TDR Targets

Basic information

Technical information

TDR Targets ID: 65319
Name: N-tert-butyl-N'-[3-methoxy-4-(1H-pyrrol-2-yl) phenyl]oxamide
MW: 315.367 | Formula: C17H21N3O3
H donors: 3 H acceptors: 2 LogP: 2.21 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1c1ccc[nH]1)NC(=O)C(=O)NC(C)(C)C
InChi: 1S/C17H21N3O3/c1-17(2,3)20-16(22)15(21)19-11-7-8-12(14(10-11)23-4)13-6-5-9-18-13/h5-10,18H,1-4H3,(H,19,21)(H,20,22)
InChiKey: HRETWRBJDBHITJ-UHFFFAOYSA-N

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-tert-butyl-N'-[3-methoxy-4-(1H-pyrrol-2-yl)phenyl]ethanediamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	IMP (inosine 5'-monophosphate) dehydrogenase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	guanosine nucleotide biosynthesis	Get druggable targets OG5_126887	All targets in OG5_126887
Cryptosporidium parvum	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	guanosine nucleotide biosynthesis	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	N terminus of Inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei gambiense	inosine-5-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania donovani	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania mexicana	guanosine monophosphate reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania infantum	guanosine monophosphate reductase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Schistosoma japonicum	ko:K00088 IMP dehydrogenase [EC1.1.1.205], putative	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania braziliensis	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Babesia bovis	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Loa Loa (eye worm)	IMP dehydrogenase 1	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Cryptosporidium hominis	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	Get druggable targets OG5_126887	All targets in OG5_126887
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium berghei	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania donovani	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Theileria parva	Inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium yoelii	inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	Get druggable targets OG5_126887	All targets in OG5_126887
Plasmodium knowlesi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Neospora caninum	hypothetical protein	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma brucei gambiense	inosine-5-monophosphate dehydrogenase,IMP dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Candida albicans	N terminus of Inosine-5'-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Toxoplasma gondii	IMP dehydrogenas	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania braziliensis	guanosine monophosphate reductase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma congolense	GMP reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania major	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania major	guanosine monophosphate reductase	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania infantum	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	Get druggable targets OG5_126887	All targets in OG5_126887
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	Get druggable targets OG5_126887	All targets in OG5_126887
Leishmania mexicana	inosine-5-monophosphate dehydrogenase	Get druggable targets OG5_126887	All targets in OG5_126887

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Peroxidasin	0.0027	0.0824	0.0918
Brugia malayi	hypothetical protein	0.0025	0.074	0.0822
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.074	0.1566
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0558	0.0732
Toxoplasma gondii	IMP dehydrogenas	0.0095	0.3831	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.097	0.1273
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1734	0.2275
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0558	0.0732
Brugia malayi	hypothetical protein	0.001	0.0073	0.0058
Loa Loa (eye worm)	IMP dehydrogenase 1	0.0095	0.3831	0.4365
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0558	0.0732
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0009	0.0023	0.003
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.002	0.0525	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0558	0.0613
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0558	0.0613
Brugia malayi	steroid hormone receptor	0.0021	0.0558	0.0613
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.097	0.1273
Trichomonas vaginalis	set domain proteins, putative	0.0234	1	1
Brugia malayi	glutathione reductase	0.0037	0.1291	0.1453
Schistosoma mansoni	notch	0.0009	0.0023	0.003
Brugia malayi	Pre-SET motif family protein	0.0206	0.8746	1
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0073	0.0058
Schistosoma mansoni	cell polarity protein	0.0009	0.0023	0.003
Onchocerca volvulus		0.0027	0.0824	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0125	0.0117
Onchocerca volvulus	Peroxidase homolog	0.0027	0.0824	0.0803
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.074	0.1459
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0058
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0073	0.0096
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.002	0.0529	0.0323
Schistosoma mansoni	hypothetical protein	0.0009	0.0023	0.003
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.074	0.1566
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0558	0.0613
Trichomonas vaginalis	MYB, putative	0.002	0.0529	0.0323
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0558	0.0732
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0134	0.0176
