TDR Targets

Basic information

Technical information

TDR Targets ID: 664694
Name: 4-chloro-2-[[2-(4-nitrophenyl)acetyl]amino]be nzoic acid
MW: 334.711 | Formula: C15H11ClN2O5
H donors: 2 H acceptors: 5 LogP: 3.23 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cc(Cl)ccc1C(=O)O)Cc1ccc(cc1)[N+](=O)[O-]
InChi: 1S/C15H11ClN2O5/c16-10-3-6-12(15(20)21)13(8-10)17-14(19)7-9-1-4-11(5-2-9)18(22)23/h1-6,8H,7H2,(H,17,19)(H,20,21)
InChiKey: ZKZGSFORLVERPM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-chloro-2-[[2-(4-nitrophenyl)-1-oxoethyl]amino]benzoic acid
4-chloro-2-[2-(4-nitrophenyl)ethanoylamino]benzoic acid
STK223994

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	tubulin gamma chain, putative	0.0057	0.1104	0.1104
Plasmodium falciparum	tubulin gamma chain	0.0057	0.1104	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0158	0.0252
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Echinococcus multilocularis	hypothetical protein	0.0057	0.1104	0.1758
Plasmodium vivax	tubulin alpha chain, putative	0.0057	0.1104	1
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Brugia malayi	hypoxia-induced factor 1	0.0152	0.4308	0.686
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.1104	0.1104
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0058	0.1117	0.9068
Plasmodium falciparum	tubulin beta chain	0.0057	0.1104	1
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0058	0.1117	0.1779
Leishmania major	alpha tubulin	0.0057	0.1104	0.8959
Schistosoma mansoni	tubulin subunit alpha	0.0057	0.1104	0.1758
Echinococcus granulosus	alpha tubulin	0.0057	0.1104	0.1758
Loa Loa (eye worm)	carboxylesterase	0.0035	0.0357	0.0569
Echinococcus granulosus	Tubulin beta 2C chain	0.0057	0.1104	0.1758
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0035	0.0357	0.0803
Trypanosoma brucei	beta tubulin	0.0057	0.1104	1
Trypanosoma cruzi	tubulin gamma chain	0.0057	0.1104	1
Plasmodium vivax	SET domain protein, putative	0.003	0.0158	0.1435
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.1232	1
Loa Loa (eye worm)	acetylcholinesterase 1	0.0209	0.628	1
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Plasmodium falciparum	tubulin epsilon chain, putative	0.0057	0.1104	1
Brugia malayi	Tubulin gamma chain	0.0057	0.1104	0.1758
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Giardia lamblia	Beta tubulin	0.0057	0.1104	0.1104
Trypanosoma cruzi	epsilon tubulin, putative	0.0057	0.1104	1
Echinococcus granulosus	tubulin beta 1 chain	0.0057	0.1104	0.1758
Echinococcus granulosus	acetylcholinesterase	0.0209	0.628	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.1104	0.1104
Echinococcus granulosus	beta tubulin	0.0057	0.1104	0.1758
Toxoplasma gondii	beta-tubulin, putative	0.0057	0.1104	0.8959
Schistosoma mansoni	tubulin subunit alpha	0.0057	0.1104	0.1758
Echinococcus multilocularis	tubulin alpha chain	0.0057	0.1104	0.1758
Trypanosoma brucei	alpha tubulin	0.0057	0.1104	1
Schistosoma mansoni	alpha-glucosidase	0.0153	0.4358	0.6938
Brugia malayi	Tubulin alpha-2 chain	0.0057	0.1104	0.1758
Brugia malayi	bHLH-PAS transcription factor	0.0036	0.0386	0.0614
Echinococcus granulosus	Tubulin beta 2C chain	0.0057	0.1104	0.1758
Trypanosoma brucei	alpha tubulin	0.0057	0.1104	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0039	0.0495	0.0788
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0035	0.0357	0.0569
Brugia malayi	Carboxylesterase family protein	0.0209	0.628	1
Echinococcus granulosus	tubulin gamma 1 chain	0.0057	0.1104	0.1758
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0156	0.4452	1
Echinococcus multilocularis	tubulin alpha chain	0.0057	0.1104	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0357	0.0569
Onchocerca volvulus		0.0103	0.265	0.3574
Echinococcus granulosus	tubulin alpha 3 chain	0.0057	0.1104	0.1758
Loa Loa (eye worm)	alpha-tubulin	0.0057	0.1104	0.1758
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	1	1
