TDR Targets

Basic information

Technical information

TDR Targets ID: 611656
Name: N-(4-fluorophenyl)-3-[[2-(phenoxy)acetyl]amin o]-1-benzofuran-2-carboxamide
MW: 404.39 | Formula: C23H17FN2O4
H donors: 2 H acceptors: 2 LogP: 5.02 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1c(oc2c1cccc2)C(=O)Nc1ccc(cc1)F)COc1ccccc1
InChi: 1S/C23H17FN2O4/c24-15-10-12-16(13-11-15)25-23(28)22-21(18-8-4-5-9-19(18)30-22)26-20(27)14-29-17-6-2-1-3-7-17/h1-13H,14H2,(H,25,28)(H,26,27)
InChiKey: QBJWCNKTTYNADS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-fluorophenyl)-3-[[2-(phenoxy)acetyl]amino]benzofuran-2-carboxamide
N-(4-fluorophenyl)-3-[[1-oxo-2-(phenoxy)ethyl]amino]-2-benzofurancarboxamide
N-(4-fluorophenyl)-3-[2-(phenoxy)ethanoylamino]-1-benzofuran-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0002	0.5
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0102	0.1604
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0279	0.0306
Trypanosoma cruzi	FAD dependent oxidoreductase, putative	0.0053	0.0557	1
Loa Loa (eye worm)	bromodomain containing protein	0.0039	0.0324	0.0324
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0279	0.0279
Entamoeba histolytica	NAD(FAD)-dependent dehydrogenase, putative	0.0057	0.0627	1
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase, putative	0.0053	0.0557	1
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0279	0.4999
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0279	0.0279
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0415	0.0821
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0415	0.1754
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1209	0.1209
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0279	0.5015
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0102	0.0112
Schistosoma mansoni	hypothetical protein	0.0045	0.0429	0.0428
Brugia malayi	beta-lactamase	0.0036	0.0279	0.1179
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0108	0.1439	0.1574
Trypanosoma cruzi	ISWI complex protein	0.0034	0.024	0.4297
Loa Loa (eye worm)	glycerol-3-phosphate dehydrogenase	0.0053	0.0557	0.0557
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0279	0.0306
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0461	0.0914
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0063	0.072	0.0788
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1617	0.1617
Echinococcus multilocularis	glycerol 3 phosphate dehydrogenase	0.0053	0.0557	0.1104
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0002	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0302	0.0301
Chlamydia trachomatis	D-amino acid dehydrogenase	0.0053	0.0557	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0415	0.0413
Brugia malayi	RE18450p	0.0053	0.0557	0.2358
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0037	0.0302	0.0301
Echinococcus granulosus	fetal alzheimer antigen falz	0.0049	0.0497	0.0985
Mycobacterium ulcerans	thiamine biosynthesis oxidoreductase ThiO	0.0053	0.0557	0.0557
Trypanosoma brucei	FAD dependent oxidoreductase, putative	0.0053	0.0557	1
Schistosoma mansoni	hypothetical protein	0.033	0.5032	0.5031
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0053	0.0557	0.0557
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0108	0.1439	0.1574
Trypanosoma brucei	ISWI complex protein	0.0034	0.024	0.4297
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0102	0.1397
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0108	0.1439	0.1351
Brugia malayi	beta-lactamase family protein	0.0036	0.0279	0.1179
Echinococcus granulosus	zinc finger protein	0.0043	0.0392	0.0776
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0279	0.0179
Toxoplasma gondii	hypothetical protein	0.0053	0.0557	0.7731
Echinococcus granulosus	muscleblind protein	0.0146	0.2061	0.4094
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.0461	0.0461
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1058	0.1058
Schistosoma mansoni	d-amino acid oxidase	0.0637	1	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0102	0.1397
Onchocerca volvulus	Putative fad oxidoreductase	0.0053	0.0557	0.3003
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial	0.0053	0.0557	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0063	0.072	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0002	0.0002
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0415	0.0821
Schistosoma mansoni	ATP:guanidino kinase (Smc74)	0.0053	0.0557	0.0555
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0002	0.0002
Loa Loa (eye worm)	PHD-finger family protein	0.0045	0.0429	0.0429
Brugia malayi	Muscleblind-like protein	0.0146	0.2061	0.8747
Leishmania major	glycerol-3-phosphate dehydrogenase-like protein	0.0053	0.0557	0.7731
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0557	0.0557
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0461	0.8284
Echinococcus multilocularis	zinc finger protein	0.0043	0.0392	0.0776
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0461	0.0914
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0279	0.0279
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.012	0.1633	0.1787
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0102	0.0102
Toxoplasma gondii	FAD-dependent glycerol-3-phosphate dehydrogenase	0.0053	0.0557	0.7731
Mycobacterium tuberculosis	Probable dehydrogenase	0.0108	0.1439	0.1574
