Detailed information for compound 619515

Basic information

Technical information
  • TDR Targets ID: 619515
  • Name: 5-[1-(2-hydroxyethyl)-2-phenyl-5,6,7,8-tetrah ydroquinolin-4-ylidene]-1,3-dimethyl-1,3-diaz inane-2,4,6-trione
  • MW: 407.462 | Formula: C23H25N3O4
  • H donors: 1 H acceptors: 4 LogP: 1.79 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCn1c(cc(=C2C(=O)N(C)C(=O)N(C2=O)C)c2c1CCCC2)c1ccccc1
  • InChi: 1S/C23H25N3O4/c1-24-21(28)20(22(29)25(2)23(24)30)17-14-19(15-8-4-3-5-9-15)26(12-13-27)18-11-7-6-10-16(17)18/h3-5,8-9,14,27H,6-7,10-13H2,1-2H3
  • InChiKey: DVCBHJGWCFNZLE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[1-(2-hydroxyethyl)-2-phenyl-5,6,7,8-tetrahydroquinolin-4-ylidene]-1,3-dimethyl-hexahydropyrimidine-2,4,6-trione
  • 5-[1-(2-hydroxyethyl)-2-phenyl-5,6,7,8-tetrahydroquinolin-4-ylidene]-1,3-dimethylhexahydropyrimidine-2,4,6-trione
  • 5-[1-(2-hydroxyethyl)-2-phenyl-5,6,7,8-tetrahydroquinolin-4-ylidene]-1,3-dimethyl-barbituric acid
  • ZINC02692968

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0058 0.0058
Trichomonas vaginalis glutaminase, putative 0.0297 0.3873 1
Schistosoma mansoni hypothetical protein 0.0037 0.0271 0.0271
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.1334 0.1334
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.004
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0271 0.7808
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0493 0.0493
Loa Loa (eye worm) hypothetical protein 0.0053 0.0505 0.0571
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.169 0.169
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0268 0.3473 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0314 0.0314
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0021 0.0058 0.0058
Schistosoma mansoni lipoxygenase 0.0116 0.1377 0.1377
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0003 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1157 0.1157
Brugia malayi MBOAT family protein 0.0021 0.0058 0.0065
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0314 0.0896
Echinococcus multilocularis muscleblind protein 0.0657 0.8852 0.8852
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0065
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0505 0.0571
Schistosoma mansoni lipoxygenase 0.0081 0.0892 0.0892
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.1157 0.1157
Brugia malayi beta-lactamase 0.0042 0.0346 0.0391
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0021 0.0058 0.0065
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0021 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0182 0.2279 0.2279
Schistosoma mansoni hypothetical protein 0.0019 0.0035 0.0035
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0346 0.0988
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0003 0.0004
Echinococcus granulosus zinc finger protein 0.0223 0.2858 0.2858
Echinococcus multilocularis lamin dm0 0.0029 0.0166 0.0166
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0042 0.0346 0.0391
Loa Loa (eye worm) hypothetical protein 0.0028 0.0159 0.0179
Trypanosoma cruzi GUP1, putative 0.0021 0.0058 0.1579
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.1334 0.1334
Echinococcus granulosus muscleblind protein 0.0657 0.8852 0.8852
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.1746 0.1972
Onchocerca volvulus 0.0042 0.0346 0.6792
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.1746 0.1746
Loa Loa (eye worm) MBOAT family protein 0.0244 0.3149 0.3557
Echinococcus multilocularis muscleblind protein 1 0.0657 0.8852 0.8852
Schistosoma mansoni hypothetical protein 0.0113 0.1334 0.1334
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0271 0.0271
Echinococcus multilocularis geminin 0.0182 0.2279 0.2279
Echinococcus granulosus sterol O acyltransferase 1 0.0021 0.0058 0.0058
Brugia malayi hypothetical protein 0.0019 0.0035 0.004
Schistosoma mansoni microtubule-associated protein tau 0.074 1 1
Loa Loa (eye worm) hypothetical protein 0.0657 0.8852 1
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0657 0.8852 1
Echinococcus granulosus RUN 0.0019 0.0035 0.0035
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0505 0.0571
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0271 0.7808
Loa Loa (eye worm) glutaminase 0.0297 0.3873 0.4376
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0314 0.062
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0021 0.0058 0.0058
Echinococcus granulosus neuropeptide receptor A26 0.0461 0.6146 0.6146
Onchocerca volvulus 0.0042 0.0346 0.6792
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0058 0.0065
Brugia malayi MBOAT family protein 0.0021 0.0058 0.0065
Loa Loa (eye worm) hhat protein 0.0021 0.0058 0.0065
Schistosoma mansoni rab6-interacting 0.0019 0.0035 0.0035
Brugia malayi Cytochrome P450 family protein 0.0023 0.0079 0.0089
Toxoplasma gondii hypothetical protein 0.0021 0.0058 0.157
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0314 0.0673
Brugia malayi intermediate filament protein 0.0029 0.0166 0.0188
Brugia malayi beta-lactamase family protein 0.0042 0.0346 0.0391
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0058 0.0058
Brugia malayi Doublecortin family protein 0.0019 0.0035 0.004
Brugia malayi hypothetical protein 0.0019 0.0035 0.004
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0003 0.0003
Schistosoma mansoni rab6-interacting 0.0019 0.0035 0.0035
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0346 0.0704
Loa Loa (eye worm) hypothetical protein 0.0042 0.0346 0.0391
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0271 0.056
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0058 0.1579
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0271 0.0271
Schistosoma mansoni loxhd1 0.0019 0.0035 0.0035
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0244 0.3149 0.3149
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0346 1
Brugia malayi beta-lactamase family protein 0.0042 0.0346 0.0391
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0058 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1157 0.1157
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0021 0.0058 0.0058
Mycobacterium tuberculosis Conserved protein 0.0042 0.0346 0.0988
Mycobacterium ulcerans lipase LipD 0.0042 0.0346 0.0704
