Detailed information for compound 732158

Basic information

Technical information
  • TDR Targets ID: 732158
  • Name: (3aS,5S,9aS)-2-(2-methoxybenzyl)-5-(2-methylp henyl)hexahydro-7H-pyrrolo[3,4-g]pyrrolizin-1 (2H)-one
  • MW: 376.491 | Formula: C24H28N2O2
  • H donors: 0 H acceptors: 1 LogP: 3.66 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1CN1C[C@H]2[C@]3(C1=O)CCCN3[C@@H](C2)c1ccccc1C
  • InChi: 1S/C24H28N2O2/c1-17-8-3-5-10-20(17)21-14-19-16-25(15-18-9-4-6-11-22(18)28-2)23(27)24(19)12-7-13-26(21)24/h3-6,8-11,19,21H,7,12-16H2,1-2H3/t19-,21-,24-/m0/s1
  • InChiKey: YENMJTKTOUELBQ-PTLVVNQVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • MLS000773192
  • SMR000317056

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pre-SET motif family protein 0.0231 0.162 0.7154
Loa Loa (eye worm) hypothetical protein 0.0097 0.0611 0.2696
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0111 0.0714 1
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0196 0.4548
Echinococcus multilocularis microtubule associated protein 2 0.0764 0.5649 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.013 0.023
Trypanosoma brucei THT1 - hexose transporter, putative 0.0098 0.062 0.8675
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0062 0.0347 0.1477
Brugia malayi hypothetical protein 0.0076 0.0455 0.201
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0953
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Leishmania major glucose transporter, lmgt2 0.0098 0.062 0.8651
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0015 0.0039
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0065
Brugia malayi hypothetical protein 0.0044 0.0216 0.0953
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0015 0.00000075735
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0196 0.0346
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0953
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0056 0.0596
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0196 0.4548
Giardia lamblia Lysyl-tRNA synthetase 0.0071 0.0413 0.6849
Trypanosoma cruzi sugar transporter, putative 0.0044 0.0216 0.2874
Onchocerca volvulus 0.0042 0.0196 0.0753
Schistosoma mansoni hypothetical protein 0.0316 0.2265 0.4009
Echinococcus granulosus solute carrier family 22 0.0044 0.0216 0.0382
Entamoeba histolytica hypothetical protein 0.0076 0.0455 0.7393
Trichomonas vaginalis set domain proteins, putative 0.0262 0.1861 0.8203
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0018 0.0015 0.0065
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0267 0.1894 1
Trypanosoma brucei glucose transporter, putative 0.0098 0.062 0.8675
Loa Loa (eye worm) hypothetical protein 0.0042 0.0196 0.0864
Brugia malayi beta-lactamase family protein 0.0042 0.0196 0.0864
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0056 0.01
Loa Loa (eye worm) hypothetical protein 0.0077 0.0462 0.2039
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0095 0.0596 0.9752
Loa Loa (eye worm) major facilitator superfamily transporter 0.0044 0.0216 0.0953
Echinococcus multilocularis General substrate transporter 0.0272 0.193 0.3416
Trypanosoma cruzi hexose transporter, putative 0.0044 0.0216 0.2874
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0196 0.2587
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0097 0.0611 0.0597
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.013 0.023
Schistosoma mansoni tar DNA-binding protein 0.0064 0.036 0.0638
Brugia malayi RNA binding protein 0.0064 0.036 0.1591
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Loa Loa (eye worm) hypothetical protein 0.0034 0.0139 0.0612
Echinococcus granulosus dna polymerase kappa 0.0023 0.0056 0.01
Echinococcus granulosus solute carrier family 22 0.0044 0.0216 0.0382
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.013 0.0175
Onchocerca volvulus 0.0044 0.0216 0.0865
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.0265
Schistosoma mansoni lysyl-tRNA synthetase 0.0071 0.0413 0.0731
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0196 0.0998
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0196 0.0805
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0316 0.2265 0.4009
Trypanosoma brucei sugar transporter, putative 0.0044 0.0216 0.3003
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0196 0.0805
Schistosoma mansoni sugar transporter 0.0044 0.0216 0.0382
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0095 0.0596 0.1055
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.0265
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0056 0.026
Schistosoma mansoni hypothetical protein 0.0076 0.0455 0.0806
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0056 0.0766
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0071 0.0413 0.5689
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0297 0.0526
Echinococcus granulosus tumor protein p63 0.0339 0.2439 0.4318
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Schistosoma mansoni tar DNA-binding protein 0.0064 0.036 0.0638
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0071 0.0413 0.6849
