Detailed information for compound 665045

Basic information

Technical information
  • TDR Targets ID: 665045
  • Name: 1-[3-(2-chloro-4-methylphenoxy)propyl]imidazo le
  • MW: 250.724 | Formula: C13H15ClN2O
  • H donors: 0 H acceptors: 1 LogP: 2.96 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)Cl)OCCCn1cncc1
  • InChi: 1S/C13H15ClN2O/c1-11-3-4-13(12(14)9-11)17-8-2-6-16-7-5-15-10-16/h3-5,7,9-10H,2,6,8H2,1H3
  • InChiKey: UXUICNOBSTWMQK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[3-(2-chloro-4-methyl-phenoxy)propyl]imidazole
  • BIM-0042711.P001
  • ZINC02901597
  • CBMicro_042585

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0237 0.261 1
Mycobacterium ulcerans hydrolase 0.0016 0.0071 0.4097
Leishmania major histone deacetylase, putative 0.0237 0.261 0.6365
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0016 0.0071 0.007
Brugia malayi Zinc carboxypeptidase family protein 0.0058 0.0561 0.1377
Toxoplasma gondii zinc carboxypeptidase, putative 0.0058 0.0561 0.1858
Schistosoma mansoni cpg binding protein 0.0031 0.0249 0.0343
Mycobacterium ulcerans hydrolase 0.0016 0.0071 0.4097
Echinococcus granulosus cytosolic carboxypeptidase 1 0.0058 0.0561 0.0948
Trypanosoma cruzi glyoxalase II 0.0016 0.0071 0.0057
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0561 0.1929
Schistosoma mansoni family M14 non-peptidase homologue (M14 family) 0.0058 0.0561 0.0876
Mycobacterium ulcerans beta lactamase-like protein 0.0016 0.0071 0.4097
Brugia malayi Zinc carboxypeptidase family protein 0.0058 0.0561 0.1377
Trypanosoma cruzi histone deacetylase 1, putative 0.0237 0.261 0.6365
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0048 0.0079
Echinococcus multilocularis histone deacetylase 7 0.0254 0.2809 0.2808
Trichomonas vaginalis histone deacetylase, putative 0.0237 0.261 1
Brugia malayi Cytochrome P450 family protein 0.0014 0.0048 0.0118
Echinococcus multilocularis cpg binding protein 0.0033 0.0269 0.0268
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0016 0.0071 0.4097
Leishmania major hypothetical protein, conserved 0.0016 0.0071 0.0057
Schistosoma mansoni histone deacetylase hda2 0.026 0.2879 0.4835
Leishmania major histone deacetylase, putative 0.0237 0.261 0.6365
Echinococcus multilocularis histone deacetylase 0.0254 0.2809 0.2808
Mycobacterium tuberculosis Conserved protein 0.0016 0.0071 0.4097
Onchocerca volvulus Carboxypeptidase D homolog 0.0058 0.0561 0.1316
Echinococcus multilocularis geminin 0.0523 0.5903 0.5903
Mycobacterium tuberculosis Beta lactamase like protein 0.0016 0.0071 0.4097
Echinococcus granulosus zinc phosphodiesterase 0.0016 0.0071 0.0118
Echinococcus granulosus histone deacetylase 6 0.026 0.2879 0.4875
Brugia malayi Zinc carboxypeptidase family protein 0.0058 0.0561 0.1377
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0058 0.0561 0.1929
Onchocerca volvulus 0.0058 0.0561 0.1316
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0461 0.1128
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0016 0.0071 0.0171
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0016 0.0071 0.0171
Toxoplasma gondii histone deacetylase HDAC2 0.0237 0.261 0.9281
Schistosoma mansoni ap endonuclease 0.0019 0.0104 0.0096
Echinococcus multilocularis histone deacetylase 6 0.0254 0.2809 0.2808
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0104 1
Brugia malayi Zinc carboxypeptidase family protein 0.0058 0.0561 0.1377
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0058 0.0561 0.1274
Schistosoma mansoni hypothetical protein 0.0048 0.0439 0.0667
Trypanosoma brucei histone deacetylase, putative 0.0254 0.2809 0.6858
Plasmodium vivax histone deacetylase, putative 0.0102 0.106 0.3611
Brugia malayi metallo-beta-lactamase superfamily protein 0.0016 0.0071 0.0174
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0104 0.0131
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0249 0.0607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0461 0.0705
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0016 0.0071 0.0118
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.034 0.3795 0.6399
