.0174 0.0325
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.2462 1
Trypanosoma cruzi glucose transporter, putative 0.0017 0.0039 0.0323
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0225 0.0768
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0174 0.0151
Schistosoma mansoni biogenic amine receptor 0.0024 0.0174 0.0151
Onchocerca volvulus 0.0026 0.022 0.0625
Trypanosoma brucei glucose transporter, putative 0.0037 0.0421 0.8168
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0174 0.0151
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0174 0.0468
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.2695 0.5771
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0035 0.0398 0.0809
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0174 0.0325
Schistosoma mansoni hypothetical protein 0.0049 0.0663 0.0641
Schistosoma mansoni smad1 5 8 and 0.0018 0.0059 0.0035
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0174 0.0151
Plasmodium falciparum calcium-dependent protein kinase 5 0.0036 0.0413 0.042
Echinococcus granulosus transient receptor potential ion channel A 0.02 0.3544 0.3529
Plasmodium falciparum protein kinase 6 0.0501 0.928 1
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0421 0.0722
Brugia malayi G-protein coupled receptor 0.0024 0.0174 0.0325
Trypanosoma brucei glucose transporter, putative 0.0037 0.0421 0.8168
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Echinococcus multilocularis survival motor neuron protein 1 0.0257 0.4629 0.4616
Plasmodium vivax importin-beta 2, putative 0.0029 0.0267 0.0263
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0174 0.0151
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0018 0.007 0.0101
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0077 0.1193 0.2155
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0174 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.4601 0.8622
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0124 0.0108
Toxoplasma gondii sugar transporter ST1 0.0017 0.0039 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2924 0.5452
Entamoeba histolytica protein kinase, putative 0.0036 0.0412 0.0554
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0118 0.1974 0.1955
Plasmodium vivax CDK-related protein kinase 6, putative 0.0501 0.928 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0026 0.0225 0.0218
Echinococcus multilocularis snurportin 1 0.0305 0.5537 0.5527
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0421 0.0722
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0124 0.2055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0174 0.0151
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0406 0.0732
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0199 0.0189
Brugia malayi jmjC domain containing protein 0.0059 0.0851 0.1788
Onchocerca volvulus 0.0024 0.0174 0.0468
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0174 0.0151
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0026 0.0225 0.4145
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0036 0.0412 0.0744
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0164 0.0236
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0174 0.0315
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0174 0.0151
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0124 0.01
Brugia malayi major facilitator superfamily protein 0.0017 0.0039 0.0034
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0174 0.0315
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.2462 1
Schistosoma mansoni amine GPCR 0.0024 0.0174 0.0151
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0174 0.0151
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.0039 0.5
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0039 0.0071
Schistosoma mansoni smad 0.0018 0.0059 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0174 0.0151
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0174 0.0151
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0663 0.1198
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0174 0.0151
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0017 0.0039 0.0323
Echinococcus granulosus neuropeptide receptor 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0043
Schistosoma mansoni transient receptor potential channel 0.0137 0.2338 0.2319
Brugia malayi neuropeptide F receptor 0.0024 0.0174 0.0325
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0039 0.0034
Echinococcus granulosus importin subunit beta 1 0.0029 0.0267 0.0244
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0018 0.007 0.0101
Trypanosoma brucei glucose transporter, putative 0.0037 0.0421 0.8168
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0421 0.0722
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Leishmania major myo-inositol/proton symporter (MIT) 0.0017 0.0039 0.0323
Schistosoma mansoni protein kinase 0.0036 0.0412 0.039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0071
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0124 0.0108
Brugia malayi metabotropic glutamate receptor type 2 0.0024 0.0177 0.0332
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0174 0.0151
