Detailed information for compound 566410

Basic information

Technical information
  • TDR Targets ID: 566410
  • Name: (3Z)-2-(2,2-diphenylacetyl)-3-hydrazono-indan -1-one
  • MW: 354.401 | Formula: C23H18N2O2
  • H donors: 1 H acceptors: 2 LogP: 4.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NN=C1c2ccccc2C(=O)C1C(=O)C(c1ccccc1)c1ccccc1
  • InChi: 1S/C23H18N2O2/c24-25-21-17-13-7-8-14-18(17)22(26)20(21)23(27)19(15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14,19-20H,24H2/b25-21+
  • InChiKey: QBGMRRUHCFHZLC-NJNXFGOHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3Z)-3-hydrazono-2-(1-oxo-2,2-diphenylethyl)-1-indanone
  • (3Z)-2-(2,2-diphenylethanoyl)-3-hydrazinylidene-inden-1-one
  • (3Z)-2-(2,2-diphenylacetyl)-3-hydrazinylideneinden-1-one
  • difezon
  • (3Z)-2-[2,2-di(phenyl)acetyl]-3-hydrazinylideneinden-1-one
  • 2-[2,2-di(phenyl)acetyl]-3-hydrazinylideneinden-1-one
  • (3Z)-2-[2,2-di(phenyl)acetyl]-3-hydrazono-indan-1-one
  • 2-[2,2-di(phenyl)acetyl]-3-hydrazono-indan-1-one
  • (3Z)-3-hydrazono-2-[1-oxo-2,2-di(phenyl)ethyl]-1-indanone
  • 3-hydrazono-2-[1-oxo-2,2-di(phenyl)ethyl]-1-indanone
  • (3Z)-2-[2,2-di(phenyl)ethanoyl]-3-hydrazinylidene-inden-1-one
  • 2-[2,2-di(phenyl)ethanoyl]-3-hydrazinylidene-inden-1-one
  • SBB008710
  • Oprea1_270238
  • ICCB1_000124
  • 1,3-Indandione, 2-(diphenylacetyl)-, 1-hydrazone (8CI)
  • 1H-Indene-1,3(2H)-dione, 2-(diphenylacetyl)-, 1-hydrazone (9CI)
  • 2-(Diphenylacetyl)-1H-indene-1,3(2H)-dione 1-hydrazone
  • D204838_ALDRICH
  • EINECS 225-821-3
  • NSC 83445
  • NCIOpen2_008988

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0079 0.0799 0.194
Schistosoma mansoni survival motor neuron protein 0.0054 0.0519 0.0507
Schistosoma mansoni ets-related 0.0013 0.0053 0.004
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0607 0.0587
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0465 0.0969
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0106 0.0216
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0128 0.027
Trypanosoma brucei unspecified product 0.0042 0.0376 0.3132
Entamoeba histolytica hypothetical protein 0.0035 0.0306 0.201
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0465 0.3976
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0053 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0465 0.3976
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0179 0.04
Onchocerca volvulus 0.0079 0.0799 0.194
Brugia malayi Ets-domain containing protein 0.0087 0.0888 0.2186
Onchocerca volvulus 0.0079 0.0799 0.194
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0031 0.001
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0345 0.3763 0.6738
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0619 0.1508
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1459 0.1441
Brugia malayi beta-lactamase family protein 0.0079 0.0799 0.1961
Brugia malayi MH2 domain containing protein 0.0144 0.1522 0.3783
Loa Loa (eye worm) hypothetical protein 0.0079 0.0799 0.1961
Toxoplasma gondii exonuclease III APE 0.0019 0.0128 0.0792
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0128 0.0044
Loa Loa (eye worm) hypothetical protein 0.0267 0.289 0.7228
Loa Loa (eye worm) hypothetical protein 0.0079 0.0799 0.1961
Treponema pallidum hypothetical protein 0.0345 0.3763 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0179 0.0186
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0128 0.0107
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0031 0.001
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0607 0.0595
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0087 0.0066
Echinococcus granulosus protein C ets 2 0.0013 0.0053 0.0032
Echinococcus granulosus survival motor neuron protein 1 0.0267 0.289 0.2875
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0031 0.001
Schistosoma mansoni smad1 5 8 and 0.001 0.0021 0.0008
Echinococcus granulosus tar DNA binding protein 0.0062 0.0607 0.0587
Brugia malayi CXXC zinc finger family protein 0.0063 0.0619 0.1508
Trypanosoma brucei polo-like protein kinase 0.0106 0.1101 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0195 0.1418
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0021 0.0008
Brugia malayi hypothetical protein 0.0011 0.0031 0.0026
Schistosoma mansoni dep domain containing protein 0.0011 0.0031 0.0018
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0799 0.1431
Brugia malayi N-terminal motif family protein 0.0218 0.2348 0.5862
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0128 0.0044
Echinococcus granulosus ewsr:fli fusion protein type 0.0013 0.0053 0.0032
Schistosoma mansoni dishevelled 0.0011 0.0031 0.0018
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0031 0.001
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0031 0.001
Schistosoma mansoni microtubule-associated protein tau 0.0678 0.7493 0.749
Mycobacterium ulcerans beta-lactamase 0.0079 0.0799 0.1883
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0031 0.0026