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0316 0.2265 0.4009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0297 0.0526
Onchocerca volvulus 0.0044 0.0216 0.0865
Echinococcus granulosus Sugar transporter ERD6 protein 0.0044 0.0216 0.0382
Trichomonas vaginalis glucose transporter, putative 0.0098 0.062 0.269
Echinococcus granulosus survival motor neuron protein 1 0.0272 0.1934 0.3424
Schistosoma mansoni microtubule-associated protein tau 0.0764 0.5649 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0611 0.1081
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0018 0.0015 0.0065
Loa Loa (eye worm) hypothetical protein 0.0042 0.0196 0.0864
Plasmodium falciparum protein kinase 7 0.0893 0.6617 0.6612
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0196 0.0864
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0611 0.1081
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0044 0.0216 0.1105
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0056 0.07
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0071 0.0413 1
Schistosoma mansoni glycyl-tRNA synthetase 0.0018 0.0015 0.0026
Loa Loa (eye worm) hypothetical protein 0.005 0.0255 0.1126
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0056 0.0596
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0056 0.1048
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0231 0.162 0.7154
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0015 0.00000075735
Trypanosoma brucei glucose transporter, putative 0.0098 0.062 0.8675
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0196 0.0998
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.013 0.023
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.006 0.0333 0.1723
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0953
Loa Loa (eye worm) hypothetical protein 0.0042 0.0196 0.0864
Toxoplasma gondii sugar transporter ST1 0.0044 0.0216 0.0305
Leishmania major protein kinase, putative 0.0097 0.0611 0.8517
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0097 0.0611 0.8544
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0097 0.0611 0.0597
Schistosoma mansoni hypothetical protein 0.0056 0.0299 0.053
Schistosoma mansoni sugar transporter 0.0044 0.0216 0.0382
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.006 0.114
Trichomonas vaginalis glucose transporter, putative 0.0044 0.0216 0.0894
Schistosoma mansoni protein kinase 0.0097 0.0611 0.1081
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0766
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0056 0.0766
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0056 0.0596
Trichomonas vaginalis conserved hypothetical protein 0.0316 0.2265 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0455 0.0806
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0297 0.0526
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.0611 0.1081
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0056 0.1048
Echinococcus granulosus tar DNA binding protein 0.0064 0.036 0.0638
Onchocerca volvulus 0.0044 0.0216 0.0865
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0953
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0316 0.2265 0.4009
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Brugia malayi major facilitator superfamily protein 0.0044 0.0216 0.0953
Onchocerca volvulus 0.0042 0.0196 0.0753
Schistosoma mansoni protein kinase 0.0097 0.0611 0.1081
Onchocerca volvulus 0.005 0.0255 0.1083
Schistosoma mansoni sugar transporter 0.0044 0.0216 0.0382
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0095 0.0596 1
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Brugia malayi beta-lactamase family protein 0.0042 0.0196 0.0864
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Schistosoma mansoni lysyl-tRNA synthetase 0.0071 0.0413 0.0731
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.006 0.114
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0766
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0056 0.01
Loa Loa (eye worm) hypothetical protein 0.0042 0.0196 0.0864
Loa Loa (eye worm) beta-lactamase 0.0042 0.0196 0.0864
Plasmodium vivax proline--tRNA ligase, putative 0.0111 0.0714 0.0701
Echinococcus multilocularis tar DNA binding protein 0.0064 0.036 0.0638
Echinococcus granulosus solute carrier family 22 0.0044 0.0216 0.0382
Plasmodium falciparum proline--tRNA ligase 0.0111 0.0714 0.0701
Schistosoma mansoni hypothetical protein 0.0034 0.0139 0.0245
Plasmodium falciparum lysine--tRNA ligase 0.0071 0.0413 0.0399
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0258 0.1139
Trypanosoma brucei glucose transporter, putative 0.0098 0.062 0.8675
Giardia lamblia Sugar-proton symporter 0.0044 0.0216 0.346
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0255 0.0452
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0056 0.0185
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0056 0.0249
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0095 0.0596 0.1055
Leishmania major glucose transporter/membrane transporter D2, putative 0.0098 0.062 0.8651
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.006 0.114