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0174 0.0325
Plasmodium falciparum calcium-dependent protein kinase 1 0.0036 0.0413 0.042
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0118 0.1974 0.1955
Echinococcus granulosus solute carrier family 22 0.0017 0.0039 0.0016
Plasmodium falciparum hexose transporter 0.0118 0.1974 0.2108
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0124 0.0165
Plasmodium falciparum lysine--tRNA ligase 0.0026 0.0225 0.0218
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0174 0.0151
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0421 0.0722
Plasmodium vivax sugar transporter, putative 0.0017 0.0039 0.0017
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.28 0.2783
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0019 0.0089 0.0066
Trypanosoma brucei glucose transporter, putative 0.0037 0.0421 0.8168
Entamoeba histolytica hypothetical protein 0.0036 0.0402 0.0535
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0207 0.3676 0.6639
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0421 0.8168
Loa Loa (eye worm) hypothetical protein 0.0018 0.007 0.0127
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0406 0.0692
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0663 0.1382
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0036 0.0412 0.7986
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0059 0.0106
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0406 0.0692
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0174 0.0325
Onchocerca volvulus 0.0024 0.0174 0.0468
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0174 0.0151
Echinococcus multilocularis GPCR, family 2 0.0049 0.0663 0.0641
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0406 0.0542
Echinococcus multilocularis calcium dependent protein kinase 0.0034 0.037 0.0347
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0174 0.0151
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0174 0.0315
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0018 0.007 0.0127
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0412 0.0705
Brugia malayi MH2 domain containing protein 0.0018 0.0059 0.0076
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0851 0.0829
Echinococcus multilocularis somatostatin receptor 0.0024 0.0174 0.0151
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.533 1
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0412 0.039
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0026 0.022 0.0397
Schistosoma mansoni hypothetical protein 0.0024 0.0174 0.0151
Schistosoma mansoni hypothetical protein 0.0539 1 1
Trypanosoma brucei glucose transporter, putative 0.0037 0.0421 0.8168
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0174 0.0151
Leishmania major GTP-binding protein, putative 0.0021 0.0124 0.2055
Loa Loa (eye worm) hypothetical protein 0.0263 0.4745 0.8568
Schistosoma mansoni protein kinase 0.0036 0.0412 0.039
Schistosoma mansoni alpha-glucosidase 0.0139 0.2372 0.2354
Echinococcus multilocularis solute carrier family 22 0.0017 0.0039 0.0016
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0174 0.0315
Echinococcus granulosus aryl hydrocarbon receptor 0.0026 0.022 0.0197
Brugia malayi follicle stimulating hormone receptor 0.0024 0.0174 0.0325
Giardia lamblia Fructose-bisphosphate aldolase 0.0294 0.533 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0059 0.0035
Trichomonas vaginalis sugar transporter, putative 0.0037 0.0421 0.0722
Schistosoma mansoni opsin-like receptor 0.0024 0.0174 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0406 0.7851
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Loa Loa (eye worm) hypothetical protein 0.0036 0.0412 0.0744
Plasmodium falciparum calcium-dependent protein kinase 2 0.0036 0.0413 0.042
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0174 0.0151
Trypanosoma brucei glucose transporter, putative 0.0037 0.0421 0.8168
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0174 0.0151
Schistosoma mansoni sugar transporter 0.0017 0.0039 0.0016
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0663 0.1382
Echinococcus granulosus somatostatin receptor 0.0024 0.0174 0.0151
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0035 0.0398 0.0528
Plasmodium vivax hexose transporter 0.0118 0.1974 0.2108
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0174 0.0315
Onchocerca volvulus Protein cycle homolog 0.0018 0.007 0.0108
Loa Loa (eye worm) hypothetical protein 0.0026 0.0225 0.0407
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0421 0.8168
Onchocerca volvulus 0.0024 0.0174 0.0468
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0059 0.0035
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.007 0.1061 0.1916
Loa Loa (eye worm) hypothetical protein 0.0098 0.1596 0.2882
Schistosoma mansoni opsin-like receptor 0.0024 0.0174 0.0151
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0026 0.022 0.0397
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.533 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.533 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0039 0.0016
