Detailed information for compound 548728

Basic information

Technical information
  • TDR Targets ID: 548728
  • Name: [11-[3-(dimethylamino)-2-methyl-propyl]benzo[ b][1]benzazepin-8-yl] acetate
  • MW: 350.454 | Formula: C22H26N2O2
  • H donors: 0 H acceptors: 1 LogP: 4.68 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CC(CN1c2ccc(cc2C=Cc2c1cccc2)OC(=O)C)C)C
  • InChi: 1S/C22H26N2O2/c1-16(14-23(3)4)15-24-21-8-6-5-7-18(21)9-10-19-13-20(26-17(2)25)11-12-22(19)24/h5-13,16H,14-15H2,1-4H3
  • InChiKey: UQTXRYHGNLFLMF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • acetic acid [11-[3-(dimethylamino)-2-methylpropyl]-8-benzo[b][1]benzazepinyl] ester
  • [11-[3-(dimethylamino)-2-methyl-propyl]benzo[b][1]benzazepin-8-yl] ethanoate
  • acetic acid [11-[3-(dimethylamino)-2-methyl-propyl]benzo[b][1]benzazepin-8-yl] ester
  • [11-[3-(dimethylamino)-2-methylpropyl]benzo[b][1]benzazepin-8-yl] acetate
  • 10,11-dehydro-2-acetoxytrimipramine
  • [11-(3-dimethylamino-2-methylpropyl)benzo[b][1]benzazepin-8-yl] acetate
  • [11-(3-dimethylamino-2-methyl-propyl)benzo[b][1]benzazepin-8-yl] acetate
  • acetic acid [11-(3-dimethylamino-2-methylpropyl)-8-benzo[b][1]benzazepinyl] ester
  • acetic acid [11-(3-dimethylamino-2-methyl-propyl)benzo[b][1]benzazepin-8-yl] ester
  • [11-(3-dimethylamino-2-methyl-propyl)benzo[b][1]benzazepin-8-yl] ethanoate
  • 158798-74-4
  • 10,11-Dehydro-2-aco-tmp

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0067 0.0245 0.0245
Loa Loa (eye worm) PAN domain-containing protein 0.0092 0.0408 0.0417
Onchocerca volvulus 0.0092 0.0408 0.0417
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0318
Echinococcus multilocularis protein jagged 1 0.0067 0.0245 0.0464
Brugia malayi Kringle domain containing protein 0.0838 0.5273 0.5383
Mycobacterium tuberculosis Conserved protein 0.0077 0.0312 0.0888
Schistosoma mansoni laminin gamma-3 chain 0.0067 0.0245 0.0245
Mycobacterium tuberculosis Conserved protein 0.0077 0.0312 0.0888
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1338 0.9288
Brugia malayi Protein kinase domain containing protein 0.0838 0.5273 0.5383
Echinococcus granulosus slit 2 protein 0.0067 0.0245 0.0464
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0128 0.013
Schistosoma mansoni cercarial elastase (S01 family) 0.0311 0.1834 0.1834
Loa Loa (eye worm) hypothetical protein 0.1532 0.9797 1
Loa Loa (eye worm) hypothetical protein 0.0311 0.1834 0.1872
Brugia malayi PAN domain containing protein 0.0092 0.0408 0.0417
Toxoplasma gondii hypothetical protein 0.0092 0.0408 0.0775
Echinococcus granulosus glycoprotein Antigen 5 0.0311 0.1834 0.3478
Brugia malayi Calcium binding EGF domain containing protein 0.0067 0.0245 0.025
Echinococcus multilocularis fat cadherin tumor suppressor 0.0067 0.0245 0.0464
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0312 0.5
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Echinococcus granulosus delta-like protein 1 0.0067 0.0245 0.0464
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Brugia malayi PAN domain containing protein 0.0092 0.0408 0.0417
Brugia malayi notch-like transmembrane receptor 0.0067 0.0245 0.025
Echinococcus multilocularis Mastin 0.0311 0.1834 0.3478
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0197 0.1094 0.1116
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0877 0.5969
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0934 0.6383
Onchocerca volvulus Arrow homolog 0.0197 0.1094 0.1116
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0311 0.1834 0.1834
Loa Loa (eye worm) hypothetical protein 0.0077 0.0308 0.0314
Echinococcus granulosus tissue type plasminogen activator 0.0838 0.5273 1
Onchocerca volvulus 0.0067 0.0245 0.025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0716 0.0716
Loa Loa (eye worm) RNA binding protein 0.0068 0.0247 0.0252
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0128 0.013
Toxoplasma gondii microneme protein, putative 0.0092 0.0408 0.0775
Loa Loa (eye worm) hypothetical protein 0.0311 0.1834 0.1872
Loa Loa (eye worm) hypothetical protein 0.0311 0.1834 0.1872
Echinococcus granulosus laminin 0.0176 0.0954 0.1809
Echinococcus multilocularis fibrillin 1 0.0176 0.0954 0.1809
