Detailed information for compound 57480

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 624.932 | Formula: C37H68O7
  • H donors: 3 H acceptors: 4 LogP: 9.63 Rotable bonds: 25
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCC[C@@H](CCC[C@@H]([C@H]1CC[C@@H](O1)[C@H]1CC[C@@H](O1)[C@@H](CCCCCCCCCCCCC1C[C@@H](OC1=O)C)O)O)O
  • InChi: 1S/C37H68O7/c1-3-4-5-15-19-30(38)20-17-22-32(40)34-24-26-36(44-34)35-25-23-33(43-35)31(39)21-16-13-11-9-7-6-8-10-12-14-18-29-27-28(2)42-37(29)41/h28-36,38-40H,3-27H2,1-2H3/t28-,29?,30-,31+,32-,33+,34+,35+,36+/m0/s1
  • InChiKey: SKLZKDSSSZNRDJ-BWDLWKDKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) TYRA-2 protein 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0037
Loa Loa (eye worm) histone deacetylase 7A 0.0043 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0035 0.1399
Echinococcus granulosus tyrosine protein kinase Src42A 0.0383 0.0691 0.0691
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0049 0.0035 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Schistosoma mansoni tyrosine kinase 0.0066 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0039 0.0015 0.0015
Trypanosoma cruzi nicotinate phosphoribosyltransferase, putative 0.0078 0.0091 0.6986
Loa Loa (eye worm) melatonin receptor type 1A 0.0051 0.0038 0.0038
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0051 0.0038 0.0038
Brugia malayi hypothetical protein 0.0066 0.0068 0.0068
Brugia malayi hypothetical protein 0.0051 0.0038 0.0038
Brugia malayi Variant SH3 domain containing protein 0.0049 0.0035 0.0035
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0098 0.0131 0.751
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0037
Brugia malayi SH2 domain containing protein 0.005 0.0037 0.0037
Entamoeba histolytica protein kinase, putative 0.0049 0.0035 0.0319
Onchocerca volvulus 0.0066 0.0068 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0099 0.0134 0.0134
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0448 0.0819 0.0819
Echinococcus multilocularis transfer RNA-Ala 0.0049 0.0035 0.0035
Onchocerca volvulus 0.0051 0.0038 0.5549
Brugia malayi protein-tyrosine kinase 0.0049 0.0035 0.0035
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0051 0.0038 0.5549
Mycobacterium tuberculosis Nicotinic acid phosphoribosyltransferase PncB2 0.0078 0.0091 0.5
Loa Loa (eye worm) hypothetical protein 0.0049 0.0035 0.0035
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0041 0.0018 0.0018
Echinococcus granulosus serotonin receptor 0.0051 0.0038 0.0038
Echinococcus granulosus expressed conserved protein 0.005 0.0037 0.0037
Brugia malayi SH2 domain containing protein 0.005 0.0037 0.0037
Schistosoma mansoni adenoreceptor 0.0051 0.0038 0.0038
Echinococcus granulosus SHC transforming protein 3 0.005 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0051 0.0038 0.0038
Entamoeba histolytica protein kinase, putative 0.0052 0.004 0.0402
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0023 0.1727
Echinococcus granulosus neuropeptide Y receptor 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0038 0.0038
Trichomonas vaginalis histone deacetylase, putative 0.0098 0.0131 0.751
Brugia malayi Spectrin alpha chain 0.0049 0.0035 0.0035
Echinococcus multilocularis histone deacetylase 0.0043 0.0023 0.0023
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0448 0.0819 0.0819
Brugia malayi SH2 domain containing protein 0.005 0.0037 0.0037
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0051 0.0038 0.0038
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0051 0.0038 0.0038
Schistosoma mansoni serine/threonine-protein kinase 0.008 0.0095 0.0095
Echinococcus multilocularis nostrin 0.0049 0.0035 0.0035
Onchocerca volvulus 0.0051 0.0038 0.5549
Toxoplasma gondii histone deacetylase HDAC1 0.0043 0.0023 0.1401
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Trichomonas vaginalis AGC family protein kinase 0.0118 0.017 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0035 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0066 0.0066
Onchocerca volvulus 0.0051 0.0038 0.5549
Brugia malayi Guanylate kinase family protein 0.0049 0.0035 0.0035
Schistosoma mansoni dreadlocks/dock 0.0049 0.0035 0.0035
Brugia malayi hypothetical protein 0.0051 0.0038 0.0038
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0051 0.0038 0.0038
Schistosoma mansoni serine/threonine-protein kinase 0.008 0.0095 0.0095
Echinococcus granulosus G protein coupled receptor 139 0.0051 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase Abl 0.0201 0.0333 0.0333
Echinococcus granulosus orexin receptor type 2 0.0051 0.0038 0.0038
Echinococcus multilocularis epidermal growth factor receptor 0.0338 0.0603 0.0603
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0098 0.0131 0.751
Brugia malayi SH2 domain containing protein 0.005 0.0037 0.0037
Brugia malayi histone deacetylase 1 (HD1) 0.0098 0.0131 0.0131
Loa Loa (eye worm) SH2 domain-containing protein 0.005 0.0037 0.0037
Echinococcus granulosus peptide allatostatin:somatostatin 0.0051 0.0038 0.0038
Brugia malayi Protein kinase domain containing protein 0.0118 0.017 0.017
Brugia malayi neuropeptide F receptor 0.0051 0.0038 0.0038
Echinococcus granulosus nicotinamide phosphoribosyltransferase 0.042 0.0764 0.0764
Echinococcus multilocularis serine:threonine protein kinase N2 0.0039 0.0015 0.0015
Brugia malayi protein kinase C II. 0.0039 0.0015 0.0015
Echinococcus multilocularis histone deacetylase 7 0.0043 0.0023 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0038 0.0038
Onchocerca volvulus 0.0051 0.0038 0.5549
Brugia malayi Protein kinase domain containing protein 0.0039 0.0015 0.0015
Leishmania major nicotinate phosphoribosyltransferase, putative 0.0078 0.0091 0.6357
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0037
Echinococcus granulosus alpha 1A adrenergic receptor 0.0051 0.0038 0.0038
Echinococcus multilocularis insulin receptor 0.0118 0.017 0.017
Loa Loa (eye worm) thyroid receptor interactor 0.0049 0.0035 0.0035
Echinococcus granulosus histone deacetylase 0.0043 0.0023 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0038 0.0038
