Detailed information for compound 676472

Basic information

Technical information
  • TDR Targets ID: 676472
  • Name: methyl 4-[(3-hydroxyphenyl)methylidene]-2-met hyl-5-oxo-1H-pyrrole-3-carboxylate
  • MW: 259.257 | Formula: C14H13NO4
  • H donors: 2 H acceptors: 3 LogP: 1.36 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1=C(C)NC(=O)C1=Cc1cccc(c1)O
  • InChi: 1S/C14H13NO4/c1-8-12(14(18)19-2)11(13(17)15-8)7-9-4-3-5-10(16)6-9/h3-7,16H,1-2H3,(H,15,17)/b11-7-
  • InChiKey: LKDPFAHZBJHTHO-XFFZJAGNSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl (4Z)-4-[(3-hydroxyphenyl)methylidene]-2-methyl-5-oxo-1H-pyrrole-3-carboxylate
  • methyl (4Z)-4-[(3-hydroxyphenyl)methylene]-2-methyl-5-oxo-1H-pyrrole-3-carboxylate
  • methyl 4-[(3-hydroxyphenyl)methylene]-2-methyl-5-oxo-1H-pyrrole-3-carboxylate
  • (4Z)-4-[(3-hydroxyphenyl)methylene]-2-methyl-5-oxo-1H-pyrrole-3-carboxylic acid methyl ester
  • 4-[(3-hydroxyphenyl)methylene]-2-methyl-5-oxo-1H-pyrrole-3-carboxylic acid methyl ester
  • (4Z)-4-(3-hydroxybenzylidene)-5-keto-2-methyl-2-pyrroline-3-carboxylic acid methyl ester
  • 4-(3-hydroxybenzylidene)-5-keto-2-methyl-2-pyrroline-3-carboxylic acid methyl ester
  • STK160319
  • ZINC00312431

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.1256 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.005 0.0331 0.0938
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0402 0.1294
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0331 0.0938
Schistosoma mansoni endoplasmin 0.0038 0.0233 0.075
Onchocerca volvulus 0.0048 0.0313 0.0931
Loa Loa (eye worm) hypothetical protein 0.0107 0.0783 0.233
Giardia lamblia Pyruvate kinase 0.0032 0.0187 0.0578
Brugia malayi Nuclear hormone receptor E75 0.005 0.0331 0.0987
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0107 0.0783 0.2215
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.1244 0.3704
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1244 0.5868
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0187 0.0557
Loa Loa (eye worm) nuclear hormone receptor 0.005 0.0331 0.0987
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0056 0.038 0.1075
Plasmodium falciparum heat shock protein 90, putative 0.0144 0.1081 0.1026
Loa Loa (eye worm) glutaminase 2 0.0264 0.2046 0.609
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757
Echinococcus multilocularis pyruvate kinase 0.0032 0.0187 0.0529
Loa Loa (eye worm) hypothetical protein 0.0107 0.0783 0.233
Leishmania major pyruvate kinase 0.0032 0.0187 0.4589
Echinococcus granulosus heat shock protein 90 0.0038 0.0233 0.0659
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.0331 0.0938
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1315 0.6233
Mycobacterium ulcerans glutaminase 0.0264 0.2046 0.1894
Trypanosoma brucei heat shock protein, putative 0.0038 0.0233 1
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0149 0.0226
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0107 0.0783 0.2521
Schistosoma mansoni cpg binding protein 0.0029 0.0164 0.0529
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0107 0.0783 0.233
Brugia malayi nuclear receptor NHR-67 0.005 0.0331 0.0987
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.005 0.0331 0.0987
Brugia malayi nuclear receptor RXR 0.0056 0.038 0.113
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0233 1
Schistosoma mansoni hypothetical protein 0.0281 0.2178 0.7016
Schistosoma mansoni thyroid hormone receptor 0.0107 0.0783 0.2521
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1244 0.5868
Echinococcus multilocularis expressed protein 0.0032 0.0187 0.053
Toxoplasma gondii Hsp90 domain-containing protein 0.0144 0.1081 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.0187 0.0558
Leishmania major heat shock protein, putative 0.0025 0.0131 0.3151
Schistosoma mansoni pyruvate kinase 0.0032 0.0187 0.0602
Echinococcus granulosus tumor protein p63 0.0327 0.2552 0.7223
Trypanosoma brucei heat shock protein 84, putative 0.0025 0.0131 0.5472
Echinococcus multilocularis Protein lozenge 0.0054 0.0359 0.1016
Echinococcus multilocularis ecdysone induced protein 78C 0.0107 0.0783 0.2215
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0987
Echinococcus granulosus neuropeptide s receptor 0.045 0.3533 1
Loa Loa (eye worm) glutaminase 0.0264 0.2046 0.609
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0313 0.1007
Giardia lamblia Grp94/Hsp90 0.0036 0.0214 0.0703
