Detailed information for compound 726007

Basic information

Technical information
  • TDR Targets ID: 726007
  • Name: 2-(4-bromophenoxy)-1-(4-prop-2-enylpiperazin- 1-yl)butan-1-one
  • MW: 367.281 | Formula: C17H23BrN2O2
  • H donors: 0 H acceptors: 1 LogP: 3.5 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(C(=O)N1CCN(CC1)CC=C)Oc1ccc(cc1)Br
  • InChi: 1S/C17H23BrN2O2/c1-3-9-19-10-12-20(13-11-19)17(21)16(4-2)22-15-7-5-14(18)6-8-15/h3,5-8,16H,1,4,9-13H2,2H3
  • InChiKey: ZFYTXLVTLPAUMO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-allylpiperazin-1-yl)-2-(4-bromophenoxy)butan-1-one
  • 1-(4-allyl-1-piperazinyl)-2-(4-bromophenoxy)butan-1-one
  • IVK/0015691

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0151 0.0335
Leishmania major cathepsin L-like protease 0.0036 0.007 0.0084
Toxoplasma gondii ABC1 family protein 0.0148 0.0617 0.0707
Echinococcus granulosus histone acetyltransferase KAT2B 0.0158 0.0663 0.0663
Trypanosoma cruzi cysteine peptidase, putative 0.0137 0.056 0.0672
Schistosoma mansoni cathepsin F (C01 family) 0.0024 0.0012 0.0012
Echinococcus granulosus tumor protein p63 0.0691 0.3257 0.3257
Toxoplasma gondii hypothetical protein 0.0055 0.0161 0.0158
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0127 0.0152
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.0685 0.0823
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.056 0.0672
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0151 0.0335
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.007 0.0084
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0285 0.3739
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.007 0.007
Leishmania major cathepsin L-like protease 0.0137 0.056 0.0672
Leishmania major cysteine peptidase A (CPA) 0.0036 0.007 0.0084
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.0617 0.0617
Entamoeba histolytica hypothetical protein 0.0117 0.0464 0.0557
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0443 0.0984
Toxoplasma gondii thioredoxin reductase 0.0049 0.0136 0.0128
Plasmodium vivax hypothetical protein, conserved 0.0148 0.0617 0.0707
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0285 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0443 0.0984
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.007 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0617 0.0741
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.007 0.0084
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0148 0.0617 0.137
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0128 0.0118
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.0685 0.0685
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0127 0.0152
Onchocerca volvulus 0.0036 0.007 0.0069
Mycobacterium ulcerans lipase LipD 0.0148 0.0617 0.8095
Loa Loa (eye worm) cysteine protease 0.0036 0.007 0.0084
Schistosoma mansoni survival motor neuron protein 0.0097 0.0366 0.0366
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.056 0.0672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.007 0.0084
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0285 0.0285
Brugia malayi Pre-SET motif family protein 0.0233 0.103 0.1236
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0136 0.0163
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0144 0.0172
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.0015
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0505 0.8083
Giardia lamblia Pantothenate kinase 4 0.1733 0.8332 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.007 0.0084
Leishmania major pantothenate kinase subunit, putative 0.1733 0.8332 1
Schistosoma mansoni hypothetical protein 0.0117 0.0464 0.0464
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0285 0.0307
Entamoeba histolytica cysteine protease, putative 0.0036 0.007 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.056 0.0672
Plasmodium vivax glutathione reductase, putative 0.0049 0.0136 0.0128
Onchocerca volvulus 0.0101 0.0388 0.0451
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0058 0.0058
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0285 0.0285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.056 0.0672
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0338 0.1541 0.185
Brugia malayi MH2 domain containing protein 0.0126 0.0507 0.0609
Plasmodium vivax SET domain protein, putative 0.0033 0.0058 0.0034
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.056 0.0672
Loa Loa (eye worm) glutathione reductase 0.0049 0.0136 0.0163
Loa Loa (eye worm) hypothetical protein 0.0051 0.0144 0.0172
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0136 0.0163
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0127 0.0152
Mycobacterium leprae conserved hypothetical protein 0.0148 0.0617 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0058 0.0058
Brugia malayi Pre-SET motif family protein 0.0033 0.0058 0.007
Leishmania major cathepsin L-like protease 0.0036 0.007 0.0084
Toxoplasma gondii pantothenate kinase 0.0732 0.3459 0.4131
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0058 0.0058