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0058	0.1117	0.1779
Echinococcus multilocularis	tubulin alpha chain	0.0057	0.1104	0.1758
Trypanosoma cruzi	epsilon tubulin, putative	0.0057	0.1104	1
Trypanosoma brucei	epsilon tubulin	0.0057	0.1104	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0057	0.1104	0.1758
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0158	0.0252
Trichomonas vaginalis	protein phosphatase 2C, putative	0.0117	0.3136	0.3136
Trypanosoma brucei	tubulin gamma chain	0.0057	0.1104	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0057	0.1104	0.1758
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0495	0.4482
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Entamoeba histolytica	tubulin family protein	0.0057	0.1104	0.0641
Schistosoma mansoni	tubulin subunit beta	0.0057	0.1104	0.1758
Echinococcus granulosus	carboxylesterase 5A	0.0209	0.628	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0057	0.1104	0.1758
Echinococcus granulosus	tubulin alpha chain	0.0057	0.1104	0.1758
Trichomonas vaginalis	tubulin alpha chain, putative	0.0057	0.1104	0.1104
Echinococcus multilocularis	tubulin epsilon chain	0.0057	0.1104	0.1758
Leishmania major	alpha tubulin	0.0057	0.1104	0.8959
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Brugia malayi	tubulin alpha chain - mouse	0.0057	0.1104	0.1758
Brugia malayi	hypothetical protein	0.0035	0.0357	0.0569
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0057	0.1104	0.1758
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Trichomonas vaginalis	tubulin, putative	0.0032	0.0257	0.0257
Echinococcus granulosus	neutral alpha glucosidase AB	0.0039	0.0495	0.0788
Echinococcus granulosus	tubulin subunit beta	0.0057	0.1104	0.1758
Brugia malayi	tubulin alpha-2 chain	0.0057	0.1104	0.1758
Echinococcus granulosus	BC026374 protein S09 family	0.0035	0.0357	0.0569
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0039	0.0495	0.0788
Echinococcus granulosus	Tubulin beta 2C chain	0.0057	0.1104	0.1758
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0152	0.4308	0.686
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	1	1
Brugia malayi	Carboxylesterase family protein	0.0035	0.0357	0.0569
Echinococcus granulosus	beta tubulin	0.0057	0.1104	0.1758
Echinococcus granulosus	Tubulin beta 2C chain	0.0057	0.1104	0.1758
Schistosoma mansoni	tubulin subunit beta	0.0057	0.1104	0.1758
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0056	0.1043	0.1661
Echinococcus multilocularis	beta tubulin	0.0057	0.1104	0.1758
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0035	0.0357	0.0803
Brugia malayi	Pre-SET motif family protein	0.0206	0.6162	0.9812
Brugia malayi	Carboxylesterase family protein	0.0035	0.0357	0.0569
Echinococcus granulosus	tubulin alpha 1C chain	0.0057	0.1104	0.1758
Trypanosoma brucei	epsilon tubulin	0.0057	0.1104	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0495	0.0495
Echinococcus granulosus	tubulin alpha	0.0057	0.1104	0.1758
Trichomonas vaginalis	tubulin alpha chain, putative	0.0032	0.0257	0.0257
Echinococcus granulosus	tubulin alpha chain	0.0057	0.1104	0.1758
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0035	0.0357	0.0569
Schistosoma mansoni	tubulin subunit beta	0.0057	0.1104	0.1758
Onchocerca volvulus		0.0035	0.0357	0.0285
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0054	0.0985	0.1568
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0064	0.1336	0.2127
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0495	0.0495
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0156	0.4452	1
Trypanosoma brucei	glucosidase, putative	0.0039	0.0495	0.4482
Schistosoma mansoni	alpha glucosidase	0.0039	0.0495	0.0788
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.1232	0.2768
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0495	0.0495
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0158	0.0252
