Detailed information for compound 668911

Basic information

Technical information
  • TDR Targets ID: 668911
  • Name: 4-[3-(4-tert-butylphenoxy)propyl]-2,6-dimethy lmorpholine
  • MW: 305.455 | Formula: C19H31NO2
  • H donors: 0 H acceptors: 0 LogP: 4.45 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CN(CCCOc2ccc(cc2)C(C)(C)C)CC(O1)C
  • InChi: 1S/C19H31NO2/c1-15-13-20(14-16(2)22-15)11-6-12-21-18-9-7-17(8-10-18)19(3,4)5/h7-10,15-16H,6,11-14H2,1-5H3
  • InChiKey: OXVPDCJLDRLJJL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[3-(4-tert-butylphenoxy)propyl]-2,6-dimethyl-morpholine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0528 0.1381
Trichomonas vaginalis malate dehydrogenase, putative 0.0279 0.2963 0.4343
Plasmodium falciparum malate dehydrogenase 0.0717 0.8148 1
Brugia malayi Kelch motif family protein 0.012 0.1088 0.1329
Echinococcus multilocularis integrin alpha ps 0.0047 0.0227 0.0227
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0368 0.0444
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0343 0.3729 0.4573
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0064 0.0071
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1641 0.2378
Giardia lamblia DINP protein human, muc B family 0.02 0.2034 0.2998
Leishmania major malate dehydrogenase 0.0279 0.2963 0.3605
Giardia lamblia Kinase, PLK 0.06 0.677 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0077 0.0054
Schistosoma mansoni kinase 0.0305 0.3277 0.4017
Echinococcus multilocularis malate dehydrogenase 0.0279 0.2963 0.2963
Echinococcus granulosus lactate dehydrogenase protein 0.0717 0.8148 1
Echinococcus granulosus cytosolic malate dehydrogenase 0.0279 0.2963 0.3637
Echinococcus granulosus integrin alpha ps 0.0099 0.0835 0.1025
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.1641 0.2417
Loa Loa (eye worm) hypothetical protein 0.0062 0.0401 0.0485
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0528 0.0602
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0214 0.0262
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.2675 0.3279
Trypanosoma cruzi DNA polymerase kappa, putative 0.02 0.2034 0.2962
Echinococcus multilocularis thioredoxin glutathione reductase 0.0116 0.104 0.104
Trypanosoma brucei chrX additional, unordered contigs 0.0062 0.0401 0.0536
Trypanosoma brucei hypothetical protein, conserved 0.0062 0.0401 0.0536
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0528 0.0642
Schistosoma mansoni serine/threonine protein kinase 0.06 0.677 0.8308
Mycobacterium ulcerans hypothetical protein 0.0062 0.0401 0.0933
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.004 0.0136 0.016
Mycobacterium ulcerans hypothetical protein 0.0073 0.0528 0.1381
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0136 0.0142
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0279 0.2963 0.4343
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0717 0.8148 0.8148
Trypanosoma brucei DNA damage repair protein, putative 0.0062 0.0401 0.0536
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0401 0.0536
Echinococcus multilocularis malate dehydrogenase 0.0279 0.2963 0.2963
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0136 0.0142
Plasmodium vivax malate dehydrogenase, putative 0.0717 0.8148 1
Trypanosoma brucei unspecified product 0.0138 0.1299 0.187
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0136 0.0142
Leishmania major hypothetical protein, conserved 0.0035 0.0077 0.0045
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0049 0.0249 0.0298
Toxoplasma gondii malate dehydrogenase MDH 0.0717 0.8148 1
Giardia lamblia DNA damage repair protein 0.0062 0.0401 0.0584
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0526 0.0638
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.1299 0.187
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.004 0.0136 0.0118
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.004 0.0136 0.016
Trichomonas vaginalis CAMK family protein kinase 0.06 0.677 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.0911 0.1112
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2675 0.3915
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.004 0.0136 0.016
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0343 0.3729 0.4573
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0077 0.0054
Leishmania major cytosolic malate dehydrogenase 0.0279 0.2963 0.3605
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0519 0.0631
Loa Loa (eye worm) hypothetical protein 0.0054 0.031 0.0374
Plasmodium falciparum glutathione reductase 0.0115 0.1022 0.1247