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0018 0.0015 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0216 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.006 0.0333 0.1723
Treponema pallidum prolyl-tRNA synthetase 0.0033 0.0133 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0044 0.0216 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0097 0.0611 0.2696
Plasmodium falciparum calcium-dependent protein kinase 3 0.0097 0.0611 0.0597
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0018 0.0015 0.018
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0953
Onchocerca volvulus 0.0033 0.013 0.0389
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0316 0.2265 0.4009
Trypanosoma brucei glucose transporter, putative 0.0098 0.062 0.8675
Brugia malayi Sugar transporter family protein 0.0044 0.0216 0.0953
Trichomonas vaginalis myo-inositol transporter, putative 0.0044 0.0216 0.0894
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.006 0.114
Onchocerca volvulus 0.0044 0.0216 0.0865
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0316 0.2265 0.4009
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0316 0.2265 0.4009
Onchocerca volvulus 0.0044 0.0216 0.0865
Mycobacterium ulcerans hypothetical protein 0.0024 0.006 0.114
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.006 0.0333 0.5469
Plasmodium vivax CDK-related protein kinase 6, putative 0.1341 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.013 0.023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0065
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0766
Plasmodium vivax calcium-dependent protein kinase, putative 0.0097 0.0611 0.0597
Echinococcus multilocularis calcium dependent protein kinase 0.0091 0.0565 0.1001
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0065
Brugia malayi beta-lactamase 0.0042 0.0196 0.0864
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0039 0.0174 0.0769
Echinococcus multilocularis tumor protein p63 0.0339 0.2439 0.4318
Loa Loa (eye worm) sugar transporter 0.0044 0.0216 0.0953
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0196 0.0864
Onchocerca volvulus 0.0044 0.0216 0.0865
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0766
Mycobacterium ulcerans sugar transporter 0.0044 0.0216 0.5052
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0953
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0766
Onchocerca volvulus 0.0042 0.0196 0.0753
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Echinococcus granulosus microtubule associated protein 2 0.0764 0.5649 1
Brugia malayi glycyl-tRNA synthetase 0.0018 0.0015 0.0065
Echinococcus multilocularis lysyl tRNA synthetase 0.0071 0.0413 0.0731
Giardia lamblia DINP protein human, muc B family 0.0023 0.0056 0.0718
Onchocerca volvulus 0.0044 0.0216 0.0865
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.006 0.0279
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0196 0.0805
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0196 0.0998
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0196 0.0181
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.036 0.1591
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.036 0.1591
Loa Loa (eye worm) major facilitator superfamily transporter 0.0044 0.0216 0.0953
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0056 0.0766
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0044 0.0216 0.0382
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0297 0.0526
Schistosoma mansoni glucose transport protein 0.0316 0.2265 0.4009
Toxoplasma gondii sugar transporter ST3 0.0044 0.0216 0.0305
Onchocerca volvulus 0.0044 0.0216 0.0865
Loa Loa (eye worm) RNA binding protein 0.0064 0.036 0.1591
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0216 0.0894
Toxoplasma gondii transporter, major facilitator family protein 0.0044 0.0216 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.062 0.269
Brugia malayi Sugar transporter family protein 0.0044 0.0216 0.0953
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0097 0.0611 0.2696
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0097 0.0611 0.0903
Mycobacterium ulcerans hypothetical protein 0.0042 0.0196 0.4548
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.013 0.023
Trypanosoma brucei glucose transporter 1E 0.0098 0.062 0.8675
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0044 0.0216 0.5052
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.006 0.0762
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0111 0.0714 1
Brugia malayi TAR-binding protein 0.0064 0.036 0.1591
Loa Loa (eye worm) hypothetical protein 0.0095 0.0596 0.2631
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0216 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0316 0.2265 0.4009
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Leishmania major hypothetical protein, conserved 0.0044 0.0216 0.2874
Trypanosoma cruzi glucose transporter, putative 0.0044 0.0216 0.2874
Plasmodium vivax hexose transporter 0.0316 0.2265 0.2253
Brugia malayi Pre-SET motif family protein 0.0033 0.013 0.0574