Loa Loa (eye worm) hypothetical protein 0.0013 0.0053 0.0081
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0584 0.1419
Onchocerca volvulus 0.0063 0.0619 0.1486
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1459 0.1448
Schistosoma mansoni elf1 0.0013 0.0053 0.004
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0799 0.1431
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0013 0.0053 0.0032
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0306 0.0286
Giardia lamblia Kinase, PLK 0.0106 0.1101 1
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0799 0.1431
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0306 0.0286
Loa Loa (eye worm) hypothetical protein 0.0018 0.0112 0.0229
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0017 0.0106 0.0094
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0087 0.0066
Loa Loa (eye worm) hypothetical protein 0.0018 0.0112 0.0229
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1459 0.1441
Schistosoma mansoni hypothetical protein 0.0019 0.0124 0.0111
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0053 0.0032
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0124 0.026
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0128 0.0777
Entamoeba histolytica hypothetical protein 0.0035 0.0306 0.201
Schistosoma mansoni hypothetical protein 0.0019 0.0124 0.0111
Brugia malayi hypothetical protein 0.0035 0.0306 0.0719
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0799 0.1961
Brugia malayi Fli-1 protein 0.0265 0.2879 0.7199
Echinococcus multilocularis ETS transcription factor Elf 1 0.0013 0.0053 0.0032
Entamoeba histolytica hypothetical protein 0.0035 0.0306 0.201
Schistosoma mansoni Smad4 0.001 0.0021 0.0008
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.013 0.011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0101 0.018
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0031 0.0026
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0128 0.0215
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0244 0.2639 0.2623
Echinococcus granulosus ETS domain containing protein Elk 1 0.0013 0.0053 0.0032
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0799 0.1431
Schistosoma mansoni smad1 5 8 and 0.001 0.0021 0.0008
Onchocerca volvulus 0.0054 0.0519 0.1232
Loa Loa (eye worm) beta-lactamase 0.0079 0.0799 0.1961
Schistosoma mansoni hypothetical protein 0.0035 0.0306 0.0294
Loa Loa (eye worm) DIX domain-containing protein 0.0011 0.0031 0.0026
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0053 0.0032
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0134 0.1414 0.1403
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0331 0.2699
Mycobacterium ulcerans glutaminase 0.033 0.3601 0.9557
Mycobacterium leprae Probable lipase LipE 0.0079 0.0799 0.1729
Schistosoma mansoni ets 0.0013 0.0053 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0179 0.0186
Brugia malayi polk-prov protein 0.0038 0.0331 0.078
Loa Loa (eye worm) hypothetical protein 0.0041 0.0371 0.0882
Schistosoma mansoni smad 0.001 0.0021 0.0008
Schistosoma mansoni hypothetical protein 0.0054 0.0519 0.0507
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0031 0.001
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0128 0.0107
Entamoeba histolytica serine/threonine protein kinase, putative 0.0106 0.1101 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0244 0.2639 0.2629
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0799 0.1431
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0124 0.026
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0053 0.0032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0026
Onchocerca volvulus Huntingtin homolog 0.0122 0.1276 0.3145
Onchocerca volvulus 0.0024 0.0179 0.0375
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0101 0.018
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0465 0.0969
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0179 0.0186
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0026
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0799 0.2061
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0345 0.3763 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.0195 0.035
Brugia malayi hypothetical protein 0.0267 0.289 0.7228
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0017 0.0106 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0331 0.2699
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0607 0.1477
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0179 0.0735
Echinococcus multilocularis microtubule associated protein 2 0.0678 0.7493 0.7488
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0061 0.0244
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0797 0.882 0.8818
Schistosoma mansoni cpg binding protein 0.0067 0.066 0.0648
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0128 0.0229
Schistosoma mansoni hypothetical protein 0.0013 0.0053 0.004
