Detailed information for compound 574116

Basic information

Technical information
  • TDR Targets ID: 574116
  • Name: 1-[4-(4-fluorophenyl)piperazin-1-yl]-2-methyl -pentan-1-one
  • MW: 278.365 | Formula: C16H23FN2O
  • H donors: 0 H acceptors: 1 LogP: 3.36 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(C(=O)N1CCN(CC1)c1ccc(cc1)F)C
  • InChi: 1S/C16H23FN2O/c1-3-4-13(2)16(20)19-11-9-18(10-12-19)15-7-5-14(17)6-8-15/h5-8,13H,3-4,9-12H2,1-2H3
  • InChiKey: IYPVKQFMVHZOOK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-(4-fluorophenyl)-1-piperazinyl]-2-methyl-1-pentanone
  • 1-[4-(4-fluorophenyl)piperazino]-2-methyl-pentan-1-one
  • 1-[4-(4-fluorophenyl)piperazin-1-yl]-2-methylpentan-1-one
  • 1-[4-(4-fluorophenyl)-1-piperazinyl]-2-methylpentan-1-one
  • 6199-20-8
  • Oprea1_648810

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis multidrug and toxin extrusion protein 2 0.0021 0.0515 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0592 0.0853
Schistosoma mansoni hypothetical protein 0.0175 0.6766 1
Echinococcus granulosus beta-adrenergic receptor kinase 0.0013 0.0197 0.0125
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0011 0.012 0.0516
Schistosoma mansoni lamin 0.0014 0.0251 0.0264
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1459 0.2071
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1459 0.1396
Schistosoma mansoni calcium-activated potassium channel 0.0175 0.6766 1
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0159 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.0423 0.0417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0592 0.0853
Mycobacterium tuberculosis Probable reductase 0.0074 0.2653 0.3757
Echinococcus multilocularis regulator of G protein signaling 3 0.0013 0.0197 0.0125
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0423 0.0609
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0515 0.4894
Toxoplasma gondii target of rapamycin (TOR), putative 0.0023 0.0592 0.0755
Leishmania major DNA polymerase kappa, putative 0.0019 0.0423 0.3873
Schistosoma mansoni dihydropteridine reductase 0.0012 0.0159 0.0128
Mycobacterium tuberculosis Probable oxidoreductase 0.0012 0.0159 0.0124
Plasmodium vivax glutathione reductase, putative 0.0032 0.0976 0.1314
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0012 0.0159 0.0124
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0011 0.012 0.0068
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0012 0.0159 0.0086
Echinococcus granulosus regulator of G protein signaling 3 0.0013 0.0197 0.0125
Loa Loa (eye worm) glutathione reductase 0.0032 0.0976 0.1077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0159 0.0102
Plasmodium falciparum thioredoxin reductase 0.0032 0.0976 0.1314
Loa Loa (eye worm) hypothetical protein 0.0014 0.0251 0.0211
Echinococcus granulosus intermediate filament protein 0.0014 0.0251 0.0178
Entamoeba histolytica hypothetical protein 0.0053 0.1808 0.2436
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0011 0.012 0.0068
Loa Loa (eye worm) hypothetical protein 0.0217 0.8449 1
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.018 0.6939 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0011 0.012 0.0516
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0012 0.0159 0.0102
Loa Loa (eye worm) hypothetical protein 0.0029 0.0855 0.0933
Brugia malayi regulator of G-protein signaling egl-10 0.0013 0.0197 0.0358
Leishmania major phosphatidylinositol 3-related kinase, putative 0.001 0.0084 0.0112
Mycobacterium tuberculosis Possible oxidoreductase 0.0012 0.0159 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0403 0.058
Trypanosoma brucei pteridine reductase 1 0.0012 0.0159 0.0947
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0339 0.0487
Giardia lamblia NADH oxidase lateral transfer candidate 0.0011 0.012 0.0065
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0197 0.0284
Loa Loa (eye worm) hypothetical protein 0.0175 0.6766 0.799
Brugia malayi PXA domain containing protein 0.0013 0.0197 0.0358
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0031 0.0911 0.1176
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0423 0.0522
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0031 0.0911 0.928
Schistosoma mansoni multidrug resistance protein 0.0021 0.0515 0.066
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0515 0.4894
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0197 0.0284
Brugia malayi glutathione reductase 0.0032 0.0976 0.1767
Schistosoma mansoni hypothetical protein 0.0091 0.3335 0.4872
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.018 0.6939 1
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0012 0.0159 0.0086
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0074 0.2653 0.3757
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0012 0.0159 0.0124
Plasmodium falciparum thioredoxin reductase 0.0011 0.012 0.0068
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0011 0.012 0.0516
Schistosoma mansoni lamin 0.0014 0.0251 0.0264
Trichomonas vaginalis mercuric reductase, putative 0.0011 0.012 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0656 0.0945
Echinococcus granulosus thioredoxin glutathione reductase 0.0032 0.0976 0.0909
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0011 0.012 0.0068
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0012 0.0159 0.0124
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.001 0.0084 0.0112
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0024 0.0657 0.6469
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0011 0.012 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0197 0.0284
