Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Platelet activating factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.009 | 0.0088 | 0.0086 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0063 | 0.0016 | 0.0014 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.009 | 0.0088 | 0.0086 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0078 | 0.0056 | 0.0054 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0078 | 0.0056 | 0.0054 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0063 | 0.0016 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.019 | 0.0188 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0064 | 0.0019 | 0.0017 |
Echinococcus multilocularis | roundabout 2 | 0.0078 | 0.0056 | 0.0054 |
Mycobacterium tuberculosis | Possible hydrolase MutT1 | 0.0063 | 0.0016 | 0.5 |
Echinococcus multilocularis | serine:threonine protein phosphatase PGAM5 | 0.0063 | 0.0016 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0056 | 0.0054 |
Brugia malayi | UBASH3A protein homolog | 0.0063 | 0.0016 | 0.0039 |
Echinococcus granulosus | c src tyrosine kinase | 0.009 | 0.0088 | 0.0086 |
Brugia malayi | phosphoglycerate mutase family protein | 0.0063 | 0.0016 | 0.0039 |
Onchocerca volvulus | 0.0063 | 0.0016 | 0.0014 | |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0063 | 0.0016 | 0.5 |
Brugia malayi | Variant SH3 domain containing protein | 0.0064 | 0.0019 | 0.0049 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3739 | 1 | 1 |
Brugia malayi | phosphoglycerate mutase family protein | 0.0063 | 0.0016 | 0.0039 |
Toxoplasma gondii | phosphoglycerate mutase | 0.0063 | 0.0016 | 0.5 |
Schistosoma mansoni | phosphoglycerate mutase | 0.0063 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | phosphoglycerate mutase | 0.0063 | 0.0016 | 0.0014 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0111 | 0.0147 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0016 | 0.0014 |
Echinococcus granulosus | roundabout 2 | 0.0078 | 0.0056 | 0.0054 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0064 | 0.0019 | 0.0049 |
Echinococcus granulosus | contactin | 0.0078 | 0.0056 | 0.0054 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase | 0.0078 | 0.0056 | 0.0054 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0064 | 0.0019 | 0.0017 |
Echinococcus granulosus | receptor type tyrosine protein phosphatase | 0.0078 | 0.0056 | 0.0054 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0063 | 0.0016 | 0.0023 |
Schistosoma mansoni | nephrin | 0.0078 | 0.0056 | 0.0056 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0063 | 0.0016 | 0.5 |
Echinococcus multilocularis | receptor type tyrosine protein phosphatase F | 0.0078 | 0.0056 | 0.0054 |
Onchocerca volvulus | Protein UBASH3A homolog | 0.0063 | 0.0016 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0147 | 0.0145 |
Mycobacterium leprae | Possible phosphoglycerate mutase | 0.0063 | 0.0016 | 0.5 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0063 | 0.0016 | 0.0014 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.009 | 0.0088 | 0.0088 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3739 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0063 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0016 | 0.0014 |
Brugia malayi | SRC-1 | 0.009 | 0.0088 | 0.025 |
Treponema pallidum | phosphoglyceromutase | 0.0063 | 0.0016 | 0.5 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0063 | 0.0016 | 0.0023 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2207 | 0.5838 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.009 | 0.0088 | 0.0086 |
Mycobacterium tuberculosis | PE-PGRS family protein PE_PGRS11 | 0.0063 | 0.0016 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.2207 | 0.5838 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.009 | 0.0088 | 0.0086 |
Echinococcus multilocularis | neuroglian | 0.0078 | 0.0056 | 0.0054 |
Echinococcus granulosus | neuroglian | 0.0101 | 0.0119 | 0.0116 |
Echinococcus granulosus | twitchin | 0.0101 | 0.0119 | 0.0116 |
Schistosoma mansoni | neuroglian | 0.0078 | 0.0056 | 0.0056 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.1239 | 0.321 | 0.3209 |
Mycobacterium leprae | POSSIBLE HYDROLASE MUTT1 | 0.0063 | 0.0016 | 0.5 |
Echinococcus granulosus | defective proboscis extension response | 0.008 | 0.0063 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0063 | 0.0061 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0016 | 0.0016 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.009 | 0.0088 | 0.0086 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.009 | 0.0088 | 0.0086 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0063 | 0.0016 | 0.0014 |
Schistosoma mansoni | cell adhesion molecule | 0.0078 | 0.0056 | 0.0056 |
Schistosoma mansoni | receptor tyrosine phosphatase type r2a | 0.0078 | 0.0056 | 0.0056 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0063 | 0.0016 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.3739 | 1 | 1 |