Trypanosoma brucei histone deacetylase 4 0.0254 0.2809 0.6858
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0561 0.1929
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0561 0.1929
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0104 1
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0016 0.0071 0.0084
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0364 0.4073 1
Onchocerca volvulus 0.034 0.3795 1
Onchocerca volvulus 0.0048 0.0439 0.0987
Trypanosoma cruzi histone deacetylase, putative 0.0102 0.106 0.2513
Brugia malayi histone deacetylase 1 (HD1) 0.0237 0.261 0.6408
Plasmodium falciparum histone deacetylase 1 0.0237 0.261 0.9275
Loa Loa (eye worm) hypothetical protein 0.0058 0.0561 0.1374
Brugia malayi hypothetical protein 0.0234 0.2577 0.6326
Loa Loa (eye worm) hypothetical protein 0.0158 0.171 0.4195
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0016 0.0071 0.0057
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0171
Schistosoma mansoni peptidase 0.0058 0.0561 0.0876
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0104 0.014
Echinococcus multilocularis Zinc carboxypeptidase family protein 0.0058 0.0561 0.056
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14 0.0058 0.0561 0.1274
Loa Loa (eye worm) hypothetical protein 0.0058 0.0561 0.1374
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0104 0.014
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0016 0.0071 0.0171
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0171
Brugia malayi metallo-beta-lactamase superfamily protein 0.0016 0.0071 0.0174
Schistosoma mansoni histone deacetylase 4 5 0.0254 0.2809 0.4715
Brugia malayi Zinc carboxypeptidase family protein 0.0058 0.0561 0.1377
Schistosoma mansoni histone deacetylase 1 2 3 0.0102 0.106 0.1728
Loa Loa (eye worm) CYP4Cod1 0.0014 0.0048 0.0114
Onchocerca volvulus 0.034 0.3795 1
Trypanosoma brucei histone deacetylase 3 0.0254 0.2809 0.6858
Loa Loa (eye worm) hypothetical protein 0.0102 0.106 0.2599
Schistosoma mansoni metallocarboxypeptidase D peptidase unit 2 (M14 family) 0.0058 0.0561 0.0876
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.026 0.0635
Leishmania major C-8 sterol isomerase-like protein 0.0364 0.4073 1
Plasmodium vivax histone deacetylase 1, putative 0.0237 0.261 0.9275
Chlamydia trachomatis ribonuclease Z 0.0016 0.0071 0.5
Echinococcus granulosus cytosolic carboxypeptidase protein 5 0.0058 0.0561 0.0948
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0439 0.1077
Brugia malayi Cytochrome P450 family protein 0.0014 0.0048 0.0118
Mycobacterium leprae Beta-lactamase-like protein 0.0016 0.0071 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0461 0.0779
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0104 0.0253
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0461 0.046
Loa Loa (eye worm) histone deacetylase 1 0.0237 0.261 0.6406
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0016 0.0071 0.0057
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0048 0.0114
Schistosoma mansoni hypothetical protein 0.0058 0.0561 0.0876
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0461 0.1131
Loa Loa (eye worm) hypothetical protein 0.0364 0.4073 1
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0561 0.1929
Schistosoma mansoni zinc phosphodiesterase 0.0016 0.0071 0.0039
Mycobacterium leprae POSSIBLE HYDROLASE 0.0016 0.0071 1
Onchocerca volvulus Cytosolic carboxypeptidase 1 homolog 0.0058 0.0561 0.1316
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0058 0.0561 0.1274
Schistosoma mansoni histone deacetylase 4 5 0.0254 0.2809 0.4715
Brugia malayi Zinc carboxypeptidase family protein 0.0058 0.0561 0.1377
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0171
Trypanosoma brucei Carboxypeptidase-like protein 0.0058 0.0561 0.1274
Loa Loa (eye worm) zinc carboxypeptidase 0.0058 0.0561 0.1374
Loa Loa (eye worm) hypothetical protein 0.0058 0.0561 0.1374
Leishmania major metallo-beta-lactamase family protein-like protein 0.0016 0.0071 0.0057
Schistosoma mansoni survival motor neuron protein 0.0048 0.0439 0.0667
