Detailed information for compound 563963

Basic information

Technical information
  • TDR Targets ID: 563963
  • Name: [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dih ydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-p hosphoryl] [5-(7,8-dimethyl-4-oxo-2-thioxo-be nzo[g]pteridin-10-yl)-2,3,4-trihydroxy-pentyl ] hydrogen phosphate
  • MW: 801.615 | Formula: C27H33N9O14P2S
  • H donors: 9 H acceptors: 13 LogP: -4.35 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC(C(C(Cn1c2cc(C)c(cc2nc2c1nc(=S)[nH]c2=O)C)O)O)COP(=O)(OP(=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N)O)O
  • InChi: 1S/C27H33N9O14P2S/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(53)33-24)5-14(37)19(39)15(38)6-47-51(43,44)50-52(45,46)48-7-16-20(40)21(41)26(49-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,43,44)(H,45,46)(H2,28,29,30)(H,34,42,53)/t14?,15?,16-,19?,20-,21-,26-/m1/s1
  • InChiKey: CXZGKQFPEIKTLU-KUIMXZBMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-2-tetrahydrofuranyl]methoxy-hydroxyphosphoryl] [5-(7,8-dimethyl-4-oxo-2-thioxo-10-benzo[g]pteridinyl)-2,3,4-trihydroxypentyl] hydrogen phosphate
  • [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] [5-(7,8-dimethyl-4-oxo-2-sulfanylidene-benzo[g]pteridin-10-yl)-2,3,4-trihydroxy-pentyl] hydrogen phosphate
  • [[(2R,3S,4R,5R)-5-adenin-9-yl-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] [2,3,4-trihydroxy-5-(4-keto-7,8-dimethyl-2-thioxo-benzo[g]pteridin-10-yl)pentyl] hydrogen phosphate
  • [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [5-(7,8-dimethyl-4-oxo-2-sulfanylidenebenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl] hydrogen phosphate
  • 2-thio-FAD
  • [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[5-(7,8-dimethyl-4-oxo-2-sulfanylidenebenzo[g]pteridin-10-yl)-2,3,4-trihydroxypentoxy]-hydroxyphosphoryl] hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [[5-(7,8-dimethyl-4-oxo-2-thioxo-benzo[g]pteridin-10-yl)-2,3,4-trihydroxy-pentoxy]-hydroxy-phosphoryl] hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(6-amino-9-purinyl)-3,4-dihydroxy-2-tetrahydrofuranyl]methyl [[5-(7,8-dimethyl-4-oxo-2-thioxo-10-benzo[g]pteridinyl)-2,3,4-trihydroxypentoxy]-hydroxyphosphoryl] hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methyl [hydroxy-[2,3,4-trihydroxy-5-(4-keto-7,8-dimethyl-2-thioxo-benzo[g]pteridin-10-yl)pentoxy]phosphoryl] hydrogen phosphate
  • [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [[5-(7,8-dimethyl-4-oxo-2-sulfanylidene-benzo[g]pteridin-10-yl)-2,3,4-trihydroxy-pentoxy]-hydroxy-phosphoryl] hydrogen phosphate
  • 43203-75-4
  • Riboflavin-5'-(trihydrogen diphosphate), 2-thio-, 5'-5'-ester with adenosine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.3332 0.6795 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.052 0.1002 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.028 0.0508 0.0505
Schistosoma mansoni hypothetical protein 0.004 0.0014 0.0014
Echinococcus granulosus thioredoxin glutathione reductase 0.0042 0.0018 0.0014
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.017 0.0166
Brugia malayi Glycosyl hydrolases family 31 protein 0.052 0.1002 0.1002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0037 0.0033
Brugia malayi PHD-finger family protein 0.0085 0.0107 0.0107
Loa Loa (eye worm) jmjC domain-containing protein 0.0176 0.0295 0.0292
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0077 0.009 0.0087
Echinococcus granulosus histone lysine methyltransferase setb 0.0145 0.023 0.0227
Loa Loa (eye worm) hypothetical protein 0.0903 0.1793 0.179
Echinococcus granulosus chromobox protein 1 0.0136 0.0211 0.0208
Echinococcus multilocularis lysosomal alpha glucosidase 0.4887 1 1
Trichomonas vaginalis alpha-L-fucosidase, putative 0.1244 0.2493 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.058 0.1126 0.4509
Schistosoma mansoni jumonji/arid domain-containing protein 0.0103 0.0144 0.0146
Brugia malayi jmjC domain containing protein 0.028 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0076 0.0088 0.0085
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0094 0.0125 0.2381
Brugia malayi hypothetical protein 0.0062 0.0059 0.0059
Plasmodium vivax glutathione reductase, putative 0.0041 0.0016 0.0263