Loa Loa (eye worm) sugar transporter 0.0118 0.1974 0.3566
Onchocerca volvulus 0.0024 0.0174 0.0468
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0174 0.0151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0174 0.0151
Onchocerca volvulus 0.0024 0.0174 0.0468
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0018 0.007 0.0047
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0174 0.0315
Trypanosoma cruzi hexose transporter 0.0037 0.0421 0.8168
Schistosoma mansoni biogenic amine receptor 0.0024 0.0174 0.0151
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0412 0.039
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.032
Entamoeba histolytica hypothetical protein 0.0026 0.0225 0.0195
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0174 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.1974 0.3658
Schistosoma mansoni alpha-glucosidase 0.0139 0.2372 0.2354
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0071
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0059 0.0106
Echinococcus granulosus allatostatin A receptor 0.0024 0.0174 0.0151
Echinococcus granulosus General substrate transporter 0.0102 0.1658 0.1638
Brugia malayi neuropeptide F receptor 0.0024 0.0174 0.0325
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0174 0.0151
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0174 0.0151
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0406 0.0383
Echinococcus granulosus g protein coupled receptor 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Echinococcus granulosus snurportin 1 0.0305 0.5537 0.5527
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.533 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.28 0.2783
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.4601 0.8622
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0199 0.3602
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0026 0.0225 0.0768
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0406 0.0692
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0024 0.0043
Loa Loa (eye worm) hypothetical protein 0.0257 0.4629 0.836
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0174 0.0325
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0174 0.0151
Echinococcus granulosus neuropeptide receptor A26 0.0024 0.0174 0.0151
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0174 0.0151
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0421 0.8168
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0039 0.0016
Echinococcus granulosus calcium dependent protein kinase 0.0034 0.037 0.0347
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0174 0.0151
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.533 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0174 0.0325
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0412 0.039
Onchocerca volvulus 0.0024 0.0174 0.0468
Onchocerca volvulus 0.0024 0.0174 0.0468
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0174 0.0151
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0398 0.0376
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0174 0.0151
Schistosoma mansoni glucose transport protein 0.0118 0.1974 0.1955
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2924 0.5452
Echinococcus multilocularis neuropeptide receptor A26 0.0024 0.0174 0.0151
Schistosoma mansoni neuropeptide receptor 0.0024 0.0174 0.0151
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0174 0.0151
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0663 0.0641
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.533 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0077 0.1193 0.1172
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0406 0.063
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0124 0.2055
Onchocerca volvulus 0.0024 0.0174 0.0468
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.051 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0071
Brugia malayi hypothetical protein 0.0026 0.022 0.0424
Brugia malayi RE15519p 0.0024 0.0174 0.0325
Toxoplasma gondii sugar transporter ST2 0.0017 0.0039 0.0026
Brugia malayi Dopamine receptor 0.0024 0.0174 0.0325
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0294 0.533 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.28 0.5999
Loa Loa (eye worm) hypothetical protein 0.0107 0.1754 0.3168
Schistosoma mansoni survival motor neuron protein 0.0052 0.0723 0.0701
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0174 0.0151
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0723 0.1512
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0851 0.0829
Brugia malayi ORL1-like opioid receptor 0.0024 0.0174 0.0325
Brugia malayi hypothetical protein 0.0024 0.0174 0.0325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0174 0.0151
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0174 0.0151
Entamoeba histolytica hypothetical protein 0.0023 0.0164 0.0078
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0174 0.0151
Onchocerca volvulus 0.0024 0.0174 0.0468
Echinococcus multilocularis smad 0.0018 0.0059 0.0035
Brugia malayi Sugar transporter family protein 0.0118 0.1974 0.4215
Schistosoma mansoni amine GPCR 0.0024 0.0174 0.0151
