Detailed information for compound 547142

Basic information

Technical information
  • TDR Targets ID: 547142
  • Name: zinc dodecane disulfate
  • MW: 427.84 | Formula: C12H26O8S2Zn--
  • H donors: 0 H acceptors: 8 LogP: 3.63 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]S(=O)(=O)[O-].[O-]S(=O)(=O)[O-].CCCCCCCCCCCC.[Zn+2]
  • InChi: 1S/C12H26.2H2O4S.Zn/c1-3-5-7-9-11-12-10-8-6-4-2;2*1-5(2,3)4;/h3-12H2,1-2H3;2*(H2,1,2,3,4);/q;;;+2/p-4
  • InChiKey: MFXAFJHONPALGF-UHFFFAOYSA-J  


Substructure search Similarity search

Network

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Synonyms

  • 22397-58-6
  • 151-41-7
  • EINECS 244-955-3
  • Zinc dodecyl hydrogen disulphate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0025 0.0144 0.0199
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0149
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0248 0.0918
Loa Loa (eye worm) hypothetical protein 0.0035 0.0248 0.0928
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0014 0.004 0.0007
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0281 0.2675 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0012 0.0019 0.0019
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0011 0.0003 0.0003
Echinococcus multilocularis protocadherin 11 0.0011 0.0003 0.0003
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.1003 0.3744
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0035 0.0032
Echinococcus multilocularis voltage dependent calcium channel subunit 0.077 0.7496 0.7496
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0099 0.0359
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0032 0.0371
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.03 0.1058
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0099 0.0302
Echinococcus multilocularis regulator of G protein signaling 7 0.0031 0.02 0.02
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0035 0.0141
Mycobacterium ulcerans aminopeptidase N PepN 0.0025 0.0144 0.0941
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0149
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0025 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0012 0.0019 0.007
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0256 0.0894
Loa Loa (eye worm) hypothetical protein 0.0016 0.0054 0.0201
Toxoplasma gondii aminopeptidase n, putative 0.0631 0.6123 1
Onchocerca volvulus 0.0014 0.004 0.0184
Entamoeba histolytica hypothetical protein, conserved 0.0014 0.004 0.0472
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0149
Schistosoma mansoni hypothetical protein 0.0014 0.004 0.0052
Loa Loa (eye worm) bZIP transcription factor family protein 0.0011 0.0003 0.001
Entamoeba histolytica hypothetical protein, conserved 0.0014 0.004 0.0472
Echinococcus granulosus cpg binding protein 0.0035 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0142 0.1296 0.4846
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0519 0.0795
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0256 0.0256
Echinococcus granulosus hyperpolarization activated cyclic 0.0012 0.0019 0.0019
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.151 0.151
Brugia malayi Thioredoxin reductase 0.004 0.0294 0.1088
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0032 0.005
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0035 0.0141
Echinococcus multilocularis hyperpolarization activated cyclic 0.0012 0.0019 0.0019
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0248 0.0928
Onchocerca volvulus 0.0014 0.004 0.0184
Loa Loa (eye worm) hypothetical protein 0.0077 0.0654 0.2444
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0025 0.0144 0.0144
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0014 0.004 0.0149
Loa Loa (eye worm) hypothetical protein 0.0013 0.0032 0.0119
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.2675 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0099 0.0135
Brugia malayi von Willebrand factor type A domain containing protein 0.0014 0.004 0.0138
Echinococcus granulosus protocadherin 11 0.0011 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0035 0.0248 0.0346
Echinococcus multilocularis cpg binding protein 0.0035 0.0245 0.0245
Schistosoma mansoni hypothetical protein 0.0035 0.0248 0.0346
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0099 0.0099
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0631 0.6123 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0035 0.0141
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0214 0.2008 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.151 0.151
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0294 0.1097
Brugia malayi von Willebrand factor type A domain containing protein 0.0014 0.004 0.0138
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0099 0.0099
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0035 0.0141
Loa Loa (eye worm) hypothetical protein 0.0112 0.1003 0.375
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.1192 1
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1818 0.6775
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.1192 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.039 0.039
Echinococcus multilocularis voltage gated potassium channel 0.0016 0.0054 0.0054
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.0144 0.4298
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0299 0.0299
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0101 0.09 0.7476
Brugia malayi glutathione reductase 0.004 0.0294 0.1088
Schistosoma mansoni hypothetical protein 0.0333 0.3185 0.4482
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0099 0.0099
Mycobacterium tuberculosis Probable oxidoreductase 0.0101 0.09 0.7476
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0101 0.09 0.7476
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.172 0.6406
Trypanosoma brucei Aminopeptidase M1, putative 0.0025 0.0144 0.4298
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0099 0.0099
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0099 0.0099