Trichomonas vaginalis	tubulin, putative	0.0032	0.0257	0.0257
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0178	0.52	0.8279
Leishmania major	gamma-tubulin	0.0057	0.1104	0.8959
Treponema pallidum	fructose-bisphosphate aldolase	0.0319	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0057	0.1104	0.1758
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.1104	0.1104
Echinococcus granulosus	tubulin epsilon chain	0.0057	0.1104	0.1758
Echinococcus multilocularis	tubulin beta 1 chain	0.0057	0.1104	0.1758
Echinococcus granulosus	tubulin alpha 1C chain	0.0057	0.1104	0.1758
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0178	0.52	0.8279
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	1	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0035	0.0357	0.0569
Trichomonas vaginalis	protein phosphatase 2C delta isoform, putative	0.0117	0.3136	0.3136
Mycobacterium ulcerans	carboxylesterase, LipT	0.0035	0.0357	0.0803
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.1232	0.2768
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Echinococcus granulosus	tubulin alpha chain	0.0057	0.1104	0.1758
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.1232	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0357	0.0569
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0058	0.1117	0.1779
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0495	0.0495
Trichomonas vaginalis	alpha-glucosidase, putative	0.0039	0.0495	0.0495
Schistosoma mansoni	tubulin subunit beta	0.0057	0.1104	0.1758
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0025	0	0.5
Echinococcus granulosus	lysine specific demethylase 5A	0.0064	0.1336	0.2127
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0058	0.1117	0.251
Leishmania major	alpha tubulin	0.0057	0.1104	0.8959
Trypanosoma brucei	alpha tubulin	0.0057	0.1104	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0057	0.1104	0.1758
Echinococcus granulosus	tubulin beta 4A class IVa	0.0057	0.1104	0.1758
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	1	1
Onchocerca volvulus		0.0032	0.0257	0.0141
Schistosoma mansoni	acetylcholinesterase	0.0035	0.0357	0.0569
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0057	0.1104	0.8959
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.0495	0.0495
Echinococcus granulosus	tubulin subunit TubB	0.0057	0.1104	0.1758
Plasmodium vivax	tubulin alpha chain, putative	0.0057	0.1104	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0032	0.0257	0.0257
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0209	0.628	1
Leishmania major	epsilon tubulin, putative	0.0057	0.1104	0.8959
Echinococcus multilocularis	transfer RNA-Lys	0.0036	0.0386	0.0614
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Trypanosoma cruzi	alpha tubulin, putative	0.0057	0.1104	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0064	0.1336	0.2127
Brugia malayi	jmjC domain containing protein	0.0064	0.1336	0.2127
Echinococcus multilocularis	tubulin alpha 3 chain	0.0057	0.1104	0.1758
Echinococcus granulosus	tubulin alpha 3 chain	0.0057	0.1104	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0209	0.628	1
Entamoeba histolytica	tubulin gamma chain	0.0057	0.1104	0.0641
Trichomonas vaginalis	protein phosphatase type 2C, putative	0.0117	0.3136	0.3136
Trypanosoma brucei	alpha tubulin	0.0057	0.1104	1
Echinococcus multilocularis	acetylcholinesterase	0.0209	0.628	1
Onchocerca volvulus		0.0035	0.0357	0.0285
Echinococcus multilocularis	tubulin subunit beta	0.0057	0.1104	0.1758
Entamoeba histolytica	tubulin family protein	0.0057	0.1104	0.0641
Echinococcus multilocularis	tubulin gamma 1 chain	0.0057	0.1104	0.1758
Echinococcus multilocularis	beta tubulin	0.0057	0.1104	0.1758
Trypanosoma brucei	alpha tubulin, putative	0.0032	0.0257	0.2326
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0121	0.0193
Loa Loa (eye worm)	tubulin gamma chain	0.0057	0.1104	0.1758
