Detailed information for compound 632110

Basic information

Technical information
  • TDR Targets ID: 632110
  • Name: 1,3,7-trimethyl-8-(2-phenylethylamino)purine- 2,6-dione
  • MW: 313.354 | Formula: C16H19N5O2
  • H donors: 1 H acceptors: 3 LogP: 1.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1c(NCCc2ccccc2)nc2c1c(=O)n(c(=O)n2C)C
  • InChi: 1S/C16H19N5O2/c1-19-12-13(20(2)16(23)21(3)14(12)22)18-15(19)17-10-9-11-7-5-4-6-8-11/h4-8H,9-10H2,1-3H3,(H,17,18)
  • InChiKey: PDMRCZKKXHBCCP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1,3,7-trimethyl-8-(2-phenylethylamino)xanthine
  • 7499-93-6
  • ZINC00280496
  • Oprea1_060015
  • NSC400066
  • IDI1_002551
  • 1,3,7-Trimethyl-8-phenethylamino-3,7-dihydro-purine-2,6-dione
  • BAS 04239156
  • BIM-0046916.P001
  • A2344/0098978
  • CBMicro_046949
  • ChemDiv2_003836

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens monoamine oxidase B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi amine oxidase, flavin-containing family protein monoamine oxidase B 520 aa 462 aa 19.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0072 0.0201
Schistosoma mansoni lamin 0.0053 0.0326 0.0535
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0072 0.0201
Giardia lamblia Lysyl-tRNA synthetase 0.0069 0.0448 0.6849
Echinococcus granulosus survival motor neuron protein 1 0.0476 0.3569 0.5854
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0026 0.0042
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0044 0.0252 0.0819
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0108 0.0749 1
Echinococcus multilocularis 0.0025 0.0112 0.0183
Leishmania major protein kinase, putative 0.0095 0.0645 0.8619
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0161 0.0264
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0093 0.0631 0.1034
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0161 0.2153
Echinococcus granulosus lamin dm0 0.0053 0.0326 0.0535
Brugia malayi Importin beta-1 subunit 0.0057 0.0352 0.0986
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0095 0.0646 0.0974
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0115 0.0189
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.005 0.0141
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0016 0.0071
Loa Loa (eye worm) hypothetical protein 0.0052 0.0319 0.07
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0252 0.1099
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0115 0.0189
Trichomonas vaginalis importin beta-1, putative 0.0046 0.027 0.1176
Brugia malayi hypothetical protein 0.0049 0.0291 0.0816
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0377 0.0569
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0017 0.0052 0.0059
Plasmodium vivax hexose transporter 0.0309 0.2293 0.2293
Giardia lamblia Hexose transporter 0.0044 0.0252 0.346
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0496 0.0496
Schistosoma mansoni amine oxidase 0.0025 0.0112 0.0183
Plasmodium vivax CDK-related protein kinase 6, putative 0.1313 1 1
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Onchocerca volvulus 0.0053 0.0326 0.4306
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0237 0.0389
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.05 0.3756 0.5666
Mycobacterium ulcerans dehydrogenase 0.0025 0.0112 0.0288
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0352 0.47
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0496 0.6458
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0017 0.0052 0.0262
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.0838 0.1375
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0044 0.0252 0.3365
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0161 0.0264
Schistosoma mansoni protein kinase 0.0095 0.0645 0.1059
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Echinococcus multilocularis lamin dm0 0.0053 0.0326 0.0535
Brugia malayi major facilitator superfamily protein 0.0044 0.0252 0.0706
Leishmania major hypothetical protein, conserved 0.0015 0.0036 0.0481
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0095 0.0645 0.1059
Schistosoma mansoni lysyl-tRNA synthetase 0.0069 0.0448 0.0735
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0069 0.0448 0.1564
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Loa Loa (eye worm) hypothetical protein 0.0075 0.0497 0.1092
Echinococcus granulosus transient receptor potential ion channel A 0.028 0.2065 0.3388
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0177 0.0291
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0237 0.2824
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0161 0.2153
Plasmodium vivax threonine--tRNA ligase, putative 0.0017 0.0052 0.0052
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0352 0.0531
Leishmania major hypothetical protein, conserved 0.0044 0.0252 0.3365
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Loa Loa (eye worm) hypothetical protein 0.0075 0.0496 0.1091
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0069 0.0448 0.1954
