Detailed information for compound 556075

Basic information

Technical information
  • TDR Targets ID: 556075
  • Name: 2-(2-isopropenyl-1-methyl-cyclobutyl)ethanol
  • MW: 154.249 | Formula: C10H18O
  • H donors: 1 H acceptors: 1 LogP: 2.93 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1(CCO)CCC1C(=C)C
  • InChi: 1S/C10H18O/c1-8(2)9-4-5-10(9,3)6-7-11/h9,11H,1,4-7H2,2-3H3
  • InChiKey: SJKPJXGGNKMRPD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-isopropenyl-1-methylcyclobutyl)ethanol
  • 2-(1-methyl-2-prop-1-en-2-yl-cyclobutyl)ethanol
  • 2-(1-methyl-2-prop-1-en-2-ylcyclobutyl)ethanol
  • grandisol
  • 26532-22-9
  • (1R-cis)-1-Methyl-2-(1-methylethenyl)cyclobutaneethanol
  • Caswell No. 471AB
  • Cyclobutaneethanol, 1-methyl-2-(1-methylethenyl)-, (1R,2S)-
  • Cyclobutaneethanol, 1-methyl-2-(1-methylethenyl)-, (1R-cis)-
  • Cyclobutaneethanol, 2-isopropenyl-1-methyl-, cis-( )-
  • Grandlure I
  • EPA Pesticide Chemical Code 112401
  • ( )-cis-2-Isopropenyl-1-methylcyclobutaneethanol
  • (+)-Gandisol
  • Cyclobutaneethanol, 2-isopropenyl-1-methyl-, cis-(+)-
  • Cyclobutaneethanol, 1-methyl-2-(1-methylethenyl)-, trans-
  • Cyclobutaneethanol, 2-isopropenyl-1-methyl-, stereoisomer
  • Cyclobutaneethanol, 1-methyl-2-(1-methylethenyl)-, cis-
  • Cyclobutaneethanol, 1-methyl-2-1-methylethenyl;-, Z;-
  • (1R-Z)-1-Methyl-2-(1-methylethenyl)cyclobutaneethanol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0111 0.4725
Onchocerca volvulus 0.0034 0.0033 0.0575
Loa Loa (eye worm) fibroinase 0.0034 0.0033 0.0278
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0008 0.0081
Leishmania major cathepsin L-like protease 0.0034 0.0033 0.1176
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0111 0.0183
Loa Loa (eye worm) hypothetical protein 0.0025 0.0015 0.0082
Onchocerca volvulus 0.003 0.0026 0.0421
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0226 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0026 0.0204
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0153 0.0275 0.0473
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0033 0.1472
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0011 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0026 0.0026
Brugia malayi Probable ClpP-like protease 0.0153 0.0275 0.2952
Mycobacterium ulcerans transcriptional regulator 0.2807 0.5662 1
Loa Loa (eye worm) ctsf protein 0.0034 0.0033 0.0278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0026 0.0026
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.0113 0.0193 1
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0109 0.019
Loa Loa (eye worm) hypothetical protein 0.0072 0.0111 0.1119
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0111 0.0183
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0111 0.5737
Loa Loa (eye worm) hypothetical protein 0.0071 0.0109 0.1102
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0033 0.0575
Entamoeba histolytica hypothetical protein 0.0113 0.0193 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0153 0.0275 1
Echinococcus granulosus survival motor neuron protein 1 0.0476 0.0931 0.0931
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0008 0.0335
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0008 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0226 1
Plasmodium vivax vivapain-2 0.0034 0.0033 0.1211
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0111 0.5737
Entamoeba histolytica hypothetical protein 0.0113 0.0193 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0008 0.0335
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0015 0.055
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0033 0.0278
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.01 0.0168 0.0294
Plasmodium vivax SET domain protein, putative 0.003 0.0026 0.096
Echinococcus multilocularis peptidase Clp (S14 family) 0.01 0.0168 0.0168
Loa Loa (eye worm) cysteine protease 0.0034 0.0033 0.0278
Schistosoma mansoni hypothetical protein 0.004 0.0047 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0226 1
Echinococcus multilocularis microtubule associated protein 2 0.4943 1 1
Mycobacterium ulcerans TetR family transcriptional regulator 0.2807 0.5662 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0008 0.0081
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0111 0.0183
Leishmania major cathepsin L-like protease 0.0034 0.0033 0.1176
Echinococcus granulosus cathepsin l1 0.0023 0.0011 0.0011
Leishmania major hypothetical protein, conserved 0.0025 0.0015 0.0345
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0053 0.0072 0.0113
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0033 0.1176
Loa Loa (eye worm) hypothetical protein 0.0042 0.005 0.0457
Echinococcus multilocularis survival motor neuron protein 1 0.0476 0.0931 0.0931
Onchocerca volvulus 0.0034 0.0033 0.0575
Loa Loa (eye worm) hypothetical protein 0.0071 0.0109 0.1102
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0111 0.5737
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.0395 0.4196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0732
Schistosoma mansoni hypothetical protein 0.004 0.0047 0.0047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0226 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0226 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0455 0.0889 0.1568
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0008 0.0011
