Detailed information for compound 551176

Basic information

Technical information
  • TDR Targets ID: 551176
  • Name: 4-methoxy-2-(5-methoxy-3-methyl-pyrazol-1-yl) -6-methyl-pyrimidine
  • MW: 234.254 | Formula: C11H14N4O2
  • H donors: 0 H acceptors: 3 LogP: 1.92 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(C)nc(n1)n1nc(cc1OC)C
  • InChi: 1S/C11H14N4O2/c1-7-5-9(16-3)13-11(12-7)15-10(17-4)6-8(2)14-15/h5-6H,1-4H3
  • InChiKey: RHAXSHUQNIEUEY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-methoxy-2-(5-methoxy-3-methyl-1-pyrazolyl)-6-methylpyrimidine
  • 4-methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine
  • Epirizole
  • 18694-40-1
  • BPBio1_000137
  • CAS-18694-40-1
  • M9017_SIGMA
  • Prestwick_201
  • 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole
  • 2-(3-Methoxy-5-methylpyrazol-2-yl)-4-methoxy-6-methylpyrimidine
  • 2-(3-Methyl-5-methoxy-1-pyrazolyl)-4-methoxy-6-methylpyrimidine
  • 4-Methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methylpyrimidine
  • 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidin [German]
  • 5-25-18-00012 (Beilstein Handbook Reference)
  • BRN 0751084
  • DA-398
  • EINECS 242-507-1
  • Epirizol [INN-Spanish]
  • Epirizole [USAN:INN:JAN]
  • Epirizolum [INN-Latin]
  • Mebron
  • Mepirizol [German]
  • Mepirizole
  • Pyrimidine, 4-methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methyl-
  • NCGC00016737-01
  • Prestwick1_000032
  • BSPBio_000123
  • ZINC00057412
  • Prestwick3_000032
  • Prestwick0_000032
  • D01394
  • Epirizole (JP15/USAN)
  • Mebron (TN)
  • MLS000028844
  • SMR000058715
  • SPBio_002044
  • Prestwick2_000032

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens androgen receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0556 0.2761
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0556 0.8588
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0144 0.0143
Echinococcus multilocularis solute carrier family 22 0.0014 0.0209 0.0207
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.035 0.0349
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0209 0.3212
Loa Loa (eye worm) hypothetical protein 0.0011 0.0144 0.0713
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0268 0.133
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.059
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0209 0.1038
Brugia malayi Sugar transporter family protein 0.0103 0.201 1
Onchocerca volvulus 0.0014 0.0209 0.1771
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0209 0.5451
Schistosoma mansoni glucose transport protein 0.0103 0.201 0.2009
Onchocerca volvulus Putative transporter 0.0014 0.0209 0.1771
Schistosoma mansoni sugar transporter 0.0014 0.0209 0.0207
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.035 0.4585
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0647 0.1107
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0543 0.0542
Echinococcus multilocularis geminin 0.0205 0.4092 0.4092
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0647 1
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0014 0.0209 0.6691
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0006 0.0032 0.0031
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0543 0.0542
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0209 0.1038
Leishmania major hypothetical protein, conserved 0.0005 0.0018 0.0262
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.012 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.035 0.4585
Onchocerca volvulus 0.0014 0.0209 0.1771
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0556 0.0597
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.009 0.0089
Trypanosoma brucei glucose transporter, putative 0.0032 0.0564 0.8715
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0543 0.0542
Leishmania major glucose transporter, lmgt3 0.0032 0.0564 0.8715
Plasmodium vivax hexose transporter 0.0103 0.201 0.2253
Brugia malayi nuclear receptor RXR 0.001 0.012 0.059
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Loa Loa (eye worm) hypothetical protein 0.0031 0.0556 0.2761
Loa Loa (eye worm) hypothetical protein 0.0011 0.0144 0.0713
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0556 0.0555
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0556 0.2761
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0564 0.8715
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.201 0.2009
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.012 0.059
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.0136 0.3543
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0543 0.27
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.059
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0543 1
Brugia malayi hypothetical protein 0.0014 0.0209 0.1033
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0209 0.1033
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.173 0.1729
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.035 0.1737
Brugia malayi Sugar transporter family protein 0.0014 0.0209 0.1033
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0006 0.0032 0.0566
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.012 0.059
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0382 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Brugia malayi Death domain containing protein 0.0017 0.0268 0.133
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.035 0.0349
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0006 0.0032 0.0053
