TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 392.863 | Formula: C16H17ClN6O2S
H donors: 2 H acceptors: 6 LogP: 3.15 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(cc1)Cl)CSc1nnc2n1nc(c(n2)O)C(C)(C)C
InChi: 1S/C16H17ClN6O2S/c1-16(2,3)12-13(25)19-14-20-21-15(23(14)22-12)26-8-11(24)18-10-6-4-9(17)5-7-10/h4-7H,8H2,1-3H3,(H,18,24)(H,19,20,25)
InChiKey: VHPFWGUFFRSLFI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0069	0.0113	0.0113
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0191	0.0459	0.0459
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0237	0.0591	0.1565
Echinococcus multilocularis	inosine 5' monophosphate dehydrogenase 2	0.1339	0.3736	0.3736
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.0747	0.2048	0.5473
Trichomonas vaginalis	inositol monophosphatase, putative	0.0038	0.0022	0.0113
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.004	0.0029	0.0077
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0055	0.0072	0.0072
Trypanosoma cruzi	PAB1-binding protein , putative	0.0053	0.0065	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0019	0.0051
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0029	0.0077
Schistosoma mansoni	hypothetical protein	0.0037	0.0019	0.0019
Onchocerca volvulus		0.05	0.1342	0.837
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0095	0.0253
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0021	0.0055
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0021	0.0055
Onchocerca volvulus		0.0037	0.0021	0.0128
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0093	0.018	0.0465
Loa Loa (eye worm)	hypothetical protein	0.004	0.0029	0.0077
Trypanosoma brucei	unspecified product	0.004	0.0029	0.0059
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0166	0.0389	0.0389
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0439	0.1169	0.3128
Leishmania major	trypanothione reductase	0.0093	0.018	0.0483
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0038	0.0022	0.0041
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0021	0.0055
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0212	0.052	0.1377
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0143	0.0323	0.0865
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.0113	0.0284
Schistosoma mansoni	DNA polymerase eta	0.004	0.0029	0.0029
Plasmodium falciparum	glutathione reductase	0.0093	0.018	0.0483
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.0592	0.1603	0.428
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0029	0.0059
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0592	0.1603	0.4291
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0021	0.0103
Brugia malayi	MH2 domain containing protein	0.0238	0.0593	0.1588
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0032	0.0007	0.0018
Echinococcus granulosus	lysosomal alpha glucosidase	0.0166	0.0389	0.0389
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0021	0.0037
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0022	0.0041
Schistosoma mansoni	alpha glucosidase	0.0037	0.002	0.002
Trypanosoma cruzi	DNA polymerase eta, putative	0.004	0.0029	0.0077
Echinococcus granulosus	neuropeptide receptor A26	0.0906	0.2499	0.2499
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0032	0.0007	0.0018
Brugia malayi	beta-lactamase family protein	0.0037	0.0021	0.0055
Echinococcus granulosus	histone acetyltransferase MYST2	0.0055	0.0072	0.0072
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0034	0.0011	0.001
Plasmodium vivax	SET domain protein, putative	0.0063	0.0095	0.0253
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0022	0.0113
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0021	0.0037
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0069	0.0113	0.0113
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0021	0.0037
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0143	0.0323	0.0323
Trypanosoma brucei	glucosidase, putative	0.0037	0.002	0.0036
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0143	0.0323	0.0323
Mycobacterium tuberculosis	Probable oxidoreductase	0.0236	0.0588	0.1559
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0022	0.0059
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0032	0.0007	0.0018
Echinococcus multilocularis	neuropeptide receptor A26	0.0906	0.2499	0.2499
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0055	0.0072	0.0193
Echinococcus granulosus	inosine 5' monophosphate dehydrogenase 2	0.1339	0.3736	0.3736
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0048	0.0053	0.033
Leishmania major	hypothetical protein, conserved	0.0053	0.0065	0.0174
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.004	0.0029	0.0059
Plasmodium vivax	ataxin-2 like protein, putative	0.0053	0.0065	0.0174
Trichomonas vaginalis	esterase, putative	0.0037	0.0021	0.0103
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0021	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0021	0.0055
Loa Loa (eye worm)	mbt repeat family protein	0.0048	0.0053	0.0141
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0029	0.0059
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0055	0.0072	0.0072
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0021	0.0055
Mycobacterium tuberculosis	Conserved hypothetical protein	0.004	0.0029	0.0059
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0029	0.0059
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0021	0.0037
