Detailed information for compound 58243

Basic information

Technical information
  • TDR Targets ID: 58243
  • Name: 2-(3,4-dichlorophenyl)-6-methylsulfinyl-3,4-d ihydro-2H-pyrano[2,3-b]pyridine
  • MW: 342.24 | Formula: C15H13Cl2NO2S
  • H donors: 0 H acceptors: 2 LogP: 4.29 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cc(ccc1Cl)C1CCc2c(O1)ncc(c2)[S+](C)[O-]
  • InChi: 1S/C15H13Cl2NO2S/c1-21(19)11-6-10-3-5-14(20-15(10)18-8-11)9-2-4-12(16)13(17)7-9/h2,4,6-8,14H,3,5H2,1H3
  • InChiKey: MYBDTGDPCIIJEQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 102830-70-6
  • 2H-Pyrano[2,3-b]pyridine, 2-(3,4-dichlorophenyl)-3,4-dihydro-6-(methylsulfinyl)-
  • 2H-Pyrano(2,3-b)pyridine, 2-(3,4-dichlorophenyl)-3,4-dihydro-6-(methylsulfinyl)-
  • AIDS190898
  • AIDS-190898

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans Type I modular polyketide synthase 0.0055 0.0029 0.2651
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1543 0.1555 1
Schistosoma mansoni egf-like domain protein 0.004 0.0014 0.0023
Loa Loa (eye worm) integrin beta-2 0.9776 1 1
Brugia malayi Subtilase family protein 0.0108 0.0084 0.007
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1508 0.152 0.152
Giardia lamblia Furin precursor putative serine protease 0.0491 0.0477 0.3806
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0599 0.0588 0.3423
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0055 0.0029 0.2651
Schistosoma mansoni hypothetical protein 0.0056 0.003 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0491 0.0477 0.2667
Echinococcus granulosus membrane bound transcription factor site 1 0.0108 0.0084 0.0095
Loa Loa (eye worm) hypothetical protein 0.0097 0.0072 0.0072
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0108 0.0084 0.0095
Schistosoma mansoni site-1 peptidase (S08 family) 0.0108 0.0084 0.0143
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0115 0.0091 1
Echinococcus multilocularis membrane bound transcription factor site 1 0.0108 0.0084 0.0095
Mycobacterium ulcerans polyketide synthase 0.0058 0.0032 0.3137
Mycobacterium ulcerans Type I modular polyketide synthase 0.0055 0.0029 0.2651
Mycobacterium tuberculosis Probable thioesterase TesA 0.0048 0.0022 0.2007
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0491 0.0477 0.2667
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0028 0.0014
Brugia malayi hypothetical protein 0.0306 0.0286 0.0272
Toxoplasma gondii subtilisin SUB8 0.0108 0.0084 0.4316
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0114 0.009 0.0152
Loa Loa (eye worm) hypothetical protein 0.0065 0.0039 0.0039
Echinococcus granulosus integrin alpha ps 0.0423 0.0406 0.0533
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0599 0.0588 0.3423
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0129 0.0105 0.0124
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0234 0.0212 0.0363
Schistosoma mansoni protein kinase 0.0129 0.0105 0.018
Mycobacterium ulcerans Type I modular polyketide synthase 0.0055 0.0029 0.2651
Brugia malayi EGF-like domain containing protein 0.0213 0.0191 0.0177
Loa Loa (eye worm) hypothetical protein 0.004 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0491 0.0477 0.2667
Brugia malayi EGF-like domain containing protein 0.0213 0.0191 0.0177
Onchocerca volvulus 0.0107 0.0082 0.3846
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0083 0.0058 0.6632
Trichomonas vaginalis conserved hypothetical protein 0.0491 0.0477 0.2667
Loa Loa (eye worm) hypothetical protein 0.0213 0.0191 0.0191
Mycobacterium ulcerans polyketide synthase 0.0055 0.0029 0.2651
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0115 0.0091 1
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0108 0.0084 0.0095
Schistosoma mansoni protein kinase 0.0129 0.0105 0.018
Loa Loa (eye worm) hypothetical protein 0.0056 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0107 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0094 0.0069 0.0069
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0056 0.003 0.0051
Mycobacterium leprae Probable polyketide synthase Pks1 0.0058 0.0032 0.3137
Brugia malayi EGF-like domain containing protein 0.0213 0.0191 0.0177
Plasmodium falciparum subtilisin-like protease 1 0.0108 0.0084 0.5
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0108 0.0084 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0599 0.0588 0.3423
Schistosoma mansoni hypothetical protein 0.0056 0.003 0.0051
Loa Loa (eye worm) hypothetical protein 0.1501 0.1513 0.1513
Brugia malayi metalloprotease 0.0065 0.0039 0.0025
Brugia malayi proprotein convertase 2 0.1595 0.1609 0.1597
