Detailed information for compound 583035

Basic information

Technical information
  • TDR Targets ID: 583035
  • Name: (2,5-dioxopyrrolidin-1-yl) 5-(2-hydroxyethoxy )-4-oxo-pentanoate
  • MW: 273.239 | Formula: C11H15NO7
  • H donors: 1 H acceptors: 5 LogP: -1.98 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCOCC(=O)CCC(=O)ON1C(=O)CCC1=O
  • InChi: 1S/C11H15NO7/c13-5-6-18-7-8(14)1-4-11(17)19-12-9(15)2-3-10(12)16/h13H,1-7H2
  • InChiKey: OVPTZXRXNNJKSJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-(2-hydroxyethoxy)-4-oxopentanoic acid (2,5-dioxo-1-pyrrolidinyl) ester
  • 5-(2-hydroxyethoxy)-4-keto-valeric acid succinimido ester
  • (2,5-dioxopyrrolidin-1-yl) 5-(2-hydroxyethoxy)-4-oxopentanoate
  • methoxypolyethylene glycol succinimidylsuccinate
  • 78274-32-5
  • ss-Peg
  • Poly(oxy-1,2-ethanediyl), alpha-(4-((2,5-dioxo-1-pyrrolidinyl)oxy)-1,4-dioxobutyl)-omega-methoxy

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cpg binding protein 0.0031 0.0268 0.0595
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0137 0.0236
Loa Loa (eye worm) hypothetical protein 0.0027 0.0219 0.0395
Brugia malayi Sphingomyelin synthase-related 1 0.0024 0.0185 0.0322
Schistosoma mansoni nuclear hormone receptor 0.002 0.0137 0.0298
Schistosoma mansoni ap endonuclease 0.0039 0.0372 0.0831
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0042 0.008
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0247 0.0446
Brugia malayi hypothetical protein 0.0076 0.0816 0.1461
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0395 0.0086
Trichomonas vaginalis esterase, putative 0.0041 0.0395 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.002 0.0025
Brugia malayi Muscleblind-like protein 0.0149 0.1721 0.3093
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0289 0.3436 0.3436
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0082
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0042 0.008
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0024 0.0185 0.3203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0137 0.0247
Brugia malayi intermediate filament protein 0.0027 0.0225 0.0395
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0097 0.0206
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0037
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0185 0.4048
Echinococcus multilocularis expressed protein 0.0012 0.0042 0.0042
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0097 0.0174
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0006 0.0011
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0395 1
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0185 0.4048
Schistosoma mansoni hypothetical protein 0.0036 0.0327 0.0729
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0289 0.3436 0.7806
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.002 0.0025
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0289 0.3436 0.619
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0042 0.0094
Loa Loa (eye worm) hypothetical protein 0.0041 0.0395 0.0712
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0024 0.0185 0.0322
Brugia malayi hypothetical protein 0.0011 0.002 0.0025
Entamoeba histolytica hypothetical membrane-spanning protein 0.0024 0.0185 0.1848
Schistosoma mansoni hypothetical protein 0.0368 0.4402 1
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0185 0.295
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0137 0.0236
Echinococcus multilocularis lamin 0.0027 0.0225 0.0225
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0137 0.288
Echinococcus granulosus phd:f box containing protein 0.0017 0.0097 0.022
Brugia malayi jmjC domain containing protein 0.0065 0.0687 0.1229
Entamoeba histolytica hypothetical protein 0.0024 0.0185 0.1848
Loa Loa (eye worm) hypothetical protein 0.0041 0.0395 0.0712
Schistosoma mansoni ets-related 0.024 0.2832 0.6428
Toxoplasma gondii hypothetical protein 0.0024 0.0185 0.187
Echinococcus multilocularis survival motor neuron protein 1 0.0228 0.2694 0.2694
Entamoeba histolytica hypothetical protein 0.0024 0.0185 0.1848
Brugia malayi hypothetical protein 0.0011 0.002 0.0025
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.003 0.0068
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.002 0.0137 0.0247
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0006 0.0014
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.003 0.0054
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0117 0.0266
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0225 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0185 0.4048
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.003 0.0054
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0036 0.0327 0.0589
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0097 0.0174
Brugia malayi ecdysteroid receptor 0.002 0.0137 0.0236
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0037
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0816 0.1842
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0137 0.0247
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0137 0.0312
Loa Loa (eye worm) hypothetical protein 0.0024 0.0185 0.0333
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0395 0.0086
Mycobacterium tuberculosis Conserved protein 0.0041 0.0395 0.0086
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0185 0.4048
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0012 0.0042 0.0075
Loa Loa (eye worm) DR-78 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0174
Plasmodium vivax sphingomyelin synthase 2, putative 0.0024 0.0185 0.295
Brugia malayi Ets-domain containing protein 0.0079 0.0858 0.1537
Loa Loa (eye worm) hypothetical protein 0.002 0.0137 0.0247
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0372 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0113 0.1272 0.2283
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0225 0.0395
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0042 0.008
Onchocerca volvulus 0.0027 0.0225 0.4819
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0687 0.155
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0012 0.0042 0.0075
Echinococcus multilocularis musashi 0.0027 0.0225 0.0225
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0077 0.0835 0.1885
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0289 0.3436 0.7802
Schistosoma mansoni lamin 0.0027 0.0225 0.0499
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0137 0.0298
Schistosoma mansoni lamin 0.0027 0.0225 0.0499
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0012 0.0042 0.008
Schistosoma mansoni hypothetical protein 0.0036 0.0327 0.0729
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0137 0.0236
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0395 0.0086
Brugia malayi Ets-domain containing protein 0.0079 0.0858 0.1537