Mycobacterium tuberculosis Conserved protein 0.0071 0.0109 0.019
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0111 0.4725
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0226 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0732
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0109 0.1102
Trichomonas vaginalis esterase, putative 0.0071 0.0109 0.2405
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0111 0.0183
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0008 0.0167
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0074 0.0117
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0015 0.0282
Schistosoma mansoni hypothetical protein 0.0113 0.0193 0.0193
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0068 0.0117
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0074 0.2689
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0732
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0033 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0109 0.2405
Echinococcus multilocularis protein dispatched 1 0.0048 0.0062 0.0062
Entamoeba histolytica cysteine protease, putative 0.0034 0.0033 0.1722
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.01 0.0168 0.0294
Leishmania major cathepsin L-like protease 0.0129 0.0226 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0101 0.017 0.7525
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0109 0.019
Toxoplasma gondii hypothetical protein 0.0053 0.0072 0.2392
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.0193 0.0193
Onchocerca volvulus 0.0197 0.0364 0.7965
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0732
Echinococcus granulosus Protein patched homolog 1 0.0042 0.005 0.005
Leishmania major cathepsin L-like protease 0.0034 0.0033 0.1176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0732
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0033 0.0033
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0008 0.0167
Onchocerca volvulus 0.0034 0.0033 0.0575
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0072 0.0111 0.1119
Mycobacterium leprae Probable lipase LipE 0.0071 0.0109 0.018
Onchocerca volvulus 0.0072 0.0111 0.2311
Onchocerca volvulus 0.0241 0.0455 1
Echinococcus multilocularis tumor protein p63 0.1343 0.2691 0.2691
Echinococcus multilocularis expressed conserved protein 0.0092 0.0151 0.0151
Toxoplasma gondii cathepsin CPL 0.0034 0.0033 0.0962
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0111 0.0193
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0068 0.0117
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0053 0.0072 0.2602
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0163 0.1752
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0033 0.0732
Onchocerca volvulus 0.0034 0.0033 0.0575
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0011 0.0011
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0248 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.005 0.1096
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0015 0.055
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0008 0.0335
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.005 0.0457
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0109 0.2405
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.005 0.005
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0008 0.0392
Schistosoma mansoni cellular tumor antigen P53 0.0197 0.0364 0.0364
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0111 0.4725
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0153 0.0275 1
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0109 0.4833
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0163 0.8438
Schistosoma mansoni hypothetical protein 0.004 0.0047 0.0047
Brugia malayi CHE-14 protein 0.0042 0.005 0.0535
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0109 0.2405
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0109 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0226 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0109 0.018
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0033 0.1211
Schistosoma mansoni microtubule-associated protein tau 0.4943 1 1
Onchocerca volvulus 0.0034 0.0033 0.0575
Trypanosoma cruzi cysteine peptidase, putative 0.0129 0.0226 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0111 0.0183
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0153 0.0275 0.5
Echinococcus granulosus cathepsin l1 0.0034 0.0033 0.0033
Leishmania major hypothetical protein, conserved 0.0071 0.0109 0.4654
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0071 0.0109 0.1102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0732
Plasmodium vivax vivapain-2 0.0034 0.0033 0.1211
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0008 0.0276
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0033 0.0033
Mycobacterium tuberculosis Conserved protein 0.0071 0.0109 0.019
Mycobacterium tuberculosis Conserved protein 0.0071 0.0109 0.019
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0732
Onchocerca volvulus 0.0034 0.0033 0.0575
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0109 0.4833
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0033 0.1211
Mycobacterium ulcerans hypothetical protein 0.0072 0.0111 0.0183
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0015 0.0668
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0732
Brugia malayi Cathepsin L-like precursor 0.0034 0.0033 0.0358