Schistosoma mansoni	BC026374 protein (S09 family)	0.0035	0.0357	0.0569
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0039	0.0495	0.0788
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.1232	0.1962
Trichomonas vaginalis	tubulin gamma chain, putative	0.0057	0.1104	0.1104
Trypanosoma brucei	beta tubulin	0.0057	0.1104	1
Schistosoma mansoni	tubulin subunit epsilon	0.0057	0.1104	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0209	0.628	1
Loa Loa (eye worm)	tubulin alpha chain	0.0057	0.1104	0.1758
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0058	0.1117	0.1779
Plasmodium falciparum	alpha tubulin 2	0.0057	0.1104	1
Schistosoma mansoni	aryl hydrocarbon receptor	0.0049	0.0819	0.1304
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.6162	0.9812
Leishmania major	alpha glucosidase II subunit, putative	0.0039	0.0495	0.4015
Echinococcus multilocularis	acetylcholinesterase	0.0209	0.628	1
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0039	0.0495	0.0495
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.1232	0.1962
Trichomonas vaginalis	tubulin, putative	0.0057	0.1104	0.1104
Loa Loa (eye worm)	BEN-1 protein	0.0057	0.1104	0.1758
Entamoeba histolytica	leucine rich repeat / protein phosphatase 2C domain containing protein	0.0117	0.3136	0.2779
Loa Loa (eye worm)	carboxylesterase	0.0035	0.0357	0.0569
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0178	0.52	0.8279
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0057	0.1104	0.1104
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0056	0.1043	0.1661
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.1104	0.1104
Brugia malayi	jmjC domain containing protein	0.0064	0.1336	0.2127
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0064	0.1336	0.2127
Brugia malayi	Tubulin beta-1 chain	0.0057	0.1104	0.1758
Brugia malayi	alpha-tubulin	0.0057	0.1104	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0357	0.0569
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.1232	0.2768
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0158	0.0252
Schistosoma mansoni	lipoxygenase	0.0056	0.1043	0.1661
Schistosoma mansoni	tubulin subunit alpha	0.0057	0.1104	0.1758
Schistosoma mansoni	alpha tubulin	0.0057	0.1104	0.1758
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.1104	0.1104
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.1104	0.1104
Echinococcus granulosus	tubulin alpha chain	0.0057	0.1104	0.1758
Trypanosoma brucei	beta tubulin	0.0057	0.1104	1
Loa Loa (eye worm)	BEN-1 protein	0.0057	0.1104	0.1758
Echinococcus multilocularis	tubulin alpha chain	0.0057	0.1104	0.1758
Giardia lamblia	Fructose-bisphosphate aldolase	0.0319	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0032	0.0257	0.0257
Brugia malayi	Carboxylesterase family protein	0.0035	0.0357	0.0569
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0057	0.1104	0.1758
Onchocerca volvulus		0.0035	0.0357	0.0285
Schistosoma mansoni	alpha tubulin	0.0057	0.1104	0.1758
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0032	0.0257	0.0257
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	1	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0319	1	1
Toxoplasma gondii	beta tubulin	0.0057	0.1104	0.8959
Loa Loa (eye worm)	hypothetical protein	0.0164	0.4741	0.7549
Echinococcus multilocularis	lysine specific demethylase 5A	0.0064	0.1336	0.2127
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0357	0.0569
Echinococcus multilocularis	Tubulin beta 2C chain	0.0057	0.1104	0.1758
Brugia malayi	Pre-SET motif family protein	0.003	0.0158	0.0252
Loa Loa (eye worm)	tubulin alpha chain	0.0057	0.1104	0.1758
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0039	0.0495	0.0495
Plasmodium falciparum	alpha tubulin 1	0.0057	0.1104	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0158	0.0252
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.1232	0.2768