Leishmania major hypothetical protein, conserved 0.0838 0.5273 1
Schistosoma mansoni slit 0.0067 0.0245 0.0245
Echinococcus multilocularis neurogenic locus notch protein 4 0.0067 0.0245 0.0464
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0311 0.1834 0.3478
Schistosoma mansoni ap endonuclease 0.0037 0.0047 0.0047
Schistosoma mansoni notch 0.0067 0.0245 0.0245
Echinococcus multilocularis notch 0.0067 0.0245 0.0464
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0321 0.1897 0.1897
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Brugia malayi PAN domain containing protein 0.0092 0.0408 0.0417
Loa Loa (eye worm) hypothetical protein 0.1532 0.9797 1
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0312 0.711
Loa Loa (eye worm) hypothetical protein 0.0031 0.001 0.001
Brugia malayi EGF-like domain containing protein 0.0067 0.0245 0.025
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0247 0.0247
Schistosoma mansoni cercarial elastase (S01 family) 0.0311 0.1834 0.1834
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0047 0.0088
Schistosoma mansoni cercarial elastase (S01 family) 0.0311 0.1834 0.1834
Schistosoma mansoni hypothetical protein 0.0067 0.0245 0.0245
Brugia malayi beta-lactamase family protein 0.0077 0.0312 0.0318
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1437 1
Echinococcus multilocularis protein jagged 1 0.0067 0.0245 0.0464
Schistosoma mansoni hypothetical protein 0.0067 0.0245 0.0245
Mycobacterium ulcerans beta-lactamase 0.0077 0.0312 0.1483
Brugia malayi PAN domain containing protein 0.0092 0.0408 0.0417
Schistosoma mansoni notch 0.0067 0.0245 0.0245
Loa Loa (eye worm) transcription factor SMAD2 0.0232 0.1322 0.1349
Loa Loa (eye worm) hypothetical protein 0.0311 0.1834 0.1872
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Onchocerca volvulus 0.0092 0.0408 0.0417
Loa Loa (eye worm) MH2 domain-containing protein 0.0232 0.1322 0.1349
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.011 0.0457
Loa Loa (eye worm) hypothetical protein 0.0034 0.0026 0.0027
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0026 0.0027
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0495 0.3032 1
Toxoplasma gondii kringle domain-containing protein 0.0838 0.5273 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Echinococcus granulosus fibropellin Ia 0.0067 0.0245 0.0464
Schistosoma mansoni cercarial elastase (S01 family) 0.0311 0.1834 0.1834
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0312 0.1483
Echinococcus granulosus transmembrane protease serine 3 0.0311 0.1834 0.3478
Echinococcus multilocularis geminin 0.0168 0.0903 0.1712
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0419 0.0713
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1437 1
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0176 0.0954 0.0974
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1437 1
Schistosoma mansoni ap endonuclease 0.0037 0.0047 0.0047
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0312 0.0507
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0419 0.268
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0047 0.0048
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.0716 0.073
Mycobacterium leprae Probable lipase LipE 0.0077 0.0312 0.5
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0312 0.0888
Onchocerca volvulus 0.0092 0.0408 0.0417
Schistosoma mansoni hypothetical protein 0.0067 0.0245 0.0245
Toxoplasma gondii calcium binding egf domain-containing protein 0.0176 0.0954 0.1809
Schistosoma mansoni notch 0.0067 0.0245 0.0245
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0312 0.1906
Echinococcus multilocularis Tolloid protein 1 0.0186 0.1018 0.193
Onchocerca volvulus 0.0611 0.3791 0.3869
Loa Loa (eye worm) beta-lactamase 0.0077 0.0312 0.0318
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0877 0.5969
Schistosoma mansoni cercarial elastase (S01 family) 0.0311 0.1834 0.1834
Echinococcus granulosus notch 0.0067 0.0245 0.0464
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0312 0.1483
Schistosoma mansoni hypothetical protein 0.0311 0.1834 0.1834
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0312 0.0318
