Detailed information for compound 686859

Basic information

Technical information
  • TDR Targets ID: 686859
  • Name: 4-chloro-N-[2-fluoro-5-(2-methyl-4-oxoquinazo lin-3-yl)phenyl]benzamide
  • MW: 407.825 | Formula: C22H15ClFN3O2
  • H donors: 1 H acceptors: 2 LogP: 4 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(=O)Nc1cc(ccc1F)n1c(C)nc2c(c1=O)cccc2
  • InChi: 1S/C22H15ClFN3O2/c1-13-25-19-5-3-2-4-17(19)22(29)27(13)16-10-11-18(24)20(12-16)26-21(28)14-6-8-15(23)9-7-14/h2-12H,1H3,(H,26,28)
  • InChiKey: MTAFWWKYMVWJGF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chloro-N-[2-fluoro-5-(2-methyl-4-oxo-quinazolin-3-yl)phenyl]benzamide
  • 4-chloro-N-[2-fluoro-5-(2-methyl-4-oxo-3-quinazolinyl)phenyl]benzamide
  • 4-chloro-N-[2-fluoro-5-(4-keto-2-methyl-quinazolin-3-yl)phenyl]benzamide
  • ZINC05259077

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0458 0.0764
Echinococcus multilocularis lamin 0.0083 0.1546 0.1821
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0248 0.0292
Brugia malayi Sugar transporter family protein 0.0015 0.0048 0.0061
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0049 0.0794 0.0751
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.2036 0.2001
Loa Loa (eye worm) hypothetical protein 0.0145 0.2921 0.3442
Echinococcus granulosus geminin 0.0351 0.7494 0.8831
Schistosoma mansoni glucose transporter 0.0015 0.0048 0.0056
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0458 0.225
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0403 0.0475
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0048 0.008
Echinococcus multilocularis muscleblind protein 0.0145 0.2921 0.3442
Echinococcus multilocularis GPCR, family 2 0.0115 0.2257 0.266
Onchocerca volvulus 0.0015 0.0048 0.015
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0595 0.0701
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.0252 0.0206
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0252 0.0325
Echinococcus multilocularis geminin 0.0351 0.7494 0.8831
Echinococcus granulosus lamin dm0 0.0083 0.1546 0.1821
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.0252 0.042
Echinococcus multilocularis SPRY domain containing protein 0.0016 0.0063 0.0074
Loa Loa (eye worm) hypothetical protein 0.0038 0.0561 0.0661
Echinococcus granulosus ryanodine receptor 44f 0.0013 0 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1318 0.2199
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0122 0.0075
Trypanosoma brucei unspecified product 0.0019 0.0122 0.0601
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.5995 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0449 0.0404
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0049 0.0794 0.39
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0458 0.1496
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.0252 0.0385
Schistosoma mansoni hypothetical protein 0.0047 0.0752 0.0886
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0449 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Loa Loa (eye worm) hypothetical protein 0.0363 0.7766 0.9151
Loa Loa (eye worm) hypothetical protein 0.0073 0.1318 0.1553
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0122 0.0204
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0181 0.0302
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0458 0.059
Schistosoma mansoni protein kinase 0.0033 0.0449 0.0529
Brugia malayi Muscleblind-like protein 0.0145 0.2921 0.3761
Echinococcus multilocularis short transient receptor potential channel 6 0.0262 0.5514 0.6497
Trypanosoma brucei glucose transporter, putative 0.0034 0.0458 0.225
Giardia lamblia DNA repair protein RAD52 0.0337 0.7186 1
Echinococcus granulosus transient receptor potential ion channel A 0.0382 0.8194 0.9655
Leishmania major glucose transporter/membrane transporter D2, putative 0.0034 0.0458 0.225
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0601
Chlamydia trachomatis thioredoxin reductase 0.0139 0.2791 1
Loa Loa (eye worm) sugar transporter 0.0109 0.2128 0.2508
Onchocerca volvulus 0.0015 0.0048 0.015
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0109 0.2128 0.2508
Onchocerca volvulus 0.0015 0.0048 0.015
Schistosoma mansoni sugar transporter 0.0015 0.0048 0.0056
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0449 0.0578
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.0252 0.0265
Trypanosoma brucei sugar transporter, putative 0.0015 0.0048 0.0234
Leishmania major hypothetical protein, conserved 0.0015 0.0048 0.0234
Echinococcus multilocularis pyruvate kinase 0.0027 0.03 0.0353
Echinococcus granulosus GPCR family 2 0.0115 0.2257 0.266
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0248 0.0729
Echinococcus multilocularis pyruvate kinase 0.0034 0.0458 0.054
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0449 0.2204
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.1318 0.1553
Echinococcus multilocularis dna repair and recombination protein rad54 0.0016 0.0063 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1318 0.6475
