Detailed information for compound 694251

Basic information

Technical information
  • TDR Targets ID: 694251
  • Name: 2-furan-2-yl-5-[(4-methylpiperazin-1-yl)-(4-n itrophenyl)methyl]-[1,3]thiazolo[2,3-e][1,2,4 ]triazol-6-ol
  • MW: 440.476 | Formula: C20H20N6O4S
  • H donors: 1 H acceptors: 5 LogP: 2.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(CC1)C(c1sc2n(c1O)nc(n2)c1ccco1)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C20H20N6O4S/c1-23-8-10-24(11-9-23)16(13-4-6-14(7-5-13)26(28)29)17-19(27)25-20(31-17)21-18(22-25)15-3-2-12-30-15/h2-7,12,16,27H,8-11H2,1H3
  • InChiKey: UNHKIQDXVIWFMP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-furyl)-5-[(4-methylpiperazin-1-yl)-(4-nitrophenyl)methyl]thiazolo[2,3-e][1,2,4]triazol-6-ol
  • 2-(2-furyl)-5-[(4-methyl-1-piperazinyl)-(4-nitrophenyl)methyl]-6-thiazolo[2,3-e][1,2,4]triazolol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.015 0.042 0.0524
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0045 0.0045
Echinococcus granulosus thioredoxin glutathione reductase 0.0087 0.019 0.019
Echinococcus granulosus lysine specific demethylase 5A 0.0289 0.0932 0.0932
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.0154 0.0192
Trichomonas vaginalis chromobox protein, putative 0.0037 0.0008 0.0003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0008 0.001
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0818 0.2871 0.2871
Entamoeba histolytica hypothetical protein 0.0037 0.0008 0.0005
Mycobacterium tuberculosis Probable oxidoreductase 0.0219 0.0675 0.1724
Brugia malayi Bromodomain containing protein 0.0189 0.0563 0.0702
Schistosoma mansoni hypothetical protein 0.0083 0.0176 0.0176
Trichomonas vaginalis Heterochromatin protein, putative 0.0037 0.0008 0.0003
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0065 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.003
Echinococcus granulosus jumonji domain containing protein 0.0262 0.0834 0.0834
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0108 0.0108
Echinococcus multilocularis geminin 0.0175 0.0512 0.0512
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0071 0.0133 0.0149
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0065 0.0081
Brugia malayi hypothetical protein 0.0037 0.0008 0.001
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0128 0.034 0.0372
Loa Loa (eye worm) PHD-finger family protein 0.0189 0.0563 0.0702
Leishmania major trypanothione reductase 0.0086 0.0188 0.0519
Loa Loa (eye worm) hypothetical protein 0.015 0.042 0.0524
Giardia lamblia DINP protein human, muc B family 0.0057 0.0082 0.004
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0065 0.0168
Onchocerca volvulus 0.2527 0.9137 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0263 0.0836 0.1044
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.0082 0.0082
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0996 0.3522 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0956 0.3378 0.9581
Schistosoma mansoni hypothetical protein 0.0289 0.0929 0.0929
Loa Loa (eye worm) hypothetical protein 0.0083 0.0176 0.022
Brugia malayi Inositol-1 0.008 0.0164 0.0204
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1222 0.4353 0.4761
Echinococcus multilocularis Chromo domain 0.0037 0.0008 0.0008
Brugia malayi beta-lactamase 0.015 0.042 0.0524
Trichomonas vaginalis esterase, putative 0.015 0.042 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0008 0.0003
Brugia malayi latrophilin 2 splice variant baaae 0.018 0.0531 0.0663
Loa Loa (eye worm) hypothetical protein 0.0037 0.0008 0.001
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0045 0.0045
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0077 0.0154 0.0154
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.0229 0.0229
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0037 0.0008 0.001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.015 0.042 0.0524
Entamoeba histolytica hypothetical protein 0.011 0.0274 0.0616
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0008 0.0003
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0045 0.0049
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0108 0.0108
Schistosoma mansoni inositol monophosphatase 0.008 0.0164 0.0164
Brugia malayi F/Y-rich N-terminus family protein 0.0073 0.014 0.0175
Plasmodium vivax thioredoxin reductase, putative 0.0086 0.0188 0.0513
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0057 0.0082 0.0216
Brugia malayi jmjC domain containing protein 0.0077 0.0154 0.0192
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0271 0.029
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0037 0.0008 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.028 0.0899 0.0899
