TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 451.533 | Formula: C26H30FN3O3
H donors: 1 H acceptors: 2 LogP: 3.7 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)C(c1c(O)cc(n(c1=O)CC)C)N1CCN(CC1)c1ccccc1F
InChi: 1S/C26H30FN3O3/c1-4-30-18(2)16-23(31)24(26(30)32)25(19-8-7-9-20(17-19)33-3)29-14-12-28(13-15-29)22-11-6-5-10-21(22)27/h5-11,16-17,25,31H,4,12-15H2,1-3H3
InChiKey: JSFDBKQWARFDDV-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	ran, putative	0.0021	0.0201	0.0101
Schistosoma mansoni	protein kinase	0.0035	0.0503	0.0814
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0512	0.3485
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0184	0.3661	0.5495
Trypanosoma cruzi	hexose transporter	0.0035	0.0512	0.3485
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0299	0.6102	0.7147
Echinococcus multilocularis	short transient receptor potential channel 6	0.0127	0.2471	0.4018
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0073	0.1322	0.1881
Brugia malayi	Pre-SET motif family protein	0.0413	0.8539	1
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0246	0.134
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0059	0.1023	0.1632
Leishmania major	protein kinase, putative	0.0035	0.0503	0.3409
Echinococcus multilocularis	musashi	0.0026	0.032	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0121
Entamoeba histolytica	protein kinase, putative	0.0035	0.0503	0.2692
Loa Loa (eye worm)	sugar transporter	0.0016	0.0104	0.0121
Trypanosoma cruzi	sugar transporter, putative	0.0016	0.0104	0.0194
Giardia lamblia	Prolyl-tRNA synthetase	0.0034	0.0488	1
Schistosoma mansoni	transient receptor potential channel	0.0193	0.3857	0.6316
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0246	0.0148
Leishmania major	hypothetical protein, conserved	0.0016	0.0104	0.0194
Loa Loa (eye worm)	hepatopoietin HPO2	0.0033	0.0471	0.0551
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0089	0.0094
Brugia malayi	Bromodomain containing protein	0.0037	0.0553	0.0648
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0503	0.0775
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0022	0.0222	0.1119
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0034	0.0488	0.0571
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0608	0.4254
Schistosoma mansoni	hypothetical protein	0.0015	0.0089	0.0135
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0016	0.0104	0.0155
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0035	0.0512	0.3485
Echinococcus multilocularis	lamin dm0	0.0026	0.032	0.0473
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0073	0.1322	1
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0104	0.0121
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0201	0.0099
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0104	0.0117
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0104	0.0117
Trichomonas vaginalis	set domain proteins, putative	0.047	0.9751	1
Brugia malayi	Sugar transporter family protein	0.0016	0.0104	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1286	0.1507
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0114	0.2176	0.3532
Schistosoma mansoni	protein kinase	0.0035	0.0503	0.0814
Plasmodium vivax	hypothetical protein, conserved	0.0028	0.0365	0.0264
Leishmania major	glucose transporter, lmgt3	0.0035	0.0512	0.3485
Toxoplasma gondii	lysine-tRNA ligase	0.0025	0.0303	0.0308
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0303	0.0526
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0104	0.0117
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0033	0.0471	0.0371
Schistosoma mansoni	inositol monophosphatase	0.0073	0.1322	0.2157
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0104	0.0121
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0303	0.0526
Schistosoma mansoni	transient receptor potential channel 4	0.0193	0.3857	0.6316
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0016	0.0104	0.0158
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0503	0.0775
Schistosoma mansoni	glucose transporter	0.0016	0.0104	0.0158
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0413	0.8539	1
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0072	0.1286	0.2066
Schistosoma mansoni	glucose transport protein	0.0114	0.2176	0.3559
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0114	0.2176	0.3532
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0488	0.0789
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0503	0.0775
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0358	0.0537
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0073	0.1322	0.1263
Trypanosoma cruzi	glucose transporter, putative	0.0016	0.0104	0.0194
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0512	0.3485
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0104	0.0121
Plasmodium vivax	SET domain protein, putative	0.0059	0.1023	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0121
Echinococcus granulosus	intermediate filament protein	0.0026	0.032	0.0473
Echinococcus granulosus	short transient receptor potential channel 6	0.0127	0.2471	0.4018
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0303	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0121
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0512	0.3485
Leishmania major	hypothetical protein, conserved	0.0033	0.0471	0.315
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0512	0.3485
Schistosoma mansoni	hypothetical protein	0.0114	0.2176	0.3559
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0076	0.1374	0.2243