Loa Loa (eye worm) glutaminase 0.033 0.3601 0.9019
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0799 0.1431
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0465 0.3609
Toxoplasma gondii ABC1 family protein 0.0079 0.0799 0.6285
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0087 0.0074
Echinococcus multilocularis survival motor neuron protein 1 0.0267 0.289 0.2875
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0112 0.02
Loa Loa (eye worm) hypothetical protein 0.0079 0.0799 0.1961
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1459 0.1441
Schistosoma mansoni hypothetical protein 0.0205 0.2198 0.2188
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1101 0.2917
Echinococcus granulosus dna polymerase kappa 0.005 0.0465 0.0445
Echinococcus multilocularis dna polymerase kappa 0.005 0.0465 0.0445
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.1459 0.3623
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0013 0.0053 0.004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0128 0.0215
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0799 0.0787
Brugia malayi DNA-binding protein D-ETS-3 0.0013 0.0053 0.0081
Brugia malayi Ets-domain containing protein 0.0013 0.0053 0.0081
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0799 0.2061
Loa Loa (eye worm) hypothetical protein 0.006 0.0584 0.1419
Leishmania major hypothetical protein, conserved 0.0079 0.0799 0.6964
Echinococcus granulosus GPCR family 2 0.0019 0.0124 0.0103
Loa Loa (eye worm) hypothetical protein 0.0079 0.0799 0.1961
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0017 0.0106 0.0216
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0799 0.7139
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.05 0.1214
Echinococcus multilocularis ets variant gene 4 0.0013 0.0053 0.0032
Echinococcus granulosus geminin 0.0205 0.2198 0.2182
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0026
Echinococcus multilocularis GPCR, family 2 0.0019 0.0124 0.0103
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0465 0.3609
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0584 0.1419
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0124 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1459 0.1448
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0465 0.3976
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0101 0.018
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0179 0.0735
Brugia malayi Ets-domain containing protein 0.0087 0.0888 0.2186
Trichomonas vaginalis glutaminase, putative 0.033 0.3601 1
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0345 0.3763 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0799 0.1961
Trichomonas vaginalis DNA polymerase eta, putative 0.005 0.0465 0.1116
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0128 0.0215
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0087 0.0066
Mycobacterium ulcerans lipase LipD 0.0079 0.0799 0.1883
Schistosoma mansoni hypothetical protein 0.0013 0.0053 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0465 0.3976
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0179 0.0735
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0135 0.0844
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.1101 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0106 0.0216
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0179 0.0735
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1101 0.2917
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0112 0.5
Echinococcus multilocularis cpg binding protein 0.0067 0.066 0.064
Mycobacterium tuberculosis Conserved protein 0.0079 0.0799 0.1431
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0584 0.1419
Schistosoma mansoni ap endonuclease 0.0019 0.0128 0.0115
Brugia malayi ImpB/MucB/SamB family protein 0.0017 0.0106 0.0216
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0799 0.1883
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.04
Brugia malayi beta-lactamase family protein 0.0079 0.0799 0.1961
Brugia malayi serine/threonine-protein kinase plk-2 0.0106 0.1101 0.2721
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0607 0.0595
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0345 0.3763 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0128 0.5
Brugia malayi hypothetical protein 0.0365 0.399 1
Schistosoma mansoni hypothetical protein 0.0205 0.2198 0.2188
Schistosoma mansoni terminal deoxycytidyl transferase 0.0017 0.0106 0.0094
Loa Loa (eye worm) hypothetical protein 0.0218 0.2348 0.5862
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0799 0.078
Leishmania major DNA polymerase kappa, putative 0.0025 0.0195 0.0895
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1459 0.1448
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1101 0.2917
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0799 0.6964
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.005 0.0465 0.1116
