Detailed information for compound 682303

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 400.511 | Formula: C23H32N2O4
  • H donors: 1 H acceptors: 2 LogP: 2.77 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1c(C)cc(c(c1=O)C(c1ccc(cc1)OC)N1CCC(CC1)C)O
  • InChi: 1S/C23H32N2O4/c1-16-9-11-24(12-10-16)22(18-5-7-19(29-4)8-6-18)21-20(26)15-17(2)25(23(21)27)13-14-28-3/h5-8,15-16,22,26H,9-14H2,1-4H3
  • InChiKey: SYVLNQLWWGBXCZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0085 0.0962 0.0962
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0012 0.0027
Loa Loa (eye worm) hypothetical protein 0.0037 0.0261 0.0606
Mycobacterium ulcerans beta-lactamase 0.0037 0.0261 0.1155
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0174 0.2262 1
Schistosoma mansoni phosphoglycerate kinase 0.0174 0.2262 0.2262
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0045 0.0381 0.0381
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0261 0.1155
Brugia malayi PAN domain containing protein 0.0019 0.0012 0.0041
Brugia malayi PAN domain containing protein 0.0019 0.0012 0.0041
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0324 0.4444 0.8941
Schistosoma mansoni hypothetical protein 0.0085 0.0962 0.0962
Loa Loa (eye worm) hypothetical protein 0.0046 0.0395 0.0917
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.1135 0.4015
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0173 0.0394
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0016 0.0058
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.1135 0.3464
Toxoplasma gondii malate dehydrogenase MDH 0.0048 0.0426 0.1008
Echinococcus granulosus lactate dehydrogenase a 0.0048 0.0426 0.0426
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0473 0.1674
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0261 0.0925
Plasmodium vivax thioredoxin reductase, putative 0.0142 0.1796 0.7939
Mycobacterium tuberculosis Probable reductase 0.0324 0.4444 0.8941
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0261 0.0261
Entamoeba histolytica hypothetical protein 0.0037 0.0266 0.1176
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.0659 0.2913
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0032 0.0201 0.0201
Echinococcus multilocularis dna polymerase kappa 0.002 0.0016 0.0016
Brugia malayi beta-lactamase family protein 0.0037 0.0261 0.0925
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0261 0.0803
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0473 0.1098
Echinococcus granulosus dna polymerase eta 0.0046 0.0395 0.0395
Plasmodium vivax importin-beta 2, putative 0.003 0.0158 0.07
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.0445 0.1969
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0072
Toxoplasma gondii hypothetical protein 0.0049 0.0447 0.1058
Brugia malayi Pre-SET motif family protein 0.0213 0.2827 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0447 0.1036
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0197 0.0873
Mycobacterium ulcerans hypothetical protein 0.0037 0.0261 0.1155
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0174 0.2262 0.6951
Leishmania major phosphoglycerate kinase C, glycosomal 0.0174 0.2262 1
Plasmodium vivax malate dehydrogenase, putative 0.0048 0.0426 0.1883
Mycobacterium leprae Probable lipase LipE 0.0037 0.0261 0.0526
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0158 0.07
Plasmodium vivax SET domain protein, putative 0.0031 0.0173 0.0767
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0016 0.0072
Loa Loa (eye worm) hypothetical protein 0.0048 0.0426 0.0988
Mycobacterium tuberculosis Conserved protein 0.0037 0.0261 0.0526
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0016 0.0016
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0049 0.0445 0.1969
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0036 0.0255 0.0903
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0049 0.0445 0.1969
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0261 0.0526
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0016 0.0038
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0085 0.0962 0.0962
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.1135 0.5017
Echinococcus multilocularis phosphoglycerate kinase 1 0.0174 0.2262 0.2262
Echinococcus granulosus L lactate dehydrogenase B chain 0.0048 0.0426 0.0426
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0016 0.0016
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.313 0.6297
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0174 0.2262 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0077 0.0341
Echinococcus multilocularis lactate dehydrogenase protein 0.0048 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0037 0.0261 0.0606
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0425 0.1306
