Detailed information for compound 592413

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 684.707 | Formula: C37H35F3N6O4
  • H donors: 3 H acceptors: 7 LogP: 1.42 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.CC(=O)Nc1cccc(c1)CN(C(=O)Cc1cccnc1)Cc1ccc(cc1)c1ccc(cn1)CNCc1cccnc1
  • InChi: 1S/C35H34N6O2.C2HF3O2/c1-26(42)40-33-8-2-5-29(17-33)25-41(35(43)18-28-6-3-15-36-19-28)24-27-9-12-32(13-10-27)34-14-11-31(23-39-34)22-38-21-30-7-4-16-37-20-30;3-2(4,5)1(6)7/h2-17,19-20,23,38H,18,21-22,24-25H2,1H3,(H,40,42);(H,6,7)
  • InChiKey: SVHYFYQLQSLDRR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus General substrate transporter 0.0291 0.29 0.3927
Plasmodium falciparum protein kinase 7 0.0649 0.6616 0.6612
Loa Loa (eye worm) hypothetical protein 0.0134 0.1266 0.3728
Toxoplasma gondii transporter, major facilitator family protein 0.0048 0.0373 0.0546
Trypanosoma brucei glucose transporter, putative 0.0105 0.0969 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.046 0.1354
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0373 0.1093
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.007 0.0609 0.6273
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0069 0.0594 0.0791
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0373 0.1093
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0339 0.3395 0.46
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0516 0.0685
Toxoplasma gondii facilitative glucose transporter GT1 0.0339 0.3395 0.5122
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.007 0.0609 0.0811
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0015 0.0035 0.0022
Plasmodium vivax calcium-dependent protein kinase, putative 0.007 0.0609 0.0597
Echinococcus granulosus solute carrier family 22 0.0048 0.0373 0.049
Schistosoma mansoni tyrosine kinase 0.0077 0.0679 0.0922
Leishmania major lysyl-tRNA synthetase, putative 0.0051 0.0411 0.4226
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0024 0.0131 0.0419
Brugia malayi jmjC domain containing protein 0.0016 0.0048 0.0143
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0271 0.4428
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.007 0.0609 0.0903
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0271 0.0792
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0339 0.3395 0.46
Plasmodium falciparum lysine--tRNA ligase 0.0051 0.0411 0.0399
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0271 0.0792
Giardia lamblia Hexose transporter 0.0048 0.0373 0.6198
Toxoplasma gondii cell division protein CDC48CY 0.0028 0.0173 0.0243
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Mycobacterium tuberculosis Putative conserved ATPase 0.0017 0.0054 0.1166
Onchocerca volvulus 0.0048 0.0373 0.2058
Echinococcus multilocularis 0.0045 0.0345 0.0468
Entamoeba histolytica cdc48-like protein, putative 0.0027 0.0157 0.2564
Loa Loa (eye worm) hypothetical protein 0.0067 0.0571 0.1682
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.1098
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0033 0.0031
Onchocerca volvulus Huntingtin homolog 0.0128 0.1208 0.6991
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0013 0.0012 0.0037
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0048 0.0049
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0048 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.268 0.7894
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0048 0.0066
Onchocerca volvulus 0.0048 0.0373 0.2058
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0024 0.0232
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.007 0.0609 0.0903
Loa Loa (eye worm) hypothetical protein 0.0052 0.0419 0.1235
Echinococcus granulosus microtubule associated protein 2 0.0721 0.7366 1
Echinococcus granulosus insulin receptor 0.0046 0.036 0.0472
Schistosoma mansoni tyrosine kinase 0.0046 0.036 0.0488
Trypanosoma brucei THT1 - hexose transporter, putative 0.0105 0.0969 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0024 0.0066
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.1098
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0271 0.2778
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0339 0.3395 0.4609
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0046 0.036 0.0488
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.007 0.0609 0.1793
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.1098
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0013 0.0012 0.0108
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.1098
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0373 0.1093
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0143
Trichomonas vaginalis glucose transporter, putative 0.0048 0.0373 0.1093
Brugia malayi hypothetical protein 0.0128 0.1208 0.3557
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0024 0.0066
Loa Loa (eye worm) hypothetical protein 0.0014 0.0024 0.0072
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0609 0.0826
Onchocerca volvulus 0.0048 0.0373 0.2058
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0028 0.0173 0.0234
Loa Loa (eye worm) hypothetical protein 0.0128 0.1208 0.3557
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0069 0.0594 0.0806
Brugia malayi hypothetical protein 0.0048 0.0373 0.1098
Schistosoma mansoni microtubule-associated protein tau 0.0721 0.7366 1