Schistosoma mansoni transient receptor potential channel 0.0064 0.0108 0.0108
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0065 0.0065
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0077 0.0154 0.0422
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0008 0.0003
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0045 0.0045
Loa Loa (eye worm) MBCTL1 0.0054 0.0069 0.0086
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0065 0.0168
Echinococcus multilocularis inositol monophosphatase 1 0.008 0.0164 0.0164
Brugia malayi M-phase phosphoprotein, mpp8 0.0037 0.0008 0.001
Loa Loa (eye worm) heterochromatin protein 1 0.0228 0.0708 0.0883
Brugia malayi mbt repeat family protein 0.0047 0.0045 0.0056
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0109 0.0271 0.0271
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0679 0.236 0.236
Plasmodium falciparum glutathione reductase 0.0086 0.0188 0.0513
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0083 0.0176 0.0176
Echinococcus multilocularis dna polymerase kappa 0.0057 0.0082 0.0082
Onchocerca volvulus 0.0096 0.0222 0.0243
Schistosoma mansoni inositol monophosphatase 0.008 0.0164 0.0164
Onchocerca volvulus 0.01 0.0239 0.0261
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0107 0.0107
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0065 0.0065
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0271 0.0271
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0082 0.0216
Mycobacterium ulcerans hypothetical protein 0.015 0.042 0.0983
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0996 0.3522 0.3522
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0065 0.0065
Entamoeba histolytica hypothetical protein 0.0037 0.0008 0.0005
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0037 0.0008 0.0008
Trichomonas vaginalis DNA polymerase eta, putative 0.0057 0.0082 0.0083
Schistosoma mansoni protein phosphatase 2C 0.0077 0.0154 0.0154
Echinococcus granulosus Chromo domain 0.0037 0.0008 0.0008
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0077 0.0154 0.0422
Echinococcus granulosus chromobox protein 2 0.0037 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0054 0.0069 0.0086
Echinococcus granulosus PHD finger protein rhinoceros 0.0189 0.0563 0.0563
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0077 0.0154 0.0422
Loa Loa (eye worm) IMP dehydrogenase 1 0.0996 0.3522 0.4396
Trichomonas vaginalis chromobox protein, putative 0.0228 0.0708 0.0769
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0065 0.0168
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0307 0.0996 0.0996
Giardia lamblia Fructose-bisphosphate aldolase 0.1222 0.4353 1
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0271 0.029
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0197 0.0594 0.1489
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0203 0.0216
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.042 0.0454
Echinococcus granulosus jumonji domain containing 1A 0.0077 0.0154 0.0154
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.0154 0.0192
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0996 0.3522 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0194 0.0581 0.1451
Schistosoma mansoni chromobox protein 0.0037 0.0008 0.0008
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0062 0.0097 0.026
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0082 0.0216
Brugia malayi MH2 domain containing protein 0.0379 0.126 0.1572
Leishmania major DNA polymerase eta, putative 0.0057 0.0082 0.0216
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0107 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0008 0.0003
Loa Loa (eye worm) RNA binding protein 0.0064 0.0107 0.0134
Plasmodium falciparum JmjC domain-containing protein, putative 0.0077 0.0154 0.0415
Loa Loa (eye worm) hypothetical protein 0.018 0.0531 0.0663
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0037 0.0008 0.0008
Onchocerca volvulus Alhambra homolog 0.0189 0.0563 0.0616
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.0077 0.0154 0.0192
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0069 0.0069
Mycobacterium tuberculosis Conserved protein 0.015 0.042 0.0983
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.0229 0.0229
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0082 0.0216
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0062 0.0097 0.026
Schistosoma mansoni hypothetical protein 0.0037 0.0008 0.0008
Mycobacterium tuberculosis Probable lipase LipD 0.015 0.042 0.0983
Brugia malayi SET domain containing protein 0.0049 0.0051 0.0064
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.008 0.0164 0.0238