Mycobacterium ulcerans glutaminase 0.0274 0.0497 0.0515
Loa Loa (eye worm) hypothetical protein 0.0062 0.0059 0.0056
Loa Loa (eye worm) glutaminase 0.0274 0.0497 0.0494
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.052 0.1002 0.4012
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.017 0.0166
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0145 0.023 0.0227
Echinococcus granulosus jumonji domain containing protein 0.0119 0.0176 0.0173
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0283 0.0515 0.0534
Echinococcus multilocularis geminin 0.017 0.0282 0.0279
Onchocerca volvulus 0.0179 0.0301 0.0438
Mycobacterium tuberculosis Probable dehydrogenase 0.0094 0.0125 0.2381
Echinococcus multilocularis neutral alpha glucosidase AB 0.052 0.1002 0.0999
Schistosoma mansoni hypothetical protein 0.0166 0.0274 0.0276
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0283 0.0515 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0016 0.0255
Schistosoma mansoni hypothetical protein 0.0077 0.009 0.0091
Trichomonas vaginalis glucosylceramidase, putative 0.0081 0.0097 0.0378
Schistosoma mansoni chromobox protein 0.0136 0.0211 0.0213
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.058 0.1126 0.4509
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0088 0.0341
Echinococcus multilocularis chromobox protein 1 0.0136 0.0211 0.0208
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0476 0.0912 0.8076
Onchocerca volvulus Glucosylceramidase homolog 0.0081 0.0097 0.0139
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0146 0.0233 0.023
Trichomonas vaginalis glucosylceramidase, putative 0.0123 0.0184 0.0727
Brugia malayi Pre-SET motif family protein 0.0145 0.023 0.023
Echinococcus multilocularis lysosomal alpha glucosidase 0.4887 1 1
Giardia lamblia Fructose-bisphosphate aldolase 0.058 0.1126 1
Loa Loa (eye worm) heterochromatin protein 1 0.0136 0.0211 0.0208
Brugia malayi beta-lactamase family protein 0.0035 0.0003 0.0003
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0476 0.0912 0.91
Trypanosoma brucei glycosyl hydrolase-like protein 0.0476 0.0912 0.91
Echinococcus granulosus geminin 0.017 0.0282 0.0279
Schistosoma mansoni hypothetical protein 0.0085 0.0107 0.0108
Trichomonas vaginalis glucosylceramidase, putative 0.0123 0.0184 0.0727
Loa Loa (eye worm) TRE-1 protein 0.0179 0.0301 0.0297
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.058 0.1126 0.4509
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0016 0.0263
Loa Loa (eye worm) hypothetical protein 0.0179 0.0301 0.0297
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0082 0.01 0.0143
Trichomonas vaginalis alpha-glucosidase, putative 0.052 0.1002 0.4012
Trichomonas vaginalis glucosylceramidase, putative 0.0081 0.0097 0.0378
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0105 0.0147 0.2804
Trichomonas vaginalis alpha-glucosidase, putative 0.052 0.1002 0.4012
Trichomonas vaginalis alpha-glucosidase, putative 0.0476 0.0912 0.365
Onchocerca volvulus 0.0179 0.0301 0.0438
Trichomonas vaginalis glucosylceramidase, putative 0.0081 0.0097 0.0378
Schistosoma mansoni hypothetical protein 0.0077 0.009 0.0091
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0476 0.0912 0.91
Loa Loa (eye worm) hypothetical protein 0.0476 0.0912 0.0909
Trichomonas vaginalis glutaminase, putative 0.0274 0.0497 0.1982
Trypanosoma cruzi glycosyl hydrolase, putative 0.0087 0.0111 0.1073
Brugia malayi Trehalase family protein 0.0179 0.0301 0.0301
Schistosoma mansoni hypothetical protein 0.017 0.0282 0.0285
Toxoplasma gondii PHD-finger domain-containing protein 0.0085 0.0107 0.1042
Trichomonas vaginalis glucosylceramidase, putative 0.0085 0.0106 0.0414
Echinococcus granulosus neutral alpha glucosidase AB 0.052 0.1002 0.0999
Brugia malayi Pre-SET motif family protein 0.1011 0.2014 0.2014
Plasmodium vivax hypothetical protein, conserved 0.0276 0.05 1
Schistosoma mansoni chromobox protein 0.0136 0.0211 0.0213
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0003 0.0003
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.0391 0.7568
Schistosoma mansoni beta-galactosidase 0.0903 0.1793 0.1809
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0016 0.0131
Schistosoma mansoni glutaminase 0.0274 0.0497 0.0501
Trichomonas vaginalis glucosylceramidase, putative 0.0123 0.0184 0.0727
