Detailed information for compound 726943

Basic information

Technical information
  • TDR Targets ID: 726943
  • Name: 4-bromo-N-methyl-N-[(3-pyridin-4-yl-1,2,4-oxa diazol-5-yl)methyl]benzenesulfonamide
  • MW: 409.258 | Formula: C15H13BrN4O3S
  • H donors: 0 H acceptors: 5 LogP: 2.1 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)S(=O)(=O)N(Cc1onc(n1)c1ccncc1)C
  • InChi: 1S/C15H13BrN4O3S/c1-20(24(21,22)13-4-2-12(16)3-5-13)10-14-18-15(19-23-14)11-6-8-17-9-7-11/h2-9H,10H2,1H3
  • InChiKey: XZOJWWPXJOCSNF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-bromo-N-methyl-N-[[3-(4-pyridyl)-1,2,4-oxadiazol-5-yl]methyl]benzenesulfonamide
  • ZINC01065792
  • CBKinase1_012129
  • 4-bromo-N-methyl-N-{[3-(4-pyridinyl)-1,2,4-oxadiazol-5-yl]methyl}benzenesulfonamide
  • MLS000052450
  • SMR000081853
  • CBKinase1_024529
  • STK322707

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0489 0.0489
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0486 0.0486
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0699 0.1008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0402 0.081
Entamoeba histolytica cysteine proteinase, putative 0.0018 0 0.5
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.1942 0.3965
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0231 0.0231
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.2304 0.2304
Loa Loa (eye worm) hypothetical protein 0.0034 0.0231 0.045
Echinococcus multilocularis GPCR, family 2 0.0034 0.0231 0.0231
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0093 0.0093
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0093 0.0181
Leishmania major cathepsin L-like protease 0.0068 0.0699 0.1427
Loa Loa (eye worm) hypothetical protein 0.0038 0.0286 0.0557
Loa Loa (eye worm) intermediate filament protein 0.0052 0.0481 0.0936
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.1267 0.2468
Leishmania major mitochondrial DNA polymerase beta 0.0332 0.438 0.8943
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0399 0.0777
Leishmania major hypothetical protein, conserved 0.0038 0.0286 0.0584
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0489 0.0489
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0286 0.0286
Trichomonas vaginalis esterase, putative 0.0038 0.0286 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0093 0.0093
Brugia malayi beta-lactamase 0.0038 0.0286 0.0557
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0386 0.5134 1
Toxoplasma gondii ABC1 family protein 0.0038 0.0286 0.5746
Brugia malayi AMP-binding enzyme family protein 0.0386 0.5134 1
Brugia malayi intermediate filament protein 0.0052 0.0481 0.0936
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0332 0.438 1
Echinococcus granulosus GPCR family 2 0.0034 0.0231 0.0231
Onchocerca volvulus 0.0038 0.0286 0.1335
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0286 0.0557
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.1942 0.391
Loa Loa (eye worm) hypothetical protein 0.0109 0.1267 0.2468
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.3168 0.6249
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0052 0.0481 0.0936
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0286 0.0286
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0399 0.0399
Schistosoma mansoni smad 0.0025 0.0093 0.0093
Brugia malayi MH2 domain containing protein 0.0025 0.0093 0.0181
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0399 0.1862
Echinococcus granulosus smad 0.0025 0.0093 0.0093
Loa Loa (eye worm) MH2 domain-containing protein 0.036 0.4767 0.9284
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.3648 0.7106
Echinococcus multilocularis microtubule associated protein 2 0.0736 1 1
Schistosoma mansoni Smad4 0.0025 0.0093 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0286 0.0576
Schistosoma mansoni microtubule-associated protein tau 0.0736 1 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0486 0.0946
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0521 0.1015
Schistosoma mansoni lamin 0.0052 0.0481 0.0481
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0699 0.1407
Onchocerca volvulus 0.0172 0.2143 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0521 0.0521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0699 0.1008
Loa Loa (eye worm) transcription factor SMAD2 0.036 0.4767 0.9284
Loa Loa (eye worm) hypothetical protein 0.0053 0.0489 0.0952
Brugia malayi hypothetical protein 0.0172 0.2143 0.4174
Echinococcus granulosus Smad4 0.0025 0.0093 0.0093
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0286 0.0286
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0399 0.0399
Schistosoma mansoni smad1 5 8 and 0.0025 0.0093 0.0093
Entamoeba histolytica cysteine proteinase, putative 0.0018 0 0.5
Schistosoma mansoni hypothetical protein 0.015 0.1842 0.1842
Loa Loa (eye worm) hypothetical protein 0.0046 0.0399 0.0777
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0699 0.1008
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0399 0.0399
Echinococcus multilocularis tumor protein p63 0.036 0.477 0.477
Schistosoma mansoni smad1 5 8 and 0.0025 0.0093 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0699 0.1008
Onchocerca volvulus 0.0052 0.0481 0.2242
Schistosoma mansoni hypothetical protein 0.0034 0.0231 0.0231
Schistosoma mansoni hypothetical protein 0.0034 0.0231 0.0231
Echinococcus multilocularis smad 0.0025 0.0093 0.0093
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0093 0.0181
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0231 0.0231
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0052 0.0481 0.0936
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0521 0.0521
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.1267 0.2468
Echinococcus granulosus intermediate filament protein 0.0052 0.0481 0.0481
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0 0.5
Leishmania major cathepsin L-like protease 0.0068 0.0699 0.1427
Echinococcus granulosus lamin dm0 0.0052 0.0481 0.0481
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0521 0.1015
Loa Loa (eye worm) hypothetical protein 0.0038 0.0286 0.0557
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0 0.5
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0489 0.0952
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.015 0.1842 0.1842
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.1942 0.4045
Echinococcus multilocularis Smad4 0.0025 0.0093 0.0093
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0699 0.1407
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.2304 0.2304
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0617 0.1242
Brugia malayi mbt repeat family protein 0.0046 0.0399 0.0777
Mycobacterium tuberculosis Conserved hypothetical protein 0.0175 0.2189 0.4127