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0187 0.7971
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0215 0.0208
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0187 0.0557
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1934 0.9421
Loa Loa (eye worm) inositol-1 0.0036 0.0215 0.0641
Loa Loa (eye worm) endoplasmin 0.0038 0.0233 0.0693
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0181 0.7715
Trypanosoma cruzi heat shock protein 90, putative 0.0016 0.0056 0.2159
Loa Loa (eye worm) hypothetical protein 0.0032 0.0187 0.0557
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0189 0.043
Schistosoma mansoni thyroid hormone receptor 0.0107 0.0783 0.2521
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.038 0.113
Giardia lamblia DNA repair protein RAD52 0.0288 0.2236 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0303 0.0976
Brugia malayi glutaminase DH11.1 0.0264 0.2046 0.609
Echinococcus granulosus FTZ F1 alpha 0.0107 0.0783 0.2215
Entamoeba histolytica fatty acid elongase, putative 0.0163 0.1237 0.5301
Trichomonas vaginalis heat shock protein, putative 0.0036 0.0214 0.056
Loa Loa (eye worm) hypothetical protein 0.0428 0.3359 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0189 0.0587
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0987
Trypanosoma brucei heat shock protein, putative 0.0038 0.0233 1
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0399 0.0216
Schistosoma mansoni nuclear receptor nhr-48 0.005 0.0331 0.1068
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0189 0.8051
Trichomonas vaginalis glutaminase, putative 0.0264 0.2046 1
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.1256 1 1
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757
Trichomonas vaginalis rotamase, putative 0.0032 0.0187 0.0422
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0215 0.9229
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0399 0.1129
Loa Loa (eye worm) hypothetical protein 0.0056 0.038 0.113
Plasmodium falciparum heat shock protein 90 0.0038 0.0233 0.0173
Loa Loa (eye worm) hypothetical protein 0.0107 0.0783 0.233
Plasmodium vivax heat shock protein 90, putative 0.0025 0.0131 0.007
Onchocerca volvulus Bile acid receptor homolog 0.0107 0.0783 0.233
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0187 0.0127
Schistosoma mansoni RAR-like nuclear receptor 0.0107 0.0783 0.2521
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0187 0.0557
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.1256 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0107 0.0783 0.2215
Brugia malayi Steroid receptor seven-up type 2 0.0107 0.0783 0.233
Loa Loa (eye worm) hypothetical protein 0.0107 0.0783 0.233
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757
Echinococcus multilocularis neuropeptide s receptor 0.045 0.3533 1
Trichomonas vaginalis heat shock protein, putative 0.0036 0.0214 0.056
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0399 0.0216
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0181 0.7715
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0331 0.0938
Onchocerca volvulus 0.0428 0.3359 1
Echinococcus multilocularis pyruvate kinase 0.0017 0.0061 0.0173
Echinococcus granulosus ecdysone induced protein 78C 0.0107 0.0783 0.2215
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0215 0.061
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0107 0.0783 0.233
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0107 0.0783 0.2521
Trypanosoma brucei heat shock protein, putative 0.0038 0.0233 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.038 0.113
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0107 0.0783 0.233
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0189 0.8051
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0987
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0025 0.0131 0.0103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0107 0.0783 0.233
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0187 0.0557
Brugia malayi nuclear hormone receptor family member nhr-6 0.005 0.0331 0.0987
Plasmodium falciparum pyruvate kinase 0.0032 0.0187 0.0127
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0399 0.1285
Echinococcus multilocularis heat shock protein 0.0038 0.0233 0.0659
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0082 0.0585 0.2239
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0215 0.0501