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2675 0.3915
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0433 0.4791 0.5877
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0275 0.047
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.4432 0.4432
Plasmodium vivax glutathione reductase, putative 0.0115 0.1022 0.1247
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0077 0.0087
Brugia malayi Integrin beta pat-3 precursor 0.0586 0.66 0.8099
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0528 0.1323
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0261 0.2758 0.866
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.06 0.677 0.8308
Schistosoma mansoni rotamase 0.0032 0.0049 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0136 0.0142
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0077 0.0094
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0154 0.0182
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0261 0.2758 0.8837
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.1299 0.187
Trypanosoma brucei trypanothione reductase 0.0115 0.1022 0.1458
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.2034 0.2962
Brugia malayi hypothetical protein 0.0162 0.1587 0.1942
Trypanosoma cruzi DNA damage repair protein, putative 0.0062 0.0401 0.0536
Loa Loa (eye worm) hypothetical protein 0.0054 0.031 0.0374
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.3183 0.467
Trypanosoma cruzi trypanothione reductase, putative 0.0115 0.1022 0.1458
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1641 0.2378
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0261 0.0328
Loa Loa (eye worm) hypothetical protein 0.02 0.2034 0.2491
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0077 0.0087
Mycobacterium tuberculosis Probable dehydrogenase 0.0261 0.2758 0.8837
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0064 0.0071
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.004 0.0136 0.016
Trichomonas vaginalis malate dehydrogenase, putative 0.0279 0.2963 0.4343
Trichomonas vaginalis glutaminase, putative 0.028 0.2977 0.4364
Plasmodium falciparum L-lactate dehydrogenase 0.0717 0.8148 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0241 0.2516 0.3083
Brugia malayi hypothetical protein 0.012 0.1088 0.1329
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1641 0.2378
Echinococcus multilocularis integrin alpha ps 0.0099 0.0835 0.0835
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.06 0.677 0.677
Onchocerca volvulus 0.0105 0.0911 0.1338
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.3137 0.4601
Toxoplasma gondii cathepsin CPC1 0.0127 0.1174 0.1434
Brugia malayi CXXC zinc finger family protein 0.0114 0.101 0.1233
Trypanosoma brucei polo-like protein kinase 0.06 0.677 1
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2675 0.3915
Trichomonas vaginalis malate dehydrogenase, putative 0.0279 0.2963 0.4343
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0077 0.0087
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0154 0.0169
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0077 0.0087
Echinococcus multilocularis geminin 0.0338 0.3669 0.3669
Leishmania major DNA polymerase eta, putative 0.02 0.2034 0.2459
Mycobacterium ulcerans DNA polymerase IV 0.02 0.2034 0.668
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.0528 0.1381
Echinococcus multilocularis dna polymerase eta 0.02 0.2034 0.2034
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0528 0.1381
Loa Loa (eye worm) hypothetical protein 0.0051 0.0275 0.033
Mycobacterium tuberculosis Toxin MazF9 0.0133 0.1245 0.3737
Mycobacterium ulcerans hypothetical protein 0.0133 0.1245 0.3902
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0528 0.1381
Plasmodium vivax thioredoxin reductase, putative 0.0115 0.1022 0.1247
Echinococcus granulosus cytosolic malate dehydrogenase 0.0279 0.2963 0.3637
Trichomonas vaginalis malate dehydrogenase, putative 0.0279 0.2963 0.4343
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.004 0.0136 0.016
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.0528 0.1323
Echinococcus multilocularis cpg binding protein 0.012 0.1086 0.1086
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0077 0.0077
Brugia malayi polk-prov protein 0.0062 0.0401 0.0485
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0136 0.0142
Schistosoma mansoni glutaminase 0.028 0.2977 0.3649
Trypanosoma cruzi DNA polymerase kappa, putative 0.02 0.2034 0.2962
Echinococcus granulosus expressed protein 0.0032 0.0049 0.006
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0154 0.0189