Schistosoma mansoni apoptosis stimulating of P53 0.0049 0.0035 0.0035
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0051 0.0038 0.0038
Brugia malayi follicle stimulating hormone receptor 0.0051 0.0038 0.0038
Echinococcus multilocularis sex peptide receptor 0.0051 0.0038 0.0038
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0051 0.0038 0.0038
Brugia malayi hypothetical protein 0.0051 0.0038 0.0038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0038 0.0038
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0039 0.0015 0.0015
Mycobacterium tuberculosis Nicotinic acid phosphoribosyltransferase PncB1 0.0078 0.0091 0.5
Schistosoma mansoni biogenic amine receptor 0.0051 0.0038 0.0038
Brugia malayi Protein kinase domain containing protein 0.0066 0.0068 0.0068
Echinococcus multilocularis dro:myosuppressin receptor 0.0051 0.0038 0.0038
Brugia malayi hypothetical protein 0.0051 0.0038 0.0038
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0068 0.0068
Echinococcus granulosus g protein coupled receptor 0.0051 0.0038 0.0038
Schistosoma mansoni neuropeptide F-like receptor 0.0051 0.0038 0.0038
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0038 0.0038
Echinococcus granulosus neuropeptides capa receptor 0.0051 0.0038 0.0038
Onchocerca volvulus 0.0049 0.0035 0.5054
Schistosoma mansoni suppressor of cytokine signaling 0.005 0.0037 0.0037
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.005 0.0037 0.5413
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0015 0.0167
Echinococcus multilocularis allatostatin A receptor 0.0051 0.0038 0.0038
Echinococcus granulosus dro:myosuppressin receptor 0.0051 0.0038 0.0038
Loa Loa (eye worm) TK/ABL protein kinase 0.029 0.0509 0.0509
Echinococcus multilocularis G-protein coupled receptor, putative 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0037
Echinococcus granulosus tachykinin peptides receptor 99D 0.0051 0.0038 0.0038
Brugia malayi Protein kinase domain containing protein 0.0118 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0051 0.0038 0.0038
Echinococcus multilocularis fmrfamide receptor 0.0051 0.0038 0.0038
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0051 0.0038 0.0038
Plasmodium vivax histone deacetylase 2, putative 0.0043 0.0023 0.1727
Brugia malayi G protein-coupled receptor 0.0051 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0051 0.0038 0.0038
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0099 0.0134 0.0134
Loa Loa (eye worm) protein-tyrosine phosphatase 0.005 0.0037 0.0037
Echinococcus granulosus tyrosine protein kinase Blk 0.0399 0.0723 0.0723
Echinococcus granulosus histone deacetylase 1 0.0098 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Leishmania major histone deacetylase, putative 0.0098 0.0131 1
Onchocerca volvulus 0.0051 0.0038 0.5549
Echinococcus granulosus fmrfamide receptor 0.0051 0.0038 0.0038
Schistosoma mansoni serine/threonine kinase 0.0039 0.0015 0.0015
Schistosoma mansoni C-fyn 0.0049 0.0035 0.0035
Leishmania major histone deacetylase, putative 0.0098 0.0131 1
Brugia malayi Serotonin receptor 0.0051 0.0038 0.0038
Schistosoma mansoni tyrosine kinase 0.024 0.041 0.041
Echinococcus multilocularis tyrosine protein kinase Blk 0.0399 0.0723 0.0723
Brugia malayi Src substrate cortactin 0.0049 0.0035 0.0035
Trichomonas vaginalis AGC family protein kinase 0.0118 0.017 1
Echinococcus granulosus intersectin 2 0.0049 0.0035 0.0035
Brugia malayi Pre-B cell enhancing factor precursor 0.042 0.0764 0.0764
Echinococcus multilocularis histone deacetylase 6 0.0045 0.0028 0.0028
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0049 0.0035 0.0035
Brugia malayi Variant SH3 domain containing protein 0.0049 0.0035 0.0035
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0076 0.0087 0.5928
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Schistosoma mansoni nicotinate phosphoribosyltransferase 0.0078 0.0091 0.0091
Brugia malayi hypothetical protein 0.0051 0.0038 0.0038
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.005 0.0037 0.0037
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0051 0.0038 0.0038
Leishmania major hypothetical protein, conserved 0.0049 0.0035 0.1109
Echinococcus granulosus histone deacetylase 6 0.0045 0.0028 0.0028
Trypanosoma cruzi histone deacetylase 1, putative 0.0098 0.0131 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0038 0.0038
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0039 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Brugia malayi Protein kinase domain containing protein 0.0066 0.0068 0.0068
Echinococcus multilocularis 0.01 0.0135 0.0135
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0099 0.0134 0.0134
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0023 0.0023
Entamoeba histolytica hypothetical protein 0.0049 0.0035 0.0319
Schistosoma mansoni opsin-like receptor 0.0051 0.0038 0.0038
Echinococcus granulosus neuropeptide s receptor 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Brugia malayi hypothetical protein 0.0051 0.0038 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0015 0.0015
Echinococcus multilocularis neuropeptide Y receptor 0.0051 0.0038 0.0038
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0049 0.0035 0.2645
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0049 0.0035 0.0035
Brugia malayi AKH receptor 0.0051 0.0038 0.0038
Entamoeba histolytica hypothetical protein 0.0049 0.0035 0.0319
Schistosoma mansoni sorbin 0.0049 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0049 0.0035 0.0035
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0038 0.0038
Echinococcus multilocularis neuropeptides capa receptor 0.0051 0.0038 0.0038
Echinococcus multilocularis tyrosine kinase 0.0066 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0051 0.0038 0.0038
Loa Loa (eye worm) STAT protein 0.005 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.005 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Echinococcus multilocularis nervana 2 0.0074 0.0084 0.0084