Brugia malayi	lysyl-tRNA synthetase	0.0025	0.0303	0.0355
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.053	0.0859
Schistosoma mansoni	glucose transport protein	0.0114	0.2176	0.3559
Brugia malayi	major facilitator superfamily protein	0.0016	0.0104	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0554	0.0649
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.0608	0.4254
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0116	0.0137
Echinococcus multilocularis	jumonji domain containing protein	0.0039	0.06	0.0935
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0791	0.0926
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0121
Echinococcus granulosus	PHD finger protein rhinoceros	0.0028	0.0365	0.0547
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0016	0.0104	0.0117
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.032	0.0374
Echinococcus multilocularis	lamin	0.0026	0.032	0.0473
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0034	0.0488	0.0398
Giardia lamblia	PHD finger protein 15	0.0028	0.0365	0.6794
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0121
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0016	0.0104	0.0117
Schistosoma mansoni	hypothetical protein	0.0299	0.6102	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0488	0.0789
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0121
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.173	0.2797
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0184	0.3661	0.3595
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0034	0.0488	0.2558
Schistosoma mansoni	hypothetical protein	0.0015	0.0089	0.0135
Schistosoma mansoni	transient receptor potential channel	0.0127	0.2471	0.4043
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0033	0.0471	0.315
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0512	0.3485
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0482	1	1
Entamoeba histolytica	hypothetical protein	0.0025	0.0303	0.0905
Plasmodium falciparum	importin beta, putative	0.0028	0.0358	0.0257
Schistosoma mansoni	hypothetical protein	0.0028	0.0365	0.0587
Schistosoma mansoni	glutaminase	0.0265	0.5393	0.8836
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0028	0.0365	0.0587
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0035	0.0503	0.0404
Schistosoma mansoni	ran	0.0021	0.0201	0.0319
Trichomonas vaginalis	glutaminase, putative	0.0265	0.5393	0.5483
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0201	0.2546
Echinococcus multilocularis	lysyl tRNA synthetase	0.0025	0.0303	0.0445
Brugia malayi	Pre-SET motif family protein	0.0059	0.1023	0.1198
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0073	0.1322	0.2423
Schistosoma mansoni	sugar transporter	0.0016	0.0104	0.0158
Brugia malayi	RNA, U transporter 1	0.008	0.1453	0.1701
Brugia malayi	major facilitator superfamily protein	0.0016	0.0104	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0365	0.0427
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0089	0.0094
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0035	0.0503	0.0589
Echinococcus granulosus	inositol monophosphatase 1	0.0073	0.1322	0.2124
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0201	0.0982
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0229	0.0323
Trypanosoma brucei	glucose transporter 2A	0.0035	0.0512	0.3485
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0121
Toxoplasma gondii	protein kinase, putative	0.0321	0.6578	1
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0033	0.0471	0.0722
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0201	0.0278
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0512	0.0424
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0512	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0488	0.0571
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0033	0.0471	0.315
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0089	0.0105
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0104	0.0121
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0033	0.0471	0.315
Brugia malayi	Sugar transporter family protein	0.0016	0.0104	0.0121
Leishmania major	myo-inositol/proton symporter (MIT)	0.0016	0.0104	0.0194
Echinococcus granulosus	short transient receptor potential channel 6	0.0127	0.2471	0.4018
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0504	0.0777
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0184	0.3661	0.3595
Toxoplasma gondii	Erv1 / Alr family protein	0.0033	0.0471	0.0567
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0025	0.0303	0.1798
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0121
Leishmania major	glucose transporter, lmgt2	0.0035	0.0512	0.3485
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0059	0.1023	0.142
Echinococcus granulosus	TRP transient receptor potential channel	0.0072	0.1286	0.2066
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0503	0.0775
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0035	0.0503	0.3409
Echinococcus granulosus	lamin	0.0026	0.032	0.0473
Schistosoma mansoni	importin beta-1	0.0028	0.0358	0.0576
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0503	0.0814
Brugia malayi	PHD-finger family protein	0.0024	0.0277	0.0325
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0089	0.0094
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0706	0.1147
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0066	0.1158	1
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0066	0.1158	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0059	0.1023	0.1667
