Detailed information for compound 703503

Basic information

Technical information
  • TDR Targets ID: 703503
  • Name: 2-[3-[2-[(2,4-difluorophenyl)amino]-2-oxoethy l]sulfonylindol-1-yl]-N,N-diethylacetamide
  • MW: 463.498 | Formula: C22H23F2N3O4S
  • H donors: 1 H acceptors: 4 LogP: 3.26 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)Cn1cc(c2c1cccc2)S(=O)(=O)CC(=O)Nc1ccc(cc1F)F)CC
  • InChi: 1S/C22H23F2N3O4S/c1-3-26(4-2)22(29)13-27-12-20(16-7-5-6-8-19(16)27)32(30,31)14-21(28)25-18-10-9-15(23)11-17(18)24/h5-12H,3-4,13-14H2,1-2H3,(H,25,28)
  • InChiKey: WOBBWOMVLZCIPH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[3-[2-[(2,4-difluorophenyl)amino]-2-oxo-ethyl]sulfonylindol-1-yl]-N,N-diethyl-acetamide
  • 2-[3-[2-[(2,4-difluorophenyl)amino]-2-oxoethyl]sulfonyl-1-indolyl]-N,N-diethylacetamide
  • 2-[3-[2-[(2,4-difluorophenyl)amino]-2-keto-ethyl]sulfonylindol-1-yl]-N,N-diethyl-acetamide
  • 2-[3-[2-[(2,4-difluorophenyl)amino]-2-oxo-ethyl]sulfonylindol-1-yl]-N,N-diethyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi 6-phosphofructokinase 0.0117 0.2406 0.5377
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0783 0.1175
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0578 0.0633
Trichomonas vaginalis ran, putative 0.0021 0.0311 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.013 0.0255
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.025 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.1438 0.413
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0696 0.0764
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0578 0.0414
Trypanosoma brucei glucose transporter, putative 0.0033 0.0576 0.0855
Schistosoma mansoni sugar transporter 0.0015 0.0179 0.0171
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0578 0.0414
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.054 0.1917
Entamoeba histolytica hypothetical protein 0.0024 0.0373 0.0568
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0577 0.0628
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0578 0.0414
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.1438 0.2832
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0018 0.0254 0.0507
Trypanosoma brucei metacaspase 5, putative 0.0018 0.0254 0.0357
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0669 0.0777
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.054 0.1064
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0552 0.06
Brugia malayi Sugar transporter family protein 0.0015 0.0179 0.0337
Loa Loa (eye worm) hypothetical protein 0.0013 0.0127 0.0149
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.1059 0.1396
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.054 0.0375
Mycobacterium tuberculosis Conserved protein 0.0072 0.1438 0.1282
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.2406 0.4736
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.2406 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0254 0.05
Schistosoma mansoni cpg binding protein 0.006 0.1156 0.1293
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.1438 0.1282
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0669 0.0777
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0311 0.0137
Loa Loa (eye worm) hypothetical protein 0.0015 0.0179 0.0229
Brugia malayi beta-lactamase 0.0072 0.1438 0.3188
Schistosoma mansoni caspase-7 (C14 family) 0.0018 0.0254 0.0257
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.1438 0.1617
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.1438 0.1282
Toxoplasma gondii ABC1 family protein 0.0072 0.1438 0.1999
Mycobacterium tuberculosis Conserved protein 0.0072 0.1438 0.1282
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1438 0.2832
Mycobacterium ulcerans hypothetical protein 0.0072 0.1438 0.413
Trypanosoma brucei metacaspase 0.0018 0.0254 0.0357
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0311 0.0636
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.025 0.0351
Plasmodium falciparum importin beta, putative 0.0029 0.0477 0.0309
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0181 0.0173
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.025 0.0338
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0254 0.0119
Loa Loa (eye worm) hypothetical protein 0.0015 0.0179 0.0229
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.013 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.013 0.0255
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0311 0.0432
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.2406 1
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.0254 0.0119
Loa Loa (eye worm) hypothetical protein 0.0029 0.0477 0.0686
Loa Loa (eye worm) hypothetical protein 0.0015 0.0179 0.0229
Echinococcus granulosus solute carrier family 22 0.0015 0.0179 0.0171
Echinococcus granulosus solute carrier family 22 0.0015 0.0179 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0576 0.1134
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.1942 0.4328
Schistosoma mansoni ap endonuclease 0.0018 0.025 0.0253
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.1059 0.1396
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0254 0.05
Loa Loa (eye worm) hypothetical protein 0.0061 0.1196 0.179
Schistosoma mansoni cpg binding protein 0.006 0.1156 0.1293
Trypanosoma brucei glucose transporter, putative 0.0033 0.0576 0.0855
