Detailed information for compound 69467

Basic information

Technical information
  • TDR Targets ID: 69467
  • Name: 4-(6-bromo-1H-indol-3-yl)pyrimidin-2-amine
  • MW: 289.131 | Formula: C12H9BrN4
  • H donors: 2 H acceptors: 2 LogP: 2.33 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc2c(c1)[nH]cc2c1ccnc(n1)N
  • InChi: 1S/C12H9BrN4/c13-7-1-2-8-9(6-16-11(8)5-7)10-3-4-15-12(14)17-10/h1-6,16H,(H2,14,15,17)
  • InChiKey: VBPYLWZBNRFLEM-UHFFFAOYSA-N  


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Synonyms

  • 4-(6-bromo-1H-indol-3-yl)-2-pyrimidinamine
  • [4-(6-bromo-1H-indol-3-yl)pyrimidin-2-yl]amine
  • NSC714369
  • NCI60_039641

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin B2 Starlite/ChEMBL References
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A Starlite/ChEMBL References
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens protein kinase, cAMP-dependent, catalytic, gamma Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens CDC-like kinase 1 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References
Homo sapiens protein kinase, cAMP-dependent, catalytic, beta References
Homo sapiens cyclin B1 References
Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva cAMP-dependent protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania major protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Protein kinase DC2, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Theileria parva cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei protein kinase A catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Trypanosoma brucei protein lipid droplet kinase (LDK) protein kinase, cAMP-dependent, catalytic, beta 358 aa 320 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0149 0.3448 0.3448
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0077 0.0516 0.0188
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0108 0.1767 0.1483
Entamoeba histolytica protein kinase domain containing protein 0.0112 0.1936 0.5614
Trypanosoma cruzi cyclin 6, putative 0.0124 0.245 0.6597
Echinococcus granulosus dual specificity 0.0112 0.1936 0.1936
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.3448 0.3448
Leishmania major protein kinase A catalytic subunit isoform 2 0.0149 0.3448 1
Trichomonas vaginalis cyclin B, putative 0.0124 0.245 0.7106
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.1767 0.1767
Echinococcus granulosus cyclin B 0.0124 0.245 0.245
Trypanosoma cruzi cdc2-related kinase 1 0.0108 0.1767 0.4268
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0149 0.3448 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.1754 0.1469
Entamoeba histolytica cyclin, putative 0.0124 0.245 0.7106
Loa Loa (eye worm) hypothetical protein 0.0309 1 1
Trichomonas vaginalis AGC family protein kinase 0.0149 0.3448 1
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.3448 0.3448
Entamoeba histolytica hypothetical protein 0.0112 0.1936 0.5614
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0149 0.3448 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0108 0.1767 0.1767
Leishmania major protein kinase A catalytic subunit isoform 1 0.0149 0.3448 1
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 1 1
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0149 0.3448 1
Trypanosoma cruzi cdc2-related kinase 3 0.0108 0.1767 0.4268
Loa Loa (eye worm) hypothetical protein 0.0149 0.3448 0.3222
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0149 0.3448 0.3448
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.1936 0.1936
Leishmania major protein kinase A catalytic subunit 0.0149 0.3448 1
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.1767 0.5125
Echinococcus granulosus cyclin dependent kinase 0.0108 0.1767 0.1767
Trichomonas vaginalis cyclin B, putative 0.0124 0.245 0.7106
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0149 0.3448 0.3448
Echinococcus multilocularis cyclin dependent kinase 1 0.0108 0.1767 0.1767
Brugia malayi Protein kinase domain containing protein 0.0112 0.1936 0.2855
Giardia lamblia Kinase, CMGC CLK 0.0077 0.0516 0.1496
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0108 0.1767 0.4268
Entamoeba histolytica protein kinase, putative 0.0112 0.1936 0.5614
Giardia lamblia Kinase, AGC PKA 0.0149 0.3448 1
Trichomonas vaginalis cyclin B, putative 0.0124 0.245 0.7106
Trypanosoma cruzi CYC2-like cyclin, putative 0.0124 0.245 0.6597
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0112 0.1936 0.4843
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.245 0.3889
Plasmodium falciparum protein serine/threonine kinase-1 0.0077 0.0516 0.1496
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.245 0.3889
Loa Loa (eye worm) cyclin domain-containing protein 0.0199 0.5489 0.5333
Toxoplasma gondii AGC kinase 0.0149 0.3448 1
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0144 0.3266 0.3266
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0112 0.1936 0.1657
Entamoeba histolytica PH domain containing protein kinase, putative 0.0149 0.3448 1
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0149 0.3448 1
Schistosoma mansoni cyclin B 0.0124 0.245 0.245
Plasmodium vivax protein kinase Crk2 0.0108 0.1767 0.4268