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0267 0.0587
Toxoplasma gondii lysine-tRNA ligase 0.0069 0.0448 0.0676
Schistosoma mansoni thyroid hormone receptor 0.002 0.0072 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0017 0.0052 0.0145
Onchocerca volvulus 0.0097 0.0663 1
Trichomonas vaginalis sugar transporter, putative 0.0096 0.0655 0.2854
Echinococcus granulosus importin subunit beta 1 0.0057 0.0352 0.0577
Echinococcus granulosus calcium activated potassium channel 0.0016 0.0037 0.0061
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0044 0.0252 0.0413
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0108 0.0749 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0025 0.0112 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0052 0.0086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0072 0.0118
Echinococcus multilocularis solute carrier family 22 0.0044 0.0252 0.0413
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Loa Loa (eye worm) hypothetical protein 0.0102 0.0704 0.1548
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0236
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0161 0.1756
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0025 0.0112 0.1274
Plasmodium falciparum calcium-dependent protein kinase 1 0.0095 0.0646 0.0646
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0072 0.0201
Schistosoma mansoni coup transcription factor 0.002 0.0072 0.0118
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0017 0.0052 0.0225
Giardia lamblia Prolyl-tRNA synthetase 0.0093 0.0631 1
Echinococcus granulosus snurportin 1 0.0603 0.455 0.7464
Schistosoma mansoni hypothetical protein 0.0805 0.6096 1
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Trypanosoma brucei THT1 - hexose transporter, putative 0.0096 0.0655 0.8744
Brugia malayi lysyl-tRNA synthetase 0.0069 0.0448 0.1256
Brugia malayi Sugar transporter family protein 0.0044 0.0252 0.0706
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0072 0.0118
Brugia malayi Sugar transporter family protein 0.0044 0.0252 0.0706
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0017 0.0052 0.0218
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0377 0.1294
Brugia malayi hypothetical protein 0.0044 0.0252 0.0706
Trichomonas vaginalis glucose transporter, putative 0.0044 0.0252 0.1099
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0158
Toxoplasma gondii sugar transporter ST2 0.0044 0.0252 0.038
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0095 0.0645 0.1059
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0377 0.0618
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0016 0.0071
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0017 0.0052 0.0145
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0267 0.0438
Plasmodium falciparum hexose transporter 0.0309 0.2293 0.2293
Echinococcus granulosus solute carrier family 22 0.0044 0.0252 0.0413
Brugia malayi hypothetical protein 0.0075 0.0496 0.1391
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0161 0.0243
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0093 0.0631 0.1034
Echinococcus multilocularis geminin 0.0167 0.1199 0.1967
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0052 0.0086
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0309 0.2293 0.3762
Entamoeba histolytica Ran family GTPase 0.0042 0.0237 0.3677
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0095 0.0646 0.0646
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0072 0.0118
Onchocerca volvulus 0.0044 0.0252 0.3049
Echinococcus multilocularis protoporphyrinogen oxidase 0.0025 0.0112 0.0183
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0161 0.0452
Onchocerca volvulus 0.0044 0.0252 0.3049
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0108 0.0749 1
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Schistosoma mansoni nuclear hormone receptor 0.002 0.0072 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0036 0.0157
Echinococcus multilocularis solute carrier family 22 0.0044 0.0252 0.0413
Echinococcus multilocularis dnaJ subfamily B 0.0805 0.6096 1
Echinococcus granulosus General substrate transporter 0.0266 0.1959 0.3214
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0158
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0059 0.0368 0.1361
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0036 0.0157
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0095 0.0645 0.1059
Schistosoma mansoni hypothetical protein 0.0047 0.0282 0.0463
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0072 0.0118
Trypanosoma cruzi sugar transporter, putative 0.0044 0.0252 0.303
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0108 0.0749 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0072 0.0201
Toxoplasma gondii LsmAD domain-containing protein 0.0075 0.0496 0.0749
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0377 0.0618
Mycobacterium ulcerans monoamine oxidase 0.0025 0.0112 0.0288