Schistosoma mansoni	microtubule-associated protein tau	0.3534	1	1
Brugia malayi	hypothetical protein	0.0034	0.0012	0.0032
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0021	0.0037
Echinococcus multilocularis	microtubule associated protein 2	0.3534	1	1
Onchocerca volvulus		0.0096	0.0189	0.1181
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0143	0.0323	0.0323
Loa Loa (eye worm)	IMP dehydrogenase 1	0.1339	0.3736	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.002	0.01
Mycobacterium leprae	PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD)	0.0592	0.1603	0.4274
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0021	0.0055
Brugia malayi	GMP reductase	0.0592	0.1603	0.4291
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0038	0.0022	0.2122
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0069	0.0113	0.0284
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0143	0.0323	0.0323
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0029	0.0059
Brugia malayi	Thioredoxin reductase	0.0093	0.018	0.0483
Mycobacterium tuberculosis	Probable dehydrogenase	0.0212	0.052	0.1377
Echinococcus granulosus	neutral alpha glucosidase AB	0.0037	0.002	0.002
Leishmania major	hypothetical protein, conserved	0.0037	0.0021	0.0055
Onchocerca volvulus		0.0244	0.061	0.3808
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0037	0.002	0.0054
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0021	0.0103
Brugia malayi	mbt repeat family protein	0.0048	0.0053	0.0141
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0063	0.0095	0.0095
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0038	0.0022	0.0041
Trypanosoma cruzi	GMP reductase	0.1339	0.3736	1
Schistosoma mansoni	sex comb on midleg homolog	0.0048	0.0053	0.0053
Mycobacterium tuberculosis	Probable reductase	0.0212	0.052	0.1377
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0055	0.0072	0.0072
Treponema pallidum	NADH oxidase	0.0032	0.0007	0.5
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0037	0.002	0.002
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0166	0.0389	0.1042
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.002	0.0054
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0021	0.0037
Trypanosoma brucei	DNA polymerase eta, putative	0.004	0.0029	0.0059
Schistosoma mansoni	aldehyde dehydrogenase	0.0069	0.0113	0.0113
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0022	0.0113
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0143	0.0323	0.0323
Plasmodium falciparum	glutathione reductase	0.0032	0.0007	0.0018
Schistosoma mansoni	aldehyde dehydrogenase	0.0069	0.0113	0.0113
Plasmodium falciparum	ataxin-2 like protein, putative	0.0053	0.0065	0.0174
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0019	0.0051
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0029	0.0077
Brugia malayi	follicle stimulating hormone receptor	0.024	0.0598	0.1601
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.002	0.01
Mycobacterium ulcerans	inosine 5'-monophosphate dehydrogenase	0.1339	0.3736	1
Schistosoma mansoni	alpha-glucosidase	0.0143	0.0323	0.0323
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0038	0.0022	0.0059
Brugia malayi	beta-lactamase	0.0037	0.0021	0.0055
Trichomonas vaginalis	DNA polymerase eta, putative	0.004	0.0029	0.0165
Trypanosoma brucei	GMP reductase	0.1339	0.3736	1
Loa Loa (eye worm)	glutathione reductase	0.0093	0.018	0.0483
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0022	0.0022
Trypanosoma cruzi	trypanothione reductase, putative	0.0093	0.018	0.0483
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0048	0.0053	0.0053
Echinococcus granulosus	neuropeptide s receptor	0.0906	0.2499	0.2499
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0037	0.002	0.0054
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD)	0.1339	0.3736	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0143	0.0323	0.0865
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.0113	0.0284
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0236	0.0588	0.1559
Schistosoma mansoni	inosine-5-monophosphate dehydrogenase	0.1339	0.3736	0.3736
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0022	0.0059
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0021	0.0037
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0029	0.0059
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0021	0.0037
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.002	0.01
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0067	0.018
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0212	0.052	0.1368
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0032	0.0007	0.0018
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.004	0.0029	0.0029
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.024	0.0598	0.1601
Schistosoma mansoni	alpha-glucosidase	0.0143	0.0323	0.0323
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0021	0.0037
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0143	0.0323	0.0323
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0021	0.0055
Echinococcus multilocularis	dna polymerase eta	0.004	0.0029	0.0029
Plasmodium falciparum	thioredoxin reductase	0.0032	0.0007	0.0018
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0032	0.0007	0.5
Brugia malayi	inosine-5'-monophosphate dehydrogenase family protein	0.1339	0.3736	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0065	0.0174
Brugia malayi	glutathione reductase	0.0093	0.018	0.0483