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0031 0.0018
Loa Loa (eye worm) histone methyltransferase 0.002 0.013 0.0276
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0124 0.026
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.0888 0.2186
Loa Loa (eye worm) glutaminase 2 0.033 0.3601 0.9019
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0106 0.1101 0.2721
Brugia malayi RNA binding protein 0.0062 0.0607 0.1477
Schistosoma mansoni hypothetical protein 0.0019 0.0124 0.0111
Brugia malayi transcription factor E74 isoform 0.0013 0.0053 0.0081
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0799 0.2061
Echinococcus multilocularis dna polymerase eta 0.0017 0.0106 0.0086
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0179 0.0735
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0465 0.3976
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0508 0.5585 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0179 0.04
Loa Loa (eye worm) RNA binding protein 0.0062 0.0607 0.1477
Echinococcus granulosus cpg binding protein 0.0067 0.066 0.064
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0106 0.1101 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0013 0.0053 0.0081
Loa Loa (eye worm) hypothetical protein 0.0013 0.0053 0.0081
Schistosoma mansoni kinase 0.0054 0.0516 0.0504
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.0106 0.019
Mycobacterium ulcerans hypothetical protein 0.0079 0.0799 0.1883
Onchocerca volvulus 0.0365 0.399 1
Schistosoma mansoni cpg binding protein 0.0067 0.066 0.0648
Echinococcus multilocularis ewsr:fli fusion protein type 0.0013 0.0053 0.0032
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0013 0.0053 0.0081
Schistosoma mansoni hypothetical protein 0.0041 0.0371 0.0359
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0128 0.0159
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0465 0.3976
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0179 0.0186
Loa Loa (eye worm) hypothetical protein 0.0365 0.399 1
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0465 0.3976
Toxoplasma gondii histone lysine methyltransferase SET1 0.012 0.1253 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0135 0.0844
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0031 0.0026
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0376 0.3132
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0179 0.0735
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.0195 0.0895
Brugia malayi glutaminase DH11.1 0.033 0.3601 0.9019
Echinococcus multilocularis ETS transcription factor Elf 5 0.0013 0.0053 0.0032
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1101 0.2917
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0128 0.0215
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.013 0.011
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0607 0.0595
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1459 0.1441
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0465 0.3976
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0106 0.1101 0.1083
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0124 0.0103
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.0888 0.087
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0031 0.0026
Loa Loa (eye worm) ets-domain-containing protein 0.0013 0.0053 0.0081
Brugia malayi beta-lactamase 0.0079 0.0799 0.1961
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0179 0.0321
Schistosoma mansoni ets-related 0.0265 0.2879 0.287
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0607 0.1477
Echinococcus granulosus ETS transcription factor Elf 5 0.0013 0.0053 0.0032
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1101 0.2917
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0799 0.1431
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0031 0.001
Trypanosoma brucei DNA polymerase eta, putative 0.0017 0.0106 0.0575
Echinococcus granulosus microtubule associated protein 2 0.0678 0.7493 0.7488
Loa Loa (eye worm) hypothetical protein 0.0122 0.1276 0.3163
Echinococcus granulosus ETS transcription factor Elf 1 0.0013 0.0053 0.0032
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0106 0.1101 0.1083
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0124 0.0103
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0087 0.0066
Echinococcus granulosus Pleckstrin G protein interacting region 0.0011 0.0031 0.001
Echinococcus multilocularis protein C ets 2 0.0013 0.0053 0.0032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0112 0.0229
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0244 0.2639 0.2623
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0465 0.3976
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0128 0.0159
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0031 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0179 0.0321
Schistosoma mansoni smad1 5 8 and 0.001 0.0021 0.0008
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0179 0.0186