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0008 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0732
Trypanosoma cruzi cruzipain precursor, putative 0.0129 0.0226 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1605 0.3224 0.3224
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0033 0.1211
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0111 0.1191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0011 0.0233
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0153 0.0275 0.0275
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0109 0.019
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0008 0.0011
Leishmania major cathepsin L-like protease 0.0034 0.0033 0.1176
Loa Loa (eye worm) hypothetical protein 0.0054 0.0074 0.0718
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0074 0.2689
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0153 0.0275 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0163 0.1684
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0008 0.0081
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2807 0.5662 1
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0033 0.1722
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0732
Loa Loa (eye worm) hypothetical protein 0.0071 0.0109 0.1102
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0068 0.0117
Brugia malayi Cathepsin L-like precursor 0.0034 0.0033 0.0358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0732
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0008 0.0011
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0033 0.0033
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0109 0.019
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0476 0.0931 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0054 0.0074 0.0718
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0111 0.0183
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.0193 0.0193
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0226 1
Onchocerca volvulus 0.0071 0.0109 0.2276
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0109 0.2405
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0008 0.0011
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0109 0.3977
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0072 0.0111 0.1119
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0033 0.0033
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0153 0.0275 0.0473
Mycobacterium ulcerans beta-lactamase 0.0071 0.0109 0.018
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0015 0.0668
Loa Loa (eye worm) hypothetical protein 0.0054 0.0074 0.0718
Loa Loa (eye worm) hypothetical protein 0.0054 0.0074 0.0718
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0026 0.0026
Brugia malayi hypothetical protein 0.0476 0.0931 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0153 0.0275 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0226 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0109 0.0109
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0026 0.0703
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0163 0.0163
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0166 0.0166
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0153 0.0275 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.01 0.0168 0.0284
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0111 0.0183
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0033
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0033 0.0033
Loa Loa (eye worm) beta-lactamase 0.0071 0.0109 0.1102
Onchocerca volvulus 0.0097 0.0162 0.345
Loa Loa (eye worm) hypothetical protein 0.0153 0.0275 0.2894
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0109 0.0109
Onchocerca volvulus 0.0023 0.0011 0.0068
Schistosoma mansoni survival motor neuron protein 0.0097 0.0162 0.0162
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0226 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0162 0.1737
Brugia malayi Cathepsin L-like precursor 0.0023 0.0011 0.0114
Brugia malayi cathepsin L-like precursor 0.0023 0.0011 0.0114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0732
Loa Loa (eye worm) hypothetical protein 0.0071 0.0109 0.1102
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0033 0.0358
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0008 0.0081
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0109 0.2405
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0033 0.1722
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0008 0.0008
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0011 0.0548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0226 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0732
Echinococcus granulosus expressed conserved protein 0.0092 0.0151 0.0151
Mycobacterium ulcerans lipase LipD 0.0071 0.0109 0.018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0068 0.0117
Schistosoma mansoni patched 1 0.0042 0.005 0.005
Brugia malayi beta-lactamase 0.0071 0.0109 0.1174
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0033
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.005 0.005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0011 0.0233
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0033 0.0575
Leishmania major cathepsin L-like protease 0.0034 0.0033 0.1176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0732
Loa Loa (eye worm) hypothetical protein 0.0071 0.0109 0.1102