Onchocerca volvulus Putative transporter 0.0044 0.0216 0.0865
Mycobacterium tuberculosis Conserved protein 0.0042 0.0196 0.0998
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0139 0.0612
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0297 0.1313
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0056 0.026
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0953
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0097 0.0611 0.1081
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0095 0.0596 0.2583
Brugia malayi Major Facilitator Superfamily protein 0.0044 0.0216 0.0953
Brugia malayi AMP-binding enzyme family protein 0.0024 0.006 0.0265
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0044 0.0216 0.0201
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0299 0.1322
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0953
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0511 0.3733 0.3724
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0111 0.0714 0.106
Toxoplasma gondii ABC1 family protein 0.0042 0.0196 0.0274
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0097 0.0611 0.1081
Mycobacterium leprae Probable lipase LipE 0.0042 0.0196 0.3115
Plasmodium falciparum calcium-dependent protein kinase 5 0.0097 0.0611 0.0597
Plasmodium falciparum calcium-dependent protein kinase 1 0.0097 0.0611 0.0597
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0033 0.0133 0.2978
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0611 0.1081
Echinococcus granulosus dna polymerase eta 0.0023 0.0056 0.01
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0056 0.0249
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0095 0.0596 0.2631
Entamoeba histolytica protein kinase, putative 0.0097 0.0611 1
Leishmania major glucose transporter, lmgt1 0.0098 0.062 0.8651
Trypanosoma brucei THT1 - hexose transporter, putative 0.0098 0.062 0.8675
Loa Loa (eye worm) hypothetical protein 0.0272 0.1934 0.8541
Echinococcus granulosus lysyl tRNA synthetase 0.0071 0.0413 0.0731
Trichomonas vaginalis esterase, putative 0.0042 0.0196 0.0805
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0766
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0044 0.0216 0.5052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0297 0.0526
Brugia malayi Major Facilitator Superfamily protein 0.0044 0.0216 0.0953
Loa Loa (eye worm) hypothetical protein 0.0042 0.0196 0.0864
Echinococcus multilocularis survival motor neuron protein 1 0.0272 0.1934 0.3424
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Schistosoma mansoni protein kinase 0.0097 0.0611 0.1081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.013 0.023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.006 0.0279
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0097 0.0611 0.0597
Mycobacterium tuberculosis Conserved protein 0.0042 0.0196 0.0998
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0196 0.0346
Trypanosoma brucei glucose transporter, putative 0.0098 0.062 0.8675
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0196 0.0805
Plasmodium falciparum hexose transporter 0.0316 0.2265 0.2253
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.006 0.114
Mycobacterium tuberculosis Conserved protein 0.0042 0.0196 0.0998
Trypanosoma brucei glucose transporter 2A 0.0098 0.062 0.8675
Schistosoma mansoni glucose transport protein 0.0316 0.2265 0.4009
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0097 0.0611 0.0903
Echinococcus multilocularis glycyl tRNA synthetase 0.0018 0.0015 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.006 0.0649
Echinococcus multilocularis solute carrier family 22 0.0044 0.0216 0.0382
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0056 0.0766
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0071 0.0413 0.5767
Echinococcus granulosus General substrate transporter 0.0272 0.193 0.3416
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0196 0.2587
Trichomonas vaginalis sugar transport protein, putative 0.0044 0.0216 0.0894
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0953
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0044 0.0216 0.3003
Brugia malayi hypothetical protein 0.0044 0.0216 0.0953
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0297 0.1313
Trypanosoma brucei unspecified product 0.0023 0.0056 0.0766
Schistosoma mansoni hypothetical protein 0.0164 0.1116 0.1975
Trypanosoma cruzi hexose transporter, putative 0.0098 0.062 0.8651
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0216 0.0894
Loa Loa (eye worm) sugar transporter 0.0316 0.2265 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0511 0.3733 0.3724
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0065
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0953
Onchocerca volvulus 0.0262 0.1861 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0258 0.1139
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0196 0.0998
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0953
Mycobacterium ulcerans lipase LipD 0.0042 0.0196 0.4548
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0511 0.3733 0.5632
