Detailed information for compound 595828

Basic information

Technical information
  • TDR Targets ID: 595828
  • Name: 4-[(1,3-diaminopyrrolo[3,2-f]quinazolin-7-yl) methyl]benzonitrile
  • MW: 314.344 | Formula: C18H14N6
  • H donors: 2 H acceptors: 3 LogP: 2.24 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)Cn1ccc2c1ccc1c2c(N)nc(n1)N
  • InChi: 1S/C18H14N6/c19-9-11-1-3-12(4-2-11)10-24-8-7-13-15(24)6-5-14-16(13)17(20)23-18(21)22-14/h1-8H,10H2,(H4,20,21,22,23)
  • InChiKey: IZYHVTAYLHFZSP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(1,3-diamino-7-pyrrolo[3,2-f]quinazolinyl)methyl]benzonitrile
  • DAQ4A
  • AIDS-212667
  • AIDS212667
  • Benzonitrile, 4-[(1,3-diamino-7H-pyrrolo[3,2-f]quinazolin-7-yl)methyl]-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania mexicana glucose transporter, lmgt2 Starlite/ChEMBL No references
Lactobacillus casei Dihydrofolate reductase Starlite/ChEMBL References
Homo sapiens solute carrier family 2 (facilitated glucose transporter), member 1 Starlite/ChEMBL No references
Rattus norvegicus Dihydrofolate reductase Starlite/ChEMBL References
Mus musculus dihydrofolate reductase Starlite/ChEMBL References
Plasmodium falciparum hexose transporter Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Loa Loa (eye worm) sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania braziliensis lmgt2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum ko:K07191 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania major glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Brugia malayi Dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania donovani glucose transporter 3, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania mexicana glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania braziliensis glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 1, putative Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium ulcerans dihydrofolate reductase DfrA Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania major glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Chlamydia trachomatis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Brugia malayi Sugar transporter family protein Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Neospora caninum Glucose transporter 1A, related Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma cruzi hexose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans hypothetical protein Get druggable targets OG5_128410 All targets in OG5_128410
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127135 All targets in OG5_127135
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum ko:K07299 MFS transporter, SP family, solute carrier family 2 (facilitated, putative Get druggable targets OG5_127135 All targets in OG5_127135
Brugia malayi dihydrofolate reductase family protein Get druggable targets OG5_128410 All targets in OG5_128410
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 3, putative Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania mexicana glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus granulosus solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis sugar transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus granulosus General substrate transporter Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma japonicum ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative Get druggable targets OG5_128410 All targets in OG5_128410
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium yoelii putative sugar transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum Solute carrier family 2, facilitated glucose transporter member 4, putative Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania braziliensis glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Loa Loa (eye worm) dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei THT1 - hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium falciparum hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei gambiense glucose transporter,glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B Get druggable targets OG5_129633 All targets in OG5_129633
Plasmodium knowlesi hexose transporter, putative Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania mexicana glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans almost identical to C terminus of CaP19.2425 Get druggable targets OG5_127135 All targets in OG5_127135
Echinococcus multilocularis dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania donovani glucose transporter 1 Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma congolense glucose transporter 2A, putative Get druggable targets OG5_129633 All targets in OG5_129633
Candida albicans C terminus is almost identical to CaP19.2865 Get druggable targets OG5_127135 All targets in OG5_127135