Echinococcus granulosus suppressor of cytokine signaling 6 0.005 0.0037 0.0037
Giardia lamblia Histone deacetylase 0.0098 0.0131 1
Schistosoma mansoni hypothetical protein 0.0051 0.0038 0.0038
Onchocerca volvulus Neuropeptide F receptor homolog 0.0051 0.0038 0.5549
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0068 0.0068
Brugia malayi Dopamine receptor protein 2 0.0051 0.0038 0.0038
Brugia malayi Histone deacetylase family protein 0.0043 0.0023 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0015 0.0015
Entamoeba histolytica nicotinate phosphoribosyltransferase, putative 0.0078 0.0091 0.1251
Treponema pallidum nicotinate phosphoribosyltransferase 0.0078 0.0091 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.0018 0.0018
Schistosoma mansoni amine GPCR 0.0051 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0399 0.0723 0.0723
Onchocerca volvulus 0.005 0.0037 0.5413
Trichomonas vaginalis histone deacetylase, putative 0.0098 0.0131 0.751
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Brugia malayi G protein-coupled receptor F59B2.13 0.0051 0.0038 0.0038
Echinococcus multilocularis neuropeptide receptor 0.0051 0.0038 0.0038
Schistosoma mansoni Dab2-interacting protein-like 0.0049 0.0035 0.0035
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0039 0.0015 0.0015
Loa Loa (eye worm) TK protein kinase 0.0349 0.0624 0.0624
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0035 0.2645
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0115 0.0165 0.0165
Echinococcus multilocularis SH2 domain containing protein 7 0.005 0.0037 0.0037
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0051 0.0038 0.0038
Echinococcus multilocularis NCK adaptor protein 0.0099 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Loa Loa (eye worm) p53BP2 0.0049 0.0035 0.0035
Echinococcus multilocularis intersectin 2 0.0049 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase shark 0.0066 0.0068 0.0068
Echinococcus multilocularis fmrfamide receptor 0.0051 0.0038 0.0038
Brugia malayi sulfakinin receptor protein 0.0051 0.0038 0.0038
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0049 0.0035 0.0035
Echinococcus multilocularis tensin 0.005 0.0037 0.0037
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0049 0.0035 0.0035
Onchocerca volvulus 0.0066 0.0068 1
Echinococcus multilocularis neuropeptides capa receptor 0.0051 0.0038 0.0038
Onchocerca volvulus 0.0051 0.0038 0.5549
Schistosoma mansoni hypothetical protein 0.005 0.0037 0.0037
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0049 0.0035 0.0035
Loa Loa (eye worm) histone deacetylase 0.0043 0.0023 0.0023
Toxoplasma gondii histone deacetylase HDAC3 0.0098 0.0131 0.8113
Schistosoma mansoni nck2/grb4 0.0099 0.0134 0.0134
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0038 0.0038
Toxoplasma gondii histone deacetylase HDAC2 0.0098 0.0131 0.8113
Brugia malayi Variant SH3 domain containing protein 0.005 0.0037 0.0037
Echinococcus multilocularis protein kinase c iota type 0.0039 0.0015 0.0015
Brugia malayi SH2 domain containing protein 0.0066 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0037
Echinococcus multilocularis expressed protein 0.0049 0.0035 0.0035
Onchocerca volvulus 0.0049 0.0035 0.5054
Loa Loa (eye worm) AGC/PKN protein kinase 0.0039 0.0015 0.0015
Schistosoma mansoni neuropeptide receptor 0.0051 0.0038 0.0038
Plasmodium vivax histone deacetylase 1, putative 0.0098 0.0131 1
Brugia malayi SH2 domain containing protein 0.005 0.0037 0.0037
Loa Loa (eye worm) histone deacetylase 1 0.0098 0.0131 0.0131
Brugia malayi putative neuropeptide receptor NPR1 0.0051 0.0038 0.0038
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0066 0.0068 0.0875
Schistosoma mansoni tyrosine kinase 0.0338 0.0603 0.0603
Echinococcus granulosus Spectrin alpha actinin 0.0049 0.0035 0.0035
Schistosoma mansoni nicotinate phosphoribosyltransferase related pre-B cell enhancing factor 0.0078 0.0091 0.0091
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0055 0.0046 0.0046
Schistosoma mansoni biogenic amine (5HT) receptor 0.0051 0.0038 0.0038
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0051 0.0038 0.0038
Brugia malayi SRC-1 0.0448 0.0819 0.0819
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.005 0.0037 0.0037
Schistosoma mansoni neuropeptide F-like receptor 0.0051 0.0038 0.0038
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0038 0.0038
Brugia malayi SH3 domain containing protein 0.0049 0.0035 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0035 0.2645
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0068 0.0068
Echinococcus granulosus tyrosine protein kinase Srms 0.0066 0.0068 0.0068
Brugia malayi Melatonin receptor type 1A 0.0051 0.0038 0.0038
Loa Loa (eye worm) protein-tyrosine kinase 0.0049 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0049 0.0035 0.0035
Brugia malayi Dopamine receptor protein 1 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0049 0.0035 0.0035
Echinococcus multilocularis nervana 2 0.0074 0.0084 0.0084
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0099 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0037
Brugia malayi Protein kinase domain containing protein 0.0066 0.0068 0.0068
Brugia malayi G-protein coupled receptor 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0037
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0448 0.0819 0.0819
Echinococcus granulosus Glutaredoxin protein 5 0.0074 0.0084 0.0084
Brugia malayi Tachykinin-like peptides receptor 99D 0.0051 0.0038 0.0038
Schistosoma mansoni opsin-like receptor 0.0051 0.0038 0.0038
Echinococcus granulosus neuropeptides capa receptor 0.0051 0.0038 0.0038
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0068 0.0068
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0038 0.0038
Echinococcus multilocularis neuropeptide s receptor 0.0051 0.0038 0.0038
Brugia malayi Protein kinase domain containing protein 0.0066 0.0068 0.0068
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0051 0.0038 0.0038
Entamoeba histolytica hypothetical protein 0.0049 0.0035 0.0319