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0098 0.1596 0.5396
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0663 0.0641
Brugia malayi Melatonin receptor type 1A 0.0024 0.0174 0.0325
Brugia malayi Serotonin receptor 0.0024 0.0174 0.0325
Schistosoma mansoni amine GPCR 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.013 0.2206 0.3983
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0174 0.0151
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0406 0.0542
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0036 0.0413 0.0642
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0663 0.0641
Schistosoma mansoni hypothetical protein 0.0049 0.0663 0.0641
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0174 0.0151
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0174 0.0151
Trypanosoma brucei glucosidase, putative 0.0036 0.0406 0.7851
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0118 0.1974 0.1955
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0225 0.0202
Echinococcus multilocularis solute carrier family 22 0.0017 0.0039 0.0016
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0174 0.0325
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0174 0.0151
Onchocerca volvulus 0.0024 0.0174 0.0468
Schistosoma mansoni neuropeptide receptor 0.0024 0.0174 0.0151
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0174 0.0151
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0124 0.0223
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0174 0.0151
Schistosoma mansoni ran 0.0021 0.0124 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.4601 0.8622
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0174 0.0468
Plasmodium vivax calcium-dependent protein kinase, putative 0.0036 0.0413 0.042
Loa Loa (eye worm) hypothetical protein 0.0029 0.0267 0.0483
Brugia malayi G protein-coupled receptor 0.0024 0.0174 0.0325
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0174 0.0151
Brugia malayi lysyl-tRNA synthetase 0.0026 0.0225 0.0436
Trypanosoma cruzi sugar transporter, putative 0.0017 0.0039 0.0323
Loa Loa (eye worm) hypothetical protein 0.0029 0.0272 0.049
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0412 0.039
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2924 0.5452
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0124 0.2055
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0174 0.0151
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0174 0.0151
Giardia lamblia Lysyl-tRNA synthetase 0.0026 0.0225 0.0352
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0174 0.0151
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0024 0.0043
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0406 0.0692
Brugia malayi Transient-receptor-potential like protein 0.0077 0.1193 0.2527
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0174 0.0151
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0191 0.3361 0.5507
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0199 0.0189
Entamoeba histolytica heat shock transcription factor, putative 0.0098 0.1596 0.2827
Leishmania major glucose transporter, lmgt1 0.0037 0.0421 0.8168
Brugia malayi hypothetical protein 0.0024 0.0174 0.0325
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.4601 0.8622
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.051 1
Onchocerca volvulus 0.0052 0.0723 0.2372
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0174 0.0151
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0406 0.0825
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0035 0.0398 0.1076
Schistosoma mansoni myosin xvIII 0.0024 0.0174 0.0151
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0851 0.1537
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0035 0.0398 0.0376
Echinococcus multilocularis aryl hydrocarbon receptor 0.0026 0.022 0.0197
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0199 0.3602
Brugia malayi hypothetical protein 0.0036 0.0402 0.0818
Onchocerca volvulus 0.0024 0.0174 0.0468
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0174 0.0151
Loa Loa (eye worm) glutamate receptor 0.0019 0.0089 0.0161
Schistosoma mansoni sugar transporter 0.0017 0.0039 0.0016
Echinococcus granulosus sex peptide receptor 0.0024 0.0174 0.0151
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0059 0.0035
Schistosoma mansoni hypothetical protein 0.0049 0.0663 0.0641
Treponema pallidum fructose-bisphosphate aldolase 0.0294 0.533 0.5
Echinococcus multilocularis lysyl tRNA synthetase 0.0026 0.0225 0.0202
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0071
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0174 0.0151
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0036 0.0413 0.0642
Loa Loa (eye worm) Smad1 0.0018 0.0059 0.0106
Brugia malayi MH1 domain containing protein 0.0018 0.0059 0.0076
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0164 0.2893
Schistosoma mansoni Smad4 0.0018 0.0059 0.0035
Echinococcus multilocularis short transient receptor potential channel 6 0.0137 0.2338 0.2319
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.4601 0.989
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0174 0.0151