Mycobacterium leprae Probable lipase LipE 0.0072 0.1438 0.5421
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.054 0.0375
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.025 1
Loa Loa (eye worm) sugar transporter 0.0015 0.0179 0.0229
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0373 0.0846
Brugia malayi MH2 domain containing protein 0.0121 0.2496 0.5581
Trypanosoma brucei glucose transporter 2A 0.0033 0.0576 0.0855
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0576 0.0855
Echinococcus multilocularis solute carrier family 22 0.0015 0.0179 0.0171
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0577 0.0628
Plasmodium vivax metacaspase 1, putative 0.0018 0.0254 0.0078
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.1059 0.158
Echinococcus granulosus solute carrier family 22 0.0015 0.0179 0.0171
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0424 0.0605
Plasmodium falciparum protein kinase 7 0.0302 0.6478 0.6546
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0294 0.0117
Entamoeba histolytica protein kinase, putative 0.0033 0.0577 0.1518
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0254 0.05
Trypanosoma brucei metacaspase MCA2 0.0018 0.0254 0.0357
Plasmodium vivax importin-beta 2, putative 0.0029 0.0477 0.0309
Schistosoma mansoni hypothetical protein 0.0039 0.0696 0.0764
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.2406 0.7109
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0532 0.0561
Loa Loa (eye worm) sugar transporter 0.0107 0.2192 0.332
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0173 0.3645 0.3602
Echinococcus multilocularis snurportin 1 0.0305 0.6541 0.7475
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.054 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0254 0.05
Echinococcus multilocularis musashi 0.0026 0.0424 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.013 0.0255
Leishmania major glucose transporter, lmgt2 0.0033 0.0576 0.063
Loa Loa (eye worm) hypothetical protein 0.0072 0.1438 0.2163
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0552 0.1225
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0179 0.025
Echinococcus multilocularis cpg binding protein 0.006 0.1156 0.1293
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.025 0.0074
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0179 0.0337
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0477 0.0701
Brugia malayi Sugar transporter family protein 0.0107 0.2192 0.4893
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.6483 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0311 0.0445
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0578 0.0414
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0256 0.0347
Schistosoma mansoni ran 0.0021 0.0311 0.0323
Loa Loa (eye worm) hypothetical protein 0.0015 0.0179 0.0229
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.2406 0.3687
Plasmodium vivax hypothetical protein, conserved 0.0072 0.1438 0.1309
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0179 0.0353
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0311 0.0323
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.6483 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.1438 0.1282
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0311 0.0209
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0424 0.0605
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0358 0.0284
Loa Loa (eye worm) hypothetical protein 0.0015 0.0179 0.0229
Trichomonas vaginalis esterase, putative 0.0072 0.1438 0.2832
Mycobacterium ulcerans beta-lactamase 0.0072 0.1438 0.413
Brugia malayi Pre-SET motif family protein 0.021 0.4448 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0173 0.3645 0.5503
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0552 0.1402
Schistosoma mansoni protein kinase 0.0033 0.0577 0.0628
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0179 0.0229
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.1438 0.1617
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0552 0.06
Loa Loa (eye worm) hypothetical protein 0.0018 0.0254 0.0344
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.1059 0.1396
Brugia malayi beta-lactamase family protein 0.0072 0.1438 0.3188
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2192 0.2482
Loa Loa (eye worm) hypothetical protein 0.0015 0.0179 0.0229
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.1438 0.3188
Loa Loa (eye worm) hypothetical protein 0.0015 0.0179 0.0229
Loa Loa (eye worm) hypothetical protein 0.0015 0.0179 0.0229
Leishmania major GTP-binding protein, putative 0.0021 0.0311 0.0209
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.025 0.0113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1942 0.2195
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0373 0.0307
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0256 0.026
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.1059 0.1603
Loa Loa (eye worm) hypothetical protein 0.0032 0.0552 0.0802
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0669 0.0509
Echinococcus multilocularis lamin dm0 0.0026 0.0424 0.0452
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0552 0.1182
Trypanosoma cruzi metacaspase, putative 0.0018 0.0254 0.0119