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.268 0.7894
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1717 0.5054
Trypanosoma brucei glucose transporter, putative 0.0105 0.0969 1
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0069 0.0594 0.1744
Loa Loa (eye worm) hypothetical protein 0.0036 0.0248 0.0731
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0143
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0069 0.0594 0.9756
Schistosoma mansoni alpha glucosidase 0.0038 0.0271 0.0367
Trypanosoma brucei glucose transporter, putative 0.0105 0.0969 1
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0027 0.0157 0.2564
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Loa Loa (eye worm) glutaminase 0.0286 0.2844 0.8379
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.1098
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0271 0.0792
Echinococcus multilocularis GPCR, family 2 0.0016 0.0049 0.0067
Plasmodium falciparum calcium-dependent protein kinase 2 0.007 0.0609 0.0597
Echinococcus multilocularis epidermal growth factor receptor 0.0078 0.0688 0.0934
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Loa Loa (eye worm) glutaminase 2 0.0286 0.2844 0.8379
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0013 0.0012 0.0037
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.1646 0.2235
Brugia malayi major facilitator superfamily protein 0.0048 0.0373 0.1098
Schistosoma mansoni protein kinase 0.007 0.0609 0.0826
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.027 0.268 0.7896
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0048 0.0373 0.1272
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0271 0.0797
Loa Loa (eye worm) major facilitator superfamily transporter 0.0048 0.0373 0.1098
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0049 0.0146
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Schistosoma mansoni lysyl-tRNA synthetase 0.0051 0.0411 0.0557
Onchocerca volvulus Putative transporter 0.0048 0.0373 0.2058
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0271 0.0351
Brugia malayi Protein kinase domain containing protein 0.0046 0.036 0.106
Trichomonas vaginalis conserved hypothetical protein 0.0339 0.3395 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0105 0.0969 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0609 0.0826
Brugia malayi jmjC domain containing protein 0.0016 0.0048 0.0143
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0037
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0027 0.0157 0.1609
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0024 0.0066
Echinococcus granulosus bloom syndrome protein 0.0022 0.011 0.0132
Brugia malayi lysyl-tRNA synthetase 0.0051 0.0411 0.1209
Echinococcus multilocularis General substrate transporter 0.0291 0.29 0.3938
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Echinococcus granulosus calcium dependent protein kinase 0.0066 0.0563 0.0749
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0013 0.0012 0.0173
Plasmodium vivax CDK-related protein kinase 6, putative 0.0975 1 1
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0013 0.0012 0.0037
Echinococcus granulosus solute carrier family 22 0.0048 0.0373 0.049
Onchocerca volvulus 0.0048 0.0373 0.2058
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0048 0.0481
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0048 0.0373 0.0506
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0339 0.3395 0.4609
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0027 0.0157 0.0145
Echinococcus granulosus lysyl tRNA synthetase 0.0051 0.0411 0.0541
Schistosoma mansoni hypothetical protein 0.0177 0.1717 0.2331
Schistosoma mansoni hypothetical protein 0.0339 0.3395 0.4609
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0024 0.0072
Loa Loa (eye worm) major facilitator superfamily transporter 0.0048 0.0373 0.1098
Leishmania major glucose transporter, lmgt3 0.0105 0.0969 1
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0115 0.1073 0.1457
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0045 0.0345 0.1011
Onchocerca volvulus Glucosylceramidase homolog 0.0177 0.1717 1
Onchocerca volvulus 0.0048 0.0373 0.2058
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0028 0.0173 0.0503
Loa Loa (eye worm) hypothetical protein 0.0018 0.0063 0.0185
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0069 0.0594 0.0806
Schistosoma mansoni glucose transporter 0.0048 0.0373 0.0506
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0048 0.0373 0.0506
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.1174 0.3457
Echinococcus multilocularis synaptic vesicle 2 protein 0.0048 0.0373 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0373 0.1093
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0516 0.1521
Schistosoma mansoni glucose transport protein 0.0339 0.3395 0.4609
Brugia malayi Major Facilitator Superfamily protein 0.0048 0.0373 0.1098
Giardia lamblia Sugar-proton symporter 0.0048 0.0373 0.6198
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0609 0.0826
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.007 0.0609 0.0597
Toxoplasma gondii lysine-tRNA ligase 0.0051 0.0411 0.0603
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0061 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0271 0.2778
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0373 0.1093