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0109 0.2128 0.2508
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0048 0.008
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.2036 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0056
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0403 0.0475
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0449 0.0404
Loa Loa (eye worm) hypothetical protein 0.0033 0.0434 0.0511
Echinococcus multilocularis tumor protein p63 0.0349 0.7456 0.8785
Toxoplasma gondii protein kinase, putative 0.0308 0.6548 1
Giardia lamblia Pyruvate kinase 0.0034 0.0458 0.0575
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0048 0.0056
Brugia malayi Sugar transporter family protein 0.0109 0.2128 0.2741
Loa Loa (eye worm) hypothetical protein 0.0038 0.0561 0.0661
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0248 0.031
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1323 0.1559
Loa Loa (eye worm) hypothetical protein 0.0034 0.0458 0.054
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0048 0.0056
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0692 0.0891
Echinococcus multilocularis General substrate transporter 0.0094 0.1788 0.2107
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0093 0.0141
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0554 0.0846
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0048 0.0234
Echinococcus multilocularis solute carrier family 22 0.0015 0.0048 0.0056
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0056
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0601
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0248 0.0319
Mycobacterium leprae conserved hypothetical protein 0.0073 0.1318 0.4389
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0458 0.07
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0458 0.0764
Schistosoma mansoni transient receptor potential channel 0.0262 0.5514 0.6497
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.1318 0.1277
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0458 0.225
Schistosoma mansoni hypothetical protein 0.0109 0.2128 0.2508
Plasmodium falciparum mitogen-activated protein kinase 2 0.0176 0.362 0.3595
Onchocerca volvulus 0.0073 0.1318 0.4138
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0122 0.0601
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1724 0.2032
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.1546 0.199
Loa Loa (eye worm) hypothetical protein 0.0147 0.2972 0.3503
Loa Loa (eye worm) beta-lactamase 0.0073 0.1318 0.1553
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Loa Loa (eye worm) hypothetical protein 0.0105 0.2036 0.2399
Loa Loa (eye worm) hypothetical protein 0.0073 0.1318 0.1553
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0093 0.0045
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0458 0.0764
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0252 0.0297
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Giardia lamblia DINP protein human, muc B family 0.0019 0.0122 0.0105
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0075
Schistosoma mansoni sugar transporter 0.0015 0.0048 0.0056
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0554 0.2721
Loa Loa (eye worm) hypothetical protein 0.0051 0.0841 0.0991
Entamoeba histolytica protein kinase, putative 0.0033 0.0449 0.0541
Brugia malayi hypothetical protein 0.0037 0.0529 0.0681
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0013 0 0.0001
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0458 0.0764
Brugia malayi hypothetical protein 0.0015 0.0048 0.0061
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0056
Echinococcus granulosus DNA repair and recombination protein RAD54B 0.0016 0.0063 0.0075
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.0252 0.1238
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0248 0.0201
Echinococcus granulosus dna repair and recombination protein rad54 0.0016 0.0063 0.0075
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0122 0.0601
Echinococcus multilocularis solute carrier family 22 0.0015 0.0048 0.0056
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0231 0.0272
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0458 0.225
Loa Loa (eye worm) hypothetical protein 0.0248 0.5216 0.6147
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0049 0.0794 0.39
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative 0.0016 0.0063 0.0311
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.2434 0.2868
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Plasmodium vivax hexose transporter 0.0109 0.2128 0.2094
Leishmania major glucose transporter, lmgt3 0.0034 0.0458 0.225
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0231 0.0235
Echinococcus granulosus dna polymerase kappa 0.0019 0.0122 0.0144
Mycobacterium ulcerans beta-lactamase 0.0073 0.1318 0.4632
Schistosoma mansoni intermediate filament proteins 0.0083 0.1546 0.1821
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0794 0.0936