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0014 0.0251 0.0211
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0159 0.0124
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.001 0.0084 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0197 0.0284
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0159 0.0124
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0031 0.0911 0.0843
Entamoeba histolytica hypothetical protein 0.0013 0.0197 0.0174
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0053 0.1808 0.2436
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0082 0.2986 0.4242
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0159 0.0124
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0011 0.012 0.0068
Brugia malayi regulator of G-protein signaling rgs-7 0.0013 0.0197 0.0358
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.012 0.0516
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0159 0.0124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.012 0.0516
Loa Loa (eye worm) oxidoreductase 0.0012 0.0159 0.0102
Schistosoma mansoni hypothetical protein 0.0091 0.3335 0.4872
Leishmania major pteridine reductase 1 0.0012 0.0159 0.0947
Loa Loa (eye worm) hypothetical protein 0.0013 0.0197 0.0148
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0186 0.7192 1
Brugia malayi PXA domain containing protein 0.0013 0.0197 0.0358
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0159 0.0124
Toxoplasma gondii thioredoxin reductase 0.0032 0.0976 0.1314
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0011 0.012 0.0516
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0011 0.012 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0197 0.0284
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0423 0.3873
Onchocerca volvulus 0.0014 0.0251 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0592 0.0853
Mycobacterium ulcerans oxidoreductase 0.0012 0.0159 0.0124
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0013 0.0197 0.0358
Echinococcus multilocularis lamin dm0 0.0014 0.0251 0.0178
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0013 0.0197 0.0185
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0012 0.0159 0.0124
Echinococcus granulosus regulator of G protein signaling 7 0.0013 0.0197 0.0125
Brugia malayi hypothetical protein 0.0013 0.0197 0.0358
Mycobacterium tuberculosis Probable dehydrogenase 0.0074 0.2653 0.3757
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.018 0.6939 1
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0012 0.0159 0.0124
Echinococcus multilocularis beta adrenergic receptor kinase 0.0013 0.0197 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0911 0.1312
Onchocerca volvulus Huntingtin homolog 0.0119 0.4468 1
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0012 0.0159 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0423 0.3873
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0159 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0911 0.1312
Leishmania major hypothetical protein, conserved 0.0021 0.0515 0.4894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0339 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0084 0.012
Echinococcus granulosus lamin 0.0014 0.0251 0.0178
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.001 0.0084 0.001
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0423 0.0509
Loa Loa (eye worm) hypothetical protein 0.0066 0.2326 0.2689
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.001 0.0084 0.0152
Trypanosoma brucei unspecified product 0.0013 0.0188 0.127
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0423 0.3873
Echinococcus multilocularis expressed protein 0.0255 1 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0013 0.0197 0.0148
Loa Loa (eye worm) hypothetical protein 0.0073 0.263 0.3052
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0011 0.012 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0084 0.012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0592 0.0853
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0423 0.0609
Brugia malayi Muscleblind-like protein 0.0145 0.5521 1
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0013 0.0197 0.0125
Trypanosoma brucei MATE efflux family protein, putative 0.0021 0.0515 0.4894
Trypanosoma brucei oxidoreductase-like protein 0.0012 0.0159 0.0947
Schistosoma mansoni regulator of G protein signaling 0.0013 0.0197 0.0185
Echinococcus multilocularis lamin 0.0014 0.0251 0.0178
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0159 0.0124
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0105 0.0038
Brugia malayi Regulator of G protein signaling domain containing protein 0.0013 0.0197 0.0358
Echinococcus multilocularis dna polymerase eta 0.0019 0.0423 0.0352
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0423 0.0352
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0011 0.012 0.0516
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0197 0.0185
Entamoeba histolytica hypothetical protein 0.0013 0.0197 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0729 0.105
Echinococcus multilocularis small conductance calcium activated potassium 0.0175 0.6766 0.6742
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.018 0.6939 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0031 0.0911 0.928
Brugia malayi intermediate filament protein 0.0014 0.0251 0.0454
Brugia malayi Cytochrome P450 family protein 0.0018 0.0391 0.0708
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0656 0.0945
Trypanosoma brucei cytochrome P450, putative 0.0011 0.0105 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0423 0.3873
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0011 0.0105 0.0046