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0095 0.0645 0.1418
Plasmodium falciparum calcium-dependent protein kinase 5 0.0095 0.0646 0.0646
Schistosoma mansoni transient receptor potential channel 0.0289 0.2139 0.3509
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0072 0.0118
Leishmania major lysyl-tRNA synthetase, putative 0.0069 0.0448 0.5986
Trypanosoma cruzi hexose transporter, putative 0.0096 0.0655 0.868
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Echinococcus multilocularis short transient receptor potential channel 6 0.0191 0.1387 0.2276
Leishmania major hypothetical protein, conserved 0.0015 0.0036 0.0481
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0072 0.0118
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0017 0.0052 0.0218
Trypanosoma cruzi UDP-galactopyranose mutase 0.0025 0.0112 0.1063
Schistosoma mansoni ran 0.0042 0.0237 0.0389
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0059 0.0368 0.5587
Onchocerca volvulus 0.0044 0.0252 0.3049
Onchocerca volvulus 0.0044 0.0252 0.3049
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0282 0.079
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0095 0.0645 0.1059
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0112 0.0112
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0282 0.0463
Brugia malayi hypothetical protein 0.0044 0.0252 0.0706
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0267 0.0438
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Echinococcus granulosus lysine specific histone demethylase 1A 0.0025 0.0112 0.0183
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0017 0.0052 0.0085
Leishmania major importin beta-1 subunit, putative 0.0046 0.027 0.3603
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0352 0.0577
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0072 0.0158
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0095 0.0646 0.0646
Echinococcus granulosus cpg binding protein 0.006 0.0376 0.0618
Toxoplasma gondii histone lysine-specific demethylase 0.0025 0.0112 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0252 0.1099
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0113
Brugia malayi isocitrate dehydrogenase 0.0032 0.0161 0.0452
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Echinococcus granulosus geminin 0.0167 0.1199 0.1967
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0377 0.5036
Trypanosoma brucei glucose transporter, putative 0.0096 0.0655 0.8744
Onchocerca volvulus 0.0044 0.0252 0.3049
Leishmania major GTP-binding protein, putative 0.0042 0.0237 0.3169
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0137 0.03
Echinococcus multilocularis lysyl tRNA synthetase 0.0069 0.0448 0.0735
Loa Loa (eye worm) hypothetical protein 0.0057 0.0352 0.0773
Plasmodium falciparum calcium-dependent protein kinase 4 0.0095 0.0646 0.0646
Brugia malayi Cam kinase protein 1 0.0095 0.0645 0.1808
Schistosoma mansoni intermediate filament proteins 0.0053 0.0326 0.0535
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0072 0.0201
Schistosoma mansoni survival motor neuron protein 0.0097 0.0663 0.1087
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0072 0.0158
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0072 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0072 0.0201
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0237 0.0358
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Echinococcus granulosus transient receptor potential gamma protein 0.0289 0.2139 0.3509
Schistosoma mansoni glycyl-tRNA synthetase 0.0017 0.0052 0.0085
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0072 0.0118
Schistosoma mansoni sugar transporter 0.0044 0.0252 0.0413
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0017 0.0052 0.0059
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0112 0.0112
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0237 0.2824
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0072 0.0118
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0161 0.0243
Giardia lamblia Sugar-proton symporter 0.0044 0.0252 0.346
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0017 0.0052 0.0689
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Schistosoma mansoni protein kinase 0.0095 0.0645 0.1059
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0095 0.0645 0.1059
Treponema pallidum prolyl-tRNA synthetase 0.0033 0.017 1
Schistosoma mansoni protein kinase 0.0095 0.0645 0.1059
Trypanosoma brucei glucose transporter, putative 0.0096 0.0655 0.8744
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0645 0.1059
Trichomonas vaginalis glucose transporter, putative 0.0096 0.0655 0.2854
Brugia malayi nuclear hormone receptor 0.002 0.0072 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0036 0.0157
Trypanosoma brucei glucose transporter, putative 0.0096 0.0655 0.8744
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0237 0.0389
Schistosoma mansoni sugar transporter 0.0044 0.0252 0.0413