Brugia malayi trehalase 0.0062 0.0059 0.0059
Loa Loa (eye worm) trehalase 0.0179 0.0301 0.0297
Trichomonas vaginalis glucosylceramidase, putative 0.0081 0.0097 0.0378
Loa Loa (eye worm) hypothetical protein 0.0117 0.0173 0.017
Loa Loa (eye worm) hypothetical protein 0.006 0.0054 0.0051
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0094 0.0125 0.2381
Brugia malayi hypothetical protein 0.0179 0.0301 0.0301
Loa Loa (eye worm) alpha-L-fucosidase 0.2835 0.5771 0.577
Echinococcus granulosus lysosomal alpha glucosidase 0.4887 1 1
Mycobacterium leprae Possible hydrolase 0.0087 0.0111 0.2093
Loa Loa (eye worm) glutathione reductase 0.0041 0.0016 0.0013
Mycobacterium tuberculosis Probable oxidoreductase 0.0105 0.0147 0.2804
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.052 0.1002 0.8885
Trichomonas vaginalis set domain proteins, putative 0.115 0.2301 0.9228
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0037 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0179 0.0301 0.1194
Brugia malayi Thioredoxin reductase 0.0041 0.0016 0.0016
Brugia malayi Trehalase family protein 0.0062 0.0059 0.0059
Trichomonas vaginalis chromobox protein, putative 0.0136 0.0211 0.0835
Loa Loa (eye worm) PHD-finger family protein 0.0085 0.0107 0.0104
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1011 0.2014 0.2011
Trichomonas vaginalis chromobox protein, putative 0.0082 0.01 0.0389
Trypanosoma cruzi hypothetical protein, conserved 0.052 0.1002 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0094 0.0125 0.2381
Loa Loa (eye worm) hypothetical protein 0.0145 0.023 0.0227
Loa Loa (eye worm) hypothetical protein 0.0179 0.0301 0.0297
Brugia malayi Calcitonin receptor-like protein seb-1 0.0243 0.0433 0.0433
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0476 0.0912 0.365
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0283 0.0515 1
Trichomonas vaginalis glucosylceramidase, putative 0.0123 0.0184 0.0727
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0037 0.0037
Brugia malayi trehalase I 0.0062 0.0059 0.0059
Trichomonas vaginalis glucosylceramidase, putative 0.0085 0.0106 0.0414
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.052 0.1002 0.0999
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0276 0.05 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0476 0.0912 0.365
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0077 0.009 0.0087
Loa Loa (eye worm) hypothetical protein 0.0077 0.009 0.0087
Trichomonas vaginalis maltase-glucoamylase, putative 0.052 0.1002 0.4012
Loa Loa (eye worm) trehalase 0.0062 0.0059 0.0056
Trichomonas vaginalis sucrase-isomaltase, putative 0.052 0.1002 0.4012
Trypanosoma brucei trypanothione reductase 0.0041 0.0016 0.0131
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.028 0.0508 0.0505
Echinococcus granulosus fucosidase alpha L 1 tissue 0.4688 0.9589 0.9589
Echinococcus multilocularis peregrin 0.0085 0.0107 0.0104
Brugia malayi MH2 domain containing protein 0.0116 0.017 0.017
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0476 0.0912 0.365
Schistosoma mansoni alpha-glucosidase 0.4844 0.991 1
Echinococcus multilocularis beta galactosidase 0.0903 0.1793 0.179
Echinococcus granulosus chromobox protein 1 0.0136 0.0211 0.0208
Loa Loa (eye worm) hypothetical protein 0.0243 0.0433 0.0429
Loa Loa (eye worm) hypothetical protein 0.0179 0.0301 0.0297
Brugia malayi Latrophilin receptor protein 2 0.0077 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0062 0.0059 0.0056
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0167 0.0276 0.0278
Plasmodium falciparum phd finger protein, putative 0.0085 0.0107 0.1881
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.052 0.1002 0.4012
Brugia malayi Glycosyl hydrolases family 31 protein 0.0476 0.0912 0.0912
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0043 0.0157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0037 0.0033
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0105 0.0147 0.2804
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0243 0.0433 0.0433
Loa Loa (eye worm) trehalase 0.0179 0.0301 0.0297
Trichomonas vaginalis alpha-glucosidase, putative 0.0476 0.0912 0.365
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0476 0.0912 0.1338