Echinococcus granulosus	neurogenic locus notch protein	0.0009	0.0023	0.003
Schistosoma mansoni	notch	0.0009	0.0023	0.003
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.097	0.2488
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0558	0.0613
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0558	0.0613
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.1734	0.2275
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.0095	0.3831	1
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0095	0.3831	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0824	0.0918
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0038	0.1313	0.1722
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0125	0.0117
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0558	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0824	0.0918
Echinococcus granulosus	slit 2 protein	0.0009	0.0023	0.003
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0085	0.3405	0.8823
Onchocerca volvulus	Bile acid receptor homolog	0.0021	0.0558	0.0536
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0558	0.0613
Brugia malayi	hypothetical protein	0.0027	0.0824	0.0918
Onchocerca volvulus		0.0027	0.0824	0.0803
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0073	0.0096
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0558	0.0732
Brugia malayi	hypothetical protein	0.0011	0.0125	0.0117
Echinococcus multilocularis	neurogenic locus protein delta	0.0009	0.0023	0.003
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0558	0.0613
Mycobacterium tuberculosis	Probable oxidoreductase	0.0095	0.3825	0.9983
Schistosoma mansoni	nuclear receptor nhr-48	0.001	0.0073	0.0096
Echinococcus multilocularis	nuclear receptor nhr 48	0.001	0.0073	0.0096
Schistosoma mansoni	notch	0.0009	0.0023	0.003
Brugia malayi	conserved hypotetical protein	0.001	0.0073	0.0058
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0013	0.0213	0.0217
Brugia malayi	Thioredoxin reductase	0.0037	0.1291	0.1453
Echinococcus multilocularis	protein jagged 1	0.0009	0.0023	0.003
Onchocerca volvulus		0.0028	0.0894	0.0872
Trichomonas vaginalis	C-MYB, putative	0.002	0.0525	0.0319
Toxoplasma gondii	Myb family DNA-binding domain-containing protein	0.002	0.0529	0.1328
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0037	0.1291	0.298
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0824	0.0918
Loa Loa (eye worm)	animal heme peroxidase	0.0027	0.0824	0.0918
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0073	0.0096
Echinococcus multilocularis	slit 2 protein	0.0009	0.0023	0.003
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0558	0.0732
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0558	0.0732
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.001	0.0073	0.0096
Onchocerca volvulus	Putative GMP reductase	0.0039	0.1382	0.1362
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0824	0.0918
Trypanosoma cruzi	trypanothione reductase, putative	0.0037	0.1291	0.298
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0085	0.3405	0.8823
Leishmania major	trypanothione reductase	0.0037	0.1291	0.298
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0894	0.0998
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0085	0.3405	0.8823
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.0089	0.3582	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0558	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0125	0.0117
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.1734	0.2275
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0558	0.0732
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.097	0.1273
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.002	0.0525	0.5
Onchocerca volvulus		0.0027	0.0824	0.0803
Echinococcus granulosus	protein jagged 2	0.0009	0.0023	0.003
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0125	0.0164
Schistosoma mansoni	nuclear receptor	0.001	0.0073	0.0096
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0039	0.1382	0.1558
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.0095	0.3831	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0558	0.0732
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.002	0.0525	0.0319
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0558	0.0732
Toxoplasma gondii	thioredoxin reductase	0.0037	0.1291	0.333
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.002	0.0525	0.0319
Trypanosoma brucei	trypanothione reductase	0.0037	0.1291	0.298
Schistosoma mansoni	hypothetical protein	0.0009	0.0023	0.003
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0558	0.0613
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.005	0.1841	0.45
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.074	0.1459
Leishmania major	inosine-5-monophosphate dehydrogenase	0.0095	0.3831	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0558	0.0613
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.097	0.1273
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0076	0.01
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0009	0.0061	0.0043
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0073	0.0058
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1734	0.2275
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.001	0.0073	0.005
Echinococcus granulosus	notch	0.0009	0.0023	0.003
Echinococcus granulosus	geminin	0.0181	0.7624	1
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.1291	0.32
Echinococcus multilocularis	peroxidasin	0.0027	0.0824	0.1081
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0076	0.0061
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.002	0.0525	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0824	0.0918