Leishmania donovani glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) Get druggable targets OG5_128410 All targets in OG5_128410
Echinococcus multilocularis solute carrier family 2, facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania mexicana glucose transporter, lmgt2 Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma cruzi hexose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania major glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Toxoplasma gondii facilitative glucose transporter GT1 Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni glucose transport protein Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium vivax hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Plasmodium berghei hexose transporter Get druggable targets OG5_127135 All targets in OG5_127135
Schistosoma mansoni dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Leishmania infantum glucose transporter, lmgt1 Get druggable targets OG5_129633 All targets in OG5_129633
Schistosoma japonicum IPR005828,General substrate transporter,domain-containing Get druggable targets OG5_127135 All targets in OG5_127135
Trypanosoma brucei glucose transporter 1E Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum glucose transporter/membrane transporter D2, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Leishmania infantum glucose transporter, lmgt3 Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma congolense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense hexose transporter,glucose transporter 1B, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense glucose transporter Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei gambiense glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Trypanosoma brucei glucose transporter, putative Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus granulosus dihydrofolate reductase Get druggable targets OG5_128410 All targets in OG5_128410
Trypanosoma brucei glucose transporter 2A Get druggable targets OG5_129633 All targets in OG5_129633
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_129633 All targets in OG5_129633
Echinococcus multilocularis solute carrier family 2 facilitated glucose Get druggable targets OG5_127135 All targets in OG5_127135
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania infantum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Plasmodium knowlesi bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 209 aa 29.2 %
Leishmania mexicana dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 33.7 %
Cryptosporidium hominis chain A, crystal structure of Dhfr Dihydrofolate reductase   187 aa 182 aa 34.1 %
Leishmania major dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Neospora caninum Bifunctional dihydrofolate reductase-thymidylate synthase, related Dihydrofolate reductase   187 aa 187 aa 35.8 %
Theileria parva dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 193 aa 32.1 %
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 202 aa 29.2 %
Plasmodium berghei bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 211 aa 28.4 %
Cryptosporidium parvum dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 182 aa 33.5 %
Trypanosoma brucei glucose transporter, putative solute carrier family 2 (facilitated glucose transporter), member 1 492 aa 395 aa 23.5 %
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative Dihydrofolate reductase   187 aa 209 aa 29.2 %
Trypanosoma brucei glucose transporter, putative hexose transporter 504 aa 426 aa 22.3 %
Leishmania braziliensis dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 34.3 %
Onchocerca volvulus Putative dihydrofolate reductase Dihydrofolate reductase   163 aa 173 aa 27.2 %
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 186 aa 37.1 %
Plasmodium yoelii thymidylate synthase, putative Dihydrofolate reductase   187 aa 212 aa 27.8 %
Leishmania donovani dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 172 aa 36.0 %
Babesia bovis dihydrofolate reductase/thymidilate synthase Dihydrofolate reductase   187 aa 191 aa 31.9 %
Trypanosoma brucei gambiense dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 210 aa 30.0 %
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase dihydrofolate reductase 187 aa 207 aa 30.4 %
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase Dihydrofolate reductase   187 aa 210 aa 30.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major glucose transporter, lmgt3 0.0039 0.0581 0.1533
Leishmania major threonyl-tRNA synthetase, putative 0.0006 0.0052 0.0138
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0006 0.0052 0.1834
Loa Loa (eye worm) dihydrofolate reductase 0.0623 1 1
Trichomonas vaginalis myo-inositol transporter, putative 0.0018 0.0236 0.0605