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0419 0.0713
Brugia malayi Trypsin family protein 0.1532 0.9797 1
Echinococcus multilocularis enteropeptidase 0.0311 0.1834 0.3478
Toxoplasma gondii PAN domain-containing protein 0.0092 0.0408 0.0775
Onchocerca volvulus 0.0092 0.0408 0.0417
Schistosoma mansoni hypothetical protein 0.0168 0.0903 0.0903
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0877 0.5969
Schistosoma mansoni septate junction protein 0.0067 0.0245 0.0245
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0716 0.1357
Onchocerca volvulus 0.0611 0.3791 0.3869
Schistosoma mansoni hypothetical protein 0.0067 0.0245 0.0245
Echinococcus multilocularis tissue type plasminogen activator 0.0838 0.5273 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0311 0.1834 0.1834
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0312 0.0888
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.025 0.1437 0.1467
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0247 0.0252
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0247 0.0247
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0247 0.0252
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0312 0.0888
Toxoplasma gondii subtilisin SUB12 0.0092 0.0408 0.0775
Brugia malayi EGF-like domain containing protein 0.0067 0.0245 0.025
Brugia malayi PAN domain containing protein 0.0092 0.0408 0.0417
Echinococcus multilocularis neurogenic locus protein delta 0.0067 0.0245 0.0464
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0186 0.1018 0.1039
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0877 0.5969
Schistosoma mansoni hypothetical protein 0.0067 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0318
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0312 0.0888
Mycobacterium tuberculosis Conserved protein 0.0077 0.0312 0.0888
Brugia malayi GCC2 and GCC3 family protein 0.0067 0.0245 0.025
Brugia malayi Calcium binding EGF domain containing protein 0.0077 0.0308 0.0314
Brugia malayi Calcium binding EGF domain containing protein 0.0067 0.0245 0.025
Brugia malayi MH2 domain containing protein 0.0232 0.1322 0.1349
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0419 0.0428
Onchocerca volvulus 0.0678 0.4228 0.4316
Loa Loa (eye worm) hypothetical protein 0.0092 0.0408 0.0417
Loa Loa (eye worm) hypothetical protein 0.0311 0.1834 0.1872
Echinococcus granulosus neurogenic locus notch protein 0.0067 0.0245 0.0464
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0092 0.0408 0.0775
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0312 0.1906
Brugia malayi beta-lactamase 0.0077 0.0312 0.0318
Onchocerca volvulus 0.0311 0.1834 0.1872
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0716 0.0716
Onchocerca volvulus 0.0311 0.1834 0.1872
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0312 0.0318
Onchocerca volvulus 0.0311 0.1834 0.1872
Schistosoma mansoni egf-like domain protein 0.0176 0.0954 0.0954
Onchocerca volvulus 0.0092 0.0408 0.0417
Onchocerca volvulus 0.0077 0.0312 0.0318
Brugia malayi PAN domain containing protein 0.0092 0.0408 0.0417
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0318
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Loa Loa (eye worm) hypothetical protein 0.0092 0.0408 0.0417
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.505 0.9576
Loa Loa (eye worm) hypothetical protein 0.0186 0.1018 0.1039
Onchocerca volvulus 0.0311 0.1834 0.1872
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0716 0.1357
Schistosoma mansoni kinase 0.0048 0.0118 0.0118
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0047 0.0048
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0047 0.5
Loa Loa (eye worm) notch protein 0.0067 0.0245 0.025
Onchocerca volvulus 0.0092 0.0408 0.0417
Echinococcus granulosus geminin 0.0168 0.0903 0.1712
Onchocerca volvulus 0.0092 0.0408 0.0417
Echinococcus multilocularis neurogenic locus notch protein 0.0067 0.0245 0.0464
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0312 0.0888
Mycobacterium ulcerans lipase LipD 0.0077 0.0312 0.1483
Schistosoma mansoni hypothetical protein 0.0311 0.1834 0.1834
Brugia malayi PAN domain containing protein 0.0092 0.0408 0.0417