Leishmania major hypothetical protein, conserved 0.0051 0.0058 0.0148
Loa Loa (eye worm) hypothetical protein 0.0128 0.034 0.0424
Mycobacterium tuberculosis Probable reductase 0.0197 0.0594 0.1489
Brugia malayi hypothetical protein 0.0051 0.0058 0.0072
Schistosoma mansoni aldehyde dehydrogenase 0.0194 0.0581 0.0581
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0197 0.0594 0.1361
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0008 0.0003
Echinococcus granulosus neuropeptide receptor A26 0.1028 0.3642 0.3642
Toxoplasma gondii PHD-finger domain-containing protein 0.0189 0.0563 0.1584
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0138 0.0376 0.0411
Trypanosoma brucei unspecified product 0.004 0.0016 0.003
Echinococcus granulosus phd:f box containing protein 0.0077 0.0154 0.0154
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0996 0.3522 1
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.042 0.1178
Schistosoma mansoni kinase 0.0056 0.0075 0.0075
Entamoeba histolytica serine/threonine protein kinase, putative 0.0109 0.0271 0.0609
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0037 0.0008 0.0008
Echinococcus multilocularis Chromobox protein 3 0.0037 0.0008 0.0008
Brugia malayi jmjC domain containing protein 0.0077 0.0154 0.0192
Echinococcus multilocularis microtubule associated protein 2 0.2762 1 1
Schistosoma mansoni hypothetical protein 0.0083 0.0176 0.0176
Schistosoma mansoni alpha-glucosidase 0.0142 0.0393 0.0393
Schistosoma mansoni microtubule-associated protein tau 0.2762 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0194 0.0581 0.1451
Onchocerca volvulus Serine\/threonine kinase homolog 0.0109 0.0271 0.0296
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0077 0.0154 0.0154
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0271 0.029
Schistosoma mansoni hypothetical protein 0.0189 0.0563 0.0563
Trypanosoma brucei unspecified product 0.004 0.0016 0.003
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0082 0.0216
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.0217 0.0217
Trichomonas vaginalis chromobox protein, putative 0.0138 0.0376 0.0405
Schistosoma mansoni alpha-glucosidase 0.0142 0.0393 0.0393
Loa Loa (eye worm) jmjC domain-containing protein 0.0289 0.0932 0.1163
Schistosoma mansoni hypothetical protein 0.018 0.0531 0.0531
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0065 0.0065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0263 0.0836 0.1044
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0037 0.0008 0.0008
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0045 0.0056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1222 0.4353 0.4761
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0996 0.3522 1
Onchocerca volvulus 0.015 0.042 0.046
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0082 0.0216
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0197 0.0594 0.1489
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0194 0.0581 0.1636
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.0229 0.0229
Schistosoma mansoni transient receptor potential channel 0.0064 0.0108 0.0108
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0154 0.0154
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0083 0.0176 0.0176
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0008 0.0003
Loa Loa (eye worm) transcription factor SMAD2 0.0379 0.126 0.1572
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0037 0.0008 0.0007
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0107 0.0134
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.0217 0.0217
Mycobacterium tuberculosis Probable esterase LipL 0.015 0.042 0.0983
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0006 0.0006
Brugia malayi glutathione reductase 0.0086 0.0188 0.0235
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0082 0.0216
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0219 0.0675 0.1724
Trichomonas vaginalis chromobox protein, putative 0.0037 0.0008 0.0003
Brugia malayi mbt repeat family protein 0.0047 0.0045 0.0056
Schistosoma mansoni hypothetical protein 0.0347 0.1143 0.1143
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.028 0.0899 0.1122
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0996 0.3522 1
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.044 0.1484 0.4076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.0899 0.0899
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0996 0.3522 1
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.042 0.0454
Schistosoma mansoni transient receptor potential channel 0.0097 0.0229 0.0229
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0274 0.0274