Brugia malayi	nuclear hormone receptor family member nhr-6	0.001	0.0073	0.0058
Brugia malayi	nuclear hormone receptor family member odr-7	0.001	0.0073	0.0058
Toxoplasma gondii	NADPH-glutathione reductase	0.0013	0.0213	0.0498
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.074	0.1566
Echinococcus granulosus	protein jagged 1	0.0009	0.0023	0.003
Brugia malayi	GMP reductase	0.0039	0.1382	0.1558
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0095	0.3825	0.9983
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.1734	0.1962
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0824	0.0918
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.074	0.1459
Schistosoma mansoni	hypothetical protein	0.0181	0.7624	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0558	0.0613
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.002	0.0525	0.5
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.001	0.0073	0.0096
Brugia malayi	Blistered cuticle protein 3	0.0027	0.0824	0.0918
Loa Loa (eye worm)	hypothetical protein	0.0161	0.676	0.7723
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0895	0.1174
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0058
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0558	0.0732
Schistosoma mansoni	nuclear receptor	0.001	0.0073	0.0096
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.001	0.0073	0.0096
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0009	0.0023	0.000000054664
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.002	0.0525	0.0319
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.1734	0.2275
Onchocerca volvulus		0.0161	0.676	0.6752
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0558	0.0613
Trichomonas vaginalis	C-MYB, putative	0.002	0.0525	0.0319
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0009	0.0023	0.003
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0558	0.0613
Echinococcus granulosus	thyroid hormone receptor alpha	0.001	0.0073	0.0096
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.002	0.0529	0.0323
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0558	0.0613
Loa Loa (eye worm)	animal heme peroxidase	0.0027	0.0824	0.0918
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.001	0.0073	0.0058
Treponema pallidum	NADH oxidase	0.0013	0.0213	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0558	0.0732
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0095	0.3831	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0558	0.0732
Schistosoma mansoni	hypothetical protein	0.0009	0.0023	0.003
Loa Loa (eye worm)	GMP reductase	0.0039	0.1382	0.1558
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0824	0.0918
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0558	0.0732
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.0095	0.3831	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0058
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.0095	0.3831	0.5024
Brugia malayi	hypothetical protein	0.0161	0.676	0.7723
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0011	0.0125	0.0164
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.097	0.1273
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.002	0.0525	0.5
Brugia malayi	nuclear hormone receptor	0.0021	0.0558	0.0613
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0011	0.0125	0.0164
Echinococcus multilocularis	cpg binding protein	0.003	0.0965	0.1266
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0009	0.0061	0.0043
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0045	0.1631	0.392
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.2062	0.5355
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0558	0.0613
Schistosoma mansoni	peroxidasin	0.0027	0.0824	0.1081
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0558	0.0613
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.005	0.1841	0.0954
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0125	0.0117
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0558	0.0613
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.4838	0.552
Plasmodium vivax	SET domain protein, putative	0.003	0.097	0.2249
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0095	0.3825	0.9983
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.097	0.1273
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0558	0.0732
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0076	0.01
Plasmodium vivax	glutathione reductase, putative	0.0037	0.1291	0.32
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.002	0.0525	0.5
Trichomonas vaginalis	MYB72, putative	0.002	0.0525	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0558	0.0613
Schistosoma mansoni	slit	0.0009	0.0023	0.003
Loa Loa (eye worm)	nuclear hormone receptor	0.001	0.0073	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0824	0.0918
Brugia malayi	ecdysone receptor	0.001	0.0073	0.0058
Trichomonas vaginalis	pc-MYB2, putative	0.002	0.0525	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0824	0.0918
Onchocerca volvulus	Dual oxidase homolog	0.0027	0.0824	0.0803
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0058
Echinococcus multilocularis	neurogenic locus notch protein	0.0009	0.0023	0.003
Plasmodium falciparum	glutathione reductase	0.0037	0.1291	0.32
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0558	0.0732
Brugia malayi	nuclear hormone receptor	0.001	0.0073	0.0058
Echinococcus granulosus	cpg binding protein	0.003	0.0965	0.1266
Brugia malayi	hypothetical protein	0.0011	0.0125	0.0117
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0073	0.0096
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0085	0.3405	0.8064