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0006 0.0032 0.0805
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Echinococcus granulosus synaptic vesicle 2 protein 0.0014 0.0209 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.035 0.1737
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.059
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.037
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0382 0.1895
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Echinococcus granulosus General substrate transporter 0.0088 0.1715 0.1714
Loa Loa (eye worm) hypothetical protein 0.0018 0.0271 0.1345
Loa Loa (eye worm) hypothetical protein 0.0014 0.0209 0.1033
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.012 0.059
Onchocerca volvulus 0.0014 0.0209 0.1771
Brugia malayi Sugar transporter family protein 0.0014 0.0209 0.1033
Trypanosoma brucei glucose transporter, putative 0.0032 0.0564 0.8715
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.3301 0.3724
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0006 0.0032 0.0989
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0556 0.0597
Schistosoma mansoni nuclear hormone receptor 0.0021 0.035 0.0349
Schistosoma mansoni thyroid hormone receptor 0.0021 0.035 0.0349
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0209 0.0356
Schistosoma mansoni hypothetical protein 0.0494 1 1
Schistosoma mansoni hypothetical protein 0.0205 0.4092 0.4092
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0647 0.0701
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.037
Schistosoma mansoni nuclear hormone receptor 0.001 0.012 0.0118
Trypanosoma brucei glucose transporter 1E 0.0032 0.0564 0.8715
Toxoplasma gondii sugar transporter ST2 0.0014 0.0209 0.0356
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0647 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.037
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0014 0.0209 0.6691
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0209 0.0201
Echinococcus multilocularis solute carrier family 22 0.0014 0.0209 0.0207
Schistosoma mansoni cpg binding protein 0.0037 0.0662 0.0661
Leishmania major glucose transporter, lmgt2 0.0032 0.0564 0.8715
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.201 0.2009
Echinococcus granulosus geminin 0.0205 0.4092 0.4092
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0074 0.037
Schistosoma mansoni sugar transporter 0.0014 0.0209 0.0207
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1256 0.215
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.035 0.1737
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Loa Loa (eye worm) hypothetical protein 0.0014 0.0209 0.1033
Trypanosoma brucei glucose transporter 2A 0.0032 0.0564 0.8715
Mycobacterium ulcerans hypothetical protein 0.0005 0.0018 0.0445
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.035 0.0349
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.035 0.0349
Brugia malayi hypothetical protein 0.001 0.012 0.059
Schistosoma mansoni coup transcription factor 0.0021 0.035 0.0349
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0268 0.2961
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0268 0.0267
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0556 0.0555
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0564 0.2806
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0564 0.8715
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.201 0.2009
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.012 0.0118
Giardia lamblia Hexose transporter 0.0014 0.0209 0.346
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.012 0.059
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.013 0.0642
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0564 0.2806
Schistosoma mansoni protein kinase 0.0031 0.0556 0.0555
Brugia malayi Nuclear hormone receptor E75 0.001 0.012 0.059
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0209 0.5451
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0133 0.0132
Brugia malayi conserved hypotetical protein 0.001 0.012 0.059
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.035 0.0349
Schistosoma mansoni hypothetical protein 0.0103 0.201 0.2009
Brugia malayi nuclear receptor NHR-67 0.001 0.012 0.059
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.0018 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.037
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0382 0.7027
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0136 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0382 0.1899
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0006 0.0032 0.0153
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.035 0.1737
Loa Loa (eye worm) hypothetical protein 0.0017 0.0268 0.133
Trypanosoma brucei glucose transporter, putative 0.0032 0.0564 0.8715
Schistosoma mansoni protein kinase 0.0031 0.0556 0.0555
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.035 0.0349
Schistosoma mansoni nuclear hormone receptor 0.001 0.012 0.0118
Loa Loa (eye worm) hypothetical protein 0.0014 0.0209 0.1033
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.059
Entamoeba histolytica protein kinase, putative 0.0031 0.0556 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0144 0.0713
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0543 1
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0382 0.5894
Brugia malayi nuclear hormone receptor 0.001 0.012 0.059
Schistosoma mansoni glycyl-tRNA synthetase 0.0006 0.0032 0.0031