Echinococcus multilocularis histidyl tRNA synthetase 0.0004 0.0011 0.0011
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0429 0.0429
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Schistosoma mansoni glucose transport protein 0.0126 0.1987 0.1987
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Plasmodium falciparum threonine--tRNA ligase 0.0006 0.0052 0.0068
Trypanosoma brucei glucose transporter, putative 0.0039 0.0581 0.1533
Toxoplasma gondii sugar transporter ST1 0.0018 0.0236 0.0463
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0357 0.0346
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0004 0.0011 0.0011
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0006 0.0041 0.0107
Leishmania major myo-inositol/proton symporter (MIT) 0.0018 0.0236 0.0623
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0004 0.0011 0.0011
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0018 0.0236 0.0225
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0236 0.0236
Trichomonas vaginalis glucose transporter, putative 0.0018 0.0236 0.0605
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0238 0.3793 1
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0006 0.0052 0.0103
Echinococcus granulosus glycyl tRNA synthetase 0.0006 0.0052 0.0052
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0006 0.0052 0.1031
Loa Loa (eye worm) hypothetical protein 0.0028 0.0395 0.0395
Plasmodium vivax asparagine--tRNA ligase, putative 0.0004 0.0011 0.0015
Schistosoma mansoni aspartyl-tRNA synthetase 0.0004 0.0011 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0034 0.0497 0.0497
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0375 0.0375
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0034 0.0497 0.9778
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0307 0.0787
Plasmodium falciparum protein kinase 6 0.048 0.7696 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0183 0.2899 0.3767
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0375 0.0375
Echinococcus granulosus lamin dm0 0.0026 0.0375 0.0375
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0155 0.0155
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0236 0.0236
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0295 0.0778
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0035 0.0509 0.0661
Trypanosoma brucei glucose transporter 2A 0.0039 0.0581 0.1533
Chlamydia trachomatis dihydrofolate reductase 0.0623 1 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1987 0.1987
Schistosoma mansoni glucose transport protein 0.0126 0.1987 0.1987
Plasmodium vivax SET domain protein, putative 0.0031 0.0448 0.0582
Plasmodium vivax sugar transporter, putative 0.0018 0.0236 0.0307
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0581 0.149
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0126 0.1987 0.1987
Leishmania major hypothetical protein, conserved 0.0006 0.0041 0.0107
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0034 0.0497 0.1275
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0034 0.0497 0.0497
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0004 0.0011 0.0022
Giardia lamblia Threonyl-tRNA synthetase 0.0006 0.0052 0.1055
Brugia malayi hypothetical protein 0.0018 0.0236 0.0236
Toxoplasma gondii facilitative glucose transporter GT1 0.0126 0.1987 0.3891
Onchocerca volvulus 0.0018 0.0236 0.0605
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0004 0.0011 0.0029
Plasmodium vivax calcium-dependent protein kinase, putative 0.0035 0.0509 0.0661
Schistosoma mansoni glycyl-tRNA synthetase 0.0006 0.0052 0.0052
Onchocerca volvulus 0.0026 0.0375 0.0962
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0004 0.0011 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Loa Loa (eye worm) hypothetical protein 0.0025 0.0357 0.0357
Plasmodium vivax glycine--tRNA ligase, putative 0.0006 0.0052 0.0068
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0588 0.1551
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0035 0.0509 0.0509
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1987 0.1987
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0623 1 1
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0006 0.0052 0.0138
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0025 0.0357 0.0915
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0581 0.1533
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0004 0.0011 0.0225
Onchocerca volvulus 0.0018 0.0236 0.0605
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0448 0.0448
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0581 0.1533
Mycobacterium ulcerans integral membrane transport protein 0.0018 0.0236 0.0225
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0236 0.0623