Echinococcus granulosus	calcium dependent protein kinase	0.0033	0.0457	0.07
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0026
Schistosoma mansoni	hypothetical protein	0.0033	0.0466	0.0753
Brugia malayi	Cam kinase protein 1	0.0035	0.0503	0.0589
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0035	0.0503	0.0617
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0608	0.4254
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0073	0.1322	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.115	0.1347
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0706	0.1147
Schistosoma mansoni	hypothetical protein	0.0015	0.0089	0.0135
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0246	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0503	0.0589
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0089	0.0105
Echinococcus granulosus	solute carrier family 22	0.0016	0.0104	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0121
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0201	0.0236
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0512	0.3485
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0706	0.111
Echinococcus multilocularis	peregrin	0.0031	0.0413	0.0628
Schistosoma mansoni	sugar transporter	0.0016	0.0104	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0121
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0076	0.1374	0.221
Entamoeba histolytica	protein kinase, putative	0.0035	0.0503	0.2692
Leishmania major	glucose transporter, lmgt1	0.0035	0.0512	0.3485
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0512	0.3485
Plasmodium falciparum	lysine--tRNA ligase	0.0025	0.0303	0.0201
Brugia malayi	Sugar transporter family protein	0.0114	0.2176	0.2548
Trypanosoma brucei	glucose transporter 1E	0.0035	0.0512	0.3485
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0246	0.0148
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0114	0.2176	0.3532
Loa Loa (eye worm)	hypothetical protein	0.0026	0.032	0.0374
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0104	0.0117
Schistosoma mansoni	sugar transporter	0.0016	0.0104	0.0158
Brugia malayi	Bromodomain containing protein	0.0073	0.1309	0.1533
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0201	0.0236
Schistosoma mansoni	glucose transport protein	0.0114	0.2176	0.3559
Echinococcus granulosus	transient receptor potential gamma protein	0.0193	0.3857	0.63
Echinococcus granulosus	snurportin 1	0.0299	0.6102	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0201	0.0982
Brugia malayi	intermediate filament protein	0.0026	0.032	0.0374
Plasmodium vivax	hexose transporter	0.0114	0.2176	0.2094
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0035	0.0503	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0488	0.0571
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0116	0.0178
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0034	0.0488	0.0571
Onchocerca volvulus		0.047	0.9751	1
Echinococcus multilocularis	snurportin 1	0.0299	0.6102	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.0114	0.2176	0.3201
Brugia malayi	jmjC domain containing protein	0.0093	0.173	0.2027
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0114	0.2176	0.3532
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0116	0.0178
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0089	0.0094
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0358	0.0393
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.1326	0.2165
Echinococcus granulosus	synaptic vesicle 2 protein	0.0016	0.0104	0.0117
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0706	0.1147
Loa Loa (eye worm)	glutaminase 2	0.0265	0.5393	0.6316
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.032	0.0374
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0189	0.0222
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0512	0.3485
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0035	0.0503	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0121	0.2335	0.2734
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0121
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0466	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0303	0.0355
Mycobacterium ulcerans	glutaminase	0.0265	0.5393	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0035	0.0503	0.0775
Schistosoma mansoni	zinc finger protein	0.0015	0.0079	0.0119
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.053	0.0621
Brugia malayi	Bromodomain containing protein	0.0031	0.0413	0.0484
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0073	0.1322	0.1263
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0512	0.3485
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0121
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0076	0.1374	0.2243
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0058	0.0994	0.1584
Trypanosoma brucei	sugar transporter, putative	0.0016	0.0104	0.0194
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0358	0.0537
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0089	0.0094
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0512	0.0424
Loa Loa (eye worm)	inositol-1	0.0073	0.1322	0.1548
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0073	0.1322	1
Brugia malayi	glutaminase DH11.1	0.0265	0.5393	0.6316
Echinococcus granulosus	zinc finger protein	0.0019	0.0168	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0022	0.0026
Brugia malayi	Inositol-1	0.0073	0.1322	0.1548
Giardia lamblia	Lysyl-tRNA synthetase	0.0025	0.0303	0.5182