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0021	0.0558	0.0732
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0039	0.1382	0.1558
Brugia malayi	ecdysteroid receptor	0.0021	0.0558	0.0613
Onchocerca volvulus		0.003	0.097	0.0949
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0021	0.0558	0.0536
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0058
Echinococcus granulosus	peroxidasin	0.0027	0.0824	0.1081
Echinococcus granulosus	nuclear receptor nhr 48	0.001	0.0073	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0824	0.0918
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0073	0.0096
Schistosoma mansoni	cpg binding protein	0.003	0.0965	0.1266
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0013	0.0213	0.3749
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0558	0.0613
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0558	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0125	0.0117
Echinococcus granulosus	neurogenic locus notch protein	0.0009	0.0023	0.003
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0089	0.3582	0.9312
Brugia malayi	tailless protein	0.001	0.0073	0.0058
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0558	0.0613
Trypanosoma cruzi	GMP reductase	0.0095	0.3831	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0824	0.0918
Echinococcus multilocularis	notch	0.0009	0.0023	0.003
Schistosoma mansoni	coup transcription factor	0.0021	0.0558	0.0732
Trichomonas vaginalis	MYB3r3, putative	0.002	0.0525	0.0319
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.001	0.0073	0.005
Loa Loa (eye worm)	hypothetical protein	0.0025	0.074	0.0822
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0558	0.0732
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.0095	0.3831	0.5024
Onchocerca volvulus		0.0021	0.0558	0.0536
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0013	0.0213	0.0279
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0824	0.0918
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.8746	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.001	0.0073	0.0058
Schistosoma mansoni	hypothetical protein	0.0181	0.7624	1
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.0089	0.3582	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0085	0.3405	0.8823
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0011	0.0125	0.0117
Trypanosoma cruzi	GMP reductase	0.0095	0.3831	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.097	0.1273
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.001	0.0073	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0558	0.0613
Schistosoma mansoni	peroxidasin	0.0027	0.0824	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0824	0.0918
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0095	0.3831	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0058
Brugia malayi	nuclear receptor NHR-67	0.001	0.0073	0.0058
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0558	0.0732
Loa Loa (eye worm)	animal heme peroxidase	0.0027	0.0824	0.0918
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.0095	0.3831	1
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0558	0.0613
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.1734	0.2275
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0013	0.0213	0.0279
Brugia malayi	EGF-like domain containing protein	0.0009	0.0023	0.000000062523
Echinococcus multilocularis	neurogenic locus notch protein	0.0009	0.0023	0.003
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0558	0.0613
Schistosoma mansoni	laminin gamma-3 chain	0.0009	0.0023	0.003
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0558	0.0613
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0558	0.0732
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0073	0.0096
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0125	0.0117
Loa Loa (eye worm)	hypothetical protein	0.003	0.097	0.1086
Leishmania major	guanosine monophosphate reductase	0.0095	0.3831	1
Plasmodium falciparum	thioredoxin reductase	0.0037	0.1291	0.32
Brugia malayi	nuclear receptor RXR	0.001	0.0073	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0558	0.0613
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.002	0.0525	0.0319
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1734	0.2275
Echinococcus granulosus	protein jagged 1	0.0009	0.0023	0.003
Echinococcus granulosus	protein jagged 2	0.0009	0.0023	0.003
Brugia malayi	hypothetical protein	0.001	0.0073	0.0058
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0558	0.0732
Trypanosoma brucei	GMP reductase	0.0095	0.3831	1
Loa Loa (eye worm)	blistered cuticle protein 3	0.0027	0.0824	0.0918
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0058
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.0095	0.3831	0.5024
Trichomonas vaginalis	pc-MYB2, putative	0.002	0.0525	0.0319
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0009	0.0023	0.003
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0073	0.0096
Giardia lamblia	Myb 1-like protein	0.002	0.0529	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0558	0.0732
Onchocerca volvulus	Chorion peroxidase homolog	0.0027	0.0824	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0558	0.0613
Schistosoma mansoni	cpg binding protein	0.0028	0.0894	0.1172
Echinococcus granulosus	neural cadherin	0.0009	0.0023	0.003
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0073	0.0096
Onchocerca volvulus	Neurogenic locus notch homolog	0.0009	0.0023	0.000000054664
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0824	0.0918
Loa Loa (eye worm)	glutathione reductase	0.0037	0.1291	0.1453
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0558	0.0732
Brugia malayi	orphan nuclear receptor NR2E1	0.001	0.0073	0.0058