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0006 0.0052 0.0138
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Trypanosoma cruzi glucose transporter, putative 0.0018 0.0236 0.0623
Onchocerca volvulus 0.0026 0.0375 0.0962
Mycobacterium ulcerans hypothetical protein 0.0006 0.0041 0.0029
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0238 0.3793 0.4928
Echinococcus granulosus Sugar transporter ERD6 protein 0.0018 0.0236 0.0236
Treponema pallidum threonyl-tRNA synthetase 0.0006 0.0052 0.3127
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Brugia malayi Dihydrofolate reductase 0.0623 1 1
Giardia lamblia Glycyl-tRNA synthetase 0.0006 0.0052 0.1055
Loa Loa (eye worm) hypothetical protein 0.0031 0.0448 0.0448
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0006 0.0041 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0041 0.0104
Onchocerca volvulus 0.0018 0.0236 0.0605
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0006 0.0041 0.0079
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0004 0.0011 0.022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0236 0.0236
Schistosoma mansoni aspartyl-tRNA synthetase 0.0004 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0236 0.0605
Brugia malayi intermediate filament protein 0.0026 0.0375 0.0375
Echinococcus granulosus lamin 0.0026 0.0375 0.0375
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0178 0.0178
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0238 0.3793 0.7427
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0025 0.0357 0.0357
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0014 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0018 0.0236 0.0236
Leishmania major glucose transporter/membrane transporter D2, putative 0.0039 0.0581 0.1533
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0018 0.0236 0.0307
Brugia malayi Sugar transporter family protein 0.0018 0.0236 0.0236
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0357 0.0357
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0581 0.149
Loa Loa (eye worm) hypothetical protein 0.0018 0.0236 0.0236
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0004 0.0011 0.0011
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0581 0.1533
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0006 0.0052 0.0052
Echinococcus granulosus solute carrier family 22 0.0018 0.0236 0.0236
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0035 0.0509 0.0661
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.3422 0.3422
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0581 0.1533
Plasmodium falciparum glycine--tRNA ligase 0.0004 0.0011 0.0015
Echinococcus multilocularis synaptic vesicle 2 protein 0.0018 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0018 0.0236 0.0236
Plasmodium falciparum protein kinase 7 0.0319 0.5106 0.6635
Loa Loa (eye worm) 63kd antigen 0.0004 0.0011 0.0011
Onchocerca volvulus 0.0018 0.0236 0.0605
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0018 0.0236 1
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0623 1 1
Leishmania major lysyl-tRNA synthetase, putative 0.0025 0.0357 0.0942
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Loa Loa (eye worm) hypothetical protein 0.0018 0.0236 0.0236
Plasmodium vivax hexose transporter 0.0126 0.1987 0.2582
Giardia lamblia Asparaginyl-tRNA synthetase 0.0004 0.0011 0.0225
Leishmania major lysyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0034 0.0497 0.0497
Plasmodium falciparum calcium-dependent protein kinase 2 0.0035 0.0509 0.0661
Plasmodium vivax CDK-related protein kinase 6, putative 0.048 0.7696 1
Toxoplasma gondii glycyl-tRNA synthetase 0.0006 0.0052 0.0103
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0006 0.0052 0.1834
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Onchocerca volvulus 0.0018 0.0236 0.0605
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Mycobacterium leprae conserved hypothetical protein 0.0006 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0236 0.0236
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0006 0.0052 0.0041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0236 0.0236
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0035 0.0509 0.1341
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Loa Loa (eye worm) hypothetical protein 0.0013 0.0155 0.0155
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0006 0.0052 0.0052
Echinococcus granulosus Threonyl tRNA synthetase C 0.0006 0.0052 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0448 0.0448
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0004 0.0011 0.0011
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.004 0.0588 0.1551
Giardia lamblia Sugar-proton symporter 0.0018 0.0236 0.4749
Chlamydia trachomatis lysine--tRNA ligase 0.0025 0.0357 0.0346