Echinococcus multilocularis neural cadherin 0.0067 0.0245 0.0464
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0311 0.1834 0.1872
Brugia malayi CUB domain containing protein 0.0031 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0092 0.0408 0.0417
Onchocerca volvulus 0.0092 0.0408 0.0417
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1153 0.1176
Toxoplasma gondii PAN/Apple domain-containing protein 0.0092 0.0408 0.0775
Onchocerca volvulus 0.0235 0.1338 0.1366
Onchocerca volvulus 0.0838 0.5273 0.5383
Loa Loa (eye worm) TK/ROR protein kinase 0.0838 0.5273 0.5383
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.025 0.1437 0.1467
Trichomonas vaginalis esterase, putative 0.0077 0.0312 0.1906
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0419 0.0428
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1437 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0408 0.0417
Toxoplasma gondii calcium binding egf domain-containing protein 0.0176 0.0954 0.1809
Brugia malayi beta-lactamase family protein 0.0077 0.0312 0.0318
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Onchocerca volvulus Neurogenic locus notch homolog 0.0067 0.0245 0.025
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0311 0.1834 0.1834
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0934 0.6383
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Toxoplasma gondii PAN domain-containing protein 0.0092 0.0408 0.0775
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1437 1
Schistosoma mansoni notch 0.0067 0.0245 0.0245
Toxoplasma gondii PAN domain-containing protein 0.0253 0.1456 0.2761
Schistosoma mansoni cercarial elastase (S01 family) 0.0311 0.1834 0.1834
Schistosoma mansoni notch 0.0067 0.0245 0.0245
Brugia malayi Cadherin domain containing protein 0.0067 0.0245 0.025
Onchocerca volvulus 0.0077 0.0312 0.0318
Toxoplasma gondii PAN domain-containing protein 0.0253 0.1456 0.2761
Brugia malayi Muscle positioning protein 4 0.0678 0.4228 0.4316
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0877 0.5969
Schistosoma mansoni cercarial elastase (S01 family) 0.0311 0.1834 0.1834
Echinococcus multilocularis glycoprotein Antigen 5 0.0311 0.1834 0.3478
Loa Loa (eye worm) hypothetical protein 0.0197 0.1094 0.1116
Onchocerca volvulus 0.0067 0.0245 0.025
Leishmania major hypothetical protein, conserved 0.0077 0.0312 0.0507
Loa Loa (eye worm) hypothetical protein 0.0176 0.0954 0.0974
Echinococcus multilocularis slit 2 protein 0.0067 0.0245 0.0464
Brugia malayi Trypsin-like protease protein 5 0.0311 0.1834 0.1872
Brugia malayi Trypsin family protein 0.0311 0.1834 0.1872
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0247 0.0247
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0311 0.1834 0.1834
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0311 0.1834 0.1834
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Plasmodium falciparum cysteine repeat modular protein 1 0.0838 0.5273 1
Schistosoma mansoni hypothetical protein 0.0168 0.0903 0.0903
Brugia malayi RNA binding protein 0.0068 0.0247 0.0252
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0186 0.1018 0.1018
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0419 0.268
Echinococcus granulosus neural cadherin 0.0067 0.0245 0.0464
Toxoplasma gondii PAN domain-containing protein 0.0092 0.0408 0.0775
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0247 0.0469
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0312 0.0591
Toxoplasma gondii microneme protein MIC17B 0.0092 0.0408 0.0775
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0312 0.1906
Echinococcus granulosus protein jagged 1 0.0067 0.0245 0.0464
Loa Loa (eye worm) hypothetical protein 0.0092 0.0408 0.0417
Brugia malayi hypothetical protein 0.0311 0.1834 0.1872
Brugia malayi EGF-like domain containing protein 0.0067 0.0245 0.025
Brugia malayi Calcium binding EGF domain containing protein 0.0176 0.0954 0.0974
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0312 0.0888
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0877 0.5969
Schistosoma mansoni cell polarity protein 0.0067 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0318