Echinococcus granulosus Threonyl tRNA synthetase C 0.0017 0.0052 0.0085
Brugia malayi hypothetical protein 0.0476 0.3569 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0645 0.1418
Plasmodium vivax sugar transporter, putative 0.0044 0.0252 0.0252
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0072 0.0201
Trypanosoma cruzi hexose transporter, putative 0.0044 0.0252 0.303
Schistosoma mansoni hypothetical protein 0.0167 0.1199 0.1967
Trypanosoma brucei THT1 - hexose transporter, putative 0.0096 0.0655 0.8744
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0072 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0282 0.079
Toxoplasma gondii transporter, major facilitator family protein 0.0044 0.0252 0.038
Loa Loa (eye worm) hypothetical protein 0.015 0.1068 0.2348
Echinococcus multilocularis survival motor neuron protein 1 0.0476 0.3569 0.5854
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0072 0.0158
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Onchocerca volvulus 0.0044 0.0252 0.3049
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0093 0.0631 0.9772
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0158
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0237 0.0521
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0017 0.0052 0.0689
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0326 0.0914
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0095 0.0645 0.1059
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.1068 0.2994
Schistosoma mansoni glucose transport protein 0.0309 0.2293 0.3762
Onchocerca volvulus 0.0044 0.0252 0.3049
Echinococcus granulosus neuropeptide receptor A26 0.046 0.345 0.5659
Schistosoma mansoni hypothetical protein 0.0603 0.455 0.7464
Mycobacterium tuberculosis Conserved hypothetical protein 0.0025 0.0112 0.031
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0377 0.0618
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0112 0.031
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0033 0.017 0.0507
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Brugia malayi Major Facilitator Superfamily protein 0.0044 0.0252 0.0706
Loa Loa (eye worm) hypothetical protein 0.0047 0.0282 0.062
Mycobacterium ulcerans sugar transporter 0.0044 0.0252 0.0819
Brugia malayi steroid hormone receptor 0.002 0.0072 0.0201
Plasmodium falciparum mitogen-activated protein kinase 2 0.05 0.3756 0.3756
Echinococcus granulosus lysine specific histone demethylase 1A 0.0025 0.0112 0.0183
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.027 0.328
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0161 0.0161
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0069 0.0448 0.1564
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0072 0.0201
Trypanosoma cruzi UDP-galactopyranose mutase 0.0025 0.0112 0.1063
Schistosoma mansoni sugar transporter 0.0044 0.0252 0.0413
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0309 0.2293 0.3762
Onchocerca volvulus 0.0053 0.0326 0.4306
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Schistosoma mansoni importin beta-1 0.0057 0.0352 0.0577
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0246
Loa Loa (eye worm) hypothetical protein 0.0069 0.0448 0.0985
Leishmania major myo-inositol/proton symporter (MIT) 0.0044 0.0252 0.3365
Toxoplasma gondii sugar transporter ST3 0.0044 0.0252 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Brugia malayi Major Facilitator Superfamily protein 0.0044 0.0252 0.0706
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0072 0.0158
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0237 0.3207
Trypanosoma brucei THT1 - hexose transporter, putative 0.0096 0.0655 0.8744
Leishmania major glucose transporter, lmgt3 0.0096 0.0655 0.8744
Brugia malayi ecdysteroid receptor 0.002 0.0072 0.0201
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0016 0.0071
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0108 0.0744 0.1221
Trypanosoma brucei glucose transporter 1E 0.0096 0.0655 0.8744
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0072 0.0118
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0237 0.0665
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0496 0.6458
Onchocerca volvulus 0.0044 0.0252 0.3049
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0026 0.0042
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0158
Trypanosoma brucei glucose transporter, putative 0.0096 0.0655 0.8744
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0282 0.0463
Echinococcus multilocularis neuropeptide s receptor 0.046 0.345 0.5659
Onchocerca volvulus 0.0044 0.0252 0.3049
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 0.2671 1
Trypanosoma cruzi hexose transporter, putative 0.0096 0.0655 0.868
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0158
Entamoeba histolytica protein kinase, putative 0.0095 0.0645 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Brugia malayi major facilitator superfamily protein 0.0044 0.0252 0.0706