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0294 0.0424
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0149
Loa Loa (eye worm) TATA binding protein associated factor 0.0025 0.0144 0.0539
Brugia malayi hypothetical protein 0.0014 0.004 0.0138
Treponema pallidum hypothetical protein 0.0014 0.004 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0032 0.005
Trypanosoma brucei trypanothione reductase 0.004 0.0294 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0149
Brugia malayi hypothetical protein 0.002 0.0099 0.0359
Schistosoma mansoni axis inhibition protein axin 0.002 0.0099 0.0135
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0169 0.1569 0.2207
Brugia malayi TATA binding protein associated factor 0.0025 0.0144 0.053
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0256 0.1934
Onchocerca volvulus 0.0094 0.083 0.4127
Echinococcus granulosus transcriptional factor nfil3:e4bp4 0.0011 0.0003 0.0003
Brugia malayi CXXC zinc finger family protein 0.0033 0.0226 0.0836
Echinococcus granulosus regulator of G protein signaling 7 0.0031 0.02 0.02
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0248 0.0248
Echinococcus granulosus axis inhibition protein axin 0.002 0.0099 0.0099
Brugia malayi regulator of G-protein signaling egl-10 0.0031 0.02 0.0739
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0099 0.0135
Toxoplasma gondii microneme protein MIC2 0.0014 0.004 0.0007
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0025 0.0144 0.0199
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0144 0.097
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0099 0.0369
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0149
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0325 0.1205
Toxoplasma gondii thioredoxin reductase 0.004 0.0294 0.0424
Brugia malayi von Willebrand factor type A domain containing protein 0.0014 0.004 0.0138
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0012 0.0019 0.0019
Loa Loa (eye worm) cell death specification protein 2 0.0011 0.0003 0.001
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0099 0.0302
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0014 0.004 0.0007
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0012 0.0019 0.0019
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0101 0.09 1
Schistosoma mansoni cpg binding protein 0.0035 0.0245 0.0341
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0032 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.039 0.0546
Onchocerca volvulus 0.0025 0.0144 0.0706
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0144 0.0144
Loa Loa (eye worm) CUTiclin family member 0.0014 0.004 0.0149
Echinococcus granulosus GPCR family 2 0.0035 0.0248 0.0248
Echinococcus multilocularis hyperpolarization activated cyclic 0.0012 0.0019 0.0019
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0099 0.0369
Mycobacterium ulcerans aminopeptidase N PepN 0.0025 0.0144 0.0941
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.1003 0.3744
Schistosoma mansoni hypothetical protein 0.0473 0.4564 0.6425
Schistosoma mansoni hypothetical protein 0.0035 0.0248 0.0346
Echinococcus multilocularis aminopeptidase N 0.0025 0.0144 0.0144
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0099 0.0135
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0281 0.2675 1
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0099 0.0099
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0099 0.0135
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0131 0.1192 0.1192
Brugia malayi PXA domain containing protein 0.002 0.0099 0.0359
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0025 0.0144 0.0179
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.2675 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0256 0.0362
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0256 0.0894
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.001
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0032 0.005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.001
Schistosoma mansoni alpha-glucosidase 0.0141 0.1285 0.1807
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0099 0.0359
Schistosoma mansoni alpha glucosidase 0.0036 0.0256 0.0357
Schistosoma mansoni hypothetical protein 0.0174 0.1616 0.2272
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0035 0.0064
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.151 0.564
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.172 0.6406
Brugia malayi von Willebrand Factor 0.0014 0.004 0.0138
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0099 0.0302
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.2675 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0256 0.8572
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0012 0.0019 0.0022
Brugia malayi von Willebrand factor type A domain containing protein 0.0014 0.004 0.0138
Trypanosoma cruzi Aminopeptidase M1, putative 0.0025 0.0144 0.4298
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0256 0.8572
Schistosoma mansoni regulator of G protein signaling 0.002 0.0099 0.0135
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0144 0.0473
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0025 0.0144 0.4298
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.004 0.0138
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.1192 0.1675
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0014 0.004 0.0138
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0099 0.0359
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0539
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0149
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.001
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0256 0.0958
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0012 0.0019 0.007
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0091 0.0799 0.6607
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0011 0.0003 0.0003
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0294 0.2232