Trichomonas vaginalis pantothenate kinase, putative 0.1733 0.8332 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0148 0.0617 0.0617
Brugia malayi cathepsin L-like precursor 0.0024 0.0012 0.0015
Mycobacterium tuberculosis Conserved protein 0.0148 0.0617 0.137
Echinococcus multilocularis survival motor neuron protein 1 0.0474 0.2203 0.2203
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.056 0.0672
Mycobacterium tuberculosis Conserved protein 0.0148 0.0617 0.137
Brugia malayi Cathepsin L-like precursor 0.0036 0.007 0.0084
Leishmania major trypanothione reductase 0.0049 0.0136 0.0163
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0151 0.2062
Trypanosoma brucei pantothenate kinase subunit, putative 0.1733 0.8332 1
Schistosoma mansoni hypothetical protein 0.0097 0.0366 0.0366
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.056 0.0672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0012 0.0015
Brugia malayi Probable ClpP-like protease 0.008 0.0285 0.0342
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0033 0.0058 0.007
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.007 0.0084
Onchocerca volvulus 0.0036 0.007 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.007 0.0084
Onchocerca volvulus 0.0033 0.0058 0.0055
Trypanosoma cruzi cysteine peptidase, putative 0.0137 0.056 0.0672
Brugia malayi Thioredoxin reductase 0.0049 0.0136 0.0163
Trichomonas vaginalis esterase, putative 0.0148 0.0617 0.0741
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.0617 0.0741
Loa Loa (eye worm) hypothetical protein 0.0148 0.0617 0.0741
Trypanosoma cruzi cysteine peptidase, putative 0.0036 0.007 0.0084
Onchocerca volvulus 0.0148 0.0617 0.0727
Mycobacterium ulcerans beta-lactamase 0.0148 0.0617 0.8095
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0178 0.0213
Brugia malayi hypothetical protein 0.0117 0.0464 0.0557
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.0685 0.0685
Plasmodium falciparum pantothenate kinase 1, putative 0.1733 0.8332 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.007 0.0084
Trichomonas vaginalis pantothenate kinase, putative 0.1733 0.8332 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0128 0.0154
Entamoeba histolytica hypothetical protein 0.0117 0.0464 0.0557
Plasmodium vivax vivapain-2 0.0036 0.007 0.0049
Trichomonas vaginalis pantothenate kinase, putative 0.1733 0.8332 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0617 0.0741
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.007 0.0084
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0285 0.0307
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0285 1
Onchocerca volvulus Cathepsin F homolog 0.0036 0.007 0.0069
Loa Loa (eye worm) acetyltransferase 0.0162 0.0685 0.0823
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0947 0.4505 1
Plasmodium falciparum glutathione reductase 0.0049 0.0136 0.0128
Trypanosoma brucei trypanothione reductase 0.0049 0.0136 0.0163
Onchocerca volvulus 0.0036 0.007 0.0069
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0128 0.0154
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0285 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0065 0.0078
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0144 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.007 0.0084
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0125 0.0503 0.0603
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0117 0.0464 0.0464
Echinococcus multilocularis cysteine protease 0.0036 0.007 0.007
Brugia malayi Cathepsin L-like precursor 0.0024 0.0012 0.0015
Loa Loa (eye worm) beta-lactamase 0.0148 0.0617 0.0741
Trypanosoma cruzi pantothenate kinase subunit, putative 0.1733 0.8332 1
Mycobacterium tuberculosis Probable hydrolase 0.0148 0.0617 0.137
Loa Loa (eye worm) hypothetical protein 0.0169 0.0719 0.0863
Onchocerca volvulus 0.0036 0.007 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.007 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.007 0.0084
Onchocerca volvulus 0.0036 0.007 0.0069
Brugia malayi Cathepsin L-like cysteine proteinase 0.0024 0.0012 0.0015
Toxoplasma gondii fumble protein 0.1733 0.8332 1
Brugia malayi Cathepsin L-like precursor 0.0036 0.007 0.0084
Schistosoma mansoni microtubule-associated protein tau 0.2076 1 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0285 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0137 0.056 0.0672
Onchocerca volvulus 0.0148 0.0617 0.0727
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.056 0.0672
Echinococcus multilocularis cysteine protease 0.0036 0.007 0.007
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0136 0.0136
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0148 0.0617 0.137
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0058 0.0034
Mycobacterium tuberculosis Conserved hypothetical protein 0.0178 0.0762 0.1692
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0058 0.0058
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0117 0.0464 0.0464
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0128 0.0128