Schistosoma mansoni formin binding protein and related proteins 0.0049 0.0035 0.0035
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0039 0.0015 0.0015
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0113 0.0161 0.0161
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0051 0.0038 0.0038
Trichomonas vaginalis histone deacetylase, putative 0.0098 0.0131 0.751
Brugia malayi neuropeptide F receptor 0.0051 0.0038 0.0038
Schistosoma mansoni tyrosine kinase 0.0118 0.017 0.017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0038 0.0038
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0049 0.0035 0.0035
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0039 0.0015 0.0015
Echinococcus granulosus Protein kinase C brain isozyme 0.0039 0.0015 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0038 0.0038
Brugia malayi hypothetical protein 0.0051 0.0038 0.0038
Schistosoma mansoni tensin 0.005 0.0037 0.0037
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0051 0.0038 0.0038
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0041 0.0018 0.0018
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.005 0.0037 0.0037
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0074 0.0084 0.0084
Echinococcus multilocularis N chimaerin 0.005 0.0037 0.0037
Trypanosoma brucei histone deacetylase, putative 0.0043 0.0023 0.1329
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0076 0.0087 0.0087
Schistosoma mansoni tyrosine kinase 0.0172 0.0277 0.0277
Onchocerca volvulus 0.005 0.0037 0.5438
Loa Loa (eye worm) hypothetical protein 0.0049 0.0035 0.0035
Echinococcus multilocularis Spectrin alpha actinin 0.0049 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0037
Echinococcus multilocularis histone deacetylase 1 0.0098 0.0131 0.0131
Brugia malayi Histone deacetylase family protein 0.0043 0.0023 0.0023
Schistosoma mansoni biogenic amine (5HT) receptor 0.0051 0.0038 0.0038
Schistosoma mansoni tensin 0.005 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Loa Loa (eye worm) SH2 domain-containing protein 0.005 0.0037 0.0037
Trichomonas vaginalis p67phox protein, putative 0.0049 0.0035 0.1399
Trichomonas vaginalis histone deacetylase, putative 0.0098 0.0131 0.751
Schistosoma mansoni hypothetical protein 0.0041 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0099 0.0134 0.0134
Entamoeba histolytica histone deacetylase, putative 0.0098 0.0131 0.1899
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.0035 0.0319
Echinococcus granulosus histone deacetylase 6 0.0043 0.0023 0.0023
Echinococcus granulosus serine:threonine protein kinase N2 0.0039 0.0015 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0038 0.0038
Brugia malayi Tyrosine-protein kinase abl-1 0.0201 0.0333 0.0333
Loa Loa (eye worm) guanylate kinase 0.0049 0.0035 0.0035
Schistosoma mansoni tyrosine kinase 0.0188 0.0308 0.0308
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0068 0.0068
Schistosoma mansoni SH2A 0.005 0.0037 0.0037
Echinococcus multilocularis Glutaredoxin protein 5 0.0074 0.0084 0.0084
Loa Loa (eye worm) G-protein coupled receptor 0.0051 0.0038 0.0038
Brugia malayi Variant SH3 domain containing protein 0.0049 0.0035 0.0035
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.0035 0.0319
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0023 0.1727
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0051 0.0038 0.0038
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0448 0.0819 0.0819
Echinococcus granulosus epidermal growth factor receptor kinase 0.0049 0.0035 0.0035
Echinococcus granulosus signal transduction protein lnk realted 0.005 0.0037 0.0037
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0051 0.0038 0.0038
Toxoplasma gondii AGC kinase 0.0113 0.0161 1
Schistosoma mansoni tyrosine-protein kinase zap-70 0.005 0.0037 0.0037
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0051 0.0038 0.0038
Echinococcus multilocularis SHC transforming protein 3 0.005 0.0037 0.0037
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0038 0.0038
Echinococcus granulosus protein kinase c epsilon type 0.0039 0.0015 0.0015
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0068 0.0068
Onchocerca volvulus 0.0066 0.0068 1
Entamoeba histolytica BAR/SH3 domain containing protein 0.0049 0.0035 0.0319
Schistosoma mansoni dynamin-associated protein 0.0049 0.0035 0.0035
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0049 0.0035 0.0035
Schistosoma mansoni tensin 0.005 0.0037 0.0037
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0051 0.0038 0.0038
Trichomonas vaginalis AGC family protein kinase 0.0118 0.017 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0051 0.0038 0.0038
Schistosoma mansoni neuropeptide receptor 0.0051 0.0038 0.0038
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0051 0.0038 0.0038
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Brugia malayi larval opioid receptor 0.0051 0.0038 0.0038
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0102 0.0138 0.0138
Onchocerca volvulus 0.0066 0.0068 1
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0023 0.1727
Loa Loa (eye worm) AGC/AKT protein kinase 0.0118 0.017 0.017
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0448 0.0819 0.0819
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0038 0.0038
Schistosoma mansoni neuropeptide f receptor 76f 0.0051 0.0038 0.0038
Onchocerca volvulus 0.005 0.0037 0.5413
Echinococcus multilocularis rac serine:threonine kinase 0.008 0.0095 0.0095
Loa Loa (eye worm) AGC/NDR protein kinase 0.0039 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.0049 0.0035 0.0319
Echinococcus multilocularis 0.005 0.0037 0.0037
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0039 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.0049 0.0035 0.0319
Onchocerca volvulus 0.0051 0.0038 0.5549
Brugia malayi Protein kinase domain containing protein 0.0039 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.5119 1 1
Onchocerca volvulus 0.0066 0.0068 1
Echinococcus granulosus tyrosine kinase 0.0399 0.0723 0.0723
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0188 0.0308 0.0308