Echinococcus multilocularis General substrate transporter 0.0108 0.17 0.17
Schistosoma mansoni sugar transporter 0.0018 0.0236 0.0236
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0375 0.0375
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0581 0.149
Onchocerca volvulus 0.0018 0.0236 0.0605
Leishmania major histidyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Trypanosoma brucei glucose transporter, putative 0.0039 0.0581 0.1533
Schistosoma mansoni aspartyl-tRNA synthetase 0.0004 0.0011 0.0011
Treponema pallidum glycyl-tRNA synthetase 0.0004 0.0011 0.002
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0034 0.0497 0.0497
Echinococcus multilocularis solute carrier family 22 0.0018 0.0236 0.0236
Brugia malayi lysyl-tRNA synthetase 0.0025 0.0357 0.0357
Trypanosoma brucei sugar transporter, putative 0.0018 0.0236 0.0623
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0004 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0236 0.0605
Plasmodium falciparum aspartate--tRNA ligase 0.0004 0.0011 0.0015
Plasmodium falciparum calcium-dependent protein kinase 4 0.0035 0.0509 0.0661
Entamoeba histolytica protein kinase, putative 0.0035 0.0509 1
Brugia malayi Cam kinase protein 1 0.0035 0.0509 0.0509
Schistosoma mansoni protein kinase 0.0035 0.0509 0.0509
Plasmodium falciparum calcium-dependent protein kinase 5 0.0035 0.0509 0.0661
Echinococcus granulosus histidyl tRNA synthetase 0.0004 0.0011 0.0011
Echinococcus granulosus solute carrier family 22 0.0018 0.0236 0.0236
Echinococcus multilocularis lysyl tRNA synthetase 0.0025 0.0357 0.0357
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Loa Loa (eye worm) hypothetical protein 0.0035 0.0509 0.0509
Schistosoma mansoni histidyl-tRNA synthetase 0.0004 0.0011 0.0011
Plasmodium vivax aspartate--tRNA ligase, putative 0.0004 0.0011 0.0015
Onchocerca volvulus 0.0031 0.0448 0.1148
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0183 0.2899 0.3767
Schistosoma mansoni threonyl-tRNA synthetase 0.0004 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0236 0.0236
Echinococcus granulosus solute carrier family 22 0.0018 0.0236 0.0236
Entamoeba histolytica hypothetical protein 0.0025 0.0357 0.7022
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0581 0.1533
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0296 0.0296
Mycobacterium ulcerans sugar transporter 0.0018 0.0236 0.0225
Schistosoma mansoni serine/threonine protein kinase 0.0035 0.0509 0.0509
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0006 0.0052 0.0134
Brugia malayi hypothetical protein 0.0018 0.0236 0.0236
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0183 0.2899 0.5677
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Brugia malayi Aspartyl-tRNA synthetase 0.0004 0.0011 0.0011
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0012 0.0143 0.0132
Onchocerca volvulus 0.0245 0.3901 1
Leishmania major glucose transporter, lmgt1 0.0039 0.0581 0.1533
Trypanosoma brucei glucose transporter, putative 0.0039 0.0581 0.1533
Loa Loa (eye worm) hypothetical protein 0.0034 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0018 0.0236 0.0236
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Loa Loa (eye worm) hypothetical protein 0.0026 0.0375 0.0375
Schistosoma mansoni aspartyl-tRNA synthetase 0.0004 0.0011 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Schistosoma mansoni lamin 0.0026 0.0375 0.0375
Schistosoma mansoni sugar transporter 0.0018 0.0236 0.0236
Trypanosoma brucei glucose transporter, putative 0.0039 0.0581 0.1533
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0018 0.0236 0.0236
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0581 0.149
Echinococcus granulosus calcium dependent protein kinase 0.0032 0.0474 0.0474
Plasmodium falciparum asparagine--tRNA ligase 0.0004 0.0011 0.0015
Brugia malayi Pre-SET motif family protein 0.0031 0.0448 0.0448
Toxoplasma gondii aspartate-tRNA ligase 0.0004 0.0011 0.0022
Trichomonas vaginalis set domain proteins, putative 0.0245 0.3901 1
Schistosoma mansoni intermediate filament proteins 0.0026 0.0375 0.0375
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Trichomonas vaginalis sugar transport protein, putative 0.0018 0.0236 0.0605
Plasmodium falciparum histidine--tRNA ligase, putative 0.0004 0.0011 0.0015
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0509 0.0509
Leishmania major aspartyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Trichomonas vaginalis sugar transporter, putative 0.0039 0.0581 0.149
Toxoplasma gondii protein kinase, putative 0.0319 0.5106 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0035 0.0509 0.0509
Trypanosoma brucei glucose transporter, putative 0.0039 0.0581 0.1533
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0006 0.0041 0.0107