Schistosoma mansoni	hypothetical protein	0.0009	0.0023	0.003
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0824	0.0918
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0058
Onchocerca volvulus	Peroxidasin homolog	0.0027	0.0824	0.0803
Mycobacterium tuberculosis	Probable dehydrogenase	0.0085	0.3405	0.8823
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0013	0.0213	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.2346	0.3077
Loa Loa (eye worm)	DR-78	0.001	0.0073	0.0058
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.001	0.0073	0.0096
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0071	0.0055
Onchocerca volvulus		0.001	0.0073	0.005
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0558	0.0732
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0558	0.0732
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0134	0.0176
Schistosoma mansoni	hypothetical protein	0.0011	0.0134	0.0176
Schistosoma mansoni	zinc finger protein	0.001	0.0073	0.0096
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0558	0.0613
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0013	0.0213	0.0279
Echinococcus multilocularis	protein jagged 1	0.0009	0.0023	0.003
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0058
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0013	0.0213	0.0498
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.0095	0.3831	0.4365
Echinococcus multilocularis	fibropellin Ia	0.0009	0.0023	0.003
Echinococcus multilocularis	geminin	0.0181	0.7624	1
Echinococcus granulosus	neurogenic locus protein delta	0.0009	0.0023	0.003
Schistosoma mansoni	hypothetical protein	0.0009	0.0023	0.003
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0058
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0558	0.0613
Brugia malayi	nuclear receptor NHR-88	0.001	0.0073	0.0058
Schistosoma mansoni	septate junction protein	0.0009	0.0023	0.003
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0894	0.0998
Schistosoma mansoni	cpg binding protein	0.003	0.0965	0.1266
Schistosoma mansoni	notch	0.0009	0.0023	0.003
Brugia malayi	MH2 domain containing protein	0.0118	0.4838	0.552
Brugia malayi	hypothetical protein	0.0016	0.0351	0.0375
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.0095	0.3831	1
Brugia malayi	nuclear receptor RXR	0.0011	0.0125	0.0117
Onchocerca volvulus	Peroxidasin homolog	0.0027	0.0824	0.0803
Mycobacterium tuberculosis	Probable reductase	0.0085	0.3405	0.8823
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0824	0.0918
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.1734	0.1962
Echinococcus granulosus	fibropellin Ia	0.0009	0.0023	0.003
Brugia malayi	notch-like transmembrane receptor	0.0009	0.0023	0.000000062523
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0058
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0095	0.3825	0.9973
Onchocerca volvulus		0.001	0.0073	0.005
Leishmania major	hypothetical protein, conserved	0.0025	0.074	0.1459
Echinococcus multilocularis	protein jagged 2	0.0009	0.0023	0.003
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0011	0.0125	0.0164
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0558	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0023	0.000000062523
Onchocerca volvulus	Peroxidase homolog	0.0027	0.0824	0.0803
Schistosoma mansoni	hypothetical protein	0.0009	0.0023	0.003
Schistosoma mansoni	notch	0.0009	0.0023	0.003
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.074	0.1884
Brugia malayi	Pre-SET motif family protein	0.003	0.097	0.1086
Echinococcus granulosus	delta-like protein 1	0.0009	0.0023	0.003
Schistosoma mansoni	hypothetical protein	0.0009	0.0023	0.003
Echinococcus granulosus	neurogenic locus notch protein 4	0.0009	0.0023	0.003
Echinococcus granulosus	thioredoxin glutathione reductase	0.0038	0.1313	0.1722
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0558	0.0732
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.001	0.0073	0.0096
Onchocerca volvulus	Protein ultraspiracle homolog	0.0021	0.0558	0.0536
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0558	0.0732
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0058
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0558	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0824	0.0918
Echinococcus multilocularis	neurogenic locus protein delta	0.0009	0.0023	0.003
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0558	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0558	0.0613
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0558	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0125	0.0117
Echinococcus multilocularis	neural cadherin	0.0009	0.0023	0.003
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0558	0.0732
Loa Loa (eye worm)	hypothetical protein	0.001	0.0073	0.0058
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0824	0.0918
Schistosoma mansoni	notch	0.0009	0.0023	0.003
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.4838	0.552
Loa Loa (eye worm)	animal heme peroxidase	0.0027	0.0824	0.0918
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.1291	0.1453
Brugia malayi	Animal haem peroxidase family protein	0.0027	0.0824	0.0918
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.002	0.0525	0.0319

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.4 uM	Inhibitory activity of the compound against (IMPDH) inosine 5'-monophosphate dehydrogenase	ChEMBL.	12729643
IC50 (binding)	= 2.4 uM	Inhibitory activity of the compound against (IMPDH) inosine 5'-monophosphate dehydrogenase	ChEMBL.	12729643

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 20766837

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 65319