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0271 0.0792
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0024 0.0066
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0049 0.005
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.007 0.0609 0.0903
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0048 0.0066
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0271 0.0792
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Toxoplasma gondii protein kinase, putative 0.0649 0.6616 1
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Brugia malayi Sugar transporter family protein 0.0339 0.3395 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.1098
Trypanosoma brucei glucosidase, putative 0.0038 0.0271 0.2778
Entamoeba histolytica hypothetical protein 0.0051 0.0411 0.6737
Trypanosoma brucei glucose transporter, putative 0.0105 0.0969 1
Trypanosoma brucei glucose transporter 1E 0.0105 0.0969 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0069 0.0594 0.1749
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0516 0.0701
Plasmodium vivax JmjC domain containing protein 0.0016 0.0048 0.0036
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0048 0.0373 0.1272
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.1098
Leishmania major hypothetical protein, conserved 0.0016 0.0048 0.0481
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0316 0.3155 0.9295
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.007 0.0609 0.0811
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0048 0.0036
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0048 0.0143
Trypanosoma brucei THT1 - hexose transporter, putative 0.0105 0.0969 1
Trichomonas vaginalis myo-inositol transporter, putative 0.0048 0.0373 0.1093
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0516 0.0701
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0048 0.0373 1
Brugia malayi valosin containing protein 0.0017 0.0051 0.015
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.008 0.0712 0.7347
Trypanosoma brucei glucose transporter, putative 0.0105 0.0969 1
Trypanosoma brucei glucose transporter, putative 0.0105 0.0969 1
Trichomonas vaginalis sugar transporter, putative 0.0105 0.0969 0.285
Plasmodium falciparum proline--tRNA ligase 0.008 0.0712 0.0701
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0027 0.0157 0.0214
Toxoplasma gondii sugar transporter ST1 0.0048 0.0373 0.0546
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0048 0.0481
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0024 0.0066
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Loa Loa (eye worm) hypothetical protein 0.0051 0.0411 0.1209
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0069 0.0594 0.0806
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0067
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0048 0.0066
Schistosoma mansoni tyrosine kinase 0.0077 0.0679 0.0922
Brugia malayi Furin-like cysteine rich region family protein 0.0145 0.1385 0.408
Schistosoma mansoni hypothetical protein 0.0036 0.0248 0.0337
Plasmodium falciparum calcium-dependent protein kinase 3 0.007 0.0609 0.0597
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0419 0.1235
Echinococcus multilocularis geminin 0.0177 0.1717 0.2331
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0051 0.0411 0.6849
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0048 0.0373 0.3835
Giardia lamblia Prolyl-tRNA synthetase 0.0069 0.0594 1
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1717 0.5054
Brugia malayi hypothetical protein 0.0048 0.0373 0.1098
Schistosoma mansoni hypothetical protein 0.0177 0.1717 0.2331
Loa Loa (eye worm) RecQ helicase 0.0022 0.011 0.0323
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0048 0.0049
Loa Loa (eye worm) hypothetical protein 0.007 0.0609 0.1793
Brugia malayi jmjC domain containing protein 0.0016 0.0048 0.0143
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0271 0.0792
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0044 0.033 0.8824
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Plasmodium vivax proline--tRNA ligase, putative 0.008 0.0712 0.0701
Schistosoma mansoni lysyl-tRNA synthetase 0.0051 0.0411 0.0557
Onchocerca volvulus 0.0048 0.0373 0.2058
Echinococcus multilocularis insulin receptor 0.0046 0.036 0.0488
Giardia lamblia Lysyl-tRNA synthetase 0.0051 0.0411 0.6849
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0051 0.0411 0.1406
Brugia malayi Major Facilitator Superfamily protein 0.0048 0.0373 0.1098
Plasmodium falciparum mitogen-activated protein kinase 2 0.0371 0.3732 0.3724
Echinococcus multilocularis microtubule associated protein 2 0.0721 0.7366 1
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1816 0.5346
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0048 0.0055
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1717 0.5054
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0049 0.0067
Loa Loa (eye worm) hypothetical protein 0.0016 0.0048 0.0143
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1816 0.5346
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.1098
Schistosoma mansoni tyrosine kinase 0.0046 0.036 0.0488
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0044 0.033 0.8824
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.268 0.7894
Schistosoma mansoni alpha-glucosidase 0.0147 0.14 0.19