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.003 0.0068
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0395 0.0086
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0395 0.0701
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0649 0.1462
Brugia malayi Cytochrome P450 family protein 0.0023 0.0167 0.029
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0137 0.0236
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0097 0.0097
Echinococcus granulosus sphingomyelin synthase protein 1 0.0024 0.0185 0.042
Loa Loa (eye worm) hypothetical protein 0.0149 0.1721 0.3101
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0069 0.0114
Onchocerca volvulus 0.0012 0.0042 0.0777
Entamoeba histolytica hypothetical protein 0.0076 0.0816 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0372 0.921
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0097 0.0097
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0137 0.0236
Loa Loa (eye worm) hypothetical protein 0.0024 0.0185 0.0333
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0137 0.0236
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0137 0.0298
Brugia malayi transcription factor E74 isoform 0.0011 0.003 0.0043
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0395 0.0712
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0097 0.022
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Brugia malayi nuclear receptor NHR-88 0.002 0.0137 0.0236
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0054
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0051 0.0051
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0012 0.0042 0.0064
Loa Loa (eye worm) beta-lactamase 0.0041 0.0395 0.0712
Brugia malayi nuclear hormone receptor 0.002 0.0137 0.0236
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0225 0.0406
Echinococcus granulosus expressed protein 0.0012 0.0042 0.0094
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0185 0.0322
Echinococcus multilocularis lamin dm0 0.0027 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.002 0.0137 0.0247
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0012 0.0042 0.0064
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0068 0.0718 0.1293
Brugia malayi latrophilin 2 splice variant baaae 0.0077 0.0835 0.1494
Echinococcus granulosus lamin 0.0027 0.0225 0.0512
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0858 0.195
Mycobacterium ulcerans hypothetical protein 0.0041 0.0395 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0225 0.0499
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Brugia malayi steroid hormone receptor 0.002 0.0137 0.0236
Loa Loa (eye worm) hypothetical protein 0.002 0.0137 0.0247
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0024 0.0185 0.3203
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0289 0.3436 0.3436
Schistosoma mansoni ap endonuclease 0.0039 0.0372 0.0831
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0372 0.9333
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0667 0.0667
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0289 0.3436 0.6186
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0097 0.0097
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0185 0.295
Loa Loa (eye worm) hypothetical protein 0.0461 0.5551 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.002 0.0137 0.0247
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.003 0.0054
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0568 1
Schistosoma mansoni gabp alpha 0.0079 0.0858 0.1939
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0137 0.0236
Mycobacterium tuberculosis Conserved protein 0.0041 0.0395 0.0086
Schistosoma mansoni hypothetical protein 0.0036 0.0327 0.0729
Brugia malayi Ets-domain containing protein 0.0011 0.003 0.0043
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.003 0.0054
Echinococcus granulosus lamin dm0 0.0027 0.0225 0.0512
Loa Loa (eye worm) hypothetical protein 0.002 0.0137 0.0247
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0037
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0006 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0395 1
Schistosoma mansoni ets-related 0.0011 0.003 0.0054
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0137 0.0247
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0042 0.008
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0137 0.288
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0289 0.3436 0.7806
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0013 0.0045 0.0082
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.003 0.003
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.003 0.003
Entamoeba histolytica hypothetical protein 0.0076 0.0816 1
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0858 0.0858
Mycobacterium leprae Probable lipase LipE 0.0041 0.0395 0.5
Echinococcus granulosus intermediate filament protein 0.0027 0.0225 0.0512
Schistosoma mansoni coup transcription factor 0.002 0.0137 0.0298
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0372 0.426
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0042 0.0094
Echinococcus granulosus survival motor neuron protein 1 0.0228 0.2694 0.6118
Brugia malayi G-protein alpha subunit 0.0012 0.0042 0.0064
Onchocerca volvulus 0.0027 0.0225 0.4819
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0042 0.0042
Entamoeba histolytica hypothetical protein 0.0076 0.0816 1
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0395 0.0086
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0185 0.0322
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0137 0.0298
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0395 0.0898
Brugia malayi jmjC domain containing protein 0.0017 0.0097 0.0163
Onchocerca volvulus 0.0012 0.0042 0.0777
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0395 0.0086
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0137 0.0137
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0372 0.921
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Echinococcus multilocularis GPCR, family 2 0.0036 0.0327 0.0327
Echinococcus granulosus GPCR family 2 0.0036 0.0327 0.0742
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0372 0.5
Trypanosoma brucei inositol phosphorylceramide synthase 0.0024 0.0185 0.295
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0461 0.5551 1
Mycobacterium tuberculosis Conserved protein 0.0041 0.0395 0.0086
Mycobacterium ulcerans beta-lactamase 0.0041 0.0395 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0395 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0137 0.0312
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0372 0.0372
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0327 0.0742
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0289 0.3436 0.7802
