TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 617.776 | Formula: C33H48NO6PS
H donors: 0 H acceptors: 2 LogP: 10.7 Rotable bonds: 21
Rule of 5 violations (Lipinski): 2
SMILES: CCCCCCCCCCCCCCOc1cccc(c1OC)OP(=O)(Oc1cccc(c1)C[n+]1csc(c1C)C)[O-]
InChi: 1S/C33H48NO6PS/c1-5-6-7-8-9-10-11-12-13-14-15-16-23-38-31-21-18-22-32(33(31)37-4)40-41(35,36)39-30-20-17-19-29(24-30)25-34-26-42-28(3)27(34)2/h17-22,24,26H,5-16,23,25H2,1-4H3
InChiKey: SYCMAHBESXHQNI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Cavia porcellus	Platelet activating factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	neuropeptide receptor	Platelet activating factor receptor	342 aa	338 aa	24.9 %
Echinococcus granulosus	neuropeptide receptor	Platelet activating factor receptor	342 aa	304 aa	23.4 %
Onchocerca volvulus		Platelet activating factor receptor	342 aa	295 aa	21.7 %
Onchocerca volvulus		Platelet activating factor receptor	342 aa	327 aa	21.7 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Platelet activating factor receptor	342 aa	340 aa	23.8 %
Echinococcus multilocularis	g-protein coupled receptor	Platelet activating factor receptor	342 aa	351 aa	22.5 %
Echinococcus granulosus	g-protein coupled receptor	Platelet activating factor receptor	342 aa	352 aa	22.2 %
Onchocerca volvulus	Cyclin-dependent kinase 20 homolog	Platelet activating factor receptor	342 aa	383 aa	23.8 %
Echinococcus granulosus	tachykinin peptides receptor 99D	Platelet activating factor receptor	342 aa	314 aa	21.3 %
Onchocerca volvulus		Platelet activating factor receptor	342 aa	300 aa	21.0 %
Echinococcus multilocularis	allatostatin A receptor	Platelet activating factor receptor	342 aa	334 aa	23.4 %
Onchocerca volvulus		Platelet activating factor receptor	342 aa	320 aa	24.7 %
Schistosoma mansoni	opsin-like receptor	Platelet activating factor receptor	342 aa	318 aa	21.7 %
Echinococcus granulosus	rhodopsin orphan GPCR	Platelet activating factor receptor	342 aa	278 aa	16.5 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Platelet activating factor receptor	342 aa	344 aa	25.6 %
Schistosoma mansoni	neuropeptide F-like receptor	Platelet activating factor receptor	342 aa	325 aa	22.2 %
Echinococcus multilocularis	neuropeptide receptor	Platelet activating factor receptor	342 aa	303 aa	23.1 %
Onchocerca volvulus		Platelet activating factor receptor	342 aa	394 aa	20.3 %
Onchocerca volvulus		Platelet activating factor receptor	342 aa	321 aa	19.6 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Platelet activating factor receptor	342 aa	283 aa	20.5 %
Schistosoma mansoni	neuropeptide receptor	Platelet activating factor receptor	342 aa	292 aa	20.5 %
Loa Loa (eye worm)	hypothetical protein	Platelet activating factor receptor	342 aa	355 aa	22.5 %
Onchocerca volvulus		Platelet activating factor receptor	342 aa	342 aa	19.6 %
Echinococcus granulosus	allatostatin A receptor	Platelet activating factor receptor	342 aa	334 aa	22.8 %
Onchocerca volvulus		Platelet activating factor receptor	342 aa	319 aa	21.6 %
Echinococcus multilocularis	rhodopsin orphan GPCR	Platelet activating factor receptor	342 aa	278 aa	16.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	growth factor receptor bound protein 2	0.0064	0.0019	0.0017
Echinococcus granulosus	phosphoglycerate mutase	0.0063	0.0016	0.0014
Schistosoma mansoni	growth factor receptor-bound protein	0.0064	0.0019	0.0019
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0078	0.0056	0.0156
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.008	0.0063	0.0063
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0078	0.0056	0.0054
Mycobacterium tuberculosis	Possible hydrolase MutT1	0.0063	0.0016	0.5
Mycobacterium leprae	conserved hypothetical protein	0.0063	0.0016	0.5
Schistosoma mansoni	cell adhesion molecule	0.0138	0.0218	0.0218
Echinococcus granulosus	contactin	0.0078	0.0056	0.0054
Schistosoma mansoni	phosphoglycerate mutase	0.0063	0.0016	0.0016
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.008	0.0063	0.0063
Schistosoma mansoni	hypothetical protein	0.0063	0.0016	0.0016
Echinococcus multilocularis	Immunoglobulin	0.008	0.0063	0.0061
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.009	0.0088	0.0086
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0063	0.0016	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.009	0.0088	0.0086