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0576 0.1134
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.6483 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0311 0.0282
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.1059 0.2085
Plasmodium falciparum protein kinase 6 0.0454 0.9801 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0696 0.0764
Schistosoma mansoni hypothetical protein 0.0166 0.3499 0.3982
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0127 0.0111
Schistosoma mansoni lamin 0.0026 0.0424 0.0452
Trypanosoma cruzi hexose transporter 0.0033 0.0576 0.063
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0373 0.0393
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0254 0.05
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0577 0.0628
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0577 0.1239
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.013 0.0255
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.1438 0.1282
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0254 0.05
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0577 0.0628
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0373 0.6208
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0578 0.0633
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0532 0.0577
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.1143 0.1277
Trypanosoma brucei Metacaspase-4 0.0018 0.0254 0.0357
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0254 0.05
Echinococcus multilocularis caspase 2 0.0061 0.1196 0.1338
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0251 0.0501
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2192 0.2482
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0552 0.06
Loa Loa (eye worm) hypothetical protein 0.0026 0.0413 0.0589
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.1059 0.1181
Onchocerca volvulus 0.0238 0.508 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.054 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0179 0.0229
Schistosoma mansoni sugar transporter 0.0015 0.0179 0.0171
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0576 0.1134
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0669 0.0999
Brugia malayi RNA, U transporter 1 0.0081 0.1632 0.3627
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1942 0.2195
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.013 0.0255
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.1059 0.1181
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0179 0.0171
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.054 0.1346
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.1059 0.1397
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.1059 0.1181
Schistosoma mansoni protein kinase 0.0033 0.0577 0.0628
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0669 0.0778
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0373 0.0846
Trypanosoma cruzi metacaspase, putative 0.0018 0.0254 0.0119
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0018 0.0254 0.0257
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.013 0.0255
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0018 0.0254 0.0257
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.2406 0.3648
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.1059 0.1181
Leishmania major importin beta-1 subunit, putative 0.0023 0.0358 0.0284
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0987 0.1281
Schistosoma mansoni caspase-7 (C14 family) 0.0061 0.1196 0.1338
Onchocerca volvulus 0.0043 0.0791 0.1249
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.054 0.1064
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0576 0.063
Loa Loa (eye worm) hypothetical protein 0.0072 0.1438 0.2163
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.025 0.0072
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0256 0.026
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.013 0.0255
Plasmodium falciparum hexose transporter 0.0107 0.2192 0.2092
Trypanosoma brucei glucose transporter, putative 0.0033 0.0576 0.0855
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.025 0.0113
Trypanosoma brucei protein kinase, putative 0.0055 0.1059 0.1603
Onchocerca volvulus 0.0031 0.0532 0.0721
Entamoeba histolytica hypothetical protein 0.0039 0.0696 0.2067
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0311 0.15
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1438 0.2832
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.054 0.0375
Loa Loa (eye worm) hypothetical protein 0.0015 0.0179 0.0229
Echinococcus granulosus caspase 8 0.0018 0.0254 0.0257
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0373 0.0393
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0373 0.2199
Echinococcus multilocularis solute carrier family 22 0.0015 0.0179 0.0171
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0157 0.0288
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0373 0.0201
Entamoeba histolytica hypothetical protein 0.0039 0.0696 0.2067
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.1059 0.1396
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.054 0.1064
Echinococcus granulosus dnaJ subfamily B 0.0405 0.8741 1
Brugia malayi beta-lactamase family protein 0.0072 0.1438 0.3188