Schistosoma mansoni hypothetical protein 0.0036 0.0402 0.038
Chlamydia trachomatis lysine--tRNA ligase 0.0026 0.0225 0.5
Echinococcus granulosus serotonin receptor 0.0024 0.0174 0.0151
Echinococcus multilocularis sex peptide receptor 0.0024 0.0174 0.0151
Echinococcus granulosus Smad4 0.0018 0.0059 0.0035
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0118 0.1974 0.1955
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0851 0.0829
Brugia malayi hypothetical protein 0.0024 0.0174 0.0325
Schistosoma mansoni hypothetical protein 0.0052 0.0723 0.0701
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0174 0.0151
Leishmania major lysyl-tRNA synthetase, putative 0.0026 0.0225 0.4145
Brugia malayi hypothetical protein 0.0257 0.4629 0.995
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0174 0.0151
Brugia malayi Importin beta-1 subunit 0.0029 0.0267 0.0527
Schistosoma mansoni glucose transporter 0.0017 0.0039 0.0016
Brugia malayi MH2 domain containing protein 0.0259 0.4652 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.2695 0.4867
Brugia malayi hypothetical protein 0.0024 0.0174 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0421 0.0722
Loa Loa (eye worm) hypothetical protein 0.0263 0.4745 0.8568
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0022 0.015 0.0455
Echinococcus granulosus neuropeptide s receptor 0.0024 0.0174 0.0151
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0174 0.0315
Plasmodium vivax proline--tRNA ligase, putative 0.0041 0.051 0.0526
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0174 0.0151
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0851 0.0829
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0022 0.015 0.0455
Loa Loa (eye worm) hypothetical protein 0.0018 0.007 0.0127
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0041 0.051 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0039 0.0071
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0174 0.0151
Plasmodium falciparum calcium-dependent protein kinase 4 0.0036 0.0413 0.042
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.533 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0663 0.0641
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Brugia malayi Major Facilitator Superfamily protein 0.0017 0.0039 0.0034
Brugia malayi Smad1 0.0018 0.0059 0.0076
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0071
Echinococcus granulosus neuropeptide receptor 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0071
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0174 0.0151
Brugia malayi MH1 domain containing protein 0.0018 0.0059 0.0076
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Trypanosoma brucei glucose transporter 1E 0.0037 0.0421 0.8168
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0267 0.501
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0406 0.7851
Toxoplasma gondii sugar transporter ST3 0.0017 0.0039 0.0026
Entamoeba histolytica hypothetical protein 0.0036 0.0402 0.0535
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0174 0.0315
Brugia malayi AKH receptor 0.0024 0.0174 0.0325
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.4601 0.8309
Echinococcus granulosus orexin receptor type 2 0.0024 0.0174 0.0151
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0174 0.0151
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0039 0.0323
Schistosoma mansoni hypothetical protein 0.0539 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0406 0.0692
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0174 0.0151
Echinococcus multilocularis short transient receptor potential channel 6 0.0137 0.2338 0.2319
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0406 0.0692
Schistosoma mansoni hypothetical protein 0.0118 0.1974 0.1955
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0026 0.0225 0.0352
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0124 0.01
Echinococcus multilocularis serotonin receptor 0.0263 0.4745 0.4732
Echinococcus granulosus GPCR family 2 0.0049 0.0663 0.0641
Echinococcus granulosus biogenic amine 5HT receptor 0.0263 0.4745 0.4732
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0039 0.0016
Brugia malayi hypothetical protein 0.0018 0.007 0.0101
Schistosoma mansoni neuropeptide receptor 0.0024 0.0174 0.0151
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0059 0.0035
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0118 0.1974 0.1955
Entamoeba histolytica heat shock transcription factor, putative 0.0098 0.1596 0.2827
Onchocerca volvulus 0.0024 0.0174 0.0468
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0071
Schistosoma mansoni ran 0.0021 0.0124 0.01
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0026 0.0225 0.4145
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0174 0.0151
Entamoeba histolytica heat shock transcription factor, putative 0.0098 0.1596 0.2827
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0118 0.1974 0.1955
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0039 0.0016
Echinococcus granulosus g protein coupled receptor 0.0024 0.0174 0.0151
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0024 0.0174 0.0151