Schistosoma mansoni	neuroglian	0.0078	0.0056	0.0056
Chlamydia trachomatis	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase	0.0063	0.0016	0.5
Echinococcus granulosus	twitchin	0.0101	0.0119	0.0116
Loa Loa (eye worm)	phosphoglycerate mutase	0.0063	0.0016	0.0014
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.1325	0.3444	0.3443
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3739	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.009	0.0088	0.0088
Entamoeba histolytica	phosphoglycerate mutase family protein. putative	0.0063	0.0016	0.0023
Mycobacterium tuberculosis	Conserved protein	0.0063	0.0016	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.009	0.0088	0.0086
Brugia malayi	Tyrosine-protein kinase abl-1	0.009	0.0088	0.025
Mycobacterium leprae	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0063	0.0016	0.5
Echinococcus granulosus	neuroglian	0.0078	0.0056	0.0054
Brugia malayi	Variant SH3 domain containing protein	0.0064	0.0019	0.0049
Mycobacterium leprae	conserved hypothetical protein	0.0063	0.0016	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.009	0.0088	0.0086
Schistosoma mansoni	6-phosphofructokinase	0.3739	1	1
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0063	0.0016	0.5
Echinococcus multilocularis	phosphoglycerate mutase	0.0063	0.0016	0.0014
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE)	0.0063	0.0016	0.5
Schistosoma mansoni	tyrosine kinase	0.009	0.0088	0.0088
Trypanosoma brucei	6-phosphofructo-2-kinase 2	0.3676	0.9829	0.9828
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0063	0.0016	0.5
Echinococcus multilocularis	phosphoglycerate mutase	0.0063	0.0016	0.0014
Schistosoma mansoni	nephrin	0.0078	0.0056	0.0056
Brugia malayi	phosphoglycerate mutase family protein	0.0063	0.0016	0.0039
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0063	0.0016	0.5
Schistosoma mansoni	nephrin	0.0132	0.0203	0.0203
Mycobacterium tuberculosis	PE-PGRS family protein PE_PGRS11	0.0063	0.0016	0.5
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0147	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0127	0.019	0.0188
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0063	0.0016	0.0014
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.009	0.0088	0.0086
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.2207	0.5838	1
Brugia malayi	UBASH3A protein homolog	0.0063	0.0016	0.0039
Echinococcus multilocularis	phosphoglycerate mutase	0.0063	0.0016	0.0014
Mycobacterium tuberculosis	Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM)	0.0063	0.0016	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.1239	0.321	0.3209
Echinococcus multilocularis	roundabout 2	0.0078	0.0056	0.0054
Loa Loa (eye worm)	SRC-1	0.009	0.0088	0.0086
Mycobacterium leprae	POSSIBLE HYDROLASE MUTT1	0.0063	0.0016	0.5
Onchocerca volvulus	Protein UBASH3A homolog	0.0063	0.0016	0.0014
Toxoplasma gondii	phosphoglycerate mutase	0.0063	0.0016	0.5
Echinococcus granulosus	phosphoglycerate mutase	0.0063	0.0016	0.0014
Brugia malayi	Sex muscle abnormal protein 5	0.0064	0.0019	0.0049
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0063	0.0016	0.0023
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0078	0.0056	0.0054
Echinococcus granulosus	Immunoglobulin	0.008	0.0063	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0056	0.0054
Echinococcus granulosus	phosphoglycerate mutase	0.0063	0.0016	0.0014
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3676	0.9829	0.9828
Loa Loa (eye worm)	hypothetical protein	0.2143	0.5667	0.5666
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.009	0.0088	0.0086
Brugia malayi	phosphoglycerate mutase family protein	0.0063	0.0016	0.0039
Schistosoma mansoni	tyrosine kinase	0.0072	0.0041	0.0041
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0063	0.0016	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.009	0.0088	0.0086
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.009	0.0088	0.0086
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.3676	0.9829	0.9828
Schistosoma mansoni	hypothetical protein	0.0063	0.0016	0.0016
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0078	0.0056	0.0156
Trypanosoma cruzi	6-phosphofructo-2-kinase 1	0.3676	0.9829	0.9828
Loa Loa (eye worm)	hypothetical protein	0.3676	0.9829	0.9829
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0016	0.0014