Onchocerca volvulus 0.0051 0.0038 0.5549
Onchocerca volvulus 0.0051 0.0038 0.5549
Echinococcus multilocularis tyrosine protein kinase Srms 0.0399 0.0723 0.0723
Echinococcus granulosus epidermal growth factor receptor 0.0338 0.0603 0.0603
Echinococcus multilocularis neuropeptide Y receptor 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0054 0.0043 0.0043
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Entamoeba histolytica unconventional myosin IB 0.0049 0.0035 0.0319
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0051 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0115 0.0165 0.0165
Schistosoma mansoni myosin xvIII 0.0051 0.0038 0.0038
Entamoeba histolytica protein kinase, putative 0.0113 0.0161 0.2399
Brugia malayi tRNA modification GTPase TrmE family protein 0.005 0.0037 0.0037
Echinococcus granulosus g protein coupled receptor 0.0051 0.0038 0.0038
Echinococcus granulosus SH2 domain containing protein 7 0.005 0.0037 0.0037
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.005 0.0037 0.0037
Echinococcus granulosus somatostatin receptor 0.0051 0.0038 0.0038
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.005 0.0037 0.0037
Echinococcus granulosus tensin C1 domain containing phosphatase 0.005 0.0037 0.0037
Brugia malayi putative neuropeptide receptor 0.0051 0.0038 0.0038
Echinococcus multilocularis SH2 motif 0.005 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Echinococcus multilocularis serotonin receptor 0.0051 0.0038 0.0038
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0051 0.0038 0.0038
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0049 0.0035 0.0035
Echinococcus granulosus SH2 motif 0.005 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0049 0.0035 0.0035
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0448 0.0819 0.0819
Echinococcus granulosus nervana 2 0.0074 0.0084 0.0084
Trichomonas vaginalis AGC family protein kinase 0.0118 0.017 1
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase Src42A 0.0448 0.0819 0.0819
Schistosoma mansoni growth factor receptor-bound protein 0.0099 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0038 0.0038
Schistosoma mansoni adapter molecule crk 0.0099 0.0134 0.0134
Echinococcus granulosus 7tm_1 domain containing protein 0.0051 0.0038 0.0038
Echinococcus granulosus SH2 motif 0.005 0.0037 0.0037
Echinococcus multilocularis somatostatin receptor 0.0051 0.0038 0.0038
Echinococcus granulosus epidermal growth factor receptor 0.0188 0.0308 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0035 0.1399
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0051 0.0038 0.0038
Echinococcus granulosus NDR protein kinase 0.0039 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0035 0.1399
Schistosoma mansoni tyrosine kinase 0.0188 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Echinococcus multilocularis histone deacetylase 3 0.0098 0.0131 0.0131
Schistosoma mansoni biogenic amine receptor 0.0051 0.0038 0.0038
Onchocerca volvulus Putative cortactin 0.0049 0.0035 0.5054
Loa Loa (eye worm) TK protein kinase 0.0399 0.0723 0.0723
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0038 0.0038
Onchocerca volvulus 0.0049 0.0035 0.5054
Loa Loa (eye worm) SH2 domain-containing protein 0.005 0.0037 0.0037
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0041 0.0018 0.0018
Echinococcus granulosus biogenic amine 5HT receptor 0.0051 0.0038 0.0038
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0054 0.0043 0.0043
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.5119 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0051 0.0038 0.0038
Echinococcus granulosus tensin 0.005 0.0037 0.0037
Echinococcus granulosus tyrosine protein kinase Fyn 0.0448 0.0819 0.0819
Loa Loa (eye worm) histone deacetylase 3 0.0098 0.0131 0.0131
Plasmodium vivax histone deacetylase, putative 0.0043 0.0023 0.1727
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0051 0.0038 0.0038
Plasmodium falciparum nicotinate phosphoribosyltransferase, putative 0.0078 0.0091 0.6357
Brugia malayi Protein kinase domain containing protein 0.0066 0.0068 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0038 0.0038
Echinococcus granulosus biogenic amine 5HT receptor 0.0051 0.0038 0.0038
Schistosoma mansoni tyrosine kinase 0.0115 0.0165 0.0165
Echinococcus granulosus histone deacetylase 7 0.0043 0.0023 0.0023
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0052 0.004 0.0402
Brugia malayi Variant SH3 domain containing protein 0.0049 0.0035 0.0035
Entamoeba histolytica PH domain containing protein kinase, putative 0.008 0.0095 0.1319
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0051 0.0038 0.0038
Schistosoma mansoni tyrosine kinase 0.0066 0.0068 0.0068
Onchocerca volvulus 0.005 0.0037 0.5413
Echinococcus granulosus neuropeptide receptor 0.0051 0.0038 0.0038
Trypanosoma brucei histone deacetylase 3 0.0043 0.0023 0.1329
Schistosoma mansoni amine GPCR 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0037
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0049 0.0035 0.1399
Echinococcus multilocularis serine threonine protein kinase 0.0039 0.0015 0.0015
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0015 0.0015
Echinococcus granulosus tyrosine protein kinase ABL1 0.029 0.0509 0.0509
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0039 0.0015 0.0015
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0039 0.0015 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0038 0.0038
Onchocerca volvulus 0.0051 0.0038 0.5549
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.005 0.0037 0.0037
Schistosoma mansoni nicotinate phosphoribosyltransferase related pre-B cell enhancing factor 0.042 0.0764 0.0764
Echinococcus multilocularis SH2 motif 0.005 0.0037 0.0037
Brugia malayi Myosin tail family protein 0.0049 0.0035 0.0035
Trypanosoma cruzi rac serine-threonine kinase, putative 0.008 0.0095 0.7302
Entamoeba histolytica BAR/SH3 domain containing protein 0.0049 0.0035 0.0319
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.005 0.0037 0.5413