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0016 0.0016
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0142 0.1796 0.3614
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0016 0.0072
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.1135 0.1135
Treponema pallidum phosphoglycerate kinase 0.0174 0.2262 1
Schistosoma mansoni apoptosis regulator bax 0.0085 0.0962 0.0962
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0049 0.0445 0.0445
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0064 0.0659 0.2913
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0016 0.0072
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0016 0.0072
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1135 0.3487
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0261 0.0261
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.0445 0.1969
Entamoeba histolytica hypothetical protein 0.0037 0.0266 0.1176
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0049 0.0445 0.1969
Brugia malayi Pre-SET motif family protein 0.0031 0.0173 0.0613
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0395 0.1748
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.1135 0.2633
Toxoplasma gondii ThiF family protein 0.0032 0.0201 0.0461
Trypanosoma cruzi trypanothione reductase, putative 0.0142 0.1796 0.7939
Loa Loa (eye worm) hypothetical protein 0.0174 0.2262 0.5248
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0049 0.0445 0.1969
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1135 0.3487
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0049 0.0445 0.1969
Brugia malayi lactate dehydrogenase. 0.0048 0.0426 0.1507
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0361 0.497 1
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0048 0.0426 0.0426
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0445 0.1969
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0445 0.1969
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0012 0.0027
Onchocerca volvulus 0.0243 0.3255 1
Trypanosoma brucei phosphoglycerate kinase 0.0174 0.2262 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0049 0.0445 0.1969
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0445 0.1969
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0238 0.0841
Onchocerca volvulus 0.0037 0.0261 0.077
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0027
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0173 0.0173
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0036 0.0255 0.0903
Brugia malayi PAN domain containing protein 0.0019 0.0012 0.0041
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0361 0.497 1
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0261 0.1155
Brugia malayi Thioredoxin reductase 0.0142 0.1796 0.6353
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0049 0.0445 0.1969
Loa Loa (eye worm) ThiF family protein 0.0032 0.0201 0.0467
Echinococcus granulosus tumor protein p63 0.0344 0.4724 0.4724
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0077 0.0237
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0174 0.2262 0.5478
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0049 0.0445 0.1969
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0266 0.0266
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0261 0.0803
Echinococcus multilocularis lactate dehydrogenase a 0.0048 0.0426 0.0426
Onchocerca volvulus 0.0031 0.0173 0.0499
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0016 0.0072
Toxoplasma gondii thioredoxin reductase 0.0142 0.1796 0.4343
Loa Loa (eye worm) hypothetical protein 0.0037 0.0261 0.0606
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0049 0.0447 0.0447
Onchocerca volvulus 0.0037 0.0261 0.077
Echinococcus multilocularis thioredoxin glutathione reductase 0.0143 0.1805 0.1805
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0445 0.1969
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0049 0.0445 0.0445
Schistosoma mansoni hypothetical protein 0.0035 0.0238 0.0238
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0173 0.0173
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0174 0.2262 0.4552
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.2827 0.6558
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0049 0.0445 0.1055
Leishmania major trypanothione reductase 0.0142 0.1796 0.7939
Brugia malayi PAN domain containing protein 0.0019 0.0012 0.0041
Plasmodium falciparum thioredoxin reductase 0.0142 0.1796 0.7939
Giardia lamblia Phosphoglycerate kinase 0.0174 0.2262 1
Mycobacterium ulcerans lipase LipD 0.0037 0.0261 0.1155
Echinococcus granulosus snurportin 1 0.0315 0.4311 0.4311
Trichomonas vaginalis mercuric reductase, putative 0.0049 0.0445 0.1368
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0445 0.1969
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0077 0.0237