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0002	0.0032
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0002	0.0032
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0108	0.1439	0.1574
Brugia malayi	hypothetical protein	0.0119	0.1617	0.6861
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0637	1	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0279	0.0306
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0102	0.1604
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0131	0.1814	0.3602
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0053	0.0557	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2061	0.2061
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0279	0.0552
Schistosoma mansoni	hypothetical protein	0.0034	0.024	0.0239
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0415	0.0413
Echinococcus multilocularis	muscleblind protein	0.0146	0.2061	0.4094
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0102	0.0102
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0037	0.0302	0.0301
Entamoeba histolytica	anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative	0.0053	0.0557	0.8878
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0102	0.0112
Leishmania major	hypothetical protein, conserved	0.0053	0.0557	0.7731
Toxoplasma gondii	aldehyde dehydrogenase	0.0063	0.072	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0102	0.0102
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0279	0.0306
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.0461	0.0505
Echinococcus granulosus	histone lysine methyltransferase setb	0.0037	0.0302	0.0598
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.072	0.072
Onchocerca volvulus		0.0036	0.0279	0.117
Trypanosoma brucei	electron transfer flavoprotein-ubiquinone oxidoreductase, putative	0.0053	0.0557	1
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase GlpD2	0.0053	0.0557	0.0557
Mycobacterium tuberculosis	Possible thiamine biosynthesis oxidoreductase ThiO	0.0053	0.0557	0.0609
Trichomonas vaginalis	esterase, putative	0.0036	0.0279	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0279	0.4999
Brugia malayi	Thioredoxin reductase	0.0047	0.0461	0.1953
Toxoplasma gondii	thioredoxin reductase	0.0047	0.0461	0.64
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0063	0.072	0.1428
Plasmodium vivax	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0053	0.0557	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.072	0.072
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0102	0.0102
Brugia malayi	Bromodomain containing protein	0.0084	0.1055	0.4476
Leishmania major	trypanothione reductase	0.0047	0.0461	0.64
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0102	0.0102
Onchocerca volvulus	Huntingtin homolog	0.0119	0.1617	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0131	0.1814	0.3602
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0108	0.1439	0.1574
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0279	1
Mycobacterium ulcerans	lipase LipD	0.0036	0.0279	0.0279
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0053	0.0557	1
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0102	0.0426
Echinococcus multilocularis	FAD dependent oxidoreductase domain containing protein	0.0053	0.0557	0.1104
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1142	0.1142
Schistosoma mansoni	fad oxidoreductase	0.0053	0.0557	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0279	0.0279
Plasmodium falciparum	FAD-dependent glycerol-3-phosphate dehydrogenase, putative	0.0053	0.0557	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0279	0.4999
Mycobacterium tuberculosis	Probable oxidoreductase	0.012	0.1633	0.1787
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0279	0.0279
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0279	0.0306
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0415	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0102	0.0102
Onchocerca volvulus	Huntingtin homolog	0.0119	0.1617	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0557	0.0557
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0049	0.0497	0.0985
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.012	0.1633	0.1547
Onchocerca volvulus	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog	0.0053	0.0557	0.3003
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0279	0.0279
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0461	0.8279
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0279	0.0306
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0037	0.0302	0.0598
Leishmania major	hypothetical protein, conserved	0.0053	0.0557	0.7731
Schistosoma mansoni	glycerol-3-phosphate dehydrogenase	0.0053	0.0557	0.0555
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0279	0.0279
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0279	0.0179
Echinococcus granulosus	FAD dependent oxidoreductase domain containing protein	0.0053	0.0557	0.1104
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0002	0.0002
Brugia malayi	pyruvate dehydrogenase phosphatase regulatory subunit precursor	0.0053	0.0557	0.2358
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0279	0.0278
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0279	0.0306
Mycobacterium tuberculosis	Probable reductase	0.0108	0.1439	0.1574