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.6483 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.013 0.0255
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1143 0.3219
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Onchocerca volvulus Cell death protein 3 homolog 0.0061 0.1196 0.2074
Brugia malayi major facilitator superfamily protein 0.0015 0.0179 0.0337
Loa Loa (eye worm) hypothetical protein 0.0015 0.0179 0.0229
Schistosoma mansoni ap endonuclease 0.0018 0.025 0.0253
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Schistosoma mansoni intermediate filament proteins 0.0026 0.0424 0.0452
Schistosoma mansoni lamin 0.0026 0.0424 0.0452
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1942 0.2195
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0127 0.0111
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2192 0.2482
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0254 0.05
Echinococcus granulosus intermediate filament protein 0.0026 0.0424 0.0452
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0051 0.0024
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0311 0.021
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0311 0.0137
Plasmodium vivax hexose transporter 0.0107 0.2192 0.2092
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.1059 0.2085
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.1438 0.1282
Loa Loa (eye worm) hypothetical protein 0.0015 0.0179 0.0229
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0577 0.0628
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.2406 0.3648
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0669 0.0777
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Schistosoma mansoni hypothetical protein 0.0405 0.8741 1
Onchocerca volvulus 0.0026 0.0424 0.05
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0373 0.054
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2192 0.2482
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0552 0.4243
Schistosoma mansoni sugar transporter 0.0015 0.0179 0.0171
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0018 0.0254 0.0257
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0578 0.0414
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Trypanosoma brucei metacaspase MCA3 0.0018 0.0254 0.0357
Loa Loa (eye worm) hypothetical protein 0.0072 0.1438 0.2163
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.013 0.0255
Loa Loa (eye worm) hypothetical protein 0.012 0.2479 0.3761
Brugia malayi phosphofructokinase 0.0117 0.2406 0.5377
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.1143 0.1277
Brugia malayi CXXC zinc finger family protein 0.0056 0.1086 0.2389
Entamoeba histolytica hypothetical protein 0.0023 0.0358 0.05
Leishmania major metacaspase, putative 0.0018 0.0254 0.0119
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0576 0.0855
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.2496 0.3787
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0373 0.0307
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0179 0.0171
Schistosoma mansoni glucose transport protein 0.0107 0.2192 0.2482
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1438 0.1998
Brugia malayi Cam kinase protein 1 0.0033 0.0577 0.1239
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0477 0.0701
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0576 0.1134
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.2406 0.2727
Toxoplasma gondii hypothetical protein 0.0049 0.092 0.1176
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.013 0.0255
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.2495 0.283
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0477 0.0513
Leishmania major hypothetical protein, conserved 0.0072 0.1438 0.1998
Loa Loa (eye worm) hypothetical protein 0.0031 0.0532 0.0772
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.025 0.0493
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.1438 0.1998
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0179 0.0171
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.2406 0.2267
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0576 0.0855
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.1059 0.1396
Trypanosoma brucei glucose transporter, putative 0.0033 0.0576 0.0855
Trypanosoma brucei glucose transporter, putative 0.0033 0.0576 0.0855
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0179 0.0337
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.025 0.0808
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.2406 0.2727
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.1059 0.2085
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0576 0.1134
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.2406 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0373 0.0393
Echinococcus granulosus geminin 0.0166 0.3499 0.3982
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.1086 0.1621
Schistosoma mansoni importin beta-1 0.0029 0.0477 0.0513
Schistosoma mansoni cpg binding protein 0.0056 0.1086 0.1212
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0578 0.0414
Entamoeba histolytica protein kinase, putative 0.0033 0.0577 0.1518
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0107 0.2192 0.2482
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.025 0.0493
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0552 0.1088