Schistosoma mansoni kinase 0.0049 0.0444 0.0444
Leishmania major importin beta-1 subunit, putative 0.0024 0.0077 0.0341
Echinococcus multilocularis microtubule associated protein 2 0.0707 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0261 0.0803
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0261 0.0526
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0032 0.0201 0.0889
Leishmania major DNA polymerase eta, putative 0.0032 0.0197 0.0873
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0049 0.0445 0.0445
Toxoplasma gondii PAN domain-containing protein 0.0302 0.412 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0072
Brugia malayi PAN domain containing protein 0.0019 0.0012 0.0041
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0395 0.1399
Loa Loa (eye worm) hypothetical protein 0.0037 0.0261 0.0606
Loa Loa (eye worm) hypothetical protein 0.0031 0.0173 0.0402
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0077 0.0237
Loa Loa (eye worm) hypothetical protein 0.0037 0.0261 0.0606
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0032 0.0201 0.0889
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0261 0.0261
Schistosoma mansoni cellular tumor antigen P53 0.005 0.046 0.046
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0049 0.0445 0.0896
Toxoplasma gondii lactate dehydrogenase LDH1 0.0048 0.0426 0.1008
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.1135 0.1135
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0425 0.1306
Trichomonas vaginalis set domain proteins, putative 0.0243 0.3255 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0085 0.0962 0.0962
Schistosoma mansoni DNA polymerase eta 0.0046 0.0395 0.0395
Schistosoma mansoni hypothetical protein 0.0315 0.4311 0.4311
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0261 0.0261
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.1135 0.5017
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0072
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0032 0.0201 0.0201
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0032 0.0201 0.0889
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0174 0.2262 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0027
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0261 0.1155
Trichomonas vaginalis glutathione reductase, putative 0.0049 0.0445 0.1368
Brugia malayi PAN domain containing protein 0.0019 0.0012 0.0041
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0445 0.1969
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0049 0.0445 0.1969
Plasmodium falciparum malate dehydrogenase 0.0048 0.0426 0.1883
Loa Loa (eye worm) hypothetical protein 0.0035 0.0238 0.0552
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0324 0.4444 0.8941
Loa Loa (eye worm) hypothetical protein 0.003 0.0158 0.0367
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0016 0.0072
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0324 0.4444 0.8941
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0027
Entamoeba histolytica hypothetical protein 0.0037 0.0266 0.1176
Brugia malayi PAN domain containing protein 0.0019 0.0012 0.0041
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0016 0.0072
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0261 0.0526
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0261 0.0526
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0072
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.4311 1
Brugia malayi PAN domain containing protein 0.0019 0.0012 0.0041
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1135 0.3487
Echinococcus granulosus lactate dehydrogenase a 0.0048 0.0426 0.0426
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0012 0.0027
Schistosoma mansoni hypothetical protein 0.0085 0.0962 0.0962
Echinococcus granulosus dna polymerase kappa 0.002 0.0016 0.0016
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0049 0.0447 0.0447
Brugia malayi Phosphoglycerate kinase 0.0174 0.2262 0.8003
Loa Loa (eye worm) apoptosis regulator protein 0.0085 0.0962 0.2231
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0016 0.0072
Leishmania major malate dehydrogenase, putative 0.0048 0.0426 0.1883
Mycobacterium tuberculosis Probable dehydrogenase 0.0324 0.4444 0.8941
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0049 0.0445 0.1969
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0174 0.2262 0.4552
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0174 0.2262 0.6951
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0049 0.0445 0.1575
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0016 0.0072
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0028 0.0135 0.0598
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0016 0.005
Entamoeba histolytica hypothetical protein 0.0024 0.0077 0.0341