Schistosoma mansoni zinc finger protein 0.0244 0.3149 0.3149
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0271 0.7808
Schistosoma mansoni ap endonuclease 0.004 0.0314 0.0314
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0346 0.0988
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0348 0.0762
Loa Loa (eye worm) hhat protein 0.0021 0.0058 0.0065
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0314 0.5
Leishmania major glycerol uptake protein, putative 0.0021 0.0058 0.1579
Mycobacterium ulcerans hypothetical protein 0.0042 0.0346 0.0704
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0346 0.0757
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0346 0.0391
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0021 0.0058 0.0058
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0166 0.0188
Brugia malayi MBOAT family protein 0.0021 0.0058 0.0065
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0035 0.0035
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0314 0.9018
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0058 0.0058
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.03 0.1898
Onchocerca volvulus 0.0042 0.0346 0.6792
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.1746 0.1746
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0346 0.0757
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0058 0.1579
Loa Loa (eye worm) hypothetical protein 0.0029 0.0166 0.0188
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0314 0.9069
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0481 0.0543
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0314 1
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.03 0.6614
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0079 0.0089
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0003 0.0003
Loa Loa (eye worm) glutaminase 2 0.0297 0.3873 0.4376
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0314 0.2013
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0021 0.0058 0.0058
Trypanosoma brucei glycerol uptake protein, putative 0.0021 0.0058 0.1579
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.1157 0.1307
Echinococcus granulosus lamin 0.0029 0.0166 0.0166
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0021 0.0058 0.157
Schistosoma mansoni glutaminase 0.0297 0.3873 0.3873
Brugia malayi Muscleblind-like protein 0.0657 0.8852 1
Leishmania major hypothetical protein, conserved 0.0021 0.0058 0.1579
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.1157 0.1157
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0346 0.0346
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0058 0.1579
Echinococcus granulosus geminin 0.0182 0.2279 0.2279
Brugia malayi MBOAT family protein 0.0021 0.0058 0.0065
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0346 0.0391
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0035 0.0035
Schistosoma mansoni ap endonuclease 0.004 0.0314 0.0314
Echinococcus multilocularis RUN 0.0019 0.0035 0.0035
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0116 0.1377 0.1377
Mycobacterium tuberculosis Conserved protein 0.0042 0.0346 0.0988
Mycobacterium ulcerans beta-lactamase 0.0042 0.0346 0.0704
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0271 0.1674
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0346 0.0757
Onchocerca volvulus 0.0053 0.0493 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.1334 0.1334
Brugia malayi follicle stimulating hormone receptor 0.0254 0.3279 0.3704
Leishmania major glycerol uptake protein, putative 0.0021 0.0058 0.1579
Brugia malayi isocitrate dehydrogenase 0.0017 0.0003 0.0004
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0035 0.1027
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0058 0.0065
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 0.3279 0.3704
Schistosoma mansoni polycystin 1-related 0.0019 0.0035 0.0035
Echinococcus multilocularis microtubule associated protein 2 0.074 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0271 0.056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0271 0.0307
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0003 0.0003
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0003 0.0004
Echinococcus multilocularis musashi 0.0029 0.0166 0.0166
Toxoplasma gondii exonuclease III APE 0.004 0.0314 0.9018
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0314 0.9069
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0021 0.0058 0.0058
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0505 0.0571
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0314 0.0673
Echinococcus multilocularis sterol O acyltransferase 1 0.0021 0.0058 0.0058
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0058 0.0058
Brugia malayi diacylglycerol acyltransferase 0.0021 0.0058 0.0065
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0346 0.0704
Brugia malayi Cytochrome P450 family protein 0.0052 0.0481 0.0543
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0065
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0271 0.0307
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0346 0.0988
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0003 0.0003
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0348 1
Toxoplasma gondii ABC1 family protein 0.0042 0.0346 0.9944
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0346 0.0988
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0346 0.0988
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0021 0.0058 0.0058
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0079 0.2206
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0348 0.0348
Entamoeba histolytica hypothetical protein 0.0113 0.1334 1
Leishmania major cytochrome p450-like protein 0.0023 0.0079 0.2206
Loa Loa (eye worm) hypothetical protein 0.0053 0.0493 0.0557
Loa Loa (eye worm) hypothetical protein 0.0042 0.0346 0.0391
Loa Loa (eye worm) hypothetical protein 0.0042 0.0346 0.0391
Brugia malayi Hhat protein 0.0021 0.0058 0.0065
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1157 0.1157
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0346 0.0988
Schistosoma mansoni lamin 0.0029 0.0166 0.0166
Mycobacterium tuberculosis Conserved protein 0.0042 0.0346 0.0988