Schistosoma mansoni opsin-like receptor 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0035 0.1399
Onchocerca volvulus 0.0051 0.0038 0.5549
Schistosoma mansoni histone deacetylase 4 5 0.0043 0.0023 0.0023
Trichomonas vaginalis AGC family protein kinase 0.0118 0.017 1
Loa Loa (eye worm) pre-B cell enhancing factor 0.042 0.0764 0.0764
Echinococcus granulosus tyrosine protein kinase Src64B 0.0448 0.0819 0.0819
Schistosoma mansoni histone deacetylase hda2 0.0045 0.0028 0.0028
Echinococcus multilocularis tyrosine protein kinase shark 0.0066 0.0068 0.0068
Brugia malayi SH2 domain containing protein 0.005 0.0037 0.0037
Onchocerca volvulus 0.005 0.0037 0.5413
Echinococcus multilocularis protein kinase c epsilon type 0.0039 0.0015 0.0015
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.005 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0041 0.0018 0.0018
Schistosoma mansoni eps8-related protein 0.0049 0.0035 0.0035
Entamoeba histolytica protein kinase, putative 0.0118 0.017 0.2543
Echinococcus granulosus serine threonine protein kinase nrc 0.0076 0.0087 0.0087
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0015 0.0167
Schistosoma mansoni apoptosis regulator bax 0.0041 0.0018 0.0018
Brugia malayi Variant SH3 domain containing protein 0.0049 0.0035 0.0035
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0051 0.0038 0.0038
Echinococcus multilocularis endophilin A3 0.0049 0.0035 0.0035
Echinococcus multilocularis growth factor receptor bound protein 2 0.0099 0.0134 0.0134
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.005 0.0037 0.0037
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0024 0.0724
Brugia malayi histone deacetylase 3 (HD3) 0.0098 0.0131 0.0131
Loa Loa (eye worm) G-protein coupled receptor 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0035 0.1399
Echinococcus multilocularis serine:threonine protein kinase 38 0.0039 0.0015 0.0015
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0098 0.0131 0.0131
Onchocerca volvulus 0.0049 0.0035 0.5054
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0038 0.0038
Echinococcus multilocularis neuropeptide receptor A26 0.0051 0.0038 0.0038
Trypanosoma brucei nicotinate phosphoribosyltransferase, putative 0.0078 0.0091 0.5375
Echinococcus granulosus suppressor of cytokine signaling 7 0.005 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0066 0.0068 0.0068
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0015 0.0015
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0038 0.0038
Echinococcus granulosus histone deacetylase 3 0.0098 0.0131 0.0131
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0051 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0115 0.0165 0.0165
Trypanosoma cruzi Protein kinase B 0.008 0.0095 0.7302
Brugia malayi Fes/CIP4 homology domain containing protein 0.0049 0.0035 0.0035
Echinococcus granulosus nervana 2 0.0074 0.0084 0.0084
Schistosoma mansoni amine GPCR 0.0051 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase HCK 0.0349 0.0624 0.0624
Entamoeba histolytica protein kinase, putative 0.0118 0.017 0.2543
Schistosoma mansoni atypical protein kinase C 0.0039 0.0015 0.0015
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0039 0.0015 0.0015
Schistosoma mansoni histone deacetylase 0.0098 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Brugia malayi SH2 domain containing protein 0.0066 0.0068 0.0068
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0051 0.0038 0.0038
Echinococcus granulosus insulin receptor 0.0118 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0448 0.0819 0.0819
Loa Loa (eye worm) TK/INSR protein kinase 0.0118 0.017 0.017
Onchocerca volvulus 0.0051 0.0038 0.5549
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0448 0.0819 0.0819
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Trichomonas vaginalis AGC family protein kinase 0.0118 0.017 1
Brugia malayi Hr1 repeat family protein 0.0039 0.0015 0.0015
Echinococcus granulosus sex peptide receptor 0.0051 0.0038 0.0038
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0049 0.0035 0.5054
Schistosoma mansoni neuropeptide receptor 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0037
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0076 0.0087 0.6631
Brugia malayi Protein-tyrosine phosphatase containing protein 0.005 0.0037 0.0037
Brugia malayi Dopamine receptor 0.0051 0.0038 0.0038
Trichomonas vaginalis nicotinate phosphoribosyltransferase, putative 0.0078 0.0091 0.5006
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Echinococcus multilocularis signal transduction protein lnk realted 0.005 0.0037 0.0037
Schistosoma mansoni tyrosine kinase 0.0172 0.0277 0.0277
Echinococcus multilocularis epidermal growth factor receptor 0.0188 0.0308 0.0308
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0098 0.0131 0.751
Brugia malayi SH2 domain containing protein 0.005 0.0037 0.0037
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0076 0.0087 0.6631
Echinococcus granulosus allatostatin A receptor 0.0051 0.0038 0.0038
Schistosoma mansoni tensin-related 0.005 0.0037 0.0037
Echinococcus multilocularis SH2 domain containing adapter protein F 0.005 0.0037 0.0037
Schistosoma mansoni sorting nexin 0.0049 0.0035 0.0035
Trichomonas vaginalis histone deacetylase, putative 0.0098 0.0131 0.751
Echinococcus granulosus tyrosine protein kinase Fyn 0.0448 0.0819 0.0819
Echinococcus multilocularis serine:threonine protein kinase N2 0.0039 0.0015 0.0015
Echinococcus granulosus src region 0.0049 0.0035 0.0035
Echinococcus multilocularis suppressor of cytokine signaling 7 0.005 0.0037 0.0037
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0041 0.0018 0.0018
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.005 0.0037 0.0037
Echinococcus granulosus tyrosine protein kinase Lyn 0.045 0.0822 0.0822
Brugia malayi G-protein coupled receptor 0.0051 0.0038 0.0038
Schistosoma mansoni tyrosine kinase 0.0118 0.017 0.017
Echinococcus granulosus hypothetical protein 0.0051 0.0038 0.0038
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.005 0.0037 0.0037
Echinococcus granulosus neuropeptide FF receptor 2 0.0051 0.0038 0.0038