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.1438 0.2832
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0254 0.0119
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.1059 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0247 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0179 0.0353
Trypanosoma brucei glucose transporter, putative 0.0033 0.0576 0.0855
Trypanosoma brucei glucose transporter, putative 0.0033 0.0576 0.0855
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0523 0.0565
Schistosoma mansoni caspase-3 (C14 family) 0.0018 0.0254 0.0257
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0532 0.0577
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0373 0.0201
Loa Loa (eye worm) hypothetical protein 0.0012 0.0116 0.0133
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Mycobacterium leprae conserved hypothetical protein 0.0072 0.1438 0.5421
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0577 0.0857
Loa Loa (eye worm) hypothetical protein 0.0012 0.0116 0.0133
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Leishmania major glucose transporter, lmgt3 0.0033 0.0576 0.063
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0179 0.0337
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0783 0.0957
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0577 0.0628
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.1059 0.2085
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0578 0.0633
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.2215 0.3233
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0523 0.0565
Echinococcus granulosus cpg binding protein 0.006 0.1156 0.1293
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0294 0.0117
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0532 0.0577
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0138 0.0166
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1143 0.1277
Trichomonas vaginalis set domain proteins, putative 0.0238 0.508 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0107 0.2192 0.2482
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0179 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0179 0.0353
Loa Loa (eye worm) hypothetical protein 0.0043 0.0791 0.1169
Brugia malayi hypothetical protein 0.0015 0.0179 0.0337
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.1438 0.413
Loa Loa (eye worm) hypothetical protein 0.0015 0.0179 0.0229
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0179 0.0171
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.054 0.1064
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.2406 0.4736
Loa Loa (eye worm) beta-lactamase 0.0072 0.1438 0.2163
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Echinococcus granulosus snurportin 1 0.0305 0.6541 0.7475
Plasmodium vivax CDK-related protein kinase 6, putative 0.0454 0.9801 1
Brugia malayi 6-phosphofructokinase 0.0117 0.2406 0.5377
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.2406 0.4736
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.2406 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0254 0.05
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0481 0.0518
Brugia malayi hypothetical protein 0.0039 0.0696 0.1507
Echinococcus multilocularis apoptotic protease activating factor 1 0.0043 0.0791 0.0874
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0578 0.0414
Onchocerca volvulus Huntingtin homolog 0.012 0.2479 0.4694
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0578 0.0414
Echinococcus granulosus lamin dm0 0.0026 0.0424 0.0452
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.1143 0.0981
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0576 0.1134
Schistosoma mansoni hypothetical protein 0.0107 0.2192 0.2482
Brugia malayi Sugar transporter family protein 0.0015 0.0179 0.0337
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0669 0.0509
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Trypanosoma cruzi metacaspase, putative 0.0018 0.0254 0.0119
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.025 0.0498
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2192 0.2482
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.1143 0.153
Echinococcus multilocularis caspase 8 0.0018 0.0254 0.0257
Onchocerca volvulus 0.0072 0.1438 0.257
Brugia malayi hypothetical protein 0.0015 0.0179 0.0337
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0576 0.063
Schistosoma mansoni glucose transport protein 0.0107 0.2192 0.2482
Schistosoma mansoni hypothetical protein 0.0043 0.0791 0.0874
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0181 0.0173
Schistosoma mansoni glucose transporter 0.0015 0.0179 0.0171
Echinococcus multilocularis caspase 0.0018 0.0254 0.0257
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0179 0.025
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0576 0.063
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.1059 0.1396
Loa Loa (eye worm) hypothetical protein 0.0033 0.0577 0.0841
Toxoplasma gondii exonuclease III APE 0.0018 0.025 0.0113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0532 0.0577
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.2406 0.3532
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1143 0.3219
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.1438 0.219