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0029	0.0059
Wolbachia endosymbiont of Brugia malayi	IMP dehydrogenase	0.1339	0.3736	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0021	0.0037
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0029	0.0077
Entamoeba histolytica	deoxycytidyl transferase, putative	0.004	0.0029	1
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0021	0.0037
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0236	0.0588	0.1559
Leishmania major	alpha glucosidase II subunit, putative	0.0037	0.002	0.0054
Onchocerca volvulus		0.0037	0.0021	0.0128
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0067	0.018
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0212	0.052	0.1377
Mycobacterium tuberculosis	Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase	0.1339	0.3736	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.002	0.0054
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0063	0.0095	0.0095
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0032	0.0007	0.0018
Onchocerca volvulus		0.0037	0.0021	0.0128
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0029	0.0059
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.1339	0.3736	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0212	0.052	0.1377
Brugia malayi	hypothetical protein	0.0053	0.0065	0.0174
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0048	0.0053	0.0053
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.087	0.2397	0.2397
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0166	0.0389	0.1042
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.002	0.01
Toxoplasma gondii	thioredoxin reductase	0.0093	0.018	0.0483
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0032	0.0007	0.0007
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0029	0.0059
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0021	0.0055
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0236	0.0588	0.155
Brugia malayi	Pre-SET motif family protein	0.0063	0.0095	0.0253
Trypanosoma cruzi	trypanothione reductase, putative	0.0032	0.0007	0.0018
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0021	0.0021
Plasmodium falciparum	inosine-5'-monophosphate dehydrogenase	0.1339	0.3736	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0029	0.0059
Loa Loa (eye worm)	MH2 domain-containing protein	0.0238	0.0593	0.1588
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0029	0.0059
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0029	0.0059
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0021	0.0021
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.004	0.0029	0.0029
Echinococcus granulosus	dna polymerase eta	0.004	0.0029	0.0029
Plasmodium falciparum	thioredoxin reductase	0.0093	0.018	0.0483
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0022	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0072	0.0193
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0032	0.0007	0.0018
Echinococcus multilocularis	neuropeptide s receptor	0.0906	0.2499	0.2499
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0055	0.0072	0.0072
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0032	0.0007	0.0018
Echinococcus multilocularis	inositol monophosphatase 1	0.0038	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0021	0.0055
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0021	0.0037
Mycobacterium leprae	Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena	0.0747	0.2048	0.5468
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0021	0.0037
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0032	0.0007	0.0018
Echinococcus granulosus	thioredoxin glutathione reductase	0.0094	0.0182	0.0182
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.002	0.01
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0063	0.0095	0.0253
Toxoplasma gondii	ABC1 family protein	0.0037	0.0021	0.0055
Loa Loa (eye worm)	GMP reductase	0.0592	0.1603	0.4291
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0032	0.0007	0.0007
Giardia lamblia	DINP protein human, muc B family	0.004	0.0029	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0053	0.0141
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.004	0.0029	0.0165
Leishmania major	DNA polymerase eta, putative	0.004	0.0029	0.0077
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0212	0.052	0.1377
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0029	0.0059
Trypanosoma brucei	trypanothione reductase	0.0093	0.018	0.0465
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0037	0.002	0.01
Schistosoma mansoni	cellular tumor antigen P53	0.0244	0.061	0.061
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0063	0.0095	0.0095
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0032	0.0007	0.0018
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0032	0.0007	0.0018
Plasmodium vivax	thioredoxin reductase, putative	0.0093	0.018	0.0483
Echinococcus granulosus	SAM and MBT domain containing protein	0.0048	0.0053	0.0053
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0032	0.0007	0.0018
Leishmania major	inosine-5-monophosphate dehydrogenase	0.1339	0.3736	1
Echinococcus granulosus	tumor protein p63	0.1666	0.4668	0.4668
Trypanosoma brucei	PAB1-binding protein , putative	0.0053	0.0065	0.0156
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0037	0.002	0.0054
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0069	0.0113	0.0302