Plasmodium falciparum lactate dehydrogenase, putative 0.0279 0.2963 0.3632
Trichomonas vaginalis mercuric reductase, putative 0.004 0.0136 0.0142
Brugia malayi Thioredoxin reductase 0.0115 0.1022 0.1247
Schistosoma mansoni terminal deoxycytidyl transferase 0.02 0.2034 0.2491
Entamoeba histolytica hypothetical protein 0.0072 0.0519 0.0591
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0127 0.1174 0.1434
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.02 0.2034 0.6397
Trypanosoma brucei unspecified product 0.02 0.2034 0.2962
Echinococcus granulosus GPCR family 2 0.0034 0.0064 0.0079
Onchocerca volvulus 0.0114 0.101 0.1484
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.0049 0.0053
Leishmania major DNA polymerase kappa, putative 0.0062 0.0401 0.0445
Echinococcus granulosus L lactate dehydrogenase B chain 0.0717 0.8148 1
Trichomonas vaginalis CAMK family protein kinase 0.06 0.677 1
Echinococcus granulosus dnaJ subfamily B 0.0403 0.4432 0.544
Loa Loa (eye worm) CXXC zinc finger family protein 0.0114 0.101 0.1233
Trichomonas vaginalis malate dehydrogenase, putative 0.0279 0.2963 0.4343
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0154 0.0169
Plasmodium vivax DNA repair protein REV1, putative 0.0062 0.0401 0.0485
Mycobacterium tuberculosis Probable oxidoreductase 0.029 0.3103 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.029 0.3103 1
Trichomonas vaginalis CAMK family protein kinase 0.06 0.677 1
Trichomonas vaginalis malate dehydrogenase, putative 0.0279 0.2963 0.4343
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.029 0.3103 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.0528 0.0642
Trichomonas vaginalis malate dehydrogenase, putative 0.0136 0.1272 0.1831
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0279 0.2963 0.2963
Brugia malayi glutaminase DH11.1 0.028 0.2977 0.3649
Trypanosoma cruzi malate dehydrogenase, putative 0.0279 0.2963 0.4343
Echinococcus multilocularis lactate dehydrogenase a 0.0717 0.8148 0.8148
Loa Loa (eye worm) hypothetical protein 0.0073 0.0528 0.0642
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0279 0.2963 0.4343
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0049 0.0013
Echinococcus multilocularis integrin beta 2 0.0586 0.66 0.66
Mycobacterium ulcerans glutaminase 0.028 0.2977 1
Brugia malayi jmjC domain containing protein 0.0094 0.0779 0.0949
Schistosoma mansoni jumonji domain containing protein 0.0075 0.055 0.0668
Mycobacterium tuberculosis Toxin MazF2 0.0133 0.1245 0.3737
Trypanosoma brucei glycosomal malate dehydrogenase 0.0279 0.2963 0.4343
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.02 0.2034 0.2496
Loa Loa (eye worm) hypothetical protein 0.0054 0.031 0.0374
Brugia malayi jmjC domain containing protein 0.0041 0.0154 0.0182
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0528 0.0602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0214 0.0255
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0064 0.0071
Entamoeba histolytica malate dehydrogenase, putative 0.0279 0.2963 0.3605
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0519 0.0638
Schistosoma mansoni cpg binding protein 0.012 0.1086 0.1327
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0528 0.0642
Schistosoma mansoni integrin alpha-4 0.0423 0.4666 0.5724
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0127 0.1174 0.1434
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2675 0.3915
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0279 0.2963 0.4343
Trypanosoma cruzi DNA polymerase kappa, putative 0.02 0.2034 0.2962
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.004 0.0136 0.0142
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0214 0.0214
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0528 0.0602
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0054 0.031 0.0374
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0035 0.0082 0.0101
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0214 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.2034 0.2962
Loa Loa (eye worm) malate dehydrogenase 0.0279 0.2963 0.3632
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0343 0.3729 0.4577
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.036 0.3932 0.3932
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0261 0.2758 0.8837
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.004 0.0136 0.0142
Trichomonas vaginalis malate dehydrogenase, putative 0.0279 0.2963 0.4343
Giardia lamblia NADH oxidase lateral transfer candidate 0.004 0.0136 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0401 0.0536