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0093 0.0093
Entamoeba histolytica cysteine protease, putative 0.0018 0 0.5
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0399 0.0399
Onchocerca volvulus 0.0046 0.0399 0.1862
Echinococcus multilocularis musashi 0.0052 0.0481 0.0481
Loa Loa (eye worm) hypothetical protein 0.0172 0.2143 0.4174
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0521 0.0521
Echinococcus granulosus lamin 0.0052 0.0481 0.0481
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0286 1
Mycobacterium ulcerans hypothetical protein 0.0175 0.2189 0.3925
Loa Loa (eye worm) Smad1 0.0025 0.0093 0.0181
Schistosoma mansoni FFA transport protein 0.0374 0.4965 0.4965
Schistosoma mansoni intermediate filament proteins 0.0052 0.0481 0.0481
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0521 0.0521
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0699 0.1407
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0 0.5
Echinococcus granulosus tumor protein p63 0.036 0.477 0.477
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0286 1
Brugia malayi Smad1 0.0025 0.0093 0.0181
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.1267 0.2468
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0521 0.0521
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0286 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0402 0.0284
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0175
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0699 0.1008
Brugia malayi Intermediate filament tail domain containing protein 0.0052 0.0481 0.0936
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0175
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0231 0.045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0699 0.1008
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0489 0.0489
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0787 0.1534
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0521 0.0521
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0231 0.045
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0386 0.5134 1
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0374 0.4965 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0286 0.0557
Echinococcus multilocularis lamin dm0 0.0052 0.0481 0.0481
Schistosoma mansoni smad1 5 8 and 0.0025 0.0093 0.0093
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0374 0.4965 1
Echinococcus multilocularis lamin 0.0052 0.0481 0.0481
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0231 0.0231
Brugia malayi MH2 domain containing protein 0.0025 0.0093 0.0181
Onchocerca volvulus 0.0038 0.0286 0.1335
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0699 0.1008
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0286 1
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0699 0.1407
Echinococcus multilocularis thyroid hormone receptor alpha 0.0162 0.201 0.201
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0332 0.438 0.882
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0399 0.0399
Echinococcus granulosus long chain fatty acid transport protein 4 0.0374 0.4965 0.4965
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0093 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0699 0.1008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0286 0.0557
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0286 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0286 1
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0374 0.4965 0.4965
Loa Loa (eye worm) hypothetical protein 0.0038 0.0286 0.0557
Schistosoma mansoni thyroid hormone receptor 0.0162 0.201 0.201
Schistosoma mansoni thyroid hormone receptor 0.0162 0.201 0.201
Schistosoma mansoni lamin 0.0052 0.0481 0.0481
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0699 0.1008
Onchocerca volvulus 0.0053 0.0486 0.2267
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0489 0.0489
Onchocerca volvulus 0.0052 0.0481 0.2242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0699 0.1008
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0142 0.0277
Loa Loa (eye worm) hypothetical protein 0.0074 0.0787 0.1534
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.015 0.1842 0.1842
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0402 0.081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0699 0.1008
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0231 0.045
Loa Loa (eye worm) MBCTL1 0.0053 0.0489 0.0952
Leishmania major fatty acid transporter protein-like protein 0.0369 0.4897 1
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0399 0.0399
Brugia malayi follicle stimulating hormone receptor 0.028 0.3648 0.7106
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0286 0.0286
Loa Loa (eye worm) beta-lactamase 0.0038 0.0286 0.0557
Brugia malayi MH2 domain containing protein 0.036 0.4767 0.9284
Onchocerca volvulus 0.0038 0.0286 0.1335
Schistosoma mansoni hypothetical protein 0.0283 0.3688 0.3688
Brugia malayi beta-lactamase family protein 0.0038 0.0286 0.0557
Leishmania major cathepsin L-like protease 0.0068 0.0699 0.1427
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0025 0.0103 0.0103
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0544 0.1097
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0025 0.0103 0.0103
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0402 0.081
Toxoplasma gondii hypothetical protein 0.0054 0.0498 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0038 0.0286 0.0557
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0051 0.0467 0.091
Loa Loa (eye worm) hypothetical protein 0.0038 0.0286 0.0557
Brugia malayi beta-lactamase family protein 0.0038 0.0286 0.0557
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0369 0.4897 1
Schistosoma mansoni hypothetical protein 0.0034 0.0231 0.0231
Brugia malayi mbt repeat family protein 0.0046 0.0399 0.0777
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0286 0.0576
Brugia malayi MH1 domain containing protein 0.0025 0.0093 0.0181
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0142 0.0277
Schistosoma mansoni hypothetical protein 0.0074 0.0787 0.0787
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0332 0.438 0.882
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0496 0.0999
Loa Loa (eye worm) hypothetical protein 0.0025 0.0103 0.0201
Brugia malayi MH1 domain containing protein 0.0025 0.0093 0.0181
Schistosoma mansoni hypothetical protein 0.0034 0.0231 0.0231
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0489 0.0489
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0369 0.4897 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0093 0.0093

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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