Toxoplasma gondii aminopeptidase N, putative 0.0631 0.6123 1
Onchocerca volvulus 0.0014 0.004 0.0184
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0035 0.0032
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0256 0.0894
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0032 0.0145
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0144 0.053
Echinococcus granulosus voltage dependent calcium channel subunit 0.077 0.7496 0.7496
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0019 0.0022
Echinococcus multilocularis transcriptional factor nfil3:e4bp4 0.0011 0.0003 0.0003
Plasmodium vivax thrombospondin-related anonymous protein 0.0014 0.004 0.0007
Echinococcus multilocularis microtubule associated protein 2 0.073 0.7102 0.7102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0035 0.0141
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0144 0.097
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0099 0.0302
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.0019 0.0022
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0012 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0214 0.2008 0.7508
Schistosoma mansoni axis inhibition protein axin 0.002 0.0099 0.0135
Echinococcus multilocularis GPCR, family 2 0.0035 0.0248 0.0248
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.0019 0.0022
Brugia malayi Cache domain containing protein 0.0155 0.1428 0.5335
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0011 0.0003 0.0003
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0299 0.0299
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0149
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0035 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.039 0.039
Echinococcus granulosus voltage dependent calcium channel subunit 0.035 0.3354 0.3354
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0099 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0099 0.0302
Giardia lamblia NADH oxidase lateral transfer candidate 0.0014 0.0035 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0035 0.0141
Loa Loa (eye worm) hypothetical protein 0.0155 0.1428 0.534
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0025 0.0144 0.0539
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0226 0.0846
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0256 0.0894
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.2675 1
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.0011 0.0003 0.0003
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0131 0.1192 1
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.036 0.0503
Entamoeba histolytica hypothetical protein 0.002 0.0099 0.1225
Echinococcus multilocularis X box binding protein 1 0.0333 0.3185 0.3185
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.039 0.039
Entamoeba histolytica aminopeptidase, putative 0.0025 0.0144 0.1806
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0035 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0016 0.0054 0.0054
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0035 0.0122
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0248 0.0248
Schistosoma mansoni regulator of G protein signaling 0.0031 0.02 0.0278
Brugia malayi hypothetical protein 0.002 0.0099 0.0359
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0014 0.004 0.004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0035 0.0141
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0054 0.0072
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0035 0.0141
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.172 0.6406
Echinococcus multilocularis protocadherin 11 0.0011 0.0003 0.0003
Echinococcus granulosus voltage gated potassium channel 0.0016 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0077 0.0654 0.0917
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0012 0.0019 0.0019
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0035 0.0141
Trypanosoma brucei Aminopeptidase M1, putative 0.0025 0.0144 0.4298
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0539
Onchocerca volvulus 0.0014 0.004 0.0184
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0032 0.005
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0025 0.0144 0.4298
Entamoeba histolytica hypothetical protein 0.002 0.0099 0.1225
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0091 0.0799 0.6607
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0369
Echinococcus multilocularis geminin 0.0174 0.1616 0.1616
Loa Loa (eye worm) RGS-3 protein 0.002 0.0099 0.0369
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0035 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1818 0.6775
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.0144 0.4298
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0014 0.004 0.0149
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0016 0.0054 0.0054
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0099 0.0359
Brugia malayi von Willebrand factor type A domain containing protein 0.0014 0.004 0.0138
Brugia malayi N-terminal motif family protein 0.0214 0.2008 0.7505
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0035 0.0032
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0144 0.0144
Echinococcus granulosus neuropeptide receptor A26 0.1024 1 1
Brugia malayi PXA domain containing protein 0.002 0.0099 0.0359
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0099 0.0135
Onchocerca volvulus Huntingtin homolog 0.0142 0.1296 0.6449
Echinococcus granulosus collagen alpha 1VII chain 0.0014 0.004 0.004
Mycobacterium tuberculosis Probable dehydrogenase 0.0091 0.0799 0.6607
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0256 0.0894
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0091 0.0799 0.6607
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0325 0.0325
Plasmodium falciparum thioredoxin reductase 0.004 0.0294 0.0424
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0144 0.097
Schistosoma mansoni alpha-glucosidase 0.0141 0.1285 0.1807