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0058 0.0032 0.3137
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0108 0.0084 1
Loa Loa (eye worm) integrin alpha pat-2 0.2528 0.2565 0.2565
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0048 0.0022 0.1746
Loa Loa (eye worm) hypothetical protein 0.0108 0.0084 0.0084
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0599 0.0588 0.3423
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.1543 0.1555 0.2094
Plasmodium falciparum subtilisin-like protease 3 0.0108 0.0084 0.5
Toxoplasma gondii subtilisin SUB4 0.0108 0.0084 0.4316
Brugia malayi angiogenesis inhibito 0.0137 0.0113 0.0099
Echinococcus multilocularis integrin alpha ps 0.0882 0.0877 0.1172
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0113 0.0089 0.0089
Echinococcus multilocularis 0.2047 0.2073 0.2797
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0108 0.0084 1
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0108 0.0084 1
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0047 0.0021 0.0036
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0129 0.0105 0.0124
Onchocerca volvulus 0.0091 0.0066 0.2905
Loa Loa (eye worm) hypothetical protein 0.0107 0.0082 0.0082
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0703 0.0694 0.0924
Mycobacterium ulcerans polyketide synthase Pks13 0.0083 0.0058 0.6522
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0097 0.0072 0.0079
Schistosoma mansoni integrin alpha 0.1768 0.1787 0.3062
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0108 0.0084 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.0113 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0491 0.0477 0.2667
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0037 0.0011 0.0447
Loa Loa (eye worm) hypothetical protein 0.0064 0.0038 0.0038
Echinococcus multilocularis disintegrin and metalloproteinase 0.0097 0.0072 0.0079
Brugia malayi celfurPC protein 0.2047 0.2073 0.2062
Brugia malayi hypothetical protein 0.1501 0.1513 0.1501
Brugia malayi Integrin alpha pat-2 precursor 0.1768 0.1787 0.1775
Toxoplasma gondii hypothetical protein 0.0213 0.0191 1
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0213 0.0191 0.0729
Schistosoma mansoni furin-1 (S08 family) 0.1104 0.1105 0.1894
Brugia malayi Reprolysin 0.0137 0.0113 0.0099
Echinococcus granulosus adam 17 protease 0.0097 0.0072 0.0079
Brugia malayi Disintegrin family protein 0.0097 0.0072 0.0058
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0058 0.0032 0.3355
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0491 0.0477 0.2667
Toxoplasma gondii type I fatty acid synthase, putative 0.0041 0.0015 0.0645
Brugia malayi ADAM-TS Spacer 1 family protein 0.0137 0.0113 0.0099
Loa Loa (eye worm) hypothetical protein 0.0072 0.0047 0.0047
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0056 0.003 0.0022
Schistosoma mansoni biogenic amine (5HT) receptor 0.0145 0.0121 0.0207
Echinococcus multilocularis integrin alpha ps 0.0423 0.0406 0.0533
Loa Loa (eye worm) hypothetical protein 0.004 0.0014 0.0014
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0108 0.0084 0.0143
Onchocerca volvulus 0.01 0.0075 0.3454
Toxoplasma gondii subtilisin SUB6 0.0108 0.0084 0.4316
Loa Loa (eye worm) hypothetical protein 0.0137 0.0113 0.0113
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0107 0.0082 0.014
Echinococcus granulosus integrin alpha 3 0.1309 0.1316 0.1769
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0058 0.0032 0.3355
Brugia malayi ADAMTS-like protease 0.0137 0.0113 0.0099
Echinococcus granulosus Furin 1 0.0599 0.0588 0.0779
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.004 0.0014 0.0014
Onchocerca volvulus Fatty acid synthase homolog 0.0104 0.0079 0.3661
Trichomonas vaginalis conserved hypothetical protein 0.0491 0.0477 0.2667
Echinococcus granulosus adam 0.0519 0.0505 0.0667
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0599 0.0588 0.1007
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0058 0.0032 0.3355
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0058 0.0032 0.3137
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0234 0.0212 0.0363
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0056 0.003 0.3038
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0055 0.0029 0.2884
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0108 0.0084 1
Plasmodium falciparum subtilisin-like protease 2 0.0108 0.0084 0.5
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0055 0.0029 0.2651
Loa Loa (eye worm) hypothetical protein 0.0213 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0213 0.0191 0.0191