Brugia malayi RNA binding protein 0.0064 0.0107 0.0134
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0271 0.0753
Trichomonas vaginalis hypothetical protein 0.0037 0.0008 0.0003
Loa Loa (eye worm) jmjC domain-containing protein 0.0389 0.1299 0.1621
Loa Loa (eye worm) hypothetical protein 0.0062 0.0097 0.0121
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0065 0.0065
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0597 0.206 0.5751
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0082 0.0216
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0109 0.0271 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0008 0.0003
Echinococcus granulosus JmjC domain containing protein 4 0.0077 0.0154 0.0154
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0065 0.0065
Plasmodium falciparum phd finger protein, putative 0.0189 0.0563 0.1578
Leishmania major inosine-5-monophosphate dehydrogenase 0.0996 0.3522 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0037 0.0008 0.0008
Trypanosoma cruzi DNA polymerase eta, putative 0.0057 0.0082 0.0216
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.222 0.8012 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0083 0.0176 0.022
Echinococcus granulosus tar DNA binding protein 0.0064 0.0107 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0082 0.0216
Echinococcus granulosus tumor protein p63 0.0326 0.1068 0.1068
Echinococcus multilocularis lysine specific demethylase 6a 0.0077 0.0154 0.0154
Giardia lamblia PHD finger protein 15 0.0189 0.0563 0.1162
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0097 0.0254
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.044 0.1484 0.1853
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0083 0.0176 0.0176
Brugia malayi Heterochromatin protein 1 0.0228 0.0708 0.0883
Echinococcus granulosus lysine specific demethylase 6a 0.0077 0.0154 0.0154
Treponema pallidum fructose-bisphosphate aldolase 0.1222 0.4353 0.5
Brugia malayi chromobox protein homolog 3 0.0128 0.034 0.0424
Toxoplasma gondii aldehyde dehydrogenase 0.0194 0.0581 0.1636
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.0557 0.0557
Echinococcus granulosus inositol monophosphatase 1 0.008 0.0164 0.0164
Schistosoma mansoni phosphatidylserine receptor 0.0077 0.0154 0.0154
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1222 0.4353 0.4761
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0057 0.0082 0.0083
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.015 0.042 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.034 0.0366
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.0478 0.0596
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.015 0.042 0.0524
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0077 0.0154 0.0422
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0077 0.0154 0.0422
Entamoeba histolytica hypothetical protein 0.011 0.0274 0.0616
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0083 0.0176 0.022
Trypanosoma brucei polo-like protein kinase 0.0109 0.0271 0.0753
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0045 0.0045
Schistosoma mansoni chromobox protein 0.0228 0.0708 0.0708
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0006 0.0007
Echinococcus multilocularis chromobox protein 2 0.0037 0.0008 0.0008
Brugia malayi PHD-finger family protein 0.0189 0.0563 0.0702
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0008 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0203 0.0216
Toxoplasma gondii IMP dehydrogenas 0.0996 0.3522 1
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0045 0.0045
Brugia malayi hypothetical protein 0.011 0.0274 0.0342
Leishmania major hypothetical protein, conserved 0.0077 0.0154 0.0422
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0004 0.0004
Mycobacterium tuberculosis Conserved protein 0.015 0.042 0.0983
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0109 0.0271 0.0753
Echinococcus granulosus Chromobox protein 3 0.0037 0.0008 0.0008
Echinococcus multilocularis neuropeptide receptor A26 0.1028 0.3642 0.3642
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0058 0.0142
Toxoplasma gondii thioredoxin reductase 0.0086 0.0188 0.0519
Schistosoma mansoni hypothetical protein 0.0175 0.0512 0.0512
Entamoeba histolytica hypothetical protein 0.011 0.0274 0.0616
Loa Loa (eye worm) hypothetical protein 0.015 0.042 0.0524
Schistosoma mansoni hypothetical protein 0.0062 0.0097 0.0097
Echinococcus multilocularis jumonji domain containing protein 0.0262 0.0834 0.0834
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0107 0.0134
Mycobacterium tuberculosis Probable conserved lipoprotein 0.015 0.042 0.0983
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0069 0.0069