Echinococcus multilocularis tumor protein p63 0.0327 0.2552 0.7223
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757
Schistosoma mansoni glutaminase 0.0264 0.2046 0.6591
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0215 0.9229
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0187 0.0557
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0061 0.0502
Echinococcus multilocularis FTZ F1 alpha 0.0107 0.0783 0.2215
Schistosoma mansoni steroid hormone receptor ad4bp 0.0107 0.0783 0.2521
Loa Loa (eye worm) hypothetical protein 0.0022 0.0109 0.0324
Echinococcus multilocularis geminin 0.0281 0.2178 0.6165
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0107 0.0783 0.233
Echinococcus granulosus dnaJ subfamily B 0.0396 0.3104 0.8786
Onchocerca volvulus 0.005 0.0331 0.0987
Brugia malayi Inositol-1 0.0036 0.0215 0.0641
Schistosoma mansoni zinc finger protein 0.005 0.0331 0.1068
Toxoplasma gondii heat shock protein HSP90 0.0038 0.0233 0.2099
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0107 0.0783 0.233
Onchocerca volvulus 0.0059 0.0405 0.1206
Echinococcus granulosus pyruvate kinase 0.0017 0.0061 0.0173
Brugia malayi nuclear hormone receptor 0.0107 0.0783 0.233
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0107 0.0783 0.2215
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0107 0.0783 0.2521
Trypanosoma cruzi heat shock protein, putative 0.0025 0.0131 0.5472
Brugia malayi hypothetical protein 0.0428 0.3359 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0107 0.0783 0.233
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.0331 0.0987
Schistosoma mansoni nuclear receptor 0.005 0.0331 0.1068
Loa Loa (eye worm) hypothetical protein 0.0055 0.0372 0.1108
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0181 0.034
Onchocerca volvulus 0.0028 0.0152 0.0451
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.0331 0.0938
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0032 0.0189 0.0534
Echinococcus multilocularis pyruvate kinase 0.0032 0.0187 0.0529
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0215 0.0567
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0107 0.0783 0.2521
Trypanosoma brucei heat shock protein, putative 0.0038 0.0233 1
Echinococcus granulosus nuclear receptor nhr 48 0.005 0.0331 0.0938
Schistosoma mansoni nuclear receptor 0.005 0.0331 0.1068
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0025 0.0131 0.0389
Brugia malayi photoreceptor-specific nuclear receptor 0.0107 0.0783 0.233
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0987
Brugia malayi ecdysteroid receptor 0.0107 0.0783 0.233
Echinococcus multilocularis thyroid hormone receptor alpha 0.0107 0.0783 0.2215
Leishmania major pyruvate kinase 0.0032 0.0187 0.4589
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0288 0.2236 1
Brugia malayi nuclear hormone receptor 0.005 0.0331 0.0987
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0107 0.0783 0.2215
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0025 0.0131 0.037
Brugia malayi Hsp90 protein 0.0025 0.0131 0.0389
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0107 0.0783 0.2215
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1934 0.9421
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0107 0.0783 0.233
Trypanosoma brucei heat shock protein 90, putative 0.0038 0.0233 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0059 0.0405 0.1306
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0107 0.0783 0.233
Echinococcus granulosus neuropeptide receptor A26 0.045 0.3533 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0303 0.0902
Trypanosoma brucei Heat shock protein 83, putative 0.0038 0.0233 1
Echinococcus granulosus cpg binding protein 0.0029 0.0164 0.0465
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0987
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.1256 1 1
Entamoeba histolytica fatty acid elongase, putative 0.0163 0.1237 0.5301
Loa Loa (eye worm) hypothetical protein 0.0428 0.3359 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.005 0.0331 0.0938
Echinococcus multilocularis nuclear receptor nhr 48 0.005 0.0331 0.0938
Entamoeba histolytica fatty acid elongase, putative 0.0163 0.1237 0.5301
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.038 0.1223
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0987
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0187 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1934 0.9421