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0851 0.0829
Brugia malayi hypothetical protein 0.0024 0.0174 0.0325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0174 0.0151
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0412 0.039
Onchocerca volvulus 0.0024 0.0174 0.0468
Echinococcus multilocularis transient receptor potential ion channel A 0.02 0.3544 0.3529
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0071
Toxoplasma gondii lysine-tRNA ligase 0.0026 0.0225 0.0333
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0174 0.0151
Echinococcus granulosus lysyl tRNA synthetase 0.0026 0.0225 0.0202
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.2924 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Brugia malayi HSF-type DNA-binding domain containing protein 0.0098 0.1596 0.3396
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0402 0.038
Echinococcus granulosus solute carrier family 22 0.0017 0.0039 0.0016
Brugia malayi Dopamine receptor protein 2 0.0024 0.0174 0.0325
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Brugia malayi hypothetical protein 0.0024 0.0174 0.0325
Brugia malayi hypothetical protein 0.0017 0.0039 0.0034
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.5537 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0039 0.0016
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0267 0.501
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0402 0.038
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0071
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0071
Schistosoma mansoni hypothetical protein 0.0024 0.0174 0.0151
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0174 0.0151
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0164 0.0236
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0174 0.0151
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0174 0.0151
Schistosoma mansoni hypothetical protein 0.0107 0.1754 0.1735
Brugia malayi hypothetical protein 0.0017 0.0039 0.0034
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0036 0.0413 0.0642
Schistosoma mansoni biogenic amine receptor 0.0024 0.0174 0.0151
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0036 0.0412 0.0744
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0412 0.039
Schistosoma mansoni biogenic amine (5HT) receptor 0.0263 0.4745 0.4732
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0071
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2924 0.5452
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0043
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0199 0.0289
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0199 0.3602
Trypanosoma brucei glucose transporter, putative 0.0037 0.0421 0.8168
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2924 0.5452
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0163 0.0234
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0406 0.7851
Onchocerca volvulus 0.0024 0.0174 0.0468
Echinococcus granulosus short transient receptor potential channel 6 0.0137 0.2338 0.2319
Loa Loa (eye worm) hypothetical protein 0.0018 0.007 0.0127
Toxoplasma gondii facilitative glucose transporter GT1 0.0118 0.1974 0.3219
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Echinococcus granulosus metabotropic glutamate receptor 5 0.0024 0.0177 0.0154
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Onchocerca volvulus 0.0024 0.0174 0.0468
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0406 0.0692
Plasmodium falciparum proline--tRNA ligase 0.0041 0.051 0.0526
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0018 0.007 0.0101
Leishmania major protein kinase, putative 0.0036 0.0412 0.7986
Toxoplasma gondii protein kinase, putative 0.0334 0.6085 1
Schistosoma mansoni amine GPCR 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0174 0.0325
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Trypanosoma brucei sugar transporter, putative 0.0017 0.0039 0.0323
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Echinococcus granulosus transient receptor potential gamma protein 0.0207 0.3676 0.3661
Plasmodium falciparum protein kinase 7 0.0334 0.6085 0.6548
Echinococcus granulosus solute carrier family 22 0.0017 0.0039 0.0016
Schistosoma mansoni sugar transporter 0.0017 0.0039 0.0016
Schistosoma mansoni protein kinase 0.0036 0.0412 0.039
Loa Loa (eye worm) hypothetical protein 0.0018 0.007 0.0127
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0071
Brugia malayi G-protein coupled receptor 0.0024 0.0174 0.0325
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0036 0.0413 0.042
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0421 0.8168
Brugia malayi hypothetical protein 0.0017 0.0039 0.0034
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0267 0.0244
Echinococcus granulosus TRP transient receptor potential channel 0.0077 0.1193 0.1172
Echinococcus multilocularis transient receptor potential gamma protein 0.0207 0.3676 0.3661
Trichomonas vaginalis glucose transporter, putative 0.0037 0.0421 0.0722
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0174 0.0315
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0164 0.0236