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0512	0.3485
Toxoplasma gondii	Erv1 / Alr family protein	0.0033	0.0471	0.0567
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0062	0.0073
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0512	0.0424
Echinococcus granulosus	peregrin	0.0031	0.0413	0.0628
Plasmodium falciparum	phd finger protein, putative	0.0028	0.0365	0.0264
Plasmodium falciparum	proline--tRNA ligase	0.004	0.0608	0.051
Brugia malayi	F/Y-rich N-terminus family protein	0.0013	0.0046	0.0054
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0512	0.3485
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.0365	0.0403
Echinococcus granulosus	lysyl tRNA synthetase	0.0025	0.0303	0.0445
Plasmodium falciparum	protein kinase 7	0.0321	0.6578	0.6542
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0114	0.2176	0.3532
Echinococcus granulosus	solute carrier family 22	0.0016	0.0104	0.0117
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0016	0.0104	0.0194
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0057	0.0977	0.1556
Loa Loa (eye worm)	hypothetical protein	0.0026	0.031	0.0363
Schistosoma mansoni	hypothetical protein	0.002	0.0189	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3857	0.4516
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0201	0.0278
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0246	0.134
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0303	0.0485
Echinococcus multilocularis	transient receptor potential gamma protein	0.0193	0.3857	0.63
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0201	0.0151
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0114	0.2176	0.3532
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0512	0.3485
Plasmodium vivax	proline--tRNA ligase, putative	0.004	0.0608	0.051
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0706	0.0827
Loa Loa (eye worm)	hypothetical protein	0.004	0.0603	0.0706
Echinococcus granulosus	lamin dm0	0.0026	0.032	0.0473
Brugia malayi	hypothetical protein	0.0016	0.0104	0.0121
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0512	0.3485
Brugia malayi	hypothetical protein	0.0016	0.0104	0.0121
Echinococcus granulosus	solute carrier family 22	0.0016	0.0104	0.0117
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0358	0.2244
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0025	0.0303	0.0866
Echinococcus granulosus	solute carrier family 22	0.0016	0.0104	0.0117
Schistosoma mansoni	transient receptor potential channel	0.0127	0.2471	0.4043
Echinococcus multilocularis	calcium dependent protein kinase	0.0033	0.0457	0.07
Schistosoma mansoni	sugar transporter	0.0016	0.0104	0.0158
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0503	0.0775
Brugia malayi	Importin beta-1 subunit	0.0028	0.0358	0.0419
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0035	0.0503	0.0404
Echinococcus multilocularis	zinc finger protein	0.0019	0.0168	0.0223
Trichomonas vaginalis	inositol monophosphatase, putative	0.0073	0.1322	0.1263
Trypanosoma cruzi	hexose transporter, putative	0.0016	0.0104	0.0194
Echinococcus multilocularis	transient receptor potential ion channel A	0.0186	0.372	0.6075
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0089	0.0105
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0016	0.0104	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0069	0.1221	0.1429
Schistosoma mansoni	bromodomain containing protein	0.0061	0.1067	0.174
Treponema pallidum	prolyl-tRNA synthetase	0.0012	0.002	0.5
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0016	0.0104	0.0117
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0706	0.111
Onchocerca volvulus		0.0059	0.1023	0.0953
Mycobacterium ulcerans	sugar transporter	0.0016	0.0104	0.0155
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.1004	0.1176
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0706	0.111
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0058	0.0994	0.1584
Schistosoma mansoni	inositol monophosphatase	0.0073	0.1322	0.2157
Echinococcus granulosus	histone lysine methyltransferase setb	0.0076	0.1374	0.221
Echinococcus multilocularis	short transient receptor potential channel 6	0.0127	0.2471	0.4018
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0201	0.0099
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0201	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0121
Echinococcus granulosus	jumonji domain containing protein	0.0039	0.06	0.0935
Schistosoma mansoni	lamin	0.0026	0.032	0.0513
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0128	0.015
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.004	0.0608	0.0779
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0025	0.0303	0.0206
Schistosoma mansoni	intermediate filament proteins	0.0026	0.032	0.0513
Loa Loa (eye worm)	sugar transporter	0.0114	0.2176	0.2548
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0033	0.0471	0.315
Schistosoma mansoni	zinc finger protein	0.0019	0.0168	0.0263
Loa Loa (eye worm)	PHD-finger family protein	0.0028	0.0365	0.0427
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.2176	0.2148
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0608	0.4254
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0035	0.0503	0.0404
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0488	0.075
Chlamydia trachomatis	lysine--tRNA ligase	0.0025	0.0303	1
Brugia malayi	PHD-finger family protein	0.0028	0.0365	0.0427
Schistosoma mansoni	hypothetical protein	0.0015	0.0089	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0643	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1374	0.1609