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0911 0.0999
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0197 0.0284
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0074 0.2653 0.3757
Schistosoma mansoni z-protein (S1r protein) 0.0013 0.0197 0.0185
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.0159 0.0124
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0159 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0338 0.0486
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0159 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0338 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0501 0.0722
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0015 0.0255 0.201
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.001 0.0084 0.0015
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0012 0.0159 0.012
Echinococcus multilocularis muscleblind protein 1 0.0145 0.5521 0.5488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0592 0.0853
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0082 0.2986 0.4242
Schistosoma mansoni DNA polymerase eta 0.0019 0.0423 0.0522
Leishmania major cytochrome p450-like protein 0.0011 0.0105 0.0348
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.012 0.0516
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.012 0.0516
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0011 0.012 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.041 0.059
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0423 0.3873
Schistosoma mansoni axis inhibition protein axin 0.0013 0.0197 0.0185
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.001 0.0084 0.0112
Echinococcus multilocularis regulator of G protein signaling 0.0013 0.0197 0.0125
Trypanosoma brucei membrane transporter protein, putative 0.0021 0.0515 0.4894
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0391 0.0379
Loa Loa (eye worm) hypothetical protein 0.0013 0.0197 0.0148
Loa Loa (eye worm) thioredoxin reductase 0.0032 0.0976 0.1077
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0074 0.2653 0.3757
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0423 0.0491
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0032 0.0976 0.1314
Plasmodium vivax thioredoxin reductase, putative 0.0032 0.0976 0.1314
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0423 0.3873
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0011 0.012 0.0047
Echinococcus multilocularis muscleblind protein 0.0145 0.5521 0.5488
Echinococcus multilocularis axis inhibition protein axin 0.0013 0.0197 0.0125
Schistosoma mansoni intermediate filament proteins 0.0014 0.0251 0.0264
Loa Loa (eye worm) PXA domain-containing protein 0.0013 0.0197 0.0148
Loa Loa (eye worm) hypothetical protein 0.0013 0.0197 0.0148
Schistosoma mansoni regulator of G protein signaling 0.0013 0.0197 0.0185
Schistosoma mansoni regulator of G protein signaling 0.0013 0.0197 0.0185
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0012 0.0159 0.0947
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0012 0.0159 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0656 0.0945
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0423 0.3873
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0339 0.0487
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0423 0.3873
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0012 0.0159 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0338 0.0486
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0012 0.0159 0.0124
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0197 0.0185
Brugia malayi Cytochrome P450 family protein 0.0011 0.0105 0.0191
Echinococcus multilocularis regulator of G protein signaling 7 0.0013 0.0197 0.0125
Trypanosoma cruzi membrane transporter protein, putative 0.0021 0.0515 0.4894
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0012 0.0159 0.0124
Echinococcus multilocularis regulator of G protein signaling 7 0.0013 0.0197 0.0125
Trypanosoma brucei unspecified product 0.0019 0.0423 0.3873
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0159 0.0124
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0011 0.012 0.0068
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0013 0.0197 0.0185
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0031 0.0911 0.1176
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0423 0.3873
Leishmania major phosphatidylinositol 3-kinase, putative 0.001 0.0084 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0592 0.0853
Leishmania major oxidoreductase-like protein 0.0012 0.0159 0.0947
Echinococcus multilocularis musashi 0.0014 0.0251 0.0178
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0423 0.0766
Schistosoma mansoni axis inhibition protein axin 0.0013 0.0197 0.0185
Entamoeba histolytica hypothetical protein 0.0013 0.0197 0.0174
Loa Loa (eye worm) intermediate filament protein 0.0014 0.0251 0.0211
Loa Loa (eye worm) RGS-3 protein 0.0013 0.0197 0.0148
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.018 0.6939 1
Brugia malayi hypothetical protein 0.0083 0.3037 0.55
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1459 0.1396
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0012 0.0159 0.0128
Brugia malayi hypothetical protein 0.0013 0.0197 0.0358
Echinococcus granulosus multidrug and toxin extrusion protein 2 0.0021 0.0515 0.0445
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0084 0.012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.012 0.0516
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0031 0.0911 0.1251
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0031 0.0911 0.928