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0072
Schistosoma mansoni malate dehydrogenase 0.0048 0.0426 0.0426
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0261 0.0526
Brugia malayi RNA, U transporter 1 0.0084 0.095 0.3359
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0072
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.0445 0.1969
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0324 0.4444 0.8941
Brugia malayi glutathione reductase 0.0142 0.1796 0.6353
Echinococcus granulosus importin subunit beta 1 0.003 0.0158 0.0158
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0261 0.1155
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0049 0.0447 0.0447
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0032 0.0201 0.0889
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0049 0.0445 0.1969
Schistosoma mansoni microtubule-associated protein tau 0.0707 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0173 0.0173
Trypanosoma brucei phosphoglycerate kinase 0.0174 0.2262 1
Entamoeba histolytica malate dehydrogenase, putative 0.0048 0.0426 0.1883
Brugia malayi ThiF family protein 0.0032 0.0201 0.0712
Giardia lamblia NADH oxidase lateral transfer candidate 0.0049 0.0445 0.1969
Loa Loa (eye worm) thioredoxin reductase 0.0142 0.1796 0.4166
Echinococcus granulosus lactate dehydrogenase protein 0.0048 0.0426 0.0426
Schistosoma mansoni importin beta-1 0.003 0.0158 0.0158
Echinococcus multilocularis tumor protein p63 0.0344 0.4724 0.4724
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0027
Giardia lamblia DINP protein human, muc B family 0.002 0.0016 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0173 0.0173
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0064 0.0659 0.2913
Plasmodium vivax glutathione reductase, putative 0.0142 0.1796 0.7939
Leishmania major DNA polymerase kappa, putative 0.002 0.0016 0.0072
Echinococcus multilocularis lactate dehydrogenase a 0.0048 0.0426 0.0426
Echinococcus multilocularis dna polymerase eta 0.0046 0.0395 0.0395
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1135 0.3487
Leishmania major DNA polymerase eta, putative 0.0046 0.0395 0.1748
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0072
Entamoeba histolytica hypothetical protein 0.0037 0.0266 0.1176
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0173 0.0173
Toxoplasma gondii NADPH-glutathione reductase 0.0049 0.0445 0.1055
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0072
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0158 0.0357
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0027
Trypanosoma brucei phosphoglycerate kinase, putative 0.0064 0.0659 0.2913
Trichomonas vaginalis esterase, putative 0.0037 0.0261 0.0803
Loa Loa (eye worm) hypothetical protein 0.0037 0.0261 0.0606
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0261 0.0803
Brugia malayi PAN domain containing protein 0.0019 0.0012 0.0041
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0261 0.0803
Toxoplasma gondii PAN domain-containing protein 0.0302 0.412 1
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0085 0.0962 0.3402
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0049 0.0445 0.0105
Brugia malayi PAN domain containing protein 0.0019 0.0012 0.0041
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0016 0.0033
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1135 0.3487
Plasmodium falciparum phosphoglycerate kinase 0.0174 0.2262 1
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0064 0.0659 0.2913
Leishmania major phosphoglycerate kinase B, cytosolic 0.0174 0.2262 1
Brugia malayi ThiF family protein 0.0049 0.0447 0.158
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0016 0.0072
Schistosoma mansoni L-lactate dehydrogenase 0.0048 0.0426 0.0426
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0473 0.1674
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0049 0.0445 0.1969
Trypanosoma brucei trypanothione reductase 0.0142 0.1796 0.7939
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0361 0.497 1
Plasmodium falciparum thioredoxin reductase 0.0049 0.0445 0.1969
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0049 0.0447 0.1974
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0049 0.0445 0.1969
Toxoplasma gondii ABC1 family protein 0.0037 0.0261 0.0608
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0027
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0395 0.1748
Echinococcus multilocularis snurportin 1 0.0315 0.4311 0.4311
Plasmodium falciparum glutathione reductase 0.0049 0.0445 0.1969
Echinococcus granulosus L lactate dehydrogenase 0.0029 0.0155 0.0155
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0012 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0072
Echinococcus multilocularis importin subunit beta 1 0.003 0.0158 0.0158