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.1339	0.3736	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0032	0.0007	0.0018
Onchocerca volvulus	Putative GMP reductase	0.0592	0.1603	1
Schistosoma mansoni	hypothetical protein	0.0294	0.0754	0.0754
Plasmodium vivax	inosine-5'-monophosphate dehydrogenase, putative	0.1339	0.3736	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.002	0.01
Plasmodium vivax	glutathione reductase, putative	0.0093	0.018	0.0483
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0032	0.0007	0.0018
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0029	0.0059
Onchocerca volvulus		0.0063	0.0095	0.059
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0022	0.0022
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0061	0.0088	0.0088
Toxoplasma gondii	IMP dehydrogenas	0.1339	0.3736	1
Trypanosoma cruzi	GMP reductase	0.1339	0.3736	1
Brugia malayi	Inositol-1	0.0038	0.0022	0.0059
Mycobacterium ulcerans	lipase LipD	0.0037	0.0021	0.0037
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0067	0.018
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0021	0.0055
Echinococcus granulosus	dna polymerase kappa	0.004	0.0029	0.0029
Plasmodium falciparum	ataxin-2 like protein, putative	0.0053	0.0065	0.0174
Echinococcus granulosus	polycomb protein SCMH1	0.0048	0.0053	0.0053
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0191	0.0459	0.0459
Loa Loa (eye worm)	inositol-1	0.0038	0.0022	0.0059
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0094	0.0182	0.0182
Trichomonas vaginalis	set domain proteins, putative	0.05	0.1342	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0063	0.0095	0.0095
Loa Loa (eye worm)	transcription factor SMAD2	0.0238	0.0593	0.1588
Trypanosoma cruzi	inosine-5'-monophosphate dehydrogenase, putative	0.1339	0.3736	1
Loa Loa (eye worm)	thioredoxin reductase	0.0093	0.018	0.0483
Mycobacterium ulcerans	inosine 5-monophosphate dehydrogenase	0.1339	0.3736	1
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0021	0.0037
Loa Loa (eye worm)	MBCTL1	0.0055	0.0072	0.0193
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.002	0.01
Onchocerca volvulus		0.0048	0.0053	0.033
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0021	0.0026
Echinococcus granulosus	inositol monophosphatase 1	0.0038	0.0022	0.0022
Leishmania major	guanosine monophosphate reductase	0.1339	0.3736	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0032	0.0007	0.0018
Brugia malayi	ImpB/MucB/SamB family protein	0.004	0.0029	0.0077
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0032	0.0007	0.0018
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0143	0.0323	0.0323
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0063	0.0095	0.0095
Toxoplasma gondii	LsmAD domain-containing protein	0.0053	0.0065	0.0174
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0021	0.0055
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0067	0.018
Trypanosoma brucei	inosine-5'-monophosphate dehydrogenase	0.1339	0.3736	1
Echinococcus multilocularis	dna polymerase kappa	0.004	0.0029	0.0029
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0063	0.0095	0.0095
Brugia malayi	beta-lactamase family protein	0.0037	0.0021	0.0055
Echinococcus multilocularis	polycomb protein SCMH1	0.0048	0.0053	0.0053
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.004	0.0029	0.0077
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0029	0.0059
Schistosoma mansoni	terminal deoxycytidyl transferase	0.004	0.0029	0.0029
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0021	0.0021
Leishmania major	DNA polymerase kappa, putative	0.004	0.0029	0.0077
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0021	0.0021
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0032	0.0007	0.0018
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0021	0.0026
Brugia malayi	ImpB/MucB/SamB family protein	0.004	0.0029	0.0077
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0021	0.0103
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0029	0.0059
Brugia malayi	Pre-SET motif family protein	0.0439	0.1169	0.3128
Trypanosoma cruzi	PAB1-binding protein , putative	0.0053	0.0065	0.0174
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0166	0.0389	0.0389
Echinococcus granulosus	histone lysine methyltransferase setb	0.0063	0.0095	0.0095
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0029	0.0077
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0032	0.0007	0.0018
Toxoplasma gondii	aldehyde dehydrogenase	0.0069	0.0113	0.0302
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0021	0.0103
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.004	0.0029	0.0029
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0037	0.002	0.01
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0021	0.0055
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0032	0.0007	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0244	0.061	0.1634
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0032	0.0007	0.0007
Echinococcus multilocularis	tumor protein p63	0.1666	0.4668	0.4668
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0069	0.0113	0.0284
Brugia malayi	mbt repeat family protein	0.0048	0.0053	0.0141
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0021	0.0103
Brugia malayi	inosine-5'-monophosphate dehydrogenase	0.0592	0.1603	0.4291
Toxoplasma gondii	NADPH-glutathione reductase	0.0032	0.0007	0.0018

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 694295