Schistosoma mansoni lamin 0.0083 0.1546 0.1821
Brugia malayi Latrophilin receptor protein 2 0.0115 0.2257 0.2906
Brugia malayi hypothetical protein 0.0015 0.0048 0.0061
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0248 0.1217
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0252 0.0325
Echinococcus granulosus solute carrier family 22 0.0015 0.0048 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1724 0.2032
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0109 0.2128 0.2508
Echinococcus multilocularis 0.0016 0.0063 0.0075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1724 0.2032
Schistosoma mansoni glucose transport protein 0.0109 0.2128 0.2508
Loa Loa (eye worm) T-complex protein 1 0.0025 0.0252 0.0297
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0048 0.008
Trypanosoma brucei glucose transporter, putative 0.0034 0.0458 0.225
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0122 0.0144
Leishmania major hypothetical protein, conserved 0.0105 0.2036 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1724 0.2032
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0122 0.0144
Loa Loa (eye worm) hypothetical protein 0.0019 0.0122 0.0144
Onchocerca volvulus 0.0083 0.1546 0.4851
Echinococcus multilocularis pyruvate kinase 0.0017 0.0093 0.0109
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0048 0.008
Echinococcus multilocularis solute carrier family 22 0.0015 0.0048 0.0056
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0449 0.0529
Schistosoma mansoni protein kinase 0.0033 0.0449 0.0529
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.2434 0.2868
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0601
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0005 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0048 0.008
Onchocerca volvulus 0.0015 0.0048 0.015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0056
Loa Loa (eye worm) hypothetical protein 0.0027 0.0297 0.035
Entamoeba histolytica thioredoxin reductase, putative 0.0139 0.2791 0.383
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0601
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0449 0.0404
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0096 0.1835 0.2488
Leishmania major glucose transporter, lmgt1 0.0034 0.0458 0.225
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.1318 0.1697
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.0252 0.0206
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0033 0.0434 0.052
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0048 0.0234
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0434 0.0511
Echinococcus granulosus solute carrier family 22 0.0015 0.0048 0.0056
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0449 0.0529
Brugia malayi TAR-binding protein 0.0073 0.1323 0.1704
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0458 0.1438
Onchocerca volvulus 0.0015 0.0048 0.015
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0248 0.0292
Trichomonas vaginalis glucose transporter, putative 0.0034 0.0458 0.0764
Schistosoma mansoni transient receptor potential channel 4 0.0395 0.8487 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0115 0.2257 0.266
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.1318 0.4632
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0048 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.1318 0.6475
Brugia malayi Calcitonin receptor-like protein seb-1 0.0363 0.7766 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0248 0.1217
Trypanosoma cruzi PAB1-binding protein , putative 0.0105 0.2036 1
Echinococcus multilocularis 0.0016 0.0063 0.0074
Brugia malayi Transient-receptor-potential like protein 0.0147 0.2972 0.3827
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Echinococcus granulosus short transient receptor potential channel 6 0.0262 0.5514 0.6497
Brugia malayi RNA binding protein 0.0073 0.1323 0.1704
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0449 0.0529
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0122 0.0144
Onchocerca volvulus 0.0073 0.1318 0.4138
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0056
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0449 0.0529
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Entamoeba histolytica hypothetical protein 0.0037 0.0529 0.0654
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.5995 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0056
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.1724 0.2032
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0554 0.051
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0139 0.2791 1
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0449 0.0404
Mycobacterium tuberculosis Conserved protein 0.0073 0.1318 0.1277
Leishmania major DNA repair and recombination protein RAD54, putative 0.0016 0.0063 0.0311
Schistosoma mansoni transient receptor potential channel 0.0395 0.8487 1
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.4932 0.5811