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0799 0.1729
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0799 0.2061
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0017 0.0106 0.0086
Schistosoma mansoni gabp alpha 0.0087 0.0888 0.0877
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0135 0.0844
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0011 0.0031 0.001
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0128 0.0044
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0799 0.078
Onchocerca volvulus Serine\/threonine kinase homolog 0.0106 0.1101 0.2703
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0799 0.0787
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.1459 0.3623
Schistosoma mansoni serine/threonine protein kinase 0.0106 0.1101 0.109
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0799 0.1883
Loa Loa (eye worm) hypothetical protein 0.0018 0.0112 0.0229
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1101 0.2917
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0179 0.04
Loa Loa (eye worm) hypothetical protein 0.0079 0.0799 0.1961
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0306 0.0294
Loa Loa (eye worm) hypothetical protein 0.0122 0.1276 0.3163
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0371 0.0882
Echinococcus multilocularis geminin 0.0205 0.2198 0.2182
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0128 0.027
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1522 0.3783
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0127 0.0268
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0179 0.0186
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.04
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0465 0.3976
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0519 0.1254
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0799 0.6964
Brugia malayi hypothetical protein 0.0011 0.0031 0.0026
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0031 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.0106 0.1101 0.2917
Mycobacterium tuberculosis Conserved protein 0.0079 0.0799 0.1431
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.2348 0.5852
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0345 0.3763 1
Onchocerca volvulus Huntingtin homolog 0.0122 0.1276 0.3145
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0101 0.018
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0799 0.2061
Loa Loa (eye worm) hypothetical protein 0.0075 0.0747 0.1829
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0465 0.3609
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0179 0.0186
Trichomonas vaginalis esterase, putative 0.0079 0.0799 0.2061
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1522 0.3783
Schistosoma mansoni hypothetical protein 0.0019 0.0124 0.0111
Entamoeba histolytica hypothetical protein 0.0035 0.0306 0.201
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0465 0.3976
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0465 0.3609
Schistosoma mansoni ap endonuclease 0.0019 0.0128 0.0115
Echinococcus granulosus dna polymerase eta 0.0017 0.0106 0.0086
Schistosoma mansoni dishevelled 0.0011 0.0031 0.0018
Echinococcus multilocularis dnaJ subfamily B 0.0903 1 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0106 0.1101 1
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0799 0.1883
Schistosoma mansoni hypothetical protein 0.0903 1 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0179 0.0186
Loa Loa (eye worm) hypothetical protein 0.0019 0.0124 0.026
Schistosoma mansoni cpg binding protein 0.0063 0.0619 0.0608
Brugia malayi DIX domain containing protein 0.0011 0.0031 0.0026
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0607 0.1477
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.05 0.1214
Loa Loa (eye worm) hypothetical protein 0.0018 0.0112 0.0229
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0124 0.0103
Schistosoma mansoni DNA polymerase eta 0.0017 0.0106 0.0094
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0607 0.0595
Mycobacterium tuberculosis Conserved protein 0.0079 0.0799 0.1431
Loa Loa (eye worm) hypothetical protein 0.0079 0.0799 0.1961
Schistosoma mansoni glutaminase 0.033 0.3601 0.3593
Loa Loa (eye worm) hypothetical protein 0.0038 0.0331 0.078
Brugia malayi TAR-binding protein 0.0062 0.0607 0.1477
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0607 0.0595
Loa Loa (eye worm) hypothetical protein 0.0024 0.0179 0.04
Brugia malayi hypothetical protein 0.0122 0.1276 0.3163
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.0888 0.087
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0031 0.0018
Giardia lamblia DINP protein human, muc B family 0.0025 0.0195 0.0695
Loa Loa (eye worm) D-ets-2 protein 0.0013 0.0053 0.0081
Loa Loa (eye worm) fli-1 protein 0.0265 0.2879 0.7199

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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