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0044 0.0252 1
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0072 0.0201
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Trypanosoma brucei glucose transporter 2A 0.0096 0.0655 0.8744
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0026 0.0042
Toxoplasma gondii histone lysine methyltransferase SET1 0.0107 0.074 0.1116
Loa Loa (eye worm) hypothetical protein 0.0182 0.1313 0.2886
Echinococcus granulosus synaptic vesicle 2 protein 0.0044 0.0252 0.0413
Trypanosoma cruzi hexose transporter, putative 0.0052 0.0321 0.3994
Toxoplasma gondii glycyl-tRNA synthetase 0.0017 0.0052 0.0078
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0044 0.0252 0.0885
Echinococcus granulosus calcium dependent protein kinase 0.0089 0.06 0.0985
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Onchocerca volvulus 0.0025 0.0112 0.0677
Trypanosoma cruzi glucose transporter, putative 0.0044 0.0252 0.303
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0072 0.0118
Echinococcus granulosus dnaJ subfamily B 0.0805 0.6096 1
Plasmodium vivax importin-beta 2, putative 0.0057 0.0352 0.0352
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0016 0.0071
Loa Loa (eye worm) hypothetical protein 0.0093 0.0631 0.1386
Schistosoma mansoni cpg binding protein 0.006 0.0376 0.0618
Echinococcus granulosus Sugar transporter ERD6 protein 0.0044 0.0252 0.0413
Brugia malayi Major Facilitator Superfamily protein 0.0044 0.0252 0.0706
Trichomonas vaginalis sugar transport protein, putative 0.0044 0.0252 0.1099
Trypanosoma brucei glucose transporter, putative 0.0096 0.0655 0.8744
Leishmania major UDP-galactopyranose mutase 0.0025 0.0112 0.1493
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0072 0.0118
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0017 0.0052 0.0113
Toxoplasma gondii sugar transporter ST1 0.0044 0.0252 0.038
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0025 0.0112 0.0183
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0377 0.1294
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0267 0.0438
Onchocerca volvulus 0.0044 0.0252 0.3049
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.05 0.3756 0.3756
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0252 0.1099
Schistosoma mansoni transient receptor potential channel 0.0191 0.1387 0.2276
Plasmodium falciparum protoporphyrinogen oxidase 0.0025 0.0112 0.0112
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0377 0.1397
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0309 0.2293 0.3762
Schistosoma mansoni cpg binding protein 0.0057 0.0352 0.0577
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0246
Loa Loa (eye worm) hypothetical protein 0.0053 0.0326 0.0717
Trichomonas vaginalis ran, putative 0.0042 0.0237 0.1035
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0158
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0061 0.0383 0.1669
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0095 0.0645 0.1059
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0161 0.0264
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0177 0.0291
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0072 0.0118
Trypanosoma brucei glucose transporter, putative 0.0096 0.0655 0.8744
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0655 0.2854
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0044 0.0252 0.0252
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Loa Loa (eye worm) hypothetical protein 0.0026 0.0115 0.0253
Echinococcus granulosus solute carrier family 22 0.0044 0.0252 0.0413
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0044 0.0252 0.0413
Trypanosoma cruzi hexose transporter 0.0096 0.0655 0.868
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0377 0.0618
Echinococcus multilocularis solute carrier family 22 0.0044 0.0252 0.0413
Schistosoma mansoni hypothetical protein 0.0167 0.1199 0.1967
Onchocerca volvulus 0.0044 0.0252 0.3049
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0072 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0252 0.1099
Echinococcus multilocularis General substrate transporter 0.0266 0.1959 0.3214
Schistosoma mansoni glucose transport protein 0.0309 0.2293 0.3762
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0095 0.0646 0.0974
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0309 0.2293 0.3762
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0017 0.0052 0.0064
Onchocerca volvulus 0.0044 0.0252 0.3049
Chlamydia trachomatis lysine--tRNA ligase 0.0069 0.0448 1
Trypanosoma brucei glucose transporter, putative 0.0096 0.0655 0.8744
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0161 0.0264
Schistosoma mansoni hypothetical protein 0.0102 0.0704 0.1156
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0326 0.0717
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0017 0.0052 0.0799
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0237 0.0237
Trypanosoma cruzi hexose transporter, putative 0.0096 0.0655 0.868