Onchocerca volvulus 0.0015 0.0048 0.015
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.1318 0.1277
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0449 0.0529
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0048 0.008
Brugia malayi major facilitator superfamily protein 0.0015 0.0048 0.0061
Schistosoma mansoni ryanodine receptor related 0.0013 0 0.0001
Schistosoma mansoni protein kinase 0.0033 0.0449 0.0529
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0458 0.054
Schistosoma mansoni pyruvate kinase 0.0017 0.0093 0.0109
Chlamydia trachomatis pyruvate kinase 0.0034 0.0458 0.0827
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0122 0.0601
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0139 0.2791 0.4656
Trypanosoma brucei glucose transporter, putative 0.0034 0.0458 0.225
Mycobacterium ulcerans hypothetical protein 0.0073 0.1318 0.4632
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0122 0.0075
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0049 0.0794 0.0751
Trichomonas vaginalis esterase, putative 0.0073 0.1318 0.2199
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0449 0.0529
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0122 0.0144
Schistosoma mansoni lamin 0.0083 0.1546 0.1821
Leishmania major DNA polymerase kappa, putative 0.0019 0.0122 0.0601
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0458 0.1438
Leishmania major protein kinase, putative 0.0033 0.0449 0.2204
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0139 0.2791 1
Onchocerca volvulus Putative transporter 0.0015 0.0048 0.015
Plasmodium vivax DNA repair protein RAD54, putative 0.0016 0.0063 0.0016
Loa Loa (eye worm) isocitrate dehydrogenase 0.0049 0.0794 0.0936
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.1318 0.1553
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0056
Schistosoma mansoni hypothetical protein 0.0351 0.7494 0.8831
Trypanosoma brucei glucose transporter, putative 0.0034 0.0458 0.225
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0252 0.0297
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1323 0.1559
Trypanosoma brucei DNA repair and recombination protein RAD54, putative 0.0016 0.0063 0.0311
Plasmodium falciparum protein kinase 6 0.0463 0.9983 1
Trichomonas vaginalis sugar transporter, putative 0.0034 0.0458 0.0764
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0248 0.0413
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0049 0.0794 0.0936
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0363 0.7766 1
Leishmania major hypothetical protein, conserved 0.0073 0.1318 0.6475
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.5995 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0434 0.0511
Schistosoma mansoni survival motor neuron protein 0.0048 0.0773 0.0911
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0056
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0554 0.2721
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0601
Onchocerca volvulus 0.0048 0.0773 0.2426
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0449 0.0404
Brugia malayi hypothetical protein 0.0105 0.2036 0.2622
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0122 0.0601
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0056
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0449 0.0529
Loa Loa (eye worm) sugar transporter 0.0015 0.0048 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1318 0.2199
Echinococcus granulosus intermediate filament protein 0.0083 0.1546 0.1821
Brugia malayi beta-lactamase family protein 0.0073 0.1318 0.1697
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.1318 0.1277
Brugia malayi hypothetical protein 0.0235 0.4932 0.635
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0056
Echinococcus multilocularis dna polymerase eta 0.0019 0.0122 0.0144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.1724 0.2032
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.0252 0.0286
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0458 0.225
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0794 0.1213
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0794 0.0936
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0601
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.1323 0.1704
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0048 0.0061
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0139 0.2791 0.4656
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0115 0.2257 0.2906
Echinococcus multilocularis tar DNA binding protein 0.0073 0.1323 0.1559
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1323 0.1559
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0458 0.225
Schistosoma mansoni sugar transporter 0.0015 0.0048 0.0056
Schistosoma mansoni hypothetical protein 0.0115 0.2257 0.266
Mycobacterium tuberculosis Conserved protein 0.0073 0.1318 0.1277
Entamoeba histolytica protein kinase, putative 0.0033 0.0449 0.0541
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1318 0.1553