Echinococcus granulosus histone deacetylase 6 0.0043 0.0023 0.0023
Schistosoma mansoni histamine h1 receptor 0.0051 0.0038 0.0038
Trypanosoma brucei conserved protein 0.0049 0.0035 0.2035
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0038 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0015 0.0015
Brugia malayi Peripheral plasma membrane protein CASK 0.0049 0.0035 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0038 0.0038
Brugia malayi ORL1-like opioid receptor 0.0051 0.0038 0.0038
Brugia malayi STAT protein, DNA binding domain containing protein 0.005 0.0037 0.0037
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0049 0.0035 0.0035
Echinococcus multilocularis nicotinamide phosphoribosyltransferase 0.042 0.0764 0.0764
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0035 0.2645
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Echinococcus granulosus 7TM GPCR rhodopsin 0.0051 0.0038 0.0038
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0041 0.0018 0.0018
Schistosoma mansoni signal transduction protein lnk-related 0.005 0.0037 0.0037
Schistosoma mansoni tyrosine kinase 0.0448 0.0819 0.0819
Echinococcus granulosus protein kinase C gamma type 0.0039 0.0015 0.0015
Brugia malayi Variant SH3 domain containing protein 0.0055 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0037
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0068 0.0068
Loa Loa (eye worm) apoptosis regulator protein 0.0041 0.0018 0.0018
Onchocerca volvulus 0.0051 0.0038 0.5549
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0055 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0037
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0038 0.0038
Brugia malayi Histone deacetylase 1 0.0098 0.0131 0.0131
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0049 0.0035 0.0035
Loa Loa (eye worm) neuropeptide F receptor 0.0051 0.0038 0.0038
Echinococcus granulosus serine/threonine protein kinase 0.008 0.0095 0.0095
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0051 0.0038 0.0038
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0038 0.0038
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0039 0.0015 0.0015
Schistosoma mansoni neuropeptide receptor 0.0051 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0035 0.1399
Loa Loa (eye worm) SRC-1 0.0448 0.0819 0.0819
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.005 0.0037 0.0037
Onchocerca volvulus 0.0051 0.0038 0.5549
Onchocerca volvulus 0.0051 0.0038 0.5549
Brugia malayi Sex muscle abnormal protein 5 0.0099 0.0134 0.0134
Loa Loa (eye worm) RhoGAP domain-containing protein 0.005 0.0037 0.0037
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0049 0.0035 0.0035
Brugia malayi Furin-like cysteine rich region family protein 0.0338 0.0603 0.0603
Echinococcus multilocularis G protein coupled receptor 139 0.0051 0.0038 0.0038
Brugia malayi hypothetical protein 0.0051 0.0038 0.0038
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0118 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0049 0.0035 0.0035
Schistosoma mansoni biogenic amine receptor 0.0051 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0066 0.0068 0.0068
Brugia malayi hypothetical protein 0.0051 0.0038 0.0038
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0039 0.0015 0.0015
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.5119 1 1
Schistosoma mansoni tensin-related 0.005 0.0037 0.0037
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0051 0.0038 0.0038
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0399 0.0723 0.0723
Brugia malayi Variant SH3 domain containing protein 0.0099 0.0134 0.0134
Brugia malayi Serotonin receptor 0.0051 0.0038 0.0038
Trichomonas vaginalis histone deacetylase, putative 0.0098 0.0131 0.751
Loa Loa (eye worm) neuropeptide F receptor 0.0051 0.0038 0.0038
Echinococcus multilocularis serotonin receptor 0.0051 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0066 0.0068 0.0068
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0383 0.0691 0.0691
Echinococcus granulosus tyrosine kinase 0.0066 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Onchocerca volvulus 0.005 0.0037 0.5413
Trypanosoma brucei histone deacetylase 1 0.0098 0.0131 0.7694
Echinococcus granulosus expressed protein 0.0049 0.0035 0.0035
Echinococcus granulosus N chimaerin 0.005 0.0037 0.0037
Entamoeba histolytica protein kinase 2, putative 0.0076 0.0087 0.1175
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0118 0.017 0.017
Entamoeba histolytica SH2 domain containing protein 0.005 0.0037 0.0359
Brugia malayi p70 ribosomal S6 kinase beta 0.0113 0.0161 0.0161
Schistosoma mansoni run and tbc1 domain containing 0.0049 0.0035 0.0035
Echinococcus granulosus c src tyrosine kinase 0.0115 0.0165 0.0165
Schistosoma mansoni tyrosine kinase 0.0448 0.0819 0.0819
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0448 0.0819 0.0819
Brugia malayi RE15519p 0.0051 0.0038 0.0038
Schistosoma mansoni tyrosine kinase 0.0172 0.0277 0.0277
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0068 0.0068
Echinococcus granulosus fch and double sh3 domains protein 2 0.0049 0.0035 0.0035
Echinococcus multilocularis orexin receptor type 2 0.0051 0.0038 0.0038
Entamoeba histolytica PH domain containing protein kinase, putative 0.008 0.0095 0.1319
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Trypanosoma brucei rac serine-threonine kinase, putative 0.0118 0.017 1
Entamoeba histolytica protein kinase, putative 0.0349 0.0624 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0098 0.0131 1
Brugia malayi Tensin 0.005 0.0037 0.0037
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0074 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0038 0.0038
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0076 0.0087 0.0087
Echinococcus multilocularis g-protein coupled receptor 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Brugia malayi Variant SH3 domain containing protein 0.0049 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0041 0.0018 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0051 0.0038 0.0038