Onchocerca volvulus 0.034 0.3795 1
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0561 0.1929
Echinococcus multilocularis 0.0014 0.0048 0.0046
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0058 0.0561 0.1274
Trypanosoma cruzi Carboxypeptidase-like protein 0.0058 0.0561 0.1274
Echinococcus multilocularis histone deacetylase 6 0.0254 0.2809 0.2808
Mycobacterium ulcerans hypothetical protein 0.0016 0.0071 0.4097
Echinococcus multilocularis histone deacetylase 8 0.0102 0.106 0.1058
Schistosoma mansoni histone deacetylase hda2 0.0102 0.106 0.1728
Brugia malayi ethe1-prov protein 0.0016 0.0071 0.0174
Loa Loa (eye worm) hypothetical protein 0.0058 0.0561 0.1374
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0561 0.1789
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0104 0.0131
Entamoeba histolytica histone deacetylase, putative 0.0237 0.261 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0104 0.014
Trypanosoma cruzi histone deacetylase, putative 0.0254 0.2809 0.6858
Onchocerca volvulus 0.0031 0.0249 0.0477
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0104 0.014
Trichomonas vaginalis histone deacetylase, putative 0.0237 0.261 1
Echinococcus granulosus cpg binding protein 0.0033 0.0269 0.0454
Loa Loa (eye worm) hypothetical protein 0.0058 0.0561 0.1374
Schistosoma mansoni peptidase 0.0058 0.0561 0.0876
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0058 0.0561 0.1858
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0058 0.0561 0.1274
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0016 0.0071 0.0057
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0561 0.1929
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0104 0.0131
Trypanosoma brucei glyoxalase II 0.0016 0.0071 0.0057
Trichomonas vaginalis histone deacetylase, putative 0.0237 0.261 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0569 0.1887
Echinococcus granulosus histone deacetylase 3 0.0237 0.261 0.442
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0071 0.4097
Loa Loa (eye worm) hypothetical protein 0.0058 0.0561 0.1374
Trypanosoma cruzi histone deacetylase 1, putative 0.0237 0.261 0.6365
Leishmania major histone deacetylase, putative 0.0254 0.2809 0.6858
Brugia malayi Zinc carboxypeptidase family protein 0.0058 0.0561 0.1377
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0561 0.1929
Loa Loa (eye worm) zinc carboxypeptidase 0.0058 0.0561 0.1374
Toxoplasma gondii histone deacetylase HDAC1 0.0254 0.2809 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0104 1
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0016 0.0071 0.0039
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0016 0.0071 0.007
Trypanosoma brucei histone deacetylase 2 0.0102 0.106 0.2513
Leishmania major metallo-beta-lactamase family-like protein 0.0016 0.0071 0.0057
Echinococcus granulosus histone deacetylase 0.0254 0.2809 0.4756
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0016 0.0071 0.0057
Mycobacterium ulcerans hydrolase 0.0016 0.0071 0.4097
Loa Loa (eye worm) hypothetical protein 0.0058 0.0561 0.1374
Trypanosoma cruzi histone deacetylase, putative 0.0254 0.2809 0.6858
Echinococcus granulosus histone deacetylase 8 0.0102 0.106 0.1793
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0461 0.0705
Schistosoma mansoni histone deacetylase 0.0237 0.261 0.4376
Trypanosoma cruzi glyoxalase II 0.0016 0.0071 0.0057
Brugia malayi Carboxypeptidase A2 precursor 0.0058 0.0561 0.1377
Leishmania major histone deacetylase, putative 0.0254 0.2809 0.6858
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0104 0.0174
Onchocerca volvulus 0.034 0.3795 1
Echinococcus multilocularis cytosolic carboxypeptidase protein 5 0.0058 0.0561 0.056
Toxoplasma gondii histone deacetylase HDAC3 0.0237 0.261 0.9281
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0039
Brugia malayi Histone deacetylase family protein 0.0254 0.2809 0.6895
Echinococcus multilocularis histone deacetylase 1 0.0237 0.261 0.2609
Brugia malayi Cytochrome P450 family protein 0.0014 0.0048 0.0118
Loa Loa (eye worm) hypothetical protein 0.0281 0.3125 0.767