Schistosoma mansoni hypothetical protein 0.0097 0.0663 0.1087
Plasmodium falciparum threonine--tRNA ligase 0.0017 0.0052 0.0052
Trichomonas vaginalis helicase, putative 0.0013 0.0016 0.0071
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0072 0.0118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0267 0.0438
Trypanosoma brucei PAB1-binding protein , putative 0.0075 0.0496 0.6628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0072 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0025 0.0112 0.0183
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0072 0.0118
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0072 0.0118
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0016 0.0071
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Toxoplasma gondii protein kinase, putative 0.0874 0.6629 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0161 0.0264
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0309 0.2293 0.3762
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0072 0.0158
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0072 0.0118
Schistosoma mansoni hypothetical protein 0.0047 0.0282 0.0463
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0161 0.0513
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0069 0.0448 0.5783
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0093 0.0631 0.275
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0072 0.0118
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0052 0.0115
Brugia malayi Sugar transporter family protein 0.0309 0.2293 0.6427
Echinococcus granulosus lysyl tRNA synthetase 0.0069 0.0448 0.0735
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0158
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0309 0.2293 0.3762
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0108 0.0749 0.1129
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0267 0.0438
Plasmodium falciparum calcium-dependent protein kinase 2 0.0095 0.0646 0.0646
Echinococcus multilocularis neuropeptide receptor A26 0.046 0.345 0.5659
Echinococcus granulosus solute carrier family 22 0.0044 0.0252 0.0413
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0352 0.0773
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0236
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0093 0.0631 0.1034
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Echinococcus granulosus glycyl tRNA synthetase 0.0017 0.0052 0.0085
Plasmodium falciparum calcium-dependent protein kinase 3 0.0095 0.0646 0.0646
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0237 0.0237
Leishmania major glucose transporter/membrane transporter D2, putative 0.0096 0.0655 0.8744
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0015 0.0036 0.0481
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0158
Onchocerca volvulus 0.0044 0.0252 0.3049
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0059 0.0368 0.1361
Echinococcus granulosus FTZ F1 alpha 0.002 0.0072 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0309 0.2293 1
Schistosoma mansoni amine oxidase 0.0025 0.0112 0.0183
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0072 0.0201
Onchocerca volvulus 0.0044 0.0252 0.3049
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0095 0.0646 0.0646
Echinococcus granulosus solute carrier family 22 0.0044 0.0252 0.0413
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0095 0.0645 0.1059
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Brugia malayi CXXC zinc finger family protein 0.0057 0.0352 0.0986
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0016 0.0071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0246
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0025 0.0112 0.0288
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Echinococcus granulosus neuropeptide s receptor 0.046 0.345 0.5659
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0095 0.0645 0.1808
Mycobacterium ulcerans integral membrane transport protein 0.0044 0.0252 0.0819
Loa Loa (eye worm) hypothetical protein 0.0098 0.067 0.1472
Toxoplasma gondii facilitative glucose transporter GT1 0.0309 0.2293 0.3459
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0026 0.0042
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0017 0.0052 0.0078
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0025 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Echinococcus multilocularis calcium dependent protein kinase 0.0089 0.06 0.0985
Leishmania major hypothetical protein, conserved 0.0075 0.0496 0.6628
Entamoeba histolytica hypothetical protein 0.0046 0.027 0.4181
Brugia malayi intermediate filament protein 0.0053 0.0326 0.0914
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0704 0.1974
Schistosoma mansoni sugar transporter 0.0044 0.0252 0.0413
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0333 0.2477 1
Echinococcus granulosus short transient receptor potential channel 6 0.0191 0.1387 0.2276
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0029 0.0138 0.0209