Loa Loa (eye worm) hypothetical protein 0.0018 0.0236 0.0236
Giardia lamblia Aspartyl-tRNA synthetase 0.0004 0.0011 0.0225
Onchocerca volvulus 0.0018 0.0236 0.0605
Loa Loa (eye worm) hypothetical protein 0.0018 0.0236 0.0236
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1987 0.1987
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0006 0.0052 0.1031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0448 0.0448
Schistosoma mansoni histidyl-tRNA synthetase 0.0004 0.0011 0.0011
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0296 0.0296
Loa Loa (eye worm) sugar transporter 0.0018 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0012 0.0147 0.0147
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0126 0.1987 0.1987
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Echinococcus multilocularis solute carrier family 22 0.0018 0.0236 0.0236
Schistosoma mansoni sugar transporter 0.0018 0.0236 0.0236
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0623 1 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0238 0.3793 0.4928
Plasmodium falciparum hexose transporter 0.0126 0.1987 0.2582
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0581 0.149
Brugia malayi hypothetical protein 0.0018 0.0236 0.0236
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0041 0.0107
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0052 0.0138
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Echinococcus multilocularis glycyl tRNA synthetase 0.0006 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0126 0.1987 0.1987
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.004 0.0588 0.1152
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0004 0.0011 0.0011
Echinococcus granulosus General substrate transporter 0.0108 0.17 0.17
Echinococcus granulosus dihydrofolate reductase 0.0623 1 1
Schistosoma mansoni dihydrofolate reductase 0.0623 1 1
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Leishmania major hypothetical protein, conserved 0.0006 0.0041 0.0107
Onchocerca volvulus 0.0018 0.0236 0.0605
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0035 0.0509 0.0661
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0035 0.0509 0.0997
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0004 0.0011 0.022
Plasmodium falciparum calcium-dependent protein kinase 1 0.0035 0.0509 0.0661
Brugia malayi Major Facilitator Superfamily protein 0.0018 0.0236 0.0236
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0004 0.0011 0.0011
Schistosoma mansoni glucose transport protein 0.0126 0.1987 0.1987
Trypanosoma brucei glucose transporter 1E 0.0039 0.0581 0.1533
Trypanosoma cruzi hexose transporter 0.0039 0.0581 0.1533
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0035 0.0509 0.0997
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0509 0.0509
Plasmodium vivax lysine--tRNA ligase, putative 0.0025 0.0357 0.0464
Echinococcus multilocularis solute carrier family 22 0.0018 0.0236 0.0236
Chlamydia trachomatis threonine--tRNA ligase 0.0006 0.0052 0.0041
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0448 0.0448
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Loa Loa (eye worm) sugar transporter 0.0126 0.1987 0.1987
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0006 0.0052 0.0041
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0018 0.0236 0.0236
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0041 0.0107
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0035 0.0509 0.0509
Schistosoma mansoni aspartyl-tRNA synthetase 0.0004 0.0011 0.0011
Leishmania major glycyl tRNA synthetase, putative 0.0004 0.0011 0.003
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0035 0.0509 0.0509
Trypanosoma brucei histidyl-tRNA synthetase 0.0004 0.0011 0.003
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0226 0.3604 0.3604
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0041 0.0104
Trypanosoma brucei glucose transporter, putative 0.0039 0.0581 0.1533
Loa Loa (eye worm) hypothetical protein 0.0012 0.0147 0.0147
Schistosoma mansoni protein kinase 0.0035 0.0509 0.0509
Plasmodium falciparum proline--tRNA ligase 0.004 0.0588 0.0764
Echinococcus multilocularis lamin dm0 0.0026 0.0375 0.0375
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0178 0.0178
Giardia lamblia Hexose transporter 0.0018 0.0236 0.4749
Brugia malayi follicle stimulating hormone receptor 0.0226 0.3604 0.3604
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0236 0.0605
Toxoplasma gondii transporter, major facilitator family protein 0.0018 0.0236 0.0463
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0238 0.3793 1
Chlamydia trachomatis proline--tRNA ligase 0.0012 0.0143 0.0132
Toxoplasma gondii anticodon binding domain-containing protein 0.0004 0.0011 0.0022