Leishmania major hypothetical protein, conserved 0.0048 0.0373 0.3835
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0339 0.3395 0.4609
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0371 0.3732 0.3724
Leishmania major myo-inositol/proton symporter (MIT) 0.0048 0.0373 0.3835
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0024 0.0232
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0051 0.0411 0.1406
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.268 0.7894
Loa Loa (eye worm) sugar transporter 0.0048 0.0373 0.1098
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0013 0.0012 0.0031
Brugia malayi glycyl-tRNA synthetase 0.0013 0.0012 0.0037
Trypanosoma brucei sugar transporter, putative 0.0048 0.0373 0.3835
Brugia malayi Sugar transporter family protein 0.0048 0.0373 0.1098
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0048 0.0066
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0516 0.0701
Schistosoma mansoni protein kinase 0.007 0.0609 0.0826
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0048 0.0143
Trichomonas vaginalis glutaminase, putative 0.0286 0.2844 0.8378
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0271 0.4428
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.1098
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.011 0.0318
Onchocerca volvulus 0.0048 0.0373 0.2058
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0044 0.033 0.5469
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.1646 0.2235
Trichomonas vaginalis sugar transporter, putative 0.0105 0.0969 0.285
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0339 0.3395 0.4609
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0024 0.0066
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0028 0.0172 0.0506
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.1646 0.2222
Trypanosoma cruzi hexose transporter, putative 0.0105 0.0969 1
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0048 0.0066
Onchocerca volvulus 0.0048 0.0373 0.2058
Trypanosoma brucei Valosin-containing protein 0.0027 0.0157 0.1609
Echinococcus multilocularis bloom syndrome protein 0.0022 0.011 0.0149
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.007 0.0609 0.1793
Plasmodium vivax hexose transporter 0.0339 0.3395 0.3387
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0048 0.0066
Entamoeba histolytica protein kinase, putative 0.007 0.0609 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0024 0.0369
Treponema pallidum prolyl-tRNA synthetase 0.0024 0.0131 1
Echinococcus multilocularis glycyl tRNA synthetase 0.0013 0.0012 0.0017
Entamoeba histolytica protein kinase, putative 0.007 0.0609 1
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0051 0.0411 0.4226
Echinococcus multilocularis epidermal growth factor receptor 0.0145 0.1385 0.188
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0048 0.0373 1
Onchocerca volvulus Huntingtin homolog 0.0128 0.1208 0.6991
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.007 0.0609 0.0811
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Loa Loa (eye worm) vesicle-fusing ATPase 0.0017 0.0051 0.015
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.007 0.0609 0.0597
Trichomonas vaginalis sugar transport protein, putative 0.0048 0.0373 0.1093
Echinococcus multilocularis solute carrier family 22 0.0048 0.0373 0.0506
Schistosoma mansoni tyrosine kinase 0.0078 0.0688 0.0934
Echinococcus granulosus epidermal growth factor receptor 0.0145 0.1385 0.1867
Loa Loa (eye worm) hypothetical protein 0.0128 0.1208 0.3557
Schistosoma mansoni glucose transport protein 0.0339 0.3395 0.4609
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0048 0.0049
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0048 0.0066
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0371 0.3732 0.5632
Loa Loa (eye worm) hypothetical protein 0.0249 0.2461 0.7248
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0271 0.0367
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0013 0.0012 0.0037
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0271 0.0797
Trichomonas vaginalis glucose transporter, putative 0.0105 0.0969 0.285
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.1098
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.015
Onchocerca volvulus 0.0048 0.0373 0.2058
Echinococcus multilocularis calcium dependent protein kinase 0.0066 0.0563 0.0765
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.1098
Onchocerca volvulus 0.0098 0.0901 0.5178
Schistosoma mansoni tyrosine kinase 0.0078 0.0688 0.0934
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0028 0.0173 0.0218
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0248 0.0731
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0516 0.0701
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0048 0.0373 1
Mycobacterium ulcerans sugar transporter 0.0048 0.0373 0.1272
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0048 0.0066
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Loa Loa (eye worm) sugar transporter 0.0339 0.3395 1
Schistosoma mansoni sugar transporter 0.0048 0.0373 0.0506
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Toxoplasma gondii sugar transporter ST2 0.0048 0.0373 0.0546
Plasmodium falciparum hexose transporter 0.0339 0.3395 0.3387
Brugia malayi Major Facilitator Superfamily protein 0.0048 0.0373 0.1098