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.2675 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0012 0.0019 0.007
Toxoplasma gondii aminopeptidase N protein 0.0631 0.6123 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0014 0.004 0.0138
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0012 0.0019 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.172 0.6406
Onchocerca volvulus 0.0014 0.004 0.0184
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0149
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0149
Loa Loa (eye worm) peptidase family M1 containing protein 0.0025 0.0144 0.0539
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0014 0.004 0.0007
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.0654 0.2436
Onchocerca volvulus Huntingtin homolog 0.0142 0.1296 0.6449
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0035 0.0141
Entamoeba histolytica elongation factor-2 kinase, putative 0.0014 0.004 0.0472
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0032 0.0109
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0099 0.0369
Echinococcus granulosus axis inhibition protein axin 0.002 0.0099 0.0099
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0131 0.1192 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0369
Toxoplasma gondii aldehyde dehydrogenase 0.0131 0.1192 0.1899
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0012 0.0019 0.0019
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0144 0.0144
Onchocerca volvulus 0.0025 0.0144 0.0706
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0014 0.004 0.0007
Schistosoma mansoni hypothetical protein 0.0174 0.1616 0.2272
Echinococcus multilocularis neuropeptide s receptor 0.1024 1 1
Onchocerca volvulus 0.0014 0.004 0.0184
Echinococcus granulosus microtubule associated protein 2 0.073 0.7102 0.7102
Plasmodium falciparum thrombospondin-related anonymous protein 0.0014 0.004 0.0007
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0012 0.0019 0.0019
Trypanosoma cruzi aminopeptidase, putative 0.0025 0.0144 0.4298
Loa Loa (eye worm) hypothetical protein 0.009 0.0786 0.294
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0012 0.0019 0.0022
Brugia malayi Cyclic-nucleotide gated cation channel 0.0012 0.0019 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0099 0.0302
Entamoeba histolytica hypothetical protein 0.002 0.0099 0.1225
Onchocerca volvulus 0.0033 0.0226 0.1114
Echinococcus granulosus regulator of G protein signaling 7 0.0031 0.02 0.02
Trypanosoma brucei aminopeptidase, putative 0.0025 0.0144 0.4298
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0035 0.0035
Echinococcus granulosus dnaJ subfamily B 0.0473 0.4564 0.4564
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0025 0.0144 0.4298
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0041 0.03 0.1058
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.036 0.0503
Echinococcus multilocularis expressed protein 0.0395 0.3795 0.3795
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0369
Plasmodium vivax hypothetical protein, conserved 0.0014 0.004 0.0007
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0144 0.0144
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.151 0.5644
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.151 0.151
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.001
Echinococcus multilocularis dnaJ subfamily B 0.0473 0.4564 0.4564
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0054 0.0072
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0256 0.0894
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.039 0.1451
Schistosoma mansoni hypothetical protein 0.0181 0.1683 0.2367
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0099 0.0099
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0256 0.3233
Plasmodium vivax glutathione reductase, putative 0.004 0.0294 0.0424
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0012 0.0019 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.039 0.0546
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0149
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0248 0.0248
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0099 0.0099
Brugia malayi hypothetical protein 0.0142 0.1296 0.484
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0035 0.0141
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0014 0.004 0.008
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0149
Schistosoma mansoni cpg binding protein 0.0033 0.0226 0.0315
Schistosoma mansoni cpg binding protein 0.0035 0.0245 0.0341
Brugia malayi hypothetical protein 0.0025 0.0144 0.053
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0032 0.005
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0025 0.0144 0.0199
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0325 0.1214
Echinococcus multilocularis regulator of G protein signaling 7 0.0031 0.02 0.02
Echinococcus granulosus leukotriene A 4 hydrolase 0.0025 0.0144 0.0144
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.1192 1
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.172 0.6406
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0131 0.1192 0.1192
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0256 0.0948
Loa Loa (eye worm) hypothetical protein 0.0142 0.1296 0.4846
Loa Loa (eye worm) CUTiclin-Like family member 0.0014 0.004 0.0149
Loa Loa (eye worm) hypothetical protein 0.0034 0.023 0.0859
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0336 0.3213 0.4522
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0099 0.0359
Echinococcus granulosus protocadherin 11 0.0011 0.0003 0.0003
Onchocerca volvulus 0.0025 0.0144 0.0706
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0144 0.0144
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0144 0.053
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0144 0.0144
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0035 0.0141
Loa Loa (eye worm) hypothetical protein 0.0025 0.0144 0.0539