Toxoplasma gondii exonuclease III APE 0.0019 0.0104 0.0204
Loa Loa (eye worm) histone deacetylase 0.0254 0.2809 0.6894
Schistosoma mansoni peptidase 0.0058 0.0561 0.0876
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0016 0.0071 0.0174
Echinococcus multilocularis zinc phosphodiesterase 0.0016 0.0071 0.007
Echinococcus granulosus dnaJ subfamily B 0.0444 0.499 0.8452
Echinococcus multilocularis ETHE1 protein 0.0016 0.0071 0.007
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0561 0.1929
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0058 0.0561 0.1929
Schistosoma mansoni histone deacetylase 0.0237 0.261 0.4376
Echinococcus multilocularis histone deacetylase 3 0.0237 0.261 0.2609
Brugia malayi Histone deacetylase 1 0.0237 0.261 0.6408
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0016 0.0071 0.007
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0016 0.0071 0.0118
Schistosoma mansoni cpg binding protein 0.0033 0.0269 0.0378
Brugia malayi CXXC zinc finger family protein 0.0031 0.0249 0.0611
Mycobacterium ulcerans glyoxalase II, GloB 0.0016 0.0071 0.4097
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0016 0.0071 0.0118
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0016 0.0071 0.0057
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0016 0.0071 0.0057
Schistosoma mansoni protease m14 carboxypeptidase 0.0058 0.0561 0.0876
Loa Loa (eye worm) zinc carboxypeptidase 0.0058 0.0561 0.1374
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0058 0.0561 0.1929
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0039
Loa Loa (eye worm) cytochrome P450 0.0014 0.0048 0.0114
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0104 0.0122
Loa Loa (eye worm) hypothetical protein 0.0152 0.164 0.4023
Toxoplasma gondii flagellar/basal body protein 0.0058 0.0561 0.1858
Trypanosoma cruzi glyoxalase II 0.0016 0.0071 0.0057
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0237 0.261 1
Schistosoma mansoni zinc phosphodiesterase 0.0016 0.0071 0.0039
Plasmodium falciparum histone deacetylase, putative 0.0254 0.2809 1
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0058 0.0561 0.1274
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0071 0.4097
Echinococcus granulosus histone deacetylase 7 0.0254 0.2809 0.4756
Schistosoma mansoni hypothetical protein 0.0444 0.499 0.844
Loa Loa (eye worm) histone deacetylase 7A 0.0254 0.2809 0.6894
Loa Loa (eye worm) hypothetical protein 0.0234 0.2577 0.6325
Mycobacterium ulcerans hypothetical protein 0.0016 0.0071 0.4097
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0058 0.0561 0.1858
Plasmodium vivax histone deacetylase 2, putative 0.0254 0.2809 1
Schistosoma mansoni hypothetical protein 0.0523 0.5903 1
Echinococcus multilocularis histone deacetylase 6 0.026 0.2879 0.2878
Echinococcus granulosus histone deacetylase 6 0.0254 0.2809 0.4756
Plasmodium falciparum histone deacetylase 2 0.0254 0.2809 1
Trypanosoma brucei C-8 sterol isomerase, putative 0.0364 0.4073 1
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0071 1
Echinococcus granulosus geminin 0.0523 0.5903 1
Schistosoma mansoni hypothetical protein 0.0523 0.5903 1
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0016 0.0071 0.0057
Trichomonas vaginalis histone deacetylase, putative 0.0237 0.261 1
Schistosoma mansoni ap endonuclease 0.0019 0.0104 0.0096
Echinococcus granulosus ETHE1 protein 0.0016 0.0071 0.0118
Brugia malayi cytochrome P450 0.0014 0.0048 0.0118
Brugia malayi hypothetical protein 0.0016 0.0071 0.0174
Echinococcus granulosus Zinc carboxypeptidase family protein 0.0058 0.0561 0.0948
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0016 0.0071 0.0084
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0364 0.4073 1
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0016 0.0071 0.0057
Brugia malayi histone deacetylase 11 0.0102 0.106 0.2601
Loa Loa (eye worm) hypothetical protein 0.0058 0.0561 0.1374
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.034 0.3795 0.3794
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0104 1