Echinococcus multilocularis GPCR, family 2 0.0083 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0037 0.0008 0.001
Brugia malayi Calcitonin receptor-like protein seb-1 0.0263 0.0836 0.1044
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0086 0.0188 0.0309
Loa Loa (eye worm) hypothetical protein 0.015 0.042 0.0524
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0058 0.0148
Onchocerca volvulus Putative GMP reductase 0.044 0.1484 0.1625
Echinococcus multilocularis phd:f box containing protein 0.0077 0.0154 0.0154
Trichomonas vaginalis chromobox protein, putative 0.0037 0.0008 0.0003
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0164 0.0449
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0318 0.1039 0.1039
Trypanosoma brucei protein kinase, putative 0.0053 0.0065 0.0168
Loa Loa (eye worm) hypothetical protein 0.0318 0.1039 0.1297
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0109 0.0271 0.0338
Brugia malayi RNA, U transporter 1 0.0092 0.021 0.0262
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0996 0.3522 1
Brugia malayi Protein cec-1. 0.0037 0.0008 0.001
Trichomonas vaginalis myo inositol monophosphatase, putative 0.008 0.0164 0.0173
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0045 0.0045
Echinococcus multilocularis peregrin 0.0189 0.0563 0.0563
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0069 0.0069
Loa Loa (eye worm) CHromoDomain protein family member 0.0037 0.0008 0.001
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0478 0.0478
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0219 0.0675 0.1599
Trichomonas vaginalis penicillin-binding protein, putative 0.015 0.042 0.0454
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1222 0.4353 1
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0996 0.3522 0.4396
Mycobacterium ulcerans lipase LipD 0.015 0.042 0.0983
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0065 0.0168
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.008 0.0164 0.0449
Loa Loa (eye worm) hypothetical protein 0.0036 0.0004 0.0005
Brugia malayi Pre-SET motif family protein 0.222 0.8012 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0008 0.0003
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.0082 0.0082
Schistosoma mansoni aldehyde dehydrogenase 0.0194 0.0581 0.0581
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0271 0.0753
Echinococcus multilocularis neuropeptide s receptor 0.1028 0.3642 0.3642
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0164 0.0449
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0065 0.0065
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0996 0.3522 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0087 0.019 0.019
Echinococcus multilocularis beta LACTamase domain containing family member 0.015 0.042 0.042
Schistosoma mansoni chromobox protein 0.0228 0.0708 0.0708
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.015 0.042 0.0983
Echinococcus granulosus chromobox protein 1 0.0228 0.0708 0.0708
Leishmania major hypothetical protein, conserved 0.015 0.042 0.1178
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0597 0.206 0.5751
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0047 0.0045 0.0056
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0058 0.0142
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0271 0.029
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0097 0.026
Plasmodium vivax JmjC domain containing protein 0.0077 0.0154 0.0415
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0008 0.0003
Trypanosoma cruzi GMP reductase 0.0996 0.3522 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0356 0.1176 0.1176
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0069 0.0086
Schistosoma mansoni jumonji/arid domain-containing protein 0.0289 0.0932 0.0932
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0065 0.0168
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.0082 0.0102
Echinococcus granulosus GPCR family 2 0.0083 0.0176 0.0176
Brugia malayi follicle stimulating hormone receptor 0.0488 0.1662 0.2074
Trypanosoma cruzi GMP reductase 0.0996 0.3522 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0219 0.0675 0.1724
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0058 0.0142
Mycobacterium ulcerans esterase/lipase LipP 0.015 0.042 0.0983
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.0082 0.0082
Entamoeba histolytica hypothetical protein 0.011 0.0274 0.0616
Leishmania major guanosine monophosphate reductase 0.0996 0.3522 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0082 0.0216
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.0557 0.0557