Entamoeba histolytica | phosphoglycerate mutase family protein. putative | 0.0063 | 0.0016 | 0.0023 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0063 | 0.0016 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM) | 0.0063 | 0.0016 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0078 | 0.0056 | 0.0156 |
Schistosoma mansoni | tyrosine kinase | 0.009 | 0.0088 | 0.0088 |
Echinococcus multilocularis | Immunoglobulin | 0.008 | 0.0063 | 0.0061 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0063 | 0.0016 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1595 | 0.4178 | 0.4169 |
Plasmodium falciparum | phosphoglucomutase-2 | 0.0063 | 0.0016 | 0.5 |
Mycobacterium tuberculosis | Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) | 0.0063 | 0.0016 | 0.5 |
Onchocerca volvulus | Protein UBASH3A homolog | 0.0063 | 0.0016 | 0.0014 |
Brugia malayi | hypothetical protein | 0.0111 | 0.0147 | 0.0421 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0016 | 0.0016 |
Onchocerca volvulus | 0.0063 | 0.0016 | 0.0014 | |
Schistosoma mansoni | nephrin | 0.0132 | 0.0203 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0016 | 0.0014 |
Loa Loa (eye worm) | SRC-1 | 0.009 | 0.0088 | 0.0086 |
Mycobacterium tuberculosis | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0063 | 0.0016 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.009 | 0.0088 | 0.0086 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0063 | 0.0016 | 0.0014 |
Echinococcus granulosus | NCK adaptor protein | 0.0064 | 0.0019 | 0.0017 |
Plasmodium vivax | phosphoglycerate mutase, putative | 0.0063 | 0.0016 | 0.5 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0063 | 0.0016 | 0.0014 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0016 | 0.0016 |
Echinococcus multilocularis | serine:threonine protein phosphatase PGAM5 | 0.0063 | 0.0016 | 0.0014 |
Echinococcus multilocularis | roundabout 2 | 0.0078 | 0.0056 | 0.0054 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0016 | 0.0016 |
Mycobacterium ulcerans | hypothetical protein | 0.2207 | 0.5838 | 1 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0064 | 0.0019 | 0.0017 |
Schistosoma mansoni | cell adhesion molecule | 0.0078 | 0.0056 | 0.0056 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.1325 | 0.3444 | 1 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0063 | 0.0016 | 0.0014 |
Schistosoma mansoni | tyrosine kinase | 0.009 | 0.0088 | 0.0088 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0147 | 0.0145 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.009 | 0.0088 | 0.0086 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0063 | 0.0016 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.009 | 0.0088 | 0.0086 |
Mycobacterium leprae | conserved hypothetical protein | 0.0063 | 0.0016 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3676 | 0.9829 | 0.9828 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.009 | 0.0088 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0063 | 0.0061 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0078 | 0.0056 | 0.0054 |
Mycobacterium leprae | probable isochorismate synthase EntC | 0.0063 | 0.0016 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.008 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0016 | 0.0014 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0078 | 0.0056 | 0.0156 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0063 | 0.0016 | 0.0014 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0016 | 0.0016 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3676 | 0.9829 | 0.9828 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3739 | 1 | 1 |
Onchocerca volvulus | 0.3739 | 1 | 1 | |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.3739 | 1 | 1 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0063 | 0.0016 | 0.0014 |
Onchocerca volvulus | Protein UBASH3A homolog | 0.0063 | 0.0016 | 0.0014 |
Trichomonas vaginalis | phosphoglycerate mutase, putative | 0.0063 | 0.0016 | 0.5 |
Onchocerca volvulus | Protein UBASH3A homolog | 0.0063 | 0.0016 | 0.0014 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1595 | 0.4178 | 0.4169 |
Schistosoma mansoni | tyrosine kinase | 0.0072 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0019 | 0.0017 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.009 | 0.0088 | 0.0086 |
Echinococcus granulosus | neuroglian | 0.0078 | 0.0056 | 0.0054 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0063 | 0.0016 | 0.5 |
Echinococcus multilocularis | contactin neuroglian septate junction protein | 0.0078 | 0.0056 | 0.0054 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.008 | 0.0063 | 0.0061 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.0002 | 0.0002 |
Chlamydia trachomatis | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase | 0.0063 | 0.0016 | 0.5 |
Echinococcus multilocularis | phosphoglycerate mutase | 0.0063 | 0.0016 | 0.0014 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.1325 | 0.3444 | 0.3443 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqD | 0.0063 | 0.0016 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.0002 | 0.0002 |