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0236 0.0236
Giardia lamblia Lysyl-tRNA synthetase 0.0025 0.0357 0.7182
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0006 0.0052 0.0052
Mycobacterium tuberculosis Conserved hypothetical protein 0.0006 0.0041 0.0041
Brugia malayi major facilitator superfamily protein 0.0018 0.0236 0.0236
Leishmania major aspartyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Giardia lamblia Prolyl-tRNA synthetase 0.0034 0.0497 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0509 0.0509
Brugia malayi major facilitator superfamily protein 0.0018 0.0236 0.0236
Onchocerca volvulus 0.0018 0.0236 0.0605
Toxoplasma gondii lysine-tRNA ligase 0.0025 0.0357 0.0699
Schistosoma mansoni aspartyl-tRNA synthetase 0.0004 0.0011 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0006 0.0052 0.0052
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0035 0.0509 0.0997
Brugia malayi glycyl-tRNA synthetase 0.0006 0.0052 0.0052
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1987 0.1987
Echinococcus multilocularis dihydrofolate reductase 0.0623 1 1
Schistosoma mansoni glucose transporter 0.0018 0.0236 0.0236
Onchocerca volvulus 0.0018 0.0236 0.0605
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0018 0.0236 0.0236
Plasmodium vivax asparagine--tRNA ligase, putative 0.0004 0.0011 0.0015
Trypanosoma cruzi sugar transporter, putative 0.0018 0.0236 0.0623
Loa Loa (eye worm) hypothetical protein 0.0018 0.0236 0.0236
Echinococcus granulosus lysyl tRNA synthetase 0.0025 0.0357 0.0357
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0588 0.1551
Loa Loa (eye worm) hypothetical protein 0.0018 0.0236 0.0236
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0588 0.1551
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Echinococcus granulosus synaptic vesicle 2 protein 0.0018 0.0236 0.0236
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0025 0.0357 0.0346
Echinococcus multilocularis calcium dependent protein kinase 0.0032 0.0474 0.0474
Onchocerca volvulus 0.0018 0.0236 0.0605
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Trypanosoma brucei THT1 - hexose transporter, putative 0.0039 0.0581 0.1533
Echinococcus multilocularis lamin 0.0026 0.0375 0.0375
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0448 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0236 0.0605
Plasmodium falciparum lysine--tRNA ligase 0.0025 0.0357 0.0464
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0006 0.0052 0.0052
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0025 0.0357 0.0942
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Plasmodium vivax proline--tRNA ligase, putative 0.004 0.0588 0.0764
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0509 0.0509
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.004 0.0588 0.1551
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0296 0.0296
Brugia malayi Pre-SET motif family protein 0.0215 0.3422 0.3422
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0041 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.1987 0.5092
Trypanosoma cruzi histidyl-tRNA synthetase 0.0004 0.0011 0.003
Plasmodium falciparum asparagine--tRNA ligase 0.0004 0.0011 0.0015
Echinococcus multilocularis solute carrier family 22 0.0018 0.0236 0.0236
Leishmania major hypothetical protein, conserved 0.0018 0.0236 0.0623
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1987 0.1987
Loa Loa (eye worm) hypothetical protein 0.0034 0.0497 0.0497
Onchocerca volvulus 0.0018 0.0236 0.0605
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0006 0.0052 0.0052
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0018 0.0236 0.0225
Trypanosoma brucei glucose transporter, putative 0.0039 0.0581 0.1533
Trichomonas vaginalis glucose transporter, putative 0.0039 0.0581 0.149
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0509 0.0509
Brugia malayi Sugar transporter family protein 0.0018 0.0236 0.0236
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0497 0.0497
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0006 0.0052 0.0052
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0034 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0006 0.0052 0.0052
Echinococcus granulosus solute carrier family 22 0.0018 0.0236 0.0236
Brugia malayi Sugar transporter family protein 0.0126 0.1987 0.1987
Loa Loa (eye worm) hypothetical protein 0.0018 0.0236 0.0236
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0126 0.1987 0.1987
Schistosoma mansoni lysyl-tRNA synthetase 0.0025 0.0357 0.0357
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Loa Loa (eye worm) hypothetical protein 0.0026 0.0367 0.0367
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0155 0.0155
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0006 0.0052 0.0138