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.1318 0.1553
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0529 0.0623
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0248 0.0292
Entamoeba histolytica hypothetical protein 0.0024 0.0248 0.0259
Leishmania major DNA polymerase eta, putative 0.0019 0.0122 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0048 0.008
Giardia lamblia Thioredoxin reductase 0.0139 0.2791 0.3843
Echinococcus granulosus SPRY domain containing protein 0.0016 0.0063 0.0074
Loa Loa (eye worm) hypothetical protein 0.0073 0.1318 0.1553
Onchocerca volvulus 0.0015 0.0048 0.015
Echinococcus multilocularis musashi 0.0083 0.1546 0.1821
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0794 0.1213
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0139 0.2791 0.4656
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0122 0.0083
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0248 0.0378
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0122 0.0601
Loa Loa (eye worm) intermediate filament protein 0.0083 0.1546 0.1821
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0248 0.0292
Echinococcus multilocularis dna repair and recombination protein rad54 0.0016 0.0063 0.0074
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0122 0.0204
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0074
Echinococcus granulosus General substrate transporter 0.0094 0.1788 0.2107
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0139 0.2791 0.4656
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0794 0.0936
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1318 0.2199
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Brugia malayi recombination factor GdRad54 0.0016 0.0063 0.0082
Trypanosoma cruzi hexose transporter 0.0034 0.0458 0.225
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.1724 0.2032
Brugia malayi major facilitator superfamily protein 0.0015 0.0048 0.0061
Loa Loa (eye worm) hypothetical protein 0.0145 0.2921 0.3442
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0109 0.2128 0.2508
Echinococcus granulosus pyruvate kinase 0.0017 0.0093 0.0109
Loa Loa (eye worm) hypothetical protein 0.0073 0.1318 0.1553
Echinococcus granulosus pyruvate kinase 0.0034 0.0458 0.054
Echinococcus multilocularis transient receptor potential ion channel A 0.0382 0.8194 0.9655
Plasmodium vivax CDK-related protein kinase 6, putative 0.0463 0.9983 1
Schistosoma mansoni hypothetical protein 0.0248 0.5216 0.6147
Onchocerca volvulus 0.0157 0.3186 1
Loa Loa (eye worm) hypothetical protein 0.0248 0.5222 0.6153
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0601
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0554 0.2721
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0033 0.0434 0.0511
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0554 0.2721
Onchocerca volvulus 0.0073 0.1318 0.4138
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0265 0.5585 0.6581
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0109 0.2128 0.2508
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0122 0.0601
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0048 0.0234
Echinococcus granulosus muscleblind protein 0.0145 0.2921 0.3442
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.5995 0.8331
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0122 0.0272
Trypanosoma brucei glucose transporter 2A 0.0034 0.0458 0.225
Echinococcus multilocularis ryanodine receptor 44f 0.0013 0 0.0001
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0449 0.0529
Schistosoma mansoni hypothetical protein 0.0115 0.2257 0.266
Loa Loa (eye worm) latrophilin receptor protein 2 0.0115 0.2257 0.266
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0048 0.0056
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0458 0.225
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0139 0.2791 1
Plasmodium falciparum protein kinase 7 0.0308 0.6548 0.6542
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0115 0.2257 0.266
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0449 0.0686
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.5995 1
Echinococcus granulosus lamin 0.0083 0.1546 0.1821
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0122 0.0272
Loa Loa (eye worm) hypothetical protein 0.0033 0.0449 0.0529
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0794 0.39
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0529 0.0623
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.1318 0.1277
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0248 0.0201
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0794 0.39
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0458 0.059
Trypanosoma brucei glucose transporter 1E 0.0034 0.0458 0.225
Schistosoma mansoni sugar transporter 0.0015 0.0048 0.0056
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0458 0.225
Echinococcus granulosus calcium activated potassium channel 0.0015 0.0046 0.0055
Trypanosoma brucei glucose transporter, putative 0.0034 0.0458 0.225