Toxoplasma gondii histone lysine methyltransferase SET1 0.0215 0.2211 0.2709
Toxoplasma gondii NADPH-glutathione reductase 0.004 0.0136 0.016
Onchocerca volvulus 0.0073 0.0528 0.0772
Trichomonas vaginalis DNA polymerase eta, putative 0.02 0.2034 0.2962
Schistosoma mansoni malate dehydrogenase 0.0279 0.2963 0.3632
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.031 0.0617
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0136 0.0142
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.06 0.677 0.8301
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.0111 0.0129
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0047 0.0227 0.0271
Loa Loa (eye worm) integrin alpha pat-2 0.0099 0.0835 0.1019
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.2675 0.3279
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.2034 0.2962
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.02 0.2034 0.2491
Mycobacterium tuberculosis Toxin MazF6 0.0133 0.1245 0.3737
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0154 0.0169
Trichomonas vaginalis rotamase, putative 0.0032 0.0049 0.0013
Mycobacterium ulcerans DNA polymerase IV 0.02 0.2034 0.668
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.02 0.2034 0.2459
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0275 0.047
Brugia malayi serine/threonine-protein kinase plk-2 0.06 0.677 0.8308
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.004 0.0136 0.0167
Treponema pallidum NADH oxidase 0.004 0.0136 0.5
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0136 0.0142
Loa Loa (eye worm) glutaminase 2 0.028 0.2977 0.3649
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0401 0.0536
Plasmodium vivax lactate dehydrogenase 0.0717 0.8148 1
Brugia malayi glutathione reductase 0.0115 0.1022 0.1247
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0154 0.0182
Trypanosoma brucei malate dehydrogenase-related 0.0279 0.2963 0.4343
Loa Loa (eye worm) glutathione reductase 0.0115 0.1022 0.1247
Leishmania major DNA polymerase eta, putative 0.0062 0.0401 0.0445
Trypanosoma brucei DNA polymerase IV, putative 0.02 0.2034 0.2962
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0064 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.2034 0.2962
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0127 0.1174 0.1434
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0519 0.0519
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.004 0.0136 0.0142
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1641 0.2378
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0261 0.2758 0.8837
Loa Loa (eye worm) hypothetical protein 0.0073 0.0528 0.0642
Schistosoma mansoni L-lactate dehydrogenase 0.0717 0.8148 1
Mycobacterium ulcerans hypothetical protein 0.0154 0.1494 0.4781
Trypanosoma brucei hypothetical protein, conserved 0.0062 0.0401 0.0536
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0011 0.0007
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0077 0.0087
Mycobacterium ulcerans malate dehydrogenase 0.0279 0.2963 0.9951
Entamoeba histolytica deoxycytidyl transferase, putative 0.02 0.2034 0.2459
Schistosoma mansoni integrin alpha-ps 0.0099 0.0835 0.1019
Echinococcus granulosus malate dehydrogenase 0.0279 0.2963 0.3637
Schistosoma mansoni cpg binding protein 0.0114 0.101 0.1233
Brugia malayi ImpB/MucB/SamB family protein 0.02 0.2034 0.2491
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0127 0.1174 0.1434
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0528 0.0602
Loa Loa (eye worm) thioredoxin reductase 0.0115 0.1022 0.1247
Loa Loa (eye worm) histone methyltransferase 0.0035 0.0082 0.0093
Leishmania major trypanothione reductase 0.0115 0.1022 0.121
Onchocerca volvulus Serine\/threonine kinase homolog 0.06 0.677 1
Toxoplasma gondii lactate dehydrogenase LDH2 0.0717 0.8148 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1309 0.1885
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 0.0401 0.0536
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0279 0.2963 0.4343
Trypanosoma cruzi polo-like protein kinase, putative 0.06 0.677 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0528 0.1381
Trichomonas vaginalis malate dehydrogenase, putative 0.0279 0.2963 0.4343
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.0528 0.0602
Echinococcus granulosus peregrin 0.0029 0.0006 0.0007
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.029 0.3103 1
Brugia malayi ImpB/MucB/SamB family protein 0.02 0.2034 0.2491
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.02 0.2034 0.2034