Loa Loa (eye worm) hypothetical protein 0.0049 0.0128 0.013
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0312 0.0888
Brugia malayi EGF-like domain containing protein 0.0067 0.0245 0.025
Onchocerca volvulus 0.0092 0.0408 0.0417
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0419 0.0795
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0067 0.0245 0.025
Onchocerca volvulus 0.0092 0.0408 0.0417
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.0716 0.073
Onchocerca volvulus 0.0067 0.0245 0.025
Schistosoma mansoni hypothetical protein 0.0838 0.5273 0.5273
Echinococcus granulosus protein jagged 2 0.0067 0.0245 0.0464
Brugia malayi PAN domain containing protein 0.0092 0.0408 0.0417
Onchocerca volvulus 0.0077 0.0312 0.0318
Toxoplasma gondii PAN domain-containing protein 0.0092 0.0408 0.0775
Brugia malayi Trypsin family protein 0.0311 0.1834 0.1872
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1532 0.9797 0.9797
Brugia malayi Fibulin-1 precursor 0.0176 0.0954 0.0974
Toxoplasma gondii ABC1 family protein 0.0077 0.0312 0.0591
Brugia malayi TAR-binding protein 0.0068 0.0247 0.0252
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Toxoplasma gondii microneme protein MIC17A 0.0092 0.0408 0.0775
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.011 0.0457
Schistosoma mansoni hypothetical protein 0.0611 0.3791 0.3791
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0312 0.0507
Loa Loa (eye worm) PAN domain-containing protein 0.0092 0.0408 0.0417
Brugia malayi PAN domain containing protein 0.0092 0.0408 0.0417
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0419 0.268
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0047 0.0088
Echinococcus multilocularis fibropellin Ia 0.0067 0.0245 0.0464
Loa Loa (eye worm) PAN domain-containing protein 0.0092 0.0408 0.0417
Toxoplasma gondii hypothetical protein 0.0092 0.0408 0.0775
Brugia malayi Delta serrate ligand family protein 0.0067 0.0245 0.025
Loa Loa (eye worm) DOMON domain-containing protein 0.0611 0.3791 0.3869
Onchocerca volvulus Slit protein homolog 0.0067 0.0245 0.025
Toxoplasma gondii microneme protein MIC17C 0.0092 0.0408 0.0775
Loa Loa (eye worm) hypothetical protein 0.0207 0.1157 0.1181
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0877 0.5969
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Giardia lamblia Kinase, PLK 0.0094 0.0419 1
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0419 0.268
Loa Loa (eye worm) trypsin family protein 0.0311 0.1834 0.1872
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0311 0.1834 0.3478
Brugia malayi Pre-SET motif family protein 0.0206 0.1153 0.1176
Loa Loa (eye worm) PAN domain-containing protein 0.0092 0.0408 0.0417
Onchocerca volvulus 0.0067 0.0245 0.025
Echinococcus granulosus protein jagged 1 0.0067 0.0245 0.0464
Mycobacterium ulcerans hypothetical protein 0.0311 0.1834 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Loa Loa (eye worm) hypothetical protein 0.0176 0.0954 0.0974
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Echinococcus multilocularis neurogenic locus notch protein 0.0067 0.0245 0.0464
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0419 0.0795
Schistosoma mansoni cercarial elastase (S01 family) 0.0311 0.1834 0.1834
Brugia malayi EGF-like domain containing protein 0.0067 0.0245 0.025
Onchocerca volvulus 0.1221 0.777 0.7931
Schistosoma mansoni hypothetical protein 0.0067 0.0245 0.0245
Onchocerca volvulus Putative cubilin 0.0077 0.0308 0.0314
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0047 0.0088
Onchocerca volvulus 0.1532 0.9797 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0312 0.0591
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0877 0.0895
Loa Loa (eye worm) hypothetical protein 0.0838 0.5273 0.5383
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Echinococcus granulosus protein jagged 2 0.0067 0.0245 0.0464
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0716 0.1357
Echinococcus granulosus neurogenic locus protein delta 0.0067 0.0245 0.0464
Schistosoma mansoni cercarial elastase (S01 family) 0.0311 0.1834 0.1834
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0067 0.0245 0.0245