Loa Loa (eye worm) hypothetical protein 0.0235 0.4932 0.5811
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.1318 0.1553
Plasmodium falciparum hexose transporter 0.0109 0.2128 0.2094
Echinococcus granulosus transient receptor potential gamma protein 0.0395 0.8487 1
Brugia malayi latrophilin 2 splice variant baaae 0.0248 0.5216 0.6717
Echinococcus granulosus SPRY domain containing protein 0.0016 0.0063 0.0074
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0033 0.0434 0.0723
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0449 0.0686
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.0016 0.0063 0.0075
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Schistosoma mansoni hypothetical protein 0.0048 0.0773 0.0911
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Onchocerca volvulus 0.0015 0.0048 0.015
Mycobacterium ulcerans lipase LipD 0.0073 0.1318 0.4632
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0093 0.0045
Schistosoma mansoni hypothetical protein 0.0037 0.0529 0.0623
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0176 0.362 0.3595
Loa Loa (eye worm) hypothetical protein 0.004 0.0595 0.0701
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.1318 0.4632
Echinococcus granulosus dna polymerase eta 0.0019 0.0122 0.0144
Brugia malayi hypothetical protein 0.0157 0.3186 0.4103
Echinococcus multilocularis isocitrate dehydrogenase 0.0049 0.0794 0.0936
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0458 0.0764
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative 0.0016 0.0063 0.0311
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0033 0.0434 0.0511
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.5995 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0176 0.362 0.5528
Schistosoma mansoni DNA polymerase eta 0.0019 0.0122 0.0144
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1323 0.1559
Brugia malayi beta-lactamase family protein 0.0073 0.1318 0.1697
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0458 0.0413
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0554 0.2721
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.2779 0.9953
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0049 0.0794 0.0936
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0109 0.2128 0.2508
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0139 0.2791 0.4656
Trypanosoma cruzi hexose transporter, putative 0.0034 0.0458 0.225
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.0752 0.0886
Echinococcus granulosus short transient receptor potential channel 6 0.0262 0.5514 0.6497
Mycobacterium tuberculosis Conserved protein 0.0073 0.1318 0.1277
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0049 0.0794 0.0936
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0048 0.0061
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.5995 1
Leishmania major glucose transporter, lmgt2 0.0034 0.0458 0.225
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0601
Trypanosoma brucei PAB1-binding protein , putative 0.0105 0.2036 1
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0016 0.0063 0.0082
Plasmodium falciparum pyruvate kinase 0.0034 0.0458 0.0413
Plasmodium falciparum ataxin-2 like protein, putative 0.0105 0.2036 0.2001
Toxoplasma gondii sugar transporter ST3 0.0015 0.0048 0.0073
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0075
Plasmodium vivax hypothetical protein, conserved 0.0073 0.1318 0.1279
Onchocerca volvulus 0.0015 0.0048 0.015
Echinococcus granulosus tar DNA binding protein 0.0073 0.1323 0.1559
Toxoplasma gondii facilitative glucose transporter GT1 0.0109 0.2128 0.3251
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0529 0.0623
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0554 0.051
Echinococcus multilocularis muscleblind protein 1 0.0145 0.2921 0.3442
Schistosoma mansoni pyruvate kinase 0.0034 0.0458 0.054
Echinococcus multilocularis lamin dm0 0.0083 0.1546 0.1821
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0595 0.0701
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.1318 0.2199
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Brugia malayi beta-lactamase 0.0073 0.1318 0.1697
Echinococcus granulosus pyruvate kinase 0.0017 0.0093 0.0109
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.2779 0.2744
Schistosoma mansoni hypothetical protein 0.0351 0.7494 0.8831
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.0252 0.1238
Echinococcus granulosus pyruvate kinase 0.0034 0.0458 0.054
Loa Loa (eye worm) type III restriction enzyme 0.0016 0.0063 0.0075
Echinococcus multilocularis pyruvate kinase 0.0017 0.0093 0.0109
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.1318 0.1277
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.1318 0.2199
Onchocerca volvulus 0.0015 0.0048 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0458 0.0764
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0122 0.0144
Schistosoma mansoni glucose transport protein 0.0109 0.2128 0.2508
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0048 0.0073