Loa Loa (eye worm) nuclear receptor nhr-7B 0.005 0.0331 0.0987
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0187 0.7971
Brugia malayi hypothetical protein 0.005 0.0331 0.0987
Echinococcus granulosus endoplasmin 0.0036 0.0214 0.0606
Onchocerca volvulus 0.0107 0.0783 0.233
Loa Loa (eye worm) nuclear receptor NHR-67 0.005 0.0331 0.0987
Echinococcus granulosus expressed protein 0.0032 0.0187 0.053
Loa Loa (eye worm) hypothetical protein 0.0056 0.038 0.113
Echinococcus granulosus heat shock protein 90 0.0032 0.0189 0.0534
Schistosoma mansoni nuclear hormone receptor 0.005 0.0331 0.1068
Brugia malayi heat shock protein 90 0.0038 0.0233 0.0693
Loa Loa (eye worm) hypothetical protein 0.0107 0.0783 0.233
Echinococcus granulosus geminin 0.0281 0.2178 0.6165
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0987
Brugia malayi Nuclear hormone receptor E75 0.005 0.0331 0.0987
Schistosoma mansoni rotamase 0.0032 0.0187 0.0603
Plasmodium falciparum endoplasmin, putative 0.0028 0.0149 0.0089
Onchocerca volvulus 0.0047 0.0303 0.0902
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0215 0.9229
Echinococcus multilocularis pyruvate kinase 0.0017 0.0061 0.0173
Schistosoma mansoni nuclear hormone receptor 0.005 0.0331 0.1068
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1244 0.5868
Brugia malayi Endoplasmin precursor 0.0038 0.0233 0.0693
Echinococcus multilocularis pyruvate kinase 0.0017 0.0061 0.0173
Echinococcus multilocularis heat shock protein 90 0.0032 0.0189 0.0534
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0107 0.0783 0.2521
Onchocerca volvulus 0.0059 0.0405 0.1206
Loa Loa (eye worm) heat shock protein 90 0.0038 0.0233 0.0693
Onchocerca volvulus Protein ultraspiracle homolog 0.0107 0.0783 0.233
Treponema pallidum heat shock protein 90 0.0036 0.0214 0.5
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.1256 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0107 0.0783 0.233
Plasmodium vivax endoplasmin, putative 0.0038 0.0233 0.0173
Echinococcus granulosus heat shock protein 0.0038 0.0233 0.0659
Brugia malayi nuclear receptor RXR 0.005 0.0331 0.0987
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1934 0.9421
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757
Echinococcus multilocularis endoplasmin 0.0036 0.0214 0.0606
Plasmodium vivax heat shock protein 86, putative 0.0038 0.0233 0.0173
Schistosoma mansoni cpg binding protein 0.0028 0.0152 0.0488
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0107 0.0783 0.233
Brugia malayi CXXC zinc finger family protein 0.0028 0.0152 0.0451
Echinococcus granulosus pyruvate kinase 0.0017 0.0061 0.0173
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0107 0.0783 0.2215
Brugia malayi hypothetical protein 0.0056 0.038 0.113
Schistosoma mansoni pyruvate kinase 0.0032 0.0187 0.0602
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0215 0.0567
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0399 0.1285
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0107 0.0783 0.233
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0107 0.0783 0.233
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.005 0.0331 0.0938
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0107 0.0783 0.233
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0233 1
Entamoeba histolytica heat shock protein 90, putative 0.0038 0.0233 0.0583
Echinococcus multilocularis neuropeptide receptor A26 0.045 0.3533 1
Echinococcus multilocularis heat shock protein 90 0.0038 0.0233 0.0659
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0215 0.5313
Loa Loa (eye worm) heat shock protein 75 0.0025 0.0131 0.0389
Loa Loa (eye worm) hypothetical protein 0.0056 0.038 0.113
Brugia malayi orphan nuclear receptor NR2E1 0.005 0.0331 0.0987
Trypanosoma brucei heat shock protein, putative 0.0038 0.0233 1
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0233 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0107 0.0783 0.233
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1765 0.4994
Trypanosoma brucei heat shock protein, putative 0.0038 0.0233 1
Schistosoma mansoni heat shock protein 0.0038 0.0233 0.075
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.025 0.1934 0.5756
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0233 1
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.038 0.113
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0181 0.7715
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0987