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0037 0.0037
Schistosoma mansoni alpha-glucosidase 0.4844 0.991 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0476 0.0912 0.365
Echinococcus multilocularis lysine specific demethylase 5A 0.0103 0.0144 0.0141
Onchocerca volvulus 0.006 0.0054 0.0075
Schistosoma mansoni hypothetical protein 0.017 0.0282 0.0285
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0085 0.0107 0.0108
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0076 0.0088 0.0125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.058 0.1126 0.4509
Trypanosoma brucei glucosidase, putative 0.052 0.1002 1
Trichomonas vaginalis glucosylceramidase, putative 0.0081 0.0097 0.0378
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0037 0.0033
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.058 0.1126 0.4509
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.4887 1 1
Leishmania major trypanothione reductase 0.0041 0.0016 0.0131
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0077 0.009 0.0091
Loa Loa (eye worm) hypothetical protein 0.0166 0.0274 0.0271
Loa Loa (eye worm) glutaminase 2 0.0274 0.0497 0.0494
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0014 0.0011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0077 0.009 0.0087
Trichomonas vaginalis alpha-glucosidase, putative 0.052 0.1002 0.4012
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0094 0.0125 0.2381
Loa Loa (eye worm) hypothetical protein 0.0085 0.0107 0.0104
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0243 0.0433 0.0429
Schistosoma mansoni jumonji domain containing protein 0.0222 0.0389 0.0393
Schistosoma mansoni hypothetical protein 0.0077 0.009 0.0091
Brugia malayi Serotonin receptor 0.0487 0.0934 0.0934
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.058 0.1126 1
Brugia malayi Trehalase protein 5 0.0062 0.0059 0.0059
Echinococcus granulosus peregrin 0.0085 0.0107 0.0104
Trichomonas vaginalis alpha-L-fucosidase, putative 0.1244 0.2493 1
Brugia malayi Bromodomain containing protein 0.0085 0.0107 0.0107
Plasmodium vivax hypothetical protein, conserved 0.0085 0.0107 0.2095
Onchocerca volvulus 0.0167 0.0276 0.0401
Trypanosoma brucei glycosyl hydrolase, putative 0.0087 0.0111 0.1073
Brugia malayi beta-lactamase 0.0035 0.0003 0.0003
Treponema pallidum fructose-bisphosphate aldolase 0.058 0.1126 1
Toxoplasma gondii thioredoxin reductase 0.0041 0.0016 0.0131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0145 0.023 0.0232
Trichomonas vaginalis trehalase, putative 0.0179 0.0301 0.1194
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0037 0.0033
Brugia malayi hypothetical protein 0.004 0.0014 0.0014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0077 0.009 0.009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.058 0.1126 0.4509
Onchocerca volvulus 0.0179 0.0301 0.0438
Trypanosoma cruzi hypothetical protein, conserved 0.052 0.1002 1
Brugia malayi latrophilin 2 splice variant baaae 0.0166 0.0274 0.0274
Brugia malayi Heterochromatin protein 1 0.0136 0.0211 0.0211
Echinococcus multilocularis jumonji domain containing protein 0.0119 0.0176 0.0173
Loa Loa (eye worm) trehalase 0.0179 0.0301 0.0297
Onchocerca volvulus Trehalase homolog 0.0179 0.0301 0.0438
Echinococcus multilocularis fucosidase, alpha L 1, tissue 0.4688 0.9589 0.9589
Loa Loa (eye worm) hypothetical protein 0.0179 0.0301 0.0297
Plasmodium vivax SET domain protein, putative 0.0145 0.023 0.4564
Echinococcus multilocularis thioredoxin glutathione reductase 0.0042 0.0018 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0081 0.0097 0.0378
Trichomonas vaginalis alpha-glucosidase, putative 0.0476 0.0912 0.365
Loa Loa (eye worm) TRE-2 protein 0.0179 0.0301 0.0297
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.058 0.1126 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0003 0.0003
Onchocerca volvulus 0.0179 0.0301 0.0438
Brugia malayi hypothetical protein 0.0062 0.0059 0.0059
Trichomonas vaginalis alpha-glucosidase, putative 0.052 0.1002 0.4012
Loa Loa (eye worm) hypothetical protein 0.0062 0.0059 0.0056
Loa Loa (eye worm) hypothetical protein 0.0179 0.0301 0.0297
Trichomonas vaginalis alpha-glucosidase, putative 0.0476 0.0912 0.365