Mycobacterium tuberculosis Probable oxidoreductase 0.0082 0.2986 0.4242
Plasmodium falciparum glutathione reductase 0.0032 0.0976 0.1314
Trypanosoma cruzi target of rapamycin kinase 3 0.0024 0.0657 0.6469
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0159 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0515 0.4894
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0013 0.0197 0.0148
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0031 0.0911 0.928
Loa Loa (eye worm) hypothetical protein 0.0145 0.5521 0.6504
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0423 0.0522
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0159 0.0124
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0031 0.0911 0.928
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0074 0.2653 0.3757
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0031 0.0911 0.928
Brugia malayi Regulator of G protein signaling domain containing protein 0.0013 0.0197 0.0358
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.0159 0.0124
Mycobacterium tuberculosis Possible oxidoreductase 0.0012 0.0159 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0515 0.4894
Toxoplasma gondii NADPH-glutathione reductase 0.0011 0.012 0.0068
Loa Loa (eye worm) hypothetical protein 0.0014 0.024 0.0198
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0012 0.0159 0.0947
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.001 0.0084 0.0112
Trichomonas vaginalis glutathione reductase, putative 0.0011 0.012 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0515 0.4894
Echinococcus granulosus axis inhibition protein axin 0.0013 0.0197 0.0125
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0159 0.0288
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0159 0.0124
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1459 0.1396
Schistosoma mansoni serine/threonine protein kinase 0.0013 0.0197 0.0185
Giardia lamblia DINP protein human, muc B family 0.0019 0.0423 0.0491
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0031 0.0911 0.0843
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.041 0.059
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0012 0.0159 0.0124
Plasmodium falciparum glutathione reductase 0.0011 0.012 0.0068
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0011 0.012 0.0516
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0011 0.012 0.0068
Trypanosoma cruzi trypanothione reductase, putative 0.0011 0.012 0.0516
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0423 0.3873
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0656 0.0945
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0976 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1459 0.2071
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0423 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0474 0.0683
Trichomonas vaginalis ap endonuclease, putative 0.001 0.0074 0.0106
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0012 0.0159 0.0947
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0423 0.3873
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0159 0.0124
Echinococcus granulosus lamin dm0 0.0014 0.0251 0.0178
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0024 0.0657 0.6469
Treponema pallidum NADH oxidase 0.0011 0.012 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0084 0.012
Loa Loa (eye worm) hypothetical protein 0.0119 0.4468 0.5247
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0423 0.3873
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0105 0.0348
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0159 0.0124
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0423 0.0509
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0423 0.3873
Brugia malayi exodeoxyribonuclease III family protein 0.001 0.0074 0.0134
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0013 0.0197 0.0185
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0423 0.3873
Leishmania major DNA polymerase eta, putative 0.0019 0.0423 0.3873
Loa Loa (eye worm) cytochrome P450 family protein 0.0011 0.0105 0.0038
Echinococcus granulosus geminin 0.0091 0.3335 0.3285
Loa Loa (eye worm) retinol dehydrogenase 12 0.0012 0.0159 0.0102
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0911 0.165
Plasmodium vivax enoyl-acyl carrier protein reductase 0.018 0.6939 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.001 0.0084 0.001
Brugia malayi A-kinase anchor protein 10, precursor 0.0013 0.0197 0.0358
Leishmania major hypothetical protein, conserved 0.0021 0.0515 0.4894
Echinococcus multilocularis regulator of G protein signaling 3 0.0013 0.0197 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0403 0.058
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0012 0.0159 0.0124
Onchocerca volvulus 0.0014 0.0251 0.0212
Loa Loa (eye worm) hypothetical protein 0.0013 0.0197 0.0148
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0159 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0188 0.127
Echinococcus granulosus dna polymerase eta 0.0019 0.0423 0.0352
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0159 0.0124
Trichomonas vaginalis hypothetical protein 0.018 0.6939 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.0159 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0656 0.0945
Echinococcus granulosus muscleblind protein 0.0145 0.5521 0.5488
Echinococcus multilocularis Regulator of G protein signaling 20 0.0013 0.0197 0.0125
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0011 0.012 0.0516
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1459 0.2071
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0011 0.012 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0188 0.127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.041 0.059