Echinococcus multilocularis	geminin	0.033	0.5032	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0302	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0557	0.0557
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0102	0.0426
Leishmania major	hypothetical protein, conserved	0.0034	0.024	0.3322
Schistosoma mansoni	aldehyde dehydrogenase	0.0063	0.072	0.0718
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0279	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0102	0.1604
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0279	0.0306
Trypanosoma cruzi	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0053	0.0557	1
Schistosoma mansoni	zinc finger protein	0.0034	0.024	0.0239
Trypanosoma cruzi	ISWI complex protein	0.0034	0.024	0.4297
Schistosoma mansoni	aldehyde dehydrogenase	0.0063	0.072	0.0718
Trypanosoma brucei	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0053	0.0557	1
Plasmodium falciparum	glutathione reductase	0.0047	0.0461	0.8284
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.2061	0.4094
Schistosoma mansoni	bromodomain containing protein	0.0139	0.194	0.1939
Trypanosoma cruzi	glycerol-3-phosphate dehydrogenase (FAD-dependent), putative	0.0053	0.0557	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0079	0.0971	0.1928
Trypanosoma brucei	trypanothione reductase	0.0047	0.0461	0.8279
Schistosoma mansoni	fad oxidoreductase	0.0053	0.0557	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0279	0.0279
Brugia malayi	beta-lactamase family protein	0.0036	0.0279	0.1179
Schistosoma mansoni	hypothetical protein	0.033	0.5032	0.5031
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0279	0.1179
Brugia malayi	PHD-finger family protein	0.0055	0.0581	0.246
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0037	0.0302	0.0598
Mycobacterium ulcerans	glycerol-3-phosphate dehydrogenase	0.0053	0.0557	0.0557
Trypanosoma brucei	L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative	0.0053	0.0557	1
Onchocerca volvulus	Dimethylglycine dehydrogenase, mitochondrial homolog	0.0053	0.0557	0.3003
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0461	0.8284
Mycobacterium leprae	Possible thiamine biosynthesis oxidoreductase ThiO	0.0053	0.0557	0.046
Loa Loa (eye worm)	glutathione reductase	0.0047	0.0461	0.0461
Giardia lamblia	Glycerol-3-phosphate dehydrogenase	0.0057	0.0627	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0279	0.0279
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0049	0.0497	0.0495
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0279	0.0552
Onchocerca volvulus		0.0036	0.0279	0.117
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0279	0.0279
Echinococcus granulosus	glycerol 3 phosphate dehydrogenase	0.0053	0.0557	0.1104
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0279	1
Brugia malayi	glutathione reductase	0.0047	0.0461	0.1953
Onchocerca volvulus		0.0036	0.0279	0.117
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.023	0.3411	0.3731
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0063	0.072	0.072
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 20	0.0053	0.0557	1
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0279	0.0279
Echinococcus granulosus	geminin	0.033	0.5032	1
Loa Loa (eye worm)	hypothetical protein	0.0155	0.2204	0.2204
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0102	0.0426
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0102	0.0102
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0279	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0079	0.0971	0.1928
Loa Loa (eye worm)	hypothetical protein	0.0146	0.2061	0.2061
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0063	0.072	0.1428
Brugia malayi	dimethylglycine dehydrogenase, mitochondrial precursor, putative	0.0053	0.0557	0.2358
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0102	0.1397
Brugia malayi	cDNA sequence BC016226	0.0053	0.0557	0.2358
Schistosoma mansoni	zinc finger protein	0.0043	0.0392	0.039
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0415	0.0413
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0279	0.0306
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0102	0.0102
Mycobacterium leprae	Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase)	0.0053	0.0557	0.046
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	0.0584	0.9141	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.012	0.1633	0.1787
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0279	0.0306
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0102	0.0102
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0037	0.0302	0.0301
Schistosoma mansoni	NAD dehydrogenase	0.0053	0.0557	0.0555
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0279	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1617	0.1617
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0037	0.0302	0.0598
Leishmania major	hypothetical protein, conserved	0.0036	0.0279	0.3865
Mycobacterium leprae	PROBABLE D-AMINO ACID OXIDASE AAO	0.0637	1	1
Brugia malayi	Bromodomain containing protein	0.0164	0.2356	1
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0461	0.8284
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0279	1
Toxoplasma gondii	ABC1 family protein	0.0036	0.0279	0.3865
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0415	0.0821
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0415	0.0415

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 611656