Schistosoma mansoni	nck2/grb4	0.0064	0.0019	0.0019
Plasmodium vivax	phosphoglycerate mutase, putative	0.0063	0.0016	0.5
Schistosoma mansoni	adapter molecule crk	0.0064	0.0019	0.0019
Echinococcus granulosus	serine:threonine protein phosphatase PGAM5	0.0063	0.0016	0.0014
Schistosoma mansoni	tyrosine kinase	0.0058	0.0002	0.0002
Echinococcus granulosus	roundabout 2	0.0158	0.0274	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0127	0.019	0.0188
Schistosoma mansoni	tyrosine kinase	0.0058	0.0002	0.0002
Brugia malayi	hypothetical protein	0.0111	0.0147	0.0421
Echinococcus granulosus	roundabout 2	0.0078	0.0056	0.0054
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0078	0.0056	0.0156
Giardia lamblia	Hypothetical protein	0.2207	0.5838	0.5
Treponema pallidum	phosphoglyceromutase	0.0063	0.0016	0.5
Onchocerca volvulus	Protein UBASH3A homolog	0.0063	0.0016	0.0014
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0078	0.0056	0.0054
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0078	0.0056	0.0054
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein	0.1595	0.4178	0.4169
Schistosoma mansoni	phosphoglycerate mutase	0.0063	0.0016	0.0016
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0016	0.5
Echinococcus multilocularis	Immunoglobulin	0.008	0.0063	0.0061
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0063	0.0016	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0063	0.0016	0.5
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0016	0.0014
Echinococcus multilocularis	roundabout 2	0.0158	0.0274	0.0272
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0064	0.0019	0.0017
Mycobacterium ulcerans	hypothetical protein	0.2207	0.5838	1
Schistosoma mansoni	vesicular amine transporter	0.008	0.0063	0.0063
Schistosoma mansoni	cell adhesion molecule	0.0078	0.0056	0.0056
Echinococcus multilocularis	neuroglian	0.0101	0.0119	0.0116
Echinococcus granulosus	phosphoglycerate mutase	0.0063	0.0016	0.0014
Echinococcus granulosus	tyrosine protein kinase Fyn	0.009	0.0088	0.0086
Echinococcus multilocularis	neuroglian	0.0078	0.0056	0.0054
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0064	0.0019	0.0017
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0063	0.0016	0.0014
Schistosoma mansoni	hypothetical protein	0.0063	0.0016	0.0016
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0107	0.0134	0.0132
Schistosoma mansoni	hypothetical protein	0.0063	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0019	0.0017
Trypanosoma brucei	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1595	0.4178	0.4169
Plasmodium falciparum	phosphoglucomutase-2	0.0063	0.0016	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0078	0.0056	0.0054
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0111	0.0147	0.0421
Toxoplasma gondii	phosphoglycerate mutase PGMII	0.0063	0.0016	0.5
Schistosoma mansoni	cell adhesion molecule	0.0078	0.0056	0.0056
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.009	0.0088	0.0086
Leishmania major	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3739	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0064	0.0019	0.0019
Echinococcus multilocularis	NCK adaptor protein	0.0064	0.0019	0.0017
Mycobacterium tuberculosis	Probable conserved lipoprotein LpqD	0.0063	0.0016	0.5
Echinococcus multilocularis	phosphoglycerate mutase	0.0063	0.0016	0.0014
Loa Loa (eye worm)	hypothetical protein	0.008	0.0063	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0016	0.0014
Giardia lamblia	Hypothetical protein	0.2207	0.5838	0.5
Schistosoma mansoni	tyrosine kinase	0.009	0.0088	0.0088
Echinococcus granulosus	tyrosine protein kinase Src64B	0.009	0.0088	0.0086
Brugia malayi	Fibronectin type III domain containing protein	0.0111	0.0147	0.0421
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.009	0.0088	0.0086
Trichomonas vaginalis	phosphoglycerate mutase, putative	0.0063	0.0016	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.009	0.0088	0.0086
Loa Loa (eye worm)	hypothetical protein	0.008	0.0063	0.0061
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3739	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.009	0.0088	0.0086
Schistosoma mansoni	hypothetical protein	0.0063	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.008	0.0063	0.0061
Brugia malayi	Immunoglobulin I-set domain containing protein	0.1325	0.3444	1