Schistosoma mansoni lysyl-tRNA synthetase 0.0026 0.0225 0.0202
Schistosoma mansoni smad1 5 8 and 0.0018 0.0059 0.0035
Brugia malayi hypothetical protein 0.0025 0.0199 0.0379
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0174 0.0325
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0118 0.1974 0.1955
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0124 0.0216
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.533 1
Brugia malayi sulfakinin receptor protein 0.0024 0.0174 0.0325
Schistosoma mansoni metabotropic glutamate receptor 0.016 0.2774 0.2756
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0036 0.0413 0.042
Brugia malayi hypothetical protein 0.0024 0.0174 0.0325
Loa Loa (eye worm) hypothetical protein 0.0049 0.0663 0.1198
Echinococcus multilocularis neuropeptide s receptor 0.0024 0.0174 0.0151
Loa Loa (eye worm) MH2 domain-containing protein 0.0259 0.4652 0.8401
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0174 0.0315
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0174 0.0151
Loa Loa (eye worm) transcription factor SMAD2 0.0259 0.4652 0.8401
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2924 0.5452
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0124 0.0159
Onchocerca volvulus 0.0093 0.1503 0.5074
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0174 0.0151
Leishmania major hypothetical protein, conserved 0.0017 0.0039 0.0323
Echinococcus multilocularis solute carrier family 22 0.0017 0.0039 0.0016
Leishmania major importin beta-1 subunit, putative 0.0023 0.0164 0.2893
Schistosoma mansoni glucose transport protein 0.0118 0.1974 0.1955
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0118 0.1974 0.1955
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0071
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0024 0.0174 0.0151
Schistosoma mansoni transient receptor potential channel 0.0207 0.3676 0.3661
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.3096 0.5777
Schistosoma mansoni transient receptor potential channel 4 0.0207 0.3676 0.3661
Schistosoma mansoni hypothetical protein 0.0305 0.5537 0.5527
Echinococcus multilocularis geminin 0.0539 1 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0406 0.0383
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0036 0.0412 0.084
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0035 0.0398 0.0809
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.4601 0.8622
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0035 0.0398 0.0376
Brugia malayi Sugar transporter family protein 0.0017 0.0039 0.0034
Schistosoma mansoni hypothetical protein 0.0049 0.0663 0.0641
Brugia malayi hypothetical protein 0.0024 0.0174 0.0325
Brugia malayi GnHR receptor homolog 0.0024 0.0174 0.0325
Schistosoma mansoni hypothetical protein 0.0024 0.0174 0.0151
Echinococcus multilocularis General substrate transporter 0.0102 0.1658 0.1638
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0174 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.2924 0.5452
Loa Loa (eye worm) sugar transporter 0.0017 0.0039 0.0071
Echinococcus granulosus smad 0.0018 0.0059 0.0035
Loa Loa (eye worm) hypothetical protein 0.0017 0.0039 0.0071
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.051 1
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0174 0.0151
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.28 0.2783
Entamoeba histolytica hypothetical protein 0.0036 0.0402 0.0535
Schistosoma mansoni alpha glucosidase 0.0036 0.0406 0.0383
Schistosoma mansoni neuropeptide receptor 0.0024 0.0174 0.0151
Brugia malayi jmjC domain containing protein 0.0059 0.0851 0.1788
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0174 0.0151
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0174 0.0151
Schistosoma mansoni histamine h1 receptor 0.0024 0.0174 0.0151
Brugia malayi Dopamine receptor protein 1 0.0024 0.0174 0.0325
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0043
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0036 0.0413 0.042
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0041 0.051 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0174 0.0151
Plasmodium falciparum calcium-dependent protein kinase 3 0.0036 0.0413 0.042
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0174 0.0151
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.2462 1
Onchocerca volvulus 0.0024 0.0174 0.0468
Brugia malayi hypothetical protein 0.0024 0.0174 0.0325
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0024 0.0177 0.0154
Loa Loa (eye worm) hypothetical protein 0.0156 0.2695 0.4867
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0406 0.0692
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0035 0.0398 0.0678
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0174 0.0151
Leishmania major hypothetical protein, conserved 0.0025 0.0199 0.3602
Schistosoma mansoni smad1 5 8 and 0.0018 0.0059 0.0035
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Brugia malayi hypothetical protein 0.0018 0.007 0.0101
Echinococcus multilocularis Smad4 0.0018 0.0059 0.0035
Brugia malayi hypothetical protein 0.0024 0.0174 0.0325
Schistosoma mansoni adenoreceptor 0.0024 0.0174 0.0151