Echinococcus granulosus g-protein coupled receptor 0.0051 0.0038 0.0038
Plasmodium falciparum histone deacetylase 1 0.0098 0.0131 1
Echinococcus granulosus SH2 domain containing adapter protein F 0.005 0.0037 0.0037
Schistosoma mansoni growth factor receptor-bound protein 0.0099 0.0134 0.0134
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0015 0.0167
Echinococcus multilocularis tensin 0.005 0.0037 0.0037
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0448 0.0819 0.0819
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0051 0.0038 0.0038
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0041 0.0018 0.0018
Loa Loa (eye worm) TK/EGFR protein kinase 0.0338 0.0603 0.0603
Echinococcus granulosus neuropeptide receptor A26 0.0051 0.0038 0.0038
Echinococcus granulosus tyrosine protein kinase Fyn 0.0448 0.0819 0.0819
Brugia malayi Variant SH3 domain containing protein 0.0099 0.0134 0.0134
Echinococcus granulosus tm gpcr rhodopsin 0.0051 0.0038 0.0038
Brugia malayi hypothetical protein 0.0051 0.0038 0.0038
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0051 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0049 0.0035 0.0035
Brugia malayi RhoGAP domain containing protein 0.005 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Loa Loa (eye worm) TK/FER protein kinase 0.0066 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Entamoeba histolytica hypothetical protein 0.0054 0.0043 0.0463
Echinococcus multilocularis neuropeptide FF receptor 2 0.0051 0.0038 0.0038
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0448 0.0819 0.0819
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0051 0.0038 0.0038
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0049 0.0035 0.0035
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0049 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0035 0.1399
Trichomonas vaginalis AGC family protein kinase 0.0118 0.017 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0051 0.0038 0.0038
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0051 0.0038 0.0038
Schistosoma mansoni amine GPCR 0.0051 0.0038 0.0038
Schistosoma mansoni cell polarity protein 0.0049 0.0035 0.0035
Echinococcus multilocularis tyrosine protein kinase ABL1 0.029 0.0509 0.0509
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.5119 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0051 0.0038 0.0038
Onchocerca volvulus 0.0051 0.0038 0.5549
Entamoeba histolytica hypothetical protein 0.0049 0.0035 0.0319
Brugia malayi hypothetical protein 0.005 0.0037 0.0037
Echinococcus granulosus nostrin 0.0049 0.0035 0.0035
Brugia malayi Tyrosine-protein kinase abl-1 0.0138 0.021 0.021
Echinococcus granulosus g protein coupled receptor 0.0051 0.0038 0.0038
Brugia malayi GnHR receptor homolog 0.0051 0.0038 0.0038
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0049 0.0035 0.0035
Schistosoma mansoni growth hormone secretagogue receptor 0.0051 0.0038 0.0038
Trypanosoma brucei histone deacetylase 4 0.0043 0.0023 0.1329
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0037
Schistosoma mansoni vav2 0.0055 0.0046 0.0046
Entamoeba histolytica hypothetical protein 0.0049 0.0035 0.0319
Onchocerca volvulus 0.005 0.0037 0.5413
Schistosoma mansoni amine GPCR 0.0051 0.0038 0.0038
Brugia malayi protein-tyrosine kinase 0.0399 0.0723 0.0723
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.005 0.0037 0.0037
Echinococcus multilocularis tyrosine protein kinase HCK 0.0349 0.0624 0.0624
Echinococcus multilocularis neuropeptide receptor 0.0051 0.0038 0.0038
Schistosoma mansoni tyrosine kinase 0.0115 0.0165 0.0165
Echinococcus granulosus NCK adaptor protein 0.0099 0.0134 0.0134
Echinococcus multilocularis c src tyrosine kinase 0.0115 0.0165 0.0165
Schistosoma mansoni histone deacetylase 0.0098 0.0131 0.0131
Echinococcus granulosus endophilin A3 0.0049 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0015 0.0015
Echinococcus multilocularis g protein coupled receptor 0.0051 0.0038 0.0038
Onchocerca volvulus 0.0051 0.0038 0.5549
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0038 0.0038
Schistosoma mansoni histone deacetylase 4 5 0.0043 0.0023 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0051 0.0038 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0051 0.0038 0.0038
Schistosoma mansoni shc transforming protein 0.005 0.0037 0.0037
Echinococcus granulosus neuropeptide receptor 0.0051 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0049 0.0035 0.0035
Onchocerca volvulus 0.0066 0.0068 1
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0054 0.0043 0.0043
Schistosoma mansoni suppressor of cytokine signaling 0.005 0.0037 0.0037
Echinococcus multilocularis suppressor of cytokine signaling 7 0.005 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0051 0.0038 0.0038
Brugia malayi cytokine inducible SH2-containing protein 5 0.005 0.0037 0.0037
Echinococcus granulosus protein kinase c iota type 0.0039 0.0015 0.0015
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0015 0.0015
Echinococcus multilocularis SH2 motif 0.005 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0049 0.0035 0.0035
Echinococcus multilocularis suppressor of cytokine signaling 6 0.005 0.0037 0.0037
Echinococcus granulosus hypothetical protein 0.005 0.0037 0.0037
Schistosoma mansoni GTPase activating protein 0.005 0.0037 0.0037

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.00024 uM Cytotoxic activity of the compound against human epidermoid carcinoma cells (KB) ChEMBL. 10780917
EC50 (functional) < 0.00025 uM Cytotoxic activity against mouse lymphocytic leukemia cells (L1210) ChEMBL. 10780917
EC50 (functional) < 0.0004 uM Cytotoxic activity against mouse lymphocytic leukemia cells (L1210) ChEMBL. 10780917
EC50 (functional) = 0.016 uM Cytotoxic activity against african green monkey (C. aethiops) kidney epithelial cells (VERO) ChEMBL. 10780917

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 10780917

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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