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0008 0.0081
Brugia malayi beta-lactamase family protein 0.0071 0.0109 0.1174
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0732
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0053 0.0072 0.2602
Schistosoma mansoni hypothetical protein 0.0097 0.0162 0.0162
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0111 0.0183
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0732
Loa Loa (eye worm) hypothetical protein 0.0054 0.0074 0.0718
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0008 0.0335
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0732
Onchocerca volvulus 0.0034 0.0033 0.0575
Schistosoma mansoni hypothetical protein 0.004 0.0047 0.0047
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0163 0.0163
Mycobacterium ulcerans hypothetical protein 0.0071 0.0109 0.018
Trichomonas vaginalis set domain proteins, putative 0.0241 0.0455 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0033 0.0732
Echinococcus multilocularis cysteine protease 0.0034 0.0033 0.0033
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0153 0.0275 1
Brugia malayi hypothetical protein 0.0025 0.0015 0.0162
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0015 0.055
Echinococcus granulosus peptidase Clp S14 family 0.01 0.0168 0.0168
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0026 0.0026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0732
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0153 0.0275 0.0473
Brugia malayi beta-lactamase family protein 0.0071 0.0109 0.1174
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0109 0.019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.0193 0.0193
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0109 0.018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0732
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0226 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0129 0.0226 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0008 0.0335
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0732
Leishmania major cathepsin L-like protease 0.0129 0.0226 1
Onchocerca volvulus 0.0071 0.0109 0.2276
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0153 0.0275 1
Echinococcus multilocularis cysteine protease 0.0034 0.0033 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0033 0.0732
Onchocerca volvulus 0.0071 0.0109 0.2276
Brugia malayi Cathepsin L-like precursor 0.0034 0.0033 0.0358
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0033 0.0575
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0008 0.0335
Brugia malayi hypothetical protein 0.0113 0.0193 0.2076
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0026 0.0026
Brugia malayi Cathepsin L-like precursor 0.0034 0.0033 0.0358
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0074 0.0128
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0109 0.1174
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0111 0.0193
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0109 0.4833
Echinococcus granulosus tumor protein p63 0.1343 0.2691 0.2691
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0109 0.019
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2807 0.5662 1
Brugia malayi Cathepsin L-like precursor 0.0034 0.0033 0.0358
Brugia malayi Cathepsin L-like precursor 0.0034 0.0033 0.0358
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2807 0.5662 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0011 0.0033
Schistosoma mansoni peptidase Clp (S14 family) 0.0153 0.0275 0.0275
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0109 0.018
Brugia malayi Pre-SET motif family protein 0.003 0.0026 0.0283
Leishmania major cathepsin L-like protease 0.0129 0.0226 1
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0008 0.0276
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0109 0.0109
Brugia malayi Cathepsin L-like precursor 0.0023 0.0011 0.0114
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0111 0.1191
Brugia malayi Pre-SET motif family protein 0.0212 0.0395 0.4243
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0033 0.0732
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0118 0.0204 0.8997
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0033 0.0278
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0109 0.019
Loa Loa (eye worm) hypothetical protein 0.0051 0.0069 0.0665
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0153 0.0275 0.0275
Entamoeba histolytica hypothetical protein 0.0113 0.0193 1
Loa Loa (eye worm) hypothetical protein 0.0197 0.0364 0.3855
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0015 0.0668
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0111 0.1191
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0111 0.0183
Loa Loa (eye worm) hypothetical protein 0.0034 0.0033 0.0278
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0008 0.0011
Toxoplasma gondii ABC1 family protein 0.0071 0.0109 0.3807
Echinococcus multilocularis protein patched 0.0042 0.005 0.005
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0033 0.0033
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0008 0.0011
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0248 0.0248
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0008 0.0011

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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