Trypanosoma brucei glucose transporter, putative 0.0039 0.0581 0.1533
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0004 0.0011 0.0012
Onchocerca volvulus 0.0018 0.0236 0.0605
Onchocerca volvulus Putative transporter 0.0018 0.0236 0.0605
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Schistosoma mansoni aspartyl-tRNA synthetase 0.0004 0.0011 0.0011
Schistosoma mansoni protein kinase 0.0035 0.0509 0.0509
Onchocerca volvulus 0.0018 0.0236 0.0605
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0004 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0236 0.0605
Onchocerca volvulus 0.0018 0.0236 0.0605
Onchocerca volvulus 0.0018 0.0236 0.0605
Echinococcus multilocularis musashi 0.0026 0.0375 0.0375
Echinococcus granulosus intermediate filament protein 0.0026 0.0375 0.0375
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Plasmodium vivax histidine--tRNA ligase, putative 0.0004 0.0011 0.0015
Plasmodium falciparum calcium-dependent protein kinase 3 0.0035 0.0509 0.0661
Toxoplasma gondii sugar transporter ST2 0.0018 0.0236 0.0463
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0018 0.0236 0.0236
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0035 0.0509 0.0509
Leishmania major glucose transporter, lmgt2 0.0039 0.0581 0.1533
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0238 0.3793 1
Schistosoma mansoni lamin 0.0026 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0018 0.0236 0.0236
Schistosoma mansoni aspartyl-tRNA synthetase 0.0004 0.0011 0.0011
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0035 0.0509 0.0509
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0448 0.0448
Leishmania major asparaginyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Entamoeba histolytica protein kinase, putative 0.0035 0.0509 1
Schistosoma mansoni sugar transporter 0.0018 0.0236 0.0236
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0004 0.0011 0.0029
Leishmania major protein kinase, putative 0.0035 0.0509 0.1341
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0025 0.0357 0.0942
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0448 0.0877
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0034 0.0497 0.0497
Plasmodium vivax threonine--tRNA ligase, putative 0.0006 0.0052 0.0068
Treponema pallidum prolyl-tRNA synthetase 0.0012 0.0143 1
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0004 0.0011 0.0011
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0004 0.0011 0.0029
Loa Loa (eye worm) major facilitator superfamily transporter 0.0018 0.0236 0.0236
Trichomonas vaginalis CAMK family protein kinase 0.0035 0.0509 0.1304
Trichomonas vaginalis sugar transporter, putative 0.0018 0.0236 0.0605
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0018 0.0236 0.0623
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0004 0.0011 0.003
Toxoplasma gondii sugar transporter ST3 0.0018 0.0236 0.0463
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0448 0.0448

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.1 nM Inhibition of rat DHFR extracted from liver using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition by spectrofluorometric analysis ChEMBL. 25937878
IC50 (binding) = 4 nM Inhibition of DHFR in mouse L1210 cells using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition by spectrofluorometric analysis ChEMBL. 25937878
IC50 (binding) = 6.4 nM Inhibition of DHFR in Lactobacillus casei using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition by spectrofluorometric analysis ChEMBL. 25937878
IC50 (functional) = 40 nM Cytotoxicity against mouse L1210 cells assessed as growth inhibition after 48 hrs by MTT assay ChEMBL. 25937878
IC50 (functional) = 537 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) = 699 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
IC50 (functional) = 777 nM ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 64 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 77.74 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 82.61 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 84.19 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 92 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 95 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 5 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = 0 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 64 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 92 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 95 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 8.48 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.00329 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 25937878

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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