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0271 0.056
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0271 0.0271
Leishmania major glycerol uptake protein, putative 0.0021 0.0058 0.1579
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0021 0.0058 0.0058
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0035 0.0035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0346 0.0346
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0035 0.0035
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0346 0.0757
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0271 0.0271
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0271 0.0306
Onchocerca volvulus 0.0021 0.0058 0.0485
Entamoeba histolytica hypothetical protein 0.0113 0.1334 1
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0244 0.3149 0.3149
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0079 0.0089
Echinococcus granulosus intermediate filament protein 0.0029 0.0166 0.0166
Schistosoma mansoni sterol O-acyltransferase 1 0.0021 0.0058 0.0058
Leishmania major glycerol uptake protein, putative 0.0021 0.0058 0.1579
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0314 1
Entamoeba histolytica hypothetical protein 0.0113 0.1334 1
Brugia malayi glutaminase DH11.1 0.0297 0.3873 0.4376
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0035 0.0035
Mycobacterium ulcerans glutaminase 0.0297 0.3873 1
Leishmania major glycerol uptake protein, putative 0.0021 0.0058 0.1579
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0314 0.0355
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0021 0.0058 0.0065
Echinococcus granulosus neuropeptide s receptor 0.0461 0.6146 0.6146
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.004
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0314 0.9069
Echinococcus multilocularis neuropeptide receptor A26 0.0461 0.6146 0.6146
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0271 0.0271
Trypanosoma brucei glycerol uptake protein, putative 0.0021 0.0058 0.1579
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0348 1
Echinococcus granulosus lamin dm0 0.0029 0.0166 0.0166
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0271 0.0271
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.03 0.9529
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0346 0.5
Loa Loa (eye worm) acetyltransferase 0.0143 0.1746 0.1972
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0346 0.0988
Leishmania major hypothetical protein, conserved 0.0042 0.0346 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0003 0.0003
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0271 0.0271
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0116 0.1377 0.1377
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0079 0.0089
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0166 0.0188
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0314 0.0355
Echinococcus granulosus tumor protein p63 0.0359 0.4734 0.4734
Brugia malayi MBOAT family protein 0.0244 0.3149 0.3557
Echinococcus multilocularis tumor protein p63 0.0359 0.4734 0.4734
Trichomonas vaginalis esterase, putative 0.0042 0.0346 0.0757
Loa Loa (eye worm) beta-lactamase 0.0042 0.0346 0.0391
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0348 1
Schistosoma mansoni hypothetical protein 0.0182 0.2279 0.2279
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.1157 0.1157
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0035 0.004
Brugia malayi Cytochrome P450 family protein 0.0023 0.0079 0.0089
Schistosoma mansoni lamin 0.0029 0.0166 0.0166
Echinococcus multilocularis neuropeptide s receptor 0.0461 0.6146 0.6146
Mycobacterium leprae Probable lipase LipE 0.0042 0.0346 0.5
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0079 0.2206
Schistosoma mansoni intermediate filament proteins 0.0029 0.0166 0.0166
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0058 0.0058
Echinococcus multilocularis lamin 0.0029 0.0166 0.0166
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.1157 0.1157
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0065
Onchocerca volvulus 0.0029 0.0166 0.2853
Loa Loa (eye worm) hypothetical protein 0.0037 0.0271 0.0306
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0035 0.0926
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0021 0.0058 0.0058
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0346 1
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0021 0.0058 0.0058
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0348 0.0762
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0314 0.9069
Onchocerca volvulus 0.0029 0.0166 0.2853
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0065
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0346 0.0757
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.1157 0.1307
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0346 1
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0021 0.0058 0.157
Echinococcus multilocularis zinc finger protein 0.0223 0.2858 0.2858
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0166 0.0188
Entamoeba histolytica hypothetical protein 0.0113 0.1334 1
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0346 0.9944
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0314 0.0314
Trypanosoma cruzi GUP1, putative 0.0021 0.0058 0.1579
Loa Loa (eye worm) hypothetical protein 0.0042 0.0346 0.0391
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0042 0.0346 0.0391
Brugia malayi hypothetical protein 0.0113 0.1334 0.1506
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0021 0.0058 0.157
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0021 0.0058 0.0058
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0346 0.0346
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0058 0.0058
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0021 0.0058 0.1741
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0271 0.7808
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0314 1
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0079 0.2206
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0346 0.0346
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0271 0.0271

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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