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0154 0.0169
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0279 0.2963 0.4343
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0139 0.0139
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0279 0.2963 0.9529
Echinococcus multilocularis L lactate dehydrogenase 0.0438 0.4851 0.4851
Brugia malayi F/Y-rich N-terminus family protein 0.0044 0.0188 0.0223
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.02 0.2034 0.2962
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1309 0.1565
Echinococcus multilocularis lactate dehydrogenase protein 0.0717 0.8148 0.8148
Onchocerca volvulus 0.0162 0.1587 0.2337
Schistosoma mansoni integrin beta subunit 0.0466 0.5178 0.6352
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.031 0.0374
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0154 0.0182
Schistosoma mansoni malate dehydrogenase 0.0279 0.2963 0.3632
Echinococcus multilocularis peregrin 0.0029 0.0006 0.0006
Trypanosoma cruzi polo-like protein kinase, putative 0.06 0.677 1
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0279 0.2963 0.4343
Toxoplasma gondii thioredoxin reductase 0.0115 0.1022 0.1247
Echinococcus granulosus malate dehydrogenase 0.0279 0.2963 0.3637
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0105 0.0911 0.1112
Loa Loa (eye worm) hypothetical protein 0.012 0.1088 0.1329
Echinococcus granulosus dna polymerase kappa 0.02 0.2034 0.2496
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0528 0.0602
Echinococcus multilocularis integrin alpha 3 0.0047 0.0227 0.0227
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0127 0.1174 0.1726
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0261 0.2758 0.8837
Echinococcus granulosus integrin alpha ps 0.0047 0.0227 0.0278
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0279 0.2963 0.4343
Schistosoma mansoni cpg binding protein 0.012 0.1086 0.1327
Mycobacterium tuberculosis Toxin MazF3 0.0133 0.1245 0.3737
Schistosoma mansoni L-lactate dehydrogenase 0.0279 0.2963 0.3632
Brugia malayi lactate dehydrogenase. 0.0717 0.8148 1
Entamoeba histolytica malate dehydrogenase, putative 0.0717 0.8148 1
Trypanosoma cruzi malate dehydrogenase, putative 0.0279 0.2963 0.4343
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0077 0.0054
Trypanosoma brucei DNA polymerase eta, putative 0.02 0.2034 0.2962
Loa Loa (eye worm) malate dehydrogenase 0.0279 0.2963 0.3632
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0077 0.0054
Leishmania major DNA polymerase kappa, putative 0.02 0.2034 0.2459
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0214 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.2034 0.2962
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0214 0.0262
Loa Loa (eye worm) glutaminase 0.028 0.2977 0.3649
Loa Loa (eye worm) hypothetical protein 0.0162 0.1587 0.1942
Trichomonas vaginalis CAMK family protein kinase 0.06 0.677 1
Mycobacterium tuberculosis Possible toxin MazF5 0.0133 0.1245 0.3737
Onchocerca volvulus 0.0094 0.0781 0.1146
Echinococcus multilocularis dna polymerase kappa 0.02 0.2034 0.2034
Brugia malayi Integrin alpha pat-2 precursor 0.0099 0.0835 0.1019
Entamoeba histolytica hypothetical protein 0.0072 0.0519 0.0591
Trypanosoma cruzi DNA polymerase kappa, putative 0.02 0.2034 0.2962
Trypanosoma brucei cytosolic malate dehydrogenase 0.0279 0.2963 0.4343
Echinococcus granulosus dna polymerase eta 0.02 0.2034 0.2496
Echinococcus granulosus jumonji domain containing protein 0.004 0.0139 0.0171
Trypanosoma cruzi DNA damage repair protein, putative 0.0062 0.0401 0.0536
Echinococcus granulosus lactate dehydrogenase a 0.0717 0.8148 1
Leishmania major glycosomal malate dehydrogenase 0.0279 0.2963 0.3605
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0035 0.0082 0.0082
Trichomonas vaginalis CAMK family protein kinase 0.06 0.677 1
Leishmania major mitochondrial malate dehydrogenase 0.0279 0.2963 0.3605
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0275 0.047
Loa Loa (eye worm) hypothetical protein 0.0047 0.0227 0.0271
Loa Loa (eye worm) hypothetical protein 0.0051 0.0275 0.033
Loa Loa (eye worm) hypothetical protein 0.0054 0.031 0.0374
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.2034 0.2962
Echinococcus multilocularis GPCR, family 2 0.0034 0.0064 0.0064
Schistosoma mansoni DNA polymerase eta 0.02 0.2034 0.2491
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0127 0.1174 0.1434
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0136 0.0142
Mycobacterium tuberculosis Possible toxin MazF4 0.0133 0.1245 0.3737
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0049 0.0053