Echinococcus granulosus intermediate filament protein 0.0053 0.0326 0.0535
Schistosoma mansoni transient receptor potential channel 0.0191 0.1387 0.2276
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0496 0.0496
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0267 0.0749
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0072 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0072 0.0201
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0072 0.0118
Entamoeba histolytica hypothetical protein 0.0069 0.0448 0.6945
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0267 0.0438
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0246
Echinococcus multilocularis short transient receptor potential channel 6 0.0191 0.1387 0.2276
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0282 0.062
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0072 0.0201
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0095 0.0645 0.8619
Entamoeba histolytica protein kinase, putative 0.0095 0.0645 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0044 0.0252 0.0554
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0017 0.0045 0.0607
Schistosoma mansoni hypothetical protein 0.0309 0.2293 0.3762
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Schistosoma mansoni hypothetical protein 0.0047 0.0282 0.0463
Loa Loa (eye worm) sugar transporter 0.0309 0.2293 0.504
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0069 0.0448 0.6932
Schistosoma mansoni lamin 0.0053 0.0326 0.0535
Trichomonas vaginalis sugar transporter, putative 0.0096 0.0655 0.2854
Brugia malayi Transient-receptor-potential like protein 0.0108 0.0744 0.2085
Schistosoma mansoni thyroid hormone receptor 0.002 0.0072 0.0118
Mycobacterium ulcerans oxidoreductase 0.0025 0.0112 0.0288
Schistosoma mansoni cpg binding protein 0.006 0.0376 0.0618
Plasmodium vivax glycine--tRNA ligase, putative 0.0017 0.0052 0.0052
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0093 0.0631 1
Loa Loa (eye worm) hypothetical protein 0.0476 0.3569 0.7843
Brugia malayi amine oxidase, flavin-containing family protein 0.0025 0.0112 0.0313
Echinococcus granulosus TRP transient receptor potential channel 0.0108 0.0744 0.1221
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0044 0.0252 0.0885
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Schistosoma mansoni hypothetical protein 0.0047 0.0282 0.0463
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.1068 0.2348
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0093 0.0631 0.1034
Echinococcus multilocularis GPCR, family 2 0.0047 0.0282 0.0463
Plasmodium vivax ataxin-2 like protein, putative 0.0075 0.0496 0.0496
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0017 0.0052 0.0799
Brugia malayi nuclear receptor NHR-88 0.002 0.0072 0.0201
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0072 0.0118
Plasmodium falciparum importin beta, putative 0.0057 0.0352 0.0352
Echinococcus multilocularis cpg binding protein 0.006 0.0376 0.0618
Trypanosoma brucei glucose transporter, putative 0.0096 0.0655 0.8744
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.027 0.1176
Schistosoma mansoni glucose transporter 0.0044 0.0252 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0072 0.0201
Echinococcus multilocularis calcium activated potassium channel 0.0016 0.0037 0.0061
Trypanosoma brucei sugar transporter, putative 0.0044 0.0252 0.3365
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0026 0.0042
Chlamydia trachomatis proline--tRNA ligase 0.0033 0.017 0.2978
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Onchocerca volvulus 0.0044 0.0252 0.3049
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0282 0.0463
Onchocerca volvulus 0.0057 0.0352 0.4738
Schistosoma mansoni ran 0.0042 0.0237 0.0389
Chlamydia trachomatis protoporphyrinogen oxidase 0.0025 0.0112 0.1519
Plasmodium falciparum lysine--tRNA ligase 0.0069 0.0448 0.0448
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0072 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0252 0.1099
Leishmania major glucose transporter, lmgt2 0.0096 0.0655 0.8744
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0161 0.0264
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0072 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0072 0.0201
Schistosoma mansoni hypothetical protein 0.0034 0.0177 0.0291
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.0112 0.0112
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0025 0.0112 0.0183
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0095 0.0646 0.0974
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0108 0.0749 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0069 0.0448 0.5986
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0326 0.0717
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0161 0.2153
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0093 0.0631 0.1767
Loa Loa (eye worm) hypothetical protein 0.0108 0.0744 0.1635