Echinococcus multilocularis cyclin dependent kinase 1 0.0108 0.1767 0.1767
Echinococcus granulosus cyclin dependent kinase 5 0.0108 0.1767 0.1767
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0112 0.1936 0.4843
Plasmodium falciparum protein kinase 5 0.0108 0.1767 0.5125
Loa Loa (eye worm) hypothetical protein 0.0124 0.245 0.2189
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0149 0.3448 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0199 0.5489 0.5489
Loa Loa (eye worm) AGC/PKA protein kinase 0.0149 0.3448 0.3222
Trichomonas vaginalis cyclins, putative 0.0075 0.0457 0.1325
Trichomonas vaginalis cyclins, putative 0.0124 0.245 0.7106
Toxoplasma gondii AGC kinase 0.0149 0.3448 1
Trypanosoma brucei cdc2-related kinase 1 0.0108 0.1767 0.4268
Leishmania major cyclin 0.0124 0.245 0.6597
Echinococcus multilocularis cyclin B 0.0124 0.245 0.245
Echinococcus granulosus hypothetical protein 0.0072 0.0334 0.0334
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0149 0.3448 0.3448
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0149 0.3448 1
Echinococcus multilocularis dual specificity protein kinase clk2 0.0077 0.0516 0.0516
Trypanosoma cruzi cyclin, putative 0.0124 0.245 0.6597
Entamoeba histolytica cell division protein kinase 2, putative 0.0108 0.1767 0.5125
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.1767 0.5125
Trypanosoma cruzi cdc2-related kinase 3 0.0108 0.1767 0.4268
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0124 0.245 0.6597
Entamoeba histolytica cell division protein kinase 2, putative 0.0108 0.1767 0.5125
Trypanosoma brucei cdc2-related kinase 3 0.0108 0.1767 0.4268
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0516 0.1496
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0149 0.3448 0.3448
Echinococcus granulosus dual specificity protein kinase clk2 0.0077 0.0516 0.0516
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0149 0.3448 1
Brugia malayi Protein kinase domain containing protein 0.0108 0.1767 0.2516
Brugia malayi hypothetical protein 0.0148 0.3418 0.5835
Trichomonas vaginalis cyclins, putative 0.0124 0.245 0.7106
Trypanosoma cruzi cyclin, putative 0.0124 0.245 0.6597
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0149 0.3448 1
Echinococcus granulosus cyclin dependent kinase 1 0.0108 0.1767 0.1767
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0149 0.3448 0.3448
Trichomonas vaginalis cyclins, putative 0.0124 0.245 0.7106
Schistosoma mansoni serine/threonine protein kinase 0.0149 0.3448 0.3448
Schistosoma mansoni cyclin B3 0.0199 0.5489 0.5489
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0108 0.1767 0.1483
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0108 0.1767 0.4268
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0516 0.0516
Trichomonas vaginalis cyclins, putative 0.0124 0.245 0.7106
Loa Loa (eye worm) hypothetical protein 0.0103 0.1585 0.1295
Trichomonas vaginalis cyclin B, putative 0.0124 0.245 0.7106
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0108 0.1767 0.1767
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0149 0.3448 1
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0149 0.3448 0.5896
Trypanosoma cruzi cdc2-related kinase 1 0.0108 0.1767 0.4268
Loa Loa (eye worm) hypothetical protein 0.0148 0.3418 0.3191
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.1767 0.1767
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0144 0.3266 0.3266
Echinococcus multilocularis dual specificity 0.0112 0.1936 0.1936
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0112 0.1936 0.4843
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0149 0.3448 0.3448
Entamoeba histolytica protein kinase, putative 0.0112 0.1936 0.5614
Entamoeba histolytica PH domain containing protein kinase, putative 0.0149 0.3448 1
Loa Loa (eye worm) AGC/PKA protein kinase 0.0149 0.3448 0.3222
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0108 0.1767 0.1483
Onchocerca volvulus 0.0124 0.245 0.5
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0112 0.1936 0.4843
Giardia lamblia Kinase, CMGC CDK 0.0108 0.1767 0.5125
Loa Loa (eye worm) hypothetical protein 0.0124 0.245 0.2189
Trichomonas vaginalis CMGC family protein kinase 0.0108 0.1767 0.5125
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.5489 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.3418 0.3191
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0108 0.1767 0.4268
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0199 0.5489 0.5489
Trichomonas vaginalis cyclin A, putative 0.0124 0.245 0.7106
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 1 1
Echinococcus multilocularis cyclin dependent kinase 0.0108 0.1767 0.1767
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0149 0.3448 1
Brugia malayi cell division control protein 2 homolog 0.0108 0.1767 0.2516
Trypanosoma brucei mitotic cyclin 6 0.0124 0.245 0.6597
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0516 0.0516
Loa Loa (eye worm) hypothetical protein 0.0107 0.1754 0.1469
Giardia lamblia G2/mitotic-specific cyclin B 0.0124 0.245 0.7106
Echinococcus multilocularis 0.0072 0.0334 0.0334
Giardia lamblia Kinase, CMGC CDK 0.0108 0.1767 0.5125