Schistosoma mansoni | cell adhesion molecule | 0.0138 | 0.0218 | 0.0218 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.009 | 0.0088 | 0.0086 |
Echinococcus granulosus | serine:threonine protein phosphatase PGAM5 | 0.0063 | 0.0016 | 0.0014 |
Mycobacterium tuberculosis | Conserved protein | 0.0063 | 0.0016 | 0.5 |
Schistosoma mansoni | phosphoglycerate mutase | 0.0063 | 0.0016 | 0.0016 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0064 | 0.0019 | 0.0019 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1595 | 0.4178 | 0.4169 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0147 | 0.0145 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0064 | 0.0019 | 0.0019 |
Schistosoma mansoni | tyrosine kinase | 0.009 | 0.0088 | 0.0088 |
Brugia malayi | Variant SH3 domain containing protein | 0.0064 | 0.0019 | 0.0049 |
Plasmodium falciparum | phosphoglycerate mutase, putative | 0.0063 | 0.0016 | 0.5 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0063 | 0.0016 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.1595 | 0.4178 | 0.4169 |
Loa Loa (eye worm) | hypothetical protein | 0.0127 | 0.019 | 0.0188 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.009 | 0.0088 | 0.0086 |
Schistosoma mansoni | vesicular amine transporter | 0.008 | 0.0063 | 0.0063 |
Toxoplasma gondii | phosphoglycerate mutase family protein | 0.0063 | 0.0016 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3739 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0158 | 0.0274 | 0.0272 |
Echinococcus granulosus | roundabout 2 | 0.0078 | 0.0056 | 0.0054 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.3676 | 0.9829 | 0.9828 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2207 | 0.5838 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0064 | 0.0019 | 0.0019 |
Echinococcus multilocularis | NCK adaptor protein | 0.0064 | 0.0019 | 0.0017 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.3676 | 0.9829 | 0.9828 |
Giardia lamblia | Hypothetical protein | 0.2207 | 0.5838 | 0.5 |
Mycobacterium leprae | Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase) | 0.0063 | 0.0016 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.009 | 0.0088 | 0.0086 |
Schistosoma mansoni | nck2/grb4 | 0.0064 | 0.0019 | 0.0019 |
Mycobacterium leprae | PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) | 0.0063 | 0.0016 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.009 | 0.0088 | 0.0086 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.009 | 0.0088 | 0.0086 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0111 | 0.0147 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0134 | 0.0132 |
Schistosoma mansoni | adapter molecule crk | 0.0064 | 0.0019 | 0.0019 |
Schistosoma mansoni | tyrosine kinase | 0.009 | 0.0088 | 0.0088 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.3739 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.009 | 0.0088 | 0.0086 |
Echinococcus granulosus | phosphoglycerate mutase | 0.0063 | 0.0016 | 0.0014 |
Mycobacterium tuberculosis | Glucosyl-3-phosphoglycerate phosphatase GpgP | 0.0063 | 0.0016 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3676 | 0.9829 | 0.9829 |
Plasmodium vivax | phosphoglucomutase-2, putative | 0.0063 | 0.0016 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.0101 | 0.0119 | 0.0116 |
Mycobacterium leprae | conserved hypothetical protein | 0.0063 | 0.0016 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0016 | 0.0016 |
Mycobacterium tuberculosis | Conserved protein | 0.0063 | 0.0016 | 0.5 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0078 | 0.0056 | 0.0156 |
Echinococcus granulosus | Immunoglobulin | 0.008 | 0.0063 | 0.0061 |
Onchocerca volvulus | 0.0063 | 0.0016 | 0.0014 | |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0107 | 0.0134 | 0.0132 |
Onchocerca volvulus | 0.1193 | 0.3085 | 0.3083 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0063 | 0.0016 | 0.5 |
Echinococcus granulosus | serine:threonine protein phosphatase PGAM5 | 0.0063 | 0.0016 | 0.0014 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.009 | 0.0088 | 0.0086 |
Toxoplasma gondii | phosphoglycerate mutase PGMII | 0.0063 | 0.0016 | 0.5 |
Echinococcus multilocularis | Immunoglobulin | 0.008 | 0.0063 | 0.0061 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0063 | 0.0016 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.009 | 0.0088 | 0.0086 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.009 | 0.0088 | 0.025 |
Echinococcus multilocularis | c src tyrosine kinase | 0.009 | 0.0088 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.2143 | 0.5667 | 0.5666 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.008 | 0.0063 | 0.0063 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0064 | 0.0019 | 0.0017 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0063 | 0.0016 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.009 | 0.0088 | 0.0086 |
Echinococcus multilocularis | roundabout 2 | 0.0158 | 0.0274 | 0.0272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.