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1135 0.3487
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0173 0.0173
Schistosoma mansoni hypothetical protein 0.0085 0.0962 0.0962
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.1135 0.5017
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.0659 0.2913
Schistosoma mansoni hypothetical protein 0.0037 0.0266 0.0266
Onchocerca volvulus 0.005 0.046 0.1383
Plasmodium falciparum importin beta, putative 0.003 0.0158 0.07
Mycobacterium tuberculosis Conserved protein 0.0037 0.0261 0.0526
Entamoeba histolytica phosphoglycerate kinase, putative 0.0174 0.2262 1
Loa Loa (eye worm) glutathione reductase 0.0142 0.1796 0.4166
Brugia malayi Importin beta-1 subunit 0.003 0.0158 0.056
Trypanosoma brucei unspecified product 0.002 0.0016 0.0072
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0173 0.0173
Onchocerca volvulus 0.0037 0.0261 0.077
Plasmodium vivax lactate dehydrogenase 0.0048 0.0426 0.1883
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0158 0.07
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0157 0.0157
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0085 0.0962 0.0962
Trypanosoma brucei polo-like protein kinase 0.0097 0.1135 0.5017
Brugia malayi hypothetical protein 0.0037 0.0266 0.0942
Mycobacterium tuberculosis Probable oxidoreductase 0.0361 0.497 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.1135 0.5017
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0016 0.0072
Toxoplasma gondii lactate dehydrogenase LDH2 0.0048 0.0426 0.1008
Echinococcus granulosus thioredoxin glutathione reductase 0.0143 0.1805 0.1805
Plasmodium falciparum glutathione reductase 0.0142 0.1796 0.7939
Plasmodium vivax phosphoglycerate kinase, putative 0.0174 0.2262 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0261 0.0526
Giardia lamblia Kinase, PLK 0.0097 0.1135 0.5017
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0261 0.1155
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0049 0.0445 0.1969
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0261 0.1155
Plasmodium vivax ubiquitin activating enzyme, putative 0.0049 0.0447 0.1974
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0032 0.0201 0.0201
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0261 0.0526
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0261 0.0526
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.1135 0.1135
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0016 0.0016
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0012 0.0027
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0197 0.0452
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0049 0.0445 0.1969
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0085 0.0962 0.0962
Chlamydia trachomatis phosphoglycerate kinase 0.0174 0.2262 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0962 0.2231
Loa Loa (eye worm) hypothetical protein 0.0051 0.0473 0.1098
Echinococcus multilocularis L lactate dehydrogenase 0.0029 0.0155 0.0155
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0016 0.0072
Echinococcus multilocularis lactate dehydrogenase a 0.0048 0.0426 0.0426
Echinococcus granulosus phosphoglycerate kinase 1 0.0174 0.2262 0.2262
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0266 0.0266
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0049 0.0445 0.0105
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0261 0.0526
Loa Loa (eye worm) hypothetical protein 0.005 0.046 0.1068
Brugia malayi Phosphoglycerate kinase 0.0064 0.0659 0.2331
Leishmania major hypothetical protein, conserved 0.0037 0.0261 0.1155
Mycobacterium ulcerans phosphoglycerate kinase 0.0174 0.2262 1
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0174 0.2262 0.5478
Trypanosoma brucei phosphoglycerate kinase 0.0064 0.0659 0.2913
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.1135 0.3487
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0324 0.4444 0.8941
Brugia malayi beta-lactamase family protein 0.0037 0.0261 0.0925
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0261 0.0606
Schistosoma mansoni phosphoglycerate kinase 0.0174 0.2262 0.2262
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0016 0.0033
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0016 0.005
Plasmodium falciparum L-lactate dehydrogenase 0.0048 0.0426 0.1883
Loa Loa (eye worm) beta-lactamase 0.0037 0.0261 0.0606
Brugia malayi beta-lactamase 0.0037 0.0261 0.0925
Leishmania major ubiquitin-activating enzyme-like protein 0.0032 0.0201 0.0889
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0266 0.0266
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0064 0.0659 0.2913
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0049 0.0445 0.1969

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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