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.728 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.723 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.704 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.677 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.664 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.626 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.599 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.534 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.487 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.462 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.458 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 0.12 uM Inhibition of human recombinant GST-tagged CLK1 using GRSRSRSRSRSR as substrate ChEMBL. 21623630
IC50 (binding) = 0.13 uM Inhibition of rat recombinant GST-tagged DYRK1A using myelin protein as substrate and [gamma32]-ATP after 30 mins by scintillation counting ChEMBL. 21623630
IC50 (binding) = 0.8 uM Inhibition of PKG (protein kinase G) ChEMBL. 15026054
IC50 (binding) = 1 uM Inhibition of PKA (protein kinase A) ChEMBL. 15026054
IC50 (binding) = 1 uM Inhibition of PKA (protein kinase A) ChEMBL. 15026054
IC50 (binding) = 1.2 uM Inhibition of human recombinant CDK5/p25 using Histone H1 and [gamma32]-ATP after 30 mins by scintillation counting ChEMBL. 21623630
IC50 (binding) = 2.5 uM Inhibition of glycogen synthase kinase-3 beta ChEMBL. 15026054
IC50 (binding) = 2.5 uM Inhibition of glycogen synthase kinase-3 beta ChEMBL. 15026054
IC50 (binding) = 5.5 uM Inhibition of human Cyclin-dependent kinase 5-p35nck5a ChEMBL. 15026054
IC50 (binding) = 5.5 uM Inhibition of human Cyclin-dependent kinase 5-p35nck5a ChEMBL. 15026054
IC50 (functional) = 7.3 uM Inhibition of Hep-2 human larynx carcinoma cell proliferation ChEMBL. 15026054
IC50 (functional) = 7.3 uM Inhibition of Hep-2 human larynx carcinoma cell proliferation ChEMBL. 15026054
IC50 (binding) = 13 uM Inhibition of cyclin-dependent kinase 1-cyclin B ChEMBL. 15026054
IC50 (binding) = 13 uM Inhibition of cyclin-dependent kinase 1-cyclin B ChEMBL. 15026054
IC50 (functional) = 16.9 uM Inhibition of U937 cell proliferation ChEMBL. 15026054
IC50 (functional) = 16.9 uM Inhibition of U937 cell proliferation ChEMBL. 15026054
IC50 (functional) = 21.7 uM Inhibition of RD rhabdomyocarcinoma cell proliferation ChEMBL. 15026054
IC50 (functional) = 21.7 uM Inhibition of RD rhabdomyocarcinoma cell proliferation ChEMBL. 15026054
IC50 (functional) > 25 uM Antiproliferative activity against human MCF7 cells after 48 hrs by resazurin reduction test ChEMBL. 21623630
IC50 (functional) > 25 uM Antiproliferative activity against human IMR32 cells by MTS reduction assay ChEMBL. 21623630
IC50 (functional) > 25 uM Antiproliferative activity against human SH-SY5Y cells by MTS reduction assay ChEMBL. 21623630
IC50 (ADMET) > 25 uM Antiproliferative activity against mouse HT22 cells by MTS reduction assay ChEMBL. 21623630
IC50 (functional) = 33.9 uM Inhibition of LMM3 cell proliferation (derived from the BALB/c transplantable mammaryadenocarcinoma MM3) in human ChEMBL. 15026054
IC50 (functional) = 36.6 uM Inhibition of HT-29 colon carcinoma cell proliferation ChEMBL. 15026054
IC50 (functional) = 36.6 uM Inhibition of HT-29 colon carcinoma cell proliferation ChEMBL. 15026054
IC50 (functional) = 42 uM Inhibition of PTP foreskin fibroblast cell proliferation ChEMBL. 15026054
IC50 (binding) = 100 uM Inhibition of Casein kinase I (CK1) ChEMBL. 15026054
IC50 (binding) = 100 uM Inhibition of Casein kinase I (CK1) ChEMBL. 15026054

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 15026054

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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