Brugia malayi beta-lactamase family protein 0.015 0.042 0.0524
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0197 0.0594 0.1489
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0082 0.0216
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.0154 0.0192
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0996 0.3522 0.3522
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0194 0.0581 0.0581
Echinococcus multilocularis snurportin 1 0.0347 0.1143 0.1143
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0082 0.0216
Schistosoma mansoni DNA polymerase eta 0.0057 0.0082 0.0082
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.015 0.042 0.0524
Trichomonas vaginalis inositol monophosphatase, putative 0.008 0.0164 0.0173
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0062 0.0097 0.0254
Loa Loa (eye worm) hypothetical protein 0.0263 0.0836 0.1044
Plasmodium falciparum thioredoxin reductase 0.0086 0.0188 0.0513
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0046 0.0046
Plasmodium vivax hypothetical protein, conserved 0.015 0.042 0.1172
Trichomonas vaginalis myo inositol monophosphatase, putative 0.008 0.0164 0.0173
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0008 0.0003
Schistosoma mansoni alpha glucosidase 0.0037 0.0006 0.0006
Mycobacterium tuberculosis Probable hydrolase 0.015 0.042 0.0983
Onchocerca volvulus 0.0037 0.0008 0.0009
Brugia malayi serine/threonine-protein kinase plk-2 0.0109 0.0271 0.0338
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0008 0.0003
Echinococcus multilocularis JmjC domain containing protein 4 0.0077 0.0154 0.0154
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0008 0.0003
Loa Loa (eye worm) hypothetical protein 0.0061 0.0096 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0008 0.0003
Brugia malayi jmjC domain containing protein 0.0077 0.0154 0.0192
Trichomonas vaginalis set domain proteins, putative 0.2527 0.9137 1
Brugia malayi TAR-binding protein 0.0064 0.0107 0.0134
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.028 0.0899 0.0899
Loa Loa (eye worm) hypothetical protein 0.0057 0.0082 0.0102
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0597 0.206 0.5686
Echinococcus multilocularis dna polymerase eta 0.0057 0.0082 0.0082
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0108 0.0108
Trypanosoma brucei GMP reductase 0.0996 0.3522 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0189 0.0563 0.1584
Loa Loa (eye worm) hypothetical protein 0.01 0.0239 0.0298
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0107 0.0134
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0065 0.0168
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0107 0.0107
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.0082 0.0102
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0083 0.0176 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0082 0.0216
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0062 0.0097 0.026
Plasmodium vivax hypothetical protein, conserved 0.0189 0.0563 0.1578
Brugia malayi Valyl-tRNA synthetase 0.0037 0.0008 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0082 0.0216
Mycobacterium leprae conserved hypothetical protein 0.015 0.042 0.0847
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0318 0.1039 0.1039
Echinococcus multilocularis chromobox protein 1 0.0228 0.0708 0.0708
Plasmodium vivax glutathione reductase, putative 0.0086 0.0188 0.0513
Onchocerca volvulus 0.0047 0.0045 0.0049
Trichomonas vaginalis penicillin-binding protein, putative 0.015 0.042 0.0454
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.015 0.042 0.042
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.0082 0.0175
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0008 0.0005
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.007 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0082 0.0216
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0008 0.0003
Brugia malayi Pre-SET motif family protein 0.0318 0.1039 0.1297
Trichomonas vaginalis chromobox protein, putative 0.0228 0.0708 0.0769
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1222 0.4353 0.4761
Schistosoma mansoni phd/f-box containing protein 0.0077 0.0154 0.0154
Leishmania major DNA polymerase kappa, putative 0.0057 0.0082 0.0216
Loa Loa (eye worm) hypothetical protein 0.0048 0.0046 0.0058
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0189 0.0563 0.0563
Echinococcus granulosus beta LACTamase domain containing family member 0.015 0.042 0.042
Trypanosoma brucei DNA polymerase eta, putative 0.0057 0.0082 0.0216
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0318 0.1039 0.1039
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0069 0.0069