Mycobacterium tuberculosis Conserved hypothetical protein 0.0005 0.0018 0.0546
Schistosoma mansoni glucose transporter 0.0014 0.0209 0.0207
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0382 0.0381
Loa Loa (eye worm) hypothetical protein 0.0014 0.0209 0.1033
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.012 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0543 0.9752
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0311 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0144 0.0143
Giardia lamblia Sugar-proton symporter 0.0014 0.0209 0.346
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.012 0.059
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0556 0.0555
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0382 0.6849
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.059
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0018 0.009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.035 0.1737
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0018 0.009
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.035 0.1737
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0144 0.0143
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0543 0.0542
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0006 0.0032 0.0153
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.012 0.059
Brugia malayi nuclear receptor NHR-88 0.001 0.012 0.059
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0014 0.0209 0.0207
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0564 0.2806
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.059
Echinococcus granulosus solute carrier family 22 0.0014 0.0209 0.0207
Toxoplasma gondii sugar transporter ST1 0.0014 0.0209 0.0356
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.035 0.1737
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0209 0.1033
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0647 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.035 0.0349
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0268 0.133
Trypanosoma cruzi hypothetical protein, conserved 0.0005 0.0018 0.0262
Loa Loa (eye worm) hypothetical protein 0.0021 0.035 0.1737
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.201 0.2009
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0564 0.2806
Loa Loa (eye worm) hypothetical protein 0.0006 0.0032 0.0153
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0556 0.0555
Brugia malayi hypothetical protein 0.001 0.012 0.059
Echinococcus multilocularis solute carrier family 22 0.0014 0.0209 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0005 0.0018 0.009
Schistosoma mansoni protein kinase 0.0031 0.0556 0.0555
Loa Loa (eye worm) hypothetical protein 0.0014 0.0209 0.1033
Brugia malayi Nuclear hormone receptor E75 0.001 0.012 0.059
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.009 0.0089
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.035 0.0349
Echinococcus granulosus FTZ F1 alpha 0.0021 0.035 0.0349
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0382 0.5894
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0018 0.0271 0.027
Echinococcus granulosus Threonyl tRNA synthetase C 0.0006 0.0032 0.0031
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.035 0.0349
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0543 0.2696
Leishmania major glucose transporter, lmgt1 0.0032 0.0564 0.8715
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.035 0.1737
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0564 0.8715
Echinococcus granulosus solute carrier family 22 0.0014 0.0209 0.0207
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0647 1
Brugia malayi Cam kinase protein 1 0.0031 0.0556 0.2761
Loa Loa (eye worm) hypothetical protein 0.0021 0.035 0.1737
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.035 0.0349
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0006 0.0032 0.0158
Loa Loa (eye worm) hypothetical protein 0.0014 0.0209 0.1033
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0269 0.4151
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.059
Loa Loa (eye worm) hypothetical protein 0.0011 0.0144 0.0713
Toxoplasma gondii glycyl-tRNA synthetase 0.0006 0.0032 0.0053
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0311 0.5725
Echinococcus multilocularis General substrate transporter 0.0088 0.1715 0.1714
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0209 0.1038
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.037
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0005 0.0018 0.0262
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0556 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0556 0.0555
Echinococcus granulosus solute carrier family 22 0.0014 0.0209 0.0207
Loa Loa (eye worm) hypothetical protein 0.0014 0.0209 0.1033
Trypanosoma brucei sugar transporter, putative 0.0014 0.0209 0.3212
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0382 0.0381
Echinococcus granulosus glycyl tRNA synthetase 0.0006 0.0032 0.0031
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.035 0.0349
Onchocerca volvulus 0.0014 0.0209 0.1771
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0006 0.0032 0.0475
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0209 0.5451
Onchocerca volvulus 0.0035 0.0622 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.035 0.1737
Trypanosoma brucei glucose transporter, putative 0.0032 0.0564 0.8715
Schistosoma mansoni nuclear receptor 0.001 0.012 0.0118