Echinococcus multilocularis chromobox protein 1 0.0136 0.0211 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0088 0.0341
Echinococcus granulosus beta galactosidase 0.0903 0.1793 0.179
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0123 0.0184 0.0184
Echinococcus granulosus lysine specific demethylase 5A 0.0103 0.0144 0.0141
Echinococcus multilocularis PHD finger protein rhinoceros 0.0085 0.0107 0.0104
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0145 0.023 0.0232
Brugia malayi Trehalase family protein 0.0179 0.0301 0.0301
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0037 0.0033
Echinococcus granulosus PHD finger protein rhinoceros 0.0085 0.0107 0.0104
Brugia malayi Alpha-L-fucosidase family protein 0.2835 0.5771 0.5771
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.058 0.1126 0.4509
Echinococcus granulosus hypothetical protein 0.0726 0.1428 0.1425
Onchocerca volvulus 0.115 0.2301 0.3383
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0105 0.0147 0.2804
Brugia malayi chromobox protein homolog 3 0.0076 0.0088 0.0088
Loa Loa (eye worm) latrophilin receptor protein 2 0.0077 0.009 0.0087
Leishmania major glycosyl hydrolase-like protein 0.0476 0.0912 0.91
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0145 0.023 0.227
Brugia malayi Trehalase family protein 0.0179 0.0301 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0043 0.0157
Mycobacterium ulcerans glycosyl hydrolase 0.0087 0.0111 0.0112
Mycobacterium tuberculosis Probable reductase 0.0094 0.0125 0.2381
Schistosoma mansoni alpha-l-fucosidase 0.2835 0.5771 0.5823
Brugia malayi Trehalase family protein 0.0179 0.0301 0.0301
Schistosoma mansoni alpha glucosidase 0.052 0.1002 0.1011
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.014 0.0219 0.0216
Leishmania major alpha glucosidase II subunit, putative 0.052 0.1002 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0103 0.0144 0.0141
Echinococcus multilocularis GPCR, family 2 0.0077 0.009 0.0087
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0145 0.023 0.0232
Brugia malayi hypothetical protein 0.0062 0.0059 0.0059
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0145 0.023 0.0227
Toxoplasma gondii PHD-finger domain-containing protein 0.0085 0.0107 0.1042
Trichomonas vaginalis glucosylceramidase, putative 0.0123 0.0184 0.0727
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.058 0.1126 0.4509
Mycobacterium tuberculosis Conserved protein 0.0087 0.0111 0.2093
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0016 0.0013
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0014 0.0014
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0014 0.0011
Brugia malayi glutaminase DH11.1 0.0274 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0062 0.0059 0.0056
Onchocerca volvulus 0.0179 0.0301 0.0438
Brugia malayi beta-lactamase family protein 0.0035 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0903 0.1793 0.179
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0123 0.0184 0.0181
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0077 0.009 0.0087
Schistosoma mansoni jumonji/arid domain-containing protein 0.0103 0.0144 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0123 0.0184 0.0727
Loa Loa (eye worm) trehalase 0.0062 0.0059 0.0056
Trichomonas vaginalis alpha-glucosidase, putative 0.052 0.1002 0.4012
Onchocerca volvulus Alhambra homolog 0.0085 0.0107 0.0153
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0094 0.0125 0.2381
Leishmania major glycosyl hydrolase, putative 0.0087 0.0111 0.1073
Echinococcus granulosus GPCR family 2 0.0077 0.009 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.0081 0.0097 0.0378
Mycobacterium ulcerans alpha-L-fucosidase 0.4688 0.9589 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.052 0.1002 0.8885
Brugia malayi Trehalase family protein 0.0062 0.0059 0.0059
Echinococcus multilocularis conserved hypothetical protein 0.0719 0.1412 0.1409
Trichomonas vaginalis chromobox protein, putative 0.0082 0.01 0.0389
Brugia malayi jmjC domain containing protein 0.0103 0.0144 0.0144
Brugia malayi glutathione reductase 0.0041 0.0016 0.0016
Trichomonas vaginalis chromobox protein, putative 0.0136 0.0211 0.0835

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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