Onchocerca volvulus		0.0036	0.0386	0.0326
Entamoeba histolytica	tubulin alpha chain, putative	0.0057	0.1104	0.0641
Brugia malayi	Carboxylesterase family protein	0.0209	0.628	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.1232	0.1962
Loa Loa (eye worm)	carboxylesterase	0.0209	0.628	1
Giardia lamblia	Beta tubulin	0.0057	0.1104	0.1104
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0057	0.1104	0.1104
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0039	0.0495	0.4015
Brugia malayi	Tubulin alpha chain	0.0057	0.1104	0.1758
Brugia malayi	Tubulin alpha-2 chain	0.0057	0.1104	0.1758
Loa Loa (eye worm)	tubulin beta chain	0.0057	0.1104	0.1758
Trypanosoma brucei	beta tubulin	0.0057	0.1104	1
Echinococcus granulosus	acetylcholinesterase	0.0209	0.628	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0057	0.1104	0.1758
Schistosoma mansoni	alpha tubulin	0.0057	0.1104	0.1758
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0158	0.0252
Leishmania major	alpha tubulin	0.0057	0.1104	0.8959
Brugia malayi	Tubulin beta chain	0.0032	0.0257	0.0409
Trichomonas vaginalis	tubulin alpha chain, putative	0.0032	0.0257	0.0257
Echinococcus granulosus	neuroligin	0.0035	0.0357	0.0569
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0032	0.0257	0.0409
Schistosoma mansoni	alpha-glucosidase	0.0153	0.4358	0.6938
Onchocerca volvulus		0.0035	0.0357	0.0285
Onchocerca volvulus		0.0035	0.0357	0.0285
Echinococcus granulosus	lysosomal alpha glucosidase	0.0178	0.52	0.8279
Echinococcus granulosus	Tubulin alpha 1 chain	0.0057	0.1104	0.1758
Loa Loa (eye worm)	alpha-tubulin	0.0057	0.1104	0.1758
Loa Loa (eye worm)	tubulin beta-2A chain	0.0057	0.1104	0.1758
Toxoplasma gondii	beta-1 tubulin, putative	0.0057	0.1104	0.8959
Brugia malayi	Carboxylesterase family protein	0.0035	0.0357	0.0569
Giardia lamblia	Beta tubulin	0.0057	0.1104	0.1104
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0319	1	1
Leishmania major	alpha tubulin	0.0057	0.1104	0.8959
Schistosoma mansoni	tubulin subunit gamma	0.0057	0.1104	0.1758
Echinococcus multilocularis	tubulin subunit TubB	0.0057	0.1104	0.1758
Toxoplasma gondii	alpha-tubulin I, putative	0.0057	0.1104	0.8959
Trichomonas vaginalis	tubulin alpha chain, putative	0.0032	0.0257	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0357	0.0569
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Leishmania major	alpha tubulin	0.0057	0.1104	0.8959
Trichomonas vaginalis	tubulin gamma chain, putative	0.0057	0.1104	0.1104
Echinococcus multilocularis	para nitrobenzyl esterase	0.0035	0.0357	0.0569
Onchocerca volvulus		0.0234	0.7131	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0057	0.1104	0.1758
Trichomonas vaginalis	spcc417.12 protein, putative	0.0035	0.0357	0.0357
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0158	0.1285
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0064	0.1336	0.2127
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0057	0.1104	0.1104
Giardia lamblia	Alpha-tubulin	0.0057	0.1104	0.1104
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.1232	0.1962
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0035	0.0357	0.0357
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Echinococcus granulosus	peroxisome assembly protein 26	0.0057	0.1104	0.1758
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0057	0.1104	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0357	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1104	0.1758
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0039	0.0495	0.0495
Loa Loa (eye worm)	beta-tubulin	0.0057	0.1104	0.1758
Plasmodium vivax	tubulin gamma chain, putative	0.0057	0.1104	1
Trypanosoma brucei	epsilon tubulin	0.0057	0.1104	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0158	0.0252
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0178	0.52	0.8279
Loa Loa (eye worm)	tubulin alpha 2	0.0032	0.0257	0.0409
Giardia lamblia	Alpha-tubulin	0.0057	0.1104	0.1104