Brugia malayi Cadherin domain containing protein 0.0067 0.0245 0.025
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0419 1
Onchocerca volvulus 0.0092 0.0408 0.0417
Echinococcus multilocularis protein jagged 2 0.0067 0.0245 0.0464
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0312 0.0591
Loa Loa (eye worm) Notch2 0.0067 0.0245 0.025
Loa Loa (eye worm) hypothetical protein 0.0067 0.0245 0.025
Schistosoma mansoni hypothetical protein 0.0034 0.0026 0.0026
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0067 0.0245 0.025
Echinococcus granulosus Mastin 0.0311 0.1834 0.3478
Brugia malayi EGF-like domain containing protein 0.0067 0.0245 0.025
Echinococcus granulosus Tolloid protein 1 0.0186 0.1018 0.193
Echinococcus multilocularis laminin 0.0176 0.0954 0.1809
Loa Loa (eye worm) hypothetical protein 0.0678 0.4228 0.4316
Loa Loa (eye worm) hypothetical protein 0.0092 0.0408 0.0417
Loa Loa (eye worm) PAN domain-containing protein 0.0092 0.0408 0.0417
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0716 0.0716
Loa Loa (eye worm) hypothetical protein 0.0092 0.0408 0.0417
Onchocerca volvulus 0.0611 0.3791 0.3869
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0312 0.1906
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0047 0.5
Echinococcus multilocularis neurogenic locus protein delta 0.0067 0.0245 0.0464
Echinococcus multilocularis transmembrane protease serine 3 0.0311 0.1834 0.3478
Trypanosoma cruzi hypothetical protein, conserved 0.0838 0.5273 1
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0197 0.1094 0.1116
Brugia malayi EGF-like domain containing protein 0.0067 0.0245 0.025
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0311 0.1834 0.3478
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0419 0.268
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0716 0.1357
Echinococcus granulosus enteropeptidase 0.0311 0.1834 0.3478
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0247 0.0252
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0611 0.3791 0.3869
Toxoplasma gondii EGF family domain-containing protein 0.0067 0.0245 0.0464
Onchocerca volvulus 0.0611 0.3791 0.3869
Schistosoma mansoni notch 0.0067 0.0245 0.0245
Brugia malayi PAN domain containing protein 0.0092 0.0408 0.0417
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0312 0.1906
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0419 0.0419
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0838 0.5273 1
Brugia malayi Trypsin family protein 0.0311 0.1834 0.1872
Trypanosoma brucei polo-like protein kinase 0.0094 0.0419 1
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1437 1
Mycobacterium ulcerans hypothetical protein 0.0077 0.0312 0.1483
Toxoplasma gondii exonuclease III APE 0.0037 0.0047 0.0088
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0419 0.0713
Toxoplasma gondii microneme protein MIC4 0.0092 0.0408 0.0775
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0318
Echinococcus granulosus neurogenic locus notch protein 0.0067 0.0245 0.0464
Echinococcus granulosus neurogenic locus notch protein 4 0.0067 0.0245 0.0464
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0311 0.1834 0.3478
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0247 0.0247
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0247 0.0247
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0419 0.268
Loa Loa (eye worm) hypothetical protein 0.0077 0.0312 0.0318
Schistosoma mansoni cercarial elastase (S01 family) 0.0311 0.1834 0.1834
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0312 0.0312
Giardia lamblia High cysteine protein 0.0067 0.0245 0.5313
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0419 0.0428
Brugia malayi SEA domain containing protein 0.0611 0.3791 0.3869
Echinococcus granulosus tar DNA binding protein 0.0068 0.0247 0.0469
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0419 0.268
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0311 0.1834 0.1834
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0128 0.013
Onchocerca volvulus 0.0311 0.1834 0.1872

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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