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0423 0.0509
Schistosoma mansoni calcium-activated potassium channel 0.0139 0.5289 0.7794
Echinococcus multilocularis thioredoxin glutathione reductase 0.0032 0.0976 0.0909
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0159 0.0124
Loa Loa (eye worm) hypothetical protein 0.0145 0.5521 0.6504
Trypanosoma brucei membrane transporter protein, putative 0.0021 0.0515 0.4894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0592 0.0853
Loa Loa (eye worm) hypothetical protein 0.0013 0.0197 0.0148
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0012 0.0159 0.0947
Trypanosoma cruzi cytochrome P450, putative 0.0011 0.0105 0.0348
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0159 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0423 0.3873
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0339 0.0487
Brugia malayi Cytochrome P450 family protein 0.0011 0.0105 0.0191
Echinococcus granulosus axis inhibition protein axin 0.0013 0.0197 0.0125
Chlamydia trachomatis oxoacy-ACP reductase 0.0012 0.0159 0.0057
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0159 0.0124
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0011 0.012 0.0516
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0082 0.2986 0.4169
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0159 0.0124
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0423 0.3873
Plasmodium falciparum enoyl-acyl carrier reductase 0.018 0.6939 1
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0012 0.0159 0.0947
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0011 0.012 0.0047
Echinococcus multilocularis Multi antimicrobial extrusion protein MatE 0.0019 0.0441 0.037
Trichomonas vaginalis ap endonuclease, putative 0.001 0.0074 0.0106
Trypanosoma brucei unspecified product 0.0013 0.0188 0.127
Giardia lamblia DNA repair protein RAD52 0.0186 0.7192 1
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.018 0.6939 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0013 0.0197 0.0284
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0011 0.012 0.0516
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0011 0.012 0.0516
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0159 0.0124
Echinococcus multilocularis geminin 0.0091 0.3335 0.3285
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0423 0.0766
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0012 0.0159 0.0124
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1459 0.1396
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0012 0.0159 0.0947
Trypanosoma brucei membrane transporter protein, putative 0.0021 0.0515 0.4894
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0011 0.012 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0423 0.3873
Echinococcus granulosus Regulator of G protein signaling 20 0.0013 0.0197 0.0125
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.1459 0.2643
Loa Loa (eye worm) CYP4Cod1 0.0011 0.0105 0.0038
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.1459 0.1654
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0074 0.2653 0.3678
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0159 0.0124
Echinococcus granulosus regulator of G protein signaling 3 0.0013 0.0197 0.0125
Echinococcus granulosus dna polymerase kappa 0.0019 0.0423 0.0352
Loa Loa (eye worm) hypothetical protein 0.0119 0.4468 0.5247
Loa Loa (eye worm) phosphatidylinositol 3 0.001 0.0084 0.0012
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0423 0.0352
Echinococcus multilocularis axis inhibition protein axin 0.0013 0.0197 0.0125
Loa Loa (eye worm) hypothetical protein 0.0013 0.0197 0.0148
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0013 0.0184 0.1216
Brugia malayi Intermediate filament tail domain containing protein 0.0014 0.0251 0.0454
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0011 0.012 0.0218
Leishmania major trypanothione reductase 0.0032 0.0976 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0012 0.0159 0.0947
Echinococcus granulosus regulator of G protein signaling 7 0.0013 0.0197 0.0125
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0013 0.0197 0.0148
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0011 0.012 0.0516
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0423 0.3873
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0423 0.0417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0911 0.1312
Giardia lamblia GTOR 0.0031 0.0911 0.1176
Echinococcus granulosus small conductance calcium activated potassium 0.0175 0.6766 0.6742
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0423 0.3873
Schistosoma mansoni regulator of G protein signaling 0.0013 0.0197 0.0185
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0188 0.127
Brugia malayi hypothetical protein 0.0119 0.4468 0.8093
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0159 0.0124
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0159 0.0124
Trypanosoma brucei trypanothione reductase 0.0032 0.0976 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0013 0.0197 0.0125
Schistosoma mansoni regulator of G protein signaling 0.0013 0.0197 0.0185
Onchocerca volvulus Huntingtin homolog 0.0119 0.4468 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0423 0.3873
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0423 0.0509
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0084 0.012
Brugia malayi Thioredoxin reductase 0.0032 0.0976 0.1767

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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