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0108 0.0084 0.0143
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0108 0.0084 0.007
Loa Loa (eye worm) angiogenesis inhibito 0.0065 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0486 0.0472 0.0472
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0491 0.0477 0.2667
Schistosoma mansoni integrin alpha-ps 0.0882 0.0877 0.1503
Schistosoma mansoni apoptosis regulator bax 0.0056 0.003 0.0051
Toxoplasma gondii subtilisin SUB12 0.0108 0.0084 0.4316
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.1543 0.1555 0.2094
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0599 0.0588 0.3423
Trichomonas vaginalis conserved hypothetical protein 0.0491 0.0477 0.2667
Loa Loa (eye worm) apoptosis regulator protein 0.0056 0.003 0.003
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0108 0.0084 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1543 0.1555 1
Brugia malayi Trypsin family protein 0.0107 0.0082 0.0068
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0599 0.0588 0.3423
Trichomonas vaginalis conserved hypothetical protein 0.0491 0.0477 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0491 0.0477 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0491 0.0477 0.2667
Trichomonas vaginalis conserved hypothetical protein 0.0491 0.0477 0.2667
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0113 0.0089 0.0075
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0047 0.0021 0.0021
Plasmodium vivax subtilisin-like protease 2, putative 0.0108 0.0084 0.5
Loa Loa (eye worm) endoprotease bli-4 0.2538 0.2576 0.2576
Mycobacterium ulcerans thioesterase 0.0048 0.0022 0.1746
Echinococcus multilocularis integrin alpha ps 0.0945 0.0942 0.1261
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0003
Echinococcus multilocularis serotonin receptor 0.0145 0.0121 0.0145
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0041 0.0015 0.1136
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0055 0.0029 0.2884
Trichomonas vaginalis hypothetical protein 0.0213 0.0191 0.0729
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0083 0.0058 0.6632
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0097 0.0072 0.0079
Loa Loa (eye worm) hypothetical protein 0.1246 0.1251 0.1251
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0055 0.0029 0.2651
Echinococcus granulosus integrin alpha ps 0.0945 0.0942 0.1261
Brugia malayi Kelch motif family protein 0.1508 0.152 0.1508
Echinococcus granulosus integrin beta 2 0.7215 0.7373 1
Loa Loa (eye worm) proprotein convertase 2 0.0599 0.0588 0.0588
Toxoplasma gondii subtilisin SUB1 0.0108 0.0084 0.4316
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1246 0.1251 0.1238
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0054 0.0028 0.2772
Echinococcus multilocularis Furin 1 0.0599 0.0588 0.0779
Giardia lamblia High cysteine membrane protein Group 2 0.0943 0.094 1
Echinococcus granulosus furin 0.2538 0.2576 0.3482
Onchocerca volvulus 0.0213 0.0191 1
Toxoplasma gondii subtilisin SUB9 0.0108 0.0084 0.4316
Echinococcus multilocularis neuroendocrine convertase 2 0.1595 0.1609 0.2167
Loa Loa (eye worm) subtilase 0.0108 0.0084 0.0084
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0043 0.0017 0.1122
Echinococcus granulosus biogenic amine 5HT receptor 0.0145 0.0121 0.0145
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.2538 0.2576 0.4416
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0044 0.0018 0.1503
Loa Loa (eye worm) fatty acid synthase 0.0057 0.0031 0.0031
Echinococcus multilocularis integrin beta 2 0.7215 0.7373 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.004 0.0014 0.0615
Brugia malayi endoprotease bli-4 precursor 0.2538 0.2576 0.2566
Trichomonas vaginalis conserved hypothetical protein 0.0491 0.0477 0.2667
Schistosoma mansoni integrin beta subunit 0.5713 0.5833 1
Mycobacterium leprae Possible secreted protease 0.0108 0.0084 1
Schistosoma mansoni protein kinase 0.0129 0.0105 0.018
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0106 0.0082 0.0067
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0056 0.003 0.0016
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0043 0.0017 0.1122
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0054 0.0028 0.0028
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0058 0.0032 0.3137
Toxoplasma gondii calcium binding egf domain-containing protein 0.004 0.0014 0.0615
Loa Loa (eye worm) metalloprotease 0.0065 0.0039 0.0039
Toxoplasma gondii subtilisin SUB11 0.0108 0.0084 0.4316
Echinococcus granulosus Tolloid protein 1 0.0047 0.0021 0.001
Echinococcus multilocularis integrin alpha 3 0.1309 0.1316 0.1769