Echinococcus granulosus	roundabout 2	0.0078	0.0056	0.0054
Schistosoma mansoni	tyrosine kinase	0.009	0.0088	0.0088
Onchocerca volvulus		0.0063	0.0016	0.0014
Echinococcus granulosus	tyrosine protein kinase Lyn	0.009	0.0088	0.0086
Entamoeba histolytica	phosphoglycerate mutase family protein, putative	0.0063	0.0016	0.0023
Schistosoma mansoni	growth factor receptor-bound protein	0.0064	0.0019	0.0019
Schistosoma mansoni	tyrosine kinase	0.009	0.0088	0.0088
Mycobacterium leprae	conserved hypothetical protein	0.0063	0.0016	0.5
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0147	0.0145
Echinococcus granulosus	phosphoglycerate mutase	0.0063	0.0016	0.0014
Echinococcus granulosus	tyrosine protein kinase Fyn	0.009	0.0088	0.0086
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0064	0.0019	0.0017
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0063	0.0016	0.5
Mycobacterium tuberculosis	Glucosyl-3-phosphoglycerate phosphatase GpgP	0.0063	0.0016	0.5
Loa Loa (eye worm)	hypothetical protein	0.0111	0.0147	0.0145
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.009	0.0088	0.0086
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0078	0.0056	0.0054
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0078	0.0056	0.0056
Onchocerca volvulus		0.3739	1	1
Brugia malayi	SRC-1	0.009	0.0088	0.025
Onchocerca volvulus	Protein UBASH3A homolog	0.0063	0.0016	0.0014
Echinococcus granulosus	c src tyrosine kinase	0.009	0.0088	0.0086
Loa Loa (eye worm)	hypothetical protein	0.3739	1	1
Onchocerca volvulus	Protein UBASH3A homolog	0.0063	0.0016	0.0014
Mycobacterium ulcerans	fructose-2,6-bisphosphatase GpmB	0.2207	0.5838	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0016	0.0014
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0063	0.0016	0.5
Mycobacterium leprae	Possible phosphoglycerate mutase	0.0063	0.0016	0.5
Echinococcus multilocularis	6 phosphofructo 2 kinase:fructose 2	0.3739	1	1
Echinococcus multilocularis	serine:threonine protein phosphatase PGAM5	0.0063	0.0016	0.0014
Echinococcus granulosus	tyrosine protein kinase Fyn	0.009	0.0088	0.0086
Echinococcus multilocularis	phosphoglycerate mutase	0.0063	0.0016	0.0014
Brugia malayi	Variant SH3 domain containing protein	0.0064	0.0019	0.0049
Mycobacterium tuberculosis	Probable phosphoglycerate mutase (phosphoglyceromutase) (phosphoglycerate phosphomutase)	0.0063	0.0016	0.5
Echinococcus granulosus	NCK adaptor protein	0.0064	0.0019	0.0017
Echinococcus multilocularis	phosphoglycerate mutase	0.0063	0.0016	0.0014
Echinococcus multilocularis	c src tyrosine kinase	0.009	0.0088	0.0086
Plasmodium vivax	phosphoglucomutase-2, putative	0.0063	0.0016	0.5
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1595	0.4178	0.4169
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0078	0.0056	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0134	0.0132
Onchocerca volvulus		0.1193	0.3085	0.3083
Plasmodium falciparum	phosphoglycerate mutase, putative	0.0063	0.0016	0.5
Mycobacterium tuberculosis	Conserved protein	0.0063	0.0016	0.5
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.3739	1	1
Onchocerca volvulus		0.0063	0.0016	0.0014
Mycobacterium leprae	PROBABLE PHOSPHOGLYCERATE MUTASE 1 GPM1 (PHOSPHOGLYCEROMUTASE) (PGAM) (BPG-DEPENDENT PGAM)	0.0063	0.0016	0.5
Mycobacterium leprae	probable isochorismate synthase EntC	0.0063	0.0016	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.009	0.0088	0.0086
Echinococcus granulosus	defective proboscis extension response	0.008	0.0063	0.0061
Onchocerca volvulus		0.0063	0.0016	0.0014
Echinococcus granulosus	neuroglian	0.0101	0.0119	0.0116
Toxoplasma gondii	phosphoglycerate mutase family protein	0.0063	0.0016	0.5
Echinococcus multilocularis	roundabout 2	0.0078	0.0056	0.0054
Trypanosoma cruzi	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative	0.1595	0.4178	0.4169
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.009	0.0088	0.0086
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.008	0.0063	0.0061
Schistosoma mansoni	hypothetical protein	0.0063	0.0016	0.0016

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 9.5 uM	Inhibition of PAF induced platelet aggregation in rabbit	ChEMBL.	1578493
IC50 (functional)	= 9.5 uM	Inhibition of PAF induced platelet aggregation in rabbit	ChEMBL.	1578493

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 65068