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0532 0.0577
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.054 0.0573
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0157 0.0196
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.054 0.4105
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.6541 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.2406 0.3532
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0424 0.0892
Loa Loa (eye worm) hypothetical protein 0.0026 0.0421 0.06
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0577 0.0628
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.025 0.0253
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0532 0.0577
Loa Loa (eye worm) hypothetical protein 0.0072 0.1438 0.2163
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0254 0.05
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.013 0.0255
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.2406 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.2989 0.4591
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.1438 0.1617
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0358 0.0705
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.1438 0.2832
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.013 0.0255
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1942 0.2195
Echinococcus multilocularis lamin 0.0026 0.0424 0.0452
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.054 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0107 0.2192 0.2482
Echinococcus multilocularis geminin 0.0166 0.3499 0.3982
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0373 0.0307
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.1438 0.1282
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.025 0.0113
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0577 0.0628
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.2496 0.3787
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0179 0.0353
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0576 0.1134
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.2989 0.4458
Entamoeba histolytica hypothetical protein 0.0039 0.0696 0.2067
Leishmania major glucose transporter, lmgt1 0.0033 0.0576 0.063
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0181 0.0173
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0308 0.0607
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.2406 0.2727
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0373 0.0373
Toxoplasma gondii protein kinase, putative 0.0302 0.6478 1
Entamoeba histolytica hypothetical protein 0.0039 0.0696 0.2067
Schistosoma mansoni protein kinase 0.0033 0.0577 0.0628
Loa Loa (eye worm) hypothetical protein 0.0015 0.0179 0.0229
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0254 0.05
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0311 0.0323
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.1438 0.1617
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0179 0.0241
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Plasmodium falciparum metacaspase 1 0.0018 0.0254 0.0078
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0373 0.0393
Loa Loa (eye worm) hypothetical protein 0.0026 0.0424 0.0605
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1143 0.3219
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0696 0.0764
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0254 0.05
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0373 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0179 0.0353
Trypanosoma brucei glucose transporter, putative 0.0033 0.0576 0.0855
Schistosoma mansoni hypothetical protein 0.0305 0.6541 0.7475
Onchocerca volvulus 0.0056 0.1086 0.185
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.054 0.1064
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.054 0.0573
Echinococcus granulosus General substrate transporter 0.0092 0.1863 0.2104
Schistosoma mansoni glucose transport protein 0.0107 0.2192 0.2482
Loa Loa (eye worm) phosphofructokinase 0.0117 0.2406 0.3648
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0577 0.0841
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0358 0.0705
Echinococcus granulosus caspase 0.0018 0.0254 0.0257
Loa Loa (eye worm) hypothetical protein 0.0015 0.0179 0.0229
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.054 0.0375
Brugia malayi hypothetical protein 0.0015 0.0179 0.0337
Schistosoma mansoni sugar transporter 0.0015 0.0179 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.013 0.0255
Loa Loa (eye worm) hypothetical protein 0.0072 0.1438 0.2163
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.1942 0.2937
Trichomonas vaginalis helicase, putative 0.0013 0.013 0.0255
Plasmodium falciparum metacaspase-like protein 0.0018 0.0254 0.0078
Toxoplasma gondii facilitative glucose transporter GT1 0.0107 0.2192 0.3196
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0254 0.05
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0577 0.0841
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.013 0.0255
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.3344 0.3223
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0552 0.1182
Echinococcus granulosus apoptotic protease activating factor 1 0.0043 0.0791 0.0874
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1942 0.2195