Echinococcus granulosus death domain containing protein 0.0017 0.0268 0.0267
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0074 0.037
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.012 0.0118
Onchocerca volvulus 0.0014 0.0209 0.1771
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0005 0.0018 0.0262
Brugia malayi nuclear receptor NHR-88 0.0021 0.035 0.1737
Onchocerca volvulus 0.0014 0.0209 0.1771
Loa Loa (eye worm) hypothetical protein 0.0014 0.0209 0.1033
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0647 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Plasmodium falciparum hexose transporter 0.0103 0.201 0.2253
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.035 0.1737
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0622 0.3091
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0556 0.2761
Loa Loa (eye worm) hypothetical protein 0.0014 0.0209 0.1033
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0564 0.8715
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0074 0.037
Brugia malayi nuclear hormone receptor 0.0021 0.035 0.1737
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.035 0.0349
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.035 0.1737
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0.0209 1
Trichomonas vaginalis helicase, putative 0.0008 0.0074 0.037
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0209 0.1038
Entamoeba histolytica hypothetical protein 0.0023 0.0382 0.6679
Loa Loa (eye worm) hypothetical protein 0.0021 0.035 0.1737
Echinococcus multilocularis Ankyrin 0.0018 0.0271 0.027
Loa Loa (eye worm) hypothetical protein 0.0031 0.0543 0.2696
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0382 0.0399
Loa Loa (eye worm) hypothetical protein 0.0014 0.0209 0.1033
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0133 0.0132
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0564 0.2806
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.035 0.1737
Mycobacterium leprae conserved hypothetical protein 0.0005 0.0018 0.0313
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0209 0.3212
Plasmodium vivax CDK-related protein kinase 6, putative 0.0436 0.881 1
Schistosoma mansoni cpg binding protein 0.0035 0.0622 0.0621
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0556 0.0951
Echinococcus multilocularis cpg binding protein 0.0037 0.0662 0.0661
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.035 0.0349
Onchocerca volvulus 0.0014 0.0209 0.1771
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0209 0.1038
Schistosoma mansoni glucose transport protein 0.0103 0.201 0.2009
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0209 0.1033
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0382 0.0381
Onchocerca volvulus 0.0014 0.0209 0.1771
Leishmania major threonyl-tRNA synthetase, putative 0.0006 0.0032 0.0475
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.059
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0209 0.3212
Loa Loa (eye worm) hypothetical protein 0.0014 0.0209 0.1033
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0311 1
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0006 0.0032 0.0153
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0074 0.037
Trypanosoma cruzi hexose transporter 0.0032 0.0564 0.8715
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Brugia malayi ecdysone receptor 0.001 0.012 0.059
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0516 0.0515
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0556 0.0597
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0005 0.0018 0.0262
Echinococcus granulosus Sugar transporter ERD6 protein 0.0014 0.0209 0.0207
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1416 0.1415
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0006 0.0032 0.0475
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0564 0.2806
Loa Loa (eye worm) hypothetical protein 0.0014 0.0209 0.1033
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0382 0.0381
Schistosoma mansoni cpg binding protein 0.0037 0.0662 0.0661
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.035 0.1737
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.035 0.1737
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0172 0.0851
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.012 0.0118
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.035 0.1737
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0556 0.0597
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0133 0.0656
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.173 0.1729
Loa Loa (eye worm) hypothetical protein 0.0014 0.0209 0.1033
Loa Loa (eye worm) hypothetical protein 0.0025 0.0425 0.2109
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0074 0.037
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.035 0.1737
Loa Loa (eye worm) sugar transporter 0.0014 0.0209 0.1033
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0556 0.0555
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.035 0.0349
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.012 0.0118
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.0136 0.2978
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0382 0.0652
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.201 0.2009
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.035 0.0349
Onchocerca volvulus 0.0014 0.0209 0.1771
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0144 0.0713
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0324 0.1612