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0488 0.1662 0.2074
Loa Loa (eye worm) hypothetical protein 0.0037 0.0008 0.001
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0037 0.0008 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.015 0.042 0.1178
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0164 0.0449
Onchocerca volvulus 0.0048 0.0046 0.0051
Onchocerca volvulus 0.015 0.042 0.046
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0082 0.0216
Plasmodium vivax SET domain protein, putative 0.0318 0.1039 0.2933
Echinococcus multilocularis tumor protein p63 0.0326 0.1068 0.1068
Brugia malayi MAP kinase sur-1 0.0053 0.0065 0.0081
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0008 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0086 0.0188 0.0519
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.0082 0.0082
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.0175 0.0512 0.0512
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0197 0.0594 0.1489
Loa Loa (eye worm) hypothetical protein 0.0189 0.0563 0.0702
Trypanosoma brucei trypanothione reductase 0.0086 0.0188 0.0519
Trypanosoma brucei unspecified product 0.0057 0.0082 0.0216
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0004 0.0004
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0058 0.0148
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0077 0.0154 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0016 0.003
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0478 0.0478
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0107 0.0107
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0058 0.0148
Loa Loa (eye worm) MH2 domain-containing protein 0.0379 0.126 0.1572
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0008 0.0005
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0556 0.1909 0.5311
Entamoeba histolytica hypothetical protein 0.0037 0.0008 0.0005
Loa Loa (eye worm) beta-lactamase 0.015 0.042 0.0524
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0037 0.0008 0.0007
Loa Loa (eye worm) thioredoxin reductase 0.0086 0.0188 0.0235
Onchocerca volvulus 0.015 0.042 0.046
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.0082 0.0102
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0996 0.3522 1
Echinococcus multilocularis chromobox protein 1 0.0228 0.0708 0.0708
Schistosoma mansoni chromobox protein 0.0037 0.0008 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0271 0.029
Loa Loa (eye worm) hypothetical protein 0.0051 0.0058 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.042 0.1178
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0996 0.3522 0.3522
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0164 0.0449
Echinococcus granulosus dna polymerase kappa 0.0057 0.0082 0.0082
Echinococcus granulosus chromobox protein 1 0.0228 0.0708 0.0708
Schistosoma mansoni hypothetical protein 0.0083 0.0176 0.0176
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0107 0.0107
Mycobacterium tuberculosis Probable lipase LipE 0.015 0.042 0.0983
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0271 0.029
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0107 0.0107
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.028 0.0899 0.0899
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0274 0.0274
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0318 0.1039 0.1039
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.015 0.042 0.0983
Brugia malayi Thioredoxin reductase 0.0086 0.0188 0.0235
Loa Loa (eye worm) hypothetical protein 0.034 0.1116 0.1393
Toxoplasma gondii ABC1 family protein 0.015 0.042 0.1178
Schistosoma mansoni jumonji/arid domain-containing protein 0.0289 0.0932 0.0932
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0996 0.3522 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0008 0.0003
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0556 0.1909 0.5241
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1222 0.4353 0.4761
Mycobacterium tuberculosis Conserved protein 0.015 0.042 0.0983
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.034 0.0366
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.015 0.042 0.042
Echinococcus granulosus dna polymerase eta 0.0057 0.0082 0.0082
Mycobacterium ulcerans aldehyde dehydrogenase 0.0194 0.0581 0.1451
Entamoeba histolytica myo-inositol monophosphatase, putative 0.008 0.0164 0.0363
Echinococcus granulosus geminin 0.0175 0.0512 0.0512
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0008 0.0003
Brugia malayi Associated with TFs and helicases family protein 0.0037 0.0008 0.001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0318 0.1039 0.1039