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0161 0.0264
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0237 0.3169
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0072 0.0118
Plasmodium falciparum proline--tRNA ligase 0.0108 0.0749 0.0749
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0072 0.0118
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0352 0.47
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0072 0.0118
Loa Loa (eye worm) hypothetical protein 0.0093 0.0631 0.1386
Echinococcus multilocularis lamin 0.0053 0.0326 0.0535
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.027 0.1176
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0044 0.0252 0.0819
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0309 0.2293 0.3762
Plasmodium vivax lysine--tRNA ligase, putative 0.0069 0.0448 0.0448
Echinococcus granulosus GPCR family 2 0.0047 0.0282 0.0463
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0377 0.1294
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Plasmodium falciparum protein kinase 7 0.0874 0.6629 0.6629
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0603 0.455 1
Schistosoma mansoni transient receptor potential channel 4 0.0289 0.2139 0.3509
Echinococcus granulosus short transient receptor potential channel 6 0.0191 0.1387 0.2276
Brugia malayi SWIRM domain containing protein 0.0025 0.0112 0.0313
Echinococcus multilocularis transient receptor potential gamma protein 0.0289 0.2139 0.3509
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0015 0.0036 0.0054
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.1068 0.2994
Brugia malayi hypothetical protein 0.0025 0.0112 0.0313
Trichomonas vaginalis glucose transporter, putative 0.0096 0.0655 0.2854
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0072 0.0158
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0095 0.0645 0.1418
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0309 0.2293 0.3762
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0161 0.0354
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0645 0.2814
Echinococcus multilocularis musashi 0.0053 0.0326 0.0535
Plasmodium vivax proline--tRNA ligase, putative 0.0108 0.0749 0.0749
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 0.2671 1
Leishmania major threonyl-tRNA synthetase, putative 0.0017 0.0052 0.0689
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0663 0.1857
Echinococcus multilocularis synaptic vesicle 2 protein 0.0044 0.0252 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0655 0.2854
Brugia malayi hypothetical protein 0.0044 0.0252 0.0706
Echinococcus multilocularis glycyl tRNA synthetase 0.0017 0.0052 0.0085
Trichomonas vaginalis sugar transporter, putative 0.0096 0.0655 0.2854
Leishmania major glucose transporter, lmgt1 0.0096 0.0655 0.8744
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0137 0.0383
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0017 0.0052 0.0113
Brugia malayi RNA, U transporter 1 0.0161 0.1152 0.3228
Schistosoma mansoni glucose transport protein 0.0309 0.2293 0.3762
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0161 0.1756
Trichomonas vaginalis myo-inositol transporter, putative 0.0044 0.0252 0.1099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0016 0.0071
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0282 0.0463
Echinococcus multilocularis snurportin 1 0.0603 0.455 0.7464
Loa Loa (eye worm) hypothetical protein 0.0289 0.2139 0.4701
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0025 0.0112 0.0112
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Echinococcus multilocularis solute carrier family 22 0.0044 0.0252 0.0413
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0072 0.0158
Loa Loa (eye worm) major facilitator superfamily transporter 0.0044 0.0252 0.0554
Onchocerca volvulus Putative transporter 0.0044 0.0252 0.3049
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0016 0.0071
Onchocerca volvulus 0.0044 0.0252 0.3049
Brugia malayi glycyl-tRNA synthetase 0.0017 0.0052 0.0145
Loa Loa (eye worm) sugar transporter 0.0044 0.0252 0.0554
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0093 0.0631 0.1767
Echinococcus multilocularis transient receptor potential ion channel A 0.028 0.2065 0.3388
Plasmodium vivax calcium-dependent protein kinase, putative 0.0095 0.0646 0.0646
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0267 0.0438
Schistosoma mansoni lysyl-tRNA synthetase 0.0069 0.0448 0.0735
Echinococcus granulosus lamin 0.0053 0.0326 0.0535
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0038 0.021 0.0463

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 17.6 uM Inhibition of human recombinant MAOB using kynuramine as substrate by fluorescence assay ChEMBL. 22055712
IC50 (binding) = 45.2 uM Inhibition of human recombinant MAOA using kynuramine as substrate by fluorescence assay ChEMBL. 22055712

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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