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.009 0.0786 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0016 0.0054 0.019
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0256 0.0894
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.009 0.0786 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0631 0.6123 1
Echinococcus granulosus expressed protein 0.0395 0.3795 0.3795
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0091 0.0799 0.6607
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0011 0.0003 0.0003
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0144 0.0473
Echinococcus multilocularis ccaat enhancer binding protein delta ccaat enhancer binding protein beta 0.0011 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0031 0.02 0.0748
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0593 0.0832
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0035 0.0032
Schistosoma mansoni hypothetical protein 0.0035 0.0248 0.0346
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.1003 0.375
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0149
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0144 0.0144
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.172 0.6406
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0099 0.0135
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0144 0.053
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0099 0.0099
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0031 0.02 0.0748
Brugia malayi Zona pellucida-like domain containing protein 0.0014 0.004 0.0138
Schistosoma mansoni z-protein (S1r protein) 0.0031 0.02 0.0278
Leishmania major trypanothione reductase 0.004 0.0294 0.2256
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0025 0.0144 0.0473
Echinococcus granulosus hyperpolarization activated cyclic 0.0012 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0149
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.039 0.039
Echinococcus multilocularis voltage dependent calcium channel subunit 0.035 0.3354 0.3354
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.172 0.6406
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0256 0.3233
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0014 0.0035 0.5
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0014 0.004 0.0007
Treponema pallidum 76K protein 0.0014 0.004 1
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.1192 0.1675
Loa Loa (eye worm) glutathione reductase 0.004 0.0294 0.1097
Entamoeba histolytica hypothetical protein 0.0014 0.004 0.0472
Schistosoma mansoni aminopeptidase A (M01 family) 0.0025 0.0144 0.0199
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0144 0.0144
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0032 0.005
Plasmodium falciparum glutathione reductase 0.004 0.0294 0.0424
Brugia malayi Zona pellucida-like domain containing protein 0.0014 0.004 0.0138
Echinococcus granulosus geminin 0.0174 0.1616 0.1616
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0144 0.0179
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0248 0.0918
Echinococcus multilocularis neuropeptide receptor A26 0.1024 1 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0144 0.4298
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0035 0.0064
Schistosoma mansoni serine-rich repeat protein 0.0181 0.1683 0.2367
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0032 0.005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.039 0.0546
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0099 0.0135
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0256 0.0256
Echinococcus granulosus X box binding protein 1 0.0333 0.3185 0.3185
Schistosoma mansoni regulator of G protein signaling 0.002 0.0099 0.0135
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0325 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0099 0.0302
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0144 0.0144
Brugia malayi von Willebrand factor type A domain containing protein 0.0014 0.004 0.0138
Brugia malayi hypothetical protein 0.0025 0.0144 0.053
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0035 0.0035
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0256 0.0894
Trypanosoma brucei glucosidase, putative 0.0036 0.0256 0.8572
Schistosoma mansoni hypothetical protein 0.0014 0.004 0.0052
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0025 0.0144 0.4298
Schistosoma mansoni regulator of G protein signaling 0.002 0.0099 0.0135
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0025 0.0144 0.097
Onchocerca volvulus 0.0014 0.004 0.0184
Echinococcus granulosus ccaat enhancer binding protein delta 0.0011 0.0003 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0294 1
Echinococcus granulosus aminopeptidase N 0.0025 0.0144 0.0144
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0099 0.0099
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.039 0.1459
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0099 0.0099
Loa Loa (eye worm) aminopeptidase N 0.0025 0.0144 0.0539
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0144 0.0144
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0014 0.004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0369
Loa Loa (eye worm) hypothetical protein 0.002 0.0099 0.0369
Schistosoma mansoni microtubule-associated protein tau 0.073 0.7102 1
Onchocerca volvulus Glucosylceramidase homolog 0.0185 0.172 0.8564
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0035 0.0141
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0025 0.0144 0.0199
Mycobacterium tuberculosis Probable reductase 0.0091 0.0799 0.6607
Trichomonas vaginalis glucosylceramidase, putative 0.0281 0.2675 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0256 0.0894
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0099 0.0099
Brugia malayi von Willebrand factor type A domain containing protein 0.0014 0.004 0.0138

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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