Echinococcus multilocularis	inositol monophosphatase 1	0.0073	0.1322	0.2124
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0035	0.0503	0.0617
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0034	0.0488	0.2843
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0512	0.0424
Brugia malayi	hypothetical protein	0.0016	0.0104	0.0121
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0503	0.0775
Onchocerca volvulus		0.0026	0.032	0.0224
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.053	0.082
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0504	0.0777
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0033	0.0471	0.0722
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0073	0.1322	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0114	0.2176	0.3532
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0121
Echinococcus granulosus	transient receptor potential ion channel A	0.0186	0.372	0.6075
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0035	0.0503	0.0404
Plasmodium falciparum	hexose transporter	0.0114	0.2176	0.2094
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0706	0.111
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0229	0.0323
Echinococcus granulosus	General substrate transporter	0.0098	0.1837	0.2973
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0028	0.0365	0.0547
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.173	0.2797
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0035	0.0503	0.0404
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0025	0.0303	0.1798
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0032	0.0038
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0229	0.0364
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0491	0.0756
Leishmania major	lysyl-tRNA synthetase, putative	0.0025	0.0303	0.1798
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0358	0.0257
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.053	0.0859
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.032	0.0374
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0035	0.0503	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0358	0.0419
Echinococcus multilocularis	General substrate transporter	0.0098	0.1837	0.2973
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0352	0.0413
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0089	0.0105
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.0173	0.0755
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0104	0.0121
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.0608	0.4254
Brugia malayi	jmjC domain containing protein	0.0036	0.053	0.0621
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0503	0.0775
Leishmania major	GTP-binding protein, putative	0.0021	0.0201	0.0982
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0236	0.0138
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.0365	0.0403
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0791	0.0926
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0466	0.0546
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0512	0.0424
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0706	0.0827
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0062	0.0073
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0059	0.1023	0.1667
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0035	0.0503	0.0404
Echinococcus granulosus	GPCR family 2	0.0015	0.0089	0.0094
Plasmodium vivax	lysine--tRNA ligase, putative	0.0025	0.0303	0.0201
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0791	0.0926
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0104	0.0121
Entamoeba histolytica	hypothetical protein	0.0023	0.0246	0.0397
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0791	0.0926
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0035	0.0503	0.0404
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0035	0.0503	0.0589
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0033	0.0471	0.0371
Schistosoma mansoni	protein kinase	0.0035	0.0503	0.0814
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0488	0.075
Onchocerca volvulus	Alhambra homolog	0.0028	0.0365	0.0271
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0512	0.3485
Loa Loa (eye worm)	glutaminase	0.0265	0.5393	0.6316
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0073	0.1322	1
Brugia malayi	Transient-receptor-potential like protein	0.0072	0.1286	0.1507
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0022	0.0222	0.1119
Schistosoma mansoni	hypothetical protein	0.0015	0.0079	0.0119
Onchocerca volvulus		0.0026	0.032	0.0224
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0014	0.0061	0.0072
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0073	0.1322	1
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0116	0.0137
Schistosoma mansoni	ran	0.0021	0.0201	0.0319
Trichomonas vaginalis	CAMK family protein kinase	0.0035	0.0503	0.0414
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0358	0.2244
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0114	0.2176	0.3532
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0512	0.0424
Brugia malayi	Augmenter of liver regeneration	0.0033	0.0471	0.0551
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0035	0.0503	0.0589
Mycobacterium ulcerans	integral membrane transport protein	0.0016	0.0104	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0794	0.0929
Schistosoma mansoni	lamin	0.0026	0.032	0.0513

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 682334