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0351 0.3201
Echinococcus granulosus pyruvate kinase 0.0032 0.0187 0.0529
Brugia malayi nuclear hormone receptor family member odr-7 0.005 0.0331 0.0987
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0036 0.0214 1
Toxoplasma gondii heat shock protein 90, putative 0.0038 0.0233 0.2099
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0056 0.038 0.1075
Loa Loa (eye worm) hypothetical protein 0.0059 0.0405 0.1206
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.005 0.0331 0.0938
Echinococcus granulosus pyruvate kinase 0.0017 0.0061 0.0173
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0215 0.1938
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0056 0.038 0.113
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0399 0.3647
Brugia malayi Nuclear hormone receptor-like 1 0.0107 0.0783 0.233
Brugia malayi hypothetical protein 0.005 0.0331 0.0987
Echinococcus granulosus pyruvate kinase 0.0032 0.0187 0.0529
Echinococcus multilocularis cpg binding protein 0.0029 0.0164 0.0465
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0987
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0107 0.0783 0.233
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0025 0.0131 0.037
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1934 0.9421
Loa Loa (eye worm) hypothetical protein 0.0229 0.1765 0.5253
Entamoeba histolytica hypothetical protein 0.0082 0.0585 0.2239
Brugia malayi ecdysone receptor 0.005 0.0331 0.0987
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.1256 1 1
Trichomonas vaginalis rotamase, putative 0.0032 0.0181 0.0391
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0181 0.162
Trypanosoma brucei heat shock protein 90, putative 0.0038 0.0233 1
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0187 0.042
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0107 0.0783 0.2215
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1244 0.5868
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0987
Brugia malayi hypothetical protein 0.0056 0.038 0.113
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0187 0.1673
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.1256 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0399 0.0218
Loa Loa (eye worm) hypothetical protein 0.0107 0.0783 0.233
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0987
Brugia malayi hypothetical protein 0.0229 0.1765 0.5253
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0107 0.0783 0.2215
Schistosoma mansoni hypothetical protein 0.0047 0.0303 0.0976
Brugia malayi tailless protein 0.005 0.0331 0.0987
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0187 0.7971
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.025 0.1934 0.5756
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0036 0.0214 0.0029
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.3104 0.8786
Schistosoma mansoni endoplasmin 0.0038 0.0233 0.075
Entamoeba histolytica heat shock protein 90, putative 0.0038 0.0233 0.0583
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0107 0.0783 0.233
Echinococcus multilocularis pyruvate kinase 0.0025 0.0133 0.0375
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1244 0.5868
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1244 0.5868
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0215 0.0029
Schistosoma mansoni inositol monophosphatase 0.0036 0.0215 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0187 0.0422
Brugia malayi steroid hormone receptor 0.0107 0.0783 0.233
Schistosoma mansoni retinoic acid receptor RXR 0.0107 0.0783 0.2521
Loa Loa (eye worm) pyruvate kinase-PB 0.0022 0.0109 0.0324
Schistosoma mansoni nuclear hormone receptor 0.0107 0.0783 0.2521
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0399 0.0216
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0107 0.0783 0.2521
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0187 0.0581
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0107 0.0783 0.233
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0036 0.0214 0.528
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0987
Loa Loa (eye worm) runx1 0.0054 0.0359 0.1069
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0036 0.0214 0.0207
Trypanosoma cruzi Heat shock protein 83, putative 0.0038 0.0233 1
Trypanosoma brucei heat shock protein, putative 0.0038 0.0233 1
Brugia malayi nuclear receptor NHR-88 0.0107 0.0783 0.233