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0042 0.0094
Schistosoma mansoni hypothetical protein 0.0011 0.003 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0289 0.3436 0.7802
Brugia malayi CXXC zinc finger family protein 0.0029 0.0247 0.0435
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0137 0.0298
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0687 0.1562
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0395 1
Echinococcus multilocularis protein C ets 2 0.0011 0.003 0.003
Brugia malayi beta-lactamase family protein 0.0041 0.0395 0.0701
Loa Loa (eye worm) hypothetical protein 0.002 0.0137 0.0247
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0327 0.0327
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0051 0.0117
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0042 0.008
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0137 0.0312
Echinococcus granulosus FTZ F1 alpha 0.002 0.0137 0.0312
Schistosoma mansoni ets 0.0011 0.003 0.0054
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0097 0.0206
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0097 0.022
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0037
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0327 0.0589
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0012 0.0042 0.0075
Onchocerca volvulus 0.0029 0.0247 0.5299
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0137 0.0137
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0137 0.0312
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0042 0.008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0137 0.0312
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0174
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0185 0.295
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0137 0.0236
Schistosoma mansoni spingomyelin synthetase-related 0.0024 0.0185 0.0406
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0042 0.008
Schistosoma mansoni hypothetical protein 0.0036 0.0327 0.0729
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0372 0.921
Echinococcus granulosus muscleblind protein 0.0149 0.1721 0.391
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0395 1
Brugia malayi jmjC domain containing protein 0.0063 0.0667 0.1192
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0185 0.4048
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0042 0.0094
Onchocerca volvulus 0.0041 0.0395 0.8548
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0395 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.002 0.0037
Loa Loa (eye worm) hypothetical protein 0.0077 0.0835 0.1504
Onchocerca volvulus 0.002 0.0137 0.288
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0395 1
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0185 0.295
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0395 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.0395 0.0712
Brugia malayi nuclear receptor RXR 0.0011 0.002 0.0025
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0137 0.0312
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0395 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0137 0.0236
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0012 0.0042 0.008
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0012 0.0042 0.0075
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0041 0.0395 0.0712
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0012 0.0042 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0075
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0372 0.921
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0167 0.0301
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0327 0.0742
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0113 0.1272 0.2292
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0816 0.0816
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0097 0.0174
Schistosoma mansoni hypothetical protein 0.0076 0.0816 0.1842
Brugia malayi beta-lactamase 0.0041 0.0395 0.0701
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0372 0.0659
Schistosoma mansoni survival motor neuron protein 0.0047 0.0461 0.1035
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0137 0.0298
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0137 0.0247
Loa Loa (eye worm) hypothetical protein 0.0011 0.002 0.0037
Loa Loa (eye worm) hypothetical protein 0.0041 0.0395 0.0712
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0012 0.0042 0.0042
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0327 0.0327
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0042 0.0064
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0024 0.0185 0.0185
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0097 0.0206
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0395 0.0712
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0137 0.0298
Loa Loa (eye worm) G protein alpha subunit 3 0.0012 0.0042 0.0075
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0012 0.0042 0.0094
Onchocerca volvulus 0.0041 0.0395 0.8548
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0137 0.0236
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0395 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0687 0.155
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0075
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.003 0.0068
Schistosoma mansoni elf1 0.0011 0.003 0.0054
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0012 0.0042 0.0064
Brugia malayi hypothetical protein 0.0228 0.2694 0.4847
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0372 1
Schistosoma mansoni cpg binding protein 0.0029 0.0247 0.0548
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0137 0.0312
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0395 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.1721 0.3101
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0042 0.008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0137 0.0236
Onchocerca volvulus 0.0012 0.0042 0.0777
Toxoplasma gondii ABC1 family protein 0.0041 0.0395 0.6338
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0372 0.5
Schistosoma mansoni thyroid hormone receptor 0.002 0.0137 0.0298
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0042 0.008
Loa Loa (eye worm) hypothetical protein 0.002 0.0137 0.0247
Loa Loa (eye worm) hypothetical protein 0.0228 0.2694 0.4852
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0042 0.0042
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0372 0.921
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0012 0.0042 0.0064
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0097 0.0206
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.002 0.0032
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0042 0.0042