Schistosoma mansoni hypothetical protein 0.0034 0.0064 0.0071
Giardia lamblia Malate dehydrogenase 0.0279 0.2963 0.4372
Trypanosoma cruzi DNA polymerase eta, putative 0.02 0.2034 0.2962
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0127 0.1174 0.1684
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.3137 0.4601
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.3183 0.467
Entamoeba histolytica serine/threonine protein kinase, putative 0.06 0.677 0.8301
Schistosoma mansoni hypothetical protein 0.0034 0.0064 0.0071
Mycobacterium tuberculosis Probable reductase 0.0261 0.2758 0.8837
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.004 0.0042
Schistosoma mansoni hypothetical protein 0.0338 0.3669 0.4499
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.2034 0.2962
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.031 0.0588
Leishmania major malate dehydrogenase, putative 0.0717 0.8148 1
Echinococcus granulosus cpg binding protein 0.012 0.1086 0.1333
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.2034 0.2962
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.004 0.0136 0.016
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1641 0.2378
Plasmodium falciparum DNA repair protein REV1, putative 0.0062 0.0401 0.0485
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1641 0.2378
Mycobacterium tuberculosis Possible toxin MazF7 0.0133 0.1245 0.3737
Toxoplasma gondii preprocathepsin c precursor, putative 0.0127 0.1174 0.1434
Loa Loa (eye worm) hypothetical protein 0.0073 0.0526 0.0638
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0279 0.2963 0.3632
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2675 0.3915
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0279 0.2963 0.3605
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0279 0.2963 0.4343
Echinococcus multilocularis lactate dehydrogenase a 0.0717 0.8148 0.8148
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0115 0.1022 0.2985
Schistosoma mansoni integrin alpha-ps 0.0051 0.0275 0.033
Trypanosoma brucei DNA polymerase IV, putative 0.02 0.2034 0.2962
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.036 0.3932 0.4825
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0011 0.0007
Schistosoma mansoni hypothetical protein 0.0403 0.4432 0.5437
Brugia malayi Augmenter of liver regeneration 0.0035 0.0077 0.0087
Echinococcus granulosus lactate dehydrogenase a 0.0717 0.8148 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0528 0.1381
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0279 0.2963 0.4343
Chlamydia trachomatis malate dehydrogenase 0.0279 0.2963 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0116 0.104 0.1276
Loa Loa (eye worm) integrin beta-2 0.0586 0.66 0.8099
Schistosoma mansoni malate dehydrogenase 0.0279 0.2963 0.3632
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0279 0.2963 0.9457
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.004 0.0136 0.0142
Trichomonas vaginalis malate dehydrogenase, putative 0.0279 0.2963 0.4343
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.2034 0.2962
Schistosoma mansoni hypothetical protein 0.0072 0.0519 0.0631
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0779 0.0956
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0343 0.3729 0.3729
Trypanosoma brucei DNA damage repair protein, putative 0.0062 0.0401 0.0536
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.031 0.0614
Loa Loa (eye worm) kelch domain-containing protein family protein 0.012 0.1088 0.1329
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0779 0.0779
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.3137 0.3819
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0924 0.1127
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.3137 0.4601
Trypanosoma brucei DNA polymerase kappa, putative 0.02 0.2034 0.2962
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0136 0.0118
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0006 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.02 0.2034 0.2962
Loa Loa (eye worm) hypothetical protein 0.0433 0.4791 0.5877
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.031 0.0374
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0717 0.8148 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0062 0.0401 0.0485
Toxoplasma gondii lactate dehydrogenase LDH1 0.0717 0.8148 1
Brugia malayi hypothetical protein 0.0072 0.0519 0.0631
Plasmodium falciparum glutathione reductase 0.004 0.0136 0.016
Trichomonas vaginalis malate dehydrogenase, putative 0.0279 0.2963 0.4343