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.012 0.0118
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0564 0.8715
Loa Loa (eye worm) hypothetical protein 0.0014 0.0209 0.1033
Toxoplasma gondii protein kinase, putative 0.029 0.5836 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.201 0.2009
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0556 0.0555
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Loa Loa (eye worm) hypothetical protein 0.0021 0.035 0.1737
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.035 0.1737
Schistosoma mansoni sugar transporter 0.0014 0.0209 0.0207
Loa Loa (eye worm) hypothetical protein 0.0021 0.035 0.1737
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0015 0.0014
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.201 0.2009
Loa Loa (eye worm) hypothetical protein 0.0021 0.035 0.1737
Schistosoma mansoni hypothetical protein 0.0205 0.4092 0.4092
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.012 0.0118
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.012 0.0118
Echinococcus granulosus cpg binding protein 0.0037 0.0662 0.0661
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0032 0.0475
Mycobacterium ulcerans sugar transporter 0.0014 0.0209 0.5451
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0382 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.012 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.035 0.1737
Plasmodium falciparum protein kinase 6 0.0436 0.881 1
Toxoplasma gondii sugar transporter ST3 0.0014 0.0209 0.0356
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0556 0.0597
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0014 0.0209 0.3212
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.037
Brugia malayi major facilitator superfamily protein 0.0014 0.0209 0.1033
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0005 0.0018 0.0029
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0209 0.1033
Brugia malayi nuclear receptor RXR 0.0011 0.0144 0.0713
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0209 0.1038
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.035 0.0349
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0564 0.2806
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0074 0.037
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0209 0.3212
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0006 0.0032 0.0805
Echinococcus multilocularis glycyl tRNA synthetase 0.0006 0.0032 0.0031
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.035 0.0349
Loa Loa (eye worm) hypothetical protein 0.0031 0.0543 0.2696
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.035 0.0349
Loa Loa (eye worm) hypothetical protein 0.0014 0.0209 0.1033
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.059
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0556 0.0555
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0543 0.2696
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0556 0.2765
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.035 0.0349
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.201 0.2009
Onchocerca volvulus 0.0014 0.0209 0.1771
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.035 0.0349
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0556 0.0951
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0556 0.0597
Schistosoma mansoni nuclear receptor 0.001 0.012 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.035 0.1737
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.035 0.1737
Echinococcus multilocularis solute carrier family 22 0.0014 0.0209 0.0207
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0268 0.0267
Schistosoma mansoni glucose transport protein 0.0103 0.201 0.2009
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.012 0.0118
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0382 0.5894
Brugia malayi tailless protein 0.001 0.012 0.059
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.012 0.059
Loa Loa (eye worm) hypothetical protein 0.0011 0.0144 0.0713
Loa Loa (eye worm) hypothetical protein 0.0021 0.035 0.1737
Trypanosoma brucei glucose transporter, putative 0.0032 0.0564 0.8715
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0382 0.0399
Brugia malayi steroid hormone receptor 0.0021 0.035 0.1737
Onchocerca volvulus 0.0014 0.0209 0.1771
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0647 0.0701
Brugia malayi ecdysteroid receptor 0.0021 0.035 0.1737
Onchocerca volvulus 0.0014 0.0209 0.1771
Brugia malayi CXXC zinc finger family protein 0.0035 0.0622 0.3091
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.012 0.0118
Loa Loa (eye worm) hypothetical protein 0.0023 0.0382 0.1895
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.059
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.009 0.0089
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Brugia malayi Major Facilitator Superfamily protein 0.0014 0.0209 0.1033
Echinococcus granulosus solute carrier family 22 0.0014 0.0209 0.0207
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0556 0.0597
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.035 0.1737
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0268 0.0267
Brugia malayi hypothetical protein 0.0014 0.0209 0.1033
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0556 0.0951
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0556 0.0555
Brugia malayi hypothetical protein 0.0011 0.0144 0.0713
Echinococcus multilocularis synaptic vesicle 2 protein 0.0014 0.0209 0.0207