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0347 0.1143 0.1426
Brugia malayi CHD4 protein 0.0037 0.0008 0.001
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0004 0.0005
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.015 0.042 0.0983
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.0899 0.0899
Brugia malayi jmjC domain containing protein 0.0077 0.0154 0.0192
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0058 0.0148
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.028 0.0899 0.0899
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0065 0.0168
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0077 0.0154 0.0192
Schistosoma mansoni jumonji domain containing protein 0.0552 0.1894 0.1894
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0271 0.029
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0008 0.0003
Echinococcus granulosus neuropeptide s receptor 0.1028 0.3642 0.3642
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0274 0.0274
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0008 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.042 0.0454
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0006 0.0006
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.044 0.1484 0.3987
Echinococcus granulosus peregrin 0.0189 0.0563 0.0563
Loa Loa (eye worm) glutathione reductase 0.0086 0.0188 0.0235
Loa Loa (eye worm) inositol-1 0.008 0.0164 0.0204
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0194 0.0581 0.0581
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.0899 0.0899
Loa Loa (eye worm) hypothetical protein 0.0037 0.0008 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1222 0.4353 0.4761
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0008 0.0003
Brugia malayi PHD-finger family protein 0.0062 0.0097 0.0121
Loa Loa (eye worm) hypothetical protein 0.0037 0.0008 0.001
Giardia lamblia Kinase, PLK 0.0109 0.0271 0.048
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0008 0.0003
Loa Loa (eye worm) GMP reductase 0.044 0.1484 0.1853
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0037 0.0008 0.0008
Echinococcus multilocularis PHD finger protein rhinoceros 0.0189 0.0563 0.0563
Mycobacterium ulcerans beta-lactamase 0.015 0.042 0.0983
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0008 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1222 0.4353 0.4761
Brugia malayi AF-10 protein 0.0062 0.0097 0.0121
Mycobacterium tuberculosis Probable dehydrogenase 0.0197 0.0594 0.1489
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.044 0.1484 0.1853
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1222 0.4353 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0069 0.0069
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0037 0.0008 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0082 0.0216
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0996 0.3522 1
Schistosoma mansoni hypothetical protein 0.0083 0.0176 0.0176
Mycobacterium leprae Probable lipase LipE 0.015 0.042 0.0847
Onchocerca volvulus 0.0037 0.0008 0.0009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.028 0.0899 0.1122
Echinococcus granulosus histone lysine methyltransferase setb 0.0318 0.1039 0.1039
Brugia malayi jmjC domain containing protein 0.0289 0.0932 0.1163
Loa Loa (eye worm) hypothetical protein 0.0097 0.0229 0.0285
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.0478 0.0596
Brugia malayi GMP reductase 0.044 0.1484 0.1853
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.007 0.007
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0679 0.236 0.236
Loa Loa (eye worm) hypothetical protein 0.0037 0.0008 0.001
Brugia malayi jmjC domain containing protein 0.0679 0.236 0.2945
Brugia malayi beta-lactamase family protein 0.015 0.042 0.0524
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0318 0.1039 0.2938
Echinococcus multilocularis lysine specific demethylase 5A 0.0289 0.0932 0.0932
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1222 0.4353 0.4761
Brugia malayi Latrophilin receptor protein 2 0.0083 0.0176 0.022
Schistosoma mansoni hypothetical protein 0.011 0.0274 0.0274
Onchocerca volvulus 0.0356 0.1176 0.1287
Trichomonas vaginalis chromobox protein, putative 0.0138 0.0376 0.0405
Echinococcus multilocularis jumonji domain containing 1A 0.0077 0.0154 0.0154
Echinococcus granulosus snurportin 1 0.0347 0.1143 0.1143
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0065 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0082 0.0216
Mycobacterium ulcerans aldehyde dehydrogenase 0.0194 0.0581 0.1451
Loa Loa (eye worm) helicase 0.0037 0.0008 0.001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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