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.007 0.0609 0.0597
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1717 0.5054
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.008 0.0712 0.7347
Loa Loa (eye worm) TK/EGFR protein kinase 0.0145 0.1385 0.408
Brugia malayi Sugar transporter family protein 0.0048 0.0373 0.1098
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0271 0.0792
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0339 0.3395 0.46
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0082 0.0069
Trypanosoma brucei glucose transporter, putative 0.0105 0.0969 1
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0028 0.0173 0.0234
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0017 0.0054 0.0064
Trypanosoma brucei glucose transporter 2A 0.0105 0.0969 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0046 0.036 0.106
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Mycobacterium ulcerans glutaminase 0.0286 0.2844 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0046 0.036 0.0472
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0013 0.0012 0.0017
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0271 0.0391
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0048 0.0066
Plasmodium falciparum calcium-dependent protein kinase 4 0.007 0.0609 0.0597
Echinococcus multilocularis solute carrier family 22 0.0048 0.0373 0.0506
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0516 0.0685
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.008 0.0712 0.7347
Loa Loa (eye worm) hypothetical protein 0.0016 0.0049 0.0146
Trichomonas vaginalis sugar transporter, putative 0.0105 0.0969 0.285
Brugia malayi MH2 domain containing protein 0.0125 0.1174 0.3457
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.1646 0.4849
Brugia malayi glutaminase DH11.1 0.0286 0.2844 0.8379
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0049 0.005
Trypanosoma cruzi glucose transporter, putative 0.0048 0.0373 0.3835
Leishmania major glucose transporter, lmgt2 0.0105 0.0969 1
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0028 0.0173 0.0876
Trypanosoma cruzi hexose transporter, putative 0.0105 0.0969 1
Leishmania major glucose transporter, lmgt1 0.0105 0.0969 1
Leishmania major threonyl-tRNA synthetase, putative 0.0013 0.0012 0.0108
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Schistosoma mansoni glutaminase 0.0286 0.2844 0.3862
Trypanosoma cruzi hexose transporter, putative 0.0048 0.0373 0.3835
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0271 0.0792
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0048 0.0143
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0609 0.0826
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Toxoplasma gondii sugar transporter ST3 0.0048 0.0373 0.0546
Schistosoma mansoni tyrosine kinase 0.0077 0.0679 0.0922
Plasmodium vivax sugar transporter, putative 0.0048 0.0373 0.0361
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.008 0.0712 0.106
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.1646 0.4849
Schistosoma mansoni tyrosine kinase 0.0145 0.1385 0.188
Plasmodium vivax lysine--tRNA ligase, putative 0.0051 0.0411 0.0399
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Onchocerca volvulus 0.0048 0.0373 0.2058
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.268 0.7894
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0078 0.0688 0.0919
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0419 0.1235
Echinococcus multilocularis lysyl tRNA synthetase 0.0051 0.0411 0.0557
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0013 0.0012 0.0108
Echinococcus multilocularis solute carrier family 22 0.0048 0.0373 0.0506
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.1098
Chlamydia trachomatis proline--tRNA ligase 0.0024 0.0131 0.2978
Echinococcus granulosus GPCR family 2 0.0016 0.0049 0.005
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.027 0.268 0.7896
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0271 0.2778
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0339 0.3395 0.46
Trypanosoma cruzi hexose transporter, putative 0.0057 0.0474 0.4886
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1717 0.5054
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.008 0.0712 0.7347
Echinococcus granulosus solute carrier family 22 0.0048 0.0373 0.049
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1717 0.5054
Chlamydia trachomatis lysine--tRNA ligase 0.0051 0.0411 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0048 0.0055
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0024 0.0232
Loa Loa (eye worm) hypothetical protein 0.0069 0.0594 0.1749
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0069 0.0594 1
Brugia malayi major facilitator superfamily protein 0.0048 0.0373 0.1098
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.1098
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.007 0.0609 0.1793
Plasmodium falciparum calcium-dependent protein kinase 5 0.007 0.0609 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Trypanosoma brucei THT1 - hexose transporter, putative 0.0105 0.0969 1
Onchocerca volvulus 0.0048 0.0373 0.2058
Schistosoma mansoni protein kinase 0.007 0.0609 0.0826
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0024 0.0066
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.1098