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0036 0.007 0.0084
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.007 0.007
Plasmodium vivax vivapain-2 0.0036 0.007 0.0049
Mycobacterium tuberculosis Probable lipase LipD 0.0148 0.0617 0.137
Mycobacterium tuberculosis Probable esterase LipL 0.0148 0.0617 0.137
Loa Loa (eye worm) hypothetical protein 0.008 0.0285 0.0342
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0507 0.0609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.007 0.0084
Leishmania major cathepsin L-like protease 0.0137 0.056 0.0672
Trypanosoma cruzi major cysteine proteinase, putative 0.0107 0.0418 0.0502
Plasmodium falciparum thioredoxin reductase 0.0049 0.0136 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.007 0.0084
Entamoeba histolytica hypothetical protein 0.0117 0.0464 0.0557
Schistosoma mansoni pantothenate kinase 0.1733 0.8332 0.8332
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0338 0.1541 0.185
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0148 0.0617 0.137
Leishmania major cathepsin L-like protease 0.0036 0.007 0.0084
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0136 0.0128
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0443 0.0984
Brugia malayi beta-lactamase family protein 0.0148 0.0617 0.0741
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0505 0.112
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.007 0.0084
Trichomonas vaginalis set domain proteins, putative 0.0265 0.1186 0.1424
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0617 0.0741
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.056 0.0672
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.0388 0.0388
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.0617 0.0741
Onchocerca volvulus Cathepsin L homolog 0.0036 0.007 0.0069
Onchocerca volvulus 0.0036 0.007 0.0069
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.016 0.0674 0.081
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0144 0.0172
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0127 0.0152
Schistosoma mansoni pantothenate kinase 0.1733 0.8332 0.8332
Entamoeba histolytica pantothenate kinase 1, putative 0.1733 0.8332 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.007 0.0084
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.016 0.0674 0.081
Loa Loa (eye worm) hypothetical protein 0.0148 0.0617 0.0741
Echinococcus granulosus cathepsin l1 0.0036 0.007 0.007
Echinococcus granulosus survival motor neuron protein 1 0.0474 0.2203 0.2203
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.007 0.0084
Leishmania major cathepsin L-like protease 0.0137 0.056 0.0672
Schistosoma mansoni transcription factor LCR-F1 0.0117 0.0464 0.0464
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.007 0.0084
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0617 0.0741
Loa Loa (eye worm) hypothetical protein 0.0148 0.0617 0.0741
Brugia malayi Cathepsin L-like precursor 0.0036 0.007 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.056 0.0672
Echinococcus granulosus cathepsin l1 0.0024 0.0012 0.0012
Trypanosoma cruzi cysteine peptidase, putative 0.0137 0.056 0.0672
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0128 0.0118
Onchocerca volvulus 0.0036 0.007 0.0069
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.016 0.0674 0.081
Leishmania major hypothetical protein, conserved 0.0148 0.0617 0.0741
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0148 0.0617 0.0741
Plasmodium vivax hypothetical protein, conserved 0.0732 0.3459 0.4131
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0366 0.044
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0443 0.7043
Brugia malayi glutathione reductase 0.0049 0.0136 0.0163
Echinococcus granulosus cathepsin l cysteine peptidase 0.0036 0.007 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.007 0.0084
Mycobacterium tuberculosis Probable reductase 0.0113 0.0443 0.0984
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0109 0.013
Loa Loa (eye worm) hypothetical protein 0.0101 0.0388 0.0465
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.0617 0.0741
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0024 0.0012 0.0015
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0505 0.112
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0109 0.0095
Brugia malayi Cathepsin L-like precursor 0.0024 0.0012 0.0015
Mycobacterium ulcerans hypothetical protein 0.0148 0.0617 0.8095
Loa Loa (eye worm) hypothetical protein 0.0148 0.0617 0.0741
Mycobacterium ulcerans esterase/lipase LipP 0.0148 0.0617 0.8095
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0036 0.007 0.0049
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0109 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.007 0.0084
Echinococcus multilocularis microtubule associated protein 2 0.2076 1 1
Brugia malayi pantothenate kinase family protein 0.1733 0.8332 1
Leishmania major cathepsin L-like protease 0.0036 0.007 0.0084
Echinococcus multilocularis pantothenate kinase 4 0.1733 0.8332 0.8332