Mycobacterium tuberculosis Possible toxin MazF1 0.0133 0.1245 0.3737
Leishmania major dihydrolipoamide dehydrogenase, putative 0.004 0.0136 0.0118
Plasmodium falciparum thioredoxin reductase 0.004 0.0136 0.016
Schistosoma mansoni hypothetical protein 0.0073 0.0526 0.0638
Schistosoma mansoni integrin alpha 0.0099 0.0835 0.1019
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.02 0.2034 0.2491
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0062 0.0401 0.0485
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.1299 0.187
Mycobacterium tuberculosis Conserved hypothetical protein 0.02 0.2034 0.6397
Schistosoma mansoni malate dehydrogenase 0.0717 0.8148 1
Mycobacterium tuberculosis Conserved protein 0.0133 0.1245 0.3737
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.2675 0.3915
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0279 0.2963 0.3632
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0279 0.2963 0.2963
Trichomonas vaginalis malate dehydrogenase, putative 0.0279 0.2963 0.4343
Leishmania major malate dehydrogenase, putative 0.0279 0.2963 0.3605
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1494 0.4578
Schistosoma mansoni hypothetical protein 0.0338 0.3669 0.4499
Echinococcus granulosus serine:threonine protein kinase PLK1 0.06 0.677 0.831
Echinococcus multilocularis lactate dehydrogenase a 0.0717 0.8148 0.8148
Leishmania major acetoin dehydrogenase e3 component-like protein 0.004 0.0136 0.0118
Entamoeba histolytica hypothetical protein 0.0072 0.0519 0.0591
Entamoeba histolytica hypothetical protein 0.0072 0.0519 0.0591
Echinococcus granulosus integrin beta 2 0.0586 0.66 0.81
Trichomonas vaginalis glutathione reductase, putative 0.004 0.0136 0.0142
Schistosoma mansoni hypothetical protein 0.0034 0.0064 0.0071
Toxoplasma gondii hypothetical protein 0.0047 0.0226 0.027
Echinococcus granulosus integrin alpha 3 0.0047 0.0227 0.0278
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1747 0.2536
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0279 0.2963 0.4343
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0275 0.047
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0064 0.0064
Echinococcus granulosus geminin 0.0338 0.3669 0.4503
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0214 0.0255
Trypanosoma cruzi hypothetical protein, conserved 0.0062 0.0401 0.0536
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.004 0.0136 0.0142
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0034 0.0064 0.0071
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0279 0.2963 0.3632
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.004 0.0136 0.016
Schistosoma mansoni hypothetical protein 0.0034 0.0064 0.0071
Echinococcus multilocularis expressed protein 0.0032 0.0049 0.0049
Schistosoma mansoni DNA polymerase IV / kappa 0.0062 0.0401 0.0485
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1309 0.1885
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1747 0.2536
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.0528 0.1381
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.004 0.0136 0.0136
Trypanosoma brucei unspecified product 0.0138 0.1299 0.187
Trichomonas vaginalis malate dehydrogenase, putative 0.0279 0.2963 0.4343
Echinococcus multilocularis integrin alpha ps 0.0099 0.0835 0.0835
Plasmodium falciparum thioredoxin reductase 0.0115 0.1022 0.1247
Echinococcus granulosus L lactate dehydrogenase 0.0438 0.4851 0.5954
Schistosoma mansoni hypothetical protein 0.0047 0.0227 0.0271
Trichomonas vaginalis CAMK family protein kinase 0.06 0.677 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.0911 0.1112
Trichomonas vaginalis malate dehydrogenase, putative 0.0136 0.1272 0.1831
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0214 0.0255
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0528 0.0642
Brugia malayi Trypsin family protein 0.0105 0.0911 0.1112
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0062 0.0401 0.0485
Trichomonas vaginalis CAMK family protein kinase 0.06 0.677 1
Leishmania major DNA damage repair protein, putative 0.0062 0.0401 0.0445
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.1641 0.2378
Loa Loa (eye worm) hypothetical protein 0.0717 0.8148 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0924 0.1127
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0105 0.0911 0.1112
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0343 0.3729 0.4573
Loa Loa (eye worm) hypothetical protein 0.0047 0.0227 0.0271

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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