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0006 0.0011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0372 0.0669
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0137 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0137 0.0236
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0137 0.0298
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0012 0.0042 0.0064
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0097 0.0206
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.0113 0.1272 0.2292
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.003 0.0068
Schistosoma mansoni hypothetical protein 0.0047 0.0461 0.1035
Plasmodium vivax sphingomyelin synthase 1, putative 0.0024 0.0185 0.295
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.003 0.003
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0137 0.0137
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0687 0.1238
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0461 0.0821
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0816 0.1854
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0137 0.0247
Echinococcus granulosus geminin 0.0368 0.4402 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0263 0.3121 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0667 0.0667
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0137 0.0137
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0051 0.0093
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0327 0.0578
Loa Loa (eye worm) hypothetical protein 0.0024 0.0185 0.0333
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0137 0.0137
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0667 0.1515
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0395 0.0086
Brugia malayi hypothetical protein 0.0012 0.0042 0.0064
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.003 0.0043
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0137 0.0236
Echinococcus multilocularis muscleblind protein 0.0149 0.1721 0.1721
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0137 0.0137
Entamoeba histolytica hypothetical protein 0.0024 0.0185 0.1848
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.003 0.0068
Entamoeba histolytica hypothetical protein 0.0076 0.0816 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0069 0.0125
Echinococcus multilocularis ets variant gene 4 0.0011 0.003 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0137 0.0247
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0137 0.288
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0667 0.1503
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0042 0.0064
Echinococcus granulosus protein C ets 2 0.0011 0.003 0.0068
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.002 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0137 0.0236
Brugia malayi jmjC domain containing protein 0.0017 0.0097 0.0163
Schistosoma mansoni hypothetical protein 0.0011 0.003 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0075
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.003 0.003
Brugia malayi Fli-1 protein 0.024 0.2832 0.5096
Echinococcus multilocularis geminin 0.0368 0.4402 0.4402
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Entamoeba histolytica hypothetical protein 0.0024 0.0185 0.1848
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0006 0.0006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0137 0.0137
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0395 0.0885
Onchocerca volvulus 0.0047 0.0461 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0185 0.0333
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.003 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0137 0.0247
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0006 0.0006
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0372 0.9333
Echinococcus multilocularis cpg binding protein 0.0031 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0027 0.0225 0.0406
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0006 0.0014
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0327 0.0578
Echinococcus multilocularis muscleblind protein 1 0.0149 0.1721 0.1721
Leishmania major hypothetical protein, conserved 0.0041 0.0395 1
Trichomonas vaginalis hypothetical protein 0.0024 0.0185 0.4048
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0137 0.0247
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.002 0.0046
Brugia malayi beta-lactamase family protein 0.0041 0.0395 0.0701
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.003 0.0054
Brugia malayi jmjC domain containing protein 0.0017 0.0097 0.0163
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0006 0.0014
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0858 0.1547
Entamoeba histolytica hypothetical protein 0.0024 0.0185 0.1848
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0395 1
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0185 0.295
Onchocerca volvulus 0.0041 0.0395 0.8548
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0006 0.0014
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0137 0.0312
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0042 0.008
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0024 0.0185 0.3203
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0042 0.0064
Loa Loa (eye worm) hypothetical protein 0.0024 0.0185 0.0333
Schistosoma mansoni hypothetical protein 0.0368 0.4402 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0075
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.0054
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0024 0.0185 0.295
Schistosoma mansoni thyroid hormone receptor 0.002 0.0137 0.0298
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0097 0.022
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0137 0.0236
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0137 0.0137
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0137 0.0298
Echinococcus granulosus cpg binding protein 0.0031 0.0268 0.0608
Brugia malayi Calcitonin receptor-like protein seb-1 0.0113 0.1272 0.2283
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0372 0.0844
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0024 0.0185 0.0322
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0097 0.0174
Loa Loa (eye worm) fli-1 protein 0.024 0.2832 0.5102
Schistosoma mansoni cpg binding protein 0.0031 0.0268 0.0595
Brugia malayi jmjC domain containing protein 0.0017 0.0097 0.0163
Toxoplasma gondii exonuclease III APE 0.0039 0.0372 0.5837
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0042 0.008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0395 0.0885
Mycobacterium ulcerans lipase LipD 0.0041 0.0395 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0137 0.0236

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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