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0074 0.037
Brugia malayi Protein kinase domain containing protein 0.0019 0.0308 0.153
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.035 0.0349
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.035 0.0349
Schistosoma mansoni zinc finger protein 0.001 0.012 0.0118
Leishmania major protein kinase, putative 0.0031 0.0556 0.8588
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.059
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0564 0.8715
Loa Loa (eye worm) hypothetical protein 0.0021 0.035 0.1737
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0144 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.201 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.035 0.1737
Schistosoma mansoni thyroid hormone receptor 0.0021 0.035 0.0349
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0006 0.0032 0.0153
Brugia malayi glycyl-tRNA synthetase 0.0006 0.0032 0.0153
Onchocerca volvulus 0.0014 0.0209 0.1771
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.012 0.0118
Schistosoma mansoni netrin receptor unc5 0.0017 0.0268 0.0267
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.3301 0.3724
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0268 0.0267
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.035 0.4585
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0144 0.0713
Trypanosoma brucei glucose transporter, putative 0.0032 0.0564 0.8715
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.201 0.3443
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.037
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0268 0.0267
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.009 0.0089
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.035 0.0349
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0209 0.1038
Brugia malayi major facilitator superfamily protein 0.0014 0.0209 0.1033
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.3301 0.5655
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0556 0.0597
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0516 0.0515
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.009 0.0089
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0032 0.0475
Loa Loa (eye worm) hypothetical protein 0.0011 0.0144 0.0713
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.037
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0014 0.0209 0.0207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.035 0.1737
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.035 0.0349
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.035 0.0349
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.012 0.0118
Schistosoma mansoni hypothetical protein 0.0017 0.0268 0.0267
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.012 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.035 0.1737
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0209 0.1038
Leishmania major hypothetical protein, conserved 0.0014 0.0209 0.3212
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0074 0.037
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0382 1
Loa Loa (eye worm) hypothetical protein 0.001 0.012 0.059
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0074 0.037
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Plasmodium falciparum protein kinase 7 0.029 0.5836 0.6612
Echinococcus granulosus Ankyrin 0.0018 0.0271 0.027
Onchocerca volvulus 0.0014 0.0209 0.1771
Entamoeba histolytica protein kinase, putative 0.0031 0.0556 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0564 0.8715
Brugia malayi hypothetical protein 0.0014 0.0209 0.1033
Trypanosoma brucei glucose transporter, putative 0.0032 0.0564 0.8715
Brugia malayi hypothetical protein 0.0011 0.0144 0.0713
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0209 0.1038
Loa Loa (eye worm) DR-78 0.001 0.012 0.059
Onchocerca volvulus 0.0021 0.035 0.4585
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0564 0.8715
Onchocerca volvulus 0.0014 0.0209 0.1771
Onchocerca volvulus 0.0014 0.0209 0.1771
Brugia malayi Uncoordinated protein 44 0.0017 0.0268 0.133
Leishmania major hypothetical protein, conserved 0.0005 0.0018 0.0262
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.035 0.0349
Plasmodium vivax sugar transporter, putative 0.0014 0.0209 0.0201
Loa Loa (eye worm) sugar transporter 0.0103 0.201 1
Schistosoma mansoni sugar transporter 0.0014 0.0209 0.0207

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 5.011872336 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 0.0007 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0517 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2593 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 9.9597 um PUBCHEM_BIOASSAY: Concentration response confirmation assay for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) [Related pubchem assays: 2551 (Primary screen tested at 6 concentrations from 46 uM to 3 nM)] ChEMBL. No reference
Potency (functional) 11.4554 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.7083 uM PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 35.3385 um PUBCHEM_BIOASSAY: Concentration response confirmation VP16 counterscreen for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) [Related pubchem assays: 2546 (Primary counterscreen tested in the VP16 cell line at 6 concentrations from 46 uM to 3 nM)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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