Loa Loa (eye worm) zinc carboxypeptidase 0.0058 0.0561 0.1374
Giardia lamblia Histone deacetylase 0.0237 0.261 1
Mycobacterium tuberculosis Possible hydrolase 0.0016 0.0071 0.4097
Loa Loa (eye worm) hypothetical protein 0.0186 0.2028 0.4978
Loa Loa (eye worm) histone deacetylase 11 0.0102 0.106 0.2599
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0058 0.0561 0.1274
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0104 0.0256
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0171
Mycobacterium leprae conserved hypothetical protein 0.0016 0.0071 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0461 0.0779
Trichomonas vaginalis histone deacetylase, putative 0.0237 0.261 1
Brugia malayi Zinc carboxypeptidase family protein 0.0058 0.0561 0.1377
Brugia malayi Cytochrome P450 family protein 0.0032 0.026 0.0638
Loa Loa (eye worm) cytochrome P450 family protein 0.0014 0.0048 0.0114
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.065 0.1028
Loa Loa (eye worm) hypothetical protein 0.0058 0.0561 0.1374
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0058 0.0561 0.1274
Onchocerca volvulus 0.0058 0.0561 0.1316
Brugia malayi histone deacetylase 3 (HD3) 0.0237 0.261 0.6408
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.2577 0.4364
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0104 0.0131
Trypanosoma cruzi histone deacetylase, putative 0.0254 0.2809 0.6858
Loa Loa (eye worm) histone deacetylase 3 0.0237 0.261 0.6406
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.2577 0.2576
Mycobacterium ulcerans hypothetical protein 0.0016 0.0071 0.4097
Onchocerca volvulus Histone deacetylase 10 homolog 0.0102 0.106 0.2655
Echinococcus granulosus subfamily M14A unassigned peptidase 0.034 0.3795 0.6427
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0104 0.0103
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0104 0.0122
Echinococcus multilocularis dnaJ subfamily B 0.0444 0.499 0.4989
Mycobacterium tuberculosis Conserved protein 0.0016 0.0071 0.4097
Echinococcus granulosus histone deacetylase 1 0.0237 0.261 0.442
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0461 0.046
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0016 0.0071 0.0057
Plasmodium vivax histone deacetylase, putative 0.0254 0.2809 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0071 0.4097
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0561 0.1929
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0016 0.0071 0.0057
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0561 0.1929
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0237 0.261 1
Trypanosoma brucei histone deacetylase 1 0.0237 0.261 0.6365
Mycobacterium tuberculosis Possible hydrolase 0.0016 0.0071 0.4097
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0016 0.0071 0.0057
Brugia malayi Histone deacetylase family protein 0.0254 0.2809 0.6895
Mycobacterium ulcerans hypothetical protein 0.0016 0.0071 0.4097
Loa Loa (eye worm) hypothetical protein 0.0237 0.261 0.6406
Trypanosoma cruzi histone deacetylase, putative 0.0102 0.106 0.2513
Toxoplasma gondii histone deacetylase HDAC4 0.0102 0.106 0.3665
Echinococcus multilocularis 0.0058 0.0561 0.056
Toxoplasma gondii histone deacetylase HDAC5 0.0102 0.106 0.3665
Echinococcus granulosus histone deacetylase 6 0.0254 0.2809 0.4756
Trichomonas vaginalis histone deacetylase, putative 0.0237 0.261 1
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0058 0.0561 0.1929
Mycobacterium tuberculosis Conserved protein 0.0016 0.0071 0.4097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0461 0.0705
Loa Loa (eye worm) hypothetical protein 0.0058 0.0561 0.1374
Schistosoma mansoni carboxypeptidase N (M14 family) 0.0058 0.0561 0.0876
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0039
Trypanosoma cruzi zinc carboxypeptidase, putative 0.0058 0.0561 0.1274
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.034 0.3795 1
Schistosoma mansoni cpg binding protein 0.0033 0.0269 0.0378

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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