Mycobacterium ulcerans hypothetical protein 0.0159 0.3344 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.1438 0.2163
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.054 0.1064
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.2406 0.2727
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.2406 0.4736
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0552 0.06
Trypanosoma brucei sugar transporter, putative 0.0015 0.0179 0.0241
Brugia malayi hypothetical protein 0.0043 0.0791 0.1723
Mycobacterium tuberculosis Conserved protein 0.0072 0.1438 0.1282
Brugia malayi intermediate filament protein 0.0026 0.0424 0.0892
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0254 0.05
Echinococcus granulosus lamin 0.0026 0.0424 0.0452
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0373 0.0775
Schistosoma mansoni ran 0.0021 0.0311 0.0323
Plasmodium vivax SET domain protein, putative 0.0031 0.0532 0.0367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1942 0.2195
Onchocerca volvulus 0.0072 0.1438 0.257
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.025 0.0074
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0018 0.0254 0.0119
Mycobacterium ulcerans lipase LipD 0.0072 0.1438 0.413
Echinococcus multilocularis solute carrier family 22 0.0015 0.0179 0.0171
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0254 0.0078
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0783 0.0957
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.013 0.0255
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.1438 0.2163
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.025 0.0253
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.025 0.066
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.1143 0.1528
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0358 0.0705
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0577 0.1137
Echinococcus granulosus caspase 2 0.0061 0.1196 0.1338
Plasmodium falciparum mitogen-activated protein kinase 2 0.0173 0.3645 0.3602
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0577 0.0628
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.2192 0.4315
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.2989 0.4458
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.1059 0.1181
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0179 0.0171
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.054 0.1064
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1143 0.1277
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.013 0.0255
Schistosoma mansoni hypothetical protein 0.0166 0.3499 0.3982
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0576 0.063
Trypanosoma cruzi metacaspase, putative 0.0018 0.0254 0.0119
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0783 0.0957
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0018 0.0254 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0179 0.0353
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0179 0.025
Brugia malayi hypothetical protein 0.012 0.2479 0.5544
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.8741 1
Onchocerca volvulus 0.0026 0.0424 0.05
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0179 0.0229
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0532 0.0577
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0181 0.0173
Echinococcus granulosus solute carrier family 22 0.0015 0.0179 0.0171
Brugia malayi major facilitator superfamily protein 0.0015 0.0179 0.0337
Leishmania major protein kinase, putative 0.0033 0.0577 0.0632
Brugia malayi MAP kinase sur-1 0.0055 0.1059 0.2329
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0179 0.0353
Loa Loa (eye worm) hypothetical protein 0.012 0.2479 0.3761
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1942 0.2195
Echinococcus granulosus importin subunit beta 1 0.0029 0.0477 0.0513
Brugia malayi Cell death protein 3 precursor 0.0061 0.1196 0.2638
Trypanosoma brucei glucose transporter 1E 0.0033 0.0576 0.0855
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.4448 0.6785
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0578 0.0414
Trypanosoma cruzi metacaspase 5, putative 0.0018 0.0254 0.0119
Echinococcus multilocularis solute carrier family 22 0.0015 0.0179 0.0171
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0477 0.0472
Brugia malayi Importin beta-1 subunit 0.0029 0.0477 0.1011
Loa Loa (eye worm) hypothetical protein 0.0024 0.0373 0.0526
Onchocerca volvulus 0.0072 0.1438 0.257
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Brugia malayi Pre-SET motif family protein 0.0031 0.0532 0.1137
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.1438 0.1282
Mycobacterium ulcerans sugar transporter 0.0015 0.0179 0.025
Onchocerca volvulus Huntingtin homolog 0.012 0.2479 0.4694
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0179 0.0353
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0669 0.0777
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0181 0.0173
Loa Loa (eye worm) hypothetical protein 0.0032 0.0552 0.0802
Echinococcus multilocularis General substrate transporter 0.0092 0.1863 0.2104
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0311 0.0209

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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