Loa Loa (eye worm) hypothetical protein 0.004 0.0014 0.0014
Echinococcus multilocularis fibrillin 1 0.0253 0.0233 0.0297
Toxoplasma gondii subtilisin SUB5 0.0108 0.0084 0.4316
Echinococcus granulosus fibrillin 2 0.0213 0.0191 0.0241
Schistosoma mansoni hypothetical protein 0.0056 0.003 0.0051
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0234 0.0212 0.0269
Schistosoma mansoni integrin alpha-ps 0.0523 0.0509 0.0872
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0306 0.0286 0.049
Loa Loa (eye worm) hypothetical protein 0.1346 0.1353 0.1353
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0108 0.0084 1
Leishmania major subtilisin-like serine peptidase 0.0108 0.0084 0.5
Loa Loa (eye worm) hypothetical protein 0.0145 0.0121 0.0121
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0115 0.0091 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0213 0.0191 0.0191
Onchocerca volvulus 0.0054 0.0028 0.0772
Loa Loa (eye worm) hypothetical protein 0.0234 0.0212 0.0212
Loa Loa (eye worm) reprolysin 0.0234 0.0212 0.0212
Echinococcus multilocularis protein jagged 2 0.0213 0.0191 0.0241
Echinococcus granulosus fibrillin 1 0.0213 0.0191 0.0241
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0043 0.0017 0.1122
Onchocerca volvulus 0.0108 0.0084 0.3944
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0056 0.003 0.0022
Toxoplasma gondii subtilisin SUB2 0.0108 0.0084 0.4316
Schistosoma mansoni hypothetical protein 0.0423 0.0406 0.0696
Schistosoma mansoni dihydroceramide desaturase 0.0097 0.0072 0.0123
Loa Loa (eye worm) hypothetical protein 0.0047 0.0021 0.0021
Toxoplasma gondii subtilisin SUB7 0.0108 0.0084 0.4316
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0058 0.0032 0.3137
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.004 0.0014 0.0014
Plasmodium vivax subtilisin-like protease 1 0.0108 0.0084 0.5
Mycobacterium leprae Polyketide synthase Pks13 0.0083 0.0058 0.6522
Trichomonas vaginalis hypothetical protein 0.0491 0.0477 0.2667
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0108 0.0084 1
Loa Loa (eye worm) hypothetical protein 0.0887 0.0882 0.0882
Echinococcus multilocularis fibrillin 2 0.0213 0.0191 0.0241
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0065 0.0039 0.0066
Schistosoma mansoni site-1 peptidase (S08 family) 0.0108 0.0084 0.0143
Echinococcus granulosus neuroendocrine convertase 2 0.1595 0.1609 0.2167
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0108 0.0084 0.007
Schistosoma mansoni hypothetical protein 0.0491 0.0477 0.0816
Echinococcus multilocularis adam 0.0519 0.0505 0.0667
Mycobacterium ulcerans thioesterase TesA 0.0048 0.0022 0.1746
Loa Loa (eye worm) hypothetical protein 0.0996 0.0994 0.0994
Echinococcus multilocularis Tolloid protein 1 0.0047 0.0021 0.001
Loa Loa (eye worm) hypothetical protein 0.0145 0.0121 0.0121
Plasmodium vivax subtilisin-like serine protease, putative 0.0108 0.0084 0.5
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0055 0.0029 0.0015
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0055 0.0029 0.2884
Echinococcus granulosus disintegrin and metalloproteinase 0.0097 0.0072 0.0079
Loa Loa (eye worm) hypothetical protein 0.0523 0.0509 0.0509
Toxoplasma gondii type I fatty acid synthase, putative 0.0058 0.0032 0.1579
Brugia malayi neuroendocrine convertase 1 precursor 0.1595 0.1609 0.1597
Loa Loa (eye worm) hypothetical protein 0.2538 0.2576 0.2576
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0056 0.003 0.3038
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0234 0.0212 0.0269
Echinococcus multilocularis serotonin receptor 0.0145 0.0121 0.0145
Toxoplasma gondii subtilisin SUB10 0.0108 0.0084 0.4316
Brugia malayi EGF-like domain containing protein 0.0213 0.0191 0.0177
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0703 0.0694 0.0924

Activities

Activity type Activity value Assay description Source Reference
CGI (functional) 0 uM Lowest concentration at which the effect on HeLa cell colony formation became apparent; d denotes Not tested ChEMBL. 3018241
ID50 (functional) = 0.009 uM Concentration required to reduce Rhino virus type 64 induced plaque formation in HeLa cell culture to 50% of control ChEMBL. 3018241
ID50 (functional) = 0.03 uM Concentration required to reduce Rhino virus type 9 induced plaque formation in HeLa cell culture to 50% of control ChEMBL. 3018241
ID50 (functional) = 0.26 uM Concentration required to reduce Rhino virus type 1A induced plaque formation in HeLa cell culture to 50% of control ChEMBL. 3018241

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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