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0248 0.0729
Echinococcus granulosus SPRY domain containing protein 0.0016 0.0063 0.0074
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0048 0.0061
Trypanosoma brucei glucose transporter, putative 0.0034 0.0458 0.225
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0021 0.0166 0.0119
Leishmania major pyruvate kinase 0.0034 0.0458 0.225
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0692 0.0816
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0794 0.39
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0056
Brugia malayi Cam kinase protein 1 0.0033 0.0449 0.0578
Echinococcus multilocularis calcium activated potassium channel 0.0015 0.0046 0.0055
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0122 0.0601
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0048 0.0234
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Schistosoma mansoni transient receptor potential channel 0.0262 0.5514 0.6497
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.0752 0.0886
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0122 0.0144
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.1318 0.1277
Echinococcus multilocularis transient receptor potential gamma protein 0.0395 0.8487 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0048 0.0056
Trypanosoma brucei glucose transporter, putative 0.0034 0.0458 0.225
Plasmodium falciparum DNA repair and recombination protein RAD54, putative 0.0016 0.0063 0.0016
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0449 0.0404
Entamoeba histolytica hypothetical protein 0.0037 0.0529 0.0654
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.1318 0.6475
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0056
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0063 0.0074
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0122 0.0601
Toxoplasma gondii sugar transporter ST2 0.0015 0.0048 0.0073
Loa Loa (eye worm) hypothetical protein 0.0083 0.1546 0.1821
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0056
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Plasmodium vivax ataxin-2 like protein, putative 0.0105 0.2036 0.2001
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0248 0.028
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.1546 0.1821
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0337 0.7186 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0033 0.0434 0.0558
Onchocerca volvulus 0.0051 0.0841 0.2641
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0139 0.2791 0.2756
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.5995 0.8328
Entamoeba histolytica hypothetical protein 0.0037 0.0529 0.0654
Brugia malayi intermediate filament protein 0.0083 0.1546 0.199
Trypanosoma brucei glucose transporter, putative 0.0034 0.0458 0.225
Echinococcus multilocularis SPRY domain containing protein 0.0016 0.0063 0.0074
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.5995 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.1318 0.1277
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0449 0.0529
Entamoeba histolytica hypothetical protein 0.0096 0.1835 0.2488
Schistosoma mansoni pyruvate kinase 0.0034 0.0458 0.054
Echinococcus multilocularis pyruvate kinase 0.0017 0.0093 0.0109
Brugia malayi follicle stimulating hormone receptor 0.0265 0.5585 0.7191
Onchocerca volvulus 0.0015 0.0048 0.015
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0458 0.0764
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.1724 0.222
Loa Loa (eye worm) RNA binding protein 0.0073 0.1323 0.1559
Onchocerca volvulus 0.0015 0.0048 0.015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0115 0.2257 0.266
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0048 0.0234
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0252 0.0297
Onchocerca volvulus 0.0015 0.0048 0.015
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0458 0.0412
Brugia malayi Sugar transporter family protein 0.0015 0.0048 0.0061
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0033 0.0434 0.0511
Echinococcus multilocularis short transient receptor potential channel 6 0.0262 0.5514 0.6497
Brugia malayi MH2 domain containing protein 0.0123 0.2434 0.3133
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0458 0.054
Echinococcus granulosus tumor protein p63 0.0349 0.7456 0.8785
Onchocerca volvulus 0.0083 0.1546 0.4851
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0033 0.0434 0.1019
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0841 0.0991
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Echinococcus granulosus pyruvate kinase 0.0017 0.0093 0.0109
Toxoplasma gondii sugar transporter ST1 0.0015 0.0048 0.0073
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0122 0.0601
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0048 0.0056
Loa Loa (eye worm) hypothetical protein 0.0081 0.1512 0.1782
Loa Loa (eye worm) hypothetical protein 0.0073 0.1318 0.1553
Trichomonas vaginalis chaperonin, putative 0.0025 0.0252 0.042