Brugia malayi jmjC domain containing protein 0.0061 0.0516 0.1521
Schistosoma mansoni glycyl-tRNA synthetase 0.0013 0.0012 0.0017
Onchocerca volvulus 0.0048 0.0373 0.2058
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.1717 0.5054
Onchocerca volvulus 0.0048 0.0373 0.2058
Brugia malayi jmjC domain containing protein 0.0061 0.0516 0.1521
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0049 0.0146
Echinococcus granulosus geminin 0.0177 0.1717 0.2318
Echinococcus multilocularis solute carrier family 22 0.0048 0.0373 0.0506
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0024 0.0066
Brugia malayi vesicle-fusing ATPase 0.0017 0.0051 0.015
Loa Loa (eye worm) hypothetical protein 0.0048 0.0373 0.1098
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Trypanosoma cruzi sugar transporter, putative 0.0048 0.0373 0.3835
Schistosoma mansoni sugar transporter 0.0048 0.0373 0.0506
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0609 0.1788
Schistosoma mansoni sugar transporter 0.0048 0.0373 0.0506
Brugia malayi jmjC domain containing protein 0.0016 0.0048 0.0143
Echinococcus granulosus synaptic vesicle 2 protein 0.0048 0.0373 0.049
Onchocerca volvulus 0.0048 0.0373 0.2058
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0969 0.285
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.011 0.0323
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0271 0.0792
Leishmania major protein kinase, putative 0.007 0.0609 0.6273
Echinococcus granulosus epidermal growth factor receptor 0.0078 0.0688 0.0919
Echinococcus granulosus phd:f box containing protein 0.0016 0.0048 0.0049
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0516 0.0701
Trypanosoma cruzi hexose transporter, putative 0.0105 0.0969 1
Toxoplasma gondii cell division protein CDC48AP 0.0017 0.0054 0.0064
Echinococcus granulosus solute carrier family 22 0.0048 0.0373 0.049
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0048 0.0049
Trypanosoma cruzi hexose transporter 0.0105 0.0969 1
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0027 0.0157 0.0145
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0609 0.0826
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.008 0.0712 0.7347
Mycobacterium ulcerans ATPase 0.0017 0.0054 0.0148
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0013 0.0012 0.0108
Onchocerca volvulus 0.0048 0.0373 0.2058
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0069 0.0594 0.1749
Schistosoma mansoni glucose transport protein 0.0339 0.3395 0.4609
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.0969 0.285
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0024 0.0232
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.1174 0.3457
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.011 0.0318
Schistosoma mansoni sugar transporter 0.0048 0.0373 0.0506
Trichomonas vaginalis glucose transporter, putative 0.0105 0.0969 0.285
Echinococcus granulosus Sugar transporter ERD6 protein 0.0048 0.0373 0.049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0419 0.1235
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0049 0.0067
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0049 0.0146
Brugia malayi Cam kinase protein 1 0.007 0.0609 0.1793
Plasmodium falciparum calcium-dependent protein kinase 1 0.007 0.0609 0.0597
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0013 0.0012 0.0173
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0051 0.0411 0.1204
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Trypanosoma cruzi Valosin-containing protein, putative 0.0027 0.0157 0.1609
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0051 0.0411 0.4226
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0048 0.0481
Trypanosoma brucei glucose transporter, putative 0.0105 0.0969 1
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0013 0.0012 0.0108
Schistosoma mansoni hypothetical protein 0.0016 0.0049 0.0067
Trichomonas vaginalis sugar transporter, putative 0.0048 0.0373 0.1093
Mycobacterium ulcerans integral membrane transport protein 0.0048 0.0373 0.1272
Giardia lamblia AAA family ATPase 0.0017 0.0054 0.0723
Schistosoma mansoni alpha-glucosidase 0.0147 0.14 0.19
Brugia malayi hypothetical protein 0.0048 0.0373 0.1098
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0048 0.0373 0.0361
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.007 0.0609 0.0811
Onchocerca volvulus 0.0048 0.0373 0.2058
Loa Loa (eye worm) hypothetical protein 0.0069 0.0594 0.1749
Trichomonas vaginalis glucosylceramidase, putative 0.027 0.268 0.7894

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 0 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 10.7 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 13.98 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 14.64 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 65 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 97 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 0 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -10 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = -3 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 65 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 97 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.09 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.82039 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.