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0233 0.0656
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0215 0.061
Brugia malayi Cation transporter family protein 0.0059 0.0405 0.1206
Schistosoma mansoni heat shock protein 0.0025 0.0131 0.0421
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0399 0.1129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0107 0.0783 0.233
Loa Loa (eye worm) hypothetical protein 0.0056 0.038 0.113
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0181 0.4442
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1934 0.9421
Mycobacterium ulcerans heat shock protein 90 0.0036 0.0214 0.0028
Entamoeba histolytica fatty acid elongase, putative 0.0163 0.1237 0.5301
Loa Loa (eye worm) hypothetical protein 0.0048 0.0313 0.0931
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1244 0.5868
Echinococcus multilocularis Nuclear hormone receptor HR96 0.005 0.0331 0.0938
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0059 0.0405 0.1306
Schistosoma mansoni coup transcription factor 0.0107 0.0783 0.2521
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.005 0.0331 0.0938
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0007 0.002
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0107 0.0783 0.2215
Brugia malayi nuclear receptor NHR-88 0.005 0.0331 0.0987
Loa Loa (eye worm) hypothetical protein 0.0059 0.0405 0.1206
Schistosoma mansoni pyruvate kinase 0.0017 0.0061 0.0197
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757
Onchocerca volvulus 0.005 0.0331 0.0987
Schistosoma mansoni hypothetical protein 0.0043 0.0272 0.0876
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1765 0.4994
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0107 0.0783 0.2215
Brugia malayi conserved hypotetical protein 0.005 0.0331 0.0987
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.005 0.0331 0.1068
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0152 0.0451
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.005 0.0331 0.0987
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0107 0.0783 0.233
Loa Loa (eye worm) hypothetical protein 0.0107 0.0783 0.233
Trichomonas vaginalis endoplasmin, putative 0.0028 0.0149 0.0226
Schistosoma mansoni inositol monophosphatase 0.0036 0.0215 0.0694
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757
Schistosoma mansoni heat shock protein 0.0038 0.0233 0.075
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0399 1
Schistosoma mansoni hypothetical protein 0.0281 0.2178 0.7016
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0233 0.0789
Schistosoma mansoni hypothetical protein 0.0396 0.3104 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0107 0.0783 0.2215
Loa Loa (eye worm) hypothetical protein 0.0107 0.0783 0.233
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0107 0.0783 0.2215
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0187 0.0557
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0187 0.042
Loa Loa (eye worm) DR-78 0.005 0.0331 0.0987
Entamoeba histolytica fatty acid elongase, putative 0.0163 0.1237 0.5301
Schistosoma mansoni cpg binding protein 0.0029 0.0164 0.0529
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0107 0.0783 0.2215
Loa Loa (eye worm) hypothetical protein 0.005 0.0331 0.0987
Plasmodium vivax heat shock protein, putative 0.0144 0.1081 0.1026
Plasmodium falciparum heat shock protein 90, putative 0.0022 0.0105 0.0044
Trypanosoma brucei heat shock protein, putative 0.0038 0.0233 1
Onchocerca volvulus 0.0059 0.0405 0.1206
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0187 0.0557
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.005 0.0331 0.1068
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0187 0.0557
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0187 0.0558
Schistosoma mansoni lozenge 0.0054 0.0359 0.1156
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1315 0.6233
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0056 0.038 0.1223
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0107 0.0783 0.233
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0215 0.0567
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0107 0.0783 0.233
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0187 0.7971
Toxoplasma gondii heat shock protein 75, putative 0.0025 0.0131 0.1149
Leishmania major heat shock protein 83-1 0.0038 0.0233 0.5757

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.