Toxoplasma gondii protein kinase, putative 0.0893 0.6617 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0766
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0111 0.0714 1
Leishmania major glucose transporter, lmgt3 0.0098 0.062 0.8651
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0056 0.0596
Leishmania major DNA polymerase eta, putative 0.0023 0.0056 0.0596
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0196 0.0346
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0111 0.0714 1
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0196 0.0998
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0056 0.0249
Mycobacterium ulcerans beta-lactamase 0.0042 0.0196 0.4548
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.006 0.114
Trypanosoma brucei THT1 - hexose transporter, putative 0.0098 0.062 0.8675
Trichomonas vaginalis sugar transporter, putative 0.0098 0.062 0.269
Brugia malayi Sugar transporter family protein 0.0316 0.2265 1
Leishmania major lysyl-tRNA synthetase, putative 0.0071 0.0413 0.5689
Onchocerca volvulus 0.0044 0.0216 0.0865
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0095 0.0596 0.1055
Brugia malayi major facilitator superfamily protein 0.0044 0.0216 0.0953
Trichomonas vaginalis sugar transporter, putative 0.0098 0.062 0.269
Chlamydia trachomatis lysine--tRNA ligase 0.0071 0.0413 1
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.006 0.0762
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.006 0.0781
Entamoeba histolytica hypothetical protein 0.0076 0.0455 0.7393
Trichomonas vaginalis sugar transporter, putative 0.0098 0.062 0.269
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0258 0.1139
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Schistosoma mansoni glucose transport protein 0.0316 0.2265 0.4009
Schistosoma mansoni DNA polymerase eta 0.0023 0.0056 0.01
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0018 0.0015 0.0065
Brugia malayi lysyl-tRNA synthetase 0.0071 0.0413 0.1822
Chlamydia trachomatis proline--tRNA ligase 0.0033 0.0133 0.2978
Echinococcus multilocularis solute carrier family 22 0.0044 0.0216 0.0382
Brugia malayi AMP-binding enzyme family protein 0.0024 0.006 0.0265
Entamoeba histolytica hypothetical protein 0.0071 0.0413 0.6679
Trypanosoma brucei glucose transporter, putative 0.0098 0.062 0.8675
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.013 0.023
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0097 0.0611 0.1081
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0056 0.01
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.006 0.0649
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.0611 0.2648
Loa Loa (eye worm) hypothetical protein 0.0071 0.0413 0.1822
Plasmodium vivax sugar transporter, putative 0.0044 0.0216 0.0201
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0097 0.0611 0.1081
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0056 0.0596
Loa Loa (eye worm) hypothetical protein 0.0033 0.013 0.0574
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0297 0.0526
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0097 0.0611 0.1081
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.0265
Leishmania major hypothetical protein, conserved 0.0042 0.0196 0.2587
Entamoeba histolytica hypothetical protein 0.0076 0.0455 0.7393
Loa Loa (eye worm) hypothetical protein 0.0095 0.0596 0.2631
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0766
Brugia malayi AMP-binding enzyme family protein 0.0024 0.006 0.0265
Loa Loa (eye worm) hypothetical protein 0.0042 0.0196 0.0864
Leishmania major DNA polymerase kappa, putative 0.0023 0.0056 0.0596
Echinococcus multilocularis solute carrier family 22 0.0044 0.0216 0.0382
Plasmodium falciparum calcium-dependent protein kinase 4 0.0097 0.0611 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Schistosoma mansoni glucose transporter 0.0044 0.0216 0.0382
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0455 0.0806
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0056 0.0596
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Onchocerca volvulus 0.0044 0.0216 0.0865
Loa Loa (eye worm) TAR-binding protein 0.0064 0.036 0.1591
Schistosoma mansoni hypothetical protein 0.0164 0.1116 0.1975
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0953
Trypanosoma cruzi hexose transporter, putative 0.0098 0.062 0.8651
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.006 0.0762
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0196 0.0998
Leishmania major myo-inositol/proton symporter (MIT) 0.0044 0.0216 0.2874
Plasmodium vivax lysine--tRNA ligase, putative 0.0071 0.0413 0.0399
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.006 0.0781
Entamoeba histolytica protein kinase, putative 0.0097 0.0611 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0766
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0953
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Plasmodium vivax SET domain protein, putative 0.0033 0.013 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Echinococcus multilocularis dna polymerase eta 0.0023 0.0056 0.01