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.007 0.0084
Echinococcus multilocularis beta LACTamase domain containing family member 0.0148 0.0617 0.0617
Trypanosoma cruzi pantothenate kinase subunit, putative 0.1733 0.8332 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0285 0.4346
Entamoeba histolytica hypothetical protein 0.0117 0.0464 0.0557
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0058 0.0058
Entamoeba histolytica cysteine proteinase, putative 0.0024 0.0012 0.0015
Onchocerca volvulus Fumble homolog 0.1733 0.8332 1
Mycobacterium tuberculosis Conserved protein 0.0148 0.0617 0.137
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0036 0.007 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.007 0.0084
Plasmodium falciparum cysteine proteinase falcipain 3 0.0036 0.007 0.0049
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0338 0.1541 0.185
Brugia malayi hypothetical protein 0.0169 0.0719 0.0863
Echinococcus granulosus pantothenate kinase 4 0.1733 0.8332 0.8332
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0148 0.0617 0.8095
Leishmania major mitochondrial DNA polymerase beta 0.0338 0.1541 0.185
Trichomonas vaginalis conserved hypothetical protein 0.1001 0.4768 0.5723
Trichomonas vaginalis pantothenate kinase, putative 0.1733 0.8332 1
Mycobacterium ulcerans hypothetical protein 0.0178 0.0762 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0285 0.3739
Brugia malayi hypothetical protein 0.0474 0.2203 0.2644
Brugia malayi Cathepsin L-like precursor 0.0036 0.007 0.0084
Loa Loa (eye worm) hypothetical protein 0.0148 0.0617 0.0741
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0285 0.0307
Trypanosoma brucei hypothetical protein, conserved 0.0148 0.0617 0.0741
Echinococcus granulosus cathepsin L cysteine proteinase 0.0036 0.007 0.007
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0285 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.007 0.0084
Plasmodium falciparum pantothenate kinase 2, putative 0.0732 0.3459 0.4131
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.007 0.0084
Toxoplasma gondii cathepsin CPL 0.0036 0.007 0.0049
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0136 0.0136
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0128 0.0118
Brugia malayi Cathepsin L-like precursor 0.0036 0.007 0.0084
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0505 0.112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.056 0.0672
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0151 0.0151
Loa Loa (eye worm) fibroinase 0.0036 0.007 0.0084
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0052 0.0052
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.007 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.007 0.0084
Schistosoma mansoni hypothetical protein 0.0035 0.0065 0.0065
Entamoeba histolytica cysteine proteinase, putative 0.0036 0.007 0.0084
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0443 0.0984
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0065 0.0078
Loa Loa (eye worm) pantothenate kinase 0.1733 0.8332 1
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.007 0.007
Mycobacterium leprae Probable lipase LipE 0.0148 0.0617 1
Mycobacterium tuberculosis Probable lipase LipE 0.0148 0.0617 0.137
Brugia malayi beta-lactamase 0.0148 0.0617 0.0741
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0507 0.0609
Loa Loa (eye worm) ctsf protein 0.0036 0.007 0.0084
Onchocerca volvulus 0.0097 0.0366 0.0425
Plasmodium vivax pantothenate kinase, putative 0.1733 0.8332 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.007 0.0084
Onchocerca volvulus 0.0169 0.0719 0.0849
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0285 0.0285
Brugia malayi beta-lactamase family protein 0.0148 0.0617 0.0741
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0148 0.0617 0.0741
Loa Loa (eye worm) hypothetical protein 0.0024 0.0012 0.0015
Onchocerca volvulus 0.0265 0.1186 0.1411
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.103 0.1236
Trichomonas vaginalis pantothenate kinase, putative 0.1733 0.8332 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0443 0.0984
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.007 0.007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.0617 0.0617
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.007 0.0084
Echinococcus multilocularis tumor protein p63 0.0691 0.3257 0.3257
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0151 0.0151
Onchocerca volvulus Cathepsin L homolog 0.0036 0.007 0.0069
Onchocerca volvulus 0.0148 0.0617 0.0727
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0136 0.0301
Leishmania major cathepsin L-like protease 0.0036 0.007 0.0084
Loa Loa (eye worm) hypothetical protein 0.0036 0.007 0.0084
Loa Loa (eye worm) hypothetical protein 0.0474 0.2203 0.2644
Brugia malayi Cathepsin L-like precursor 0.0036 0.007 0.0084
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.0617 0.0741
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.007 0.0084

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.