Brugia malayi major facilitator superfamily protein 0.0017 0.0039 0.0034
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0174 0.0151
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.1754 0.374
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0026 0.0225 0.0328
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0174 0.0151
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0421 0.8168
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0024 0.0174 0.0151
Onchocerca volvulus 0.0024 0.0174 0.0468
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0017 0.0039 0.0017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0199 0.0359
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0174 0.0151
Echinococcus granulosus short transient receptor potential channel 6 0.0137 0.2338 0.2319
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0294 0.533 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0174 0.0151
Trypanosoma brucei glucose transporter, putative 0.0037 0.0421 0.8168
Trichomonas vaginalis ran, putative 0.0021 0.0124 0.0159
Brugia malayi hypothetical protein 0.0016 0.003 0.0014
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0402 0.038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0174 0.0151
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0174 0.0151
Schistosoma mansoni importin beta-1 0.0029 0.0267 0.0244
Schistosoma mansoni glucose transport protein 0.0118 0.1974 0.1955
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0036 0.0412 0.039
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0174 0.0151
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0036 0.0412 0.039
Echinococcus granulosus fmrfamide receptor 0.0024 0.0174 0.0151
Brugia malayi MH2 domain containing protein 0.0018 0.0059 0.0076
Trypanosoma brucei glucose transporter 2A 0.0037 0.0421 0.8168
Loa Loa (eye worm) hypothetical protein 0.0035 0.0398 0.0719
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0041 0.051 0.0803
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0024 0.0174 0.0315
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.28 0.5057
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0035 0.0398 0.0376
Echinococcus granulosus survival motor neuron protein 1 0.0257 0.4629 0.4616
Trypanosoma cruzi hexose transporter, putative 0.002 0.0104 0.1661
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0851 0.0829
Brugia malayi putative neuropeptide receptor 0.0024 0.0174 0.0325
Schistosoma mansoni hypothetical protein 0.0024 0.0174 0.0151
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0851 0.0829
Schistosoma mansoni amine GPCR 0.0024 0.0174 0.0151
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0199 0.0189
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.2695 0.5771
Brugia malayi RNA, U transporter 1 0.0081 0.1272 0.2696
Entamoeba histolytica hypothetical protein 0.0036 0.0402 0.0535
Brugia malayi Cam kinase protein 1 0.0036 0.0412 0.084
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.4601 0.8622
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0036 0.0412 0.039
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Plasmodium falciparum mitogen-activated protein kinase 2 0.0191 0.3361 0.3606
Echinococcus multilocularis serotonin receptor 0.0263 0.4745 0.4732
Echinococcus granulosus solute carrier family 22 0.0017 0.0039 0.0016
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Schistosoma mansoni transient receptor potential channel 0.0137 0.2338 0.2319
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0406 0.0692
Giardia lamblia Prolyl-tRNA synthetase 0.0035 0.0398 0.0678
Trypanosoma brucei THT1 - hexose transporter, putative 0.0037 0.0421 0.8168
Loa Loa (eye worm) hypothetical protein 0.0024 0.0174 0.0315
Leishmania major glucose transporter/membrane transporter D2, putative 0.0037 0.0421 0.8168
Echinococcus granulosus hypothetical protein 0.0024 0.0174 0.0151
Loa Loa (eye worm) hypothetical protein 0.0035 0.0398 0.0719
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0191 0.3361 0.3606
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0024 0.0043
Echinococcus multilocularis solute carrier family 22 0.0017 0.0039 0.0016
Leishmania major glucose transporter, lmgt3 0.0037 0.0421 0.8168
Plasmodium falciparum importin beta, putative 0.0029 0.0267 0.0263
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0174 0.0151
Echinococcus granulosus g protein coupled receptor 0.0024 0.0174 0.0151
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0174 0.0151
Schistosoma mansoni opsin-like receptor 0.0024 0.0174 0.0151
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0267 0.0402
Brugia malayi Sugar transporter family protein 0.0017 0.0039 0.0034
Toxoplasma gondii transporter, major facilitator family protein 0.0017 0.0039 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.3096 0.5777
Entamoeba histolytica protein kinase, putative 0.0036 0.0412 0.0554
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0174 0.0151
Leishmania major glucose transporter, lmgt2 0.0037 0.0421 0.8168

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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