Trypanosoma cruzi hexose transporter, putative 0.0054 0.0285 0.386
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0056 0.01
Onchocerca volvulus 0.0044 0.0216 0.0865
Toxoplasma gondii lysine-tRNA ligase 0.0071 0.0413 0.0603
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0065
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0071 0.0413 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0216 0.0894
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0097 0.0611 0.0903
Schistosoma mansoni sugar transporter 0.0044 0.0216 0.0382
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.006 0.114
Echinococcus granulosus solute carrier family 22 0.0044 0.0216 0.0382
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Schistosoma mansoni tar DNA-binding protein 0.0064 0.036 0.0638
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0097 0.0611 0.2696
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0018 0.0015 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0098 0.062 0.269
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0316 0.2265 0.4009
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0018 0.0015 0.0039
Mycobacterium ulcerans integral membrane transport protein 0.0044 0.0216 0.5052
Brugia malayi hypothetical protein 0.0044 0.0216 0.0953
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0121 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0056 0.0766
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0196 0.0998
Echinococcus multilocularis synaptic vesicle 2 protein 0.0044 0.0216 0.0382
Giardia lamblia Prolyl-tRNA synthetase 0.0095 0.0596 1
Echinococcus multilocularis geminin 0.0164 0.1116 0.1975
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Loa Loa (eye worm) hypothetical protein 0.005 0.0258 0.1139
Trypanosoma brucei glucose transporter, putative 0.0098 0.062 0.8675
Trichomonas vaginalis glucose transporter, putative 0.0098 0.062 0.269
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0095 0.0596 0.1055
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0953
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0196 0.2721
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0095 0.0596 0.2631
Echinococcus granulosus synaptic vesicle 2 protein 0.0044 0.0216 0.0382
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0196 0.0805
Toxoplasma gondii sugar transporter ST2 0.0044 0.0216 0.0305
Loa Loa (eye worm) hypothetical protein 0.0023 0.0056 0.0249
Echinococcus granulosus calcium dependent protein kinase 0.0091 0.0565 0.1001
Onchocerca volvulus 0.0044 0.0216 0.0865
Brugia malayi hypothetical protein 0.0272 0.1934 0.8541
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Echinococcus granulosus Threonyl tRNA synthetase C 0.0018 0.0015 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.006 0.0649
Loa Loa (eye worm) hypothetical protein 0.0044 0.0216 0.0953
Brugia malayi Major Facilitator Superfamily protein 0.0044 0.0216 0.0953
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Giardia lamblia Hexose transporter 0.0044 0.0216 0.346
Onchocerca volvulus 0.0056 0.0299 0.133
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0044 0.0216 0.1105
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0056 0.01
Trypanosoma brucei glucose transporter, putative 0.0098 0.062 0.8675
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0044 0.0216 0.0382
Trypanosoma cruzi hexose transporter 0.0098 0.062 0.8651
Onchocerca volvulus 0.0044 0.0216 0.0865
Echinococcus multilocularis solute carrier family 22 0.0044 0.0216 0.0382
Entamoeba histolytica hypothetical protein 0.0076 0.0455 0.7393
Onchocerca volvulus 0.0044 0.0216 0.0865
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0065
Schistosoma mansoni survival motor neuron protein 0.0056 0.0299 0.053
Echinococcus granulosus glycyl tRNA synthetase 0.0018 0.0015 0.0026
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0018 0.0015 0.0065
Schistosoma mansoni tar DNA-binding protein 0.0064 0.036 0.0638
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0196 0.0346
Schistosoma mansoni tar DNA-binding protein 0.0064 0.036 0.0638
Onchocerca volvulus 0.0044 0.0216 0.0865
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0071 0.0413 0.1769
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0455 0.0806
Brugia malayi Cam kinase protein 1 0.0097 0.0611 0.2696
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0056 0.0185
Onchocerca volvulus 0.0044 0.0216 0.0865
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0297 0.0526
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0111 0.0714 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0097 0.0611 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0216 0.0894
Trypanosoma cruzi hexose transporter, putative 0.0098 0.062 0.8651
Echinococcus granulosus geminin 0.0164 0.1116 0.1975
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0196 0.3115
Toxoplasma gondii facilitative glucose transporter GT1 0.0316 0.2265 0.3408

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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