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0033 0.0434 0.0558
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0449 0.0686
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0601
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0449 0.0529
Echinococcus multilocularis solute carrier family 22 0.0015 0.0048 0.0056
Loa Loa (eye worm) hypothetical protein 0.0395 0.8487 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0049 0.0794 0.075
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0115 0.2257 0.266
Brugia malayi hypothetical protein 0.0015 0.0048 0.0061
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.2779 0.9955
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0449 0.0748
Echinococcus granulosus solute carrier family 22 0.0015 0.0048 0.0056
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0248 0.1217
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0773 0.0995
Echinococcus granulosus TRP transient receptor potential channel 0.0147 0.2972 0.3503
Schistosoma mansoni tar DNA-binding protein 0.0073 0.1323 0.1559
Leishmania major pyruvate kinase 0.0034 0.0458 0.225
Trypanosoma brucei THT1 - hexose transporter, putative 0.0034 0.0458 0.225
Onchocerca volvulus 0.0015 0.0048 0.015
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0458 0.225
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.1323 0.1559
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.5995 0.8328
Brugia malayi hypothetical protein 0.0068 0.1211 0.1559
Echinococcus multilocularis dna repair and recombination protein rad54 0.0016 0.0063 0.0074
Brugia malayi isocitrate dehydrogenase 0.0049 0.0794 0.1023
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.0252 0.0297
Loa Loa (eye worm) hypothetical protein 0.0157 0.3186 0.3754
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0118 0.0578
Entamoeba histolytica hypothetical protein 0.0037 0.0529 0.0654
Mycobacterium leprae Probable lipase LipE 0.0073 0.1318 0.4389
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0449 0.0404
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0363 0.7766 0.9151
Schistosoma mansoni glucose transport protein 0.0109 0.2128 0.2508
Giardia lamblia Pyruvate kinase 0.0017 0.0093 0.0063
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0048 0.008
Echinococcus granulosus solute carrier family 22 0.0015 0.0048 0.0056
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.0252 0.1238
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0601
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0147 0.2972 0.3503
Echinococcus multilocularis pyruvate kinase 0.0034 0.0458 0.054
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0048 0.0056
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0458 0.054
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.4932 0.5811
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0056
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0122 0.0158
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0449 0.0529
Giardia lamblia Prolyl-tRNA synthetase 0.0033 0.0434 0.0541
Loa Loa (eye worm) TAR-binding protein 0.0073 0.1323 0.1559
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0109 0.2128 0.2508
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0449 0.0404
Schistosoma mansoni hypothetical protein 0.0115 0.2257 0.266
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0109 0.2128 0.2508
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.0252 0.0297
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0458 0.1438
Loa Loa (eye worm) hypothetical protein 0.0024 0.0231 0.0272
Onchocerca volvulus 0.0015 0.0048 0.015
Toxoplasma gondii ABC1 family protein 0.0073 0.1318 0.2013
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0021 0.0166 0.0119
Toxoplasma gondii LsmAD domain-containing protein 0.0105 0.2036 0.311
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0122 0.0601
Onchocerca volvulus 0.0015 0.0048 0.015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0056
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.0016 0.0063 0.0075
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Loa Loa (eye worm) hypothetical protein 0.0024 0.0248 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.2128 0.3551
Loa Loa (eye worm) hypothetical protein 0.0115 0.2257 0.266
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.5995 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0048 0.008
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0458 0.1112
Loa Loa (eye worm) hypothetical protein 0.0073 0.1318 0.1553
Schistosoma mansoni hypothetical protein 0.0115 0.2257 0.266
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0122 0.0158
Loa Loa (eye worm) hypothetical protein 0.0134 0.268 0.3158
Brugia malayi Isocitrate dehydrogenase 0.0049 0.0794 0.1023
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.5995 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.1724 0.2032

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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