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0058	0.1117	0.251
Schistosoma mansoni	single-minded	0.0049	0.0819	0.1304
Brugia malayi	hypothetical protein	0.0164	0.4741	0.7549
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0257	0.0409
Schistosoma mansoni	jumonji domain containing protein	0.0064	0.1336	0.2127
Trichomonas vaginalis	set domain proteins, putative	0.0234	0.7131	0.7131
Echinococcus multilocularis	peroxisome assembly protein 26	0.0057	0.1104	0.1758
Brugia malayi	PAS domain containing protein	0.0049	0.0819	0.1304
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0057	0.1104	0.1104
Echinococcus multilocularis	carboxylesterase 5A	0.0209	0.628	1
Echinococcus multilocularis	tubulin alpha	0.0057	0.1104	0.1758
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0156	0.4452	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0058	0.1117	0.251
Echinococcus granulosus	tubulin alpha chain	0.0057	0.1104	0.1758
Echinococcus multilocularis	neuroligin	0.0035	0.0357	0.0569
Leishmania major	alpha tubulin	0.0057	0.1104	0.8959
Echinococcus multilocularis	Tubulin beta 2C chain	0.0057	0.1104	0.1758
Echinococcus multilocularis	tubulin alpha 1C chain	0.0057	0.1104	0.1758
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0158	0.0252
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0035	0.0357	0.0569
Giardia lamblia	Gamma tubulin	0.0057	0.1104	0.1104
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0035	0.0357	0.0569
Trichomonas vaginalis	tubulin beta chain, putative	0.0057	0.1104	0.1104
Loa Loa (eye worm)	hypothetical protein	0.0117	0.313	0.4985
Mycobacterium ulcerans	putative regulatory protein	0.0036	0.0386	0.0867
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0495	0.4482
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Leishmania major	alpha tubulin	0.0057	0.1104	0.8959
Echinococcus granulosus	Tubulin alpha 1 chain	0.0057	0.1104	0.1758
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0057	0.1104	0.1104
Trypanosoma brucei	beta tubulin	0.0057	0.1104	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0057	0.1104	0.1758
Trypanosoma cruzi	beta tubulin, putative	0.0057	0.1104	1
Schistosoma mansoni	gliotactin	0.0035	0.0357	0.0569
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0035	0.0357	0.0803
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0064	0.1336	0.2127
Plasmodium vivax	tubulin epsilon chain, putative	0.0057	0.1104	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0057	0.1104	0.1758
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0035	0.0357	0.0569
Brugia malayi	beta-tubulin, identical	0.0057	0.1104	0.1758
Leishmania major	beta tubulin	0.0057	0.1104	0.8959
Leishmania major	alpha tubulin	0.0057	0.1104	0.8959
Echinococcus granulosus	single minded 2	0.0036	0.0386	0.0614
Leishmania major	alpha tubulin	0.0057	0.1104	0.8959
Echinococcus multilocularis	tubulin alpha chain	0.0057	0.1104	0.1758
Echinococcus granulosus	para nitrobenzyl esterase	0.0035	0.0357	0.0569
Echinococcus multilocularis	tubulin alpha 1C chain	0.0057	0.1104	0.1758
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0357	0.0569
Entamoeba histolytica	tubulin alpha-1 chain	0.0057	0.1104	0.0641
Leishmania major	alpha tubulin	0.0057	0.1104	0.8959
Leishmania major	alpha tubulin	0.0057	0.1104	0.8959
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0057	0.1104	0.1758
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0035	0.0357	0.0569
Schistosoma mansoni	tubulin subunit beta	0.0057	0.1104	0.1758
Plasmodium vivax	tubulin beta chain, putative	0.0057	0.1104	1
Schistosoma mansoni	tubulin subunit beta	0.0057	0.1104	0.1758
Loa Loa (eye worm)	tubulin alpha 2	0.0032	0.0257	0.0409
Toxoplasma gondii	alpha tubulin TUBA1	0.0057	0.1104	0.8959
Trichomonas vaginalis	tubulin alpha chain, putative	0.0057	0.1104	0.1104

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 664694